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Exploring the Impact of Metacognitive Interpersonal Therapy on Borderline Personality Disorder: A Retrospective Observational Study Using a Latent Transition Analysis of Symptoms and Functional Changes over 12 Months. 探索元认知人际治疗对边缘型人格障碍的影响:一项回顾性观察研究,使用症状和功能变化的潜在转变分析超过12个月。
IF 17.4 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2025-03-26 DOI: 10.1159/000545385
Matteo Aloi, Antonio Semerari, Giulio Amadei, Ilaria Bucci, Livia Colle, Giuseppe Nicolò, Ilaria Riccardi, Cristina Segura-Garcia, Antonino Carcione

Introduction: Borderline personality disorder (BPD) is marked by emotional instability, interpersonal dysfunction, and high comorbidity, posing significant treatment challenges. Metacognitive Interpersonal Therapy (MIT) targets core features of BPD, including metacognitive impairments and emotional dysregulation. This study used Latent Transition Analysis to assess changes in BPD symptoms and psychological factors over a 12-month MIT intervention, hypothesizing that MIT will reduce symptom severity and improve emotional regulation, metacognitive abilities, and interpersonal functioning.

Methods: This single-center, retrospective, observational study included 98 patients, all diagnosed with BPD according to DSM-IV-TR criteria, without severe psychiatric comorbidities or concurrent psychotherapy. These patients underwent a 12-month MIT intervention, delivered in five phases, targeting metacognitive and emotional regulation skills. Clinical assessments included the Structured Clinical Interview for DSM Axis II Disorders for BPD diagnosis, Symptom Cecklist-90-Revised for symptom severity, Metacognition Assessment Interview for metacognitive abilities, and IIP for interpersonal difficulties.

Results: Latent Class Analysis identified three baseline profiles: "Affective dysregulation and anger" (14.3%), "Low symptomatic" (7.1%), and "Identity and interpersonal sensitivity" (78.6%). After 12 months of treatment, most participants (58.2%) transitioned to a "Recovered" class, with significant reductions in BPD symptoms. The "Recovered" class showed the greatest improvements in metacognitive abilities, emotional regulation, and interpersonal functioning compared to other groups.

Conclusions: MIT was associated with significant improvements in BPD symptoms, with over half of participants achieving full recovery. These findings suggest that MIT may play a role in enhancing emotional regulation and interpersonal functioning. However, residual symptoms in some participants confirm the complexity of BPD, suggesting the need for further research into long-term outcomes and comorbidities.

简介边缘型人格障碍(BPD)的特点是情绪不稳定、人际交往障碍和高并发症,这给治疗带来了巨大挑战。元认知人际疗法(MIT)针对边缘型人格障碍的核心特征,包括元认知障碍和情绪失调。本研究采用潜伏转换分析法(LTA)评估为期12个月的元认知人际关系疗法干预期间BPD症状和心理因素的变化,假设元认知人际关系疗法将减轻症状的严重程度,改善情绪调节、元认知能力和人际关系功能:这项单中心回顾性观察研究共纳入了98名患者,他们均根据DSM-IV-TR标准被诊断为BPD,没有严重的精神并发症,也没有同时接受心理治疗。这些患者接受了为期 12 个月的 MIT 干预,分五个阶段进行,主要针对元认知和情绪调节技能。临床评估包括SCID-II(BPD诊断)、SCL-90-R(症状严重程度)、MAI(元认知能力)和IIP(人际交往障碍):结果:潜类分析(LCA)确定了三种基线特征:"情绪失调和愤怒"(14.3%)、"低症状"(7.1%)和 "身份和人际敏感"(78.6%)。经过 12 个月的治疗后,大多数参与者(58.2%)转入 "康复 "组,BPD 症状显著减少。与其他组别相比,"康复 "组在元认知能力、情绪调节和人际功能方面的改善最大:结论:MIT 与 BPD 症状的显著改善有关,超过一半的参与者实现了完全康复。这些研究结果表明,麻省理工学院可能在增强情绪调节和人际功能方面发挥作用。然而,一些参与者的残余症状证实了 BPD 的复杂性,这表明有必要对长期结果和合并症进行进一步研究。
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引用次数: 0
Efficacy of a Standalone Smartphone Application to Treat Postnatal Depression: A Randomized Controlled Trial. 独立智能手机应用程序治疗产后抑郁症的效果:随机对照试验
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1159/000541311
Pedro F Zuccolo,André R Brunoni,Tatiane Borja,Alicia Matijasevich,Guilherme V Polanczyk,Daniel Fatori
INTRODUCTIONSmartphone app interventions based on cognitive-behavioral therapy (CBT) are promising scalable alternatives for treating mental disorders, but the evidence of their efficacy for postpartum depression is limited. We assessed the efficacy of Motherly, a standalone CBT-based smartphone app, in reducing symptoms of postpartum depression.METHODSWomen aged 18-40 with symptoms of postpartum depression were randomized either to intervention (Motherly app) or active control (COMVC app). The primary outcome was symptoms of depression measured by the Edinburgh Postnatal Depression Scale (EPDS) at post-treatment. Secondary outcomes were anxiety symptoms, parental stress, quality of sleep, behavioral activation, availability of response-contingent positive reinforcement, and clinical improvement at post-treatment and 1-month follow-up. Exploratory analyses were performed to investigate if app engagement was associated with treatment response.RESULTSFrom November 2021 to August 2022, 1,751 women volunteered, of which 264 were randomized, and 215 provided primary outcome data. No statistically significant differences were found between groups at post-treatment: intervention: mean (SD): 12.75 (5.52); active control: 13.28 (5.32); p = 0.604. There was a statistically significant effect of the intervention on some of the secondary outcomes. Exploratory analyses suggest a dose-response relationship between Motherly app engagement and outcomes.CONCLUSIONOur standalone app intervention did not significantly reduce postnatal depression symptoms when compared to active control. Exploratory findings suggest that negative findings might be associated with insufficient app engagement. Consistent with current literature, our findings suggest that standalone app interventions for postpartum depression are not ready to be implemented in clinical practice.
简介:基于认知行为疗法(CBT)的智能手机应用干预是治疗精神障碍的一种很有前景的可扩展替代方法,但其对产后抑郁症的疗效证据却很有限。我们评估了基于 CBT 的独立智能手机应用程序 Motherly 在减轻产后抑郁症状方面的疗效。方法:年龄在 18-40 岁、有产后抑郁症状的女性被随机分配到干预组(Motherly 应用程序)或积极对照组(COMVC 应用程序)。主要结果是治疗后通过爱丁堡产后抑郁量表(EPDS)测量的抑郁症状。次要结果包括焦虑症状、父母压力、睡眠质量、行为激活、反应定向正强化的可用性,以及治疗后和 1 个月随访时的临床改善情况。结果从 2021 年 11 月到 2022 年 8 月,共有 1751 名女性自愿参与,其中 264 人被随机分配,215 人提供了主要结果数据。治疗后各组间无统计学差异:干预组:平均(标清):12.75 (5.52);积极对照组:13.28 (5.32);P = 0.604。干预对一些次要结果的影响具有统计学意义。探索性分析表明,Motherly 应用程序参与度与结果之间存在剂量反应关系。探索性研究结果表明,负面结果可能与应用参与不足有关。与目前的文献一致,我们的研究结果表明,针对产后抑郁的独立应用程序干预还不能在临床实践中实施。
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引用次数: 0
Challenges for the Moral Injury Construct. 道德伤害结构面临的挑战。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1159/000541281
Richard A Bryant
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引用次数: 0
Evolution of Psychotropic Medication Prescription in Young People: Reflection from the Quebec Experience. 青少年精神药物处方的演变:魁北克经验的反思。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-22 DOI: 10.1159/000541555
Joël Monzée
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引用次数: 0
Inference-Based Cognitive Behavioral Therapy versus Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Multisite Randomized Controlled Non-Inferiority Trial. 基于推理的认知行为疗法与认知行为疗法治疗强迫症:多点随机对照非劣效性试验》(Multisite Randomized Controlled Non-Inferiority Trial)。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-18 DOI: 10.1159/000541508
Nadja Wolf,Patricia van Oppen,Adriaan W Hoogendoorn,Odile A van den Heuvel,Harold J G M van Megen,Aniek Broekhuizen,Mirjam Kampman,Daniëlle C Cath,Koen R J Schruers,Saskia M van Es,Tamara Opdam,Anton J L M van Balkom,Henny A D Visser
INTRODUCTIONAlthough cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based cognitive behavioral therapy (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, and addressing obsessional doubt by targeting underlying dysfunctional reasoning, without incorporating an ERP component. We hypothesized that I-CBT would be non-inferior to CBT. Additionally, we hypothesized that I-CBT would be more tolerable than CBT.METHODS197 participants were randomly assigned to 20 sessions CBT or I-CBT and assessed at baseline, posttreatment, and 6 and 12 months' follow-up. The primary outcome was OCD symptom severity measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS; non-inferiority margin: 2 points). The secondary outcome, treatment tolerability, was assessed using the Treatment Acceptability/Adherence Scale (TAAS). A linear mixed-effects model was used to assess the non-inferiority of the primary outcome and superiority of secondary outcomes.RESULTSStatistically significant within-group improvements in the primary and secondary outcomes were observed in both treatments. No statistically significant between-group differences in Y-BOCS were found at any assessment point, but the confidence intervals exceeded the non-inferiority threshold, making the results inconclusive. The estimated mean posttreatment TAAS score was significantly higher in the I-CBT group than in the CBT group.CONCLUSIONWhile both CBT and I-CBT are effective for OCD, whether I-CBT is non-inferior to CBT in terms of OCD symptom severity remains inconclusive. Nevertheless, I-CBT offers better tolerability and warrants consideration as an alternative treatment for OCD.
简介虽然认知行为疗法(CBT)能有效治疗强迫症(OCD),但许多患者拒绝接受 CBT 或过早放弃,部分原因是对暴露和反应预防(ERP)练习感到焦虑。基于推理的认知行为疗法(I-CBT)侧重于纠正扭曲的推理思维模式,增强基于现实的推理能力,并通过针对潜在的功能障碍推理来解决强迫症疑虑,但不包含ERP成分。我们假设 I-CBT 不会劣于 CBT。此外,我们还假设 I-CBT 比 CBT 更易忍受。方法 197 名参与者被随机分配到 20 个疗程的 CBT 或 I-CBT,并在基线、治疗后、6 个月和 12 个月的随访中接受评估。主要结果是使用耶鲁-布朗强迫症量表(Y-BOCS;非劣效差:2 分)测量的强迫症症状严重程度。次要结果是治疗耐受性,采用治疗可接受性/依从性量表(TAAS)进行评估。采用线性混合效应模型评估主要结果的非劣效性和次要结果的优效性。在任何评估点,Y-BOCS 均未发现具有统计学意义的组间差异,但置信区间超过了非劣效性阈值,因此结果尚无定论。虽然 CBT 和 I-CBT 对强迫症都有效,但就强迫症症状的严重程度而言,I-CBT 是否不劣于 CBT 仍无定论。然而,I-CBT具有更好的耐受性,值得考虑作为强迫症的替代治疗方法。
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引用次数: 0
Study of Rates and Factors Associated to Psychosomatic Syndromes Assessed Using the Diagnostic Criteria for Psychosomatic Research across Different Clinical Settings. 研究在不同临床环境中使用心身医学研究诊断标准评估心身综合征的比率和相关因素。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-17 DOI: 10.1159/000541404
Wei Xu,Wenhao Jiang,Rongjing Ding,Hong Tao,Yanyong Wang,Yanping Tang,Dongfeng Liang,Yuping Wang,Mingwei Wang,Bingwei Chen,Youyong Kong,Lei Liu,Yingying Yue,Liangliang Tan,Lu Yu,Fiammetta Cosci,Yonggui Yuan,
INTRODUCTIONDiagnostic Criteria for Psychosomatic Research (DCPR) serve as an instrument for identifying and classifying specific psychosomatic syndromes that are not adequately encompassed in standard nosography. The present study aimed at measuring the prevalence of DCPR syndromes in different clinical settings and exploring factors associated to such diagnoses.METHODSA cross-sectional and nationwide study recruited 6,647 patients in different clinical settings: 306 were diagnosed with fibromyalgia (FM), 333 with irritable bowel syndrome, 1,109 with migraine, 2,550 with coronary heart disease (CHD), and 2,349 with type 2 diabetes (T2D). Participants underwent DCPR diagnostic interview and were assessed for depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder 7-Item Scale), and subjective well-being (World Health Organization-5 Well-Being Index). The PsychoSocial Index was used to evaluate global well-being, stress, and abnormal illness behavior. The prevalence of DCPR diagnoses was calculated, and factors associated to such diagnoses were analyzed by logistic regression.RESULTSAlexithymia (64.47%), irritable mood (20.55%), and demoralization (15.60%) were the most prevalent psychosomatic syndromes, with demoralization being most common in FM (49.02%). The factors associated to DCPR diagnoses encompassed high anxiety or abnormal illness behavior, and poor well-being. Notably, stress was found to be associated specifically to FM and T2D, with OR of 1.24 (95% CI: 1.06-1.46) and 1.26 (95% CI: 1.18-1.36), respectively.CONCLUSIONDCPR is a clinically helpful complementary assessment tool in need of being widely implemented in clinical settings in order to have a comprehensive picture of the patients.
导言心身医学研究诊断标准(DCPR)是一种工具,用于识别和分类标准分类学未充分涵盖的特定心身综合征。本研究旨在测量 DCPR 综合征在不同临床环境中的患病率,并探讨与此类诊断相关的因素:其中 306 人被诊断为纤维肌痛 (FM),333 人被诊断为肠易激综合征,1109 人被诊断为偏头痛,2550 人被诊断为冠心病 (CHD),2349 人被诊断为 2 型糖尿病 (T2D)。参与者接受了 DCPR 诊断访谈,并接受了抑郁(患者健康问卷-9)、焦虑(广泛性焦虑症 7 项量表)和主观幸福感(世界卫生组织-5 幸福指数)的评估。心理社会指数用于评估总体幸福感、压力和异常疾病行为。结果亚历山大症(64.47%)、易激惹情绪(20.55%)和士气低落(15.60%)是最常见的心身综合征,其中士气低落在 FM 中最为常见(49.02%)。与 DCPR 诊断相关的因素包括高度焦虑或异常疾病行为,以及幸福感差。值得注意的是,压力特别与 FM 和 T2D 相关,OR 分别为 1.24(95% CI:1.06-1.46)和 1.26(95% CI:1.18-1.36)。
{"title":"Study of Rates and Factors Associated to Psychosomatic Syndromes Assessed Using the Diagnostic Criteria for Psychosomatic Research across Different Clinical Settings.","authors":"Wei Xu,Wenhao Jiang,Rongjing Ding,Hong Tao,Yanyong Wang,Yanping Tang,Dongfeng Liang,Yuping Wang,Mingwei Wang,Bingwei Chen,Youyong Kong,Lei Liu,Yingying Yue,Liangliang Tan,Lu Yu,Fiammetta Cosci,Yonggui Yuan,","doi":"10.1159/000541404","DOIUrl":"https://doi.org/10.1159/000541404","url":null,"abstract":"INTRODUCTIONDiagnostic Criteria for Psychosomatic Research (DCPR) serve as an instrument for identifying and classifying specific psychosomatic syndromes that are not adequately encompassed in standard nosography. The present study aimed at measuring the prevalence of DCPR syndromes in different clinical settings and exploring factors associated to such diagnoses.METHODSA cross-sectional and nationwide study recruited 6,647 patients in different clinical settings: 306 were diagnosed with fibromyalgia (FM), 333 with irritable bowel syndrome, 1,109 with migraine, 2,550 with coronary heart disease (CHD), and 2,349 with type 2 diabetes (T2D). Participants underwent DCPR diagnostic interview and were assessed for depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder 7-Item Scale), and subjective well-being (World Health Organization-5 Well-Being Index). The PsychoSocial Index was used to evaluate global well-being, stress, and abnormal illness behavior. The prevalence of DCPR diagnoses was calculated, and factors associated to such diagnoses were analyzed by logistic regression.RESULTSAlexithymia (64.47%), irritable mood (20.55%), and demoralization (15.60%) were the most prevalent psychosomatic syndromes, with demoralization being most common in FM (49.02%). The factors associated to DCPR diagnoses encompassed high anxiety or abnormal illness behavior, and poor well-being. Notably, stress was found to be associated specifically to FM and T2D, with OR of 1.24 (95% CI: 1.06-1.46) and 1.26 (95% CI: 1.18-1.36), respectively.CONCLUSIONDCPR is a clinically helpful complementary assessment tool in need of being widely implemented in clinical settings in order to have a comprehensive picture of the patients.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"104 1","pages":"1-11"},"PeriodicalIF":22.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Kisielewska and Mirucka: The Crucial Aspect of Ownership Illusions Is Their Strength, Not the Method to Induce Them. 回复 Kisielewska 和 Mirucka:所有权幻觉的关键在于其强度,而非诱导方法。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-14 DOI: 10.1159/000541412
Simone C Behrens,Katrin E Giel,Stephan Zipfel
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引用次数: 0
The importance of the appropriate use of terms related to body ownership in research using avatars. 在使用虚拟化身的研究中适当使用与身体所有权相关的术语的重要性。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-14 DOI: 10.1159/000541312
Monika Kisielewska,Beata Mirucka
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引用次数: 0
Innovative Strategies in Evaluation and Treatment of Burnout in Medical Workers. 评估和治疗医务工作者职业倦怠的创新策略。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-11 DOI: 10.1159/000541309
Jenny Guidi,Giovanni A Fava
{"title":"Innovative Strategies in Evaluation and Treatment of Burnout in Medical Workers.","authors":"Jenny Guidi,Giovanni A Fava","doi":"10.1159/000541309","DOIUrl":"https://doi.org/10.1159/000541309","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"43 1","pages":"1-6"},"PeriodicalIF":22.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Conceptual Clarity regarding the Construct of Moral Injury. 提高道德伤害概念的清晰度。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-07 DOI: 10.1159/000540030
Sheila Frankfurt O'Brien,Isabelle Baptista,Philip R Szeszko
BACKGROUNDThe construct of "moral injury" is used widely in the research literature and media to broadly describe the impact of events involving perceived violations of one's sense of right and wrong (herein referred to as "potentially morally injurious events" [PMIEs]).SUMMARYIn this theoretical review, we provided a brief overview of the "moral injury" construct and its limitations including the lack of consensus-drawn boundaries and operational definitions to guide hypothesis-driven research. We discussed whether this construct can be reliably distinguished from established psychiatric diagnoses and psychological constructs and the inherent challenges in separating or classifying the impact of high-magnitude stressful life events that likely form the majority of PMIEs. Assessments that purportedly measure "moral injury" are reviewed and limitations are discussed such as shared measurement variance with established psychological instruments.KEY MESSAGESWe identified conceptual strategies for investigating behavioral and neurobiological features of PMIEs that could be used to inform the field of traumatic stress. We concluded that the construct of "moral injury" may provide an interpretive framework for positing why someone may be beset by guilt, shame, and/or rage whereas existing psychiatric diagnoses such as post-traumatic stress disorder and depression provide comprehensive descriptions regarding what someone might experience following extremely stressful events. We proposed directions to better clarify the boundaries of "moral injury" versus established psychiatric categories that could be used to enhance the conceptualization and assessment of this construct.
背景 "道德伤害 "这一概念在研究文献和媒体中被广泛使用,以广泛描述涉及侵犯个人是非感的事件(此处称为 "潜在道德伤害事件"[PMIEs])所造成的影响。我们讨论了这一概念是否能可靠地与既有的精神诊断和心理概念区分开来,以及在分离或分类高强度生活压力事件的影响时所面临的固有挑战,这些事件可能构成了大多数精神创伤和痛苦事件。我们对声称可以测量 "道德伤害 "的评估方法进行了回顾,并讨论了其局限性,如与既有心理测量工具共同存在的测量差异。我们得出的结论是,"道德伤害 "这一概念可以提供一个解释框架,用于解释为什么某人会被内疚、羞愧和/或愤怒所困扰,而现有的精神诊断(如创伤后应激障碍和抑郁症)则全面描述了某人在经历极端应激事件后可能会经历的情况。我们提出了更好地澄清 "道德伤害 "与既有精神病学类别之间界限的方向,可用于加强对这一概念的概念化和评估。
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引用次数: 0
期刊
Psychotherapy and Psychosomatics
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