Pub Date : 2023-01-01DOI: 10.1254/jpssuppl.95.0_1-sl01
Masashi Yanagisawa
{"title":"Deciphering the mystery of sleep: toward the molecular substrate for \"sleepiness\"","authors":"Masashi Yanagisawa","doi":"10.1254/jpssuppl.95.0_1-sl01","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-sl01","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74561471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.1254/JPSSUPPL.92.0_3-CS4-1
K. Tsunoyama
(AI). AI simulated in programmed to mimic human brain behavior learning, reasoning and problem Many computer algorithms to previous waves, this latest wave of AI by deep learning algorithm which is inspired by how human brain processes information through interaction of neurons. The first simplified mathematical model of neuron, the formal neuron, 1943. In this model, a neuron receives a set of binary inputs from other neurons, multiplies each input with the weight (i.e. the strength of synapse), and activates if the sum of these weighted inputs is greater than a threshold. More than 70 years have passed since this simple model was proposed and we are now seeing many examples where AI beats humans. In this symposium, we have speakers from two pairs of pharmaceutical and IT companies that have recently announced big partnership for AI technology, and they will present their recent development and application of AI, and their future prospects. I hope we can learn many cases of applications of AI to biology, pharmacology, drug discovery, and pharmaceutical business.
{"title":"AI and drug discovery","authors":"K. Tsunoyama","doi":"10.1254/JPSSUPPL.92.0_3-CS4-1","DOIUrl":"https://doi.org/10.1254/JPSSUPPL.92.0_3-CS4-1","url":null,"abstract":"(AI). AI simulated in programmed to mimic human brain behavior learning, reasoning and problem Many computer algorithms to previous waves, this latest wave of AI by deep learning algorithm which is inspired by how human brain processes information through interaction of neurons. The first simplified mathematical model of neuron, the formal neuron, 1943. In this model, a neuron receives a set of binary inputs from other neurons, multiplies each input with the weight (i.e. the strength of synapse), and activates if the sum of these weighted inputs is greater than a threshold. More than 70 years have passed since this simple model was proposed and we are now seeing many examples where AI beats humans. In this symposium, we have speakers from two pairs of pharmaceutical and IT companies that have recently announced big partnership for AI technology, and they will present their recent development and application of AI, and their future prospects. I hope we can learn many cases of applications of AI to biology, pharmacology, drug discovery, and pharmaceutical business.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80430153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.1254/jpssuppl.95.0_2-p-119
K. Matsuura, K. Kadoyama
Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of normal aging and the more serious decline of dementia. Since MCI may increase risk of later developing dementia caused by Alzheimer's disease (AD) or other neurological conditions, it is important to detect and treat MCI early in order to prevent dementia. Causal discovery, which can visualize causal relationships (cause and effect) among data, has recently been attracting attention. One of its algorithms, the Linear Non-Gaussian Acyclic Model (LiNGAM), can extract causal relationships among variables from statistical data only, using probability distributions of variables that are generally non-Gaussian. In this study, we used LiNGAM to analyze gene expression data in the hippocampus of healthy subjects and of MCI patients, and also the Mini-Mental State Examination (MMSE) scores, which are used to assess cognitive decline. We found that cell adhesion molecule 4 (CADM4) gene regulates cognitive processes that are measured in terms of MMSE scores. Our results revealed a causal relationship between gene expression changes and MMSE scores, and allowed us to identify the genes responsible for cognitive decline..
{"title":"Elucidation of the mechanism of cognitive decline in mild cognitive impairment (MCI) using causal discovery","authors":"K. Matsuura, K. Kadoyama","doi":"10.1254/jpssuppl.95.0_2-p-119","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-119","url":null,"abstract":"Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of normal aging and the more serious decline of dementia. Since MCI may increase risk of later developing dementia caused by Alzheimer's disease (AD) or other neurological conditions, it is important to detect and treat MCI early in order to prevent dementia. Causal discovery, which can visualize causal relationships (cause and effect) among data, has recently been attracting attention. One of its algorithms, the Linear Non-Gaussian Acyclic Model (LiNGAM), can extract causal relationships among variables from statistical data only, using probability distributions of variables that are generally non-Gaussian. In this study, we used LiNGAM to analyze gene expression data in the hippocampus of healthy subjects and of MCI patients, and also the Mini-Mental State Examination (MMSE) scores, which are used to assess cognitive decline. We found that cell adhesion molecule 4 (CADM4) gene regulates cognitive processes that are measured in terms of MMSE scores. Our results revealed a causal relationship between gene expression changes and MMSE scores, and allowed us to identify the genes responsible for cognitive decline..","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77737297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-p-025
Mari Sueyoshi, Masaki Okawa, Mayuko Takeda, Teruki Matuhara, Kaneyasu Nishimura, S. Shimohama, K. Takata
{"title":"Functional regulation targeting nicotinic acetylcholine receptors using iPS cell-derived microglia","authors":"Mari Sueyoshi, Masaki Okawa, Mayuko Takeda, Teruki Matuhara, Kaneyasu Nishimura, S. Shimohama, K. Takata","doi":"10.1254/jpssuppl.95.0_1-p-025","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-p-025","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73666444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Our pre-clinical support for neurotransmitter evaluation in the brain of rodents using a microdialysis method","authors":"Kohei Araki, Keita Saito, Kotaro Suzuki, Toru Nonomura, Noriyuki Yamazaki","doi":"10.1254/jpssuppl.96.0_2-b-p-158","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-p-158","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"307 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73750941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_yia03-3
H. Kawagishi, R. Ramadhiani, Takuro Tomita-Numaga, Tsutomu Nakada, N. Emoto, M. Yamada
{"title":"β-arrestin-biased AT1R agonist improves health- and lifespan in mice with congenital dilated cardiomyopathy","authors":"H. Kawagishi, R. Ramadhiani, Takuro Tomita-Numaga, Tsutomu Nakada, N. Emoto, M. Yamada","doi":"10.1254/jpssuppl.96.0_yia03-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_yia03-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73805620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-p-166
Yuki Fujiwara, Midori Hoshizaki, Ryota Nukiwa, Mara Anais Llamas Covarrubias, Y. Imai
{"title":"Analysis of the pathogenesis of ICU acquired weakness (ICU-AW) in mice","authors":"Yuki Fujiwara, Midori Hoshizaki, Ryota Nukiwa, Mara Anais Llamas Covarrubias, Y. Imai","doi":"10.1254/jpssuppl.95.0_2-p-166","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-166","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74057735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-ss11-3
Hayato Shimora, Yukino Nagatani, Tenta Haguchi, Itomi Takamori, Masaya Matsuda, K. Kitatani, T. Nabe
{"title":"Roles of CCR5 in development of fibrosis in severe asthma","authors":"Hayato Shimora, Yukino Nagatani, Tenta Haguchi, Itomi Takamori, Masaya Matsuda, K. Kitatani, T. Nabe","doi":"10.1254/jpssuppl.96.0_2-b-ss11-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-ss11-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1412 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74151467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_3-p-193
T. Iwao, F. Takata, Junichi Matsumoto, S. Dohgu
{"title":"Brain pericytes promote brain endothelial DHA uptake through inducing membrane expression of the transporter MFSD2A","authors":"T. Iwao, F. Takata, Junichi Matsumoto, S. Dohgu","doi":"10.1254/jpssuppl.95.0_3-p-193","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-p-193","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74271465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-s03-3
Shuji Mori, Takao Toyomura, Masahiro Watanabe
{"title":"Regulation of inflammatory response based on DAMPs interaction","authors":"Shuji Mori, Takao Toyomura, Masahiro Watanabe","doi":"10.1254/jpssuppl.95.0_1-s03-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-s03-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75868965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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