Psychiatry Research最新文献

英文中文

Brain white matter structural connectivity of trauma and trauma-related dissociation disorders and symptoms

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-31 DOI: 10.1016/j.psychres.2025.116383

Lora I. Dimitrova , Sima Chalavi , Eline M. Vissia , Gareth J. Barker , David L. Perez , Dick J. Veltman , Ibai Diez , Antje A.T.S. Reinders

Background

Experiencing repeated childhood traumatisation impacts brain structure and function in individuals with dissociative identity disorder (DID) and post-traumatic stress disorder (PTSD). Quantitative grey matter neuroimaging research has shown aberrant volumes in traumatised individuals, however studies examining white matter are sparse, particularly for DID. The present study aims to examine white matter alterations of people with trauma-related disorders.

Methods

Sixty-five female participants were included in this study: 33 diagnosed with a trauma-related disorder, namely 17 with DID and 16 with PTSD, and 32 healthy control (HC) participants. All participants underwent diffusion tensor imaging (DTI) and completed dissociation and traumatisation self-report measures. White matter integrity was characterised using voxel-based analysis (VBA), with network lesion mapping used to identify the implicated grey matter end points of the VBA findings.

Results

Between-group VBA comparisons showed reduced fractional anisotropy (FA) for participants with DID compared to HCs in bilateral pallidum (implicating striatal projections to pre/post central gyri), midbrain, and pontocerebellar white matter. Compared to those with PTSD, DID subjects showed increased FA in the right internal capsule and right temporal areas (predominantly implicating the inferior longitudinal fasciculus). Across DID and PTSD subjects, FA values within the aforementioned findings negatively correlated with depersonalisation, psychoform and somatoform dissociation, and/or traumatisation scores.

Conclusions

Our DTI findings indicate markedly differential white matter integrity in DID compared to PTSD and HCs. This provides valuable mechanistic insights regarding a role for aberrant white matter structural integrity in traumatised female individuals with DID.

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引用次数: 0

Stress sensitivity in women with a history of recurrent versus first-episode major depression

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-30 DOI: 10.1016/j.psychres.2025.116382

Amber K.X. Gan, Brandon E. Gibb

Approximately 50 % of people who recover from an initial episode of major depressive disorder (MDD) experience a recurrence, and the risk for recurrence increases with each additional episode. Consistent with the stress sensitization model, there is evidence that whereas initial MDD onsets are often preceded by major negative life events, recurrences are often triggered by more minor events. However, it is unclear whether this is due to increased frequency of minor life events, increased reactivity to these events, or both. The current study examined these questions in a community sample of 227 adult women with a history of recurrent MDD (rMDD, n = 77), first-episode MDD (fMDD, n = 38), or no history of MDD (n = 112). Women were assessed at baseline and every six months for two years (5 assessments total). Throughout the follow-up, major and minor life events were assessed using contextual threat interviews and depressive symptoms were assessed using a self-report questionnaire. Regarding event frequency, minor events were more common than major events, and the rMDD group experienced more negative events overall (both major and minor) than the never depressed group but not the fMDD group. Regarding stress reactivity, results of linear mixed modeling revealed that whereas all three groups exhibited similar increases in depressive symptoms following major events, only women in the rMDD group experienced significant increases in depressive symptoms following minor events. These findings show that not only are women with rMDD living in more stressful contexts, but they are also more reactive to minor stressors, increasing risk for future depression.

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引用次数: 0

Effects of objective and perceived weight on suicidal ideation among adolescents: Findings from the 2015–2021 national Youth Risk Behavior Survey

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-29 DOI: 10.1016/j.psychres.2025.116380

Philip Baiden , Catalina Cañizares , Catherine A. LaBrenz , Christina M. Sellers , Yong Li , Raymond M. Glikpo , Kofi Sarkodie

This study examined the association between perceived weight, actual weight, and suicidal ideation among adolescents. Data for this study were obtained from a nationally representative sample from the Youth Behavior Risk Survey (YRBS) between 2015 and 2021. A total of n = 61,298 adolescents ages 12 to 18 were included in the final analytic sample. A series of logistic regressions was conducted to examine perceived weight, BMI, and suicidal ideation, while adjusting for other demographic and control variables. Approximately one in five adolescents reported suicidal ideation. In the multivariable analyses, adolescents who perceived themselves as overweight and had BMI ≥ 85th percentile had 1.48 times higher odds of reporting suicidal ideation (95 % CI=1.35–1.62) and adolescents who perceived themselves as overweight but had BMI <85th percentile had 1.47 times higher odds of experiencing suicidal ideation than their peers who did not perceive themselves as overweight and had BMI <85th percentile. The findings from this study suggest that both perceived and actual BMI may be associated with suicidal ideation among adolescents. Future research could examine differences in perceived and actual BMI and identify potential interventions to proactively address mental health issues that may stem from stigma related to being overweight or obese.

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引用次数: 0

Neural correlates of executive function and attention in children with ADHD: An ALE meta-analysis of task-based functional connectivity studies

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-29 DOI: 10.1016/j.psychres.2024.116338

Meng Wang , Jing Yu , Hyun-Duck Kim , Angelita Bautista Cruz

We conducted a comprehensive meta-analysis of task-based functional MRI studies on executive function and attention in children with attention deficit hyperactivity disorder (ADHD). We searched for studies published before March 20, 2023, in PubMed, Cochrane Library, Web of Science, EBSCO, Embase, and Scopus. The ALE (activation likelihood estimation) method was used to detect differences in brain activation between children with ADHD and comparison children. Fifty-seven (57) studies were included, with 2,231 participants (1,062 children with ADHD). Based on the omnibus meta-analysis findings, significant hypoactivation in children with ADHD relative to comparisons was observed in the frontoparietal network, putamen, insula, cingulate gyrus, and middle temporal gyrus, while ADHD-related hyperactivation was present in the occipital lobe, declive, middle frontal gyrus, and parahippocampal gyrus. This study highlights the critical involvement of the parietal lobe. Results also revealed abnormalities in the frontal lobe and brainstem, suggesting unintegrated primitive reflexes. For stimulant-naive children with ADHD, significant hypoactivation in the right cerebrum was observed compared to controls. Finally, dysfunctional connectivity between the frontoparietal network and the striatum may lead to inefficient working memory, while the cerebellum plays a crucial role in inhibitory control and attention tasks. These findings provide important insights into the pathology of ADHD.

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引用次数: 0

Potential benefits of ketone therapy as a novel immunometabolic treatment for schizophrenia

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-29 DOI: 10.1016/j.psychres.2025.116379

Karin Huizer , Shubham Soni , Mya A. Schmidt , Nuray Çakici , Lieuwe de Haan , Jason R.B. Dyck , Nico J.M. van Beveren

Therapeutic ketosis could target the potential bio-energetic pathophysiology of schizophrenia. Ideally, novel treatments also target the possible inflammatory aspects of schizophrenia.

Adult mice (n = 30) were treated with ketone ester (KE) or vehicle for 3 days, next LPS- or PBS-injected. Brains were collected the next day. KE significantly attenuated the increased transcription of the pro-inflammatory cytokines Tnf-a, Il-6 and Il-1b, without affecting anti-inflammatory/immunomodulatory cytokines (Il-4, Il-10, Il-11) in whole brain.

KE potently dampened neuro-inflammation in this acute inflammation mouse model. Ketone therapy could simultaneously target two possible pathophysiological pathways in schizophrenia. We encourage more research into the immunometabolic potential of therapeutic ketosis in schizophrenia.

引用次数: 0

Suicide of a patient shortly after psilocybin-assisted psychedelic therapy: A case report

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-29 DOI: 10.1016/j.psychres.2025.116381

Felix Müller , Thomas Sauer , Corina Hänny , Markus Mühlhauser , Undine E. Lang

引用次数: 0

Distribution and correlates of long-acting injectable antipsychotic use among community mental health center patients

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-26 DOI: 10.1016/j.psychres.2025.116378

Matthew C. Lohman , Victoria Scott , Mansi Verma , Paige Jones , Eve Fields

Although long-acting injectable antipsychotics (LAIs) are an important pharmaceutical option in the management of schizophrenia and related disorders, little is known about patient characteristics related to LAI use in real-world outpatient settings. We analyzed electronic medical records from 41,401 patients who received psychiatric services from one of 16 regional mental health centers operated by the South Carolina Department of Mental Health in 2022. We compared the use of first- and second-generation LAIs and oral antipsychotics by sociodemographic (age, gender, race/ethnicity, zip code, payment source) and clinical characteristics (psychiatric diagnoses, service use). We used logistic regression models to estimate associations between patient characteristics and the likelihood of using LAIs. In total, 7,029 (17.0 %) patients used LAIs in 2022, including 5,901 with schizophrenia or another psychotic disorder. Compared to White patients, Black (Odds Ratio (OR): 2.19, 95 % Confidence Interval (CI): 1.96 – 2.44) and Asian (OR: 3.39, 95 % CI: 1.54 – 7.43) patients were significantly more likely to use LAIs, controlling for other patient demographic and clinical characteristics. LAI users were also more likely to be male (OR: 1.83, 95 % CI: 1.64, 2.03), to live in suburban areas (OR: 1.25, 95 % CI: 1.10, 1.42), and to use Medicaid (OR: 1.55, 95 % CI: 1.34, 1.79). Similar differences were not found for oral antipsychotics. Results suggest that LAI use differs substantially by patient characteristics independent of psychiatric diagnoses. Identifying and understanding reasons for differences in LAI use is important to promote equitable access to and use of LAIs across racial, geographic, and other sociodemographic groups.

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引用次数: 0

Comparison of attention and brain functional connectivity between patient groups with schizophrenia and attention deficit hyperactivity disorder

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-26 DOI: 10.1016/j.psychres.2025.116376

Hyunchan Hwang, Sun Mi Kim, Hee Jin Kim, Doug Hyun Han

Schizophrenia and attention deficit hyperactivity disorder (ADHD) have many contradicting features, but both these disorders share inattention as a core symptom. This study explored how the characteristics of inattention differ between the two disorders. 20 patients with schizophrenia, 20 patients with adult ADHD and 20 healthy controls participated in this study. Comprehensive attention test, Korean Wechsler adult intelligence scale-IV and resting-state functional magnetic resonance imaging (fMRI) were collected, among other things. The schizophrenia and ADHD groups showed low and high levels of functional connectivity in the default mode network (DMN), respectively. Functional connectivity level within the DMN was also positively correlated with processing speed index in the schizophrenia group and positively correlated with the number of divided-attention commission errors in the ADHD group. These results show that schizophrenia and adult ADHD have similarities in the characteristics of attention deficit, in that both may arise from dysregulation within the DMN. However, the differences in the levels of functional connectivity in the DMN between these groups affect how inattention manifests in each group.

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引用次数: 0

Low-dose ketamine improved brain network integrity among patients with treatment-resistant depression and suicidal ideation

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-26 DOI: 10.1016/j.psychres.2025.116377

Tung-Ping Su , Li-Kai Cheng , Pei-Chi Tu , Li-Fen Chen , Wei-Chen Lin , Cheng-Ta Li , Ya-Mei Bai , Shih-Jen Tsai , Mu-Hong Chen

Background

Ketamine is a dissociative drug used for the treatment of depression. However, the neurofunctional mechanism underlying the antidepressant effect of ketamine remains unknown. According to previous research, low-dose ketamine affects large-scale brain networks, including default-mode and salient networks.

Methods

A total of 43 patients with treatment-resistant depression (TRD) and suicidal ideation (SI) were randomly assigned to receive a single infusion of either 0.5 mg/kg ketamine or 0.045 mg/kg midazolam. Depressive and suicidal symptoms were evaluated using the 17-item Hamilton Depression Rating Scale and the Columbia–Suicide Severity Rating Scale: Ideation Severity Subscale. Resting-state functional magnetic resonance imaging was performed at baseline and on day 3 after infusion. Graph theoretic metrics such as degree centrality and clustering coefficient were examined.

Results

Relative to midazolam use, low-dose ketamine infusion reduced depressive (p = 0.001) and suicidal (p = 0.025) symptoms and improved the brain network integrity, including increased degree centrality and clustering coefficient in the angular gyrus and increased degree centrality in the right thalamus.

Discussion

Neurofunctional changes in the thalamus and default-mode network (angular gyrus) may be associated with the antidepressant effect of ketamine on patients with TRD and SI.

Clinical trials registration

UMIN Clinical Trials Registry (UMIN-CTR): Registration number: UMIN000033916.

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引用次数: 0

Understanding the incidence and recurrence of depression and associated risk factors in 9 years of follow-up: Results from a population-based sample

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research

Pub Date : 2025-01-24 DOI: 10.1016/j.psychres.2025.116375

Beatriz Olaya , Carlota de Miquel , Lea Francia , Cristina Rodríguez-Prada , Blanca Dolz del Castellar , José Luis Ayuso-Mateos , Josep Maria Haro , Joan Domènech-Abella

Introduction

This paper aims to analyse depression incidence and recurrence rates in a Spanish adult cohort, while also investigating associated risk factors based on depression status at baseline.

Methods

Longitudinal, prospective study data of the Edad con Salud cohort was used, which comprises a sample representative of the non-institutionalized adult populace at the national level with a final sample size of 2655 Spanish adults. Competing risk regression models were estimated to determine the main risk factors for incident and recurrent depression.

Results

The study found depression incidence at 6.11 per 1,000 person years, with recurrence rates up to 47.8 and 21.3 per 1,000 person years in those with depression at baseline and only history of depression, respectively, with higher rates found among women. Sociodemographic factors were found to primarily predict incident depression, while health and mental health indicators were significant predictors for recurrent depression.

Conclusions

Our results confirm the augmented risk of experiencing a new episode among individuals with proximal depression, where different risk factors seemed to play a role depending on episode type and depression proximity. These findings provide valuable insights for developing preventive strategies for depression in both the general population and those at risk.

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