Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-s28-3
Terao Kimio
How quickly reach the goal / establish the platform of artificial intelligence (AI) for drug development is one of the biggest issue for most of pharmaceutical company. Model informed drug development (MIDD) is applied across the drug development phase, and biology / physiology based sciences. One of the key expected outcomes by MIDD is to estimate 3 view points of RIGHT which are "RIGHT dose", "RIGHT patients", and "RIGHT timing". To obtain three RIGHT, it is required to demonstrate drug exposure, drug penetration, pharmacodynamic biomarker response, and clinical outcomes. Quantitative system pharmacology (QSP) model is one the tool find these "RIGHT" and is give us the hypothetical resolution against the research/clinical questions. Integrated into wet experimental data, genetic analysis, drug binding, metabolism, polymorphisms, biological pathways. Accurate computational power is required to establish the appropriate quality of QSP model, therefore abilities of AI is required. To implementation of AI to resolve the dedicated model, it is expected to accelerated the speed of drug development and QSP model primed to change the landscape of drug development. Company-Organized Symposium
{"title":"Cutting edge approach using Modeling and Simulation, AI in drug development -How to boost the clinical drug development-","authors":"Terao Kimio","doi":"10.1254/jpssuppl.95.0_2-s28-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-s28-3","url":null,"abstract":"How quickly reach the goal / establish the platform of artificial intelligence (AI) for drug development is one of the biggest issue for most of pharmaceutical company. Model informed drug development (MIDD) is applied across the drug development phase, and biology / physiology based sciences. One of the key expected outcomes by MIDD is to estimate 3 view points of RIGHT which are \"RIGHT dose\", \"RIGHT patients\", and \"RIGHT timing\". To obtain three RIGHT, it is required to demonstrate drug exposure, drug penetration, pharmacodynamic biomarker response, and clinical outcomes. Quantitative system pharmacology (QSP) model is one the tool find these \"RIGHT\" and is give us the hypothetical resolution against the research/clinical questions. Integrated into wet experimental data, genetic analysis, drug binding, metabolism, polymorphisms, biological pathways. Accurate computational power is required to establish the appropriate quality of QSP model, therefore abilities of AI is required. To implementation of AI to resolve the dedicated model, it is expected to accelerated the speed of drug development and QSP model primed to change the landscape of drug development. Company-Organized Symposium","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77677792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-p-090
Tomoya Kawamoto, Akito Nakao, Barneo José López, Y. Mori
{"title":"The role of TRPA1 in hypoxic response of the carotid body","authors":"Tomoya Kawamoto, Akito Nakao, Barneo José López, Y. Mori","doi":"10.1254/jpssuppl.95.0_1-p-090","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-p-090","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77860420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-s17-1
A. Ito
{"title":"Development of therapeutic drugs for sickle cell disease targeting a histone methyltransferase","authors":"A. Ito","doi":"10.1254/jpssuppl.96.0_2-b-s17-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s17-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"25 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77869448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-p-099
Y. Aono, Koji Saito, T. Saigusa
{"title":"Intragingival application of Porphyromonas gingivalis-derived lipopolysaccharide induces an increase in plasma TNF-α levels in anaesthetised rats","authors":"Y. Aono, Koji Saito, T. Saigusa","doi":"10.1254/jpssuppl.96.0_2-b-p-099","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-p-099","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"141 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77893489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-ss-12
Tajika Rei, D. Masukawa, H. Uchimura, Y. Goshima
{"title":"The L-DOPA receptor GPR143 in the indirect pathways regulates an anxiety-like behavior in mice","authors":"Tajika Rei, D. Masukawa, H. Uchimura, Y. Goshima","doi":"10.1254/jpssuppl.95.0_1-ss-12","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-12","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79792859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_3-p-263
Keitaro Satoh, Yuta Ohno, Haruna Nagase, M. Kashimata, Kazunori Adachi
{"title":"Involvement of alteration of CD36 expression on pilocarpine-induced salivation in mouse parotid gland","authors":"Keitaro Satoh, Yuta Ohno, Haruna Nagase, M. Kashimata, Kazunori Adachi","doi":"10.1254/jpssuppl.95.0_3-p-263","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-p-263","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79797889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_yia07-1
Kaho Nakamura
{"title":"Development and application of a novel probe that realize the imaging analysis of oxytocin dynamics in brain tissue","authors":"Kaho Nakamura","doi":"10.1254/jpssuppl.96.0_yia07-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_yia07-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80035443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-p-171
Goto Momo, Kazuhisa Kishi, Yoshiharu Tsuru, M. Hori
{"title":"Noninvasive monitoring of muscle atrophy and bone metabolic disorder using Dual energy X-ray absorptiometry (DXA) in diabetes mellitus model mouse","authors":"Goto Momo, Kazuhisa Kishi, Yoshiharu Tsuru, M. Hori","doi":"10.1254/jpssuppl.95.0_2-p-171","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-171","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80209936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-p-173
Utsumi Daichi, Masamitsu N. Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Y. Kawaoka, K. Kuba, Y. Yasutomi
COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequence. Vaccine is just not enough to suppress to this pandemic, and it is desired to develop the prophylactic and therapeutic agents for preventing the spread of infection and severity. Therefore, it is extremely important to propose therapeutic strategies by using pathological models. In this study, we established an animal model with highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG-promoter-driven human angiotensin-converting enzyme 2 transgenic (CAG-hACE2) mice that more than 15 copies of hACE2 genes were tandemly integrated into the mouse genome. The CAG-hACE2 mice showed several severe symptoms of SARS-CoV-2 infection, with definitive weight loss and subsequent death. Acute pneumonia with elevated cytokine and chemokine levels was observed at an early stage of infection in CAG-hACE2 mice infected with SARS-CoV-2. In the developed model, administration of remdesivir, which is antiviral agent, or injection of plasma from immunized mice prevented body weight loss and lethality due to infection with SARS-CoV-2. These results indicated that a highly susceptible model of SARS-CoV-2 infection in CAG-hACE2 mice via the intratracheal tract is suitable for evaluating antibody therapeutics and medicines.
{"title":"Establishment of SARS-CoV-2 respiratory tract infection model in CAG promoter-driven hACE2 transgenic mice","authors":"Utsumi Daichi, Masamitsu N. Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Y. Kawaoka, K. Kuba, Y. Yasutomi","doi":"10.1254/jpssuppl.95.0_2-p-173","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-173","url":null,"abstract":"COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequence. Vaccine is just not enough to suppress to this pandemic, and it is desired to develop the prophylactic and therapeutic agents for preventing the spread of infection and severity. Therefore, it is extremely important to propose therapeutic strategies by using pathological models. In this study, we established an animal model with highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG-promoter-driven human angiotensin-converting enzyme 2 transgenic (CAG-hACE2) mice that more than 15 copies of hACE2 genes were tandemly integrated into the mouse genome. The CAG-hACE2 mice showed several severe symptoms of SARS-CoV-2 infection, with definitive weight loss and subsequent death. Acute pneumonia with elevated cytokine and chemokine levels was observed at an early stage of infection in CAG-hACE2 mice infected with SARS-CoV-2. In the developed model, administration of remdesivir, which is antiviral agent, or injection of plasma from immunized mice prevented body weight loss and lethality due to infection with SARS-CoV-2. These results indicated that a highly susceptible model of SARS-CoV-2 infection in CAG-hACE2 mice via the intratracheal tract is suitable for evaluating antibody therapeutics and medicines.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_yia01-5
D. Tone, K. Ode, Qianhui Zhang, Hiroki R Ueda
{"title":"Multistep regulation of mammalian sleep by phosphorylation states of CaMKII","authors":"D. Tone, K. Ode, Qianhui Zhang, Hiroki R Ueda","doi":"10.1254/jpssuppl.96.0_yia01-5","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_yia01-5","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79138006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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