Pub Date : 2018-09-01DOI: 10.1515/pteridines-2018-0010
Xiaorong Gao, Shi Ning, Yuanfang Yao
Abstract The aim of this study was to evaluate the clinical efficacy of early enteral nutrition support (EENS) on nitrogen balance and National Institute of Health stroke scale (NIHSS) in elderly patients with acute cerebral stroke and dysphagia. Sixty-eight patients diagnosed with acute brain stroke (ABS) were retrospectively analyzed in our hospital database. Of the included 68 ABS subjects, 37 patients were given early EENS within 72h after ABS diagnosis (experiment group) and the other 31 cases were given a regular liquid diet (control group). The nitrogen balance 1, 2, 3 and 4 weeks after EENS were -4.3 ± 1.3, -3.4 ± 1.1, -2.6 ± 1.2 and -2.0 ± 1.1(g/d) respectively for the experiment group and -8.5 ± 3.1, -7.0 ± 2.4, -6.2 ± 1.5 and -5.7 ± 1.1 (g/d) respectively for the control group. This indicated that the nitrogen balance in the experimental group was significantly higher than that of the control group (p<0.05). After treatment, the NIHSS score were 7.3 ± 2.3 and 7.4 ± 2.4 in the experimental and control groups respectively with statistically significant difference (p<0.05). The risk of developing regurgitation, diarrhea and ventosity in the experimental group were significantly lower than that of the control group (p<0.05). EENS can quickly improve the burden of ABS in elderly patients, elevate the nutritional level and reduce the risk of related complications.
{"title":"Effect of Early Enteral Nutrition Support on Nitrogen Balance and Nihss Score in Elderly Patients With Acute Cerebral Stroke and Dysphagia","authors":"Xiaorong Gao, Shi Ning, Yuanfang Yao","doi":"10.1515/pteridines-2018-0010","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0010","url":null,"abstract":"Abstract The aim of this study was to evaluate the clinical efficacy of early enteral nutrition support (EENS) on nitrogen balance and National Institute of Health stroke scale (NIHSS) in elderly patients with acute cerebral stroke and dysphagia. Sixty-eight patients diagnosed with acute brain stroke (ABS) were retrospectively analyzed in our hospital database. Of the included 68 ABS subjects, 37 patients were given early EENS within 72h after ABS diagnosis (experiment group) and the other 31 cases were given a regular liquid diet (control group). The nitrogen balance 1, 2, 3 and 4 weeks after EENS were -4.3 ± 1.3, -3.4 ± 1.1, -2.6 ± 1.2 and -2.0 ± 1.1(g/d) respectively for the experiment group and -8.5 ± 3.1, -7.0 ± 2.4, -6.2 ± 1.5 and -5.7 ± 1.1 (g/d) respectively for the control group. This indicated that the nitrogen balance in the experimental group was significantly higher than that of the control group (p<0.05). After treatment, the NIHSS score were 7.3 ± 2.3 and 7.4 ± 2.4 in the experimental and control groups respectively with statistically significant difference (p<0.05). The risk of developing regurgitation, diarrhea and ventosity in the experimental group were significantly lower than that of the control group (p<0.05). EENS can quickly improve the burden of ABS in elderly patients, elevate the nutritional level and reduce the risk of related complications.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"91 - 96"},"PeriodicalIF":0.4,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44264321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.1515/pteridines-2018-0007
Hande Sipahl, F. E. Ö. Bayram, Ş. Palabiyik, D. Bayram, A. Aydın
Abstract According to the ISO10993-1 standard medical devices should be evaluated before marketing. Although there are studies that monitor the toxicity of several marketed medical devices, none of them describe the toxicity of masks that are widely used to avoid occupational exposure to biological hazard or toxic chemicals. The aim of this study was to evaluate the biocompatibility of eight purchased surgical masks of different brands, investigating their cytotoxicity and inflammation inducing capacity. Cytotoxicity was assessed via the MTT cell viability assay and inflammation was monitored by measuring nitrite, kynurenine and tryptophan levels. A preliminary study revealed that four samples were capable of killing L929 cells. Therefore the materials composing these masks were also evaluated separately. While the exposure to non-woven materials did not involve any changes in cell survival, exposing cells to elastic and sponge materials led to death in significant levels. Also, significant increases in nitrite levels with a decrease in tryptophan and kynurenine levels were obtained with cells treated with these materials, suggesting an inflammatory response that could be related to the observed cytotoxicity. Our studies revealed that the half of the randomly collected masks did not suit the biocompatibility criteria established by the ISO10993-1 standard, which is a quite unexpected result.
{"title":"Investigation of the Biocompatibility of Surgical Masks","authors":"Hande Sipahl, F. E. Ö. Bayram, Ş. Palabiyik, D. Bayram, A. Aydın","doi":"10.1515/pteridines-2018-0007","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0007","url":null,"abstract":"Abstract According to the ISO10993-1 standard medical devices should be evaluated before marketing. Although there are studies that monitor the toxicity of several marketed medical devices, none of them describe the toxicity of masks that are widely used to avoid occupational exposure to biological hazard or toxic chemicals. The aim of this study was to evaluate the biocompatibility of eight purchased surgical masks of different brands, investigating their cytotoxicity and inflammation inducing capacity. Cytotoxicity was assessed via the MTT cell viability assay and inflammation was monitored by measuring nitrite, kynurenine and tryptophan levels. A preliminary study revealed that four samples were capable of killing L929 cells. Therefore the materials composing these masks were also evaluated separately. While the exposure to non-woven materials did not involve any changes in cell survival, exposing cells to elastic and sponge materials led to death in significant levels. Also, significant increases in nitrite levels with a decrease in tryptophan and kynurenine levels were obtained with cells treated with these materials, suggesting an inflammatory response that could be related to the observed cytotoxicity. Our studies revealed that the half of the randomly collected masks did not suit the biocompatibility criteria established by the ISO10993-1 standard, which is a quite unexpected result.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"80 - 86"},"PeriodicalIF":0.4,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48510484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.1515/PTERIDINES-2018-0008
F. Leblhuber, K. Steiner, J. Gostner, D. Fuchs
Repetitive transcranial magnetic stimulation (rTMS) is used to treat different neuropsychiatric conditions like Parkinson’s disease, essential tremor, stroke, cognitive decline, dementia and depression. rTMS may exert its therapeutic effects by influencing the biochemistry of neurotransmitters. In this exploratory study, safety symptom improvement and changes in the availability of neurotransmitter precursor amino acids were studied following prefrontal cortex (PFC) stimulation using repetitive transcranial stimulation with TheraCell apparatus R (Guth Meditec, Salach, Germany) as an additional treatment in ten patients with late life depression. Treatment was well tolerated with no serious adverse effects being observed. rTMS induced a significant improvement in the symptoms of depression and a significant decrease in the HAMD-7 (p <0.03). At the same time, the serum phenylalanine to tyrosine ratio declined significantly (p <0.04). No significant influence of rTMS on tryptophan breakdown and serum neopterin concentrations was observed. These preliminary findings indicate that rTMS may influence the activity of the enzyme phenylalanine hydroxylase (PAH) which plays a key role in the biosynthesis of neurotransmitter precursors related to neuropsychiatric symptoms in late life depression. However, results were obtained from only 10 patients. Larger studies are therefore required to support these conclusions
{"title":"Repetitive transcranial magnetic stimulation in patients with late life depression influences phenylalanine metabolism","authors":"F. Leblhuber, K. Steiner, J. Gostner, D. Fuchs","doi":"10.1515/PTERIDINES-2018-0008","DOIUrl":"https://doi.org/10.1515/PTERIDINES-2018-0008","url":null,"abstract":"\u0000 Repetitive transcranial magnetic stimulation (rTMS) is used to treat different neuropsychiatric conditions like Parkinson’s disease, essential tremor, stroke, cognitive decline, dementia and depression. rTMS may exert its therapeutic effects by influencing the biochemistry of neurotransmitters. In this exploratory study, safety symptom improvement and changes in the availability of neurotransmitter precursor amino acids were studied following prefrontal cortex (PFC) stimulation using repetitive transcranial stimulation with TheraCell apparatus R (Guth Meditec, Salach, Germany) as an additional treatment in ten patients with late life depression. Treatment was well tolerated with no serious adverse effects being observed. rTMS induced a significant improvement in the symptoms of depression and a significant decrease in the HAMD-7 (p <0.03). At the same time, the serum phenylalanine to tyrosine ratio declined significantly (p <0.04). No significant influence of rTMS on tryptophan breakdown and serum neopterin concentrations was observed. These preliminary findings indicate that rTMS may influence the activity of the enzyme phenylalanine hydroxylase (PAH) which plays a key role in the biosynthesis of neurotransmitter precursors related to neuropsychiatric symptoms in late life depression. However, results were obtained from only 10 patients. Larger studies are therefore required to support these conclusions","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/PTERIDINES-2018-0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44822064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-31DOI: 10.1515/pteridines-2018-0005
M. Knoll, D. Fuchs, G. Weiss, R. Bellmann-Weiler, Bojana Kovrlija, K. Kurz
Abstract Background: Interferon-γ (IFN- γ) regulates the degradation of tryptophan to kynurenine via induction of indoleamine- 2,3-dioxygenase (IDO). Local tryptophan depletion and accumulation of toxic metabolites might impair the proliferative capacity of lymphocytes. The aim of this study was to assess the actual status of immune system activation of patients with bacterial infection in the acute phase and during convalescence in vivo and in vitro. Parameters of systemic immune system activation were evaluated for associations with proliferative responsiveness of immune cells, and compared with healthy controls. Methods: 24 patients with various acute bacterial infections were included in the group of acutely ill patients. Sixteen patients participated in a follow-up examination after convalescence. The control group consisted of 6 healthy people. To assess the status of immune system activation in vivo, inflammation parameters C-reactive protein and differential blood counts were determined. Neopterin concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Tryptophan and kynurenine measurements were performed with high pressure liquid chromatography (HPLC). Peripheral blood mononuclear cells (PBMCs) were isolated from the patients’ blood and stimulated with concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) in vitro proliferation rates were evaluated by ³H-thymidine incorporation and neopterin production and tryptophan degradation were determined in supernatants of mitogen stimulated PBMCs. Results: Patients with acute bacterial infections showed reduced tryptophan and elevated neopterin concentrations, which did not normalize after convalescence period. Higher plasma neopterin values and increased IDO-activity were associated with reduced proliferative responses in vitro after stimulation with PHA. Associations were observed during acute infection as well as convalescence. Conclusions: Results of this study show that increased immune system activation in vivo is associated with impaired proliferative responsiveness of immune cells in vitro in acute bacterial infections as well as during convalescence.
{"title":"Interferon-γ Mediated Pathways And Mitogen Stimulated Proliferation During And After An Acute Infection","authors":"M. Knoll, D. Fuchs, G. Weiss, R. Bellmann-Weiler, Bojana Kovrlija, K. Kurz","doi":"10.1515/pteridines-2018-0005","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0005","url":null,"abstract":"Abstract Background: Interferon-γ (IFN- γ) regulates the degradation of tryptophan to kynurenine via induction of indoleamine- 2,3-dioxygenase (IDO). Local tryptophan depletion and accumulation of toxic metabolites might impair the proliferative capacity of lymphocytes. The aim of this study was to assess the actual status of immune system activation of patients with bacterial infection in the acute phase and during convalescence in vivo and in vitro. Parameters of systemic immune system activation were evaluated for associations with proliferative responsiveness of immune cells, and compared with healthy controls. Methods: 24 patients with various acute bacterial infections were included in the group of acutely ill patients. Sixteen patients participated in a follow-up examination after convalescence. The control group consisted of 6 healthy people. To assess the status of immune system activation in vivo, inflammation parameters C-reactive protein and differential blood counts were determined. Neopterin concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Tryptophan and kynurenine measurements were performed with high pressure liquid chromatography (HPLC). Peripheral blood mononuclear cells (PBMCs) were isolated from the patients’ blood and stimulated with concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) in vitro proliferation rates were evaluated by ³H-thymidine incorporation and neopterin production and tryptophan degradation were determined in supernatants of mitogen stimulated PBMCs. Results: Patients with acute bacterial infections showed reduced tryptophan and elevated neopterin concentrations, which did not normalize after convalescence period. Higher plasma neopterin values and increased IDO-activity were associated with reduced proliferative responses in vitro after stimulation with PHA. Associations were observed during acute infection as well as convalescence. Conclusions: Results of this study show that increased immune system activation in vivo is associated with impaired proliferative responsiveness of immune cells in vitro in acute bacterial infections as well as during convalescence.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"70 - 79"},"PeriodicalIF":0.4,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48865770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-30DOI: 10.1515/pteridines-2018-0006
D. Fuchs, J. Gostner, A. Griesmacher, B. Melichar, G. Reibnegger, G. Weiss, E. Werner
{"title":"37th International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics","authors":"D. Fuchs, J. Gostner, A. Griesmacher, B. Melichar, G. Reibnegger, G. Weiss, E. Werner","doi":"10.1515/pteridines-2018-0006","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0006","url":null,"abstract":"","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"42 - 69"},"PeriodicalIF":0.4,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66815114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-16DOI: 10.1515/pteridines-2018-0002
S. Goswami, M. Das, D. Sain, B. Goswami
Abstract A concise account of pterins in chemistry and biology and their applications in molecular sensors including their optical spectroscopic properties are described. Different natural, synthetic, biological and photophysical aspects are also discussed. Synthetic access to direct functionalised pterins and a recently reported new thiophene annulation technique are described for the synthesis of Form B of molybdenum cofactor. The receptor properties of fluorescent pterin molecules including selenopyrimidines which are rarely reported for their binding of anions and neutral molecules are also of major importance in this review. For such an old and still so young, unexplored pterin system on its power to be sensitive for physical studies especially the interaction with cations, anions and neutral molecules are fascinating and research in this area is relatively new and expected to increase fast. Pterin based receptors are for the first time put into a useful review for the advantage of those who want to explore pterin and modified pterin as chromogenic and fluorogenic sensors.
{"title":"A concise treatment of pterins: some recent synthetic and methodology aspects and their applications in molecular sensors","authors":"S. Goswami, M. Das, D. Sain, B. Goswami","doi":"10.1515/pteridines-2018-0002","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0002","url":null,"abstract":"Abstract A concise account of pterins in chemistry and biology and their applications in molecular sensors including their optical spectroscopic properties are described. Different natural, synthetic, biological and photophysical aspects are also discussed. Synthetic access to direct functionalised pterins and a recently reported new thiophene annulation technique are described for the synthesis of Form B of molybdenum cofactor. The receptor properties of fluorescent pterin molecules including selenopyrimidines which are rarely reported for their binding of anions and neutral molecules are also of major importance in this review. For such an old and still so young, unexplored pterin system on its power to be sensitive for physical studies especially the interaction with cations, anions and neutral molecules are fascinating and research in this area is relatively new and expected to increase fast. Pterin based receptors are for the first time put into a useful review for the advantage of those who want to explore pterin and modified pterin as chromogenic and fluorogenic sensors.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"15 - 41"},"PeriodicalIF":0.4,"publicationDate":"2018-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48663613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-02DOI: 10.1515/pteridines-2018-0001
S. Ünüvar, Hamza Aslanhan, Z. Tanrıverdi, Fuat Karakuş
Hepatitis B is a life-threatening viral liver infection caused by the hepatitis B virus. Neopterin is regarded as an immunologic biomarker of several diseases related to activation of the cellular immune system. Hepatitis B infection is associated with increased production of cellular immune system markers. We aimed to investigate whether there is a relationship between hepatitis B surface antigen-positivity (HBsAg +) and neopterin to determine the role of neopterin in the early diagnosis of hepatitis B infections. Seventy-two HBsAg (+) patients with normal liver function tests and forty-three controls were included in the study. Neopterin levels were 17.6 ± 0.13 nmol/L in HBsAg (+) patients; and 9.12 ± 0.09 nmol/L in infection-free controls, respectively. Compared to the control group, a statistically significant increase (p < 0.001) in the serum neopterin levels of the patients was observed. No significant relationship was determined between neopterin levels and age/sex (both, p > 0.05). With overstimulation of interferon-gamma, the production of neopterin increases by monocytes/macrophages. Likewise with other diseases associated with an activated cellular immune system, this study shows that neopterin can be a predictive biomarker for persistent carriers of hepatitis B infection.
{"title":"The relationship between neopterin and hepatitis B surface antigen positivity","authors":"S. Ünüvar, Hamza Aslanhan, Z. Tanrıverdi, Fuat Karakuş","doi":"10.1515/pteridines-2018-0001","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0001","url":null,"abstract":"Hepatitis B is a life-threatening viral liver infection caused by the hepatitis B virus. Neopterin is regarded as an immunologic biomarker of several diseases related to activation of the cellular immune system. Hepatitis B infection is associated with increased production of cellular immune system markers. We aimed to investigate whether there is a relationship between hepatitis B surface antigen-positivity (HBsAg +) and neopterin to determine the role of neopterin in the early diagnosis of hepatitis B infections. Seventy-two HBsAg (+) patients with normal liver function tests and forty-three controls were included in the study. Neopterin levels were 17.6 ± 0.13 nmol/L in HBsAg (+) patients; and 9.12 ± 0.09 nmol/L in infection-free controls, respectively. Compared to the control group, a statistically significant increase (p < 0.001) in the serum neopterin levels of the patients was observed. No significant relationship was determined between neopterin levels and age/sex (both, p > 0.05). With overstimulation of interferon-gamma, the production of neopterin increases by monocytes/macrophages. Likewise with other diseases associated with an activated cellular immune system, this study shows that neopterin can be a predictive biomarker for persistent carriers of hepatitis B infection.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"1 - 5"},"PeriodicalIF":0.4,"publicationDate":"2018-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43114188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-02DOI: 10.1515/pteridines-2018-0003
R. Pilka, D. Neubert, D. Stejskal, G. Krejčí, M. Švesták, R. Marek, T. Adam, K. Sobková, D. Ondrová, J. Hambálek, M. Maděrka, D. Solichová, L. Kujovská Krčmová, L. Javorská, B. Melichar
Abstract To compare preoperative intestinal trefoil factor 3 (TFF3), allograft inflammatory factor-1 (AIF-1) and calgizzarin (S100-A11) serum levels in patients with endometrial cancer, endometrial hyperplasia and in healthy female controls. Serum levels of TFF3, S100- A11 and AIP-1 were analyzed in 98 consecutive patients with histologically verified endometrial cancer, in 43 patients with endometrial hyperplasia diagnosed during hysteroscopy and 24 controls with benign disease. Results were correlated with urinary neopterin/creatinine ratio, serum kynurenine, tryptophan, retinol, alpha-tocopherol, vitamin D, citrulline, C-reactive protein, interleukin-6 and clinical characteristics. S100-A11, and AIF-1 levels were higher in endometrial hyperplasia patients than in controls, and also significantly higher in endometrial cancer than in patients with endometrial hyperplasia. Serum concentrations of TFF3 and S100-A11 were associated with tumor stage and lymph node status. TFF3 exhibited positive correlation with age, IL-6, vitamin D, kynurenine, urinary neopterin/creatinine ratio and kynurenine/tryptophan ratio. S100-A11, as well as AIF-1 correlated positively with Il-6 and TFF3. TFF3, S100-A11 and AIF-1 represent potential biomarkers in patients with endometrial cancer. TFF3 and S100-A11 increase with tumor stage and lymph node involvement, reflecting higher tumor mass that is also associated with increased concentration of biomarkers of immune dysfunction.
{"title":"Serum concentrations of TFF3, S100-A11 and AIF-1 in association with systemic inflammatory response, disease stage and nodal involvement in endometrial cancer","authors":"R. Pilka, D. Neubert, D. Stejskal, G. Krejčí, M. Švesták, R. Marek, T. Adam, K. Sobková, D. Ondrová, J. Hambálek, M. Maděrka, D. Solichová, L. Kujovská Krčmová, L. Javorská, B. Melichar","doi":"10.1515/pteridines-2018-0003","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0003","url":null,"abstract":"Abstract To compare preoperative intestinal trefoil factor 3 (TFF3), allograft inflammatory factor-1 (AIF-1) and calgizzarin (S100-A11) serum levels in patients with endometrial cancer, endometrial hyperplasia and in healthy female controls. Serum levels of TFF3, S100- A11 and AIP-1 were analyzed in 98 consecutive patients with histologically verified endometrial cancer, in 43 patients with endometrial hyperplasia diagnosed during hysteroscopy and 24 controls with benign disease. Results were correlated with urinary neopterin/creatinine ratio, serum kynurenine, tryptophan, retinol, alpha-tocopherol, vitamin D, citrulline, C-reactive protein, interleukin-6 and clinical characteristics. S100-A11, and AIF-1 levels were higher in endometrial hyperplasia patients than in controls, and also significantly higher in endometrial cancer than in patients with endometrial hyperplasia. Serum concentrations of TFF3 and S100-A11 were associated with tumor stage and lymph node status. TFF3 exhibited positive correlation with age, IL-6, vitamin D, kynurenine, urinary neopterin/creatinine ratio and kynurenine/tryptophan ratio. S100-A11, as well as AIF-1 correlated positively with Il-6 and TFF3. TFF3, S100-A11 and AIF-1 represent potential biomarkers in patients with endometrial cancer. TFF3 and S100-A11 increase with tumor stage and lymph node involvement, reflecting higher tumor mass that is also associated with increased concentration of biomarkers of immune dysfunction.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"12 - 6"},"PeriodicalIF":0.4,"publicationDate":"2018-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47869452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-01DOI: 10.1515/pteridines-2018-0004
V. Groehn, G. Ramamurthy, M. Ulmann, W. Armarego
Professor emeritus, Dr. rer. nat. Dr. h.c. Wolfgang Pfleiderer was born 1927 at Esslingen am Neckar, Germany. He began his studies of chemistry at the University of Stuttgart in November, 1946. In May, 1950 he received the Diploma (Master Degree) and in January 1952 the Ph.D. degree at the University of Stuttgart under supervision of Professor Dr. H. Bredereck. The title of his thesis was: Investigations of Purines. In January, 1957, the research entitled: Investigations in the Field of Pteridines resulted in the Habilitation at the University of Stuttgart. In March, 1958 he was appointed Lecturer in Organic Chemistry at the University of Stuttgart. From May, 1958 until June, 1959 he was a Postdoctoral Research Associate at Princeton University with Professor Edward C. Taylor. In March, 1962 he received the appointment as apl. Professor at the University of Stuttgart. During the summer of 1963 he was appointed a Visiting Professor at the Arizona State University and his host was Professor Roland K. Robins. In late 1963 he was appointed German Editor of the Journal of Heterocyclic Chemistry. He was a Visiting Professor at the Australian National University in Canberra from June, 1965 until November, 1965. His host was Professor Adrien Albert. In April, 1967 he was appointed Full Professor in Organic Chemistry at the newly founded University of Konstanz. He remained in this position until retirement. During August and September, 1977 he was a visitor at the University of Osaka. His host was Professor Dr. M. Ikehara. During March, 1980 he was a Visiting Professor at the University of Baghdad, Iraq. His host was Professor Dr. M. Shanshal. He was a Visiting Professor at the University of Strathclyde in Glasgow, Scotland during October, 1980. His host was Professor Dr. H. C. S. Wood. He was elected President of the International Society of Heterocyclic Chemistry for the two year period, 1982-1983. In July, 1982 he was awarded an honorary degree Dr. h.c. by the Trinity College Dublin, Ireland. He was a Visiting Professor at the Fudan University, Shanghai, Peoples Republic of China during September and October, 1987. He was invited again by the Australian National University as Visiting Fellow in May-June 1996 with Drs Jill E. Gready and Wilf Armarego as hosts in order that he could also visit and lecture at various other centres in Australia. Despite his disability, i.e., he lost his left hand, his lower left arm, as well as several fingers of his right hand during the 2 World War, Wolfgang Pfleiderer was an extremely active researcher. He had such a remarkable personality that his disability did not deter him in any way from becoming among the best experimentalist at the bench. Up to 2016 he and his very faithful collaborator Geeta Ramamurthy spent almost all days in the chemical laboratory at the University of Konstanz still carrying out new experiments and publishing the results. He has authored >600 scientific papers and several books. His main topi
名誉教授，博士。沃尔夫冈·普莱德勒博士1927年出生于德国内卡尔的埃斯林根。1946年11月，他开始在斯图加特大学学习化学。1950年5月，他在斯图加特大学H. Bredereck教授的指导下获得硕士学位，1952年1月获得博士学位。他的论文题目是:嘌呤的研究。1957年1月，一项题为“在Pteridines领域的调查”的研究导致了斯图加特大学的康复。1958年3月，他被任命为斯图加特大学有机化学讲师。1958年5月至1959年6月，他在普林斯顿大学任博士后研究员，师从爱德华·c·泰勒教授。1962年3月，他被任命为总统。斯图加特大学教授。1963年夏天，他被任命为亚利桑那州立大学的客座教授，接待他的是罗兰·k·罗宾斯教授。1963年底，他被任命为《杂环化学杂志》的德文编辑。1965年6月至11月任堪培拉澳大利亚国立大学客座教授。他的东道主是阿德里安·阿尔伯特教授。1967年4月，他被任命为新成立的康斯坦茨大学有机化学正教授。他一直担任这个职位直到退休。1977年8月至9月期间，他访问了大阪大学。他的东道主是池原教授。1980年3月，他在伊拉克巴格达大学担任客座教授。他的东道主是M. Shanshal教授。1980年10月，他在苏格兰格拉斯哥的斯特拉斯克莱德大学担任客座教授。他的东道主是h·c·s·伍德教授。1982年至1983年，他被选为国际杂环化学学会主席。1982年7月，他被爱尔兰都柏林三一学院授予荣誉博士学位。1987年9月至10月，他在中华人民共和国上海复旦大学担任客座教授。1996年5月至6月，澳大利亚国立大学再次邀请他作为访问学者，Jill E. Gready博士和Wilf Armarego博士作为东道主，以便他也可以访问澳大利亚的其他各个中心并在那里演讲。尽管他的残疾，即他失去了左手，左臂，以及右手的几个手指在第二次世界大战期间，沃尔夫冈·普莱德勒是一个非常活跃的研究者。他有着非凡的个性，他的残疾丝毫没有妨碍他成为最优秀的实验家之一。直到2016年，他和他非常忠实的合作者吉塔·拉马穆尔蒂几乎所有的时间都在康斯坦茨大学的化学实验室里进行新的实验并发表结果。他撰写了600多篇科学论文和几本书。主要研究方向:有机化学，杂环化学，蝶啶，嘌呤，嘧啶，核酸化学，核苷，核苷酸，寡核苷酸，保护教授Dr. h.c. Wolfgang Eugen Pfleiderer *22.7.1927†20.1.2018
{"title":"Professor Wolfgang E. Pfleiderer – obituary","authors":"V. Groehn, G. Ramamurthy, M. Ulmann, W. Armarego","doi":"10.1515/pteridines-2018-0004","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0004","url":null,"abstract":"Professor emeritus, Dr. rer. nat. Dr. h.c. Wolfgang Pfleiderer was born 1927 at Esslingen am Neckar, Germany. He began his studies of chemistry at the University of Stuttgart in November, 1946. In May, 1950 he received the Diploma (Master Degree) and in January 1952 the Ph.D. degree at the University of Stuttgart under supervision of Professor Dr. H. Bredereck. The title of his thesis was: Investigations of Purines. In January, 1957, the research entitled: Investigations in the Field of Pteridines resulted in the Habilitation at the University of Stuttgart. In March, 1958 he was appointed Lecturer in Organic Chemistry at the University of Stuttgart. From May, 1958 until June, 1959 he was a Postdoctoral Research Associate at Princeton University with Professor Edward C. Taylor. In March, 1962 he received the appointment as apl. Professor at the University of Stuttgart. During the summer of 1963 he was appointed a Visiting Professor at the Arizona State University and his host was Professor Roland K. Robins. In late 1963 he was appointed German Editor of the Journal of Heterocyclic Chemistry. He was a Visiting Professor at the Australian National University in Canberra from June, 1965 until November, 1965. His host was Professor Adrien Albert. In April, 1967 he was appointed Full Professor in Organic Chemistry at the newly founded University of Konstanz. He remained in this position until retirement. During August and September, 1977 he was a visitor at the University of Osaka. His host was Professor Dr. M. Ikehara. During March, 1980 he was a Visiting Professor at the University of Baghdad, Iraq. His host was Professor Dr. M. Shanshal. He was a Visiting Professor at the University of Strathclyde in Glasgow, Scotland during October, 1980. His host was Professor Dr. H. C. S. Wood. He was elected President of the International Society of Heterocyclic Chemistry for the two year period, 1982-1983. In July, 1982 he was awarded an honorary degree Dr. h.c. by the Trinity College Dublin, Ireland. He was a Visiting Professor at the Fudan University, Shanghai, Peoples Republic of China during September and October, 1987. He was invited again by the Australian National University as Visiting Fellow in May-June 1996 with Drs Jill E. Gready and Wilf Armarego as hosts in order that he could also visit and lecture at various other centres in Australia. Despite his disability, i.e., he lost his left hand, his lower left arm, as well as several fingers of his right hand during the 2 World War, Wolfgang Pfleiderer was an extremely active researcher. He had such a remarkable personality that his disability did not deter him in any way from becoming among the best experimentalist at the bench. Up to 2016 he and his very faithful collaborator Geeta Ramamurthy spent almost all days in the chemical laboratory at the University of Konstanz still carrying out new experiments and publishing the results. He has authored >600 scientific papers and several books. His main topi","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"13 - 14"},"PeriodicalIF":0.4,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45182993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-01Epub Date: 2018-11-13DOI: 10.1515/pteridines-2018-0013
Hina Makkar, Mark A Reynolds, Abhishek Wadhawan, Aline Dagdag, Anwar T Merchant, Teodor T Postolache
Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.
{"title":"Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health.","authors":"Hina Makkar, Mark A Reynolds, Abhishek Wadhawan, Aline Dagdag, Anwar T Merchant, Teodor T Postolache","doi":"10.1515/pteridines-2018-0013","DOIUrl":"10.1515/pteridines-2018-0013","url":null,"abstract":"<p><p>Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.</p>","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"124-163"},"PeriodicalIF":0.4,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/e8/nihms-1004292.PMC6350811.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36906542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：