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Efficacy of 5-HT3 receptor antagonists (ondansetron) vs dopamine receptor antagonists (droperidol) for preventing postoperative nausea, vomiting and headache: a meta-analysis 5-HT3受体拮抗剂(昂丹司琼)与多巴胺受体拮抗剂(氟哌啶醇)预防术后恶心、呕吐和头痛的疗效:一项荟萃分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-01-01 DOI: 10.1515/pteridines-2019-0018
Xiao-yun Chen, Yinying Qin, Si-ying Li, Heshou Lei, Xiao-yun Wu, LiPei Shu
Abstract Objective To investigate the effects of 5-hydroxytryptamine 3 receptor antagonists (ondansetron [OND]) versus dopamine receptor antagonists (droperidol [DRO]) in the prevention of postoperative nausea, vomiting (PONV) and headache by pooling data from open published studies. Methods Performed systematic electronic searches of PubMed, Embase, Google scholar and CNKI, to identify open-published prospective randomized controlled trials (RCTs) relevant to the comparison of OND versus DRO for preventing PONV and headache to be included in the present study. The pooled PONV, headache, dizziness and drowsiness were calculated based on the original data of each included study. The pooled data was presented with risk ratio (RR) and 95% confidence interval (95%CI). Results Thirteen prospective randomized clinical trials were included in this meta-analysis. The pooled PONV, post-operative nausea (PON) and positive operative vomiting (POV) were 0.67 (95%CI:0.48-0.93, p<0.05), 0.88 (95%CI:0.67-1.14, p>0.05) and 0.56 (95%CI:0.39-0.82,p<0.05) respectively for OND vs. DRO. And the overall pooled positive operative nausea and vomiting was 0.71(95%CI:0.60-0.86) by fixed effects model for OND vs. DRO. The pooled risk of postoperative headache, dizziness and drowsiness were 4.33 (95%CI:0.76-24.69, p>0.05), 0.63 (95%CI:0.21-1.87, p>0.05) and 0.48(0.28-0.81,p<0.05) respectively by fixed effect model for OND vs. DRO. Conclusion The post-operative nausea, vomiting and dizziness risks were significant decreased for patients receiving OND compared to patients receiving DRO.
摘要目的通过收集公开发表的研究数据,探讨5-羟色胺3受体拮抗剂(昂丹司琼[OND])与多巴胺受体拮抗剂(氟哌啶醇[DRO])在预防术后恶心、呕吐(PONV)和头痛中的作用。方法系统检索PubMed、Embase、谷歌scholar和中国知网,筛选与口服口服吗啡与口服口服吗啡预防脑出血和头痛相关的公开发表的前瞻性随机对照试验(rct),纳入本研究。合并PONV、头痛、头晕和困倦是根据每项纳入研究的原始数据计算的。合并后的数据以风险比(RR)和95%置信区间(95% ci)表示。结果本荟萃分析纳入13项前瞻性随机临床试验。根据固定效应模型,OND与DRO的合并PONV、术后恶心(PON)和术后阳性呕吐(POV)分别为0.67 (95%CI:0.48 ~ 0.93, p0.05)、0.56 (95%CI:0.39 ~ 0.82,p0.05)、0.63 (95%CI:0.21 ~ 1.87, p<0.05)和0.48(0.28 ~ 0.81,p<0.05)。结论与DRO组相比,OND组术后恶心、呕吐和头晕风险明显降低。
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引用次数: 2
Elevated serum neopterin and homocysteine increased the risk of ischemic stroke in patients with transient ischemic attack 血清新蝶呤和同型半胱氨酸升高增加短暂性脑缺血发作患者发生缺血性脑卒中的风险
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-01-01 DOI: 10.1515/pteridines-2019-0009
Jing Xie, Xia Qiu, Chunling Ji, Chun-Hong Liu, Yueming Wu
Abstract Objective: To investigate the correlation between serum neopterin, homocysteine (Hcy) and the risk of developing ischemic stroke (IS) in patients with transient ischemic attack (TIA). Methods: Ninety-two TIA patients were prospectively recruited at the First Affiliated Hospital of the Medical College, Shihezi University, Xinjiang Autonomous Region China. Of the included patients, 27 developed ischemic stroke (IS group) and other 65 cases did not (TIA group). Peripheral venous blood was obtained within 24 hours of TIA diagnosis. Serum neopterin, Hcy and serum lipid levels were tested and compared between IS and TIA groups. Results: Serum neopterin (6.38±1.76 ng/mL vs 5.39±1.51 ng/mL), Hcy (17.95±4.10 μmol/L vs 15.30±3.66 μmol/L), TG (1.82±0.92 mmol/L vs 1.40±0.71 mmol/L) and LDL (3.31±0.67 mmol/L vs 2.69±0.62 mmol/L) of IS group were significantly higher than those of TIA group (p<0.05). The AUC of serum neopterin, Hcy, TG and LDL for predicting the risk of developing IS in patients with TIA were 0.68 (95%CI: 0.55-0.81, 0.68 (95%CI: 0.57-0.80), 0.64 (95%CI: 0.51-0.78) and 0.75 (95%CI: 0.63-0.86), respectively. Conclusion: Serum neopterin, Hcy, TG and LDL are promising serological markers for predicting the increased risk of developing IS for patients with TIA.
摘要目的:探讨短暂性脑缺血发作(TIA)患者血清新蝶呤、同型半胱氨酸(Hcy)与缺血性脑卒中(IS)发生风险的相关性。方法:在中国新疆自治区石河子大学医学院第一附属医院前瞻性招募92例TIA患者。在纳入的患者中,27例发生缺血性脑卒中(IS组),其他65例没有发生缺血性脑缺血(TIA组)。在TIA诊断后24小时内采集外周静脉血。检测IS组和TIA组的血清新蝶呤、Hcy和血脂水平并进行比较。结果:IS组血清新蝶呤(6.38±1.76 ng/mL vs 5.39±1.51 ng/mL)、Hcy(17.95±4.10μmol/L vs 15.30±3.66μmol/L)、TG(1.82±0.92 mmol/L vs 1.40±0.71 mmol/L)和LDL(3.31±0.67 mmol/L vs 2.69±0.62 mmol/L)均显著高于TIA组(p<0.05),TG和LDL预测TIA患者发展为IS的风险分别为0.68(95%CI:0.55-0.81,0.68(95%CI:0.57-0.80),0.64(95%CI=0.51-0.78)和0.75(95%CI0.63-0.86)。结论:血清新蝶呤、Hcy、TG和LDL是预测TIA患者发生IS风险增加的有前景的血清学标志物。
{"title":"Elevated serum neopterin and homocysteine increased the risk of ischemic stroke in patients with transient ischemic attack","authors":"Jing Xie, Xia Qiu, Chunling Ji, Chun-Hong Liu, Yueming Wu","doi":"10.1515/pteridines-2019-0009","DOIUrl":"https://doi.org/10.1515/pteridines-2019-0009","url":null,"abstract":"Abstract Objective: To investigate the correlation between serum neopterin, homocysteine (Hcy) and the risk of developing ischemic stroke (IS) in patients with transient ischemic attack (TIA). Methods: Ninety-two TIA patients were prospectively recruited at the First Affiliated Hospital of the Medical College, Shihezi University, Xinjiang Autonomous Region China. Of the included patients, 27 developed ischemic stroke (IS group) and other 65 cases did not (TIA group). Peripheral venous blood was obtained within 24 hours of TIA diagnosis. Serum neopterin, Hcy and serum lipid levels were tested and compared between IS and TIA groups. Results: Serum neopterin (6.38±1.76 ng/mL vs 5.39±1.51 ng/mL), Hcy (17.95±4.10 μmol/L vs 15.30±3.66 μmol/L), TG (1.82±0.92 mmol/L vs 1.40±0.71 mmol/L) and LDL (3.31±0.67 mmol/L vs 2.69±0.62 mmol/L) of IS group were significantly higher than those of TIA group (p<0.05). The AUC of serum neopterin, Hcy, TG and LDL for predicting the risk of developing IS in patients with TIA were 0.68 (95%CI: 0.55-0.81, 0.68 (95%CI: 0.57-0.80), 0.64 (95%CI: 0.51-0.78) and 0.75 (95%CI: 0.63-0.86), respectively. Conclusion: Serum neopterin, Hcy, TG and LDL are promising serological markers for predicting the increased risk of developing IS for patients with TIA.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"30 1","pages":"59 - 64"},"PeriodicalIF":0.4,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2019-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43081969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Serum Neopterin and its Significance as Biomarker in Differentiation of Mods From Sepsis 血清新蝶呤及其生物标志物在脓毒症Mods鉴别中的意义
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-12-31 DOI: 10.1515/pteridines-2018-0018
Xiaohong Zhang, Qingli Chen, Shuang Ni, Zemin Xiang, Xiaohui Zhou, Yuanyuan Huang
Abstract Objective The aim of this study was to evaluate the dynamic changes of serum neopterin and its significance as biomarker in differentiation of MODS from sepsis. Methods Fifty eight critical illness patients and 21 healthy controls were included in the study. Of the included 58 critical illness patients, 37 cases were diagnosed of sepsis (sepsis group) and other 21 were non-sepsis subjects (non-sepsis group). Of the 37 sepsis patients, 17 were diagnosed of multiple organ dysfunction syndrome (MODS group). The serum level of neopterin of the above subjects were examined by enzyme linked immunosorbent assay and compared between groups. Results The serum level of neopterin were 0.885±0.34(ng/mL), 3.77±2.08(ng/mL), 14.80±6.78(ng/mL) and 23.90±11.26(ng/mL) for healthy control, non-sepsis, non-MODS and MODS groups respectively with significant statistical difference (F=52.71, p<0.001). Serum neopterin level of non-sepsis, non-MODS and MODS groups were statistical different in the time points of 0, 24h, 48h, 72h, and 96h (p<0.05). The serum neopterin level was significant higher in MODS group compared to nonsepsis and non-MODS groups (p<0.05). Using the serum neopterin as biomarker in differentiation of MODS from sepsis, the diagnostic sensitivity, specificity and AUC were 70.59% (95%CI:44.04-89.69) %, 80.00% (95%CI:56.34- 94.27)% and 0.74(95%CI:0.57-0.91)% respectively. Conclusion Serum neopterin levels in patients with sepsis were elevated and can be used as a promising biomarker in differentiation of MODS from sepsis.
摘要目的探讨血清新蝶呤的动态变化及其作为MODS与败血症鉴别诊断生物标志物的意义。方法对58例危重症患者和21例健康对照进行研究。在纳入的58名危重症患者中,37例被诊断为败血症(败血症组),其他21例为非败血症受试者(非败血症组)。在37例败血症患者中,17例被诊断为多器官功能障碍综合征(MODS组)。采用酶联免疫吸附法检测上述受试者的血清新蝶呤水平,并在各组之间进行比较。结果健康对照组、非脓毒症组、非MODS组和MODS组血清新蝶呤水平分别为0.885±0.34(ng/mL)、3.77±2.08(ng/mL,以血清新蝶呤作为MODS与脓毒症鉴别的生物标志物,其诊断敏感性、特异性和AUC分别为70.59%(95%CI:44.04-89.69)%、80.00%(95%CI:56.34-94.27)%和0.74(95%CI:0.57-0.91)%。结论脓毒症患者血清新蝶呤水平升高,可作为鉴别MODS与脓毒症的一种有前景的生物标志物。
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引用次数: 2
The predictive value of serum neopterin for multiple organ dysfunction syndrome in severe burn patients 血清新蝶呤对严重烧伤患者多器官功能障碍综合征的预测价值
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-12-31 DOI: 10.1515/pteridines-2018-0019
W. Xiong, J. Ouyang, Hai Ci, Wenping Jiang, W. Han, Yu Fu, Peigang Tian
Abstract Objective To investigate the predictive value of serum neopterin for multiple organ dysfunction syndrome (MODS) in severe burn patients. Methods Seventy-six severe burn patients with burns covering a total body surface area (TBSA) above 70% were included in this study. Of the 76 patients, 29 cases developed MODS (MODS group) and the remaining 47 subjects did not (non-MODS group). From the MODS group, 12 patients died (Death group) and 17 patients survived (Survive group). The serum level of neopterin in the MODS and non-MODS groups were examined by radioimmunoassay on following 1, 3 , 7 , 14 , 21 and 28 post-burn days (PBDs). A receiver operating characteristic (ROC) curve was used to analyse the predictive value of serum neopterin for MODS and death. Results The serum neopterin level in the MODS group was significantly higher than that of non-MODS group between 3~28 PBDs (p<0.001). However, the serum neopterin levels between the MODS and non-MODS groups following 1 PBD were not statistically significant (p>0.05). The best diagnostic performance of serum neopterin for MODS occurred 14 PBDs with the prediction sensitivity and specificity of 75.86% (56.46%~89.70%) and 85.11% (71.69%~93.80%) respectively. However, serum neopterin levels had no clinical value in predicting the death of MODS patients. The area under the ROC curve (AUC) was 0.72 (0.58~0.85), 0.81 (0.71~0.92) and 0.83 (0.72~0.94) for serum neopterin as biomarker in the prediction of MODS after 3, 7 and 14 PBDs, respectively. The AUCs were 0.50 (0.27~0.73), 0.53 (0.30~0.76) and 0.56 (0.33~0.79) for serum neopterin as biomarker in prediction of death for MODS patients after 3, 7 and 14 PBDs, respectively. Conclusion The persistent and significant increase of serum neopterin level is closely related to the development of MODS in patients with severe burns. Serum neopterin is therefore a promising serological marker for MODS early diagnosis, but has little efficacy in the prediction of the likelihood of death in severe burn patients with MODS.
摘要目的探讨血清新蝶呤对严重烧伤患者多器官功能障碍综合征(MODS)的预测价值。方法对76例全身表面积(TBSA)大于70%的严重烧伤患者进行研究。76例患者中,29例发生MODS(MODS组),其余47例未发生MODS。MODS组死亡12例(死亡组),存活17例(存活组)。采用放射免疫分析法分别于烧伤后第1、3、7、14、21和28天(PBDs)检测MODS组和非MODS组血清新蝶呤水平。采用受试者工作特性(ROC)曲线分析血清新蝶呤对MODS和死亡的预测价值。结果MODS组血清新蝶呤水平在3~28个PBD之间明显高于非MODS组(p0.05),血清新蝶啶对MODS的最佳诊断表现为14个PBD,其预测敏感性和特异性分别为75.86%(56.46%~89.70%)和85.11%(71.69%~93.80%)。然而,血清新蝶呤水平在预测MODS患者死亡方面没有临床价值。血清新蝶呤作为生物标志物预测3、7和14个PBD后MODS的ROC曲线下面积(AUC)分别为0.72(0.58~0.85)、0.81(0.71~0.92)和0.83(0.72~0.94)。血清新蝶呤作为生物标志物预测MODS患者3、7和14个PBD后死亡的AUC分别为0.50(0.27~0.73)、0.53(0.30~0.76)和0.56(0.33~0.79)。结论严重烧伤患者血清新蝶呤水平持续显著升高与MODS的发生密切相关。因此,血清新蝶呤是一种很有前途的MODS早期诊断血清学标志物,但在预测严重烧伤MODS患者的死亡可能性方面收效甚微。
{"title":"The predictive value of serum neopterin for multiple organ dysfunction syndrome in severe burn patients","authors":"W. Xiong, J. Ouyang, Hai Ci, Wenping Jiang, W. Han, Yu Fu, Peigang Tian","doi":"10.1515/pteridines-2018-0019","DOIUrl":"https://doi.org/10.1515/pteridines-2018-0019","url":null,"abstract":"Abstract Objective To investigate the predictive value of serum neopterin for multiple organ dysfunction syndrome (MODS) in severe burn patients. Methods Seventy-six severe burn patients with burns covering a total body surface area (TBSA) above 70% were included in this study. Of the 76 patients, 29 cases developed MODS (MODS group) and the remaining 47 subjects did not (non-MODS group). From the MODS group, 12 patients died (Death group) and 17 patients survived (Survive group). The serum level of neopterin in the MODS and non-MODS groups were examined by radioimmunoassay on following 1, 3 , 7 , 14 , 21 and 28 post-burn days (PBDs). A receiver operating characteristic (ROC) curve was used to analyse the predictive value of serum neopterin for MODS and death. Results The serum neopterin level in the MODS group was significantly higher than that of non-MODS group between 3~28 PBDs (p<0.001). However, the serum neopterin levels between the MODS and non-MODS groups following 1 PBD were not statistically significant (p>0.05). The best diagnostic performance of serum neopterin for MODS occurred 14 PBDs with the prediction sensitivity and specificity of 75.86% (56.46%~89.70%) and 85.11% (71.69%~93.80%) respectively. However, serum neopterin levels had no clinical value in predicting the death of MODS patients. The area under the ROC curve (AUC) was 0.72 (0.58~0.85), 0.81 (0.71~0.92) and 0.83 (0.72~0.94) for serum neopterin as biomarker in the prediction of MODS after 3, 7 and 14 PBDs, respectively. The AUCs were 0.50 (0.27~0.73), 0.53 (0.30~0.76) and 0.56 (0.33~0.79) for serum neopterin as biomarker in prediction of death for MODS patients after 3, 7 and 14 PBDs, respectively. Conclusion The persistent and significant increase of serum neopterin level is closely related to the development of MODS in patients with severe burns. Serum neopterin is therefore a promising serological marker for MODS early diagnosis, but has little efficacy in the prediction of the likelihood of death in severe burn patients with MODS.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"29 1","pages":"196 - 200"},"PeriodicalIF":0.4,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2018-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44257685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Inflammatory Bowel Disease Etiology: Current Knowledge 炎症性肠病的病因学:目前的知识
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-12-31 DOI: 10.1515/pteridines-2018-0020
Justyna Kikut, Nina Konecka, Maciej Ziętek, M. Szczuko
Abstract Non-specific inflammatory bowel diseases (IBD) include Crohn’s disease (CD) and ulcerative colitis (UC). Both diseases are characterized by chronic inflammation of unclear etiology. The inflammatory bowel diseases incidence is continuously observed to rise. Colon inflammatory response is a physiological process which occurrence is indispensable as an organisms’ defense reaction. The inflammation may be caused by internal factors associated with body’s cells as well as external factors, such as infections and exposition for inflammatory agents. Until recently, IBD have been classified as autoimmune diseases, today they seem to be associated with gut barrier disorders or dysbiosis. Factors that predispose to inflammatory bowel diseases include: genetic factors, dysbiosis and so called western-type diet, natural components such as gluten and lactose. In addition, the development of the disease is favored by: cigarette smoking, phosphate, nanomolecules, sodium chloride, emulgents, carrageenan, carboxymethylcellulose, pollution, maltodextrin. IBD affects whole the body, causing serious medical consequences. Symptoms like anxiety and chronic stress, that occur commonly, can lead to depressive disorders. Quantitative and qualitative dietary deficiency caused by absorption disorders, may promote the occurrence of osteoporosis and osteopenia. In addition, dysbiosis coexisting with alterations in intestinal permeability can lead to the development of nonalcoholic fatty liver disease. IBD medical consequences include also systemic complications, associated with the extra gastrointestinal manifestations’ occurrence.
摘要非特异性炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC)。这两种疾病都以病因不明的慢性炎症为特征。炎症性肠病的发病率持续上升。结肠炎症反应是一个生理过程,作为生物体的防御反应,它的发生是必不可少的。炎症可能是由与身体细胞相关的内部因素以及外部因素引起的,如感染和炎症因子的暴露。直到最近,IBD一直被归类为自身免疫性疾病,如今它们似乎与肠道屏障紊乱或微生态失调有关。易患炎症性肠病的因素包括:遗传因素、生态失调和所谓的西方饮食、面筋和乳糖等天然成分。此外,该疾病的发展受到以下因素的青睐:吸烟、磷酸盐、纳米分子、氯化钠、乳化剂、卡拉胶、羧甲基纤维素、污染、麦芽糊精。IBD影响全身,造成严重的医疗后果。常见的焦虑和慢性压力等症状会导致抑郁障碍。由吸收障碍引起的定量和定性膳食缺乏,可能促进骨质疏松和骨质减少的发生。此外,微生态失调与肠道通透性改变共存可导致非酒精性脂肪肝的发展。IBD的医疗后果还包括与胃肠外表现的发生相关的全身并发症。
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引用次数: 10
Occurrence and significance of folic acid 叶酸的发生及其意义
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-12-31 DOI: 10.1515/pteridines-2018-0017
E. Cieślik, I. Cieslik
Abstract Folic acid is a naturally occurring pteridine, which was originally isolated from plants. Folic acid (pteroyl-glutamic acid) is composed of pteridine (6-methylptero), p-aminobenzoic acid (PABA) and glutamic acid. Folic acid (folacin) is a compound of major importance for the proper functioning of the human body. Its adequate supply is essential for the proper course of many biochemical processes in the body, including the process of neural tube closure in the fetus, DNA and amino acid synthesis, growth of red blood cells, and the function of the nervous system. Folic acid is a compound of a high sensitivity to physical and chemical factors, and its bioavailability is limited by interactions with multiple food components. Therefore, folate deficiency is one of the most common deficiencies. This paper presents the structure and characteristics of folic acid as a pteridine, it also discusses dietary sources of folate and the effects of its deficiency.
摘要叶酸是一种天然存在的蝶呤,最初是从植物中分离出来的。叶酸(蝶酰基谷氨酸)由蝶呤(6-甲基蝶呤)、对氨基苯甲酸(PABA)和谷氨酸组成。叶酸(folacin)是一种对人体正常功能至关重要的化合物。它的充足供应对身体许多生化过程的正常进行至关重要,包括胎儿神经管闭合过程、DNA和氨基酸合成、红细胞生长和神经系统功能。叶酸是一种对物理和化学因素高度敏感的化合物,其生物利用度受到多种食物成分相互作用的限制。因此,叶酸缺乏症是最常见的缺乏症之一。本文介绍了叶酸作为一种蝶呤的结构和特性,并讨论了叶酸的膳食来源及其缺乏的影响。
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引用次数: 5
Serum folic acid, PCT, CRP and ESR detection as biomarker in differentiation ulcerative colitis activity 血清叶酸、PCT、CRP和ESR检测作为鉴别溃疡性结肠炎活动性的生物标志物
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-12-01 DOI: 10.1515/pteridines-2018-0016
D. Xia, Jikun An
Abstract Objective: To investigate the serum concentration of folic acid, procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as biomarkers in the differentiation of the severity of ulcerative colitis (UC). Methods: Fifty one patients who had been diagnosed with UC were recruited from January 2014 to August 2017. Twenty-two of these patients had severe diseases while the remaining twenty-nine patients had mild/moderate disease, according to the Truelove-Witts classification criteria. In the same study, 26 healthy subjects which served as the healthy controls were included alongside the UC patient group. The serum folic acid, PCT, CRP and ESR were examined and compared among the healthy control, mild/moderate and severe UC groups. Results: The serum PCT, CRP and ESR in the control group were significantly lower than those of mild/moderate and severe UC groups with statistical significance (p<0.001). However, the serum folic acid in the control group was significant higher than that of mild/ moderate and severe UC groups (p<0.001). The serum folic acid (p=0.015), PCT (p<0.001) and ESR (p<0.001) were significantly different between the severe and mild/moderate groups. However, the serum CRP was not statistically significant between the mild/moderate and severe UC groups (p=0.06). Using serum folic acid, PCT, CRP and ESR as biomarkers in the differentiation of mild/moderate and severe UC, the serum PCT had good diagnostic accuracy for detecting severe UC with the diagnostic sensitivity and specificity of 85.71% (63.66~96.95%), 82.76% (64.23~94.15%), respectively under the cut off value of 0.045. The correlation between serum CRP, ESR and PCT were examined by Pearson correlation test and line regression analysis. However, there was no correlation between each of them with the exception of folic acid and ESR (r=-0.334, p=0.017). Conclusion: Serum folic acid, PCT, CRP and ESR are significantly elevated in patients with active UC thereby presenting novel and potentially promising biomarkers for the diagnosis and differentiation of mild/moderate and sever UC.
摘要目的:探讨血清叶酸、降钙素原(PCT)、c反应蛋白(CRP)和红细胞沉降率(ESR)作为溃疡性结肠炎(UC)严重程度鉴别的生物标志物。方法:从2014年1月至2017年8月招募51例被诊断为UC的患者。根据Truelove-Witts分类标准,这些患者中有22人患有严重疾病,而其余29人患有轻度/中度疾病。在同一项研究中,26名健康受试者与UC患者组一起作为健康对照。比较健康对照组、轻/中度和重度UC组患者血清叶酸、PCT、CRP和ESR水平。结果:对照组患者血清PCT、CRP、ESR均显著低于轻/中、重度UC组,差异均有统计学意义(p<0.001)。对照组血清叶酸水平显著高于轻/中度和重度UC组(p<0.001)。血清叶酸(p=0.015)、PCT (p<0.001)和ESR (p<0.001)在重度组和轻度/中度组之间差异有统计学意义。然而,血清CRP在轻度/中度和重度UC组之间无统计学意义(p=0.06)。将血清叶酸、PCT、CRP和ESR作为鉴别轻/中、重度UC的生物标志物,在截断值为0.045下,血清PCT对重度UC的诊断准确率较高,诊断敏感性和特异性分别为85.71%(63.66~96.95%)和82.76%(64.23~94.15%)。采用Pearson相关检验和线性回归分析血清CRP、ESR和PCT的相关性。然而,除了叶酸与ESR外,其余三者之间均无相关性(r=-0.334, p=0.017)。结论:活动性UC患者血清叶酸、PCT、CRP和ESR显著升高,为轻/中度和重度UC的诊断和鉴别提供了新的、有潜力的生物标志物。
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引用次数: 5
Elevated ESRS, serum FIB, Hcy and stroke history were independent risk factors to PAIS ESRS、FIB、Hcy和卒中史升高是PAIS的独立危险因素
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-11-01 DOI: 10.1515/pteridines-2018-0014
Tao Zhang, Huiyun Li, Ling Li, Faying Zhou
Abstract Background: The aim of this study was to investigate the diagnostic performance of serum homocysteine (Hcy) and Essen stroke risk score (ESRS) in prediction of progressing acute ischemic stroke (PAIS). Methods One hundred and thirty two acute ischemic stroke (AIS) patients were retrospectively recruited from Daping Hospital, Third Military Medical University from February 2016 to January 2018. The 132 AIS patients were divided into PAIS and non-progressing AIS (NPAIS) groups according to the definition of PAIS. The clinical characteristics, serum Hcy concentration, and ESRS were compared between the PAIS and NPAIS groups. The independent risk factors for PAIS were evaluated by logistic regression analysis. The prediction sensitivity, specificity and area under the ROC curve (AUC) of serum Hcy and ESRS for PAIS were calculated using STATA11.0 software. Results: The elevated ESRS (OR=1.82, p<0.05), serum fibrinogen (FIB) (OR=1.18, p<0.05), Hcy (OR=1.21, p<0.05) and personal stroke history (OR=1.74, p<0.05) were independent risk factors for PAIS. The serum Hcy of the PAIS and NPAIS groups were 24.59±9.24 (μmol/L) and 18.20±8.29 (μmol/L) respectively with a statistical significance of p<0.05. The ESRS were 3.43±1.09 and 2.60±0.92 for the PAIS and NPAIS groups respectively, with a significance of p<0.05. The prediction sensitivity, specificity and AUC were 76.24%, 67.74% and 0.73 (95%CI:0.63-0.83), respectively, for serum Hcy. For ESRS, the prediction sensitivity, specificity and AUC were 69.99%, 64.52% and 0.74 (95%CI:0.63-0.84) respectively. Correlation between serum Hcy and ESRS was evaluated by a Pearson correlation test. Significant positive correlation between serum Hcy and ESRS was found in PAIS (r=0.54, p<0.05), and NPAIS patients (r=0.78, p<0.01). Conclusion: Patients with elevated ESRS, serum FIB, Hcy and stroke history had an elevated risk of developing PAIS.
背景:本研究旨在探讨血清同型半胱氨酸(Hcy)和Essen卒中风险评分(ESRS)在预测进展性急性缺血性卒中(PAIS)中的诊断作用。方法回顾性收集2016年2月~ 2018年1月第三军医大学大坪医院急性缺血性脑卒中(AIS)患者132例。将132例AIS患者按照PAIS的定义分为PAIS组和非进展性AIS (NPAIS)组。比较PAIS组和NPAIS组的临床特征、血清Hcy浓度和ESRS。采用logistic回归分析评价PAIS的独立危险因素。采用STATA11.0软件计算血清Hcy和ESRS对PAIS的预测敏感性、特异性和ROC曲线下面积(AUC)。结果:ESRS升高(OR=1.82, p<0.05)、血清纤维蛋白原(FIB)升高(OR=1.18, p<0.05)、Hcy升高(OR=1.21, p<0.05)、个人卒中史升高(OR=1.74, p<0.05)是PAIS的独立危险因素。PAIS组和NPAIS组血清Hcy分别为24.59±9.24 (μmol/L)和18.20±8.29 (μmol/L),差异均有统计学意义(p<0.05)。PAIS组和NPAIS组的ESRS分别为3.43±1.09和2.60±0.92,差异均有统计学意义(p<0.05)。预测血清Hcy的敏感性为76.24%,特异性为67.74%,AUC为0.73 (95%CI:0.63 ~ 0.83)。ESRS的预测敏感性为69.99%,特异性为64.52%,AUC为0.74 (95%CI:0.63-0.84)。采用Pearson相关检验评价血清Hcy与ESRS的相关性。PAIS患者血清Hcy与ESRS呈显著正相关(r=0.54, p<0.05), NPAIS患者血清Hcy与ESRS呈显著正相关(r=0.78, p<0.01)。结论:ESRS、血清FIB、Hcy和卒中史升高的患者发生PAIS的风险增高。
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引用次数: 2
Serum of coronary atherosclerotic heart disease patients induces oxidative stress injury on endothelial cells 冠状动脉粥样硬化性心脏病患者血清诱导内皮细胞氧化应激损伤
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-10-01 DOI: 10.1515/pteridines-2018-0009
Huichao Pan, Min Zhang
Abstract Endothelial cell (EC) dysfunction has a fundamental role in the development of atherosclerosis, which leads to myocardial infarction and stroke. The aim of this study is to investigate the effect of serum from patients with coronary atherosclerotic heart disease (CAD) on endothelial cells and investigate the possible mechanism underlying these effects. Serum from 35 patients with CAD and 35 healthy volunteers was collected. Human umbilical vein endothelial cell (HUVEC) proliferation and apoptosis were assessed by a CCK‑8 assay and a flow cytometry assay, respectively. The synthesis of nitric oxide (NO) and reactive oxygen species (ROS) was measured using the nitrate reduction method and DCFH2-DA staining, respectively. The proliferation of HUVECs was inhibited by treatment with serum from CAD patients (P<0.05). Suppression of HUVEC proliferation by CAD serum occurred in a concentration-dependent manner. The synthesis of NO was also reduced in the CAD serum-treated group. Furthermore, the serum from CAD patients increased both apoptosis and intracellular ROS production in HUVECs. Moreover, treatment with tempol antagonized CAD serum-meditated HUVEC injuries. Taken together, these results suggest that HUVEC injury via CAD serum treatment is mediated by ROS production. Tempol may partly reverse this effect by abolishing HUVEC apoptosis.
内皮细胞(EC)功能障碍在动脉粥样硬化的发展中起着重要作用,动脉粥样硬化可导致心肌梗死和脑卒中。本研究的目的是探讨冠状动脉粥样硬化性心脏病(CAD)患者血清对内皮细胞的影响,并探讨这些影响的可能机制。收集了35例冠心病患者和35名健康志愿者的血清。采用CCK‑8法和流式细胞术分别评估人脐静脉内皮细胞(HUVEC)的增殖和凋亡。采用硝酸还原法和DCFH2-DA染色分别测定一氧化氮(NO)和活性氧(ROS)的合成。CAD患者血清对HUVECs增殖有抑制作用(P<0.05)。CAD血清对HUVEC增殖的抑制呈浓度依赖性。CAD血清处理组一氧化氮合成也减少。此外,CAD患者的血清增加了HUVECs的凋亡和细胞内ROS的产生。此外,用抗CAD血清治疗HUVEC损伤。综上所述,这些结果表明,通过CAD血清处理HUVEC损伤是由ROS产生介导的。Tempol可能通过消除HUVEC细胞凋亡而部分逆转这种作用。
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引用次数: 1
Perioperative Mortality Prediction Using Possum in Patients with Gastrointestinal Tumors: Do Immunological Variables Affect Individual Predictive Mortality Risk? 用负鼠预测胃肠道肿瘤患者围手术期死亡率:免疫变量影响个体预测死亡率风险吗?
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2018-10-01 DOI: 10.1515/pteridines-2018-0012
A. Engin, A. Engin, O. Kurukahvecioglu, A. Sepici‐Dinçel
Abstract The aim of this study was to evaluate whether the addition of immunological variables to the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) scoring system improves the predictability of postoperative mortality. One hundred and thirty-two consecutive patients who underwent moderate, major or major-plus elective surgical interventions for gastrointestinal tumors were scored using the POSSUM mortality risk analysis. Patients were placed in one of the two groups based on their POSSUM mortality rates which were either lower or higher than 5%. An additional 26 pre-operative and post-operative metabolic and immunological variables were measured and mortality-dependent variables were selected. Regression analysis with backward elimination of twelve pre-operative and post-operative variables correlating with POSSUM score revealed that post-operative neopterin, IL-6 and albumin were significantly dependent on the predicted mortality rates. According to these selected variables, the number of patients with a POSSUM predicted mortality rate higher than 5% increased from 64 to 88, but the percentage of the mean mortality decreased. Statistical differences between the original POSSUM and modified scoring system was highly significant (p<0.0001). The sensitivity and specificity of the modified scoring system was calculated to be 52.9% and 87.5%, respectively.
摘要本研究的目的是评估在死亡率和发病率增加的生理和手术严重程度评分(POSSUM)评分系统中添加免疫变量是否能提高术后死亡率的可预测性。使用POSSUM死亡率风险分析对132名连续接受中度、重度或重度加选择性胃肠道肿瘤手术干预的患者进行评分。根据POSSUM死亡率低于或高于5%,将患者分为两组中的一组。另外测量了26个术前和术后代谢和免疫变量,并选择了死亡率相关变量。对12个与POSSUM评分相关的术前和术后变量进行后向消除的回归分析显示,术后新蝶呤、IL-6和白蛋白显著依赖于预测的死亡率。根据这些选定的变量,POSSUM预测死亡率高于5%的患者人数从64人增加到88人,但平均死亡率的百分比有所下降。原始POSSUM和改良评分系统之间的统计学差异非常显著(p<0.0001)。改良评分系统的敏感性和特异性分别为52.9%和87.5%。
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引用次数: 0
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Pteridines
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