首页 > 最新文献

Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献

英文 中文
Epigenetic regulation of myeloid cell differentiation 髓细胞分化的表观遗传调控
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-s36-3
Kurotaki Daisuke
We have been studying the mechanism of myeloid cell development from the viewpoint of chromatin regulation by transcription factors. The transcription factor IRF8 is essential for the development of monocytes and dendritic cells (DCs), whereas it inhibits neutrophilic differentiation. We have demonstrated that IRF8 establishes enhancer landscapes in myeloid progenitors to epigenetically prime these cells to differentiate into monocytes or DCs. Recently, we focus on high-order chromatin structure during DC development. Our Hi-C data revealed that DC-specific active compartments are gradually established throughout the course of differentiation, while most of the topologically associating domains (TADs) specific for the DC lineage are formed with slower kinetics. We also found that the activation of DC-specific enhancers proceeds the compartment switch and subsequent gene expression. In addition, our data suggest that IRF8 is required for many of the DC-specific changes from compartment B to A. Collectively, myeloid cell gene expression patterns are epigenetically regulated by key transcription factors such as IRF8 via enhancer establishment and chromatin structure reorganization. Symposium 36
我们一直从转录因子调控染色质的角度研究髓细胞发育的机制。转录因子IRF8对单核细胞和树突状细胞(DCs)的发育至关重要,而它抑制中性粒细胞分化。我们已经证明,IRF8在髓系祖细胞中建立了增强子景观,以表观遗传方式诱导这些细胞分化为单核细胞或dc。近年来,我们主要关注DC发育过程中的高阶染色质结构。我们的Hi-C数据显示,DC特异性活性区室在整个分化过程中逐渐建立,而DC谱系特异性的大多数拓扑相关结构域(TADs)是在较慢的动力学过程中形成的。我们还发现dc特异性增强子的激活促进了隔室开关和随后的基因表达。此外,我们的数据表明,从B室到a室的许多dc特异性变化都需要IRF8。总的来说,髓细胞基因表达模式通过增强子的建立和染色质结构重组受到关键转录因子(如IRF8)的表观遗传调控。研讨会36
{"title":"Epigenetic regulation of myeloid cell differentiation","authors":"Kurotaki Daisuke","doi":"10.1254/jpssuppl.95.0_3-s36-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-s36-3","url":null,"abstract":"We have been studying the mechanism of myeloid cell development from the viewpoint of chromatin regulation by transcription factors. The transcription factor IRF8 is essential for the development of monocytes and dendritic cells (DCs), whereas it inhibits neutrophilic differentiation. We have demonstrated that IRF8 establishes enhancer landscapes in myeloid progenitors to epigenetically prime these cells to differentiate into monocytes or DCs. Recently, we focus on high-order chromatin structure during DC development. Our Hi-C data revealed that DC-specific active compartments are gradually established throughout the course of differentiation, while most of the topologically associating domains (TADs) specific for the DC lineage are formed with slower kinetics. We also found that the activation of DC-specific enhancers proceeds the compartment switch and subsequent gene expression. In addition, our data suggest that IRF8 is required for many of the DC-specific changes from compartment B to A. Collectively, myeloid cell gene expression patterns are epigenetically regulated by key transcription factors such as IRF8 via enhancer establishment and chromatin structure reorganization. Symposium 36","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75375543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synapse formation and remodeling visualized in physiological and pathological states 突触的形成和重塑在生理和病理状态下可见
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-sl03
S. Okabe
The development of neuronal circuits in vivo depends on precise regulation of synapse formation, elimination, and remodeling. In vivo two-photon imaging confirmed the presence of two phases of synapse dynamics in the postnatal mouse cortex. In the first phase (until postnatal 20 days), synapse turnover is maintained to be high, while in the second phase (after three weeks postnatal), synapse dynamics are highly suppressed, leading to the maturation of the cortical neural network. The transition in synapse dynamics may underlie the pathophysiology of neurodevelopmental disorders and psychiatric diseases, but their precise mechanisms have not yet been clarified. Our laboratory has focused on (1) the diverse mechanisms in neural circuits and synapse formation, (2) the structure-function relationship in dynamic synaptic changes, and (3) the relationship between brain diseases and synaptic dysfunction. In particular, we have recently developed new tools for studying neural circuits, such as quantitative methods for analyzing the nano-structure of spine synapses and methods for measuring the molecular dynamics inside spines. Furthermore, we are applying these tools to the study of brain pathology. In this talk, I will introduce these researches and discuss the validity and prospects of understanding the pathogenesis of psychiatric disorders as synaptic dysfunction.
体内神经元回路的发育依赖于突触形成、消除和重塑的精确调控。体内双光子成像证实了出生后小鼠皮层突触动力学的两个阶段的存在。在第一阶段(直到出生后20天),突触更新维持在较高水平,而在第二阶段(出生后3周),突触动力学被高度抑制,导致皮质神经网络成熟。突触动力学的转变可能是神经发育障碍和精神疾病病理生理学的基础,但其确切机制尚未阐明。我们的实验室重点研究(1)神经回路和突触形成的多种机制,(2)动态突触变化的结构-功能关系,(3)脑部疾病与突触功能障碍的关系。特别是,我们最近开发了研究神经回路的新工具,如用于分析脊柱突触纳米结构的定量方法和用于测量脊柱内部分子动力学的方法。此外,我们正在将这些工具应用于脑病理学的研究。在这次演讲中,我将介绍这些研究,并讨论将精神疾病的发病机制理解为突触功能障碍的有效性和前景。
{"title":"Synapse formation and remodeling visualized in physiological and pathological states","authors":"S. Okabe","doi":"10.1254/jpssuppl.95.0_1-sl03","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-sl03","url":null,"abstract":"The development of neuronal circuits in vivo depends on precise regulation of synapse formation, elimination, and remodeling. In vivo two-photon imaging confirmed the presence of two phases of synapse dynamics in the postnatal mouse cortex. In the first phase (until postnatal 20 days), synapse turnover is maintained to be high, while in the second phase (after three weeks postnatal), synapse dynamics are highly suppressed, leading to the maturation of the cortical neural network. The transition in synapse dynamics may underlie the pathophysiology of neurodevelopmental disorders and psychiatric diseases, but their precise mechanisms have not yet been clarified. Our laboratory has focused on (1) the diverse mechanisms in neural circuits and synapse formation, (2) the structure-function relationship in dynamic synaptic changes, and (3) the relationship between brain diseases and synaptic dysfunction. In particular, we have recently developed new tools for studying neural circuits, such as quantitative methods for analyzing the nano-structure of spine synapses and methods for measuring the molecular dynamics inside spines. Furthermore, we are applying these tools to the study of brain pathology. In this talk, I will introduce these researches and discuss the validity and prospects of understanding the pathogenesis of psychiatric disorders as synaptic dysfunction.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75518180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alleviative effect of glutamate on 5-fluorouracil-induced intestinal mucositis in mice 谷氨酸对5-氟尿嘧啶致小鼠肠道黏膜炎的缓解作用
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-ss-61
S. Jonan, Ayana Fujiwara, K. Iwata, S. Kato, K. Amagase
{"title":"Alleviative effect of glutamate on 5-fluorouracil-induced intestinal mucositis in mice","authors":"S. Jonan, Ayana Fujiwara, K. Iwata, S. Kato, K. Amagase","doi":"10.1254/jpssuppl.95.0_1-ss-61","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-61","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75554136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of itch and modulation of inflammation by IL-31-responsive sensory neurons il -31反应性感觉神经元对瘙痒的诱导和炎症的调节
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-s25-1
Okada Takaharu
{"title":"Induction of itch and modulation of inflammation by IL-31-responsive sensory neurons","authors":"Okada Takaharu","doi":"10.1254/jpssuppl.95.0_2-s25-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-s25-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75709903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol attenuates age-related muscle atrophy and motor dysfunction by promoting autophagy in mice 白藜芦醇通过促进小鼠自噬来减轻与年龄相关的肌肉萎缩和运动功能障碍
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-yia-44
R. Hosoda, A. Kuno, Ryuta Nakashima, S. Asakura, N. Iwahara, Iyori Nojima, Risa Kunimoto, Y. Horio
{"title":"Resveratrol attenuates age-related muscle atrophy and motor dysfunction by promoting autophagy in mice","authors":"R. Hosoda, A. Kuno, Ryuta Nakashima, S. Asakura, N. Iwahara, Iyori Nojima, Risa Kunimoto, Y. Horio","doi":"10.1254/jpssuppl.95.0_2-yia-44","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-yia-44","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73949551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between new neurons and astrocytes in the post-stroke brain 脑卒中后新神经元和星形胶质细胞之间的相互作用
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-s38-4
Kaneko Naoko
{"title":"Interaction between new neurons and astrocytes in the post-stroke brain","authors":"Kaneko Naoko","doi":"10.1254/jpssuppl.96.0_4-b-s38-4","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s38-4","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72611330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orphan G protein-coupled receptor GPR35 contributes to the pathogenesis of dextran sulfate sodium-induced colitis in mice. 孤儿G蛋白偶联受体GPR35参与了硫酸葡聚糖钠诱导小鼠结肠炎的发病机制。
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-p-056
Ayaka Kishi, Yuu Tachibana, Yui Murase, Koga Tokuyama, M. Saito, Hiroyuki Yasuda, Kenjiro Matsumoto, S. Kato
{"title":"Orphan G protein-coupled receptor GPR35 contributes to the pathogenesis of dextran sulfate sodium-induced colitis in mice.","authors":"Ayaka Kishi, Yuu Tachibana, Yui Murase, Koga Tokuyama, M. Saito, Hiroyuki Yasuda, Kenjiro Matsumoto, S. Kato","doi":"10.1254/jpssuppl.96.0_1-b-p-056","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-p-056","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78629262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of extracellular vesicles in disease: a novel tool for understanding disease mechanism? 细胞外囊泡在疾病中的作用:了解疾病机制的新工具?
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-w05-2
Yoshioka Yusuke
{"title":"Role of extracellular vesicles in disease: a novel tool for understanding disease mechanism?","authors":"Yoshioka Yusuke","doi":"10.1254/jpssuppl.96.0_1-b-w05-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-w05-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78729311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Downregulation of astrocytic connexin43 potentiates the antidepressant-induced brain-derived neurotrophic factor expression 星形细胞连接蛋白43的下调增强了抗抑郁药诱导的脑源性神经营养因子的表达
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-yia-15
Tokunaga Nozomi, Yoki Nakamura, K. Nakashima, N. Morioka
{"title":"Downregulation of astrocytic connexin43 potentiates the antidepressant-induced brain-derived neurotrophic factor expression","authors":"Tokunaga Nozomi, Yoki Nakamura, K. Nakashima, N. Morioka","doi":"10.1254/jpssuppl.95.0_1-yia-15","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-yia-15","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76001583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Molecule-Specific Oxidative Modification Inhibitor 分子特异性氧化修饰抑制剂的研究进展
Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-s17-2
Takashi Uehara
{"title":"Development of Molecule-Specific Oxidative Modification Inhibitor","authors":"Takashi Uehara","doi":"10.1254/jpssuppl.96.0_2-b-s17-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s17-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72659880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Proceedings for Annual Meeting of The Japanese Pharmacological Society
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1