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Telephone-Guided Sleep Restriction for Insomnia: A Randomized Sleep Diary-Controlled Trial. 电话引导睡眠限制失眠:一项随机睡眠日记对照试验。
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-03-21 DOI: 10.1159/000545138
Mathilde I Looman, Tessa F Blanken, Tim M Schoenmakers, Joyce E Reesen, Marieke Effting, Floris E Linnebank, Annemieke van Straten, Jan H Kamphuis, Jaap Lancee

Introduction: Insomnia is common, but access to its first-line treatment, cognitive behavioral therapy for insomnia (CBT-I), is limited. To explore a scalable alternative, we investigated the efficacy of sleep restriction therapy (SRT), a core component of CBT-I, delivered via telephone.

Methods: In a randomized controlled trial, 147 adults with insomnia were allocated to 6 weeks of telephone-guided SRT (n = 76) or a sleep diary control group (n = 71). The SRT group received weekly supporting phone calls lasting 10-15 min. At baseline and posttest, we measured insomnia severity (primary outcome), sleep diary measures, anxiety symptoms, depressive symptoms, presleep arousal, sleep-safety behaviors, daytime sleepiness, and dysfunctional sleep-related cognitions (secondary outcomes). The SRT group repeated these measures at 3- and 6-month follow-ups.

Results: Telephone-guided SRT showed large between-group effects on insomnia severity at posttest relative to the sleep diary control group (d = 1.52; p < 0.001). Based on intention-to-treat, 36 (47%) participants randomized to SRT achieved clinical improvement, and 23 (30%) achieved insomnia remission. We found medium-to-large between-group effects at posttest (d = 0.53-1.18) for all secondary outcomes except daytime sleepiness and total sleep time. At 3- and 6-month follow-ups, the primary and all secondary outcomes, including daytime sleepiness and total sleep time, improved relative to baseline within the SRT group (d = 0.50-1.93).

Conclusion: This trial shows that telephone-guided SRT is an effective insomnia treatment requiring minimal therapist guidance. If direct comparisons with CBT-I corroborate these findings, SRT could be an interesting scalable alternative to CBT-I as a first-line insomnia treatment.

Trial registry: NCT05548907.

简介:失眠是一种常见病,但其一线治疗方法--失眠认知行为疗法(CBT-I)却很有限。为了探索一种可扩展的替代方法,我们研究了通过电话提供的睡眠限制疗法(SRT)的疗效,该疗法是 CBT-I 的核心组成部分:在一项随机对照试验中,147 名成人失眠患者被分配到为期 6 周的电话指导 SRT 组(76 人)或睡眠日记对照组(71 人)。SRT组每周接受10至15分钟的电话支持。在基线和测试后,我们测量了失眠严重程度(主要结果)、睡眠日记测量、焦虑症状、抑郁症状、睡前唤醒、睡眠安全行为、白天嗜睡以及与睡眠相关的功能障碍认知(次要结果)。SRT组在3个月和6个月的随访中重复这些测量:与睡眠日记对照组相比,电话指导的 SRT 在测试后对失眠严重程度的组间影响较大(d = 1.52;p < .001)。根据意向治疗,36 名(47%)随机接受 SRT 治疗的参与者临床症状得到改善,23 名(30%)失眠症状得到缓解。我们发现,除白天嗜睡和总睡眠时间外,所有次要结果在测试后均有中等至较大的组间效应(d = 0.53 至 1.18)。在 3 个月和 6 个月的随访中,SRT 组的主要结果和所有次要结果,包括白天嗜睡和总睡眠时间,都比基线有所改善(d = 0.50 至 1.93):这项试验表明,电话指导下的 SRT 是一种有效的失眠治疗方法,只需治疗师提供最低限度的指导。如果与 CBT-I 的直接比较证实了这些发现,SRT 可能会成为 CBT-I 的一种有趣的可扩展替代疗法,作为一线失眠治疗方法:NCT05548907.
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引用次数: 0
Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson's Disease: A Randomized Clinical Trial. 冥想和瑜伽对帕金森病患者焦虑、抑郁和慢性炎症的影响:一项随机临床试验
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1159/000543457
Jojo Yan Yan Kwok, Lily Man Lee Chan, Charis Ann Lai, Philip Wing Lok Ho, Zoe Yuen-Kiu Choi, Man Auyeung, Shirley Yin Yu Pang, Edmond Pui Hang Choi, Daniel Yee Tak Fong, Doris Sau Fung Yu, Chia-Chin Lin, Richard Walker, Samuel Yeung Shan Wong, Rainbow Tin Hung Ho
<p><strong>Introduction: </strong>Clinical guidelines recommend a holistic approach to Parkinson's disease (PD) care, yet randomized trials examining mindfulness-based interventions in this context are scarce. This study investigated the effects of two mindfulness practices - meditation and yoga - on biopsychosocial outcomes in PD patients, including anxiety symptoms, depressive symptoms, motor/nonmotor symptoms, health-related quality-of-life (HRQOL), mindfulness, and stress and inflammation biomarkers, compared to usual care.</p><p><strong>Methods: </strong>159 participants with a clinical diagnosis of idiopathic PD and a Hoehn and Yahr stage of 1, 2, and 3, were randomized into meditation (n = 53), yoga (n = 52), and control (n = 54). Meditation and yoga were delivered in 90-min groups for 8 weeks. Primary outcomes included anxiety symptoms and depressive symptoms. Secondary outcomes included motor and nonmotor symptoms, HRQOL, mindfulness, and serum levels of interleukin-6, cortisol and TNF-alpha. Assessments were done at baseline (T0), 2 months (T1), and 6 months (T2). Linear mixed models were conducted following intention-to-treat principle.</p><p><strong>Results: </strong>Compared to control, both meditation, and yoga groups had significant improvements in anxiety symptoms (meditation: mean difference [MD] = -1.36, 95% CI: -2.46 to-0.26; yoga: MD = -1.61, CI: -2.70 to -0.52), motor symptoms (meditation: MD = -5.35, CI: -8.61 to-2.09; yoga: MD = -6.59, CI: -9.82 to-3.36), HRQOL (meditation: MD = -2.01, CI: -3.41 to-0.62; yoga: MD = -1.45, CI: -2.83 to-0.08), and describing skills (meditation: MD = 0.97, CI: 0.04-1.89; yoga: MD = 0.92, CI: 0.01-1.84) at T1, and significant reductions in serum interleukin-6 levels (meditation: MD = -1.14, CI: -2.18 to-0.10; yoga: MD = -1.11, CI: -2.09 to-0.13) at T2. Only meditation significantly reduced depression (MD = -1.44, CI: -2.57 to-0.30) at T1 and sustained the motor and HRQOL improvements at T2.</p><p><strong>Conclusion: </strong>Meditation and yoga significantly improved anxiety symptoms, chronic inflammation, motor symptoms, mindfulness-describing facet, and HRQOL in PD patients. Meditation provided additional benefits in reducing depressive symptoms and sustaining motor and HRQOL improvements.</p><p><strong>Introduction: </strong>Clinical guidelines recommend a holistic approach to Parkinson's disease (PD) care, yet randomized trials examining mindfulness-based interventions in this context are scarce. This study investigated the effects of two mindfulness practices - meditation and yoga - on biopsychosocial outcomes in PD patients, including anxiety symptoms, depressive symptoms, motor/nonmotor symptoms, health-related quality-of-life (HRQOL), mindfulness, and stress and inflammation biomarkers, compared to usual care.</p><p><strong>Methods: </strong>159 participants with a clinical diagnosis of idiopathic PD and a Hoehn and Yahr stage of 1, 2, and 3, were randomized into meditation (n = 53), yo
临床指南推荐帕金森病(PD)护理的整体方法,然而在这种情况下检查基于正念的干预措施的随机试验很少。本研究调查了两种正念练习——冥想和瑜伽——对PD患者的生物心理社会结果的影响,包括焦虑症状、抑郁症状、运动/非运动症状、健康相关生活质量(HRQOL)、正念、压力和炎症生物标志物。方法:159名临床诊断为特发性PD, Hoehn和Yahr分期为1、2和3期的参与者被随机分为冥想组(n = 53)、瑜伽组(n = 52)和对照组(n = 54)。冥想和瑜伽以90分钟为一组,持续8周。主要结局包括焦虑症状和抑郁症状。次要结局包括运动和非运动症状、HRQOL、正念、血清白细胞介素-6、皮质醇和tnf - α水平。在基线(T0)、2个月(T1)和6个月(T2)进行评估。线性混合模型遵循意向-治疗原则。结果:与对照组相比,冥想组和瑜伽组在焦虑症状方面都有显著改善(冥想组:平均差异[MD] = -1.36, 95% CI: -2.46 -0.26;瑜伽:MD = -1.61, CI: -2.70至-0.52),运动症状(冥想:MD = -5.35, CI: -8.61至2.09;瑜伽:MD = -6.59, CI: -9.82 -3.36), HRQOL(冥想:MD = -2.01, CI: -3.41 -0.62;瑜伽:MD = -1.45, CI: -2.83 -0.08),描述技能(冥想:MD = 0.97, CI: 0.04-1.89;瑜伽:MD = 0.92, CI: 0.01-1.84),血清白细胞介素-6水平显著降低(冥想:MD = -1.14, CI: -2.18 -0.10;瑜伽:MD = -1.11, CI: -2.09 -0.13)。只有冥想在T1时显著减少抑郁(MD = -1.44, CI: -2.57 -0.30),并在T2时维持运动和HRQOL的改善。结论:冥想和瑜伽可显著改善PD患者的焦虑症状、慢性炎症、运动症状、正念描述关节面和HRQOL。冥想在减少抑郁症状和维持运动和HRQOL改善方面提供了额外的好处。
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引用次数: 0
Eye Movement Desensitization and Reprocessing with and without Dialectical Behavior Therapy for Posttraumatic Stress Disorder and Comorbid Borderline Personality Disorder Symptoms: A Randomized Controlled Trial. 眼动脱敏和再加工有无辩证行为治疗创伤后应激障碍和共病边缘型人格障碍症状:一项随机对照试验。
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-02-27 DOI: 10.1159/000544918
Aishah Cecile Snoek, Arne van den End, Aartjan T F Beekman, Jack Dekker, Inga Aarts, Matthijs Blankers, Chris Vriend, Odile A van den Heuvel, Nick Lommerse, Kathleen Thomaes

Introduction: Comorbidity between posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD) is prevalent. Despite evidence-based therapies, high rates of nonresponse and dropout persist. This study therefore aimed to examine whether the concurrent application of eye movement desensitization and reprocessing (EMDR) for PTSD and dialectical behavior therapy (DBT) for BPD yields better results than EMDR alone.

Methods: Patients with a PTSD diagnosis and at least four BPD symptoms were randomly assigned to EMDR (n = 63) or concurrent EMDR-DBT (n = 61). Over 1 year, changes in PTSD symptoms were measured using the Clinician-Administered PTSD Scale for DSM-5. Secondary outcomes included BPD symptoms, global functioning, and quality of life.

Results: Both treatments led to large reductions in PTSD symptoms, without significant differences after 1 year (p = 0.312, d = -0.23, 95% CI = -0.6, 0.1). Both treatments also yielded large and comparable reductions in BPD symptoms and improved quality of life. Global functioning improved only in the EMDR condition according to one measure (World Health Organization Disability Assessment Schedule 2.0), while the other measure (Outcome Questionnaire 45) showed improvements in both groups. Additionally, patients in the EMDR-DBT condition were twice as likely to drop out from EMDR treatment compared to those in the EMDR-only condition.

Conclusion: Stand-alone EMDR demonstrated safety and efficacy in alleviating PTSD and BPD symptoms, as well as enhancing quality of life. These findings support the use of EMDR as a strong therapeutic option for patients with PTSD and comorbid BPD symptoms. Further research is needed to assess longer-term outcomes beyond 1 year.

简介:创伤后应激障碍(PTSD)和边缘型人格障碍(BPD)之间的共病是普遍的。尽管有循证治疗,但无反应和辍学率居高不下。因此,本研究旨在探讨同时应用眼动脱敏和再加工(EMDR)治疗创伤后应激障碍和辩证行为治疗(DBT)治疗BPD是否比单独应用EMDR治疗效果更好。方法:诊断为PTSD且至少有4种BPD症状的患者被随机分配到EMDR (n = 63)或EMDR- dbt同时进行(n = 61)。在一年多的时间里,使用DSM-5的临床应用PTSD量表来测量PTSD症状的变化。次要结局包括BPD症状、整体功能和生活质量。结果:两种治疗方法均显著减轻PTSD症状,一年后无显著差异(p = 0.312, d = -0.23, 95% CI = -0.6, 0.1)。这两种治疗方法也显著减轻了BPD症状,改善了生活质量。根据一项测量(WHODAS 2.0),整体功能仅在EMDR条件下得到改善,而另一项测量(OQ-45)在两组中均显示出改善。此外,EMDR- dbt患者退出EMDR治疗的可能性是单纯EMDR患者的两倍。结论:单独使用EMDR在缓解PTSD和BPD症状以及提高生活质量方面具有安全性和有效性。这些发现支持EMDR作为PTSD和BPD合并症患者强有力的治疗选择。需要进一步的研究来评估一年以上的长期结果。
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引用次数: 0
Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial. 支持正念自助干预作为情绪障碍快速症状改变的辅助治疗:一项面向实践的多中心随机对照试验。
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI: 10.1159/000542937
Yanjuan Li, Yi Zhang, Chun Wang, Jia Luo, Yang Yu, Shixing Feng, Chunxue Wang, Qianwen Xu, Pengchong Wang, Junxuan Chen, Ning Zhang, Qianmei Yu, Yuqing Liu, Danyun Chen, Stefan G Hofmann, Xinghua Liu

Introduction: Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders.

Methods: A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional disorders from four centers. Participants were randomly assigned to either MBSH+TAU (treatment as usual; n = 152) or TAU-only group (n = 150). Assessments were conducted at baseline, week 3, week 5, immediately after intervention and at a 3-month follow-up. Primary outcomes included self-reported and clinician-reported anxiety and depression symptoms. Secondary outcomes included mindfulness, physical symptoms, perceived stress, sleep quality, and inner peace.

Results: The MBSH+TAU group achieved significantly greater improvements in all primary and secondary outcome measures as compared with TAU-only immediately after intervention (Cohen's d = 0.19-0.51). In addition, relatively greater improvements were observed in self-reported depression, mindfulness, physical symptoms, perceived stress, and inner peace as early as week 3 or 5, which were sustained at the 3-month follow-up (Cohen's d = 0.20-0.34).

Conclusions: Facilitator-supported MBSH offers a scalable and effective adjunctive treatment option for patients with emotional disorders in clinical practice, facilitating rapid improvements.

快速缓解症状对情绪障碍患者至关重要。目前的研究旨在确定辅助治疗是否可以为情绪障碍患者提供快速改善。方法:对来自4个中心的302例情绪障碍患者进行面向实践的随机对照试验。参与者被随机分配到MBSH+TAU组(照常治疗;n = 152)或仅tau组(n = 150)。在基线、第3周、第5周、干预后立即和3个月随访时进行评估。主要结局包括自我报告和临床报告的焦虑和抑郁症状。次要结果包括正念、身体症状、感知压力、睡眠质量和内心平静。结果:干预后,MBSH+TAU组与仅TAU组相比,在所有主要和次要结局指标上均取得了显著更大的改善(Cohen’s d = 0.19-0.51)。此外,在自我报告的抑郁、正念、身体症状、感知压力和内心平静方面,早在第3周或第5周就观察到相对较大的改善,并在3个月的随访中持续(Cohen’s d = 0.20-0.34)。结论:促进者支持的MBSH在临床实践中为情绪障碍患者提供了一种可扩展且有效的辅助治疗选择,促进了快速改善。
{"title":"Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial.","authors":"Yanjuan Li, Yi Zhang, Chun Wang, Jia Luo, Yang Yu, Shixing Feng, Chunxue Wang, Qianwen Xu, Pengchong Wang, Junxuan Chen, Ning Zhang, Qianmei Yu, Yuqing Liu, Danyun Chen, Stefan G Hofmann, Xinghua Liu","doi":"10.1159/000542937","DOIUrl":"10.1159/000542937","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders.</p><p><strong>Methods: </strong>A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional disorders from four centers. Participants were randomly assigned to either MBSH+TAU (treatment as usual; n = 152) or TAU-only group (n = 150). Assessments were conducted at baseline, week 3, week 5, immediately after intervention and at a 3-month follow-up. Primary outcomes included self-reported and clinician-reported anxiety and depression symptoms. Secondary outcomes included mindfulness, physical symptoms, perceived stress, sleep quality, and inner peace.</p><p><strong>Results: </strong>The MBSH+TAU group achieved significantly greater improvements in all primary and secondary outcome measures as compared with TAU-only immediately after intervention (Cohen's d = 0.19-0.51). In addition, relatively greater improvements were observed in self-reported depression, mindfulness, physical symptoms, perceived stress, and inner peace as early as week 3 or 5, which were sustained at the 3-month follow-up (Cohen's d = 0.20-0.34).</p><p><strong>Conclusions: </strong>Facilitator-supported MBSH offers a scalable and effective adjunctive treatment option for patients with emotional disorders in clinical practice, facilitating rapid improvements.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"119-129"},"PeriodicalIF":17.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Impact of Metacognitive Interpersonal Therapy on Borderline Personality Disorder: A Retrospective Observational Study Using a Latent Transition Analysis of Symptoms and Functional Changes over 12 Months. 探索元认知人际治疗对边缘型人格障碍的影响:一项回顾性观察研究,使用症状和功能变化的潜在转变分析超过12个月。
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-03-26 DOI: 10.1159/000545385
Matteo Aloi, Antonio Semerari, Giulio Amadei, Ilaria Bucci, Livia Colle, Giuseppe Nicolò, Ilaria Riccardi, Cristina Segura-Garcia, Antonino Carcione

Introduction: Borderline personality disorder (BPD) is marked by emotional instability, interpersonal dysfunction, and high comorbidity, posing significant treatment challenges. Metacognitive Interpersonal Therapy (MIT) targets core features of BPD, including metacognitive impairments and emotional dysregulation. This study used Latent Transition Analysis to assess changes in BPD symptoms and psychological factors over a 12-month MIT intervention, hypothesizing that MIT will reduce symptom severity and improve emotional regulation, metacognitive abilities, and interpersonal functioning.

Methods: This single-center, retrospective, observational study included 98 patients, all diagnosed with BPD according to DSM-IV-TR criteria, without severe psychiatric comorbidities or concurrent psychotherapy. These patients underwent a 12-month MIT intervention, delivered in five phases, targeting metacognitive and emotional regulation skills. Clinical assessments included the Structured Clinical Interview for DSM Axis II Disorders for BPD diagnosis, Symptom Cecklist-90-Revised for symptom severity, Metacognition Assessment Interview for metacognitive abilities, and IIP for interpersonal difficulties.

Results: Latent Class Analysis identified three baseline profiles: "Affective dysregulation and anger" (14.3%), "Low symptomatic" (7.1%), and "Identity and interpersonal sensitivity" (78.6%). After 12 months of treatment, most participants (58.2%) transitioned to a "Recovered" class, with significant reductions in BPD symptoms. The "Recovered" class showed the greatest improvements in metacognitive abilities, emotional regulation, and interpersonal functioning compared to other groups.

Conclusions: MIT was associated with significant improvements in BPD symptoms, with over half of participants achieving full recovery. These findings suggest that MIT may play a role in enhancing emotional regulation and interpersonal functioning. However, residual symptoms in some participants confirm the complexity of BPD, suggesting the need for further research into long-term outcomes and comorbidities.

简介边缘型人格障碍(BPD)的特点是情绪不稳定、人际交往障碍和高并发症,这给治疗带来了巨大挑战。元认知人际疗法(MIT)针对边缘型人格障碍的核心特征,包括元认知障碍和情绪失调。本研究采用潜伏转换分析法(LTA)评估为期12个月的元认知人际关系疗法干预期间BPD症状和心理因素的变化,假设元认知人际关系疗法将减轻症状的严重程度,改善情绪调节、元认知能力和人际关系功能:这项单中心回顾性观察研究共纳入了98名患者,他们均根据DSM-IV-TR标准被诊断为BPD,没有严重的精神并发症,也没有同时接受心理治疗。这些患者接受了为期 12 个月的 MIT 干预,分五个阶段进行,主要针对元认知和情绪调节技能。临床评估包括SCID-II(BPD诊断)、SCL-90-R(症状严重程度)、MAI(元认知能力)和IIP(人际交往障碍):结果:潜类分析(LCA)确定了三种基线特征:"情绪失调和愤怒"(14.3%)、"低症状"(7.1%)和 "身份和人际敏感"(78.6%)。经过 12 个月的治疗后,大多数参与者(58.2%)转入 "康复 "组,BPD 症状显著减少。与其他组别相比,"康复 "组在元认知能力、情绪调节和人际功能方面的改善最大:结论:MIT 与 BPD 症状的显著改善有关,超过一半的参与者实现了完全康复。这些研究结果表明,麻省理工学院可能在增强情绪调节和人际功能方面发挥作用。然而,一些参与者的残余症状证实了 BPD 的复杂性,这表明有必要对长期结果和合并症进行进一步研究。
{"title":"Exploring the Impact of Metacognitive Interpersonal Therapy on Borderline Personality Disorder: A Retrospective Observational Study Using a Latent Transition Analysis of Symptoms and Functional Changes over 12 Months.","authors":"Matteo Aloi, Antonio Semerari, Giulio Amadei, Ilaria Bucci, Livia Colle, Giuseppe Nicolò, Ilaria Riccardi, Cristina Segura-Garcia, Antonino Carcione","doi":"10.1159/000545385","DOIUrl":"10.1159/000545385","url":null,"abstract":"<p><strong>Introduction: </strong>Borderline personality disorder (BPD) is marked by emotional instability, interpersonal dysfunction, and high comorbidity, posing significant treatment challenges. Metacognitive Interpersonal Therapy (MIT) targets core features of BPD, including metacognitive impairments and emotional dysregulation. This study used Latent Transition Analysis to assess changes in BPD symptoms and psychological factors over a 12-month MIT intervention, hypothesizing that MIT will reduce symptom severity and improve emotional regulation, metacognitive abilities, and interpersonal functioning.</p><p><strong>Methods: </strong>This single-center, retrospective, observational study included 98 patients, all diagnosed with BPD according to DSM-IV-TR criteria, without severe psychiatric comorbidities or concurrent psychotherapy. These patients underwent a 12-month MIT intervention, delivered in five phases, targeting metacognitive and emotional regulation skills. Clinical assessments included the Structured Clinical Interview for DSM Axis II Disorders for BPD diagnosis, Symptom Cecklist-90-Revised for symptom severity, Metacognition Assessment Interview for metacognitive abilities, and IIP for interpersonal difficulties.</p><p><strong>Results: </strong>Latent Class Analysis identified three baseline profiles: \"Affective dysregulation and anger\" (14.3%), \"Low symptomatic\" (7.1%), and \"Identity and interpersonal sensitivity\" (78.6%). After 12 months of treatment, most participants (58.2%) transitioned to a \"Recovered\" class, with significant reductions in BPD symptoms. The \"Recovered\" class showed the greatest improvements in metacognitive abilities, emotional regulation, and interpersonal functioning compared to other groups.</p><p><strong>Conclusions: </strong>MIT was associated with significant improvements in BPD symptoms, with over half of participants achieving full recovery. These findings suggest that MIT may play a role in enhancing emotional regulation and interpersonal functioning. However, residual symptoms in some participants confirm the complexity of BPD, suggesting the need for further research into long-term outcomes and comorbidities.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"194-206"},"PeriodicalIF":17.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a Standalone Smartphone Application to Treat Postnatal Depression: A Randomized Controlled Trial. 独立智能手机应用程序治疗产后抑郁症的效果:随机对照试验
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1159/000541311
Pedro F Zuccolo,André R Brunoni,Tatiane Borja,Alicia Matijasevich,Guilherme V Polanczyk,Daniel Fatori
INTRODUCTIONSmartphone app interventions based on cognitive-behavioral therapy (CBT) are promising scalable alternatives for treating mental disorders, but the evidence of their efficacy for postpartum depression is limited. We assessed the efficacy of Motherly, a standalone CBT-based smartphone app, in reducing symptoms of postpartum depression.METHODSWomen aged 18-40 with symptoms of postpartum depression were randomized either to intervention (Motherly app) or active control (COMVC app). The primary outcome was symptoms of depression measured by the Edinburgh Postnatal Depression Scale (EPDS) at post-treatment. Secondary outcomes were anxiety symptoms, parental stress, quality of sleep, behavioral activation, availability of response-contingent positive reinforcement, and clinical improvement at post-treatment and 1-month follow-up. Exploratory analyses were performed to investigate if app engagement was associated with treatment response.RESULTSFrom November 2021 to August 2022, 1,751 women volunteered, of which 264 were randomized, and 215 provided primary outcome data. No statistically significant differences were found between groups at post-treatment: intervention: mean (SD): 12.75 (5.52); active control: 13.28 (5.32); p = 0.604. There was a statistically significant effect of the intervention on some of the secondary outcomes. Exploratory analyses suggest a dose-response relationship between Motherly app engagement and outcomes.CONCLUSIONOur standalone app intervention did not significantly reduce postnatal depression symptoms when compared to active control. Exploratory findings suggest that negative findings might be associated with insufficient app engagement. Consistent with current literature, our findings suggest that standalone app interventions for postpartum depression are not ready to be implemented in clinical practice.
简介:基于认知行为疗法(CBT)的智能手机应用干预是治疗精神障碍的一种很有前景的可扩展替代方法,但其对产后抑郁症的疗效证据却很有限。我们评估了基于 CBT 的独立智能手机应用程序 Motherly 在减轻产后抑郁症状方面的疗效。方法:年龄在 18-40 岁、有产后抑郁症状的女性被随机分配到干预组(Motherly 应用程序)或积极对照组(COMVC 应用程序)。主要结果是治疗后通过爱丁堡产后抑郁量表(EPDS)测量的抑郁症状。次要结果包括焦虑症状、父母压力、睡眠质量、行为激活、反应定向正强化的可用性,以及治疗后和 1 个月随访时的临床改善情况。结果从 2021 年 11 月到 2022 年 8 月,共有 1751 名女性自愿参与,其中 264 人被随机分配,215 人提供了主要结果数据。治疗后各组间无统计学差异:干预组:平均(标清):12.75 (5.52);积极对照组:13.28 (5.32);P = 0.604。干预对一些次要结果的影响具有统计学意义。探索性分析表明,Motherly 应用程序参与度与结果之间存在剂量反应关系。探索性研究结果表明,负面结果可能与应用参与不足有关。与目前的文献一致,我们的研究结果表明,针对产后抑郁的独立应用程序干预还不能在临床实践中实施。
{"title":"Efficacy of a Standalone Smartphone Application to Treat Postnatal Depression: A Randomized Controlled Trial.","authors":"Pedro F Zuccolo,André R Brunoni,Tatiane Borja,Alicia Matijasevich,Guilherme V Polanczyk,Daniel Fatori","doi":"10.1159/000541311","DOIUrl":"https://doi.org/10.1159/000541311","url":null,"abstract":"INTRODUCTIONSmartphone app interventions based on cognitive-behavioral therapy (CBT) are promising scalable alternatives for treating mental disorders, but the evidence of their efficacy for postpartum depression is limited. We assessed the efficacy of Motherly, a standalone CBT-based smartphone app, in reducing symptoms of postpartum depression.METHODSWomen aged 18-40 with symptoms of postpartum depression were randomized either to intervention (Motherly app) or active control (COMVC app). The primary outcome was symptoms of depression measured by the Edinburgh Postnatal Depression Scale (EPDS) at post-treatment. Secondary outcomes were anxiety symptoms, parental stress, quality of sleep, behavioral activation, availability of response-contingent positive reinforcement, and clinical improvement at post-treatment and 1-month follow-up. Exploratory analyses were performed to investigate if app engagement was associated with treatment response.RESULTSFrom November 2021 to August 2022, 1,751 women volunteered, of which 264 were randomized, and 215 provided primary outcome data. No statistically significant differences were found between groups at post-treatment: intervention: mean (SD): 12.75 (5.52); active control: 13.28 (5.32); p = 0.604. There was a statistically significant effect of the intervention on some of the secondary outcomes. Exploratory analyses suggest a dose-response relationship between Motherly app engagement and outcomes.CONCLUSIONOur standalone app intervention did not significantly reduce postnatal depression symptoms when compared to active control. Exploratory findings suggest that negative findings might be associated with insufficient app engagement. Consistent with current literature, our findings suggest that standalone app interventions for postpartum depression are not ready to be implemented in clinical practice.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"1 1","pages":"1-13"},"PeriodicalIF":22.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges for the Moral Injury Construct. 道德伤害结构面临的挑战。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1159/000541281
Richard A Bryant
{"title":"Challenges for the Moral Injury Construct.","authors":"Richard A Bryant","doi":"10.1159/000541281","DOIUrl":"https://doi.org/10.1159/000541281","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"30 1","pages":"1-4"},"PeriodicalIF":22.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of Psychotropic Medication Prescription in Young People: Reflection from the Quebec Experience. 青少年精神药物处方的演变:魁北克经验的反思。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-22 DOI: 10.1159/000541555
Joël Monzée
{"title":"Evolution of Psychotropic Medication Prescription in Young People: Reflection from the Quebec Experience.","authors":"Joël Monzée","doi":"10.1159/000541555","DOIUrl":"https://doi.org/10.1159/000541555","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"63 1","pages":"1-7"},"PeriodicalIF":22.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inference-Based Cognitive Behavioral Therapy versus Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Multisite Randomized Controlled Non-Inferiority Trial. 基于推理的认知行为疗法与认知行为疗法治疗强迫症:多点随机对照非劣效性试验》(Multisite Randomized Controlled Non-Inferiority Trial)。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-18 DOI: 10.1159/000541508
Nadja Wolf,Patricia van Oppen,Adriaan W Hoogendoorn,Odile A van den Heuvel,Harold J G M van Megen,Aniek Broekhuizen,Mirjam Kampman,Daniëlle C Cath,Koen R J Schruers,Saskia M van Es,Tamara Opdam,Anton J L M van Balkom,Henny A D Visser
INTRODUCTIONAlthough cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based cognitive behavioral therapy (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, and addressing obsessional doubt by targeting underlying dysfunctional reasoning, without incorporating an ERP component. We hypothesized that I-CBT would be non-inferior to CBT. Additionally, we hypothesized that I-CBT would be more tolerable than CBT.METHODS197 participants were randomly assigned to 20 sessions CBT or I-CBT and assessed at baseline, posttreatment, and 6 and 12 months' follow-up. The primary outcome was OCD symptom severity measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS; non-inferiority margin: 2 points). The secondary outcome, treatment tolerability, was assessed using the Treatment Acceptability/Adherence Scale (TAAS). A linear mixed-effects model was used to assess the non-inferiority of the primary outcome and superiority of secondary outcomes.RESULTSStatistically significant within-group improvements in the primary and secondary outcomes were observed in both treatments. No statistically significant between-group differences in Y-BOCS were found at any assessment point, but the confidence intervals exceeded the non-inferiority threshold, making the results inconclusive. The estimated mean posttreatment TAAS score was significantly higher in the I-CBT group than in the CBT group.CONCLUSIONWhile both CBT and I-CBT are effective for OCD, whether I-CBT is non-inferior to CBT in terms of OCD symptom severity remains inconclusive. Nevertheless, I-CBT offers better tolerability and warrants consideration as an alternative treatment for OCD.
简介虽然认知行为疗法(CBT)能有效治疗强迫症(OCD),但许多患者拒绝接受 CBT 或过早放弃,部分原因是对暴露和反应预防(ERP)练习感到焦虑。基于推理的认知行为疗法(I-CBT)侧重于纠正扭曲的推理思维模式,增强基于现实的推理能力,并通过针对潜在的功能障碍推理来解决强迫症疑虑,但不包含ERP成分。我们假设 I-CBT 不会劣于 CBT。此外,我们还假设 I-CBT 比 CBT 更易忍受。方法 197 名参与者被随机分配到 20 个疗程的 CBT 或 I-CBT,并在基线、治疗后、6 个月和 12 个月的随访中接受评估。主要结果是使用耶鲁-布朗强迫症量表(Y-BOCS;非劣效差:2 分)测量的强迫症症状严重程度。次要结果是治疗耐受性,采用治疗可接受性/依从性量表(TAAS)进行评估。采用线性混合效应模型评估主要结果的非劣效性和次要结果的优效性。在任何评估点,Y-BOCS 均未发现具有统计学意义的组间差异,但置信区间超过了非劣效性阈值,因此结果尚无定论。虽然 CBT 和 I-CBT 对强迫症都有效,但就强迫症症状的严重程度而言,I-CBT 是否不劣于 CBT 仍无定论。然而,I-CBT具有更好的耐受性,值得考虑作为强迫症的替代治疗方法。
{"title":"Inference-Based Cognitive Behavioral Therapy versus Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Multisite Randomized Controlled Non-Inferiority Trial.","authors":"Nadja Wolf,Patricia van Oppen,Adriaan W Hoogendoorn,Odile A van den Heuvel,Harold J G M van Megen,Aniek Broekhuizen,Mirjam Kampman,Daniëlle C Cath,Koen R J Schruers,Saskia M van Es,Tamara Opdam,Anton J L M van Balkom,Henny A D Visser","doi":"10.1159/000541508","DOIUrl":"https://doi.org/10.1159/000541508","url":null,"abstract":"INTRODUCTIONAlthough cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based cognitive behavioral therapy (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, and addressing obsessional doubt by targeting underlying dysfunctional reasoning, without incorporating an ERP component. We hypothesized that I-CBT would be non-inferior to CBT. Additionally, we hypothesized that I-CBT would be more tolerable than CBT.METHODS197 participants were randomly assigned to 20 sessions CBT or I-CBT and assessed at baseline, posttreatment, and 6 and 12 months' follow-up. The primary outcome was OCD symptom severity measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS; non-inferiority margin: 2 points). The secondary outcome, treatment tolerability, was assessed using the Treatment Acceptability/Adherence Scale (TAAS). A linear mixed-effects model was used to assess the non-inferiority of the primary outcome and superiority of secondary outcomes.RESULTSStatistically significant within-group improvements in the primary and secondary outcomes were observed in both treatments. No statistically significant between-group differences in Y-BOCS were found at any assessment point, but the confidence intervals exceeded the non-inferiority threshold, making the results inconclusive. The estimated mean posttreatment TAAS score was significantly higher in the I-CBT group than in the CBT group.CONCLUSIONWhile both CBT and I-CBT are effective for OCD, whether I-CBT is non-inferior to CBT in terms of OCD symptom severity remains inconclusive. Nevertheless, I-CBT offers better tolerability and warrants consideration as an alternative treatment for OCD.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"8 1","pages":"1-15"},"PeriodicalIF":22.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Rates and Factors Associated to Psychosomatic Syndromes Assessed Using the Diagnostic Criteria for Psychosomatic Research across Different Clinical Settings. 研究在不同临床环境中使用心身医学研究诊断标准评估心身综合征的比率和相关因素。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-17 DOI: 10.1159/000541404
Wei Xu,Wenhao Jiang,Rongjing Ding,Hong Tao,Yanyong Wang,Yanping Tang,Dongfeng Liang,Yuping Wang,Mingwei Wang,Bingwei Chen,Youyong Kong,Lei Liu,Yingying Yue,Liangliang Tan,Lu Yu,Fiammetta Cosci,Yonggui Yuan,
INTRODUCTIONDiagnostic Criteria for Psychosomatic Research (DCPR) serve as an instrument for identifying and classifying specific psychosomatic syndromes that are not adequately encompassed in standard nosography. The present study aimed at measuring the prevalence of DCPR syndromes in different clinical settings and exploring factors associated to such diagnoses.METHODSA cross-sectional and nationwide study recruited 6,647 patients in different clinical settings: 306 were diagnosed with fibromyalgia (FM), 333 with irritable bowel syndrome, 1,109 with migraine, 2,550 with coronary heart disease (CHD), and 2,349 with type 2 diabetes (T2D). Participants underwent DCPR diagnostic interview and were assessed for depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder 7-Item Scale), and subjective well-being (World Health Organization-5 Well-Being Index). The PsychoSocial Index was used to evaluate global well-being, stress, and abnormal illness behavior. The prevalence of DCPR diagnoses was calculated, and factors associated to such diagnoses were analyzed by logistic regression.RESULTSAlexithymia (64.47%), irritable mood (20.55%), and demoralization (15.60%) were the most prevalent psychosomatic syndromes, with demoralization being most common in FM (49.02%). The factors associated to DCPR diagnoses encompassed high anxiety or abnormal illness behavior, and poor well-being. Notably, stress was found to be associated specifically to FM and T2D, with OR of 1.24 (95% CI: 1.06-1.46) and 1.26 (95% CI: 1.18-1.36), respectively.CONCLUSIONDCPR is a clinically helpful complementary assessment tool in need of being widely implemented in clinical settings in order to have a comprehensive picture of the patients.
导言心身医学研究诊断标准(DCPR)是一种工具,用于识别和分类标准分类学未充分涵盖的特定心身综合征。本研究旨在测量 DCPR 综合征在不同临床环境中的患病率,并探讨与此类诊断相关的因素:其中 306 人被诊断为纤维肌痛 (FM),333 人被诊断为肠易激综合征,1109 人被诊断为偏头痛,2550 人被诊断为冠心病 (CHD),2349 人被诊断为 2 型糖尿病 (T2D)。参与者接受了 DCPR 诊断访谈,并接受了抑郁(患者健康问卷-9)、焦虑(广泛性焦虑症 7 项量表)和主观幸福感(世界卫生组织-5 幸福指数)的评估。心理社会指数用于评估总体幸福感、压力和异常疾病行为。结果亚历山大症(64.47%)、易激惹情绪(20.55%)和士气低落(15.60%)是最常见的心身综合征,其中士气低落在 FM 中最为常见(49.02%)。与 DCPR 诊断相关的因素包括高度焦虑或异常疾病行为,以及幸福感差。值得注意的是,压力特别与 FM 和 T2D 相关,OR 分别为 1.24(95% CI:1.06-1.46)和 1.26(95% CI:1.18-1.36)。
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Psychotherapy and Psychosomatics
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