Physiology & Behavior最新文献_第6页

Comparing the effects of a brief walk in nature versus indoors on affect and cognitive function 比较在大自然中和在室内短暂散步对情绪和认知功能的影响。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-20 DOI: 10.1016/j.physbeh.2025.115209

Karly Knudson , C.J. Brush

Research has shown that a single bout of physical activity is associated with cognitive-affective benefits. However, most research has been conducted in controlled laboratory settings. Less is known whether these effects are similar across different environments. The purpose of the study was to compare the effects of a 15 min walk performed in nature versus indoors on affect and cognitive function. Twenty-eight participants (n = 16 female; aged 18–32) completed a 15 min nature walk and 15 min indoor walk in a randomized counterbalanced order on separate days as part of a within-subjects crossover design. Affect, assessed within the circumplex model (affective valence: pleasure—displeasure; perceived activation: high—low arousal), was measured before, during, and immediately after each walk. Following each walk, participants completed a three-stimulus go/no-go task with concurrent electroencephalographic recording to assess cognitive function. Ratings of perceived exertion were collected to determine the intensity of each walk. Results indicated that participants reported increased pleasure and perceived activation during and immediately following the nature compared to indoor walk. Behavioral performance (reaction time and accuracy) on the go/no-go task did not differ between conditions; however, P3 amplitude of the event-related potential (ERP) was significantly larger following the nature walk. Both walks were consistent with a very light intensity. These findings indicate that engaging in a brief walk in nature may result in added cognitive-affective benefits compared to walking indoors. Incorporation of natural settings may be an effective strategy to enhance the affective experience and cognitive aftereffects of a single bout of physical activity.

研究表明，一次体育活动与认知情感益处有关。然而，大多数研究都是在受控的实验室环境中进行的。目前尚不清楚这些影响在不同环境中是否相似。这项研究的目的是比较在自然中和在室内散步15分钟对情绪和认知功能的影响。28名参与者（n=16名女性，年龄在18-32岁）在不同的日子以随机平衡的顺序完成了15分钟的自然散步和15分钟的室内散步，作为受试者交叉设计的一部分。在每次行走前、行走中和行走后，用环复模型评估（情感效价：愉悦-不悦；感知激活：高-低唤醒）。每次散步后，参与者完成一项有三种刺激的“走/不走”任务，同时进行脑电图记录，以评估认知功能。收集感知运动的评分，以确定每次步行的强度。结果表明，与室内散步相比，参与者报告说，在大自然中以及在大自然之后，他们的愉悦感和感知活动都有所增加。在不同条件下，行动/不行动任务的行为表现（反应时间和准确性）没有差异；然而，事件相关电位（ERP）的P3振幅在自然散步后明显增大。两次散步的强度都很轻。这些发现表明，与在室内散步相比，在大自然中短暂散步可能会带来额外的认知情感益处。结合自然环境可能是一种有效的策略，可以增强一次体育活动的情感体验和认知后遗症。

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引用次数: 0

Genetic background and reversal learning: differences in behavioral flexibility between CD1 and C57BL/6 strains in the mid-session reversal task 遗传背景与逆向学习：CD1和C57BL/6菌株在会话中期逆向任务中的行为灵活性差异

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-17 DOI: 10.1016/j.physbeh.2025.115208

Ana Patricia Orozco-Coles , Tania Campos-Ordoñez , Jonathan Buriticá

Reversal learning is the ability to modify responses based on changes in stimulus-outcome contingencies. Behavioral flexibility is crucial for adaptive behavior in dynamic environments, where organisms must suppress previously acquired responses and adopt new strategies to survive. In this study, we compared two mouse strains: C57BL/6 (inbred) mice, which offer genetic uniformity, and CD1 (outbred) mice, providing genetic diversity. Mice were tested in the mid-session reversal (MSR) task under three conditions: fixed reversal with 100% reinforcement (F100), variable reversal with 100% reinforcement (V100), and variable reversal with 50% reinforcement (V50). To account for prior experience, phases 1 and 2 were counterbalanced across subjects. Both strains completed the MSR task but showed distinct response profiles. CD1 mice showed consistent adaptation across reversal conditions (F100 and V100), maintaining high accuracy. Under reduced reinforcement predictability (V50), both strains showed increased variability, indicating diminished stimulus control. Individuals from both strains employ a mix of win-stay/lose-shift (WSLS) and temporal strategies; however, these do not always yield optimal results, indicating that their responses are driven by a blend of tactics rather than fixed rules. Notably, the order of conditions had a greater effect on C57BL/6 mice, suggesting increased sensitivity to task order. These findings highlight the influence of genetic background and reinforcement structure on reversal learning. Strain-specific profiles should be considered when selecting models for research on cognitive flexibility, reinforcement sensitivity, and translational studies related to decision-making under uncertainty.

逆向学习是一种根据刺激-结果偶然性的变化来调整反应的能力。行为灵活性对于动态环境中的适应性行为至关重要，生物体必须抑制先前获得的反应并采用新的策略来生存。在这项研究中，我们比较了两种小鼠品系：提供遗传一致性的C57BL/6（近交系）小鼠和提供遗传多样性的CD1（远交系）小鼠。小鼠在三种条件下进行中期逆转（MSR）任务：100%强化的固定逆转（F100）、100%强化的可变逆转（V100）和50%强化的可变逆转（V50）。考虑到先前的经验，阶段1和阶段2在受试者之间是平衡的。两株菌株均完成了MSR任务，但表现出不同的反应谱。CD1小鼠在逆转条件（F100和V100）中表现出一致的适应性，保持了较高的准确性。在较低的强化可预测性（V50）下，两种菌株都表现出增加的变异性，表明刺激控制减弱。来自这两个菌株的个体采用了赢-留/输-换（WSLS）和时间策略的混合；然而，这些并不总是产生最佳结果，这表明他们的反应是由混合战术而不是固定规则驱动的。值得注意的是，条件顺序对C57BL/6小鼠有更大的影响，表明对任务顺序的敏感性增加。这些发现突出了遗传背景和强化结构对反转学习的影响。在选择模型进行认知灵活性、强化敏感性和不确定性下决策相关的转译研究时，应考虑应变特异性特征。

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引用次数: 0

Gastrointestinal dysmotility and impaired gut peptide-satiety coupling in men with spinal cord injury 脊髓损伤男性的胃肠运动障碍和肠肽-饱腹性偶联受损。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-15 DOI: 10.1016/j.physbeh.2025.115207

Gary J. Farkas , Paige M. Cunningham , Arthur S. Berg , George Jimsheleishvili , Armando J. Mendez , David R. Gater Jr. , Mark S. Nash , Barbara J. Rolls

Overeating associated with neurogenic obesity in chronic spinal cord injury (SCI) may reflect disruptions in gastrointestinal transit, satiety hormone responses, and appetite regulation. In this pilot study, 16 men with SCI (50 % tetraplegia) and 16 controls without SCI consumed standardized meals (195 g and 390 g) during 2 different laboratory visits. Gastrointestinal (GI) motility was measured using the SmartPill Wireless Motility Capsule during the first visit, while postprandial levels of GI peptides, glucose, insulin, and triglycerides were assessed during the second. Ratings of hunger and satiety were collected pre- and post-prandially in both visits. SCI participants exhibited GI dysmotility and exaggerated glycemic and lipemic excursions (all, p < 0.05) consistent with delayed GI transit. Associations between GI peptides and ratings of hunger and satiety were weaker in SCI, including attenuated ghrelin-hunger and GLP-1-fullness coupling (p < 0.05). Instead, fullness was more strongly associated with glucose in SCI (p < 0.05), indicating a potential shift toward glycemic cues in appetite regulation. The association between insulin and GLP-1 was stronger in SCI, consistent with a possible compensatory incretin signaling in response to impaired metabolic regulation. Together, these findings suggest disrupted gut-brain and metabolic signaling in SCI may impair appetite regulation, highlighting the need to further investigate gut-brain communication in relation to food intake.

慢性脊髓损伤（SCI）患者与神经源性肥胖相关的暴饮暴食可能反映了胃肠道转运、饱腹激素反应和食欲调节的中断。在这项初步研究中，16名患有脊髓损伤（50%四肢瘫痪）的男性和16名没有脊髓损伤的对照组在两次不同的实验室访问中食用标准化膳食（195 g和390 g）。在第一次访问期间使用SmartPill无线运动胶囊测量胃肠道（GI）运动，而在第二次访问期间评估餐后胃肠道肽，葡萄糖，胰岛素和甘油三酯水平。在两次访问中，饥饿感和饱腹感都是在餐后收集的。SCI参与者表现出GI运动障碍和夸大的血糖和血脂漂移（均p < 0.05），与GI转运延迟一致。在脊髓损伤中，GI肽与饥饿感和饱腹感之间的关联较弱，包括ghrelin-hunger和glp -1-饱腹感耦合减弱（p < 0.05）。相反，在脊髓损伤中，饱腹感与葡萄糖的相关性更强（p < 0.05），这表明食欲调节可能向血糖信号转变。在脊髓损伤中，胰岛素和GLP-1之间的关联更强，这可能与代偿性肠促胰岛素信号传导对代谢调节受损的反应相一致。总之，这些发现表明，脊髓损伤中肠-脑和代谢信号的中断可能会损害食欲调节，强调需要进一步研究肠-脑通信与食物摄入的关系。

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引用次数: 0

The effect of circadian rhythm and cortisol levels on health nutrition attitudes, emotional eating, and anthropometric measurements in university students 生理节律和皮质醇水平对大学生健康营养态度、情绪饮食和人体测量的影响。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-15 DOI: 10.1016/j.physbeh.2025.115205

Gamze Demirel , Zeynep BAL Ayyildiz , Zeynep Burcu Kahraman , Selma İnfal Kesim

Circadian rhythm, eating attitudes, and stress responses are important determinants of well-being among university students. This study hypothesized that circadian rhythm characteristics would be associated with emotional eating, healthy nutrition attitudes, and salivary cortisol levels. Therefore, this cross-sectional study investigated the associations between chronotype, sleep patterns, eating behaviors, and cortisol concentrations among 213 university students (131 nursing; 82 nutrition and dietetics). Data were collected using the Morningness-Eveningness Questionnaire, the Emotional Eater Questionnaire (EEQ-TR), and the Attitude Scale for Healthy Nutrition (ASHN). Anthropometric measurements were obtained, and salivary cortisol concentrations were analyzed using ELISA. Statistical analyses included Mann-Whitney U, Kruskal-Wallis, and one-way ANOVA tests. The mean salivary cortisol concentration among students was 69.713 ± 3.408 ng/mL. Students reporting lower stress levels exhibited lower cortisol concentrations (p = 0.025), while cortisol did not differ significantly by gender, department, chronotype, BMI, or exercise status (p > 0.05). Emotional eating scores were significantly higher among students with intermediate chronotypes and those with irregular or occasionally regular sleep patterns (p < 0.05), whereas nutrition and dietetics students demonstrated more positive healthy nutrition attitudes than nursing students (75.52 ± 10.80 vs. 70.65± 10.08; p = 0.001). These findings reflect associations rather than causal relationships, and they highlight the relevance of circadian rhythm characteristics and perceived stress in understanding emotional eating tendencies and health-related attitudes among university students. Promoting sleep regularity, stress management, and nutrition education may support healthier behavioral patterns in this population.

昼夜节律、饮食态度和压力反应是大学生健康的重要决定因素。本研究假设昼夜节律特征与情绪化饮食、健康营养态度和唾液皮质醇水平有关。因此，本横断面研究调查了213名大学生的睡眠类型、睡眠模式、饮食行为和皮质醇浓度之间的关系（131名护士；82名营养和饮食）。采用早晚性问卷、情绪进食问卷（EEQ-TR）和健康营养态度量表（ASHN）收集数据。获得人体测量值，并使用ELISA分析唾液皮质醇浓度。统计分析包括Mann-Whitney U、Kruskal-Wallis检验和单因素方差分析。学生唾液皮质醇平均浓度为69.713±3.408 ng/mL。报告压力水平较低的学生表现出较低的皮质醇浓度（p = 0.025），而皮质醇在性别、系、时型、BMI或运动状态方面没有显着差异（p > 0.05）。睡眠模式不规律或偶尔有规律的学生情绪饮食得分显著高于中等睡眠类型的学生（p < 0.05），而营养与饮食专业的学生比护理专业的学生表现出更积极的健康营养态度（75.52±10.80∶70.65±10.08;p = 0.001）。这些发现反映了关联而不是因果关系，它们强调了昼夜节律特征和感知压力在理解大学生情绪化饮食倾向和健康相关态度方面的相关性。促进睡眠规律、压力管理和营养教育可以支持这一人群更健康的行为模式。

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引用次数: 0

Continuous testosterone exposure alters body weight, lean mass, estrous cycling and lipid profile, but not wheel running in adolescent or adult female rats 持续的睾酮暴露改变了青春期或成年雌性大鼠的体重、瘦质量、发情周期和脂质特征，但对轮跑没有影响。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-13 DOI: 10.1016/j.physbeh.2025.115206

Rebecca M. Craft, Alexa R. Calvert, Faith Spencer, Michael M. Morgan

Health-related organizations have called for broadening biomedical research to include gender-diverse individuals. The present study tested the validity of an animal model of gender affirming testosterone therapy that may be useful for determining the impact of hormonal transition on a variety of health outcomes in both adolescents and adults. Blank or testosterone-filled capsules were implanted s.c. into gonadally intact adolescent (post-natal day 43) and adult (post-natal day 92) female rats. Body weight, estrous cycling, and home cage wheel running were recorded for 3 weeks; other physiological indices of defeminization and masculinization were assessed 29–30 days after capsule implantation. Testosterone treatment at male-typical levels suppressed estrous cycling and uterine weight, increased body weight and lean mass, and increased low density lipoprotein levels in both adolescents and adults. Testosterone increased clitoral gland size in adolescents. In contrast, wheel running was not significantly altered by testosterone. Results suggest that testosterone exposure at male-typical levels in gonadally intact female rats – whether adolescent or adult at the initiation of treatment – is a valid model of gender affirming testosterone therapy in terms of hormone impact on a variety of physiological measures. This model can thus provide a clinically relevant avenue for advancing transgender medicine.

与健康有关的组织呼吁扩大生物医学研究，以包括性别不同的个人。本研究测试了性别确认睾酮治疗的动物模型的有效性，该模型可能有助于确定激素转换对青少年和成年人各种健康结果的影响。将空白或充满睾酮的胶囊植入性腺完整的青春期（出生后43天）和成年（出生后92天）雌性大鼠体内。记录体重、动情周期、笼轮跑3周；在胶囊植入后29-30天，观察小鼠去女性化和男性化的其他生理指标。在青少年和成人中，男性典型水平的睾酮治疗抑制了发情周期和子宫重量，增加了体重和瘦质量，并增加了低密度脂蛋白水平。睾酮增加了青少年阴蒂腺的大小。相比之下，滚轮跑步并没有受到睾丸激素的显著影响。结果表明，在性腺完整的雌性大鼠中，无论在治疗开始时是青春期还是成年，睾酮暴露在雄性典型水平上，就激素对各种生理指标的影响而言，是一种有效的性别肯定睾酮治疗模型。因此，该模型可以为推进跨性别医学提供临床相关的途径。

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引用次数: 0

Alteration of brain endocannabinoids on restraint stress-induced anxiety-like behaviors in mice 脑内源性大麻素对小鼠抑制应激诱导的焦虑样行为的影响。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-11 DOI: 10.1016/j.physbeh.2025.115201

Ryo Fukumori, Kanan Ueo, Ryosuke Nakashima, Taku Yamaguchi

Endocannabinoid (eCB) systems have been implicated in the development of stress-induced anxiety. In this study, we investigated the changes in eCB levels in the mouse brain due to restraint stress. In addition, we examined the effects of eCB-degrading enzyme inhibitors on anxiety-like behavior in restraint-stressed mice. For restraint stress, the mice were immobilized in a 50 ml syringe with holes for airflow for 30 min. After restraint stress, the contents of 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA) were measured via UPLC‒MS/MS. Immediately after restraint stress, 2-AG content was significantly decreased in the prefrontal cortex (PFC) and hippocampus (HC). Similarly, AEA content was decreased in the PFC and HC, although 2-AG and AEA contents did not change in the striatum, periamygdaloid cortex or medulla oblongata. On the other hand, at both 30 and 60 min after restraint stress, 2-AG content was significantly increased in the PFC and HC. However, AEA content remained reduced in the PFC for up to 30 min after stress exposure, but the significant reduction was no longer observed at 60 min. In the elevated plus-maze test, the time spent in the open arms decreased in restraint-stressed mice, which indicated the occurrence of anxiogenic behavior. This anxiogenic behavior was ameliorated by the administration of JZL184 (a monoacylglycerol lipase inhibitor) or URB597. (a fatty acid amide hydrolase inhibitor) These results suggest that eCB levels are highly responsive to time-dependent and brain region-specific changes in response to acute stress stimuli. Furthermore, restraint stress induces anxiogenic behavior, which is ameliorated by inhibitors of eCB-degrading enzymes. These findings indicate that the reduction in eCB levels in the PFC and HC may be due to the development of stress-induced anxiety.

内源性大麻素（eCB）系统与压力诱发焦虑的发展有关。在这项研究中，我们研究了约束应激引起的小鼠大脑中eCB水平的变化。此外，我们研究了ecb降解酶抑制剂对抑制应激小鼠焦虑样行为的影响。对于约束应激，将小鼠固定在50 ml带气孔的注射器中30分钟。抑制后，采用UPLC-MS /MS法测定2-花生四烯酰基甘油（2-AG）和n -花生四烯酰基乙醇胺（AEA）的含量。约束应激后，大鼠前额皮质（PFC）和海马（HC）中2-AG含量显著降低。同样，在PFC和HC中，AEA含量降低，但在纹状体、杏仁核周围皮层和延髓中，2-AG和AEA含量没有变化。另一方面，在抑制应激后30和60 min， PFC和HC中的2-AG含量均显著增加。然而，应激暴露后30分钟，PFC中的AEA含量仍在减少，但在60分钟后不再观察到明显的减少。在升高+迷宫实验中，约束应激小鼠张开双臂的时间减少，表明出现了焦虑行为。给药JZL184（一种单酰基甘油脂肪酶抑制剂）或URB597可改善这种焦虑行为。这些结果表明，在急性应激刺激下，eCB水平对时间依赖性和脑区域特异性变化有高度反应。此外，抑制应激诱导焦虑行为，这可以通过抑制ecb降解酶来改善。这些发现表明，PFC和HC中eCB水平的降低可能是由于压力诱发的焦虑的发展。

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引用次数: 0

Sexual activity before exercise influences physiological response and sports performance in high-level trained men athletes 运动前性行为影响高水平男性运动员的生理反应和运动表现。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-11 DOI: 10.1016/j.physbeh.2025.115203

Diego Fernández-Lázaro , Manuel Garrosa , Gema Santamaría , Enrique Roche , José María Izquierdo , Jesús Seco-Calvo , Juan Mielgo-Ayuso

Background

The influence of sexual activity prior to exercise on athletic performance remains controversial. While pre-competition abstinence is commonly advised, scientific evidence on its physiological impact is limited and inconsistent.

Methods

A randomized crossover study was conducted in 21 well-trained male athletes (age 22 ± 1 y) to compare the acute effects of masturbation-induced orgasm versus sexual abstinence performed 30 min before testing. Each participant completed an incremental cycling test and an isometric handgrip strength test under both conditions. Blood samples were analyzed for muscle damage (CK, LDH, Mb), inflammatory (CRP, IL-6), and hormonal (testosterone, cortisol, LH) markers.

Results

Compared with abstinence, the post-masturbation condition resulted in a longer exercise duration (+3.2%, p< 0.01) and higher heart rate (p< 0.001), accompanied by a small increase in mean handgrip strength (p< 0.05). Lower plasma LDH levels (p< 0.001) indicated reduced muscle stress. Testosterone and cortisol concentrations were significantly higher (both p< 0.001), whereas inflammatory markers (CRP, IL-6) showed no significant change.

Conclusions

Masturbation 30 min before exercise elicited mild sympathetic and hormonal activation without detrimental effects on performance or muscle damage. These findings suggest that pre-exercise sexual activity does not impair athletic capacity in trained men, challenging the long-standing myth of mandatory abstinence before competition.

背景：运动前性行为对运动成绩的影响仍有争议。虽然赛前禁欲通常被建议，但其生理影响的科学证据有限且不一致。方法：对21名训练有素的男性运动员（22±1岁）进行随机交叉研究，比较在测试前30分钟进行自慰性高潮和性禁欲的急性效果。在两种情况下，每个参与者都完成了增量循环测试和等长握力测试。分析血液样本的肌肉损伤（CK、LDH、Mb）、炎症（CRP、IL-6）和激素（睾酮、皮质醇、LH）标志物。结果：与禁欲相比，自慰后运动时间延长（+3.2%,p < 0.01），心率提高（p < 0.001），平均握力略有增加（p < 0.05）。较低的血浆LDH水平（p < 0.001）表明肌肉应激减轻。睾酮和皮质醇浓度显著升高（均p < 0.001），而炎症标志物（CRP, IL-6）无显著变化。结论：运动前30分钟手淫引起轻度交感神经和激素激活，但对运动表现或肌肉损伤没有不利影响。这些发现表明，运动前的性行为不会损害受过训练的男性的运动能力，挑战了长期以来关于比赛前强制禁欲的神话。

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引用次数: 0

Preliminary exploration of the role and mechanism of BAIAP2 in learning and memory impairment in ADHD BAIAP2在ADHD学习记忆障碍中的作用及机制初探

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-11 DOI: 10.1016/j.physbeh.2025.115202

Tian Tian , Yang Wang , Xu Xu , Jing Li , Jingbo Feng , Youfang Hu , Jirong Qi

Attention deficit hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder affecting children, presents with core symptoms of inattention, hyperactivity, and impulsivity, along with frequent comorbid learning and memory dysfunction. Emerging evidence implicates hippocampal dysfunction in ADHD-related learning and memory deficits, with brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) emerging as a critical molecular player. While BAIAP2 has been independently associated with synaptic plasticity and ADHD pathogenesis, its specific role in ADHD-associated learning and memory impairment remains unexplored.

Using spontaneously hypertensive rats (SHR), we demonstrated significantly reduced hippocampal BAIAP2 expression compared to controls. Notably, methylphenidate (MPH) treatment increased BAIAP2 levels, while targeted BAIAP2 overexpression rescued learning and memory deficits, as evidenced by Morris water maze (MWM) performance. Furthermore, we preliminarily explored the possible regulatory interactions between BAIAP2 and the long non-coding RNA lncNONRATT002035.2.

These findings establish BAIAP2 as a pivotal mediator of hippocampal-dependent learning and memory dysfunction in ADHD and uncovered new aspects of disease pathology and potential targets for therapy.The newly discovered lncNONRATT002035.2-BAIAP2 axis warrants further investigation to elucidate its pathophysiological significance.

注意缺陷多动障碍（ADHD）是一种影响儿童的高度普遍的神经发育障碍，其核心症状为注意力不集中、多动和冲动，并伴有常见的学习和记忆功能障碍。新出现的证据表明，海马功能障碍与多动症相关的学习和记忆缺陷有关，而BAIAP2（脑特异性血管生成抑制剂1-相关蛋白2）是一个关键的分子参与者。虽然BAIAP2与突触可塑性和ADHD发病机制独立相关，但其在ADHD相关的学习和记忆障碍中的具体作用尚不清楚。使用自发性高血压大鼠（SHR），我们发现与对照组相比，海马BAIAP2表达显著降低。值得注意的是，哌醋甲酯（MPH）处理增加了BAIAP2水平，而靶向BAIAP2过表达可改善学习和记忆缺陷，莫里斯水迷宫（MWZ）的表现证明了这一点。此外，我们初步探索了BAIAP2与长链非编码RNA lnnonratt002035.2之间可能的调控相互作用。这些发现证实了BAIAP2是ADHD患者海马体依赖性学习和记忆功能障碍的关键介质，并揭示了疾病病理和潜在治疗靶点的新方面。新发现的lnnonratt002035.2 - baiap2轴值得进一步研究以阐明其病理生理意义。

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引用次数: 0

An energy-efficient cognitive strategy? Neurophysiological dynamics of “slow but steady” attention in high-altitude Tibetans 节能认知策略？

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-11 DOI: 10.1016/j.physbeh.2025.115204

Xiao-Yan Huang , Nian-Nian Wang , Jing Zhou , Rui Su , Hao Li , Hai-Lin Ma , Ming Liu , De-Long Zhang

Indigenous Tibetans have developed documented physiological and neuroanatomical adaptations to high-altitude environments. However, the functional dynamics of their cognitive processing at such altitudes remain poorly characterized. To address this gap, we employed a visual search paradigm with high-temporal-resolution electroencephalography (EEG) to examine stimulus-driven attention (SDA) and goal-directed attention (GDA) in high-altitude Tibetans, with sea-level Han participants as a comparison group. Tibetans exhibited a “slow but steady” attentional pattern: despite longer reaction times (RTs), accuracy remained high (>95 %) and was comparable to that of Han controls in both attention types. This behavioral pattern in the Tibetan group was accompanied by distinctive late‑stage neural dynamics, reflected by smaller late positive potential (LPP) and late posterior negativity (LPN) and by lower theta‑band (4 - 10 Hz) event-related synchronization (ERS) during SDA, as well as smaller LPP during GDA. Source localization of the effects observed in these event-related potential (ERP) components and theta‑band ERS indicated predominant involvement of posterior midline and control-related regions in Han participants, whereas Tibetans showed greater engagement of motor‑related regions. These findings likely reflect an energy-efficient cognitive strategy for high-altitude adaptation. This study refines understanding of cognitive plasticity in extreme environments and provides electrophysiological foundations to inform interventions for high-altitude populations.

然而，在这样的高度，他们的认知加工的功能动态仍然缺乏特征。这些发现可能反映了高海拔适应的节能认知策略。该研究完善了对极端环境下认知可塑性的理解，并为高海拔人群的干预提供了电生理学基础。

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引用次数: 0

The combination of physical activity and late-time-restricted eating improves eating behavior, cognitive performance and cardiovascular parameters in women living with excess body weight 体育锻炼和晚进食限制相结合可以改善超重女性的饮食行为、认知能力和心血管参数。

IF 2.5 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-12-09 DOI: 10.1016/j.physbeh.2025.115200

Sarra Miladi , Omar Hammouda , Samar J. Miladi Trabelsi , Sirine C. Miladi , Ranya Ameur , Tarak Driss

To evaluate the combined effect of physical activity (PA) and time-restricted eating (TRE) at different times of day (early (ETRE) versus late (LTRE) TRE) on eating behavior, cognitive performance, and cardiovascular parameters in women living with overweight or obesity.

Sixty one women were randomized into four groups: ETRE combined with PA (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 ± 13.40 kg, 33.5 ± 5.53 kg/m²), LTRE combined with PA (LTRE-PA, n = 15, 30.60 ± 7.94 years, 94.45 ± 15.36 kg, 34.37 ± 7.09 kg/m²), LTRE alone (LTRE, n = 15, 27.93 ± 9.79 years, 88.32 ± 10.36 kg, 32.71 ± 5.15 kg/m²) and a control group (CG, n = 16, 36.25 ± 11.52 years, 89.01 ± 11.68 kg, 33.66 ± 6.18 kg/m²).

In the post-intervention assessment (T1), ETRE-PA showed a significant reduction in eating disorder global scores compared with LTRE (p = 0.01) and CG (p < 0.0005). In addition, ETRE-PA demonstrated greater vigilance performance compared with LTRE-PA (p = 0.003), LTRE (p < 0.0005), and CG (p < 0.0005) in T1. Both ETRE-PA and LTRE-PA enhanced global cognition compared with LTRE and CG (p < 0.0005) in T1.

For cardiometabolic outcomes, ETRE-PA improved oxygen saturation compared with LTRE (p = 0.005) and CG (p = 0.03). Resting heart rate was reduced in both ETRE-PA and LTRE-PA compared with LTRE (p = 0.009 and p = 0.03, respectively).

Combining ETRE with PA produced greater improvements in eating behavior, cognitive function, oxygen saturation, and cardiometabolic health than LTRE-PA, LTRE, or CG. These findings highlight the importance of aligning dietary timing with exercise to optimize health outcomes in women living with excess body weight.

评估一天中不同时间(早（早）和晚（晚（晚））的身体活动（PA）和限时饮食（TRE）对超重或肥胖女性饮食行为、认知表现和心血管参数的综合影响。61名妇女随机分为4组：ETRE联合PA组（ETRE-PA, n=15、31.8±10.76年、89.68±13.40 kg、33.5±5.53 kg/m²）、LTRE联合PA组（ETRE-PA, n=15、30.60±7.94年、94.45±15.36 kg、34.37±7.09 kg/m²）、LTRE单独组（LTRE, n=15、27.93±9.79年、88.32±10.36 kg、32.71±5.15 kg/m²）和对照组（CG, n=16、36.25±11.52年、89.01±11.68 kg、33.66±6.18 kg/m²）。在干预后评估（T1）中，与LTRE （p=0.01）和CG （p=0.01）相比，etr - pa在饮食失调总体评分方面显著降低（p=0.01）

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