Pub Date : 2026-03-10DOI: 10.1016/j.psychres.2026.117086
Joscelyn E Fisher, Christopher C Andersen, Jing Zhou, Alexander J Rice, Christin M Ogle, Luke L Sumberg, Stephen J Cozza
Background: Belief in a just world is the conviction that the world is fundamentally fair and that people deserve to be rewarded for admirable actions and punished for unjust actions. However, these beliefs can be challenged by a traumatic event, especially bereavement by a sudden and violent death, increasing the risk for Prolonged Grief Disorder (PGD). This study examined the association between belief in a just world and PGD among family members bereaved by the September 11, 2001 terrorist attacks.
Methods: 380 bereaved family members provided responses on a cross-sectional survey that included the Inventory of Complicated Grief (ICG) and the Global Belief in a Just World (BJW). Multivariable logistic regressions were used to examine associations between endorsed BJW items and meeting threshold for PGD. An interaction between BJW and relationship type to the deceased was also evaluated.
Results: A weaker belief in a just world (as indicated by higher scores) was associated with an increased risk of meeting the threshold for PGD among bereaved parents, but not among other relationships to the deceased.
Conclusions: The death of a family member due to sudden and violent causes, especially when the decedent is a child, increases the risk for PGD. However, a stronger belief in a just world can potentially buffer against PGD. These findings highlight the need to incorporate perceptions of justice within the world as a potential therapeutic target for grief support.
{"title":"Belief in a just world and prolonged grief disorder among individuals bereaved by 9/11.","authors":"Joscelyn E Fisher, Christopher C Andersen, Jing Zhou, Alexander J Rice, Christin M Ogle, Luke L Sumberg, Stephen J Cozza","doi":"10.1016/j.psychres.2026.117086","DOIUrl":"https://doi.org/10.1016/j.psychres.2026.117086","url":null,"abstract":"<p><strong>Background: </strong>Belief in a just world is the conviction that the world is fundamentally fair and that people deserve to be rewarded for admirable actions and punished for unjust actions. However, these beliefs can be challenged by a traumatic event, especially bereavement by a sudden and violent death, increasing the risk for Prolonged Grief Disorder (PGD). This study examined the association between belief in a just world and PGD among family members bereaved by the September 11, 2001 terrorist attacks.</p><p><strong>Methods: </strong>380 bereaved family members provided responses on a cross-sectional survey that included the Inventory of Complicated Grief (ICG) and the Global Belief in a Just World (BJW). Multivariable logistic regressions were used to examine associations between endorsed BJW items and meeting threshold for PGD. An interaction between BJW and relationship type to the deceased was also evaluated.</p><p><strong>Results: </strong>A weaker belief in a just world (as indicated by higher scores) was associated with an increased risk of meeting the threshold for PGD among bereaved parents, but not among other relationships to the deceased.</p><p><strong>Conclusions: </strong>The death of a family member due to sudden and violent causes, especially when the decedent is a child, increases the risk for PGD. However, a stronger belief in a just world can potentially buffer against PGD. These findings highlight the need to incorporate perceptions of justice within the world as a potential therapeutic target for grief support.</p>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"360 ","pages":"117086"},"PeriodicalIF":3.9,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1016/j.psychres.2026.117083
Qiming Li, Xinyu Lu
We comment on the recent meta-analysis examining facial expression recognition (FER) in older adults with major depressive disorder (MDD). While the study provides an important quantitative synthesis at the intersection of socioemotional aging and depression, several interpretative and methodological issues merit clarification. First, negative standardized mean differences were interpreted in parts of the discussion as reflecting heightened sensitivity to negative emotions, although reduced accuracy in forced-choice paradigms more directly indicates impaired decoding rather than hypersensitivity. Second, substantial heterogeneity was markedly reduced only after exclusion of influential studies, raising concerns that pooled effects may be contingent on study selection and potentially reflect methodological compression. Third, meta-regression findings suggest that sample size and stimulus modality meaningfully influence effect estimates, underscoring design-related variability. Finally, cognitive status was not formally modeled as a moderator, despite its potential relevance to emotion recognition performance in late-life depression. We suggest that clearer differentiation between perceptual deficit and interpretative bias, alongside greater attention to methodological and cognitive moderators, would strengthen theoretical inference and future meta-analytic work in this domain.
{"title":"Comment on \"Facial expression recognition in older adults with depression: A meta-analytic review\".","authors":"Qiming Li, Xinyu Lu","doi":"10.1016/j.psychres.2026.117083","DOIUrl":"https://doi.org/10.1016/j.psychres.2026.117083","url":null,"abstract":"<p><p>We comment on the recent meta-analysis examining facial expression recognition (FER) in older adults with major depressive disorder (MDD). While the study provides an important quantitative synthesis at the intersection of socioemotional aging and depression, several interpretative and methodological issues merit clarification. First, negative standardized mean differences were interpreted in parts of the discussion as reflecting heightened sensitivity to negative emotions, although reduced accuracy in forced-choice paradigms more directly indicates impaired decoding rather than hypersensitivity. Second, substantial heterogeneity was markedly reduced only after exclusion of influential studies, raising concerns that pooled effects may be contingent on study selection and potentially reflect methodological compression. Third, meta-regression findings suggest that sample size and stimulus modality meaningfully influence effect estimates, underscoring design-related variability. Finally, cognitive status was not formally modeled as a moderator, despite its potential relevance to emotion recognition performance in late-life depression. We suggest that clearer differentiation between perceptual deficit and interpretative bias, alongside greater attention to methodological and cognitive moderators, would strengthen theoretical inference and future meta-analytic work in this domain.</p>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"360 ","pages":"117083"},"PeriodicalIF":3.9,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1016/j.psychres.2026.117082
Yuqi Cui, Wencan Wu, Zhiyong Liu, Jay J Shen, Xiaolei Ban, Ran Li, Jiajia Hu, Fanke Zhou, Junna Zhang, Xiaomin Lou, Xian Wang
Objective: Mental health in adolescents has been a growing problem in recent decades. However, comprehensive discussion of the research on the distal and proximal factors related to adolescent mental health were limited and the evidence was lacking. This study aimed to explore the result of adverse childhood experiences and biological rhythms for depressive and anxiety symptoms in adolescents.
Methods: The data used in this study were obtained from China in 2021 (as baseline) and 2023 (as follow-up). Participants provided self-reported information through an anonymous questionnaire. Logistic regression, cluster analysis, restriction cubic spline plots and receiver operating characteristic curves were used for statistical analysis.
Results: The study involved 2103 teenagers (mean age 15 years old), consisting of 1089 females and 1014 males. Multiple logistic regression results based on this subgroup showed that higher scores on either ACEs or biorhythms were associated with a greater risk of concurrent depressive-anxiety symptoms at baseline and follow-up, the adjusted ORs (95% CI) were 14.46 (7.14-29.26), 12.09 (5.83-22.08), respectively. The area under the receiver operating characteristic curve of the joint predictive effect of the ACEs and biorhythms were 0.664 for depressive symptoms, 0.656 for anxiety symptoms, and 0.667 for co-morbidity.
Conclusion: These findings emphasize the necessity of balancing past risk factors with emerging risk factors (biorhythms) in the precaution and management of adolescent depression and anxiety symptoms problems.
{"title":"Adverse childhood experiences and biological rhythms can predict the coexisting symptoms of depression and anxiety in adolescents.","authors":"Yuqi Cui, Wencan Wu, Zhiyong Liu, Jay J Shen, Xiaolei Ban, Ran Li, Jiajia Hu, Fanke Zhou, Junna Zhang, Xiaomin Lou, Xian Wang","doi":"10.1016/j.psychres.2026.117082","DOIUrl":"https://doi.org/10.1016/j.psychres.2026.117082","url":null,"abstract":"<p><strong>Objective: </strong>Mental health in adolescents has been a growing problem in recent decades. However, comprehensive discussion of the research on the distal and proximal factors related to adolescent mental health were limited and the evidence was lacking. This study aimed to explore the result of adverse childhood experiences and biological rhythms for depressive and anxiety symptoms in adolescents.</p><p><strong>Methods: </strong>The data used in this study were obtained from China in 2021 (as baseline) and 2023 (as follow-up). Participants provided self-reported information through an anonymous questionnaire. Logistic regression, cluster analysis, restriction cubic spline plots and receiver operating characteristic curves were used for statistical analysis.</p><p><strong>Results: </strong>The study involved 2103 teenagers (mean age 15 years old), consisting of 1089 females and 1014 males. Multiple logistic regression results based on this subgroup showed that higher scores on either ACEs or biorhythms were associated with a greater risk of concurrent depressive-anxiety symptoms at baseline and follow-up, the adjusted ORs (95% CI) were 14.46 (7.14-29.26), 12.09 (5.83-22.08), respectively. The area under the receiver operating characteristic curve of the joint predictive effect of the ACEs and biorhythms were 0.664 for depressive symptoms, 0.656 for anxiety symptoms, and 0.667 for co-morbidity.</p><p><strong>Conclusion: </strong>These findings emphasize the necessity of balancing past risk factors with emerging risk factors (biorhythms) in the precaution and management of adolescent depression and anxiety symptoms problems.</p>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"360 ","pages":"117082"},"PeriodicalIF":3.9,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-05DOI: 10.1016/j.psychres.2026.117057
Jeffrey D Shahidullah, James Custer, Oscar Widales-Benitez, Nazan Aksan, Carly Hatchell, D Jeffrey Newport, Karen Dineen Wagner, Eric A Storch, Cynthia Claassen, Amy Garrett, Irma T Ugalde, Wade Weber, Charles B Nemeroff, Paul J Rathouz
{"title":"Corrigendum to \"Establishing a training plan and estimating inter-rater reliability across the multi-site Texas Childhood Trauma Research Network\" [Psychiatry Research 323 (2023) 115168].","authors":"Jeffrey D Shahidullah, James Custer, Oscar Widales-Benitez, Nazan Aksan, Carly Hatchell, D Jeffrey Newport, Karen Dineen Wagner, Eric A Storch, Cynthia Claassen, Amy Garrett, Irma T Ugalde, Wade Weber, Charles B Nemeroff, Paul J Rathouz","doi":"10.1016/j.psychres.2026.117057","DOIUrl":"https://doi.org/10.1016/j.psychres.2026.117057","url":null,"abstract":"","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":" ","pages":"117057"},"PeriodicalIF":3.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-05DOI: 10.1016/j.psychres.2026.116940
Michael LeDuc, Julianne Cary, Cole Marvin, Sean M. Mitchell
Background
U.S. uniformed law enforcement officers’ (ULEOs’) intention to purchase firearms increased recently, coinciding with increasing suicide risk, but research in this area remains sparse. We examined firearm storage practices and attitudes among U.S. ULEOs and their relation to suicide ideation (SI) and suicide risk.
Method
Currently employed U.S. ULEOs (N = 271) completed a cross-sectional online-based survey in June and July 2023.
Results
On average, ULEOs “agree” with positive firearm statements. Regarding firearm storage practices, 54.6% always store a firearm at home, 35.2% always keep a firearm loaded, 35.2% always store their firearm with a locking device, and 50.2% always safely store firearms in a locked location. Higher SI was associated with lower odds of always storing a firearm at home, loaded, and in a secure location, whereas higher suicide risk was associated with lower odds of always storing a firearm at home and in a secure location.
Conclusion
ULEOs reported higher positive firearm attitudes and rates of always storing a firearm loaded and never using a locking device than other samples in the literature. Our findings highlight the importance of SI and suicide risk in safe firearm storage practices, which could aid in firearm death and suicide prevention efforts.
{"title":"Suicide ideation, suicide risk, and firearm storage practices and attitudes among U.S. uniformed law enforcement officers’","authors":"Michael LeDuc, Julianne Cary, Cole Marvin, Sean M. Mitchell","doi":"10.1016/j.psychres.2026.116940","DOIUrl":"10.1016/j.psychres.2026.116940","url":null,"abstract":"<div><h3>Background</h3><div>U.S. uniformed law enforcement officers’ (ULEOs’) intention to purchase firearms increased recently, coinciding with increasing suicide risk, but research in this area remains sparse. We examined firearm storage practices and attitudes among U.S. ULEOs and their relation to suicide ideation (SI) and suicide risk.</div></div><div><h3>Method</h3><div>Currently employed U.S. ULEOs (<em>N</em> = 271) completed a cross-sectional online-based survey in June and July 2023.</div></div><div><h3>Results</h3><div>On average, ULEOs “agree” with positive firearm statements. Regarding firearm storage practices, 54.6% always store a firearm at home, 35.2% always keep a firearm loaded, 35.2% always store their firearm with a locking device, and 50.2% always safely store firearms in a locked location. Higher SI was associated with lower odds of always storing a firearm at home, loaded, and in a secure location, whereas higher suicide risk was associated with lower odds of always storing a firearm at home and in a secure location.</div></div><div><h3>Conclusion</h3><div>ULEOs reported higher positive firearm attitudes and rates of always storing a firearm loaded and never using a locking device than other samples in the literature. Our findings highlight the importance of SI and suicide risk in safe firearm storage practices, which could aid in firearm death and suicide prevention efforts.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116940"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-16DOI: 10.1016/j.psychres.2025.116909
Gijsbrecht H.J. Roelandt , Jurriaan F.M. Strous , Radboud M. Marijnissen , Jeanine Kamphuis , Jens. H. van Dalfsen , Robert A. Schoevers
Aims
Ketamine has been shown to decrease suicidality in patients with depression. However, little is known about tolerability and efficacy in heterogenous, acutely suicidal patients in emergency settings. This pilot study aimed to assess the feasibility, acceptability, and safety of generic intranasal racemic ketamine (75 mg) in the treatment of acute suicidality regardless of the underlying diagnosis, as preparation for a subsequent double-blind randomized placebo-controlled trial (RCT).
Method
From September 2021 to June 2022, 12 patients with acute suicidality were recruited. All received a single open-label dose of 75 mg intranasal racemic ketamine. Suicidality was assessed with the Beck Scale for Suicidal Ideation (BSSI), depression with the Montgomery-Åsberg Depression Rating Scale (MADRS), side effects with the Systematic Assessment for Treatment Emergent Effects (SAFTEE) and Clinician Administered Dissociative Symptom Scale (CADSS), and overall improvement with the Clinical Global Impression (CGI) at 60 min, 180 min, and at 1, 3, and 7 days post-treatment. The CADSS and SAFTEE were administered only at baseline, 60 and 180 min post intervention. Vital signs were monitored for the first 240 min post intervention. Optional blood sampling occurred at baseline and 180 min post-treatment, and Magnetic Resonance Imaging one day post intervention.
Results
Treatment was well-tolerated. We observed a downward trend in both BSSI and MADRS scores one day post treatment, though this effect declined by day seven. One patient developed ketamine misuse several weeks after participation.
Conclusions
The treatment was generally feasible, well-tolerated and safe. Intranasal ketamine reduced acute suicidality in some cases but regarding efficacy, no definitive conclusions can be drawn from this pilot study. Amendments were made to the study protocol with extended follow-up time, investigation of drug liking and craving, less questionnaires and longer inclusion window.
{"title":"Single fixed-dose intranasal racemic ketamine treatment for the treatment of acute suicidality in a transdiagnostic patient population: Results of a pilot study","authors":"Gijsbrecht H.J. Roelandt , Jurriaan F.M. Strous , Radboud M. Marijnissen , Jeanine Kamphuis , Jens. H. van Dalfsen , Robert A. Schoevers","doi":"10.1016/j.psychres.2025.116909","DOIUrl":"10.1016/j.psychres.2025.116909","url":null,"abstract":"<div><h3>Aims</h3><div>Ketamine has been shown to decrease suicidality in patients with depression. However, little is known about tolerability and efficacy in heterogenous, acutely suicidal patients in emergency settings. This pilot study aimed to assess the feasibility, acceptability, and safety of generic intranasal racemic ketamine (75 mg) in the treatment of acute suicidality regardless of the underlying diagnosis, as preparation for a subsequent double-blind randomized placebo-controlled trial (RCT).</div></div><div><h3>Method</h3><div>From September 2021 to June 2022, 12 patients with acute suicidality were recruited. All received a single open-label dose of 75 mg intranasal racemic ketamine. Suicidality was assessed with the Beck Scale for Suicidal Ideation (BSSI), depression with the Montgomery-Åsberg Depression Rating Scale (MADRS), side effects with the Systematic Assessment for Treatment Emergent Effects (SAFTEE) and Clinician Administered Dissociative Symptom Scale (CADSS), and overall improvement with the Clinical Global Impression (CGI) at 60 min, 180 min, and at 1, 3, and 7 days post-treatment. The CADSS and SAFTEE were administered only at baseline, 60 and 180 min post intervention. Vital signs were monitored for the first 240 min post intervention. Optional blood sampling occurred at baseline and 180 min post-treatment, and Magnetic Resonance Imaging one day post intervention.</div></div><div><h3>Results</h3><div>Treatment was well-tolerated. We observed a downward trend in both BSSI and MADRS scores one day post treatment, though this effect declined by day seven. One patient developed ketamine misuse several weeks after participation.</div></div><div><h3>Conclusions</h3><div>The treatment was generally feasible, well-tolerated and safe. Intranasal ketamine reduced acute suicidality in some cases but regarding efficacy, no definitive conclusions can be drawn from this pilot study. Amendments were made to the study protocol with extended follow-up time, investigation of drug liking and craving, less questionnaires and longer inclusion window.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116909"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-22DOI: 10.1016/j.psychres.2025.116921
Magda Malewska-Kasprzak , Monika Dmitrzak-Weglarz , Filip Rybakowski
Bipolar disorder (BD) is a chronic psychiatric illness marked by recurrent manic and depressive episodes, with substantial disability and high comorbidity. Emerging evidence highlights purinergic signaling and cellular energy metabolism as convergent, interdependent drivers of BD pathophysiology. Purines—particularly adenosine and ATP—function dually as intracellular energy substrates and extracellular signaling molecules regulating neuroinflammation, neurotransmission, and redox balance. Dysregulation of purinergic pathways, including P2 × 7 receptor overactivation, elevated uric acid, and reduced neuroprotective adenosine, interacts with mitochondrial dysfunction—characterized by impaired oxidative phosphorylation, ATP depletion, increased reactive oxygen species, and redox imbalance—to form a pathological feedback loop. This bioenergetic–purinergic axis underlies mood cycling: mania reflecting bioenergetic upregulation with purinergic hyperactivity, and depression representing bioenergetic downregulation with purinergic hypoactivity.
Biomarkers such as uric acid, xanthine dehydrogenase and adenosine deaminase activity, phosphocreatine, ATP levels, and oxidative stress indices demonstrate phase-dependent alterations and hold promise for diagnosis, prognosis, and treatment monitoring. Therapeutic opportunities extend beyond conventional mood stabilizers to include xanthine oxidase inhibitors (e.g., allopurinol), P2 × 7 antagonists, adenosine modulators, and mitochondrial-supportive agents (e.g., creatine, carnitine, CoQ10, N-acetylcysteine). Integration of omics profiling, advanced neuroimaging, and biomarker-guided stratification may enable precision psychiatry approaches tailored to individual metabolic–inflammatory phenotypes.
This integrative model reframes BD as a systemic disorder of cellular energetics and purinergic signaling, offering novel mechanistic targets and guiding the development of personalized, phase-specific interventions to improve long-term outcomes.
{"title":"Purinergic signaling and energetic metabolism in bipolar disorder: From pathophysiology to precision therapeutics","authors":"Magda Malewska-Kasprzak , Monika Dmitrzak-Weglarz , Filip Rybakowski","doi":"10.1016/j.psychres.2025.116921","DOIUrl":"10.1016/j.psychres.2025.116921","url":null,"abstract":"<div><div>Bipolar disorder (BD) is a chronic psychiatric illness marked by recurrent manic and depressive episodes, with substantial disability and high comorbidity. Emerging evidence highlights purinergic signaling and cellular energy metabolism as convergent, interdependent drivers of BD pathophysiology. Purines—particularly adenosine and ATP—function dually as intracellular energy substrates and extracellular signaling molecules regulating neuroinflammation, neurotransmission, and redox balance. Dysregulation of purinergic pathways, including P2 × 7 receptor overactivation, elevated uric acid, and reduced neuroprotective adenosine, interacts with mitochondrial dysfunction—characterized by impaired oxidative phosphorylation, ATP depletion, increased reactive oxygen species, and redox imbalance—to form a pathological feedback loop. This bioenergetic–purinergic axis underlies mood cycling: mania reflecting bioenergetic upregulation with purinergic hyperactivity, and depression representing bioenergetic downregulation with purinergic hypoactivity.</div><div>Biomarkers such as uric acid, xanthine dehydrogenase and adenosine deaminase activity, phosphocreatine, ATP levels, and oxidative stress indices demonstrate phase-dependent alterations and hold promise for diagnosis, prognosis, and treatment monitoring. Therapeutic opportunities extend beyond conventional mood stabilizers to include xanthine oxidase inhibitors (e.g., allopurinol), P2 × 7 antagonists, adenosine modulators, and mitochondrial-supportive agents (e.g., creatine, carnitine, CoQ10, N-acetylcysteine). Integration of omics profiling, advanced neuroimaging, and biomarker-guided stratification may enable precision psychiatry approaches tailored to individual metabolic–inflammatory phenotypes.</div><div>This integrative model reframes BD as a systemic disorder of cellular energetics and purinergic signaling, offering novel mechanistic targets and guiding the development of personalized, phase-specific interventions to improve long-term outcomes.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116921"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-24DOI: 10.1016/j.psychres.2025.116924
Júlia Gisbert-Pérez, Adrián García-Mollá, José M. Tomás, Manuel Martí-Vilar, Laura Badenes-Ribera
Importance
Internet gaming disorder (IGD) has emerged as a growing concern, particularly among adolescents and young adults. This concern has prompted the development of standardized tools for IGD assessment, such as the Internet Gaming Disorder Scale (IGDS). IGDS is based on the DSM-V diagnostic criteria, and has been mainly used as a unidimensional measure of IGD.
Objective
This study aimed to translate and validate the Spanish version of the IGDS in a sample of university students (N = 274, Mage= 21.64 years, SDage = 2.93, % male = 59.7%).
Methods
Exploratory Graph Analysis (EGA) followed by Confirmatory Factor Analysis (CFA) were conducted, and internal consistency and convergent validity were assessed.
Results
EGA identified a bidimensional structure comprising (1) cognitive–emotional symptoms and (2) relational-problem outcomes, which was confirmed through CFA. Both dimensions demonstrated excellent reliability and adequate convergent validity.
Conclusion
The Spanish IGDS is a psychometrically valid instrument for assessing IGD, allowing for an accurate distinction between gaming intensity and functional impairment. These findings challenge the traditional unidimensional perspective and support a biaxial conceptualization of IGD.
{"title":"Factor structure of the Internet Gaming Disorder Scale: an Exploratory Graph Analysis approach in Spanish university gamers","authors":"Júlia Gisbert-Pérez, Adrián García-Mollá, José M. Tomás, Manuel Martí-Vilar, Laura Badenes-Ribera","doi":"10.1016/j.psychres.2025.116924","DOIUrl":"10.1016/j.psychres.2025.116924","url":null,"abstract":"<div><h3>Importance</h3><div>Internet gaming disorder (IGD) has emerged as a growing concern, particularly among adolescents and young adults. This concern has prompted the development of standardized tools for IGD assessment, such as the Internet Gaming Disorder Scale (IGDS). IGDS is based on the DSM-V diagnostic criteria, and has been mainly used as a unidimensional measure of IGD.</div></div><div><h3>Objective</h3><div>This study aimed to translate and validate the Spanish version of the IGDS in a sample of university students (<em>N</em> = 274, <em>M<sub>age</sub></em>= 21.64 years, <em>SD<sub>age</sub></em> = 2.93, % male = 59.7%).</div></div><div><h3>Methods</h3><div>Exploratory Graph Analysis (EGA) followed by Confirmatory Factor Analysis (CFA) were conducted, and internal consistency and convergent validity were assessed.</div></div><div><h3>Results</h3><div>EGA identified a bidimensional structure comprising (1) cognitive–emotional symptoms and (2) relational-problem outcomes, which was confirmed through CFA. Both dimensions demonstrated excellent reliability and adequate convergent validity.</div></div><div><h3>Conclusion</h3><div>The Spanish IGDS is a psychometrically valid instrument for assessing IGD, allowing for an accurate distinction between gaming intensity and functional impairment. These findings challenge the traditional unidimensional perspective and support a biaxial conceptualization of IGD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116924"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.psychres.2026.116949
Faisal Adi Irawan , Christina Yeni Kustanti , Koko Srimulyo , Rifky Octavia Pradipta , Nuzul Qur’aniati , Rika Sarfika , Lisa McKenna , Ferry Efendi
Introduction
Inhalant misuse, particularly glue sniffing, is one of the most harmful yet least studied forms of substance abuse among street-involved children. Despite high prevalence in some low- and middle-income countries (LMICs), research is limited, fragmented, and often embedded within broader substance use studies. This study aimed to map global research trends, identify thematic patterns, and highlight gaps in the literature on inhalant misuse among this population.
Methods
A bibliometric analysis was conducted using Scopus and Web of Science databases, searched on June 12, 2025 without date restrictions, guided by a Population–Concept–Context framework. Screening and data cleaning were performed by two reviewers. Eligible records were analyzed using Bibliometrix (Biblioshiny) to examine publication trends, authorship, journal sources, keyword co-occurrence, and thematic patterns.
Results
From 343 records, 161 articles (1989–2025) were included. Publications spanned 94 sources and 532 authors, with 5.55% annual growth and a mean 26.23 citations per document. International co-authorship was 11.8%. The United States contributed most, followed by Canada and Australia. The Journal of Adolescent Health was the top source; Substance Use & Misuse and Children and Youth Services Review also ranked highly. Eight keyword clusters were identified, led by terms including “homelessness adolescents,” “street children,” “HIV,” “substance abuse,” “alcohol,” “substance use,” “homelessness,” and “adolescents.”. Themes centered on abuse, risky behaviors, drug use, depression, and support, while socio-cultural and educational impacts in LMICs were notably sparse.
Conclusion
Inhalant misuse among street-involved children is an under-recognized global health and social issue. Strengthening interdisciplinary and geographically inclusive research can guide targeted interventions and policies aligned with Sustainable Development Goal (SDG) 3.5 on substance abuse prevention and treatment.
简介:滥用吸入剂,特别是吸胶,是街头儿童中最有害但研究最少的药物滥用形式之一。尽管在一些低收入和中等收入国家(LMICs)中发病率很高,但研究是有限的、零散的,而且往往被纳入更广泛的药物使用研究。本研究旨在绘制全球研究趋势,确定专题模式,并突出这一人群中吸入剂滥用的文献差距。方法:使用Scopus和Web of Science数据库进行文献计量学分析,检索日期为2025年6月12日,无日期限制,采用Population-Concept-Context框架。筛选和数据清理由两名审查员进行。使用Bibliometrix (Biblioshiny)分析符合条件的记录,以检查出版趋势、作者身份、期刊来源、关键词共现和主题模式。结果:共纳入343篇文献161篇(1989-2025)。出版物跨越94个来源和532位作者,年增长率为5.55%,平均每篇论文被引用26.23次。国际合作作者占11.8%。美国贡献最多,其次是加拿大和澳大利亚。《青少年健康杂志》是最主要的来源;《物质使用与滥用》和《儿童与青少年服务评论》的排名也很高。确定了八个关键字集群,其中包括“无家可归的青少年”、“街头儿童”、“艾滋病毒”、“药物滥用”、“酒精”、“药物使用”、“无家可归”和“青少年”。主题集中于虐待、危险行为、药物使用、抑郁和支持,而对中低收入国家的社会文化和教育影响明显较少。结论:街头儿童滥用吸入剂是一个未得到充分认识的全球健康和社会问题。加强跨学科和地域包容性研究可以指导有针对性的干预措施和政策,这些措施和政策符合关于预防和治疗药物滥用的可持续发展目标3.5。
{"title":"A bibliometric analysis of inhalant misuse among street-involved children: Trends, patterns, and research gaps","authors":"Faisal Adi Irawan , Christina Yeni Kustanti , Koko Srimulyo , Rifky Octavia Pradipta , Nuzul Qur’aniati , Rika Sarfika , Lisa McKenna , Ferry Efendi","doi":"10.1016/j.psychres.2026.116949","DOIUrl":"10.1016/j.psychres.2026.116949","url":null,"abstract":"<div><h3>Introduction</h3><div>Inhalant misuse, particularly glue sniffing, is one of the most harmful yet least studied forms of substance abuse among street-involved children. Despite high prevalence in some low- and middle-income countries (LMICs), research is limited, fragmented, and often embedded within broader substance use studies. This study aimed to map global research trends, identify thematic patterns, and highlight gaps in the literature on inhalant misuse among this population.</div></div><div><h3>Methods</h3><div>A bibliometric analysis was conducted using Scopus and Web of Science databases, searched on June 12, 2025 without date restrictions, guided by a Population–Concept–Context framework. Screening and data cleaning were performed by two reviewers. Eligible records were analyzed using Bibliometrix (Biblioshiny) to examine publication trends, authorship, journal sources, keyword co-occurrence, and thematic patterns.</div></div><div><h3>Results</h3><div>From 343 records, 161 articles (1989–2025) were included. Publications spanned 94 sources and 532 authors, with 5.55% annual growth and a mean 26.23 citations per document. International co-authorship was 11.8%. The United States contributed most, followed by Canada and Australia. The <em>Journal of Adolescent Health</em> was the top source; <em>Substance Use & Misuse</em> and <em>Children and Youth Services Review</em> also ranked highly. Eight keyword clusters were identified, led by terms including <em>“homelessness adolescents,” “street children,” “HIV,” “substance abuse,” “alcohol,” “substance use,” “homelessness,”</em> and <em>“adolescents.”</em>. Themes centered on abuse, risky behaviors, drug use, depression, and support, while socio-cultural and educational impacts in LMICs were notably sparse.</div></div><div><h3>Conclusion</h3><div>Inhalant misuse among street-involved children is an under-recognized global health and social issue. Strengthening interdisciplinary and geographically inclusive research can guide targeted interventions and policies aligned with Sustainable Development Goal (SDG) 3.5 on substance abuse prevention and treatment.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116949"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1016/j.psychres.2026.116946
Mateus Eduardo Romão , Giacomo Belli , Rebeca Gomes de Oliveira , Valentina Sommovigo , Silvia Damiana Visonà , Simone Scoccianti , Ilaria Setti , Makilim Nunes Baptista , Serena Barello
Background
Veterinarians experience one of the highest suicide rates of any profession. Beyond fatalities, growing evidence documents suicidal ideation and non-fatal attempts, but findings are fragmented.
Objective
To map risk and protective factors for suicidal behavior—including ideation, attempts, and death among licensed veterinarians.
Methods
Following Joanna Briggs Institute guidance and PRISMA-ScR reporting standards, we searched PubMed, Scopus, Web of Science, PsycINFO, and CINAHL (2009–2024). Eligible studies examined empirical associations between any risk or protective factor and suicidal outcomes in veterinarians. Data were extracted on study design, sample, country, outcome, and key findings.
Results
Twelve studies from six countries met inclusion criteria (nine cross-sectional surveys, one qualitative interview study, one focus-group study, one retrospective mortality analysis). Suicide risk reflected the convergence of occupational stressors (workload, client conflict, euthanasia), psychological vulnerabilities (depression, perfectionism, burnout), demographic variables (gender, early-career status), and access to lethal means (particularly pentobarbital). Protective elements included peer and social support, job satisfaction, adaptive coping, and indirect secure storage of euthanasia agents. Evidence was limited by the predominance of cross-sectional self-report designs and by restricted geographic coverage.
Conclusions
Veterinarians face distinctive pressures that heighten the risk of suicidal ideation, attempts, and death. Multi-level strategies, such as supportive work environments, coping-skills training, peer-support programs, and evaluation of means-restriction policies, should be prioritized. Further longitudinal and cross-national studies are needed to clarify risk trajectories and strengthen preventive action.
兽医是所有职业中自杀率最高的职业之一。除了死亡之外,越来越多的证据记录了自杀意念和非致命企图,但研究结果是零散的。目的了解执业兽医自杀行为的危险因素和保护因素,包括自杀意念、企图和死亡。方法按照Joanna Briggs Institute的指导和PRISMA-ScR报告标准,检索PubMed、Scopus、Web of Science、PsycINFO和CINAHL(2009-2024)。符合条件的研究考察了兽医中任何风险或保护因素与自杀结果之间的经验关联。从研究设计、样本、国家、结果和主要发现等方面提取数据。结果来自6个国家的12项研究符合纳入标准(9项横断面调查、1项定性访谈研究、1项焦点小组研究、1项回顾性死亡率分析)。自杀风险反映了职业压力源(工作量、客户冲突、安乐死)、心理脆弱性(抑郁、完美主义、倦怠)、人口统计学变量(性别、早期职业状态)和致命手段(尤其是戊巴比妥)的趋同。保护因素包括同伴和社会支持、工作满意度、适应性应对和安乐死药剂的间接安全储存。证据受限于横断面自我报告设计的优势和有限的地理覆盖。兽医面临着独特的压力,这些压力增加了自杀意念、企图和死亡的风险。应优先考虑诸如支持性工作环境、应对技能培训、同伴支持计划和经济限制政策评估等多层次策略。需要进一步进行纵向和跨国研究,以澄清风险轨迹并加强预防行动。
{"title":"Understanding the roots of suicide in veterinarians to inform prevention: A scoping review","authors":"Mateus Eduardo Romão , Giacomo Belli , Rebeca Gomes de Oliveira , Valentina Sommovigo , Silvia Damiana Visonà , Simone Scoccianti , Ilaria Setti , Makilim Nunes Baptista , Serena Barello","doi":"10.1016/j.psychres.2026.116946","DOIUrl":"10.1016/j.psychres.2026.116946","url":null,"abstract":"<div><h3>Background</h3><div>Veterinarians experience one of the highest suicide rates of any profession. Beyond fatalities, growing evidence documents suicidal ideation and non-fatal attempts, but findings are fragmented.</div></div><div><h3>Objective</h3><div>To map risk and protective factors for suicidal behavior—including ideation, attempts, and death among licensed veterinarians.</div></div><div><h3>Methods</h3><div>Following Joanna Briggs Institute guidance and PRISMA-ScR reporting standards, we searched PubMed, Scopus, Web of Science, PsycINFO, and CINAHL (2009–2024). Eligible studies examined empirical associations between any risk or protective factor and suicidal outcomes in veterinarians. Data were extracted on study design, sample, country, outcome, and key findings.</div></div><div><h3>Results</h3><div>Twelve studies from six countries met inclusion criteria (nine cross-sectional surveys, one qualitative interview study, one focus-group study, one retrospective mortality analysis). Suicide risk reflected the convergence of occupational stressors (workload, client conflict, euthanasia), psychological vulnerabilities (depression, perfectionism, burnout), demographic variables (gender, early-career status), and access to lethal means (particularly pentobarbital). Protective elements included peer and social support, job satisfaction, adaptive coping, and indirect secure storage of euthanasia agents. Evidence was limited by the predominance of cross-sectional self-report designs and by restricted geographic coverage.</div></div><div><h3>Conclusions</h3><div>Veterinarians face distinctive pressures that heighten the risk of suicidal ideation, attempts, and death. Multi-level strategies, such as supportive work environments, coping-skills training, peer-support programs, and evaluation of means-restriction policies, should be prioritized. Further longitudinal and cross-national studies are needed to clarify risk trajectories and strengthen preventive action.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116946"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}