首页 > 最新文献

Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献

英文 中文
Inhibitory effect of REV-ERB agonist on inflammatory responses in primary cultured rat chondrocytes REV-ERB激动剂对原代培养大鼠软骨细胞炎症反应的抑制作用
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-p-159
Hashizume Hiroki, Hatsune Motonari, Yoki Nakamura, K. Hisaoka-Nakashima, N. Morioka
{"title":"Inhibitory effect of REV-ERB agonist on inflammatory responses in primary cultured rat chondrocytes","authors":"Hashizume Hiroki, Hatsune Motonari, Yoki Nakamura, K. Hisaoka-Nakashima, N. Morioka","doi":"10.1254/jpssuppl.95.0_2-p-159","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-159","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74504126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of neuregulin-1 in the ventricle of diabetic cardiomyopathy model mice and its functional significance 糖尿病心肌病模型小鼠脑室神经调节蛋白1的上调及其功能意义
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_3-b-hs01-4
Yoshinori Mikami, Fumiki Iwase, T. Tomida, Daisuke Ohshima, S. Adachi-Akahane
{"title":"Upregulation of neuregulin-1 in the ventricle of diabetic cardiomyopathy model mice and its functional significance","authors":"Yoshinori Mikami, Fumiki Iwase, T. Tomida, Daisuke Ohshima, S. Adachi-Akahane","doi":"10.1254/jpssuppl.96.0_3-b-hs01-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-hs01-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74530793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic pain model: Effects of intranasal administration of antibody preparation on inflammatory response, pain, and accompanying behavioral abnormalities 慢性疼痛模型:鼻内注射抗体制剂对炎症反应、疼痛和伴随的行为异常的影响
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-s35-1
N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, M. Nishibori
{"title":"Chronic pain model: Effects of intranasal administration of antibody preparation on inflammatory response, pain, and accompanying behavioral abnormalities","authors":"N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, M. Nishibori","doi":"10.1254/jpssuppl.96.0_4-b-s35-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s35-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74632659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of insulin secretion by organ bath of isolated pancreases 离体胰腺器官浴对胰岛素分泌的评价
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-p-315
M. Ouchi, Asuka Morita, Keitaro Satoh, N. Anzai, T. Fujita
{"title":"Evaluation of insulin secretion by organ bath of isolated pancreases","authors":"M. Ouchi, Asuka Morita, Keitaro Satoh, N. Anzai, T. Fujita","doi":"10.1254/jpssuppl.96.0_4-b-p-315","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-p-315","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74637826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Development and Chemical Biology Targeting Epigenetics 靶向表观遗传学的药物开发和化学生物学
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-s17-4
Suzuki Takayoshi
{"title":"Drug Development and Chemical Biology Targeting Epigenetics","authors":"Suzuki Takayoshi","doi":"10.1254/jpssuppl.96.0_2-b-s17-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s17-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74919732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of betuletol from Brazilian Green Propolis that suppresses IL-33 gene expression in Swiss3T3 cells 抑制Swiss3T3细胞IL-33基因表达的巴西绿蜂胶中甜菜醇的鉴定
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_3-b-p-312
H. Mizuguchi, Aurpita Shaha, R. Islam, Y. Kitamura, N. Takeda, H. Fukui
{"title":"Identification of betuletol from Brazilian Green Propolis that suppresses IL-33 gene expression in Swiss3T3 cells","authors":"H. Mizuguchi, Aurpita Shaha, R. Islam, Y. Kitamura, N. Takeda, H. Fukui","doi":"10.1254/jpssuppl.96.0_3-b-p-312","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-312","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72977880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of STING signal by advanced glycation end products 晚期糖基化终产物对STING信号的调控
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_yia06-3
T. Nishinaka, O. Hatipoglu, H. Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, M. Nishibori, Hideo Takahashi
{"title":"Regulation of STING signal by advanced glycation end products","authors":"T. Nishinaka, O. Hatipoglu, H. Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, M. Nishibori, Hideo Takahashi","doi":"10.1254/jpssuppl.96.0_yia06-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_yia06-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72992767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disorder specific macrophage subtype -Towards understanding the mechanism of fibrosis onset- 疾病特异性巨噬细胞亚型-了解纤维化发病机制-
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-s36-2
Satoh Takashi
Macrophages have been discovered more than 100 years ago. Recent studies indicated that monocytes and macrophages can be categorized into several distinct phenotypes and their respective differentiation mechanisms are known. We also reported that the Jmjd3 is critical for the macrophage subtype activated by allergic stimuli (Nat. Immunol. 2010) and that the tissue resident macrophage subtype in adipose tissue, which is controlled by Trib1, is responsible for maintaining homeostasis of peripheral tissues such as adipocyte (Nature. 2013). Thus, it is considered that various macrophage/monocyte subtypes corresponding to certain disorders were existed in our body. Furthermore, in order to investigate the relationship between macrophage subtype and disease, we focused on fibrosis as the next target disease. Its pathogenesis is poorly understood, and there are few effective therapies. Previously we found that a new macrophage/monocyte subtype, which their markers are monocyte and share granulocyte characteristics, involved in development of fibrosis was accumulated in the affected area in the lungs at the beginning of fibrosis. We termed the monocyte/ macrophage subtype segregated-nucleus-containing atypical monocytes (SatM) (Nature. 2017). Towards understanding the mechanism of fibrosis onset, we next focused on investigation of non-haematopoietic cells involved in activation of immune cell such as SatM during fibrotic phase.
巨噬细胞在100多年前就被发现了。最近的研究表明,单核细胞和巨噬细胞可以分为几种不同的表型,它们各自的分化机制是已知的。我们还报道了Jmjd3对过敏刺激激活的巨噬细胞亚型至关重要(Nat. immuno1 . 2010),脂肪组织中由Trib1控制的组织常驻巨噬细胞亚型负责维持脂肪细胞等外周组织的稳态(Nature. 2013)。因此,我们认为我们体内存在着与某些疾病相对应的各种巨噬细胞/单核细胞亚型。此外,为了研究巨噬细胞亚型与疾病之间的关系,我们将纤维化作为下一个目标疾病。其发病机制尚不清楚,有效的治疗方法也很少。先前我们发现,一种新的巨噬细胞/单核细胞亚型,其标记为单核细胞并具有粒细胞特征,参与纤维化的发展,在纤维化开始时积聚在肺部受影响区域。我们将单核细胞/巨噬细胞亚型命名为含分离核的非典型单核细胞(SatM) (Nature. 2017)。为了了解纤维化发生的机制,我们接下来将重点研究非造血细胞在纤维化期参与免疫细胞(如SatM)的激活。
{"title":"Disorder specific macrophage subtype -Towards understanding the mechanism of fibrosis onset-","authors":"Satoh Takashi","doi":"10.1254/jpssuppl.95.0_3-s36-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-s36-2","url":null,"abstract":"Macrophages have been discovered more than 100 years ago. Recent studies indicated that monocytes and macrophages can be categorized into several distinct phenotypes and their respective differentiation mechanisms are known. We also reported that the Jmjd3 is critical for the macrophage subtype activated by allergic stimuli (Nat. Immunol. 2010) and that the tissue resident macrophage subtype in adipose tissue, which is controlled by Trib1, is responsible for maintaining homeostasis of peripheral tissues such as adipocyte (Nature. 2013). Thus, it is considered that various macrophage/monocyte subtypes corresponding to certain disorders were existed in our body. Furthermore, in order to investigate the relationship between macrophage subtype and disease, we focused on fibrosis as the next target disease. Its pathogenesis is poorly understood, and there are few effective therapies. Previously we found that a new macrophage/monocyte subtype, which their markers are monocyte and share granulocyte characteristics, involved in development of fibrosis was accumulated in the affected area in the lungs at the beginning of fibrosis. We termed the monocyte/ macrophage subtype segregated-nucleus-containing atypical monocytes (SatM) (Nature. 2017). Towards understanding the mechanism of fibrosis onset, we next focused on investigation of non-haematopoietic cells involved in activation of immune cell such as SatM during fibrotic phase.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72995767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an Ultra-sensitive Analysis Method for the Profiling of Trace Brain Molecules 一种用于痕量脑分子分析的超灵敏分析方法的发展
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_3-b-s30-3
Kawai Takayuki
{"title":"Development of an Ultra-sensitive Analysis Method for the Profiling of Trace Brain Molecules","authors":"Kawai Takayuki","doi":"10.1254/jpssuppl.96.0_3-b-s30-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-s30-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73049098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential therapeutic effects of ozone water on pyoderma and atopic dermatitis in dogs 臭氧水对狗脓皮病和特应性皮炎的潜在治疗作用
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-ss-64
Mao Kaneki, Miyu Takahashi, Jumpei Uchiyama, Tetsuya Ano, T. Fukuyama
{"title":"Potential therapeutic effects of ozone water on pyoderma and atopic dermatitis in dogs","authors":"Mao Kaneki, Miyu Takahashi, Jumpei Uchiyama, Tetsuya Ano, T. Fukuyama","doi":"10.1254/jpssuppl.95.0_1-ss-64","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-64","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73238908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Proceedings for Annual Meeting of The Japanese Pharmacological Society
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1