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A multi-cohort assessment of the polygenic prediction in ADHD treatment response ADHD治疗反应多基因预测的多队列评估。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.psychres.2026.116988
Diego L. Rovaris , Eugenio H. Grevet , André Høberg , Pâmela F. da Cunha , Natalia Llonga , Pau Carabí-Gassol , Eduarda P. Oliveira , Cibele E. Bandeira , Maria Eduarda A. Tavares , María Soler Artigas , Josep Antoni Ramos-Quiroga , Christian Fadeuilhe , Montse Corrales , Vanesa Richarte , Astri J. Lundervold , Anne Halmøy , Eduardo S. Vitola , Luis A. Rohde , Marta Ribasés , Jan Haavik , Bruna S. da Silva
Pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD) are efficacious and safe; however, substantial interindividual variability in treatment response persists, with many patients experiencing suboptimal outcomes or early discontinuation. Although genetic factors have been proposed as contributors to this variability, clinically actionable predictors remain elusive. Here, we present the first meta-analysis evaluating whether polygenic liability for ADHD and related psychiatric and behavioral-cognitive phenotypes is associated with clinically meaningful response to methylphenidate in 1000 ADHD cases from Norway, Brazil, and Spain assessed in real-world settings. Polygenic scores (PGS) for ADHD, autism, bipolar disorder, educational attainment, major depressive disorder, neuroticism, and schizophrenia were calculated separately for each cohort. Treatment response was assessed using evaluations of global clinical improvement and harmonized by categorizing individuals as responders or non-responders. Cohort-specific associations were combined using fixed-effects meta-analysis. No PGS showed a significant association with treatment response. Effect sizes were small, consistent across cohorts, and characterized by minimal between-study heterogeneity. Sensitivity analyses incorporating clinical and treatment-related covariates yielded convergent results. As the first meta-analytic evaluation of polygenic predictors evaluating clinically meaningful ADHD stimulant response, these findings delineate the current limits of PGS in pharmacogenomic applications. Rather than supporting immediate clinical utility, our results highlight key methodological and conceptual constraints, including limited sample sizes, heterogeneous outcome definitions, and the indirect nature of susceptibility-based PGS for predicting treatment response. By mapping these boundaries, this study provides a framework to recalibrate research priorities and guide the next generation of ADHD pharmacogenomic studies toward larger, harmonized, and more informative definitions of treatment response.
注意缺陷/多动障碍(ADHD)的药物治疗是有效和安全的;然而,治疗反应的个体间差异仍然存在,许多患者经历了次优结果或早期停药。虽然遗传因素被认为是造成这种变异的因素,但临床可操作的预测因素仍然难以捉摸。在这里,我们提出了第一项荟萃分析,评估了来自挪威、巴西和西班牙的1000例ADHD病例的多基因倾向以及相关的精神和行为认知表型是否与哌甲酯的临床有意义的反应有关。对每个队列分别计算ADHD、自闭症、双相情感障碍、教育程度、重度抑郁症、神经质和精神分裂症的多基因评分(PGS)。使用全球临床改善评估来评估治疗反应,并通过将个体分类为反应者或无反应者来协调。使用固定效应荟萃分析合并特定队列的关联。没有PGS显示出与治疗反应的显著关联。效应量很小,在整个队列中一致,并且研究之间的异质性最小。纳入临床和治疗相关协变量的敏感性分析得出了趋同的结果。作为首个对多基因预测因子进行meta分析评估的研究,这些发现揭示了PGS在药物基因组学应用中的局限性。我们的研究结果强调了关键的方法和概念上的限制,包括有限的样本量、异构的结果定义,以及基于易感性的PGS预测治疗反应的间接性质,而不是支持立即的临床应用。通过绘制这些边界,本研究提供了一个框架来重新校准研究重点,并指导下一代ADHD药物基因组学研究朝着更大、更协调、更有信息的治疗反应定义方向发展。
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引用次数: 0
From noise to signal: Interpreting heterogeneity in ADHD-related non-suicidal self-injury 从噪音到信号:解释adhd相关非自杀性自伤的异质性。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1016/j.psychres.2026.117001
Herul Wahyudin , Maria Oktasari , Ida Dwi Lestari
Meta-analytic evidence indicates that non-suicidal self-injury (NSSI) is substantially more prevalent among individuals with attention-deficit/hyperactivity disorder (ADHD), yet estimates are accompanied by extreme between-study heterogeneity and preliminary sex-stratified differences. In this Letter to the Editor, we argue that such heterogeneity should be interpreted not only as a methodological limitation but also as a clinically meaningful signal of multiple, context-dependent pathway configurations linking ADHD and NSSI. We propose a pathway-oriented framing in which ADHD related NSSI vulnerability may cluster around impulsivity/emotion dysregulation, internalizing burden, and context-sensitive factors that shape detection and help seeking. We further caution that sex-related estimates may be influenced by gender differences in symptom expression, diagnostic timing, and measurement practices, and therefore require explicitly gender-sensitive designs. Finally, we outline how this interpretation can strengthen translation by supporting person-centered, context sensitive screening—pairing routine NSSI assessment with brief internalizing probes—without extending the scope of the original meta-analysis.
荟萃分析证据表明,非自杀性自伤(NSSI)在注意缺陷/多动障碍(ADHD)患者中更为普遍,但估计结果存在极端的研究间异质性和初步的性别分层差异。在这封致编辑的信中,我们认为这种异质性不仅应该被解释为方法上的限制,而且应该被解释为连接ADHD和自伤的多种环境依赖通路配置的临床有意义的信号。我们提出了一个途径导向的框架,其中ADHD相关的自伤脆弱性可能集中在冲动性/情绪失调、内化负担和影响检测和寻求帮助的情境敏感因素周围。我们进一步提醒,性别相关的估计可能受到症状表达、诊断时间和测量方法的性别差异的影响,因此需要明确的性别敏感设计。最后,我们概述了这种解释如何通过支持以人为中心的、上下文敏感的筛选——将常规自伤评估与简短的内化探针配对——而不扩展原始元分析的范围,从而加强翻译。
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引用次数: 0
Social networks and symptomatology in recently hospitalized individuals with schizophrenia-spectrum disorders: A six-month longitudinal study 最近住院的精神分裂症谱系障碍患者的社会网络和症状学:一项为期六个月的纵向研究
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.psychres.2026.116960
Gabriella V. Schock , Andrew R. Kittleson , Annalise S. Halverson , Jinyuan Liu , Julia M. Sheffield
Individuals with psychosis have reduced social networks; however, little is known about whether social networks change over time, particularly after an acute episode requiring hospitalization. Furthermore, longitudinal associations between social network engagement, symptom severity, and the impact of illness duration remains unclear. Using linear mixed models controlling for age and sex, we analyzed self-reported social network engagement, positive and negative symptom severity, and self-reported paranoia in individuals with a schizophrenia-spectrum disorder (SSD; N = 68) during six months following psychiatric hospitalization and compared them with non-clinical participants (NC; N = 70). SSD participants reported significantly lower social network scores than NC participants at every time point (b = –5.77), and significantly greater disruption in friendship than family ties (b = – 2.00). Social networks remained stable over time in both groups (b = –0.01), regardless of illness stage in the SSD group (b = 8.08). Notably, lower social engagement with family at baseline predicted greater increases in paranoia over time (b = –1.01). Conversely, more severe paranoia at baseline predicted greater reductions in friend networks over time (b = –0.03). Finally, social network related to negative symptom severity at baseline (b = –0.42) and longitudinally (b = –0.18). These findings suggest that clinical severity may influence the social network disruptions commonly found in psychotic disorders, especially during vulnerable periods of recovery following a psychotic exacerbation. Ultimately, this highlights the need for tailored post-discharge interventions that address social network deficits, particularly within families and in the context of severe paranoia.
精神病患者的社交网络较少;然而,人们对社交网络是否会随着时间的推移而改变知之甚少,尤其是在需要住院治疗的急性发作之后。此外,社会网络参与、症状严重程度和疾病持续时间的影响之间的纵向关联尚不清楚。使用控制年龄和性别的线性混合模型,我们分析了精神分裂症谱系障碍患者(SSD; N = 68)在精神病住院后6个月内自我报告的社交网络参与、阳性和阴性症状严重程度以及自我报告的偏执,并将其与非临床参与者(NC; N = 70)进行了比较。SSD参与者在每个时间点的社交网络得分都明显低于NC参与者(b = - 5.77),友谊的破坏程度明显高于家庭关系(b = - 2.00)。两组的社交网络随着时间的推移保持稳定(b = -0.01),与SSD组的疾病阶段无关(b = 8.08)。值得注意的是,基线时较低的家庭社交参与度预示着随着时间的推移偏执狂会增加(b = -1.01)。相反,在基线时,更严重的偏执预示着随着时间的推移,朋友网络的减少幅度更大(b = -0.03)。最后,社交网络在基线(b = -0.42)和纵向(b = -0.18)上与负性症状严重程度相关。这些发现表明,临床严重程度可能会影响精神疾病中常见的社会网络中断,特别是在精神病加重后的脆弱恢复期。最终,这突出了需要量身定制的出院后干预措施,以解决社会网络缺陷,特别是在家庭内部和严重偏执的情况下。
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引用次数: 0
Transdiagnostic investigation of white matter integrity and cortical thickness in cognitive subgroups within the schizophrenia-bipolar spectrum 精神分裂症-双相谱系认知亚群白质完整性和皮质厚度的跨诊断研究
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.psychres.2026.116964
Burcu Verim , Cemal Demirlek , Nabi Zorlu , Burak Erdeniz , Ozge Akgul , Deniz Ceylan , Koksal Alptekin , Aysegul Ozerdem , Berna Binnur Akdede , Emre Bora

Background

Cognitive deficits are cardinal features of schizophrenia-spectrum disorders (SSD) and bipolar disorder (BD). However, their heterogeneous and overlapping characteristics require a dimensional approach to better understand the neurobiological basis of cognition in the psychosis spectrum. To date, only a few studies have examined the neuroanatomical features of cognitive subgroups in transdiagnostic samples, and white matter microstructural characteristics of these subgroups have not been elucidated. This study aimed to investigate white matter and cortical thickness alterations in cognitive subgroups in the schizophrenia-bipolar spectrum.

Methods

Globally Impaired (n = 31) and Near-Normal (n = 28) cognitive subgroups, comprising individuals diagnosed with schizophrenia (SZ), schizoaffective disorder (SAD) or BD, and healthy controls (HCs, n = 29), underwent 3T T1-weighted structural magnetic resonance imaging and diffusion tensor imaging scanning. Fractional anisotropy and cortical thickness measures were compared between the cognitive subgroups and healthy controls.

Results

Abnormalities in white matter microstructure were only observed in patients with global cognitive impairment compared to HCs. The Near-Normal subgroup did not differ from HCs in white matter integrity. A bilateral reduction in cortical thickness was observed in both the Globally Impaired and Near-Normal subgroups when compared to HCs. Cortical thickness measures did not differentiate between the cognitive subgroups.

Conclusions

While reductions in cortical thickness in frontal and temporal regions appear to be a common feature of SZ and BD, abnormalities in white matter microstructure are associated with global cognitive impairment in the schizophrenia-bipolar spectrum. These original findings may be important in identifying more biologically valid clinical syndromes within the schizophrenia-bipolar spectrum.
认知缺陷是精神分裂症谱系障碍(SSD)和双相情感障碍(BD)的主要特征。然而,它们的异质性和重叠特征需要一个维度的方法来更好地理解精神病谱系中认知的神经生物学基础。迄今为止,只有少数研究检查了跨诊断样本中认知亚群的神经解剖学特征,并且这些亚群的白质微观结构特征尚未阐明。本研究旨在研究精神分裂症-双相情感障碍认知亚组中白质和皮质厚度的变化。方法认知功能全面受损(n = 31)和接近正常(n = 28)亚组,包括被诊断为精神分裂症(SZ)、分裂情感障碍(SAD)或BD的个体,以及健康对照(hc, n = 29),接受3tt1加权结构磁共振成像和弥散张量成像扫描。在认知亚组和健康对照组之间比较分数各向异性和皮质厚度测量。结果与hc相比,白质微结构异常仅在整体认知障碍患者中观察到。近正常亚组与hc在白质完整性方面没有差异。与hcc相比,在整体受损和接近正常亚组中均观察到双侧皮质厚度减少。皮质厚度测量不能区分认知亚组。结论:额叶和颞叶皮质厚度的减少似乎是SZ和BD的共同特征,而白质微观结构的异常与精神分裂症-双相障碍患者的整体认知障碍有关。这些最初的发现可能对识别精神分裂症-双相谱系中更多生物学上有效的临床综合征很重要。
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引用次数: 0
Prolonged grief and psychological distress among the public amidst the ongoing hostage crisis following the october 7 attack 在10月7日的袭击事件后,持续的人质危机给公众带来了长期的悲伤和心理困扰。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.psychres.2026.116978
Yoav Groweiss , Carmel Blank , Hili Kohavi , Doron Amsalem , Yuval Neria , Yossi Levi-Belz

Background

The October 7, 2023, terrorist attack in Israel led to over 1,200 civilian deaths and the abduction of 251 individuals to Gaza. While prior studies have documented the psychological toll on directly affected populations, the broader emotional impact of the ongoing hostage crisis on the general public remains unclear. This study explored how public concern for the hostages relates to psychological distress and functional impairment, focusing on prolonged grief–like responses in the context of unresolved national uncertainty.

Methods

A nationally representative sample of 515 Israeli adults completed self-report questionnaires at two time points: August 2023 (pre-attack) and May 2025. Measures included anxiety, depression, PTSD symptoms, cumulative stress, emotional burnout, and daily functioning. Concern for the hostages was rated on a 4-point scale. Symptoms associated with Prolonged Grief Disorder (PGD) were measured using an adapted PG-13 scale. Multivariate analyses controlled for baseline distress and trauma exposure.

Results

Higher concern levels were significantly associated with elevated distress across all symptom domains. Approximately half of the participants (48.7%) reported elevated levels of PGD-like symptoms in relation to the hostage situation, exhibiting significantly higher psychological symptoms and lower functional well-being, including poorer sleep, reduced concentration, and diminished optimism and hope.

Conclusions

Findings indicate that the prolonged hostage crisis constitutes a collective psychological burden marked by ambiguous loss and unresolved national trauma. This form of distress affects even those without direct exposure. Mental health efforts may therefore benefit from addressing distress related not only to direct trauma and bereavement, but also to prolonged uncertainty and symbolic loss.
背景:2023年10月7日在以色列发生的恐怖袭击导致1 200多名平民死亡,251人被绑架到加沙。虽然先前的研究记录了直接受影响人群的心理损失,但持续的人质危机对公众的更广泛的情感影响仍不清楚。本研究探讨了公众对人质的关注与心理困扰和功能障碍之间的关系,重点关注在未解决的国家不确定性背景下的长期悲伤反应。方法:在2023年8月(袭击前)和2025年5月两个时间点完成了515名以色列成年人的全国代表性样本自我报告问卷。测量包括焦虑、抑郁、创伤后应激障碍症状、累积压力、情绪倦怠和日常功能。对人质的关心程度分为4分。延长悲伤障碍(PGD)的相关症状采用改良的PG-13量表进行测量。多变量分析控制了基线窘迫和创伤暴露。结果:在所有症状领域中,较高的关注水平与升高的痛苦显著相关。大约一半的参与者(48.7%)报告说,与人质情况有关的pgd样症状水平升高,表现出明显较高的心理症状和较低的功能健康,包括睡眠较差、注意力不集中、乐观和希望减弱。结论:研究结果表明,长期的人质危机构成了一种集体心理负担,其特征是模糊的损失和未解决的民族创伤。这种形式的痛苦甚至影响到那些没有直接接触的人。因此,解决不仅与直接创伤和丧亲之痛有关的痛苦,而且与长期的不确定性和象征性损失有关的痛苦,可能有利于心理健康工作。
{"title":"Prolonged grief and psychological distress among the public amidst the ongoing hostage crisis following the october 7 attack","authors":"Yoav Groweiss ,&nbsp;Carmel Blank ,&nbsp;Hili Kohavi ,&nbsp;Doron Amsalem ,&nbsp;Yuval Neria ,&nbsp;Yossi Levi-Belz","doi":"10.1016/j.psychres.2026.116978","DOIUrl":"10.1016/j.psychres.2026.116978","url":null,"abstract":"<div><h3>Background</h3><div>The October 7, 2023, terrorist attack in Israel led to over 1,200 civilian deaths and the abduction of 251 individuals to Gaza. While prior studies have documented the psychological toll on directly affected populations, the broader emotional impact of the ongoing hostage crisis on the general public remains unclear. This study explored how public concern for the hostages relates to psychological distress and functional impairment, focusing on prolonged grief–like responses in the context of unresolved national uncertainty.</div></div><div><h3>Methods</h3><div>A nationally representative sample of 515 Israeli adults completed self-report questionnaires at two time points: August 2023 (pre-attack) and May 2025. Measures included anxiety, depression, PTSD symptoms, cumulative stress, emotional burnout, and daily functioning. Concern for the hostages was rated on a 4-point scale. Symptoms associated with Prolonged Grief Disorder (PGD) were measured using an adapted PG-13 scale. Multivariate analyses controlled for baseline distress and trauma exposure.</div></div><div><h3>Results</h3><div>Higher concern levels were significantly associated with elevated distress across all symptom domains. Approximately half of the participants (48.7%) reported elevated levels of PGD-like symptoms in relation to the hostage situation, exhibiting significantly higher psychological symptoms and lower functional well-being, including poorer sleep, reduced concentration, and diminished optimism and hope.</div></div><div><h3>Conclusions</h3><div>Findings indicate that the prolonged hostage crisis constitutes a collective psychological burden marked by ambiguous loss and unresolved national trauma. This form of distress affects even those without direct exposure. Mental health efforts may therefore benefit from addressing distress related not only to direct trauma and bereavement, but also to prolonged uncertainty and symbolic loss.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116978"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “Prevalence of subthreshold depression among older adults with mild cognitive impairment: a systematic review and meta-analysis” 对“轻度认知障碍老年人阈下抑郁症的患病率:一项系统回顾和荟萃分析”的评论。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.psychres.2026.116984
Hailun Xia , Yuanyi Yang
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引用次数: 0
Letter to the Editor regarding “Efficacy of esketamine after cesarean section for women with symptoms of prenatal depression: A randomized controlled trial” 致编辑的信关于“剖宫产后艾氯胺酮对有产前抑郁症状的妇女的疗效:一项随机对照试验”
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-01-24 DOI: 10.1016/j.psychres.2026.116976
Yuanyi Yang , Hailun Xia
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引用次数: 0
Data analysis of mortality patterns in psychiatry: A retrospective study of sociodemographic and service-related risk factors 精神病学死亡率模式的数据分析:社会人口统计学和服务相关危险因素的回顾性研究。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-04-01 Epub Date: 2026-02-02 DOI: 10.1016/j.psychres.2026.116993
Esther Bloemhof-Bris , Masha Dubrovsky , Shai Fogelhut , Yerus Falaka , Sharon Nir Genesh , Assaf Shelef , Zohar Barnett-Itzhaki
Individuals with severe mental illness (SMI) experience markedly reduced life expectancy, yet evidence on the sociodemographic and service-related factors contributing to premature mortality within psychiatric populations remains limited, particularly in Israel. Here we analyzed electronic health records from 4253 patients who underwent a total of 19,902 hospitalizations at Lev Hasharon Mental Health Center in 2020–2024. Among these patients, 346 were confirmed deceased. Sociodemographic and clinical variables were extracted, including sex, marital status, parenthood, immigration characteristics, and hospitalization history. Statistical analyses included descriptive statistics, correlation tests, and inferential statistics. The mean age at death was 59.97 ± 18.29 years, significantly lower than national life expectancy for both men and women (p < 0.001). Male patients died younger than females (58.2 vs 63.1 years), reflecting an average life-expectancy reduction of 22.5 years in men and 21.5 years in women. Earlier mortality was associated with male gender, single marital status, absence of children, and a higher number of hospitalizations (Spearman R = –0.223, p < 0.001). Life expectancy varied significantly by region, with younger deaths observed among patients born in Israel, Ethiopia, and American countries.
In conclusion, psychiatric patients in Israel die approximately two decades earlier than the general population. Social and service-related characteristics, particularly male sex, social isolation, and repeated hospitalizations emerge as key predictors of premature death. These findings underscore the need for targeted, socially informed interventions to mitigate excess mortality in severe mental illness.
患有严重精神疾病(SMI)的个体预期寿命明显缩短,但关于导致精神病人群过早死亡的社会人口统计学和服务相关因素的证据仍然有限,特别是在以色列。在这里,我们分析了来自4253名患者的电子健康记录,这些患者在2020-2024年期间在Lev Hasharon心理健康中心接受了19,902次住院治疗。其中346人确认死亡。提取社会人口学和临床变量,包括性别、婚姻状况、父母身份、移民特征和住院史。统计分析包括描述性统计、相关检验和推论统计。平均死亡年龄为59.97±18.29岁,显著低于全国男性和女性的预期寿命(p < 0.001)。男性患者的死亡年龄小于女性(58.2岁vs 63.1岁),反映出男性平均预期寿命减少22.5岁,女性平均预期寿命减少21.5岁。早期死亡率与男性性别、单身婚姻状况、无子女和较高的住院次数有关(Spearman R = -0.223, p < 0.001)。预期寿命因地区而异,在以色列、埃塞俄比亚和美洲国家出生的患者中,死亡率较低。综上所述,以色列的精神病患者比一般人群早死大约20年。社会和服务相关特征,特别是男性、社会孤立和反复住院成为过早死亡的关键预测因素。这些发现强调需要有针对性的、社会知情的干预措施,以减轻严重精神疾病的过高死亡率。
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引用次数: 0
Breaking the spline: Why distributed lag non-linear models miss thresholds in environmental psychiatry. 打破样条:为什么分布滞后非线性模型错过了环境精神病学的阈值。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-03-17 DOI: 10.1016/j.psychres.2026.117104
Souichi Oka, Takuma Yamazaki, Yoshiyasu Takefuji

This critique evaluates Monti et al.'s investigation into associations between air pollution, apparent temperature, and schizophrenia severity. While their findings indicate significant short‑ and medium‑term effects of PM10 and thermal stress on PANSS scores, several methodological limitations warrant caution. Their study relies on residential exposure assignments, which may not capture individual mobility or indoor environments, potentially introducing substantial exposure misclassification. Despite appropriately modeling delayed and non-linear effects, the DLNM's reliance on predefined spline structures may oversimplify the complex, synergistic interactions among atmospheric variables. Seasonal discrepancies-such as the absence of PM10 effects in autumn-winter-may reflect unmodeled dependencies or limited pollutant data, particularly for PM2.5 and black carbon. To address these constraints, future research should incorporate flexible, data‑driven approaches, particularly those capable of uncovering latent structures within environmental mixtures. Unsupervised feature‑clustering methods can identify correlated pollutant groupings and reduce dimensional noise, while rank‑based correlation metrics provide robust assessment of non‑linear dependencies that are often obscured by parametric spline specifications. These non‑parametric techniques can complement DLNM by capturing multivariate synergies and interaction patterns that rigid basis structures may overlook. Overall, integrating such approaches is essential for advancing analytical capacity and improving risk assessment for vulnerable psychiatric populations.

这篇评论评价了Monti等人对空气污染、体表温度和精神分裂症严重程度之间关系的调查。虽然他们的研究结果表明PM10和热应力对PANSS评分有显著的短期和中期影响,但一些方法上的局限性值得谨慎。他们的研究依赖于住宅暴露分配,这可能没有捕捉到个人的流动性或室内环境,可能会导致大量的暴露错误分类。尽管适当地模拟延迟和非线性效应,DLNM对预定义样条结构的依赖可能会过度简化大气变量之间复杂的协同相互作用。季节差异——比如秋冬季没有PM10的影响——可能反映了未建模的依赖性或有限的污染物数据,特别是PM2.5和黑碳。为了解决这些限制,未来的研究应该采用灵活的、数据驱动的方法,特别是那些能够揭示环境混合物中潜在结构的方法。无监督特征聚类方法可以识别相关的污染物分组并降低维度噪声,而基于等级的相关度量提供了通常被参数样条规范模糊的非线性依赖关系的稳健评估。这些非参数技术可以通过捕获刚性基础结构可能忽略的多元协同作用和相互作用模式来补充DLNM。总的来说,整合这些方法对于提高分析能力和改善弱势精神病人群的风险评估至关重要。
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引用次数: 0
Prevalence and mental health correlates of non-suicidal self-injury in elementary school children. 小学生非自杀性自伤发生率及心理健康相关性研究
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-03-16 DOI: 10.1016/j.psychres.2026.117097
Shadi Hadj-Youssef, Alessia Civita, Elise Chartrand, Catherine Malboeuf-Hurtubise, Julia Fuoco, Tianna Loose, Isabelle Ouellet-Morin, Nancy Heath, Nathalie Maltais, Imke Baetens, Michel Spodenkiewicz, Sylvana Côté, Marie-Claude Geoffroy

Background: Non-suicidal self-injury (NSSI) is relatively common in adolescence and associated with mental health symptoms, yet the prevalence of NSSI and mental health correlates in childhood remain poorly understood.

Objective: Document the lifetime prevalence of NSSI in elementary-school children and concurrent associations with self- and teacher-reported mental health symptoms and peer problems.

Methods: Cross sectional analysis of 859 children (mean age=10.9 years; n = 419 males) from 33 elementary schools in Quebec, Canada who completed a self-report measure of NSSI (5-item Self-Mutilation subscale; Self Harm Inventory) and self- and teacher-report measures of concurrent mental health, including depressive symptoms (Children's Depression Inventory-Short-Form; self-reported only), emotional distress, withdrawal, impulsive/hyperactive/inattentive behaviors, disruptive behaviors, prosocial behaviors, and peer relationship difficulties (victimization) (Social Behavior Questionnaire). Mental health symptoms were transformed into z-scores.

Results: Lifetime prevalence of NSSI (any method, at least once) was 28.2 %, with no sex differences between males (26.7 %) and females (29.4 %) (p=.403), with scratching being the most frequently reported method (17.2 %). Children reporting NSSI had significantly poorer mental health across indicators examined in both self- and teacher reports, although associations were generally smaller for teacher-reported symptoms. To illustrate, for 1 standard deviation increase in self-reported symptom scores, odds of NSSI were 2.31 times higher for depressive symptoms (95 % CI 1.82-2.92), and 1.70 times higher for peer victimization (95 % CI 1.46-1.99). Associations were stronger among children endorsing multiple NSSI methods compared to those reporting only one.

Conclusion: NSSI (especially scratching) is present in late childhood and associated with worse mental health symptoms and peer problems.

背景:非自杀性自伤(NSSI)在青少年中相对常见,并与心理健康症状相关,但对儿童期自伤患病率和心理健康相关性的了解仍然很少。目的:探讨小学生自伤的终生发生率及其与自我和教师报告的心理健康症状和同伴问题的关系。方法:对来自加拿大魁北克省33所小学的859名儿童(平均年龄=10.9岁,n = 419名男性)进行横断面分析,这些儿童完成了自伤自我报告量表(5项自残子量表;自我伤害量表)和自我和教师报告的同期心理健康量表,包括抑郁症状(儿童抑郁量表-短表;(社会行为问卷)、情绪困扰、退缩、冲动/多动/注意力不集中行为、破坏性行为、亲社会行为和同伴关系困难(受害)。心理健康症状转化为z分数。结果:终生自伤发生率(任何方法,至少一次)为28.2%,男性(26.7%)和女性(29.4%)之间无性别差异(p=.403),搔抓是最常见的自伤方法(17.2%)。报告自伤的儿童在自我报告和教师报告的各项指标中,心理健康状况都明显较差,尽管教师报告的症状与自伤的关联通常较小。为了说明,自我报告症状评分每增加1个标准差,抑郁症状的自伤几率高2.31倍(95% CI 1.82-2.92),同伴伤害的几率高1.70倍(95% CI 1.46-1.99)。赞成多种自伤方法的儿童与只赞成一种自伤方法的儿童之间的关联更强。结论:自伤(尤其是抓挠)出现在儿童晚期,并与较差的心理健康症状和同伴问题相关。
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引用次数: 0
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Psychiatry Research
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