Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_2-p-159
Hashizume Hiroki, Hatsune Motonari, Yoki Nakamura, K. Hisaoka-Nakashima, N. Morioka
{"title":"Inhibitory effect of REV-ERB agonist on inflammatory responses in primary cultured rat chondrocytes","authors":"Hashizume Hiroki, Hatsune Motonari, Yoki Nakamura, K. Hisaoka-Nakashima, N. Morioka","doi":"10.1254/jpssuppl.95.0_2-p-159","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-159","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74504126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-hs01-4
Yoshinori Mikami, Fumiki Iwase, T. Tomida, Daisuke Ohshima, S. Adachi-Akahane
{"title":"Upregulation of neuregulin-1 in the ventricle of diabetic cardiomyopathy model mice and its functional significance","authors":"Yoshinori Mikami, Fumiki Iwase, T. Tomida, Daisuke Ohshima, S. Adachi-Akahane","doi":"10.1254/jpssuppl.96.0_3-b-hs01-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-hs01-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74530793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_4-b-s35-1
N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, M. Nishibori
{"title":"Chronic pain model: Effects of intranasal administration of antibody preparation on inflammatory response, pain, and accompanying behavioral abnormalities","authors":"N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, M. Nishibori","doi":"10.1254/jpssuppl.96.0_4-b-s35-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s35-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74632659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_4-b-p-315
M. Ouchi, Asuka Morita, Keitaro Satoh, N. Anzai, T. Fujita
{"title":"Evaluation of insulin secretion by organ bath of isolated pancreases","authors":"M. Ouchi, Asuka Morita, Keitaro Satoh, N. Anzai, T. Fujita","doi":"10.1254/jpssuppl.96.0_4-b-p-315","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-p-315","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74637826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_2-b-s17-4
Suzuki Takayoshi
{"title":"Drug Development and Chemical Biology Targeting Epigenetics","authors":"Suzuki Takayoshi","doi":"10.1254/jpssuppl.96.0_2-b-s17-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s17-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74919732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-p-312
H. Mizuguchi, Aurpita Shaha, R. Islam, Y. Kitamura, N. Takeda, H. Fukui
{"title":"Identification of betuletol from Brazilian Green Propolis that suppresses IL-33 gene expression in Swiss3T3 cells","authors":"H. Mizuguchi, Aurpita Shaha, R. Islam, Y. Kitamura, N. Takeda, H. Fukui","doi":"10.1254/jpssuppl.96.0_3-b-p-312","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-312","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72977880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_yia06-3
T. Nishinaka, O. Hatipoglu, H. Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, M. Nishibori, Hideo Takahashi
{"title":"Regulation of STING signal by advanced glycation end products","authors":"T. Nishinaka, O. Hatipoglu, H. Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, M. Nishibori, Hideo Takahashi","doi":"10.1254/jpssuppl.96.0_yia06-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_yia06-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72992767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_3-s36-2
Satoh Takashi
Macrophages have been discovered more than 100 years ago. Recent studies indicated that monocytes and macrophages can be categorized into several distinct phenotypes and their respective differentiation mechanisms are known. We also reported that the Jmjd3 is critical for the macrophage subtype activated by allergic stimuli (Nat. Immunol. 2010) and that the tissue resident macrophage subtype in adipose tissue, which is controlled by Trib1, is responsible for maintaining homeostasis of peripheral tissues such as adipocyte (Nature. 2013). Thus, it is considered that various macrophage/monocyte subtypes corresponding to certain disorders were existed in our body. Furthermore, in order to investigate the relationship between macrophage subtype and disease, we focused on fibrosis as the next target disease. Its pathogenesis is poorly understood, and there are few effective therapies. Previously we found that a new macrophage/monocyte subtype, which their markers are monocyte and share granulocyte characteristics, involved in development of fibrosis was accumulated in the affected area in the lungs at the beginning of fibrosis. We termed the monocyte/ macrophage subtype segregated-nucleus-containing atypical monocytes (SatM) (Nature. 2017). Towards understanding the mechanism of fibrosis onset, we next focused on investigation of non-haematopoietic cells involved in activation of immune cell such as SatM during fibrotic phase.
{"title":"Disorder specific macrophage subtype -Towards understanding the mechanism of fibrosis onset-","authors":"Satoh Takashi","doi":"10.1254/jpssuppl.95.0_3-s36-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-s36-2","url":null,"abstract":"Macrophages have been discovered more than 100 years ago. Recent studies indicated that monocytes and macrophages can be categorized into several distinct phenotypes and their respective differentiation mechanisms are known. We also reported that the Jmjd3 is critical for the macrophage subtype activated by allergic stimuli (Nat. Immunol. 2010) and that the tissue resident macrophage subtype in adipose tissue, which is controlled by Trib1, is responsible for maintaining homeostasis of peripheral tissues such as adipocyte (Nature. 2013). Thus, it is considered that various macrophage/monocyte subtypes corresponding to certain disorders were existed in our body. Furthermore, in order to investigate the relationship between macrophage subtype and disease, we focused on fibrosis as the next target disease. Its pathogenesis is poorly understood, and there are few effective therapies. Previously we found that a new macrophage/monocyte subtype, which their markers are monocyte and share granulocyte characteristics, involved in development of fibrosis was accumulated in the affected area in the lungs at the beginning of fibrosis. We termed the monocyte/ macrophage subtype segregated-nucleus-containing atypical monocytes (SatM) (Nature. 2017). Towards understanding the mechanism of fibrosis onset, we next focused on investigation of non-haematopoietic cells involved in activation of immune cell such as SatM during fibrotic phase.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72995767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.96.0_3-b-s30-3
Kawai Takayuki
{"title":"Development of an Ultra-sensitive Analysis Method for the Profiling of Trace Brain Molecules","authors":"Kawai Takayuki","doi":"10.1254/jpssuppl.96.0_3-b-s30-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-s30-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73049098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1254/jpssuppl.95.0_1-ss-64
Mao Kaneki, Miyu Takahashi, Jumpei Uchiyama, Tetsuya Ano, T. Fukuyama
{"title":"Potential therapeutic effects of ozone water on pyoderma and atopic dermatitis in dogs","authors":"Mao Kaneki, Miyu Takahashi, Jumpei Uchiyama, Tetsuya Ano, T. Fukuyama","doi":"10.1254/jpssuppl.95.0_1-ss-64","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-64","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73238908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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