{"title":"Visualization of water dynamics in brain tissue using multiphoton multimodal imaging","authors":"Takanori Shinotsuka, Tsuyoshi Miyazawa, Keiko Karasawa, Yasuyuki Ozeki, Masato Yasui, M. Nuriya","doi":"10.1254/jpssuppl.96.0_2-b-o05-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-o05-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88372174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CaMKII inhibition prevents the Dox-induced mitochondrial dysfunction without the involvement of Drp1 or MCU","authors":"A. Priyono, Jun-ichiro Miake, Yasunori Ichihara, Tatsuya Sawano, Keiko Nagata, Takeshi Imamura","doi":"10.1254/jpssuppl.96.0_2-b-ss01-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-ss01-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86270469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-p-241
Y. Nishimoto, Daiki Ando, Kosuke Irie, Ikumi Kainuma, Y. Katayama, Shiori Sato, Tomohiro Suzuki, Mai Harada, T. Yoshida, Genki Kimura, Kazuhiro Ito, Y. Kizawa
{"title":"The effects of dasatinib on corticosteroid insensitive airway inflammation in mice induced by tobacco smoke","authors":"Y. Nishimoto, Daiki Ando, Kosuke Irie, Ikumi Kainuma, Y. Katayama, Shiori Sato, Tomohiro Suzuki, Mai Harada, T. Yoshida, Genki Kimura, Kazuhiro Ito, Y. Kizawa","doi":"10.1254/jpssuppl.96.0_3-b-p-241","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-241","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86447226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-o06-2
F. Nakamura, Miyu Wakatsuki, Kohtaro Takizawa, Aoi Jitsuki-Takahash
{"title":"Involvement of Protein tyrosine phosphatase delta (PTPd) in the cortical pyramidal dendritic growth of through the regulation of Signal Regulatory Protein alpha (SIRPa) phosphorylation.","authors":"F. Nakamura, Miyu Wakatsuki, Kohtaro Takizawa, Aoi Jitsuki-Takahash","doi":"10.1254/jpssuppl.96.0_3-b-o06-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-o06-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86082481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_1-b-ss03-4
N. Hori, Takayuki Suzuki, T. Araki, Chinatsu Ishikawa, Anri Nasuhara, H. Takano, N. Yamaguchi
{"title":"The Hippo pathway kinase Lats1/2 inhibition increases slow- and fast-twitch fibers via activation of Tead cofactors.","authors":"N. Hori, Takayuki Suzuki, T. Araki, Chinatsu Ishikawa, Anri Nasuhara, H. Takano, N. Yamaguchi","doi":"10.1254/jpssuppl.96.0_1-b-ss03-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-ss03-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83977818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-ss-14
Hashiguchi Kohei, Y. Kambe, Mitsutaka Sugimura, T. Kurihara, A. Miyata
Recent evidence has suggested that pituitary adenylate cyclase-activating polypeptide (PACAP) has critical roles in central and peripheral pathways, such as spino-parabrachio-amygdaloid and hypothalamic-pituitary-adrenal pathways, mediating stress-related negative emotional behaviors. Although it is well established that there is a great degree of comorbidity of chronic pain and negative emotional behaviors, the cellular mechanism underlying chronic pain and anxiety/depression interaction still remains to be elucidated. Here, we evaluated possible involvement of PACAP signaling in the development of anxiety- and depression-like behaviors after peripheral nerve injury in mice. We observed that spinal nerve ligation (SNL) induced anxiety- and depression-like behaviors lasting for at least 3 weeks in wild-type (PACAP +/+) mice. However, the development of SNL-induced anxiety- and depression-like behaviors was almost completely abrogated in PACAP -/- mice. Furthermore, we found that selective overexpression of PACAP by the infection of adeno-associated virus in the hypothalamic paraventricular nucleus (PVN), but not neighboring ventromedial hypothalamus, region resulted in the induction of anxiety-like behavior. In contrast, siRNA-mediated knockdown of PVN PACAP attenuated the development of SNL-induced anxiety- but not depressive-like behavior. Our data support that PVN PACAP signaling is involved in an important mechanism underlying the anxiety-like behaviors in peripheral neuropathic pain condition.
{"title":"Possible involvement of hypothalamic paraventricular nucleus PACAP in chronic pain-induced negative emotional responses in mice","authors":"Hashiguchi Kohei, Y. Kambe, Mitsutaka Sugimura, T. Kurihara, A. Miyata","doi":"10.1254/jpssuppl.95.0_1-ss-14","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-14","url":null,"abstract":"Recent evidence has suggested that pituitary adenylate cyclase-activating polypeptide (PACAP) has critical roles in central and peripheral pathways, such as spino-parabrachio-amygdaloid and hypothalamic-pituitary-adrenal pathways, mediating stress-related negative emotional behaviors. Although it is well established that there is a great degree of comorbidity of chronic pain and negative emotional behaviors, the cellular mechanism underlying chronic pain and anxiety/depression interaction still remains to be elucidated. Here, we evaluated possible involvement of PACAP signaling in the development of anxiety- and depression-like behaviors after peripheral nerve injury in mice. We observed that spinal nerve ligation (SNL) induced anxiety- and depression-like behaviors lasting for at least 3 weeks in wild-type (PACAP +/+) mice. However, the development of SNL-induced anxiety- and depression-like behaviors was almost completely abrogated in PACAP -/- mice. Furthermore, we found that selective overexpression of PACAP by the infection of adeno-associated virus in the hypothalamic paraventricular nucleus (PVN), but not neighboring ventromedial hypothalamus, region resulted in the induction of anxiety-like behavior. In contrast, siRNA-mediated knockdown of PVN PACAP attenuated the development of SNL-induced anxiety- but not depressive-like behavior. Our data support that PVN PACAP signaling is involved in an important mechanism underlying the anxiety-like behaviors in peripheral neuropathic pain condition.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82880486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-p-221
Naoko Yamaguchi, S. Okada
{"title":"Astrocytes in the PVN are involved in corticotropin-releasing factor-induced sympathetic activation in rats","authors":"Naoko Yamaguchi, S. Okada","doi":"10.1254/jpssuppl.96.0_3-b-p-221","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-221","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82810504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-s10-3
Ojida Akio
{"title":"Development of Highly Selective Covalent Inhibitors for Treatment of Cancers","authors":"Ojida Akio","doi":"10.1254/jpssuppl.95.0_1-s10-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-s10-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86781688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-s27-1
Ishii Takeo
Severe asthma, a part of difficult-to-treat asthma, represents a poorly controlled asthma despite maximally optimized treatment and its adherence. Uncontrolled asthma is judged by poor symptom control, frequent exacerbations requiring oral corticosteroids (OCS), or severe exacerbations requiring hospitalization. It is considered to be 5 percent or less of all asthmatics (GINA 2019).
{"title":"Treatment of asthma including intractable one; our challenge as a pharma and beyond","authors":"Ishii Takeo","doi":"10.1254/jpssuppl.95.0_2-s27-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-s27-1","url":null,"abstract":"Severe asthma, a part of difficult-to-treat asthma, represents a poorly controlled asthma despite maximally optimized treatment and its adherence. Uncontrolled asthma is judged by poor symptom control, frequent exacerbations requiring oral corticosteroids (OCS), or severe exacerbations requiring hospitalization. It is considered to be 5 percent or less of all asthmatics (GINA 2019).","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88956691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-s24-2
A. Sasaki
{"title":"Challenges in central nervous system drug development：What pharmaceutical corporations are seeking","authors":"A. Sasaki","doi":"10.1254/jpssuppl.95.0_2-s24-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-s24-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89198664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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