Psychiatry Research最新文献_第10页

Categories, symptom characteristics and factors influencing depression and anxiety in pregnant women: latent profile analysis and network analysis 孕妇抑郁、焦虑的类别、症状特征及影响因素：潜在剖面分析与网络分析

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.psychres.2025.116912

Haiyan Liu , Youjing Kong , Xiuyun Cao , Jingjing Liu , Rufang Zhou , Qianzhi Lin , Wenting Liu , Yu Chen

Comorbid prenatal depression and anxiety are prevalent among pregnant women and pose significant risks to maternal and infant health. Previous research has focused on linear associations between depression and anxiety among pregnant women, with limited exploration of subgroup characteristics and symptom heterogeneity. This study examines the categories, symptom characteristics and factors influencing depression and anxiety in pregnant women via latent profile analysis and network analysis. A cross-sectional survey was conducted from June 2021 to August 2023 at hospital obstetric clinics in Guangzhou and Zhongshan, Guangdong Province. A total of 1683 pregnant women completed the Edinburgh Postpartum Depression Scale, the seven-item Generalized Anxiety Disorder Scale, the Cognitive Fusion Questionnaire-Fusion, the Simplified Coping Style Questionnaire and the General Function of Family Assessment Device. Subgroups of patients with depression and anxiety symptoms were identified through latent profile analysis. Multiple regression and network analyses were used to reveal subgroup characteristics. The participants were divided into three subgroups: low depression and anxiety symptom groups (n = 809, 48.07%), medium depression and anxiety symptom groups (n = 756, 44.92%), and high depression and anxiety symptom groups (n = 118, 7.01%). There were significant differences among these three subgroups in terms of age, positive coping, negative coping, cognitive fusion, and family function. The core symptoms of the low and moderate depression and anxiety symptom groups were "sad or miserable" and "anxious or worried", whereas those of the high depression and anxiety symptom group were "crying" and "uncontrollable worry". Our study highlights the need for stratified interventions tailored to symptom severity and subgroup characteristics.

产前抑郁和焦虑的合并症在孕妇中普遍存在，对母婴健康构成重大风险。先前的研究主要集中在孕妇抑郁和焦虑之间的线性关系，对亚组特征和症状异质性的探索有限。本研究通过潜在特征分析和网络分析，探讨孕妇抑郁、焦虑的类别、症状特征及影响因素。横断面调查于2021年6月至2023年8月在广东省广州和中山市的医院产科诊所进行。1683名孕妇完成了爱丁堡产后抑郁量表、七项广泛性焦虑障碍量表、认知融合问卷-融合、简化应对方式问卷和家庭评估装置的一般功能。通过潜在特征分析确定抑郁和焦虑症状患者的亚组。采用多元回归和网络分析揭示亚群特征。将受试者分为低抑郁焦虑症状组（809人，48.07%）、中度抑郁焦虑症状组（756人，44.92%）、高抑郁焦虑症状组（118人，7.01%）3个亚组。三个亚组在年龄、积极应对、消极应对、认知融合、家庭功能等方面存在显著差异。低、中度抑郁焦虑症状组的核心症状为“悲伤或痛苦”和“焦虑或担心”，高抑郁焦虑症状组的核心症状为“哭泣”和“无法控制的担忧”。我们的研究强调了针对症状严重程度和亚组特征进行分层干预的必要性。

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引用次数: 0

Disconnection from care among adolescents with psychotic experiences 有精神病经历的青少年与护理的脱节

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.psychres.2025.116886

Nicole R. DeTore , Kendall B. Roberts , Jasmeen Kaur , Randi M. Schuster

Introduction

To better understand preventative service connection, this study describes the proportion of adolescents with psychotic experiences, a known transdiagnostic risk factor, who have spoken with healthcare providers about their mental health in the past year.

Method

A brief mental health survey was administered to 38,569 students across 28 middle and 38 high schools in Massachusetts in the years 2020–2022. The 13,458 middle school students had a mean age of 12, 47 % were biologically male, 59 % were White, and 23 % were Hispanic/Latino. The 25,111 high school students had a mean age of 16, 46 % were biologically male, 71 % were White, and 16 % were Hispanic/Latino. Seven psychotic experiences were assessed along with one question asking whether the student had spoken with any health provider in the past year about their emotional wellbeing.

Results

Across the three years, 27 % of middle school students, and 16 % of high school students endorsed at least one psychotic experience. Only 34 % of middle school students and 23 % of high school students with a psychotic experience had spoken with a provider in the past year about their mental health. Males and middle school students with psychotic experiences were significantly less likely to speak with a provider across all three years than females and high school students (ps<0.01).

Conclusions

These findings further highlight the need for improved mental health education for adolescents, family members, and educators, including specific information about psychiatric risk factors and pathways to mental health support for young people to encourage more help-seeking behaviors.

为了更好地了解预防性服务的联系，本研究描述了有精神病经历的青少年的比例，这是一种已知的跨诊断风险因素，他们在过去一年中与卫生保健提供者谈论过他们的精神健康。方法在2020-2022年间，对马萨诸塞州28所初中和38所高中的38569名学生进行了一项简短的心理健康调查。13458名中学生平均年龄为12岁，47%为生理上的男性，59%为白人，23%为西班牙裔/拉丁裔。25111名高中学生的平均年龄为16岁，46%为生理上的男性，71%为白人，16%为西班牙裔/拉丁裔。研究人员对七次精神病经历进行了评估，并提出了一个问题，询问学生在过去一年中是否与任何健康提供者谈论过他们的情绪健康。结果在三年中，27%的中学生和16%的高中生承认至少有一次精神病经历。在过去的一年里，只有34%的初中生和23%的有精神病经历的高中生与心理医生谈论过他们的心理健康问题。在所有三年中，有精神病经历的男性和中学生与医疗服务提供者交谈的可能性明显低于女性和高中生（ps<0.01）。结论这些发现进一步强调了加强青少年、家庭成员和教育工作者的心理健康教育的必要性，包括关于精神危险因素和青少年心理健康支持途径的具体信息，以鼓励更多的寻求帮助的行为。

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引用次数: 0

Cross-sectional analysis of ongoing clinical trials involving lamotrigine for mental disorders: Insights from ClinicalTrials.gov and the EU clinical trials 正在进行的涉及拉莫三嗪治疗精神障碍的临床试验的横断面分析：来自ClinicalTrials.gov和EU临床试验的见解。

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.psychres.2025.116878

Damian Swieczkowski , Aleksander Kwaśny , Wiesław Jerzy Cubała

This study aims to evaluate whether ongoing clinical trials address existing knowledge gaps regarding the safety and efficacy of lamotrigine, which is widely used in psychiatry, including off-label, for the treatment of various mental disorders. A cross-sectional analysis was conducted using ClinicalTrials.gov and EU Clinical Trials (with a cut-off date of March 1, 2025) to identify interventional trials involving lamotrigine for disorders classified under DSM-5/ICD-11. Filters for study type and recruitment status were applied, and eligible records were manually reviewed. A supplementary search (cut-off July 4, 2025) screened observational studies. Nine records were identified, of which five ongoing interventional trials met the inclusion criteria; all involved bipolar disorder. Although one trial also enrolled participants with schizophrenia and major depressive disorder, lamotrigine was used only in the bipolar depression arm. NCT06184581 is a phase IV RCT comparing lamotrigine and lithium in bipolar II disorder. NCT04230421 investigates smartphone mood tracking in bipolar patients. NCT04229875 examines the Clinical Academic Group model for bipolar disorder, focusing on hospitalization risk and psychosocial outcomes. NCT05603104 and NCT05973786 examine early intensified pharmacotherapy versus usual care in bipolar depression, measuring MADRS scores, and adverse events. All identified trials were non-commercials. Supplementary screening found six observational studies, mainly addressing epilepsy or pharmacokinetics, which partially address the gaps in knowledge regarding safety during pregnancy and cardiac risk. Other indications and safety aspects, including pregnancy and cardiac risk, remain under-researched. Despite widespread clinical use, further studies are needed to support evidence-based practice.

这项研究旨在评估正在进行的临床试验是否解决了关于拉莫三嗪的安全性和有效性的现有知识空白，拉莫三嗪广泛用于精神病学，包括标签外，用于治疗各种精神障碍。使用ClinicalTrials.gov和EU ClinicalTrials（截止日期为2025年3月1日）进行了横断面分析，以确定涉及拉莫三嗪治疗DSM-5/ICD-11分类疾病的干预性试验。应用研究类型和招募状态的过滤器，并手动审查符合条件的记录。一项补充研究（截止日期为2025年7月4日）筛选了观察性研究。确定了9项记录，其中5项正在进行的干预性试验符合纳入标准；都与双相情感障碍有关。尽管一项试验也招募了精神分裂症和重度抑郁症患者，但拉莫三嗪仅用于双相抑郁症组。NCT06184581是一项比较拉莫三嗪和锂治疗双相II型障碍的IV期随机对照试验。NCT04230421调查双相情感障碍患者的智能手机情绪跟踪。NCT04229875检查双相情感障碍的临床学术小组模型，重点是住院风险和心理社会结果。NCT05603104和NCT05973786研究了双相抑郁症早期强化药物治疗与常规护理的对比，测量了MADRS评分和不良事件。所有确定的试验都是非商业性的。补充筛查发现了6项观察性研究，主要涉及癫痫或药代动力学，部分解决了有关妊娠期安全性和心脏风险的知识空白。其他适应症和安全方面，包括怀孕和心脏风险，仍未得到充分研究。尽管临床应用广泛，但需要进一步的研究来支持循证实践。

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引用次数: 0

Facial expression recognition in older adults with depression: a meta-analytic review 老年抑郁症患者的面部表情识别：一项荟萃分析综述。

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.psychres.2025.116889

Paulo José Ramos Hospodar, Marcela Lima Nogueira, Tatiana Belfort, Marcia Cristina Nascimento Dourado

Objective

This study investigates facial expression recognition accuracy in older adults with Major Depressive Disorder (MDD) versus healthy older adults focusing on differences in recognizing basic emotions: sadness, happiness, surprise, fear, disgust, and anger.

Methods

This meta-analysis reviews nine studies involving 414 participants with MDD and 487 healthy controls, exploring moderators like emotion type, symptom severity, patient status, diagnostic method, stimulus type, duration, and incongruent recognitions.

Results

Older adults with depressive symptoms showed reduced recognition of happiness, sadness, and disgust compared with healthy controls, while recognition of fear and anger did not differ significantly. Sensitivity analyses indicated that heterogeneity in happiness, sadness, and disgust recognition was driven by a few influential studies, and meta-regression revealed that methodological differences influenced outcomes.

Conclusion

Older adults with depressive symptoms show selective impairments in recognizing positive and negative facial expressions, while recognition of fear and anger appears preserved. These findings highlight the need to consider methodological differences in assessing emotion recognition and may inform interventions targeting socio-emotional functioning in late-life depression.

目的：研究重度抑郁障碍（MDD）老年人与健康老年人面部表情识别准确率的差异，重点研究识别基本情绪的差异：悲伤、快乐、惊讶、恐惧、厌恶和愤怒。方法：本荟萃分析回顾了涉及414名重度抑郁症患者和487名健康对照者的9项研究，探讨情绪类型、症状严重程度、患者状态、诊断方法、刺激类型、持续时间和不一致认知等调节因素。结果：与健康对照组相比，有抑郁症状的老年人对快乐、悲伤和厌恶的识别能力降低，而对恐惧和愤怒的识别能力没有显著差异。敏感性分析表明，快乐、悲伤和厌恶识别的异质性是由少数有影响力的研究驱动的，元回归显示方法差异影响结果。结论：有抑郁症状的老年人在识别积极和消极面部表情方面表现出选择性障碍，而对恐惧和愤怒的识别则保持不变。这些发现强调了在评估情绪识别时考虑方法差异的必要性，并可能为针对老年抑郁症的社会情绪功能的干预提供信息。

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引用次数: 0

12-Month mirror study on the effectiveness and safety of six-month paliperidone palmitate in patients with schizophrenia: A Multicenter Andalusian Cohort (PAPSEM study) 6个月棕榈酸帕利哌酮治疗精神分裂症患者有效性和安全性的12个月镜像研究：一项多中心安达卢西亚队列研究

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-12 DOI: 10.1016/j.psychres.2025.116903

Jesús García-Jiménez , Óscar Lafuente-Casanova , Rosario Salas , Carlota Rodríguez , Miguel Graciani-Pérez , Pablo Roque Leonardo-Caserta , Manuel López-Arroyo , Asunta Torres-Laborde , Luis Gutiérrez-Rojas

Background

Paliperidone palmitate 6-month formulation (PP6M) offers a promising alternative for maintaining treatment adherence and reducing relapse risk in patients with schizophrenia. However, real-world data on its long-term effectiveness and safety remains limited.

Aims

To evaluate the effectiveness and safety of PP6M in a real-world setting over 12 months in patients with schizophrenia previously stabilized on monthly (PP1M) or 3-monthly (PP3M) formulations.

Methods

This was a multicenter, ambispective mirror-image study conducted across 10 Community Mental Health Units in Spain. A total of 158 patients with schizophrenia who switched from PP1M or PP3M to PP6M were followed at baseline, 6 months, and 12 months. Effectiveness was assessed through hospitalization rates, Clinical Global Impression (CGI), and Sheehan Disability Scale (SDS) scores. Safety, adverse effects, and substance use were also analyzed.

Results

A significant reduction in hospitalization was observed at 6 and 12 months compared to the prior year. CGI and SDS scores improved significantly over time. Patient retention at 12 months was 83%, resulting in a dropout rate of 17%. The primary reasons for dropout were clinical relapse (40.7%) and patient refusal (29.6%). Adverse events were reported in 38.2% of patients, mostly mild or moderate. A significant reduction in substance use, particularly cocaine, was also noted. Acceptance of PP6M was high, with nursing staff playing a key role in facilitating the transition.

Conclusions

PP6M is an effective and well-tolerated option for patients with schizophrenia in real-world clinical practice. It reduces hospitalizations, improves clinical outcomes, and may contribute to decreased substance use.

背景：棕榈酸帕利哌酮6个月制剂（PP6M）为维持精神分裂症患者的治疗依从性和降低复发风险提供了一种有希望的替代方案。然而，关于其长期有效性和安全性的实际数据仍然有限。目的：在现实环境中评估PP6M在先前每月（PP1M）或3个月（PP3M）制剂稳定的精神分裂症患者中超过12个月的有效性和安全性。方法这是一项在西班牙10个社区精神卫生单位进行的多中心、双视角镜像研究。共有158名精神分裂症患者从PP1M或PP3M切换到PP6M，分别在基线、6个月和12个月进行随访。通过住院率、临床总体印象（CGI）和Sheehan残疾量表（SDS）评分来评估疗效。安全性、不良反应和药物使用情况也进行了分析。结果6个月和12个月住院率较上年显著降低。随着时间的推移，CGI和SDS评分显著提高。12个月的患者保留率为83%，导致17%的辍学率。退出的主要原因是临床复发（40.7%）和患者拒绝（29.6%）。38.2%的患者报告了不良事件，大多为轻度或中度。还注意到药物使用，特别是可卡因的使用大大减少。PP6M的接受度较高，护理人员在促进过渡方面发挥了关键作用。结论spp6m治疗精神分裂症是一种有效且耐受性良好的治疗方案。它减少了住院治疗，改善了临床结果，并可能有助于减少药物使用。

{"title":"12-Month mirror study on the effectiveness and safety of six-month paliperidone palmitate in patients with schizophrenia: A Multicenter Andalusian Cohort (PAPSEM study)","authors":"Jesús García-Jiménez , Óscar Lafuente-Casanova , Rosario Salas , Carlota Rodríguez , Miguel Graciani-Pérez , Pablo Roque Leonardo-Caserta , Manuel López-Arroyo , Asunta Torres-Laborde , Luis Gutiérrez-Rojas","doi":"10.1016/j.psychres.2025.116903","DOIUrl":"10.1016/j.psychres.2025.116903","url":null,"abstract":"<div><h3>Background</h3><div>Paliperidone palmitate 6-month formulation (PP6M) offers a promising alternative for maintaining treatment adherence and reducing relapse risk in patients with schizophrenia. However, real-world data on its long-term effectiveness and safety remains limited.</div></div><div><h3>Aims</h3><div>To evaluate the effectiveness and safety of PP6M in a real-world setting over 12 months in patients with schizophrenia previously stabilized on monthly (PP1M) or 3-monthly (PP3M) formulations.</div></div><div><h3>Methods</h3><div>This was a multicenter, ambispective mirror-image study conducted across 10 Community Mental Health Units in Spain. A total of 158 patients with schizophrenia who switched from PP1M or PP3M to PP6M were followed at baseline, 6 months, and 12 months. Effectiveness was assessed through hospitalization rates, Clinical Global Impression (CGI), and Sheehan Disability Scale (SDS) scores. Safety, adverse effects, and substance use were also analyzed.</div></div><div><h3>Results</h3><div>A significant reduction in hospitalization was observed at 6 and 12 months compared to the prior year. CGI and SDS scores improved significantly over time. Patient retention at 12 months was 83%, resulting in a dropout rate of 17%. The primary reasons for dropout were clinical relapse (40.7%) and patient refusal (29.6%). Adverse events were reported in 38.2% of patients, mostly mild or moderate. A significant reduction in substance use, particularly cocaine, was also noted. Acceptance of PP6M was high, with nursing staff playing a key role in facilitating the transition.</div></div><div><h3>Conclusions</h3><div>PP6M is an effective and well-tolerated option for patients with schizophrenia in real-world clinical practice. It reduces hospitalizations, improves clinical outcomes, and may contribute to decreased substance use.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"356 ","pages":"Article 116903"},"PeriodicalIF":3.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal depression during armed conflict in Israel: Mental health risks and challenges, a cross-sectional study 以色列武装冲突期间的围产期抑郁症：心理健康风险和挑战，一项横断面研究。

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.psychres.2025.116910

Samira Alfayumi-Zeadna , Vered Bar , Galit Neufeld-kroszynski , Inbal Reuveni , Vered Maugami , Rena Bina

Background

The recent armed conflict between Israel and Hamas (October 7,2023) has impacted various populations, including perinatal women, whose mental health can be particularly vulnerable to deterioration during periods of conflict. This study aimed to assess the prevalence of perinatal depression symptoms (PNDs) during the war and identified related risk factors for PNDs.

Methods

This cross-sectional study included 862 women who were pregnant or up to 12 months postpartum. Participants filled out an online self-report questionnaire. PNDs were measured using the Edinburgh Postnatal Depression Scale (EPDS). Bivariate analyses (t-tests, χ² tests) were performed to examine associations between demographic, socioeconomic, and post-traumatic stress disorder (PTSD) symptoms and war-related variables, and PND. Multivariable logistic regression was used to identify independent risk factors for PND symptoms (EPDS ≥10).

Results

The prevalence of PNDs was 32.7 %, with an EPDS score of 10 or higher. Suicidal thoughts were reported by 8 % of participants and PTSD was reported by 30 %. Statistically significant associations were found between PNDs and posttraumatic stress disorder, with women who experienced PTSD being 2.5 times more likely to report PNDs. Other factors associated with increased risk of PNDs included loneliness, pregnancy status (pregnant women were 1.5 times more likely to report PNDs, reduction of family income due to the war, war-related property damage, and history of mental health diseases.

Conclusion

The findings demonstrate the severe impact of the war on the mental health of perinatal women, highlighting the need for provision of targeted mental health support during and after conflict situations to mitigate these adverse effects.

背景：最近以色列和哈马斯之间的武装冲突（2023年10月7日）影响了各种人群，包括围产期妇女，她们的心理健康在冲突期间特别容易恶化。本研究旨在评估战争期间围产期抑郁症状（PNDs）的患病率，并确定PNDs的相关危险因素。方法：这项横断面研究包括862名怀孕或产后12个月的妇女。参与者填写了一份在线自我报告问卷。pnd采用爱丁堡产后抑郁量表（EPDS）进行测量。采用双变量分析（t检验、χ 2检验）检验人口统计学、社会经济、创伤后应激障碍（PTSD）症状和战争相关变量与PND之间的关联。采用多变量logistic回归确定PND症状的独立危险因素（EPDS≥10）。结果：pnd患病率为32.7%，EPDS评分在10分及以上。8%的参与者报告有自杀念头，30%报告有创伤后应激障碍。统计上发现pnd与创伤后应激障碍之间存在显著的关联，经历过PTSD的女性报告pnd的可能性是创伤后应激障碍的2.5倍。与PNDs风险增加相关的其他因素包括孤独、怀孕状况（孕妇报告PNDs的可能性高出1.5倍）、战争导致的家庭收入减少、与战争有关的财产损失以及精神疾病史。结论：调查结果表明，战争对围产期妇女的心理健康造成严重影响，强调需要在冲突期间和冲突后提供有针对性的心理健康支持，以减轻这些不利影响。

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引用次数: 0

Genetic liability to mental disorders and being delivered via cesarean section 精神障碍的遗传易感性和通过剖宫产分娩。

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.psychres.2025.116871

Søren Dinesen Østergaard , Maria Speed , Alisha Silvia Mercedes Hall , Esben Agerbo , Katherine L. Musliner

Observational studies have reported that cesarean delivery is associated with increased risk of mental disorders in offspring. However, whether this represents causality is unclear. We aimed to investigate whether positive associations between cesarean section and mental disorder may be confounded by genetic liability to mental disorder.

We identified individuals born from 1996 to 2008 from the general population representative sub-cohort of the Lundbeck Foundation Initiative for Integrative Psychiatric Research who have been genotyped and calculated their polygenic risk scores for schizophrenia, bipolar disorder, depression, autism and ADHD. The association between these polygenic risk scores and being delivered via cesarean section (including planned and acute cesarean section analyzed separately) was examined using a generalized linear model with logit-link function and binomial distribution with adjustment for relevant covariates, yielding adjusted odds ratios (AOR).

The study population consisted of 17,050 individuals (8382 females and 8668 males) of which 2929 were delivered via cesarean section (1252 planned and 1739 acute). None of the five polygenic risk scores were associated with being delivered via cesarean section. However, in subgroup analyses, polygenic risk scores for schizophrenia (AOR=1.07 (95 %CI: 1.00;1.15), p = 0.047), bipolar disorder (AOR=1.07 (1.00;1.15), p = 0.048), and depression (AOR=1.06 (1.00;1.13), p = 0.048) were positively associated with delivery via planned cesarean section with 95 % confidence intervals not crossing 1. This was not the case for delivery via acute cesarean section.

In conclusion, associations between planned cesarean section and mental disorder may be confounded by genetic liability to severe mental disorder. This possibility should be considered in future studies to avoid overestimation of causality.

观察性研究报告称，剖宫产与后代患精神障碍的风险增加有关。然而，这是否代表因果关系尚不清楚。我们的目的是调查剖宫产与精神障碍之间的正相关是否可能被精神障碍的遗传易感性所混淆。我们从伦德贝克综合精神病学研究基金会倡议的一般人群代表性亚队列中选取了1996年至2008年出生的个体，对他们进行了基因分型，并计算了他们在精神分裂症、双相情感障碍、抑郁症、自闭症和多动症方面的多基因风险评分。这些多基因风险评分与剖宫产（包括分别分析的计划剖宫产和急性剖宫产）之间的关系，采用logt -link函数和二项分布的广义线性模型进行检验，并校正相关协变量，得出调整优势比（AOR）。研究人群包括17050名个体（8382名女性和8668名男性），其中2929名通过剖宫产分娩（1252名计划分娩，1739名急性分娩）。五项多基因风险评分均与剖宫产无关。然而，在亚组分析中，精神分裂症（AOR=1.07 (95% CI: 1.00;1.15), p = 0.047）、双相情感障碍（AOR=1.07 (1.00;1.15), p = 0.048）和抑郁症（AOR=1.06 (1.00;1.13), p = 0.048）的多基因风险评分与计划剖宫产呈正相关，95%可信区间不超过1。这不是通过急性剖宫产分娩的情况。总之，计划剖宫产和精神障碍之间的联系可能被严重精神障碍的遗传倾向所混淆。在未来的研究中应考虑这种可能性，以避免对因果关系的高估。

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引用次数: 0

Alice in wonderland syndrome: Down the rabbit hole of VigiBase® 爱丽丝梦游仙境综合症：掉进VigiBase®的兔子洞。

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-21 DOI: 10.1016/j.psychres.2025.116920

Diane A. Merino , Alexandre O. Gérard , Faredj Cherikh , Thibaud Lavrut , Susanne Thümmler , Florence Askenazy , Milou-Daniel Drici , François Montastruc

Alice in Wonderland Syndrome (AIWS) is a neurological disorder involving visual and perceptual distortions, such as altered size perception, sensations of levitation, and time distortion. Initially linked to migraines and epileptic seizures, AIWS has been associated later with tumors, infections, and both illicit and prescribed drugs. This study explores drug-related AIWS cases in the WHO global pharmacovigilance database, VigiBase®, with a focus on age-specific patterns. We queried VigiBase® for AIWS reports until December 15, 2024 and categorized them into pediatric and adult groups. Disproportionality analyses identified drug-AIWS associations using the lower bound of the confidence interval of the Information Component (IC₀₂₅). We conducted sensitivity analyses, with a focus on healthcare professionals reports and excluding COVID-19 cases. We identified 87 AIWS cases: 26 (29.9 %) pediatric and 45 (51.7 %) adult. Most (64.4 %) were serious, with recovery documented in 79.6 %. COVID-19 vaccines, montelukast, and aripiprazole were most frequently reported. Montelukast showed the strongest signal in both adults (IC 4.2[3.2–5.0]) and children (IC 3.2[1.7–4.2]), followed by methylphenidate in pediatric cases (IC 2.3[0.3–3.5]). Adults showed signals for sertraline (IC 3.4[2.1–4.4]), topiramate (IC 3.1[1.3–4.2]), and aripiprazole (IC 2.1[3.5–4.4]). Signal consistency was confirmed by both sensitivity analyses. This study sheds light on age-dependent profiles of drug-associated AIWS. Montelukast, aripiprazole, sertraline, and topiramate were disproportionately associated, consistent with prior case reports. Clinicians should consider AIWS when visual distortions arise during such treatment, particularly in youths treated with methylphenidate or montelukast. While typically reversible, AIWS warrants clinical awareness and careful risk-benefit assessment. As causality cannot be established, further population-based studies are needed to confirm these findings.

爱丽丝梦游仙境综合症（AIWS）是一种神经系统疾病，涉及视觉和知觉扭曲，如大小感知改变、悬浮感和时间扭曲。最初与偏头痛和癫痫发作有关，后来与肿瘤、感染以及非法药物和处方药有关。本研究探讨了世卫组织全球药物警戒数据库VigiBase®中与药物相关的AIWS病例，重点关注年龄特异性模式。我们查询了VigiBase®的AIWS报告，直到2024年12月15日，并将其分为儿科和成人组。歧化分析使用信息分量置信区间（IC025）的下界确定了药物与aiws的关联。我们进行了敏感性分析，重点关注医疗保健专业人员的报告，并排除了COVID-19病例。我们确定了87例AIWS病例：26例（29.9%）儿童和45例（51.7%）成人。大多数（64.4%）是严重的，79.6%有恢复记录。最常报道的是COVID-19疫苗、孟鲁司特和阿立哌唑。孟鲁司特在成人（IC 4.2[3.2-5.0]）和儿童（IC 3.2[1.7-4.2]）中均表现出最强的信号，其次是哌醋甲酯在儿科（IC 2.3[0.3-3.5]）。成人表现出舍曲林（IC 3.4[2.1-4.4]）、托吡酯（IC 3.1[1.3-4.2]）和阿立哌唑（IC 2.1[3.5-4.4]）的信号。两种敏感性分析均证实了信号的一致性。这项研究揭示了药物相关性AIWS的年龄依赖性。孟鲁司特、阿立哌唑、舍曲林和托吡酯不成比例地相关，与先前的病例报告一致。当这种治疗过程中出现视觉扭曲时，临床医生应该考虑AIWS，特别是在使用哌甲酯或孟鲁司特治疗的青少年中。虽然AIWS通常是可逆的，但需要临床意识和仔细的风险-收益评估。由于无法确定因果关系，需要进一步的基于人群的研究来证实这些发现。

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引用次数: 0

Real-time emotional distress during a national trauma: Changes in suicidality, depression, and loneliness among helpline users in the aftermath of October 7, 2023 terror attack in Israel 国家创伤期间的实时情绪困扰：2023年10月7日以色列恐怖袭击后求助热线用户自杀、抑郁和孤独的变化

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-15 DOI: 10.1016/j.psychres.2025.116911

Meytal Grimland , Joy Benatov , Yael Segal-Elbak , Noam Munz , Yarden Itzhaky , Avi Segal , Loona Ben Dayan , Inbar Shenfeld , Kobi Gal , Yossi Levi-Belz

Importance

Digital chat-based helplines provide a real-time view of population distress during mass trauma. Few studies have tracked how suicidality, depression, and loneliness evolve when crisis strikes.

Objective

To quantify help-seeking for suicidality, depression, and loneliness among Israeli helpline users before and after the October 7, 2023, terrorist attack and the subsequent war, using time-series text data from a national digital mental-health platform.

Design, Setting, and Participants

We conducted an observational cohort analysis of 17,523 anonymized text chats at the Sahar helpline across two 8-month periods: pre-crisis (Oct 7, 2022–May 31, 2023; n = 6,020) and crisis (Oct 7, 2023–May 31, 2024; n = 11,503). All chats occurred during identical service hours. We used Facebook’s Prophet model, chi-square and z-tests, and segmented linear regression.

Main Outcomes

Proportions of chats classified as suicidality, depression, or loneliness; deviations from expected pre-crisis forecasts; and demographic shifts by age and gender.

Results

The crisis period saw a decrease in the share of suicidality-related chats (17.8 % → 12.9 %; Δ = –4.9 pp) and depression-related chats (17.8 % → 8.2 %; Δ = –9.6 pp; both p < 0.001). Loneliness-related chats, however, rose (14.7 % → 19.0 %; Δ = +4.3 pp; p < 0.001). Prophet forecasts trained on pre-crisis data under-predicted crisis loneliness peaks and depression troughs, indicating major departures from baseline. Regression confirmed an initial spike followed by gradual adaptation in help-seeking.

Conclusions and Relevance

National trauma reshapes not only overall help-seeking volume but also the content of distress: acute loneliness surges even as suicidality and depression expressions recede. These findings argue for real-time digital surveillance to guide targeted loneliness-reduction and social-connection interventions during crises.

重要性基于数字聊天的帮助热线提供了大规模创伤期间人们痛苦的实时视图。很少有研究追踪危机来袭时自杀、抑郁和孤独是如何演变的。目的利用国家数字心理健康平台的时间序列文本数据，量化2023年10月7日恐怖袭击及随后的战争前后以色列求助热线用户的自杀、抑郁和孤独求助情况。设计、环境和参与者我们对萨哈尔热线的17523个匿名文本聊天进行了观察性队列分析，时间跨度为8个月：危机前（2022年10月7日- 2023年5月31日，n = 6020）和危机期（2010月7日- 2024年5月31日，n = 11,503）。所有聊天都发生在相同的服务时间内。我们使用了Facebook的Prophet模型、卡方检验和z检验以及分段线性回归。主要结果被归类为自杀、抑郁或孤独的聊天比例；偏离危机前预期；人口结构也随着年龄和性别的变化而变化。结果危机期自杀相关聊天比例（17.8%→12.9%；Δ = -4.9 pp）和抑郁相关聊天比例（17.8%→8.2%；Δ = -9.6 pp; p < 0.001）下降。然而，与孤独相关的聊天增加了（14.7%→19.0%；Δ = +4.3 pp; p < 0.001）。基于危机前数据训练的先知预测低估了危机中孤独的高峰和抑郁的低谷，这表明了与基线的重大偏离。回归证实了最初的高峰之后是寻求帮助的逐渐适应。国家创伤不仅重塑了总体求助量，也重塑了痛苦的内容：即使自杀倾向和抑郁表达减少，急性孤独感也会激增。这些发现表明，在危机期间，实时数字监控可以指导有针对性的减少孤独感和社会联系干预。

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引用次数: 0

Association between childbearing history and depressive symptoms in postmenopausal women: analysis of data from NHANES 2005-2018 绝经后妇女生育史与抑郁症状之间的关系：NHANES 2005-2018数据分析

IF 3.9 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.psychres.2025.116882

Linling Zhu , Xinyun Yang , Dan Zhang

Background

Depression is common in postmenopausal women, yet the link with childbearing history remains poorly understood.

Methods

A total of 7387 postmenopausal women were enrolled, gathered from NHANES spanning 2005 to 2018. Multivariable logistic regression models were applied to evaluate the associations between depressive symptoms and both the timing and number of live births.

Results

After adjusting for potential confounding variables, women with first live birth at the age of ≥30 years had 44 % (OR: 0.56, 95 %CI: 0.31-1.00) decreased risk of depressive symptoms, compared to those with first live birth at the age of <20 years. Similarly, compared to women with last live birth at the age of <30 years, those with last live birth at 30≤ <35 years showed a decreased risk of depressive symptoms (OR: 0.75, 95 %CI: 0.56-0.99, p=0.046). On the other hand, after correction for a variety of potential confounding variables, the number of pregnancies and the number of live births showed no significant association with depressive symptoms in postmenopausal women.

Conclusions

The ages at first and last live birth, rather than the number of pregnancies and the number of live births, are associated with depressive symptoms during the postmenopausal period. This distinction is crucial for developing targeted interventions and support systems to enhance mental health in postmenopausal women.

背景：抑郁症在绝经后妇女中很常见，但其与生育史的关系仍然知之甚少。方法从2005年至2018年的NHANES中收集了7387名绝经后妇女。应用多变量logistic回归模型来评估抑郁症状与活产时间和数量之间的关系。结果：在调整了潜在的混杂变量后，年龄≥30岁首次活产的妇女与年龄≥20岁首次活产的妇女相比，抑郁症状的风险降低44% （OR: 0.56, 95% CI: 0.31-1.00）。同样，与最后一次活产为30岁的妇女相比，最后一次活产为30岁≤35岁的妇女出现抑郁症状的风险降低（OR: 0.75, 95% CI: 0.56-0.99, p=0.046）。另一方面，在对各种潜在的混杂变量进行校正后，怀孕次数和活产次数与绝经后妇女的抑郁症状没有显着关联。结论与绝经后抑郁症状相关的不是怀孕次数和活产次数，而是首次和最后一次活产年龄。这种区别对于制定有针对性的干预措施和支持系统以增强绝经后妇女的心理健康至关重要。

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引用次数: 0