Pub Date : 2021-12-30DOI: 10.37321/ujmh.2021.1-2-04
Дмитро Мальцев
Обґрунтування. Результати п’яти мета-аналізів рандомізованих контрольованих клінічних досліджень свідчать про асоціацію генетичного дефіциту фолатного циклу (ГДФЦ) і розладів спектру аутизму (РАС) у дітей. В таких випадках формується імунодефіцит та імунна дисрегуляція, що знижує резистентність до деяких мікроорганізмів.Мета дослідження: вивчити структуру мікробного спектру у дітей з РАС, пов’язаними з ГДФЦ, згідно з накопиченою дотепер доказовою базою і вивчити асоціацію виявлених мікроорганізмів з показниками імунного статусу для покращення розуміння патогенезу енцефалопатії та удосконалення алгоритмів діагностики, моніторингу і лікування.Матеріали і методи. Ретроспективно проаналізовано медичні дані 225 дітей віком від 2 до 9 років з ГДФЦ, у яких відзначалися клінічні прояви за типом РАС (досліджувана група; ДГ; 183 хлопчиків і 42 дівчинки). До контрольної групи (КГ) віднесли 51 клінічно здорову дитину (37 хлопчиків та 14 дівчаток) аналогічного вікового розподілу, які не страждали на ГДФЦ. Спеціальне лабораторне обстеження дітей груп спостереження проводили з урахуванням сучасних уявлень щодо мікробного спектру у пацієнтів з РАС згідно з публікаціями в PubMed і Embase. Для вивчення асоціацій між досліджуваними показниками застосовували показник відношення шансів (odds ratio, OR) та 95% довірчий інтервал (95% СІ). Дослідження виконувалося як фрагмент науково-дослідної роботи на замовлення МОЗ України (№ держреєстрації 0121U107940).Результати та їх обговорення. TTV відзначався в 87%, HHV-7 – 79%, HHV-6 – 68%, EBV – 59%, Streptococcus pyogenes – 46%, Candida albicans – 41%, Borrelia – 34%, Mycoplasma pneumoniae – 27%, Chlamydia pneumoniae – 26%, Yersinia enterocolitica – 23%, Toxoplasma gondii – 19%, перенесена природжена CMV нейроінфекція – 7%, наслідки HSV-1/2-нейро-інфекції – 5% випадків в ДГ (р<0,05; Z
{"title":"РЕЗУЛЬТАТИ ВИВЧЕННЯ МІКРОБНОГО СПЕКТРУ У ДІТЕЙ З РОЗЛАДАМИ СПЕКТРУ АУТИЗМУ, АСОЦІЙОВАНИМИ З ГЕНЕТИЧНИМ ДЕФІЦИТОМ ФОЛАТНОГО ЦИКЛУ","authors":"Дмитро Мальцев","doi":"10.37321/ujmh.2021.1-2-04","DOIUrl":"https://doi.org/10.37321/ujmh.2021.1-2-04","url":null,"abstract":"Обґрунтування. Результати п’яти мета-аналізів рандомізованих контрольованих клінічних досліджень свідчать про асоціацію генетичного дефіциту фолатного циклу (ГДФЦ) і розладів спектру аутизму (РАС) у дітей. В таких випадках формується імунодефіцит та імунна дисрегуляція, що знижує резистентність до деяких мікроорганізмів.Мета дослідження: вивчити структуру мікробного спектру у дітей з РАС, пов’язаними з ГДФЦ, згідно з накопиченою дотепер доказовою базою і вивчити асоціацію виявлених мікроорганізмів з показниками імунного статусу для покращення розуміння патогенезу енцефалопатії та удосконалення алгоритмів діагностики, моніторингу і лікування.Матеріали і методи. Ретроспективно проаналізовано медичні дані 225 дітей віком від 2 до 9 років з ГДФЦ, у яких відзначалися клінічні прояви за типом РАС (досліджувана група; ДГ; 183 хлопчиків і 42 дівчинки). До контрольної групи (КГ) віднесли 51 клінічно здорову дитину (37 хлопчиків та 14 дівчаток) аналогічного вікового розподілу, які не страждали на ГДФЦ. Спеціальне лабораторне обстеження дітей груп спостереження проводили з урахуванням сучасних уявлень щодо мікробного спектру у пацієнтів з РАС згідно з публікаціями в PubMed і Embase. Для вивчення асоціацій між досліджуваними показниками застосовували показник відношення шансів (odds ratio, OR) та 95% довірчий інтервал (95% СІ). Дослідження виконувалося як фрагмент науково-дослідної роботи на замовлення МОЗ України (№ держреєстрації 0121U107940).Результати та їх обговорення. TTV відзначався в 87%, HHV-7 – 79%, HHV-6 – 68%, EBV – 59%, Streptococcus pyogenes – 46%, Candida albicans – 41%, Borrelia – 34%, Mycoplasma pneumoniae – 27%, Chlamydia pneumoniae – 26%, Yersinia enterocolitica – 23%, Toxoplasma gondii – 19%, перенесена природжена CMV нейроінфекція – 7%, наслідки HSV-1/2-нейро-інфекції – 5% випадків в ДГ (р<0,05; Z<Z0,05). HHV-6, HHV-7 та EBV були асоційовані з дефіцитами NK-, NKT- та СD8+ цитотоксичних Т-лімфоцитів. ТТV також був асоційований з дефіцитами NK- та NKT-лімфоцитів, однак не з дефіцитом СD8+ цитотоксичних Т-клітин. Стрептококова інфекція була пов’язана з гіпо- і дисімуноглобулінемією, а також – дефіцитом мієлопероксидази. Кандидоз був асоційований тільки з дефіцитом мієлопероксидази. Токсоплазмоз відзначався при дефіциті СD4+ Т-хелперів та комбінованих порушеннях імунітету. Наслідки природженої CMV-нейроінфекції мали місце тільки при комбінованих порушеннях імунітету. Висновки. Для дітей з РАС, асоційованими з ГДФЦ, характерним є специфічний мікробний спектр з переважанням інтрацелюлярних опортуністичних та умовно патогенних мікроорганізмів, який визначається особливостями порушень в імунному статусі, спровокованих ГДФЦ, що має визначати алгоритм раціонального мікробіологічногопошуку, оцінки імунного статусу, проведення антимікробного та імунотропного лікування.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133118599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.37321/ujmh.2021.1-2-03
Вікторія Макоїд
метою вивчення особливостей ЕЕГ головного мозку при вперше виявленому депресивному епізоді протягом 2019-2021 рр. з дотриманням принципів біоетики на підставі інформованої згоди було обстежено 73 хворих (35 чоловіків і 38 жінок) із вперше виявленим депресивним епізодом, які звернулися за амбулаторною психіатричною допомогою.Матеріали та методи. Для вирішення поставленої мети були використані клініко-анамнестичний, клініко-психопатологічний, психодіагностичний, нейрофізіологічний та статистичний методи.За результатами дослідження було встановлено, що у переважної більшості обстежених (78,4%) вперше виявлений депресивний епізод характеризувався зниженням системної і когерентної взаємодії задньоскроневих і окціпітальних відділів лівої півкулі з правими лобними відділеннями, в поєднанні з підвищенням їх загальної активності.Також було встановлено прямий кореляційний зв’язок між ступенем виразності клінічних проявів депресивного розладу та підвищенням активності правобічних лобових і лівих потиличних відділів в поєднанні з посиленням загальної дисфункції глибинних структур головного мозку.Висновки. У пацієнтів із середнім та високим рівнем депресії в потиличній області кори лівої півкулі встановлений стійкий фокус підвищеної альфа-активності у поєднанні з підвищенням гамма-активності в правій лобній ділянці. Крім цього, у пацієнтів з виразними клінічними ознаками депресивного синдрому встановлено стійке збільшення потужності високочастотних діапазонів за показниками середньої спектральної потужності ритмів ЕЕГ, у порівняні з групою контролю.
{"title":"ЕЛЕКТРОЕНЦЕФАЛІЧНІ КОРЕЛЯТИ ПРИ ВПЕРШЕ ВИЯВЛЕНОМУ ДЕПРЕСИВНОМУ ЕПІЗОДІ","authors":"Вікторія Макоїд","doi":"10.37321/ujmh.2021.1-2-03","DOIUrl":"https://doi.org/10.37321/ujmh.2021.1-2-03","url":null,"abstract":"метою вивчення особливостей ЕЕГ головного мозку при вперше виявленому депресивному епізоді протягом 2019-2021 рр. з дотриманням принципів біоетики на підставі інформованої згоди було обстежено 73 хворих (35 чоловіків і 38 жінок) із вперше виявленим депресивним епізодом, які звернулися за амбулаторною психіатричною допомогою.Матеріали та методи. Для вирішення поставленої мети були використані клініко-анамнестичний, клініко-психопатологічний, психодіагностичний, нейрофізіологічний та статистичний методи.За результатами дослідження було встановлено, що у переважної більшості обстежених (78,4%) вперше виявлений депресивний епізод характеризувався зниженням системної і когерентної взаємодії задньоскроневих і окціпітальних відділів лівої півкулі з правими лобними відділеннями, в поєднанні з підвищенням їх загальної активності.Також було встановлено прямий кореляційний зв’язок між ступенем виразності клінічних проявів депресивного розладу та підвищенням активності правобічних лобових і лівих потиличних відділів в поєднанні з посиленням загальної дисфункції глибинних структур головного мозку.Висновки. У пацієнтів із середнім та високим рівнем депресії в потиличній області кори лівої півкулі встановлений стійкий фокус підвищеної альфа-активності у поєднанні з підвищенням гамма-активності в правій лобній ділянці. Крім цього, у пацієнтів з виразними клінічними ознаками депресивного синдрому встановлено стійке збільшення потужності високочастотних діапазонів за показниками середньої спектральної потужності ритмів ЕЕГ, у порівняні з групою контролю.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115294578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-14
Костянтин Аймедов, Валерій Наумов
Introduction. This work provides the results of author’s own research which are based on the analysis of characteristics of the post-stress personality disorders (PSD) taking into account the comorbid addictive behaviour among military personnel.During the study, it was found with PSD, the most pronounced addictions are cannabinoid, alcoholic and psychostimulants dependencies. Taking into account the tendency to increase number of people with psychopathological disorders and addictive behaviour manifestations in the modern Ukraine, the problem of prevention, treatment and support of people who were in the ATO area is acute now.Goal. Determination of markers of medical, psychological and social support.Research methods: theoretical, socio-demographic, clinical and psychopathological, psychodiagnostic, follow-up, clinical and anamnestic, statistical.Results. In order to develop a model of pharmacotherapy for this group of persons, during the 2014-2018 years, 219 people were examined at the age from 21 to 56 years, of which 18 persons were not included in the study according to the inclusion/exclusion criteria. Of surveyed people (201 persons), 59 people were diagnosed with PSD, including 32 people with comorbid adductions.We carried out a screening diagnostic assessment of the needs of servicemen, during which we identified the main requests for the need for corrective measures, their attitude and desire to take part in an experimental program to restore normal social life and restore normal life. According to the results of the study, it was found that the spectrum of needs covers all three spheres of a person’s life: biological, psychological and social. It was possible to identify the main targets of psychotherapy and draw up a plan of the main activities. The general goal of psychocorrectional measures for each of the studied groups was the restoration of normal processes of life of the individual and the restoration of normal social interaction.Conclusions. The developed measures gave us the opportunity to effectively influence all links of pathogenesis, based on the biopsychosocial model of addiction. In the process of treatment, taking into account the recommendations of the MOH on the treatment of military personnel, were improved certain stages of pharmacotherapy as the basis for further active psychosocial and psychosocial support, which will create the basis for the normalization of their livelihoods and the possibility of military-professional recovery.
{"title":"COMPLEX MEDICAL-PSYCHOLOGICAL AND SOCIAL SUPPORT OF PARTICIPANTS OF COMBAT","authors":"Костянтин Аймедов, Валерій Наумов","doi":"10.37321/ujmh.2020.1-2-14","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-14","url":null,"abstract":"Introduction. This work provides the results of author’s own research which are based on the analysis of characteristics of the post-stress personality disorders (PSD) taking into account the comorbid addictive behaviour among military personnel.During the study, it was found with PSD, the most pronounced addictions are cannabinoid, alcoholic and psychostimulants dependencies. Taking into account the tendency to increase number of people with psychopathological disorders and addictive behaviour manifestations in the modern Ukraine, the problem of prevention, treatment and support of people who were in the ATO area is acute now.Goal. Determination of markers of medical, psychological and social support.Research methods: theoretical, socio-demographic, clinical and psychopathological, psychodiagnostic, follow-up, clinical and anamnestic, statistical.Results. In order to develop a model of pharmacotherapy for this group of persons, during the 2014-2018 years, 219 people were examined at the age from 21 to 56 years, of which 18 persons were not included in the study according to the inclusion/exclusion criteria. Of surveyed people (201 persons), 59 people were diagnosed with PSD, including 32 people with comorbid adductions.We carried out a screening diagnostic assessment of the needs of servicemen, during which we identified the main requests for the need for corrective measures, their attitude and desire to take part in an experimental program to restore normal social life and restore normal life. According to the results of the study, it was found that the spectrum of needs covers all three spheres of a person’s life: biological, psychological and social. It was possible to identify the main targets of psychotherapy and draw up a plan of the main activities. The general goal of psychocorrectional measures for each of the studied groups was the restoration of normal processes of life of the individual and the restoration of normal social interaction.Conclusions. The developed measures gave us the opportunity to effectively influence all links of pathogenesis, based on the biopsychosocial model of addiction. In the process of treatment, taking into account the recommendations of the MOH on the treatment of military personnel, were improved certain stages of pharmacotherapy as the basis for further active psychosocial and psychosocial support, which will create the basis for the normalization of their livelihoods and the possibility of military-professional recovery.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133798740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-07
Роман Плохушко, Жанна Войтович
The purpose of this review is to highlight the present state of the problem of interconnection of psycho-emotional processes with the onset, clinical course and treatment of bronchial asthma.The current researches of domestic and foreign authors is analyzed and summarized. Bronchial asthma is considered by researchers as a psychosomatic disease. The characteristic psychoneural status of children with chronic obstructive syndrome is formulated and the dependence of psycho-emotional changes on the level of bronchial asthma control is shown.The importance of further study of the psychopathogenesis of emotional disorders associated with bronchial asthma is stated in order to develop more effective methods of therapy for these conditions.
{"title":"PSYCHOEMOTIONAL DISORDERS IN CHILDREN ASSOCIATED WITH BRONCHIAL ASTHMA","authors":"Роман Плохушко, Жанна Войтович","doi":"10.37321/ujmh.2020.1-2-07","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-07","url":null,"abstract":"The purpose of this review is to highlight the present state of the problem of interconnection of psycho-emotional processes with the onset, clinical course and treatment of bronchial asthma.The current researches of domestic and foreign authors is analyzed and summarized. Bronchial asthma is considered by researchers as a psychosomatic disease. The characteristic psychoneural status of children with chronic obstructive syndrome is formulated and the dependence of psycho-emotional changes on the level of bronchial asthma control is shown.The importance of further study of the psychopathogenesis of emotional disorders associated with bronchial asthma is stated in order to develop more effective methods of therapy for these conditions.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126007971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-05
Владислав Плєхов
A review of current literary sources on the problem of affective disorders in the structure of schizotypal disorder is carried out. The problem of nosological affiliation and semiotic content of this pathology is considered, its historiographic analysis is carried out. The issues of polymorphism of the clinical symptoms of schizotypal disorder are considered in detail and the psychosocial influence of the patho-affective component on the course and prognosis of the disease is characterized. The analysis of the most common means of therapy and correction of these disorders in patients with schizotypal disorder has been carried out.
{"title":"THE CURRENT STATE OF THE PROBLEM OF AFFECTIVE DISORDERS IN PATIENTS WITH SCHIZOTYPIC DISORDER","authors":"Владислав Плєхов","doi":"10.37321/ujmh.2020.1-2-05","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-05","url":null,"abstract":"A review of current literary sources on the problem of affective disorders in the structure of schizotypal disorder is carried out. The problem of nosological affiliation and semiotic content of this pathology is considered, its historiographic analysis is carried out. The issues of polymorphism of the clinical symptoms of schizotypal disorder are considered in detail and the psychosocial influence of the patho-affective component on the course and prognosis of the disease is characterized. The analysis of the most common means of therapy and correction of these disorders in patients with schizotypal disorder has been carried out.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124392849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-10
Ірина Романова, Тана Кришталь, Тетяна Селюкова
Aim of the study on the basis of study of abnormal psychology phenomenology to learn propensity to disorders of behavior and displays of disadaptation for teenagers, as a factor of origin and realization of different forms of victim behavior that can become reason of origin of propensity to the destructive options and tendencies of behavior in interpersonality relations for teenagers with a psychological deprivate and to work out fitting for their psychocorrection.Materials and methods. By us were inspected from 2018 to 2020 50 teenagers by age 16-18, that was brought up shelter of domestic type for the children of orphans and children confined of the paternal caring.Experimental psychological researches included: test of А.Н. Orel is for the exposure of indexes of propensity to disorders of behavior of teenagers, that sent to the estimation of readiness or inclination of teenagers to realization of different forms of deviative behavior; test of О.О. Andronikova for the exposure of indexes of propensity to victim behavior of teenagers.Results. As a result of this study, psychodiagnostics and psychocorrection were carried out to 50 teenagers with a psychological deprivate, it was educed greater propensity to victim behavior and characteristic intentionally creation or provocation of conflict situation for the pupils of refuge for children-orphans, than for teenagers that was brought up in families.Conclusions. On the basis of analysis of individual, personality, social-psychological factors, that stipulate forming of social psychological rejections in behavior of teenagers with psychological deprivation, necessary application of timely complex, psychocorrection, due to renewal for the teenagers of social psychological adaptation, also on psychoprophylaxis of forming of victim and aggressive character traits.
{"title":"PSYCHODIAGNOSTICS AND PSYCHOCORECTION OF BEHAVIORAL DISORDERS AND DISADAPTATION IN ADOLESCENTS WITH PSYCHOLOGICAL DEPRIVATION","authors":"Ірина Романова, Тана Кришталь, Тетяна Селюкова","doi":"10.37321/ujmh.2020.1-2-10","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-10","url":null,"abstract":"Aim of the study on the basis of study of abnormal psychology phenomenology to learn propensity to disorders of behavior and displays of disadaptation for teenagers, as a factor of origin and realization of different forms of victim behavior that can become reason of origin of propensity to the destructive options and tendencies of behavior in interpersonality relations for teenagers with a psychological deprivate and to work out fitting for their psychocorrection.Materials and methods. By us were inspected from 2018 to 2020 50 teenagers by age 16-18, that was brought up shelter of domestic type for the children of orphans and children confined of the paternal caring.Experimental psychological researches included: test of А.Н. Orel is for the exposure of indexes of propensity to disorders of behavior of teenagers, that sent to the estimation of readiness or inclination of teenagers to realization of different forms of deviative behavior; test of О.О. Andronikova for the exposure of indexes of propensity to victim behavior of teenagers.Results. As a result of this study, psychodiagnostics and psychocorrection were carried out to 50 teenagers with a psychological deprivate, it was educed greater propensity to victim behavior and characteristic intentionally creation or provocation of conflict situation for the pupils of refuge for children-orphans, than for teenagers that was brought up in families.Conclusions. On the basis of analysis of individual, personality, social-psychological factors, that stipulate forming of social psychological rejections in behavior of teenagers with psychological deprivation, necessary application of timely complex, psychocorrection, due to renewal for the teenagers of social psychological adaptation, also on psychoprophylaxis of forming of victim and aggressive character traits.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130303741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-12
Александр Книгавко
Aim: to study the long-term effectiveness of stimulation of the vein-occlusive mechanism by the addition of autologous stem cells and PRP therapy in the surgical removal of venous leak.Materials and Methods: comprehensive examination and treatment of 156 patients with vein-occlusive erectile dysfunction was carried out. Most of them – 112 (82.9%), – had left-sided or bilateral varicocele. In 86 patients of the first group with a proximal form of vein-occlusive erectile dysfunction, ligation of deep dorsal veins and veins of the penis and Marmara operation from a foam-pubic incision were performed. In 49 patients of the second group with a distal form of vein-occlusive erectile dysfunction, embolization of deep dorsal veins and veins of the Santorini plexus was performed through a conductor in the deep dorsal vein of the penis. To improve the venous occlusion mechanism, 1 million autologous endothelial stem cells and 2 millions autologous fibroblast stem cells were injected into each cavernous body, which were activated by vascular growth factor into the ligated veins (deep dorsal and large veins of the penis) in a retrograde direction during occlusive operations for 48 patients (groups 1b and 2b, respectively) and compared long-term results.Results: The effectiveness of surgical treatment according to subjective data (IIEF questionnaire) – after 2 months was almost equal, but after 18 months it was significantly higher in subgroups 1b and 2b (68,9% и 75,5) and according to objective data (no venous leakage with dopplerography of the penis), after 18 months in 73.4% and 91.4%, respectively.Conclusions: The use of autologous (endothelial and fibroblast) stem cells with the course of PRP therapy improves the veno-occlusive mechanism, increases the efficiency and long-term results of vein-occlusive surgeries for the treatment of VOED, creating an effective alternative to phalloprosthetics for men with this problem.
{"title":"MODERN METHODS OF CORRECTION OF VEIN-OCCLUSIVE ERECTILE DYSFUNCTION","authors":"Александр Книгавко","doi":"10.37321/ujmh.2020.1-2-12","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-12","url":null,"abstract":"Aim: to study the long-term effectiveness of stimulation of the vein-occlusive mechanism by the addition of autologous stem cells and PRP therapy in the surgical removal of venous leak.Materials and Methods: comprehensive examination and treatment of 156 patients with vein-occlusive erectile dysfunction was carried out. Most of them – 112 (82.9%), – had left-sided or bilateral varicocele. In 86 patients of the first group with a proximal form of vein-occlusive erectile dysfunction, ligation of deep dorsal veins and veins of the penis and Marmara operation from a foam-pubic incision were performed. In 49 patients of the second group with a distal form of vein-occlusive erectile dysfunction, embolization of deep dorsal veins and veins of the Santorini plexus was performed through a conductor in the deep dorsal vein of the penis. To improve the venous occlusion mechanism, 1 million autologous endothelial stem cells and 2 millions autologous fibroblast stem cells were injected into each cavernous body, which were activated by vascular growth factor into the ligated veins (deep dorsal and large veins of the penis) in a retrograde direction during occlusive operations for 48 patients (groups 1b and 2b, respectively) and compared long-term results.Results: The effectiveness of surgical treatment according to subjective data (IIEF questionnaire) – after 2 months was almost equal, but after 18 months it was significantly higher in subgroups 1b and 2b (68,9% и 75,5) and according to objective data (no venous leakage with dopplerography of the penis), after 18 months in 73.4% and 91.4%, respectively.Conclusions: The use of autologous (endothelial and fibroblast) stem cells with the course of PRP therapy improves the veno-occlusive mechanism, increases the efficiency and long-term results of vein-occlusive surgeries for the treatment of VOED, creating an effective alternative to phalloprosthetics for men with this problem.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114234692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-06
В. Л. Підлубний, Микола Хоміцький
The aim of the study. To study the literature in order to identify modern scientific views on the clinic, systematics, diagnosis and pathopersonalogy of endogenous psychoses with episodic course. Results. The analysis of the literature shows that the diagnostic and classification approaches of endogenous psychoses with episodic course, are focused on polymorphic and variable symptoms of exacerbation of the disease. This leads to diagnostic mistakes, errors in the appointment of maintenance therapy, deterioration of compliance and further deepening of social maladaptation of patients. Refusal to develop the mechanisms of pathogenesis on the basis of the nosological approach will inevitably lead to a regression of the level of treatment and rehabilitation approaches - from ethiopathogenetic to symptomatic. Conclusions. Thus, at present, the importance of diagnostic techniques aimed at assessing and differentiating persistent symptoms of the disease in the period of remission of endogenous psychoses and relate to pathopersonalogical transformations. Research and correct diagnostic assessment of this multicomponent cluster of psychopathological symptoms allows to assess the nosological affiliation of a particular clinical case and to determine the necessary pharmacological and social rehabilitation effects in order to correct existing pathopersonalogical transformations and prevent exacerbation of endogenous psychosis.
{"title":"MODERN SCIENTIFIC VIEWS ON THE CLINIC, SYSTEMATICS, DIAGNOSIS AND PATHOPERSONALOGY OF ENDOGENOUS PSYCHOSIS WITH EPISODIC COURSE (LITERATURE RIVIEW)","authors":"В. Л. Підлубний, Микола Хоміцький","doi":"10.37321/ujmh.2020.1-2-06","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-06","url":null,"abstract":"The aim of the study. To study the literature in order to identify modern scientific views on the clinic, systematics, diagnosis and pathopersonalogy of endogenous psychoses with episodic course. Results. The analysis of the literature shows that the diagnostic and classification approaches of endogenous psychoses with episodic course, are focused on polymorphic and variable symptoms of exacerbation of the disease. This leads to diagnostic mistakes, errors in the appointment of maintenance therapy, deterioration of compliance and further deepening of social maladaptation of patients. Refusal to develop the mechanisms of pathogenesis on the basis of the nosological approach will inevitably lead to a regression of the level of treatment and rehabilitation approaches - from ethiopathogenetic to symptomatic. Conclusions. Thus, at present, the importance of diagnostic techniques aimed at assessing and differentiating persistent symptoms of the disease in the period of remission of endogenous psychoses and relate to pathopersonalogical transformations. Research and correct diagnostic assessment of this multicomponent cluster of psychopathological symptoms allows to assess the nosological affiliation of a particular clinical case and to determine the necessary pharmacological and social rehabilitation effects in order to correct existing pathopersonalogical transformations and prevent exacerbation of endogenous psychosis.","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121047609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-09
Ramzi Parviz, R. Solomianyi, Y. Zasieda
Relevance. Male infertility is basic problem for several medical specialties from genetics and endocrinology to urology and andrology. It’s impact on personal quality of life, social functioning and existential aspects of well being and in larger scale on social health is dramatic.Aim – to develop and test complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate.Methods. The study was based on prospective parallel group design. The study contingent consisted of 46 patients of the “Men’s Health Clinic” Kiev, Ukraine, undergoing outpatient treatment for non-obstructive fertility disorders.Following methods were used: clinical (a standard set of clinical examinations to establish a preliminary diagnosis), laboratory (bacterial seeding of ejaculate for the presence of pathogenic microflora, extended spermogram); serological (evaluations of serum testosterone and luteinizing hormone levels instrumental (sonographic examination of the prostate gland in order exclude prostatic inflammation); statistical.Results. After the initial complex of examinations study contingent underwent developed treatment protocol: 6 sessions (1 session per week) of local injections of 1ml HPH «Laennec»; 6 sessions of local injections of 1ml PRP (1 session per week); 6 sessions of LIPUS (1 session per week, following HPH and PRP injections); metabolic therapy: «SaluFertil Forte» and «SALUTRIB» 6 weeks daily.Conclusion. Complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate and metabolic therapy with «SaluFertil Forte» and «SALUTRIB», showed significant efficacy in 6-week therapeutic period. Therapeutic effect was found in sperm count in 1 ml (<0,01), sperm aggregation (<0,01) and sperm mobility (group A + B) (<0,01).
{"title":"COMPLEX TREATMENT OF NON-OBSTRUCTIVE FORMS OF MALE INFERTILITY WITH PLATELET-RICH PLASMA, LOWINTENSITY PULSED ULTRASOUND AND HUMAN PLACENTA HYDROLYSATE","authors":"Ramzi Parviz, R. Solomianyi, Y. Zasieda","doi":"10.37321/ujmh.2020.1-2-09","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-09","url":null,"abstract":"Relevance. Male infertility is basic problem for several medical specialties from genetics and endocrinology to urology and andrology. It’s impact on personal quality of life, social functioning and existential aspects of well being and in larger scale on social health is dramatic.Aim – to develop and test complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate.Methods. The study was based on prospective parallel group design. The study contingent consisted of 46 patients of the “Men’s Health Clinic” Kiev, Ukraine, undergoing outpatient treatment for non-obstructive fertility disorders.Following methods were used: clinical (a standard set of clinical examinations to establish a preliminary diagnosis), laboratory (bacterial seeding of ejaculate for the presence of pathogenic microflora, extended spermogram); serological (evaluations of serum testosterone and luteinizing hormone levels instrumental (sonographic examination of the prostate gland in order exclude prostatic inflammation); statistical.Results. After the initial complex of examinations study contingent underwent developed treatment protocol: 6 sessions (1 session per week) of local injections of 1ml HPH «Laennec»; 6 sessions of local injections of 1ml PRP (1 session per week); 6 sessions of LIPUS (1 session per week, following HPH and PRP injections); metabolic therapy: «SaluFertil Forte» and «SALUTRIB» 6 weeks daily.Conclusion. Complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate and metabolic therapy with «SaluFertil Forte» and «SALUTRIB», showed significant efficacy in 6-week therapeutic period. Therapeutic effect was found in sperm count in 1 ml (<0,01), sperm aggregation (<0,01) and sperm mobility (group A + B) (<0,01).","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127949814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.37321/ujmh.2020.1-2-13
Валерій Володимирович Мінухін, Інна Торяник, Діана Валеріївна Мінухіна, Сергій Похил, Дмитро Мінухін, Олег Труфанов, Світлана Калітіна
The aim of the study was to investigate the structural and functional changes in the male genitourinary system in the development of cryptosporidiosis.Material and methods. The study was based on biopsies and necropsies, based on histological methods.Results. The article is devoted to the study of structural and functional changes in the male genitourinary system in the development of cryptosporidiosis. The authors of the study emphasize the features of the nomenclature profile of cryptosporidiosis, its low certainty, the place among modern protozoal infections. The paper draws attention to the emergence of the disease, the specifics of its clinical course, the characteristics of the most accessible and effective methodological (histological) algorithm. The publication presents data on structural and functional changes of the urethra, testicles, kidneys of children with cryptosporidiosis (proven participation of the inflammatory component, destructive processes, trophic disorders). Researchers have focused on the peculiarities of the structure of the mucous membranes of the genitourinary organs in terms of cryptosporidiosis, destruction of the epithelium, microcirculation disorders. It is assumed that the factors of influence / strengthening of the latter were the activation of lysosomal (hydrolytic) enzymes capable of cleaving lipid - protein complexes of membranes.As a result, the opinion is expressed about the role of cryptosporidiosis in the development of male infertility.Conclusions. In the case of cryptosporidiosis, the most vulnerable structures of the male genitourinary system are cells of mesenchymal origin (epithelium).They are characterized by atrophy, desquamation, destructive-degenerative changes, necrosis. The destruction of the endothelial layer of microvessels leads to defects in the layers of the walls of the latter, thrombosis, the development of stasis, impaired microcirculation and trophism
{"title":"REGULARITIES OF MORPHOLOGICAL CHANGES IN THE ORGANS OF THE MALE URINARY AND GENITAL SYSTEM IN CASE OF CRYPTOSPORIDIOSIS (generalized research materials)","authors":"Валерій Володимирович Мінухін, Інна Торяник, Діана Валеріївна Мінухіна, Сергій Похил, Дмитро Мінухін, Олег Труфанов, Світлана Калітіна","doi":"10.37321/ujmh.2020.1-2-13","DOIUrl":"https://doi.org/10.37321/ujmh.2020.1-2-13","url":null,"abstract":"The aim of the study was to investigate the structural and functional changes in the male genitourinary system in the development of cryptosporidiosis.Material and methods. The study was based on biopsies and necropsies, based on histological methods.Results. The article is devoted to the study of structural and functional changes in the male genitourinary system in the development of cryptosporidiosis. The authors of the study emphasize the features of the nomenclature profile of cryptosporidiosis, its low certainty, the place among modern protozoal infections. The paper draws attention to the emergence of the disease, the specifics of its clinical course, the characteristics of the most accessible and effective methodological (histological) algorithm. The publication presents data on structural and functional changes of the urethra, testicles, kidneys of children with cryptosporidiosis (proven participation of the inflammatory component, destructive processes, trophic disorders). Researchers have focused on the peculiarities of the structure of the mucous membranes of the genitourinary organs in terms of cryptosporidiosis, destruction of the epithelium, microcirculation disorders. It is assumed that the factors of influence / strengthening of the latter were the activation of lysosomal (hydrolytic) enzymes capable of cleaving lipid - protein complexes of membranes.As a result, the opinion is expressed about the role of cryptosporidiosis in the development of male infertility.Conclusions. In the case of cryptosporidiosis, the most vulnerable structures of the male genitourinary system are cells of mesenchymal origin (epithelium).They are characterized by atrophy, desquamation, destructive-degenerative changes, necrosis. The destruction of the endothelial layer of microvessels leads to defects in the layers of the walls of the latter, thrombosis, the development of stasis, impaired microcirculation and trophism","PeriodicalId":204320,"journal":{"name":"Men’s Health, Gender and Psychosomatic Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129878531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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