Psychiatry Research最新文献

{"title":"Understanding the roots of suicide in veterinarians to inform prevention: A scoping review","authors":"Mateus Eduardo Romão ,&nbsp;Giacomo Belli ,&nbsp;Rebeca Gomes de Oliveira ,&nbsp;Valentina Sommovigo ,&nbsp;Silvia Damiana Visonà ,&nbsp;Simone Scoccianti ,&nbsp;Ilaria Setti ,&nbsp;Makilim Nunes Baptista ,&nbsp;Serena Barello","doi":"10.1016/j.psychres.2026.116946","DOIUrl":"10.1016/j.psychres.2026.116946","url":null,"abstract":"<div><h3>Background</h3><div>Veterinarians experience one of the highest suicide rates of any profession. Beyond fatalities, growing evidence documents suicidal ideation and non-fatal attempts, but findings are fragmented.</div></div><div><h3>Objective</h3><div>To map risk and protective factors for suicidal behavior—including ideation, attempts, and death among licensed veterinarians.</div></div><div><h3>Methods</h3><div>Following Joanna Briggs Institute guidance and PRISMA-ScR reporting standards, we searched PubMed, Scopus, Web of Science, PsycINFO, and CINAHL (2009–2024). Eligible studies examined empirical associations between any risk or protective factor and suicidal outcomes in veterinarians. Data were extracted on study design, sample, country, outcome, and key findings.</div></div><div><h3>Results</h3><div>Twelve studies from six countries met inclusion criteria (nine cross-sectional surveys, one qualitative interview study, one focus-group study, one retrospective mortality analysis). Suicide risk reflected the convergence of occupational stressors (workload, client conflict, euthanasia), psychological vulnerabilities (depression, perfectionism, burnout), demographic variables (gender, early-career status), and access to lethal means (particularly pentobarbital). Protective elements included peer and social support, job satisfaction, adaptive coping, and indirect secure storage of euthanasia agents. Evidence was limited by the predominance of cross-sectional self-report designs and by restricted geographic coverage.</div></div><div><h3>Conclusions</h3><div>Veterinarians face distinctive pressures that heighten the risk of suicidal ideation, attempts, and death. Multi-level strategies, such as supportive work environments, coping-skills training, peer-support programs, and evaluation of means-restriction policies, should be prioritized. Further longitudinal and cross-national studies are needed to clarify risk trajectories and strengthen preventive action.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116946"},"PeriodicalIF":3.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of war on teachers’ burnout: The moderating role of emotion regulation","authors":"Demetria Hila Neustadter ,&nbsp;Dana Rose Cohen ,&nbsp;Dana Lassri ,&nbsp;Joy Benatov ,&nbsp;Noga Cohen","doi":"10.1016/j.psychres.2026.116942","DOIUrl":"10.1016/j.psychres.2026.116942","url":null,"abstract":"<div><div>Teachers are at high risk of experiencing job-related burnout, especially during times of enduring stress, such as wartime. Therefore, it is essential to understand risk and protective factors among teachers exposed to these stressful situations.</div><div>The current study examined whether cognitive reappraisal, a well-established adaptive emotion regulation strategy, moderates the link between war exposure, war-related stress, and burnout among Israeli Jewish and Arab high school teachers during the Israel-Hamas war that began in October 2023. We hypothesized that teachers who use cognitive reappraisal more frequently would exhibit weaker associations between war exposure, war-related stress, and burnout. A total of 329 high school teachers (73.6 % women, 26.4 % men) participated in an online survey conducted eight months after the war began. Participants completed measures assessing war exposure, war-related stress, habitual use of cognitive reappraisal, and burnout. Correlational analyses revealed that while war-related stress was associated with burnout, war exposure showed no direct correlation with burnout. Supporting our hypothesis, cognitive reappraisal was negatively associated with burnout. Moderation analyses revealed that cognitive reappraisal significantly moderated the link between war exposure and burnout, with simple slopes analyses indicating that the link between war exposure and burnout was weaker among teachers who reported a higher tendency to use cognitive reappraisal. A similar but not significant trend was observed for war-related stress. Findings suggest that cognitive reappraisal serves as a protective factor against teacher burnout during wartime and highlights the importance of promoting emotion regulation strategies to support teachers’ mental health and enhance resilience during major crises.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116942"},"PeriodicalIF":3.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide ideation, suicide risk, and firearm storage practices and attitudes among U.S. uniformed law enforcement officers’","authors":"Michael LeDuc,&nbsp;Julianne Cary,&nbsp;Cole Marvin,&nbsp;Sean M. Mitchell","doi":"10.1016/j.psychres.2026.116940","DOIUrl":"10.1016/j.psychres.2026.116940","url":null,"abstract":"<div><h3>Background</h3><div>U.S. uniformed law enforcement officers’ (ULEOs’) intention to purchase firearms increased recently, coinciding with increasing suicide risk, but research in this area remains sparse. We examined firearm storage practices and attitudes among U.S. ULEOs and their relation to suicide ideation (SI) and suicide risk.</div></div><div><h3>Method</h3><div>Currently employed U.S. ULEOs (<em>N</em> = 271) completed a cross-sectional online-based survey in June and July 2023.</div></div><div><h3>Results</h3><div>On average, ULEOs “agree” with positive firearm statements. Regarding firearm storage practices, 54.6% always store a firearm at home, 35.2% always keep a firearm loaded, 35.2% always store their firearm with a locking device, and 50.2% always safely store firearms in a locked location. Higher SI was associated with lower odds of always storing a firearm at home, loaded, and in a secure location, whereas higher suicide risk was associated with lower odds of always storing a firearm at home and in a secure location.</div></div><div><h3>Conclusion</h3><div>ULEOs reported higher positive firearm attitudes and rates of always storing a firearm loaded and never using a locking device than other samples in the literature. Our findings highlight the importance of SI and suicide risk in safe firearm storage practices, which could aid in firearm death and suicide prevention efforts.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116940"},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlates of individuals with and without misophonia in the U.S.: Results from a population-based study","authors":"Alexandra Freshley ,&nbsp;Heather L. Clark ,&nbsp;Mary J. Schadegg ,&nbsp;Laura J. Dixon","doi":"10.1016/j.psychres.2026.116941","DOIUrl":"10.1016/j.psychres.2026.116941","url":null,"abstract":"<div><div>Misophonia is a disorder characterized by strong negative affective, physiological, cognitive, and behavioral reactions to specific sounds (e.g., chewing, swallowing). Studies have begun to investigate co-occurring psychological and audiological disorders with misophonia, but are limited by methodology and generalizability. This study investigated the rate of comorbid disorders in a sample of individuals with and without misophonia using a nationally representative sample in the United States. Data were collected through Ipsos KnowledgePanel—a large, probability-based web panel that is representative of the United States. Participants were invited to complete a brief self-report survey of previous and current psychological and auditory-sensory symptoms and diagnoses. Over half (62.5%) of the misophonia sample reported they had received at least one psychological disorder diagnosis, wherein depression (48.9%) and anxiety disorders (46.7%) were the most commonly reported. Separate hierarchical multivariate binary logistic regression results demonstrate individuals with misophonia (<em>n</em> = 185) are more likely to report current mental health and auditory-sensory symptoms compared to individuals without misophonia (<em>n</em> = 1644) regardless of demographic factors. Further, hierarchical multivariate binary logistic results show individuals with misophonia are more likely to report lifetime diagnoses of all psychological, auditory-sensory, and communication disorders except hyperacusis, autism spectrum disorders, and certain behavior disorders compared to individuals without misophonia. Comorbidity rates were higher in the misophonia sample, and misophonia status was significantly associated with the presence of other clinical syndromes. Findings advance characterization of misophonia by highlighting the elevated co-occurrence rates of psychological and auditory-sensory disorders compared to individuals without misophonia.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116941"},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agitation and anxiety features define a more severe phenotype in unipolar depression","authors":"Maria Luca ,&nbsp;Antonina Luca ,&nbsp;Stefano Barlati ,&nbsp;Lisa Buson ,&nbsp;Valentina Menesello ,&nbsp;Anna Magistrali ,&nbsp;Rosana Carvalho Silva ,&nbsp;Giulia Perusi ,&nbsp;Gabriele Nibbio ,&nbsp;Stefano Bignotti ,&nbsp;Giovanni Battista Tura ,&nbsp;Raffaele Ferri ,&nbsp;Massimo Gennarelli ,&nbsp;Antonio Vita ,&nbsp;Daniel Souery ,&nbsp;Siegfried Kasper ,&nbsp;Joseph Zohar ,&nbsp;Stuart Montgomery ,&nbsp;Panagiotis Ferentinos ,&nbsp;Dan Rujescu ,&nbsp;Edoardo Spina","doi":"10.1016/j.psychres.2025.116928","DOIUrl":"10.1016/j.psychres.2025.116928","url":null,"abstract":"<div><h3>Background</h3><div>Agitated depression, conventionally associated with bipolar disorder, may also constitute a clinically significant subtype within unipolar major depressive disorder (MDD). Nevertheless, the interrelationship between agitation and anxiety symptoms and their clinical implications in unipolar depression remain largely unexamined.</div></div><div><h3>Methods</h3><div>We examined three large, independent cohorts of patients with MDD from the GSRD (<em>n</em> = 1588), STAR*D (<em>n</em> = 1532), and PANDORA (<em>n</em> = 244) studies. A composite agitation–anxiety score was computed by summing relevant items of the retrospective Montgomery-Äsberg depression rating scale (rMADRS) in GSRD, the Hamilton Depression Rating Scale 17-items (HAM-D) in PANDORA and the 30-item Inventory for Depressive Symptomatology, Clinician-rated (IDS-C₃₀) in STAR*D. Patients were then stratified into patients with agitation-anxiety (AA+) and without agitation-anxiety (AA-) based on the median scores of each cluster. Associations between agitation–anxiety features and depression severity, suicidal ideation, disease duration, treatment response, and family history of bipolar disorder were evaluated using univariate and multivariate analyses.</div></div><div><h3>Results</h3><div>A total of 3364 participants were analyzed. AA+ patients showed significantly greater baseline depression severity (independent from agitation–anxiety items) across all datasets. Moreover, agitation–anxiety features correlated with higher rates of suicidal ideation (STAR*D, GSRD), longer disease duration (GSRD), and lower treatment response (STAR*D), independent of age and sex. No significant associations with family history of bipolar disorder were found.</div></div><div><h3>Conclusions</h3><div>Features of agitated depression define a more severe depressive phenotype within depressive episodes and may represent a clinically relevant dimension in unipolar MDD. A transdiagnostic approach may enhance future research and treatment strategies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116928"},"PeriodicalIF":3.9,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events associated with classic psychedelics and MDMA: a real-world population-based study using the WHO pharmacovigilance database (VigiBase)","authors":"Omer A. Syed ,&nbsp;Sean M. Nestor ,&nbsp;Muhammad Ishrat Husain ,&nbsp;Mark Sinyor ,&nbsp;Fahad Alam ,&nbsp;Peter Giacobbe","doi":"10.1016/j.psychres.2025.116929","DOIUrl":"10.1016/j.psychres.2025.116929","url":null,"abstract":"<div><div>Psychedelic use has greatly increased within clinical and recreational settings over recent years. While demonstrating a favorable safety profile within certain clinical populations, little empirical research has explored safety of psychedelic use within real-world samples. Using the World Health Organization (WHO) VigiBase, a comprehensive global pharmacovigilance database with voluntary spontaneous reporting of adverse events (AEs) from real-world clinical and recreational populations, we examined reports for classic psychedelics and MDMA. Most reports were made for MDMA (<em>n</em> = 1573) and LSD (<em>n</em> = 394), while psilocybin (<em>n</em> = 56), DMT (<em>n</em> = 18), and mescaline (<em>n</em> = 15) had fewer reports. The most common AEs for all substances were psychiatric in nature, specifically surrounding substance or drug abuse and dependence. Reports of overdose constituted 1.1 to 1.7 % of total AEs. Pregnancy-related and congenital disorders were rare. Compared to the acetaminophen control, LSD and MDMA were associated with significantly greater odds for the reported AEs of alcohol abuse (LSD: ROR=45.7, 95 % CI: 27.2 – 76.9; MDMA: ROR=19.2, 95 % CI: 12.2 – 30.4), substance use disorder (LSD: ROR=71.1, 95 % CI: 36.3 – 139.2; MDMA: ROR=129.9, 95 % CI: 78.4 – 215.5) and substance dependence (LSD: ROR=215.1, 95 % CI: 69.0 – 670.3; MDMA: ROR=76.8, 95 % CI: 25.5 – 231.8). These reports were also greater than those associated with the external positive control, oxycodone. Taken together, this exploratory study provides the first analysis of AEs associated with psychedelics reported to a global pharmacovigilance database and can inform their real-world safety. Findings should be considered in light of limitations surrounding co-use of other substances and potential deterrence towards reporting use of illicit substances.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116929"},"PeriodicalIF":3.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the label: identifying modifiable predictors of ADHD-like adaptation in young adults","authors":"Anıl Alp ,&nbsp;Ali Kandeğer ,&nbsp;Zeynep Nazlı Benekli ,&nbsp;İlayda Ertekin ,&nbsp;Duygu Akbulut ,&nbsp;Başak Dinçer ,&nbsp;Doğa Uçar ,&nbsp;Başaran Demir","doi":"10.1016/j.psychres.2025.116927","DOIUrl":"10.1016/j.psychres.2025.116927","url":null,"abstract":"<div><h3>Background</h3><div>Attention Deficit Hiperactivity Disorder (ADHD) diagnoses have risen sharply, but this surge may partly stem from diagnostic oversimplification rather than genuine neurodevelopmental pathology. University students, a population particularly prone to self-attributed cognitive difficulties, often report inattention that prompts hasty clinical conclusions and stimulant-seeking behaviour, despite lacking early developmental indicators. This study aimed to disentangle neurodevelopmental ADHD traits from ADHD-like Adaptation in university students by integrating subjective attention complaints, clinical ADHD symptom profiles, and objective cognitive measures.</div></div><div><h3>Methods</h3><div>A total of 223 university students without formal psychiatric diagnoses were categorized into Possible ADHD (<em>n</em> = 50), ADHD-like Adaptation (<em>n</em> = 36), and No ADHD (<em>n</em> = 137) groups based on current symptoms (according to DSM-5 criteria) and retrospective childhood ADHD traits (assessed using the Wender–Utah Rating Scale). Self-perceived attention deficit (SPAD) was also assessed to capture participants’ subjective experiences of attentional difficulties independent of formal diagnosis. Groups were compared in terms of cognitive performance <em>(Stroop Test, Trail Making Test, MOXO-<span>d</span>-CPT)</em>, lifestyle factors <em>(digital screen time, sleep quality assessed by the Pittsburgh Sleep Quality Index, and chronotype)</em>, and internalizing symptoms <em>(assessed using the Beck Anxiety and Depression Inventories)</em>. Single-step and chained mediation analyses explored the relative contributions of neurodevelopmental vulnerability and contextual variables to ADHD symptomatology.</div></div><div><h3>Results</h3><div>No significant differences were observed in objective measures of attentional accuracy or timing, either across SPAD groups or across clinical ADHD groups. However, individuals with SPAD(+), Possible ADHD, and ADHD-like Adaptation exhibited higher levels of impulsivity and hyperactivity compared with their respective control groups. ADHD symptoms were associated with poor sleep quality, problematic technology use, risky alcohol consumption, elevated stress, anxiety and depression. Importantly, mediation analyses revealed that these lifestyle and psychosocial risk factors accounted for only a modest portion of adult ADHD-like Adaptation (indirect β ranging from 0.140 to 0.241, all <em>p</em>&lt; .001; mediation percentages between 20.41% and 29.93%). The primary determinant remained neurodevelopmental ADHD vulnerability (direct β range: 0.497 – 0.546, all <em>p</em>&lt; .001).</div></div><div><h3>Conclusions</h3><div>These findings suggest that subjective attention difficulties without clear neurodevelopmental markers may constitute a pathway through which processes of self-labeling and clinical misattribution increase vulnerability to ADHD overdiagnosis.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116927"},"PeriodicalIF":3.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic monitoring and control among patients with type 2 diabetes prescribed second generation antipsychotics","authors":"Jiali Guo ,&nbsp;David R. Goldsmith ,&nbsp;Robert O. Cotes ,&nbsp;Jithin Sam Varghese","doi":"10.1016/j.psychres.2025.116925","DOIUrl":"10.1016/j.psychres.2025.116925","url":null,"abstract":"<div><h3>Objective</h3><div>Annual monitoring of metabolic control is recommended for patients with type 2 diabetes (T2D) prescribed second-generation antipsychotics (SGA), with uncertain validity as a performance measure for health plans. To study the rates of metabolic monitoring and control in the three years after antipsychotic prescription following T2D diagnosis.</div></div><div><h3>Methods</h3><div>We used the electronic health record data from Epic Cosmos. We identified adult patients (<em>n</em> = 469,503) with newly diagnosed T2D between 2012 and 2021 as those who were prescribed SGA (6.9%), first-generation antipsychotics (FGA) (4.4%), or neither (88.7%). Rates of metabolic monitoring (weight, HbA1c, LDL, and estimated glomerular filtration rate using CKD-EPI 2021 [eGFR]) and control (HbA1c ≤8%, blood pressure ≤140/90 mmHg, and LDL ≤100 mg/dL) in the three years after first prescription of SGA, FGA or neither were modeled used logistic generalized estimating equations.</div></div><div><h3>Results</h3><div>The sample was 52% female, 17% non-Hispanic Black, and 6.7% Hispanic; mean age was 63.8 years (SD: 13.1). In Year 1, relative to those prescribed neither, the adjusted rates of monitoring of weight were similar but HbA1c (Neither: 92.3%[95%CI: 88.4–95.0], SGA: 81.9%[95%CI: 73.4–88.1], FGA: 73.6%[95%CI: 62.6–82.3]) and LDL (Neither: 71.5%[95%CI: 62.5–79.0], SGA: 57.8%[95%CI: 47.0–68.0], FGA: 49.9%[95%CI: 38.7–61.1]) were lower, among those prescribed antipsychotics, with overlapping confidence intervals. eGFR was monitored more frequently among patients prescribed SGA and FGA only in Year 1 (Neither: 66.4%[95%CI: 57.1–74.7], SGA: 76.3%[95%CI: 67.4–83.4], FGA: 82.0%[95%CI: 73.5–88.2]). Rates decreased over time for all groups across all outcomes. Rates of metabolic control were higher than national averages, but similar over time and did not differ between groups.</div></div><div><h3>Conclusion</h3><div>Declining rates of metabolic monitoring, independent of antipsychotic prescription, present opportunities for quality improvement initiatives among patients with T2D.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116925"},"PeriodicalIF":3.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated intermittent theta burst stimulation effectively and rapidly reduces suicidal ideation in depression patients: A randomized, sham-controlled study","authors":"Li-Fen Chen ,&nbsp;Wei-Chou Chang ,&nbsp;Chi-Hsiang Chung ,&nbsp;Alexander T. Sack ,&nbsp;Ching-En Lin ,&nbsp;Hsin-An Chang","doi":"10.1016/j.psychres.2025.116926","DOIUrl":"10.1016/j.psychres.2025.116926","url":null,"abstract":"<div><h3>Background</h3><div>Suicidal ideation is common among patients with treatment-resistant depression (TRD), underscoring the need for rapid and safe therapeutic options.</div></div><div><h3>Objective</h3><div>This study examined whether accelerated intermittent theta burst stimulation (iTBS) can rapidly reduce suicidal ideation in TRD inpatients while maintaining pharmacological stability and cognitive safety.</div></div><div><h3>Methods</h3><div>In a randomized, double-blind, placebo-controlled trial, 100 TRD inpatients with suicidal ideation received either active or sham accelerated iTBS over two weeks. The primary outcome was change in Beck Scale for Suicide Ideation (BSS) scores; secondary outcomes included depressive symptoms and cognitive performance.</div></div><div><h3>Results</h3><div>Active accelerated iTBS produced significantly greater reductions in suicidal ideation than sham beginning at week 2 (mean ± SD: 10.0 ± 7.4 vs. 13.2 ± 8.8, <em>p</em> = 0.036), with effects sustained through week 6. Response rates on the BSS were also higher in the active group at week 2 (50% vs. 18%, <em>p</em> &lt; 0.001). Antidepressant effects emerged as early as week 1. Importantly, these clinical improvements occurred without changes in concomitant medications and without any adverse effects on cognitive function, supporting the specificity and safety of the intervention.</div></div><div><h3>Conclusions</h3><div>Accelerated iTBS is a rapid-acting, safe, and cognitively neutral treatment for reducing suicidal ideation and depressive symptoms in TRD inpatients, highlighting its potential utility in acute psychiatric care.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116926"},"PeriodicalIF":3.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor structure of the Internet Gaming Disorder Scale: an Exploratory Graph Analysis approach in Spanish university gamers","authors":"Júlia Gisbert-Pérez,&nbsp;Adrián García-Mollá,&nbsp;José M. Tomás,&nbsp;Manuel Martí-Vilar,&nbsp;Laura Badenes-Ribera","doi":"10.1016/j.psychres.2025.116924","DOIUrl":"10.1016/j.psychres.2025.116924","url":null,"abstract":"<div><h3>Importance</h3><div>Internet gaming disorder (IGD) has emerged as a growing concern, particularly among adolescents and young adults. This concern has prompted the development of standardized tools for IGD assessment, such as the Internet Gaming Disorder Scale (IGDS). IGDS is based on the DSM-V diagnostic criteria, and has been mainly used as a unidimensional measure of IGD.</div></div><div><h3>Objective</h3><div>This study aimed to translate and validate the Spanish version of the IGDS in a sample of university students (<em>N</em> = 274, <em>M_age</em>= 21.64 years, <em>SD_age</em> = 2.93, % male = 59.7%).</div></div><div><h3>Methods</h3><div>Exploratory Graph Analysis (EGA) followed by Confirmatory Factor Analysis (CFA) were conducted, and internal consistency and convergent validity were assessed.</div></div><div><h3>Results</h3><div>EGA identified a bidimensional structure comprising (1) cognitive–emotional symptoms and (2) relational-problem outcomes, which was confirmed through CFA. Both dimensions demonstrated excellent reliability and adequate convergent validity.</div></div><div><h3>Conclusion</h3><div>The Spanish IGDS is a psychometrically valid instrument for assessing IGD, allowing for an accurate distinction between gaming intensity and functional impairment. These findings challenge the traditional unidimensional perspective and support a biaxial conceptualization of IGD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116924"},"PeriodicalIF":3.9,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}