Psychiatry Research最新文献

英文中文

Reducing mental health distress and preventing depression in young people in the community: A multimethod observational study with a real-world and prospective 12-month controlled approach 减少社区年轻人的心理健康困扰和预防抑郁症：一项多方法观察性研究，采用现实世界和前瞻性12个月的对照方法：社区年轻人的心理健康困扰。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116279

Christy Lai-Ming Hui , Eric Yu-Hai Chen , Stephanie Ming-Yin Wong , Gloria Hoi-Yan Wong , Sherry Kit-Wa Chan , Pak-Chung Sham , Michael Tak-Hing Wong , Kai-Tai Chan , Charlton Cheung , Gabriel Chun-Hei Lai , Debra Rickwood , Patrick D Mcgorry , Yi-Nam Suen

Community-based youth mental health (YMH) platforms are challenging to evaluate. Using a multi-method approach, we examined the efficacy of an integrated YMH program in Hong Kong. The real-world outcomes of 1047 participants were compared with a propensity score (PS) matched control group randomly selected from the community (study 1). In a separate prospective 12-month study, a sample of up to 133 matched pairs of YMH and controls were compared for more detailed symptomatic and functional outcomes (study 2). Study 1 revealed that the YMH program was associated with a significant reduction in distress. A higher proportion of YMH participants improved, and fewer deteriorated compared with controls. The YMH program also translated into a net reduction of 1.28 % in the risk of common disorders. Study 2 revealed that the YMH program showed significant reductions in depressive symptoms, anxiety symptoms, distress, and functioning after 12 months. The two complementary studies, using PS-matched controlled comparisons, enabled the sample representativeness and the comprehensive examination of the longitudinal impact. This YMH program reduces current distress, symptoms, and functional impairment, and prevents the emergence of probable mental disorder. Findings have significant implications for developing and evaluating future YMH services.

基于社区的青年心理健康（YMH）平台的评估具有挑战性。采用多种方法，我们考察了香港综合青年健康计划的效果。将1047名参与者的真实结果与从社区随机选择的倾向评分（PS）匹配的对照组进行比较（研究1）。在一项单独的12个月前瞻性研究中，对多达133对匹配的YMH和对照样本进行了更详细的症状和功能结果比较（研究2）。研究1显示，YMH计划与显著减少痛苦有关。与对照组相比，更高比例的YMH参与者改善了，更少的人恶化了。yh项目还转化为常见疾病风险净降低1.28%。研究2显示，YMH项目在12个月后显著减少了抑郁症状、焦虑症状、痛苦和功能。两项互补研究，采用ps匹配对照比较，使样本代表性和纵向影响的全面检查。这个YMH项目减少了当前的痛苦、症状和功能损害，并防止可能出现的精神障碍。研究结果对发展和评估未来的YMH服务具有重要意义。

{"title":"Reducing mental health distress and preventing depression in young people in the community: A multimethod observational study with a real-world and prospective 12-month controlled approach","authors":"Christy Lai-Ming Hui , Eric Yu-Hai Chen , Stephanie Ming-Yin Wong , Gloria Hoi-Yan Wong , Sherry Kit-Wa Chan , Pak-Chung Sham , Michael Tak-Hing Wong , Kai-Tai Chan , Charlton Cheung , Gabriel Chun-Hei Lai , Debra Rickwood , Patrick D Mcgorry , Yi-Nam Suen","doi":"10.1016/j.psychres.2024.116279","DOIUrl":"10.1016/j.psychres.2024.116279","url":null,"abstract":"<div><div>Community-based youth mental health (YMH) platforms are challenging to evaluate. Using a multi-method approach, we examined the efficacy of an integrated YMH program in Hong Kong. The real-world outcomes of 1047 participants were compared with a propensity score (PS) matched control group randomly selected from the community (study 1). In a separate prospective 12-month study, a sample of up to 133 matched pairs of YMH and controls were compared for more detailed symptomatic and functional outcomes (study 2). Study 1 revealed that the YMH program was associated with a significant reduction in distress. A higher proportion of YMH participants improved, and fewer deteriorated compared with controls. The YMH program also translated into a net reduction of 1.28 % in the risk of common disorders. Study 2 revealed that the YMH program showed significant reductions in depressive symptoms, anxiety symptoms, distress, and functioning after 12 months. The two complementary studies, using PS-matched controlled comparisons, enabled the sample representativeness and the comprehensive examination of the longitudinal impact. This YMH program reduces current distress, symptoms, and functional impairment, and prevents the emergence of probable mental disorder. Findings have significant implications for developing and evaluating future YMH services.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116279"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decisional capacity to consent to treatment in children and adolescents: A systematic review 儿童和青少年同意治疗的决策能力：系统综述。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116343

Giovanna Parmigiani , Marcello Benevento , Biagio Solarino , Anna Margari , Davide Ferorelli , Luigi Buongiorno , Roberto Catanesi , Felice Carabellese , Antonio Del Casale , Stefano Ferracuti , Gabriele Mandarelli

Obtaining informed consent in vulnerable populations like children and adolescents, is a relevant issue and raises ethical concerns. Minors are considered unable to consent to treatment, and permission from guardians is required for them. Nevertheless, several studies have been carried out on the competence of pediatric patients, with mixed results. Following PRISMA guidelines, a systematic review was performed to assess children and adolescents’ decisional capacity to consent to treatment. The search strategy identified 2,790 studies, including 10 that survived full-text screening and evaluation. Studies included in the analysis evaluated the decision-making capacity of minors using the MacArthur Competency Assessment Tool - Treatment (MacCAT-T), the Adolescent Psychiatric Patient Competency Questionnaire (CQ-ChP); the Measure of Competency (MOC), the Measure of Competency- Hypothetical (MOCHyp). Overall, minors over the age of 13 showed an acceptable decisional capacity. However, further research, preferably on larger groups, is needed to shed more light on this topic.

在儿童和青少年等弱势群体中获得知情同意是一个相关问题，并引发了伦理问题。未成年人被认为不能同意治疗，需要监护人的许可。然而，一些关于儿科患者能力的研究结果好坏参半。遵循PRISMA指南，进行了系统评价，以评估儿童和青少年同意治疗的决策能力。搜索策略确定了2790项研究，其中10项通过了全文筛选和评估。本研究采用麦克阿瑟能力评估工具-治疗（MacCAT-T）、青少年精神病患者能力问卷（CQ-ChP）评估未成年人的决策能力；能力测量（MOC），能力测量-假设（MOCHyp）。总体而言，13岁以上的未成年人表现出可接受的决策能力。然而，需要进一步的研究，最好是在更大的群体中，来阐明这个主题。

{"title":"Decisional capacity to consent to treatment in children and adolescents: A systematic review","authors":"Giovanna Parmigiani , Marcello Benevento , Biagio Solarino , Anna Margari , Davide Ferorelli , Luigi Buongiorno , Roberto Catanesi , Felice Carabellese , Antonio Del Casale , Stefano Ferracuti , Gabriele Mandarelli","doi":"10.1016/j.psychres.2024.116343","DOIUrl":"10.1016/j.psychres.2024.116343","url":null,"abstract":"<div><div>Obtaining informed consent in vulnerable populations like children and adolescents, is a relevant issue and raises ethical concerns. Minors are considered unable to consent to treatment, and permission from guardians is required for them. Nevertheless, several studies have been carried out on the competence of pediatric patients, with mixed results. Following PRISMA guidelines, a systematic review was performed to assess children and adolescents’ decisional capacity to consent to treatment. The search strategy identified 2,790 studies, including 10 that survived full-text screening and evaluation. Studies included in the analysis evaluated the decision-making capacity of minors using the MacArthur Competency Assessment Tool - Treatment (MacCAT-T), the Adolescent Psychiatric Patient Competency Questionnaire (CQ-ChP); the Measure of Competency (MOC), the Measure of Competency- Hypothetical (MOC<img>Hyp). Overall, minors over the age of 13 showed an acceptable decisional capacity. However, further research, preferably on larger groups, is needed to shed more light on this topic.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116343"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociative episodes and concurrent heart rate in patients with PTSD – An ecological momentary assessment 创伤后应激障碍患者的分离性发作和并发心率--生态瞬间评估。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116345

Sarah Beutler-Traktovenko , Marcel Franz , Judith Daniels , Julia Schellong , Kerstin Weidner , Ilona Croy

Dissociative symptoms are a frequent complication in posttraumatic stress disorders affecting about a third of all PTSD patients. While theoretical models predict a physiological hypoarousal during posttraumatic dissociations, empirical evidence is lacking. We addressed this by studying spontaneously occurring dissociative symptoms and related heart rate changes in an ecological momentary assessment. Therefore, we continuously measured heart rate for five to ten days with mobile ECG in 47 female inpatients diagnosed with posttraumatic stress disorder and dissociative symptoms. During this observation period, patients tracked each dissociative event on a smartphone app and reported on symptom characteristics.

Patients reported a total of 164 dissociative events. Those typically lasted <30 min and involved co-occuring depersonalization and derealization of moderate to severe intensity. Tracked symptoms correlated positively with some conventional self-reports for depersonalization and derealization. Heart rate during dissociative symptoms varied greatly between and within individuals and was on average not different from baseline assessment. There was also no significant relation between dissociation intensity and heart rate change.

These results challenge the theory of reactive hypoarousal during chronic dissociation and support the view that physiological adaptation modifies in the course of posttraumatic chronification. They also highlight the individual variability of dissociative symptoms and underscore the necessity of detailed assessment for targeted therapeutic approaches.

分离症状是创伤后应激障碍的常见并发症，约占所有创伤后应激障碍患者的三分之一。虽然理论模型预测了创伤后分离期间的生理低唤醒，但缺乏经验证据。我们通过研究自发发生的分离症状和相关的心率变化在生态瞬间评估来解决这个问题。因此，我们用移动心电图连续测量47名诊断为创伤后应激障碍和分离症状的住院女性患者的心率5至10天。在此观察期间，患者在智能手机应用程序上跟踪每个分离事件，并报告症状特征。患者总共报告了164次分离事件。这些通常会持续下去

{"title":"Dissociative episodes and concurrent heart rate in patients with PTSD – An ecological momentary assessment","authors":"Sarah Beutler-Traktovenko , Marcel Franz , Judith Daniels , Julia Schellong , Kerstin Weidner , Ilona Croy","doi":"10.1016/j.psychres.2024.116345","DOIUrl":"10.1016/j.psychres.2024.116345","url":null,"abstract":"<div><div>Dissociative symptoms are a frequent complication in posttraumatic stress disorders affecting about a third of all PTSD patients. While theoretical models predict a physiological hypoarousal during posttraumatic dissociations, empirical evidence is lacking. We addressed this by studying spontaneously occurring dissociative symptoms and related heart rate changes in an ecological momentary assessment. Therefore, we continuously measured heart rate for five to ten days with mobile ECG in 47 female inpatients diagnosed with posttraumatic stress disorder and dissociative symptoms. During this observation period, patients tracked each dissociative event on a smartphone app and reported on symptom characteristics.</div><div>Patients reported a total of 164 dissociative events. Those typically lasted <30 min and involved co-occuring depersonalization and derealization of moderate to severe intensity. Tracked symptoms correlated positively with some conventional self-reports for depersonalization and derealization. Heart rate during dissociative symptoms varied greatly between and within individuals and was on average not different from baseline assessment. There was also no significant relation between dissociation intensity and heart rate change.</div><div>These results challenge the theory of reactive hypoarousal during chronic dissociation and support the view that physiological adaptation modifies in the course of posttraumatic chronification. They also highlight the individual variability of dissociative symptoms and underscore the necessity of detailed assessment for targeted therapeutic approaches.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116345"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI in substance use recovery: Innovation or risk? A call for caution 人工智能在药物使用康复中的应用：创新还是风险？请谨慎行事。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116193

Erfan Ramadhani , Ramtia Darma Putri , Vasco Delano , M．Taheri Akhbar , Erdiansyah Erdiansyah , Muhammad Kurniawan

引用次数: 0

Maternal vitamin B12 during pregnancy and schizophrenia in offspring 孕期母体维生素 B12 与后代的精神分裂症。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116284

Andre Sourander , Sanju Silwal , Heljä-Marja Surcel , Susanna Hinkka-Yli-Salomäki , Keely Cheslack-Postava , Subina Upadhyaya , Ian W. McKeague , Alan S. Brown

Background

Maternal nutritional deficiency is linked with several adverse outcomes in offspring but the link between maternal vitamin B12 levels and offspring schizophrenia remains unexplored.

Methods

In this nationwide population-based nested case-control design, 1145 schizophrenia cases were born between 1987-1997 and diagnosed by 2017 and each case were matched with a control. Maternal vitamin B12 levels during the first and early second trimesters of pregnancy were measured using chemiluminescence microparticle immunoassay from maternal sera. Conditional logistic regression was used to examine the association between maternal vitamin B12 levels and offspring schizophrenia.

Results

Low maternal vitamin B12 levels were not associated with offspring schizophrenia in unadjusted (OR 1.04, 95% CI 0.88-1.24) or adjusted analyses (aOR 1.14, 95% CI 0.95-1.37). When analyzed by quintiles, no significant association was observed between the lowest versus highest quintile of maternal vitamin B12 levels and schizophrenia in unadjusted (OR 1.01, 95% CI 0.78-1.30) or adjusted analyses (OR 0.89, 95% CI 0.68-1.17).

Conclusion

Maternal vitamin B12 levels in early pregnancy were not associated with offspring schizophrenia. Future studies measuring both genetic and environmental factors are required to elucidate the role of maternal vitamin B12 deficiency in schizophrenia and its potential pathways to influence schizophrenia in offspring.

背景：母体营养缺乏与后代的多种不良后果有关，但母体维生素 B12 水平与后代精神分裂症之间的联系仍未得到研究：母体营养缺乏与后代的多种不良后果有关，但母体维生素B12水平与后代精神分裂症之间的联系仍未得到探讨：在这项基于全国人口的巢式病例对照设计中，1145例精神分裂症病例出生于1987-1997年间，并在2017年之前确诊，每例病例均与对照组匹配。采用化学发光微粒子免疫测定法测定了妊娠头三个月和后三个月早期母体血清中的维生素 B12 水平。结果发现，母体维生素 B12 水平低与子代精神分裂症之间的关系并不明显：在未调整分析（OR 1.04，95% CI 0.88-1.24）或调整分析（aOR 1.14，95% CI 0.95-1.37）中，母体维生素 B12 水平低与后代精神分裂症无关。如果按五分位数进行分析，在未调整分析（OR 1.01，95% CI 0.78-1.30）或调整分析（OR 0.89，95% CI 0.68-1.17）中，均未观察到母亲维生素 B12 水平最低五分位数与最高五分位数与精神分裂症之间存在显著关联：结论：孕早期母体维生素 B12 水平与后代精神分裂症无关。未来的研究需要同时测量遗传和环境因素，以阐明母体维生素B12缺乏在精神分裂症中的作用及其影响后代精神分裂症的潜在途径。

{"title":"Maternal vitamin B12 during pregnancy and schizophrenia in offspring","authors":"Andre Sourander , Sanju Silwal , Heljä-Marja Surcel , Susanna Hinkka-Yli-Salomäki , Keely Cheslack-Postava , Subina Upadhyaya , Ian W. McKeague , Alan S. Brown","doi":"10.1016/j.psychres.2024.116284","DOIUrl":"10.1016/j.psychres.2024.116284","url":null,"abstract":"<div><h3>Background</h3><div>Maternal nutritional deficiency is linked with several adverse outcomes in offspring but the link between maternal vitamin B12 levels and offspring schizophrenia remains unexplored.</div></div><div><h3>Methods</h3><div>In this nationwide population-based nested case-control design, 1145 schizophrenia cases were born between 1987-1997 and diagnosed by 2017 and each case were matched with a control. Maternal vitamin B12 levels during the first and early second trimesters of pregnancy were measured using chemiluminescence microparticle immunoassay from maternal sera. Conditional logistic regression was used to examine the association between maternal vitamin B12 levels and offspring schizophrenia.</div></div><div><h3>Results</h3><div>Low maternal vitamin B12 levels were not associated with offspring schizophrenia in unadjusted (OR 1.04, 95% CI 0.88-1.24) or adjusted analyses (aOR 1.14, 95% CI 0.95-1.37). When analyzed by quintiles, no significant association was observed between the lowest versus highest quintile of maternal vitamin B12 levels and schizophrenia in unadjusted (OR 1.01, 95% CI 0.78-1.30) or adjusted analyses (OR 0.89, 95% CI 0.68-1.17).</div></div><div><h3>Conclusion</h3><div>Maternal vitamin B12 levels in early pregnancy were not associated with offspring schizophrenia. Future studies measuring both genetic and environmental factors are required to elucidate the role of maternal vitamin B12 deficiency in schizophrenia and its potential pathways to influence schizophrenia in offspring.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116284"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19′s silent scars: The urgent link between SARS-CoV-2 infection and long-term mental health consequences COVID-19 的无声伤疤：SARS-CoV-2感染与长期精神健康后果之间的紧急联系。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116322

Yun Xie , Jiajun Wu , Shun Zhu , Ruilan Wang

引用次数: 0

The use of Experience Sampling Method in psychopharmacological studies: A systematic review 经验抽样法在精神药理学研究中的应用：系统综述。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116327

Davy Quadackers , Fionneke Bos , Johanna Hovenkamp-Hermelink , Danielle Cath , Harriëtte Riese

The Experience Sampling Method (ESM) is increasingly used to validate and assess treatment effects. We conducted a systematic review to update, and extend, the previous review by Bos et al. (2015), by performing literature searches in PubMed, PsycInfo, and EMBASE. Search queries included every DSM-disorder, ATC-listed psychotropic medication, and multiple search-terms for ESM. Studies included medicated psychiatric patients who filled-out ambulatory prompts ≥2/day. Templates served to distil research themes. The majority of the 79 included studies involved substance use- (n = 47), mood- (n = 17), and psychotic disorders (n = 11). Less studied were anxiety disorders and PTSD (n = 3), and ADHD (n = 1). We identified six research themes:1)Effects of psychopharmacological treatment on symptoms and factors influencing outcome, 2)Fluctuations of psychiatric symptoms in medicated patients, 3)Prediction of relapse, exacerbation of symptoms or medication non-compliance, 4)Added value of ESM compared to care as usual, 5)Using ESM to establish treatment response-trajectories, 6)Acceptability and feasibility of newly-devised ESM-applications. This review reveals that ESM is predominantly used in psychopharmacological studies to monitor treatment effects and establish fluctuations of momentary psychiatric symptoms. Future research might facilitate personalising psychopharmacological prescribing decisions using ESM. Currently underrepresented patient groups include elderly patients, and personality disorders. Finally, to facilitate ESM-implementation multiple context-levels should be optimised.

经验抽样法（ESM）越来越多地用于验证和评估治疗效果。通过在PubMed、PsycInfo和EMBASE中进行文献检索，我们进行了一项系统综述，以更新和扩展Bos等人（2015）的先前综述。搜索查询包括每一种dsm障碍，atc列出的精神药物，以及ESM的多个搜索词。研究纳入了每天填写门诊提示≥2次的接受药物治疗的精神病患者。模板用来提炼研究主题。纳入的79项研究中，大多数涉及物质使用（n = 47）、情绪（n = 17）和精神障碍（n = 11）。研究较少的是焦虑症和创伤后应激障碍（n = 3）和多动症（n = 1）。我们确定了六个研究主题：1)精神药物治疗对症状和影响结果的因素的影响，2)服药患者精神症状的波动，3)复发、症状加重或药物不依从性的预测，4)与常规护理相比，ESM的附加价值，5)使用ESM建立治疗反应轨迹。6)新设计的esm应用的可接受性和可行性。这篇综述表明，ESM主要用于精神药理学研究，以监测治疗效果和建立瞬间精神症状的波动。未来的研究可能会促进使用ESM的个性化精神药理学处方决策。目前代表性不足的患者群体包括老年患者和人格障碍患者。最后，为了促进esm的实施，应该优化多个上下文级别。

{"title":"The use of Experience Sampling Method in psychopharmacological studies: A systematic review","authors":"Davy Quadackers , Fionneke Bos , Johanna Hovenkamp-Hermelink , Danielle Cath , Harriëtte Riese","doi":"10.1016/j.psychres.2024.116327","DOIUrl":"10.1016/j.psychres.2024.116327","url":null,"abstract":"<div><div>The Experience Sampling Method (ESM) is increasingly used to validate and assess treatment effects. We conducted a systematic review to update, and extend, the previous review by Bos et al. (2015), by performing literature searches in PubMed, PsycInfo, and EMBASE. Search queries included every DSM-disorder, ATC-listed psychotropic medication, and multiple search-terms for ESM. Studies included medicated psychiatric patients who filled-out ambulatory prompts ≥2/day. Templates served to distil research themes. The majority of the 79 included studies involved substance use- (<em>n</em> = 47), mood- (<em>n</em> = 17), and psychotic disorders (<em>n</em> = 11). Less studied were anxiety disorders and PTSD (<em>n</em> = 3), and ADHD (<em>n</em> = 1). We identified six research themes:1)Effects of psychopharmacological treatment on symptoms and factors influencing outcome, 2)Fluctuations of psychiatric symptoms in medicated patients, 3)Prediction of relapse, exacerbation of symptoms or medication non-compliance, 4)Added value of ESM compared to care as usual, 5)Using ESM to establish treatment response-trajectories, 6)Acceptability and feasibility of newly-devised ESM-applications. This review reveals that ESM is predominantly used in psychopharmacological studies to monitor treatment effects and establish fluctuations of momentary psychiatric symptoms. Future research might facilitate personalising psychopharmacological prescribing decisions using ESM. Currently underrepresented patient groups include elderly patients, and personality disorders. Finally, to facilitate ESM-implementation multiple context-levels should be optimised.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116327"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of multiple non-invasive brain stimulation to treat major depressive disorder in older patients: A systematic review and network meta-analysis study based on randomized controlled trials 多次无创脑刺激治疗老年患者重度抑郁症的比较疗效：基于随机对照试验的系统评价和网络荟萃分析研究

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116340

Yang Yang , Jianglin Chen , Min Yu , Cheng Xiong , Rong Zhang , Guohui Jiang

Background

Major depressive disorder (MDD) is prevalent among older patients and is frequently associated with cognitive decline and a reduced quality of life. Non-invasive brain stimulation (NIBS) techniques show promise for treating MDD, but their comparative efficacy and safety older populations remain unclear. This study aimed to compare the efficacy and cognitive effects of various NIBS techniques in treating MDD in older patients.

Methods

We searched the PubMed, EMBASE, Cochrane Library, and Web of Science core databases from inception to March 2024. Seventeen randomized controlled trials (RCTs) were included.

Results

Surfaces under the cumulative ranking curve (SUCRA) values were used to rank the interventions. The SUCRA rankings for the Hamilton Depression Rating Scale (HDRS) outcomes indicated that repetitive transcranial magnetic stimulation (rTMS) (89.0 %) had the highest efficacy, followed by transcranial direct current stimulation (tDCS) (68.7 %). rTMS demonstrated significantly superior efficacy compared with bilateral electroconvulsive therapy (BL ECT) and right unilateral electroconvulsive therapy (RUL ECT). Theta burst stimulation (TBS) had the highest response rate (69.6 %), followed by rTMS (61.8 %). Based on the Mini-Mental State Examination, rTMS (86.4 %) ranked the highest, with RUL ECT showing significantly better outcomes than BL ECT.

Conclusion

NIBS, particularly rTMS and TBS, may offer effective treatment options for older patients with MDD. Further research with larger sample sizes and longer follow-up periods is required to validate these findings and inform clinical practice.

背景：重度抑郁症（MDD）在老年患者中普遍存在，通常与认知能力下降和生活质量下降有关。非侵入性脑刺激（NIBS）技术显示出治疗重度抑郁症的希望，但其相对疗效和老年人的安全性仍不清楚。本研究旨在比较不同NIBS技术治疗老年重度抑郁症的疗效和认知效果。方法：检索PubMed、EMBASE、Cochrane Library和Web of Science核心数据库，检索时间为建库至2024年3月。纳入17项随机对照试验（RCTs）。结果：采用累积排序曲线下曲面（SUCRA）值对干预措施进行排序。汉密尔顿抑郁评定量表（HDRS）结果的SUCRA排名显示，重复经颅磁刺激（rTMS）（89.0%）的疗效最高，其次是经颅直流电刺激（tDCS）（68.7%）。与双侧电惊厥治疗（BL ECT）和右侧单侧电惊厥治疗（RUL ECT）相比，rTMS的疗效显著优于rTMS。θ波爆发刺激（TBS）的反应率最高（69.6%），rTMS次之（61.8%）。基于迷你精神状态检查，rTMS（86.4%）排名最高，RUL ECT的疗效明显优于BL ECT。结论：NIBS，特别是rTMS和TBS，可能为老年MDD患者提供有效的治疗选择。进一步的研究需要更大的样本量和更长的随访期来验证这些发现并为临床实践提供信息。

{"title":"Comparative efficacy of multiple non-invasive brain stimulation to treat major depressive disorder in older patients: A systematic review and network meta-analysis study based on randomized controlled trials","authors":"Yang Yang , Jianglin Chen , Min Yu , Cheng Xiong , Rong Zhang , Guohui Jiang","doi":"10.1016/j.psychres.2024.116340","DOIUrl":"10.1016/j.psychres.2024.116340","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is prevalent among older patients and is frequently associated with cognitive decline and a reduced quality of life. Non-invasive brain stimulation (NIBS) techniques show promise for treating MDD, but their comparative efficacy and safety older populations remain unclear. This study aimed to compare the efficacy and cognitive effects of various NIBS techniques in treating MDD in older patients.</div></div><div><h3>Methods</h3><div>We searched the PubMed, EMBASE, Cochrane Library, and Web of Science core databases from inception to March 2024. Seventeen randomized controlled trials (RCTs) were included.</div></div><div><h3>Results</h3><div>Surfaces under the cumulative ranking curve (SUCRA) values were used to rank the interventions. The SUCRA rankings for the Hamilton Depression Rating Scale (HDRS) outcomes indicated that repetitive transcranial magnetic stimulation (rTMS) (89.0 %) had the highest efficacy, followed by transcranial direct current stimulation (tDCS) (68.7 %). rTMS demonstrated significantly superior efficacy compared with bilateral electroconvulsive therapy (BL ECT) and right unilateral electroconvulsive therapy (RUL ECT). Theta burst stimulation (TBS) had the highest response rate (69.6 %), followed by rTMS (61.8 %). Based on the Mini-Mental State Examination, rTMS (86.4 %) ranked the highest, with RUL ECT showing significantly better outcomes than BL ECT.</div></div><div><h3>Conclusion</h3><div>NIBS, particularly rTMS and TBS, may offer effective treatment options for older patients with MDD. Further research with larger sample sizes and longer follow-up periods is required to validate these findings and inform clinical practice.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116340"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unipolar mania over the course of a 15-year follow-up study 一项为期15年的随访研究。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116348

Hua-Meng Shi , De-Gua Jiang

Objective

A proportion of patients with bipolar disorder (BD) manifests with only Unipolar mania (UM). We conducted a follow-up study of patients diagnosed with Unipolar mania and compared them as a group if they had a mild depressive episode with those who did not.

Method

248 subjects were prospectively followed-up to 15 years. During the 15-year follow-up study, Pure mania was defined as patients who did not experience mild depressive episodes(203) and Mania with mild depression was defined as patients who did experience mild depressive episodes(45). Then, we compare characterization of clinical features between Pure mania (PM) and Mania with mild depression (MMD).

Results

Compared with the Mania with mild depression group, the Pure mania group had more psychotic symptoms, fewer suicidal behaviors, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Substantially different lifetime comorbidity patterns were observed between the two groups.

Conclusion

Patients with Pure mania exhibited distinct clinical and psychosocial features compared with patients with the Mania with mild depression. Further studies are warranted to investigate the underlying mechanisms for diverse presentations in subgroups of BDs.

Limitations

These results apply to a relatively short outcome period, and the sample size is relatively small.

目的：一部分双相情感障碍（BD）患者仅表现为单极躁狂（UM）。我们对诊断为单相躁狂症的患者进行了一项随访研究，并将他们作为一组进行比较，如果他们有轻度抑郁发作，与没有轻度抑郁发作的患者进行比较。方法：对248例患者进行15年的前瞻性随访。在15年的随访研究中，纯躁狂被定义为没有轻度抑郁发作的患者（203），躁狂伴轻度抑郁被定义为经历轻度抑郁发作的患者（45）。然后，我们比较了纯躁狂（PM）和躁狂伴轻度抑郁（MMD）的临床特征。结果：与躁狂症合并轻度抑郁组相比，单纯躁狂症组精神病性症状较多，自杀行为较少，晨型比例较高，睡眠质量较好，外向性较高，神经质程度较低，避害人格特征较少。在两组之间观察到明显不同的终生共病模式。结论：单纯躁狂症患者与伴轻度抑郁的躁狂症患者相比，表现出明显的临床和社会心理特征。有必要进一步研究bd亚群中不同表现的潜在机制。局限性：这些结果适用于相对较短的结果期，样本量相对较小。

{"title":"Unipolar mania over the course of a 15-year follow-up study","authors":"Hua-Meng Shi , De-Gua Jiang","doi":"10.1016/j.psychres.2024.116348","DOIUrl":"10.1016/j.psychres.2024.116348","url":null,"abstract":"<div><h3>Objective</h3><div>A proportion of patients with bipolar disorder (BD) manifests with only Unipolar mania (UM). We conducted a follow-up study of patients diagnosed with Unipolar mania and compared them as a group if they had a mild depressive episode with those who did not.</div></div><div><h3>Method</h3><div>248 subjects were prospectively followed-up to 15 years. During the 15-year follow-up study, Pure mania was defined as patients who did not experience mild depressive episodes(203) and Mania with mild depression was defined as patients who did experience mild depressive episodes(45). Then, we compare characterization of clinical features between Pure mania (PM) and Mania with mild depression (MMD).</div></div><div><h3>Results</h3><div>Compared with the Mania with mild depression group, the Pure mania group had more psychotic symptoms, fewer suicidal behaviors, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Substantially different lifetime comorbidity patterns were observed between the two groups.</div></div><div><h3>Conclusion</h3><div>Patients with Pure mania exhibited distinct clinical and psychosocial features compared with patients with the Mania with mild depression. Further studies are warranted to investigate the underlying mechanisms for diverse presentations in subgroups of BDs.</div></div><div><h3>Limitations</h3><div>These results apply to a relatively short outcome period, and the sample size is relatively small.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116348"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Tribute to Timothy J. Crow: 1938–2024 向蒂莫西·j·克劳致敬：1938-2024。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-02-01 DOI: 10.1016/j.psychres.2024.116300

Lynn E. DeLisi

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Psychiatry Research

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀