Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-s14-1
Kitaguchi Tetsuya
{"title":"Generation of genetically-encoded fluorescent sensors using molecular evolution and semi-rational molecular design","authors":"Kitaguchi Tetsuya","doi":"10.1254/jpssuppl.96.0_2-b-s14-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s14-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79286063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-p-082
Misaki Ishibane, M. Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito, Y. Reien, Yuri Hirayama, Hirofumi Hashimoto, N. Kuwata, H. Mitsuya, N. Anzai
In treatment of hepatitis B virus (HBV), it is usually difficult for us to control with emergence of drug resistance. As HBV often reactive after treatment was stopped, patients must keep it for long term. Recently, we have developed E-CFCP, as a candidate drug of HBV for patients with drug-resistant HBV. As it has high antiviral activity and the half-life also is longer, patients can take it in a once-weekly dosing. We expect that E-CFCP can greatly improve the quality of life of patients. However, effects of E-CFCP are unclear in renal. The aim of this study is to clarify the effects of E-CFCP in the kidney, especially organic acid transporter（Organic anion transporters：OATs, Organic cation transporter：OCT）. We conducted cell viability studies using mouse-derived renal cortical cells (S2, CCD, cTAL) and uptake studies using radioisotopes to determine the effects of E-CFCP on the kidneys. In cell viability studies, E-CFCP has no cytotoxicity in all cell lines. We also examined the effect of drugs at high concentration using S2 cells. E-CFCP has no cytotoxicity even at high concentrations. In the substrate uptake assay, there was no inhibition of substrate uptake by E-CFCP, the transporter is not involved in the intracellular transport of E-CFCP and is unlikely to cause cytotoxicity. In conclusion, E-CFCP, a novel HBV antiviral drug, is unlikely to cause renal damage. It may be a novel great candidate drug of HBV for patients with drug-resistant HBV.
{"title":"Effects of a novel hepatitis B antiviral drug in renal organic acid transporters","authors":"Misaki Ishibane, M. Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito, Y. Reien, Yuri Hirayama, Hirofumi Hashimoto, N. Kuwata, H. Mitsuya, N. Anzai","doi":"10.1254/jpssuppl.95.0_1-p-082","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-p-082","url":null,"abstract":"In treatment of hepatitis B virus (HBV), it is usually difficult for us to control with emergence of drug resistance. As HBV often reactive after treatment was stopped, patients must keep it for long term. Recently, we have developed E-CFCP, as a candidate drug of HBV for patients with drug-resistant HBV. As it has high antiviral activity and the half-life also is longer, patients can take it in a once-weekly dosing. We expect that E-CFCP can greatly improve the quality of life of patients. However, effects of E-CFCP are unclear in renal. The aim of this study is to clarify the effects of E-CFCP in the kidney, especially organic acid transporter（Organic anion transporters：OATs, Organic cation transporter：OCT）. We conducted cell viability studies using mouse-derived renal cortical cells (S2, CCD, cTAL) and uptake studies using radioisotopes to determine the effects of E-CFCP on the kidneys. In cell viability studies, E-CFCP has no cytotoxicity in all cell lines. We also examined the effect of drugs at high concentration using S2 cells. E-CFCP has no cytotoxicity even at high concentrations. In the substrate uptake assay, there was no inhibition of substrate uptake by E-CFCP, the transporter is not involved in the intracellular transport of E-CFCP and is unlikely to cause cytotoxicity. In conclusion, E-CFCP, a novel HBV antiviral drug, is unlikely to cause renal damage. It may be a novel great candidate drug of HBV for patients with drug-resistant HBV.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79374749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_4-b-s44-2
Yasuhiko Izumi
{"title":"Exploration of Nrf2-ARE pathway activators for the prevention and treatment of diseases","authors":"Yasuhiko Izumi","doi":"10.1254/jpssuppl.96.0_4-b-s44-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s44-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79430705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-cl
A. Miyata
{"title":"From Discovery to Clinical application of PACAP","authors":"A. Miyata","doi":"10.1254/jpssuppl.95.0_1-cl","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-cl","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81809819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-sl06
Kazuhide Inoue
{"title":"Pharmacological action of ATP receptors and current status of related drug development","authors":"Kazuhide Inoue","doi":"10.1254/jpssuppl.95.0_2-sl06","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-sl06","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81872063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_1-b-p-075
Takeya Sato, N. Toda, Masaki Saito, Masanori Yamauchi, Takaaki Abe
{"title":"Doxorubicin did not affect the lysosomal acidification","authors":"Takeya Sato, N. Toda, Masaki Saito, Masanori Yamauchi, Takaaki Abe","doi":"10.1254/jpssuppl.96.0_1-b-p-075","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-p-075","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84229544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-o03-3
L. Gen, Y. Ogura, Y. Ujihara, Fubito Toyama, Keitaro Hayashi, T. Fujita
{"title":"Na+/Ca2+ exchanger type 1 functions as a “brake” of hyperactivation in hamster sperm.","authors":"L. Gen, Y. Ogura, Y. Ujihara, Fubito Toyama, Keitaro Hayashi, T. Fujita","doi":"10.1254/jpssuppl.96.0_2-b-o03-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-o03-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"468 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84461876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_1-b-s08-2
Kazuki Yoshida, Masa-aki Ito, I. Matsuoka
{"title":"Purinergic regulation of mast cell function and allergic response via ionotropic P2X4 receptors","authors":"Kazuki Yoshida, Masa-aki Ito, I. Matsuoka","doi":"10.1254/jpssuppl.96.0_1-b-s08-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-s08-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84507687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_1-b-p-076
Asano Satoshi, Y. Ago, T. Kanematsu
{"title":"Phospholipase C like protein PRIP1 PH-domain-containing liposomes enhance apoptotic cell death in cisplatin resistant breast cancer cells","authors":"Asano Satoshi, Y. Ago, T. Kanematsu","doi":"10.1254/jpssuppl.96.0_1-b-p-076","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-p-076","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84529992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_1-b-ss05-1
Hamaguchi Norie, N. Adachi, T. Moriya, M. Kawasaki, Kenji Yasuda, T. Senda, Satoshi Oagasawara, T. Murata
{"title":"Three-dimensional structural analysis of pharmacokinetics-related membrane protein P-glycoprotein using cryo-electron microscopy","authors":"Hamaguchi Norie, N. Adachi, T. Moriya, M. Kawasaki, Kenji Yasuda, T. Senda, Satoshi Oagasawara, T. Murata","doi":"10.1254/jpssuppl.96.0_1-b-ss05-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-ss05-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85011407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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