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Experiences of families of people living with frontotemporal dementia: a qualitative systematic review. 额颞叶痴呆患者家庭的经验:一项定性的系统回顾
IF 1.7 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-07-01 Epub Date: 2022-04-16 DOI: 10.1111/psyg.12837
Tamami Shiba, Miyae Yamakawa, Yoshimi Endo, Rie Konno, Satoshi Tanimukai

Frontotemporal dementia (FTD) is characterised by atrophy of the frontal and/or temporal lobes. People with FTD show language and emotional disturbances from onset, and communication problems usually affect people with FTD and their families even before diagnosis. These unique characteristics of FTD are not well understood and create substantial problems for people living with FTD and their families. This review explores the experiences of families of people living with FTD. Studies were selected and screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched four bibliographic databases for articles up to February 2021 to identify qualitative data on the experiences of families. The Critical Appraisal Skills Programme checklist for qualitative studies was used to assess all included studies. Of 235 identified articles, we included six studies in the qualitative synthesis. Meta-ethnography was conducted to interpret families' experiences of people living with FTD. The emergent concepts were synthesised into five themes: Something is wrong with my loved one; No one fully understands; Existential pain of caring for a loved one with FTD; Increased burden owing to specific FTD symptoms; and Forced to adapt to new and unique ways of living with a loved one with FTD. This review highlighted families' confusion and suffering (which began in the early stages of the disease, and sometimes before diagnosis) and the difficulty of communicating with people with FTD. These findings have implications for future practice, as they demonstrate the positive effect on family life of appropriate support that is provided early, rather than after the disease has progressed.

额颞叶痴呆(FTD)的特征是额叶和/或颞叶萎缩。患有FTD的人从一开始就表现出语言和情绪障碍,沟通问题通常在诊断之前就已经影响到FTD患者及其家人。人们对FTD的这些独特特征并没有很好地了解,这给FTD患者及其家人带来了很大的问题。这篇综述探讨了FTD患者家庭的经历。根据系统评价和Meta分析指南的首选报告项目选择和筛选研究。我们在四个书目数据库中检索了截至2021年2月的文章,以确定有关家庭经历的定性数据。定性研究的关键评估技能程序检查表用于评估所有纳入的研究。在235篇鉴定的文章中,我们纳入了6篇定性综合研究。Meta -人种志用于解释FTD患者的家庭经历。这些涌现的概念被合成为五个主题:我爱的人出了问题;没有人完全明白;照顾患有FTD的亲人的存在性痛苦;由于特定的FTD症状加重了负担;被迫适应新的独特的生活方式,与患有FTD的爱人一起生活。这篇综述强调了家庭的困惑和痛苦(这始于疾病的早期阶段,有时在诊断之前)以及与FTD患者沟通的困难。这些发现对未来的实践具有启示意义,因为它们证明了早期提供适当支持对家庭生活的积极影响,而不是在疾病进展之后。
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引用次数: 0
A first insight into the clinical manifestation of posttraumatic stress disorder in dementia: a systematic literature review. 首次深入了解痴呆患者创伤后应激障碍的临床表现:系统的文献综述
IF 1.7 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-07-01 Epub Date: 2022-04-26 DOI: 10.1111/psyg.12830
Dorien H E van Dongen, Demi Havermans, Kay Deckers, Miranda Olff, Frans Verhey, Sjacko Sobczak

Posttraumatic stress disorder (PTSD) is a prevalent disorder worldwide and often co-occurs in dementia. Both have a major impact on disease burden and quality of life. PTSD may be difficult to recognize in dementia and a structured diagnostic method is lacking. In order to get insight into the clinical diagnostics of PTSD in dementia, this systematic literature review evaluates the clinical presentation of PTSD and other relevant symptoms in people with dementia. PubMed, PsycINFO, Embase, and CINAHL were searched for all publications through 30 December 2021. Articles were included which met the following criteria: (i) description of at least one case with a current diagnosis of dementia and co-morbid PTSD; (ii) clinical presentation of symptoms being adequately described; (iii) no difference being made between chronic PTSD, PTSD with re-activation, and delayed onset PTSD. Of the 947 identified abstracts, 13 papers met the inclusion criteria and were included (describing 30 cases). Based on our rating, only one case completely fulfilled the DSM-5 criteria of PTSD. Avoidance was only described in three cases. Most commonly described symptoms were irritability and anger (E1, 9%), persistent negative emotional state (D4, 9%), and sleep disturbances (E6, 8%). In 93% of the case reports, other symptoms were also described, i.e. memory problems (58%), screaming (33.3%), and wandering (22.2%). People with dementia who have experienced a traumatic event seem to present, based on our rating method, with insufficient symptoms to meet all criteria for a PTSD DSM-5 diagnosis. The DSM-5 core symptom of avoidance was absent in most of the cases. Clinical presentation consists mainly of symptoms of irritability, anger, persistent negative emotional state, and sleep disturbances, often accompanied by other symptoms. These findings suggest that older people with dementia may have other symptom presentations than people without dementia.

创伤后应激障碍(PTSD)是一种世界范围内普遍存在的疾病,通常与痴呆共同发生。两者都对疾病负担和生活质量产生重大影响。在痴呆症中,PTSD可能难以识别,并且缺乏结构化的诊断方法。为了深入了解PTSD在痴呆中的临床诊断,本研究对痴呆患者PTSD及其他相关症状的临床表现进行了系统的文献综述。检索PubMed、PsycINFO、Embase和CINAHL截至2021年12月30日的所有出版物。纳入符合以下标准的文章:(i)描述至少一个当前诊断为痴呆和合并PTSD的病例;(ii)充分描述症状的临床表现;(iii)慢性创伤后应激障碍、再激活创伤后应激障碍和延迟性创伤后应激障碍之间没有差异。947篇摘要中,13篇符合纳入标准(描述了30例病例)。根据我们的评分,只有一个病例完全符合PTSD的DSM - 5标准。只有三个案例描述了逃避。最常见的症状是易怒和愤怒(E1, 9%),持续的消极情绪状态(D4, 9%)和睡眠障碍(E6, 8%)。在93%的病例报告中,还描述了其他症状,即记忆问题(58%),尖叫(33.3%)和徘徊(22.2%)。根据我们的评定方法,经历过创伤性事件的痴呆患者似乎没有足够的症状满足PTSD DSM - 5诊断的所有标准。大多数病例不存在DSM - 5逃避的核心症状。临床表现主要有烦躁、愤怒、持续的消极情绪状态、睡眠障碍等症状,常伴有其他症状。这些发现表明,老年痴呆症患者可能比没有痴呆症的人有其他症状表现。
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引用次数: 0
Cognitive, psychological and social factors associated with older adults' mobility: a scoping review of self-report and performance-based measures. 与老年人行动能力相关的认知、心理和社会因素:自我报告和基于表现的测量的范围综述
IF 1.7 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-07-01 Epub Date: 2022-05-09 DOI: 10.1111/psyg.12848
Michael E Kalu, Vanina Dal Bello-Haas, Meridith Griffin, Sheila Boamah, Jocelyn Harris, Mashal Zaide, Daniel Rayner, Nura Khattab, Salma Abrahim, Tristan K Richardson, Nicholas Savatteri, Yimo Wang, Christian Tkachyk

Although many factors have been associated with mobility among older adults, there is paucity of research that explores the complexity of factors that influence mobility. This review aims to synthesise the available evidence for factors comprising the cognitive, psychological, and social mobility determinants and their associations with mobility self-reported and performance-based outcomes in older adults (60 years). We followed Arksey and O'Malley's five stages of a scoping review and searched PubMed, EMBASE, PsychINFO, Web of Science, AgeLine, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature and Sociological Abstract databases. Reviewers in pairs independently conducted title, abstract, full-text screening and data extraction. We reported associations by analyses rather than articles because articles reported multiple associations for factors and several mobility outcomes. Associations were categorised as significantly positive, negative, or not significant. We included 183 peer-reviewed articles published in 27 countries, most of which were cross-sectional studies and conducted among community-dwelling older adults. The 183 articles reported 630 analyses, of which 381 (60.5%) were significantly associated with mobility outcomes in the expected direction. For example, older adults with higher cognitive functioning such as better executive functioning had better mobility outcomes (e.g., faster gait speed), and those with poor psychological outcomes, such as depressive symptoms, or social outcomes such as reduced social network, had poorer mobility outcomes (e.g., slower gait speed) compared to their counterparts. Studies exploring the association between cognitive factors, personality (a psychological factor) and self-reported mobility outcomes (e.g., walking for transportation or driving), and social factors and performance-based mobility outcomes in older adults are limited. Understanding the additive relationships between cognitive, psychological, and social factors highlights the complexity of older adults' mobility across different forms of mobility, including independence, use of assistive devices, transportation, and driving.

尽管许多因素与老年人的流动性有关,但很少有研究探讨影响流动性的因素的复杂性。本综述旨在综合包括认知、心理和社会流动性决定因素及其与老年人流动性自我报告和基于表现的结果之间的关联的现有证据(60 年)。我们遵循了Arksey和O’Malley的五个阶段的范围界定审查,并搜索了PubMed、EMBASE、PsychINFO、Web of Science、AgeLine、联合和补充医学数据库、护理和联合健康文献累积索引以及社会学摘要数据库。成对的评审员独立进行标题、摘要、全文筛选和数据提取。我们通过分析而不是文章报告了关联,因为文章报告了多种因素和几种流动结果的关联。关联分为显著阳性、阴性或不显著。我们纳入了在27个国家发表的183篇同行评审文章,其中大多数是在社区老年人中进行的横断面研究。183篇文章报告了630项分析,其中381项(60.5%)与预期方向的流动性结果显著相关。例如,与同龄人相比,具有更高认知功能(如更好的执行功能)的老年人具有更好的行动能力(如更快的步态速度),而具有较差心理结果(如抑郁症状)或社交网络减少等社会结果的老年人的行动能力较差(如较慢步态速度)。探索认知因素、个性(一种心理因素)和自我报告的行动结果(例如,步行代步或开车)与社会因素和老年人基于表现的行动结果之间关系的研究有限。了解认知、心理和社会因素之间的附加关系,突显了老年人在不同形式的行动中的复杂性,包括独立性、辅助设备的使用、交通和驾驶。
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引用次数: 0
Comparison of Rapid Cognitive Screen against Montreal Cognitive Assessment in screening for cognitive impairment in the old and old-old. 快速认知筛查与蒙特利尔认知评估在老年人和老年认知障碍筛查中的比较
IF 1.7 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-07-01 Epub Date: 2022-05-16 DOI: 10.1111/psyg.12841
Matthew Zhixuan Chen, Yiong Huak Chan, Michael Wai Kit Wong, Reshma Aziz Merchant

Background: The Montreal Cognitive Assessment (MoCA) was developed as a screening tool for mild cognitive impairment (MCI). Given the need for a rapid screening test in settings such as primary care, we compare the validity of the Rapid Cognitive Screen (RCS) against the MoCA, and determine cut-off scores in the old and old-old.

Methods: Cross-sectional study involving community-dwelling 'old' (65 to 79 years old) and 'old-old' (≥ 80 years old) without dementia. Cognitive impairment was defined by MoCA score 17 to 22. Validation was done using the receiver operating characteristic (ROC) curve analysis: area under the curve (AUC), sensitivity (Sn), and specificity (Sp).

Results: Of the 183 participants (mean age 72.1 ± 5.2 years),15.8% (n = 29) were classified as cognitively impaired. The overall ROC curve had an AUC of 0.82 (95% CI 0.75-0.90, P < 0.01) with an optimal cut-off of 7/8 on RCS (Sn 0.77, Sp 0.72). The 'old' and 'old-old' group had AUC of 0.82 (95% CI 0.74-0.91, P < 0.01) with 8/9 as optimal cut-off (Sn 0.51, Sp 0.96) and AUC of 0.85 (95% CI 0.66-1.03, P < 0.01) with 7/8 as optimal cut-off (Sn 0.71, Sp 1.00) respectively. In multivariate analysis, age was associated with 0.05 (95% CI -0.10-0.00, P < 0.04) point decrement, while >6 years of education was associated with 0.82 (95% CI 0.32-1.33, P < 0.01) point increment in RCS scores.

Conclusion: The three-item RCS is quick and easy to administer. Although RCS met the criterion for good validity against MoCA in predicting cognitive impairment, its utility as a first-line screening tool needs to be further validated in a large-scale population study.

蒙特利尔认知评估(MoCA)是作为轻度认知障碍(MCI)的筛查工具而开发的。考虑到在初级保健等环境中需要进行快速筛查测试,我们将快速认知筛查(RCS)的有效性与MoCA进行了比较,并确定了老年人和老年人的截断分数。
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引用次数: 0
Day service use and improved Serial 7 and Verbal fluency scores in patients with Alzheimer's disease 阿尔茨海默病患者日间服务的使用和改善的序列7和语言流利性评分
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-17 DOI: 10.1111/psyg.12868
Yasuyuki Honjo, K. Ide, H. Takechi
Day services (DS) are provided as part of the Japanese public nursing care system. Recent studies have suggested a possible relationship between DS use and limited progression of Alzheimer's disease (AD). This study examined in detail the relationship between improvements in cognitive function and DS use in people with AD.
日托服务(DS)是日本公共护理体系的一部分。最近的研究表明,DS的使用与阿尔茨海默病(AD)的有限进展之间可能存在关系。本研究详细探讨了AD患者认知功能的改善与DS使用之间的关系。
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引用次数: 1
Effectiveness of change from suvorexant to lemborexant drug in the treatment of sleep disorders suvorexant改为lemborexant药物治疗睡眠障碍的疗效观察
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-10 DOI: 10.1111/psyg.12858
Kazumaro Okino, Hirohisa Suzuki, Seiji Kondo, H. Tomioka, Takahiro Tokumasu, Hiroki Yamada, A. Iwanami, Atsuko Inamoto
This study aimed to examine the effects of a change in medication from suvorexant to lemborexant among patients with insomnia.
这项研究旨在检验失眠患者从苏维己酯改为乐莫瑞松的药物治疗效果。
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引用次数: 4
Feasibility study of comfort with and use of sleep visualisation data from non‐wearable actigraphy among psychiatric unit staff 精神科工作人员非穿戴式活动记录仪睡眠可视化数据舒适度和使用的可行性研究
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-05 DOI: 10.1111/psyg.12859
R. Odachi, M. Yamakawa, Keisuke Nakashima, T. Kajiwara, Yuko Takeshita, M. Iwase, Junko Tsukuda, Manabu Ikeda
Sleep disorders are a common factor in many psychiatric disorders, and objective observation and assessment of sleep states are important. However, observing the sleep of hospitalised patients in psychiatry units is complex. Polysomnography (PSG), the gold standard for objective sleep observation, is invasive and uncomfortable for the patient because of the sensors attached to the body. In addition, understanding the correct use of PSG systems is often difficult for observers. Wrist-worn actigraphy is an effective tool that is simpler and less invasive than PSG. However, there are unique problems associated with using wrist-worn actigraphy in a psychiatric unit. For patients with psychiatric illnesses, various issues are likely to occur, such as unexpected behaviour caused by hallucinations or cognitive decline that can result in the patient’s inability to correctly wear the device, or a lack of cooperation. Consequently, observation in psychiatric units is often limited to visual checks by nurses, which are considered to have low validity and can interfere with patient sleep. Nemuri Scan (Paramount Bed, Tokyo, Japan) is a non-wearable actigraphy system designed to avoid some of these difficulties. Because the thickness of the Nemuri Scan system is only 1.5 cm and it is placed under a mattress, it is difficult for the user to detect the device under their mattress. Therefore, the Nemuri Scan allows the continuous monitoring of their activities. The sensitivity, specificity, and concordance rate of the Nemuri Scan to PSG are equivalent to those of wearable actigraphy. This device can retrospectively collect and visualise sleep data during hospitalisation and show the patient’s current sleep state via a personal computer in the nurses’ station connected to a local area network using a function called Real-time monitor. However, little attention has been paid to how psychiatrists and psychiatric nurses utilise this technology. The current study aimed to clarify the level of interest in visualised sleep data among healthcare staff, and to explore the ways in which these data are used in a psychiatric unit. The setting of this survey was a 50-bed psychiatric unit in a general hospital with approximately 1000 beds in a major city in western Japan. This psychiatric unit contains an open ward and a closed ward. Nemuri Scan was introduced in all patients’ beds of the open ward and all private patients’ beds of the closed ward. The staff comprised 52 doctors and 25 nurses. The unit has a 10:1 nursing care system and double shifts, with three nurses working the night shift. In this investigation, a questionnaire was distributed three times: first, when the scan was introduced; second, after 3 months; and third, after 9 months. The items in the questionnaire included participants’ basic demographic information (age, gender, and clinical ladder level for nurses only), whether they believed that the data obtained from Nemuri Scan were useful, their motivations
睡眠障碍是许多精神疾病的常见因素,客观观察和评估睡眠状态很重要。然而,在精神科病房观察住院患者的睡眠是复杂的。多导睡眠图(PSG)是客观睡眠观察的金标准,由于传感器连接在身体上,对患者来说是侵入性的和不舒服的。此外,观察者通常很难理解PSG系统的正确使用。腕关节活动描记术是一种比PSG更简单、侵入性更小的有效工具。然而,在精神科病房使用腕关节活动描记术也存在一些独特的问题。对于患有精神疾病的患者来说,可能会出现各种问题,例如幻觉或认知能力下降导致的意外行为,这些行为可能导致患者无法正确佩戴设备,或缺乏合作。因此,在精神科病房的观察通常仅限于护士的视觉检查,这被认为有效性低,可能会干扰患者的睡眠。Nemuri Scan(派拉蒙床,日本东京)是一种不可穿戴的活动描记系统,旨在避免其中的一些困难。由于Nemuri扫描系统的厚度只有1.5厘米,并且它被放置在床垫下,用户很难检测到床垫下的设备。因此,Nemuri扫描允许对其活动进行持续监控。Nemuri扫描对PSG的敏感性、特异性和一致性与可穿戴活动描记术相当。该设备可以回顾性地收集和可视化住院期间的睡眠数据,并通过护士站的个人计算机显示患者当前的睡眠状态,该计算机使用一种名为实时监视器的功能连接到局域网。然而,很少有人关注精神科医生和精神科护士如何利用这项技术。目前的研究旨在阐明医护人员对可视化睡眠数据的兴趣程度,并探索在精神科使用这些数据的方式。这项调查的背景是日本西部一个大城市的一家综合医院的一个有50张床位的精神科病房,大约有1000张床位。这个精神科病房包括一个开放式病房和一个封闭式病房。Nemuri扫描被引入开放病房的所有患者床位和封闭病房的所有私人患者床位。工作人员包括52名医生和25名护士。该单位实行10:1的护理制度,两班倒,有三名护士上夜班。在这项调查中,问卷被分发了三次:第一,当扫描被引入时;第二,3个月后;第三,9个月后。问卷中的项目包括参与者的基本人口统计信息(仅限护士的年龄、性别和临床阶梯水平),他们是否认为从Nemuri Scan获得的数据有用,他们访问设备及其数据的动机,以及他们用来观察患者睡眠状态的日常信息资源。问卷是用放置在精神科病房的平板电脑完成的,病房的医生和护士被要求对问卷做出回应。将回答分为两组(医生和护士),并在表格中按时间进行总结。表1显示了问卷调查结果。在第一次调查中,85%的护士在纸上看到了可视化的数据,35%的护士表示这些数据没有用处。尽管只有30%的医生看到了这些数据,但他们都表示这些信息是值得的。在
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引用次数: 0
Diversity of dopamine transporter images in frontotemporal lobar degeneration‐motor neuron disease 额颞叶变性-运动神经元疾病中多巴胺转运体图像的多样性
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-05 DOI: 10.1111/psyg.12860
R. Kobayashi, S. Kawakatsu, D. Morioka, Akihito Suzuki
Dear Editor, We read with great interest Arafuka et al.’s case report on frontotemporal lobar degeneration (FTLD) with trans-activation response DNA protein 43 (TDP43) type B published in this journal. Their patient exhibited a mildly decreased dopamine transporter (DAT) availability on DAT imaging 1.5 years before the onset of dysphagia. In contrast, severely decreased DAT availability was observed in a patient with a similar disease course, based on our previously reported case without confirmatory autopsy results. The authors associated the discrepancy in the severity of the DAT findings between their patient and ours with the differences in disease stage. Our recent report discussed the reduced striatal DAT availability in six patients with FTLD with motor neuron disease (MND). It included three cases of pathologically confirmed FTLD with TDP-43 type B. Moderate to severe reduction in DAT availability was observed among patients with FTLD-MND. On pathological examination, the degeneration of the substantia nigra was apparent. Meanwhile, the pathological findings for the caudate and putamen varied among patients. The patient in Arafuka et al.’s report had mild degeneration of the substantia nigra and caudate, but there was no apparent putamen damage. The mild DAT reduction in their case was likely due to the mild or minimal degeneration of the substantia nigra, caudate, and putamen, which influenced the DAT imaging results. Based on the findings of our cases and Arafuka et al.’s case, the striatal DAT imaging findings of FTLD with TDP-43 type B varies, depending on the degree of degeneration in the substantia nigra, caudate, and putamen. Another remarkable finding in the case report by Arafuka et al. was the DAT reduction, observed prior to the onset of MND symptoms in their patient. This was consistent with the clinical course of the previously reported patients. Therefore, the development of MND should be considered in FTLD patients with abnormal findings on DAT imaging. More studies on the application of DAT imaging in patients with FTLD are needed.
尊敬的编辑,我们饶有兴趣地阅读了Arafuka等人在本杂志上发表的关于B型反式激活反应DNA蛋白43(TDP43)额颞叶变性(FTLD)的病例报告。他们的患者在吞咽困难发作前1.5年的DAT成像中表现出多巴胺转运体(DAT)的可用性轻度降低。相反,根据我们之前报道的没有证实尸检结果的病例,在一名病程相似的患者中观察到DAT的可用性严重降低。作者将他们的患者和我们的患者之间DAT发现的严重程度差异与疾病分期的差异联系起来。我们最近的报告讨论了6名患有运动神经元疾病(MND)的FTLD患者的纹状体DAT可用性降低。其中包括3例经病理证实的TDP-43 B型FTLD。在FTLD-MND患者中观察到DAT可用性中度至重度降低。经病理检查,黑质变性明显。同时,尾状核和壳核的病理学表现因患者而异。Arafuka等人的报告中的患者黑质和尾状核轻度变性,但没有明显的壳核损伤。在他们的病例中,DAT的轻度降低可能是由于黑质、尾状核和壳核的轻度或轻微变性,这影响了DAT成像结果。根据我们的病例和Arafuka等人的病例,TDP-43 B型FTLD的纹状体DAT成像结果各不相同,这取决于黑质、尾状核和壳核的变性程度。Arafuka等人的病例报告中的另一个显著发现是在患者出现MND症状之前观察到的DAT降低。这与先前报道的患者的临床病程一致。因此,DAT成像异常的FTLD患者应考虑MND的发展。需要对DAT成像在FTLD患者中的应用进行更多的研究。
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引用次数: 0
Elderly abuse, affecting factors and evaluation of life satisfaction: a cross‐sectional study 老年人虐待、影响因素和生活满意度评估:一项横断面研究
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-05 DOI: 10.1111/psyg.12862
Muammer Yılmaz, A. Durmaz, Inci Arikan
The aim of this study was to evaluate the frequency of abuse and its effect on life satisfaction in older adults living in our region.
本研究的目的是评估虐待频率及其对生活在我们地区的老年人生活满意度的影响。
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引用次数: 2
Which reduces the risk of cognitive impairment: physical activity or daytime nap? 哪一种能降低认知障碍的风险:体育活动还是白天小睡?
IF 2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2022-06-05 DOI: 10.1111/psyg.12864
T. Kawada
Dear Editor, Qian et al. conducted a cross-sectional study to investigate the association between three lifestyles and cognitive impairment (COI) in adults aged 60 years or older. The adjusted odds ratios (ORs) (95% confidence intervals (CIs)) of tea consumption, physical activity for COI were 0.66 (0.48–0.90) and 0.79 (0.65–0.96), respectively. In addition, the adjusted OR (95% CI) of physical activity plus siesta for COI was 0.44 (0.31–0.64). Although almost all combinations of lifestyle factors had a significant negative association with COI, the adjusted OR of tea consumption plus siesta for COI did not reach the level of significance. Tea consumption and siesta are lifestyles without body movement, and physical activity may be indispensable to avoid COI. I present some information regarding siesta and cognition. Duan et al. conducted a prospective study to examine the association between sleep characteristics and mild cognitive impairment (MCI) incidence with special reference to apolipoprotein E polymorphism ε4 (APOEε4). The adjusted hazard ratios (HRs) (95% CIs) of taking a nap at noon for MCI were 0.723 (0.592– 0.883) and 0.719 (0.576–0.897) in all participants and in APOEε4 non-carriers, respectively. They concluded that MCI was protected by nap regardless of APOEε4. Palpatzis et al. reported that the adjusted HR (95% CI) of daytime napping in middle-aged adults for dementia incidence was 1.67 (1.37–2.03). They also observed that the elevated dementia risk was observed regardless of genetic risk by APOE genotype. On this point, the effect of APOE on the association between sleep and incident dementia may differ in middle-aged people and older adults, because the effects of APOEε4 can vary with age and other factors. Furthermore, Riaz et al. reported that APOEε4 presented different risks of cognitive decline and dementia. Anyway, clinical outcome and age should be treated with caution, when APOEε4 is included for the analysis. Finally, Li et al. reported the association between daytime napping and subsequent risk of Alzheimer’s dementia. Longer and more frequent daytime naps were significantly associated with higher risk of Alzheimer’s dementia. In addition, there were bidirectional dose–response relationships between longer and/or more frequent daytime napping and worse levels of cognition. Causal association should be specified by further studies.
尊敬的编辑,钱等人进行了一项横断面研究,调查了60岁及以上成年人的三种生活方式与认知障碍(COI)之间的关系。茶消费量和COI体力活动的校正比值比(OR)(95%置信区间(CI))分别为0.66(0.48-0.90)和0.79(0.65-0.96)。此外,体育活动加午休对COI的校正OR(95%CI)为0.44(0.31–0.64)。尽管几乎所有生活方式因素的组合都与COI呈显著负相关,但喝茶加午休的校正OR对COI没有达到显著水平。喝茶和午休是没有身体运动的生活方式,为了避免COI,体育活动可能是必不可少的。我提供一些关于午睡和认知的信息。段等人进行了一项前瞻性研究,以检查睡眠特征与轻度认知障碍(MCI)发病率之间的关系,特别是参考载脂蛋白E多态性ε4(APOEε4)。所有参与者和APOEε4非携带者中午小睡MCI的调整后危险比(HR)(95%CI)分别为0.723(0.592–0.883)和0.719(0.576–0.897)。他们得出结论,无论APOEε4如何,MCI都受到nap的保护。Palpatzis等人报道,中年人白天打盹对痴呆症发病率的调整HR(95%CI)为1.67(1.37-2.03)。他们还观察到,无论APOE基因型的遗传风险如何,痴呆症风险都会升高。在这一点上,在中年人和老年人中,APOE对睡眠和痴呆事件之间关系的影响可能不同,因为APOEε4的影响可能随年龄和其他因素而变化。此外,Riaz等人报道,APOEε4表现出不同的认知能力下降和痴呆风险。无论如何,当APOEε4被纳入分析时,临床结果和年龄应谨慎对待。最后,李等人报道了日间小睡与阿尔茨海默痴呆症风险之间的关系。白天小睡时间越长、频率越高,患阿尔茨海默氏症的风险越高。此外,白天小睡时间更长和/或更频繁与认知水平较差之间存在双向剂量-反应关系。因果关系应通过进一步研究加以明确。
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Psychogeriatrics
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