Pub Date : 2026-04-01Epub Date: 2026-01-17DOI: 10.1016/j.psychres.2026.116951
Daniel A. Vazquez-Matias, Erik F.J. de Vries, Cyprien G.J. Guerrin, Kavya Prasad, Janine Doorduin
This study aimed to investigate whether there are metabolic connectivity alterations in the brain of rats with a depressive-like phenotype, using positron emission tomography (PET) and graph theory methods. Male Wistar rats were exposed to 5 days of repeated social defeat (RSD) to induce a depressive-like phenotype, and brain connectivity was assessed with [18F]FDG-PET. Sucrose preference tests were conducted to assess anhedonia-like behaviour, a symptom of depression. The results showed that anhedonia-like behaviour was present one day after RSD and recovered after seven days. The analysis of large-scale brain networks revealed a reduction in connectivity in the default mode network of RSD-exposed animals one day after RSD, suggesting a link between reduced connectivity and the presence of anhedonia-like behaviour. Seven days after RSD, an increase in connectivity was observed in the salience network, which coincided with the recovery of sucrose preference. Modular analysis revealed different configurations of brain regions at one and seven days after RSD, with asymmetrical segregation of left and right hemisphere structures. These findings suggest that changes in brain connectivity may play a role in the development and recovery of anhedonia-like behaviour in rats exposed to RSD and may have implications for understanding depressive phenotypes.
{"title":"Metabolic brain connectivity analysis of a depressive-like phenotype in rats: a graph theory PET study","authors":"Daniel A. Vazquez-Matias, Erik F.J. de Vries, Cyprien G.J. Guerrin, Kavya Prasad, Janine Doorduin","doi":"10.1016/j.psychres.2026.116951","DOIUrl":"10.1016/j.psychres.2026.116951","url":null,"abstract":"<div><div>This study aimed to investigate whether there are metabolic connectivity alterations in the brain of rats with a depressive-like phenotype, using positron emission tomography (PET) and graph theory methods. Male Wistar rats were exposed to 5 days of repeated social defeat (RSD) to induce a depressive-like phenotype, and brain connectivity was assessed with [<sup>18</sup>F]FDG-PET. Sucrose preference tests were conducted to assess anhedonia-like behaviour, a symptom of depression. The results showed that anhedonia-like behaviour was present one day after RSD and recovered after seven days. The analysis of large-scale brain networks revealed a reduction in connectivity in the default mode network of RSD-exposed animals one day after RSD, suggesting a link between reduced connectivity and the presence of anhedonia-like behaviour. Seven days after RSD, an increase in connectivity was observed in the salience network, which coincided with the recovery of sucrose preference. Modular analysis revealed different configurations of brain regions at one and seven days after RSD, with asymmetrical segregation of left and right hemisphere structures. These findings suggest that changes in brain connectivity may play a role in the development and recovery of anhedonia-like behaviour in rats exposed to RSD and may have implications for understanding depressive phenotypes.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116951"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-22DOI: 10.1016/j.psychres.2026.116965
Leonor P. Gawron , Maria J. Portella , Esther Pousa
Objective
To study whether the insight described in psychosis also occurs in eating disorders (EDs), whether it differs between anorexia nervosa (AN) and bulimia nervosa (BN), and whether diagnosis-specific ED psychopathology mediates this relationship.
Methods
Cross-sectional baseline data from a prospective cohort of 103 day-hospital patients with AN or BN were analyzed. Standardized measures of insight, depressive symptoms, and ED psychopathology were administered. Exploratory factor analysis was conducted on depressive symptoms, followed by diagnosis-stratified correlation analyses between insight dimensions and depressive symptom factors. Mediation models were then applied to examine whether diagnosis-specific ED psychopathology accounted for significant associations.
Results
Three depressive dimensions were identified: emotional, apathetic, and self-critical, explaining 56.26% of the variance. In AN, affective distress was associated with poorer insight into hypothetical contradiction and treatment engagement, whereas negative self-cognitions where associated with better recognition and relabeling of ED pathology. In BN, depressive symptoms were associated with reduced insight into body weight concerns and treatment engagement. ED–specific psychopathology significantly mediated the relationship between depressive symptoms and insight in both AN and BN.
Conclusion
These findings reveal that depressive symptoms and insight are associated in distinct patterns in anorexia and bulimia, and appear to be linked through different ED-specific psychopathological pathways. Highlighting these diagnosis-specific associations contributes to a more nuanced understanding of insight in EDs and underscores the need for tailored clinical approaches.
{"title":"Insight and depressive symptoms in eating disorders: the mediating role of disorder-specific psychopathology","authors":"Leonor P. Gawron , Maria J. Portella , Esther Pousa","doi":"10.1016/j.psychres.2026.116965","DOIUrl":"10.1016/j.psychres.2026.116965","url":null,"abstract":"<div><h3>Objective</h3><div>To study whether the insight described in psychosis also occurs in eating disorders (EDs), whether it differs between anorexia nervosa (AN) and bulimia nervosa (BN), and whether diagnosis-specific ED psychopathology mediates this relationship.</div></div><div><h3>Methods</h3><div>Cross-sectional baseline data from a prospective cohort of 103 day-hospital patients with AN or BN were analyzed. Standardized measures of insight, depressive symptoms, and ED psychopathology were administered. Exploratory factor analysis was conducted on depressive symptoms, followed by diagnosis-stratified correlation analyses between insight dimensions and depressive symptom factors. Mediation models were then applied to examine whether diagnosis-specific ED psychopathology accounted for significant associations.</div></div><div><h3>Results</h3><div>Three depressive dimensions were identified: emotional, apathetic, and self-critical, explaining 56.26% of the variance. In AN, affective distress was associated with poorer insight into hypothetical contradiction and treatment engagement, whereas negative self-cognitions where associated with better recognition and relabeling of ED pathology. In BN, depressive symptoms were associated with reduced insight into body weight concerns and treatment engagement. ED–specific psychopathology significantly mediated the relationship between depressive symptoms and insight in both AN and BN.</div></div><div><h3>Conclusion</h3><div>These findings reveal that depressive symptoms and insight are associated in distinct patterns in anorexia and bulimia, and appear to be linked through different ED-specific psychopathological pathways. Highlighting these diagnosis-specific associations contributes to a more nuanced understanding of insight in EDs and underscores the need for tailored clinical approaches.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116965"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-29DOI: 10.1016/j.psychres.2026.116983
Adrian Loerbroks , Liwei Chen , Chunqing Lin , Kira Schmidt Stiedenroth , Jian Li
Objective
Prospective studies on the link between workplace discrimination and subsequent alcohol abuse remain markedly sparse. We aimed to address this gap and to expand the current evidence base by exploring i) the potential explanatory role of psychological stress and ii) gender differences.
Methods
We included 1097 workers from the Midlife in the United States (MIDUS) study without alcohol abuse at baseline (2004–2006) followed up in 2013–2014. Workplace discrimination at baseline was measured using a validated 6-item instrument and categorized into three levels by tertiles. Alcohol abuse at both baseline and follow-up was assessed using a modified 4-item Michigan Alcoholism Screening Test. We applied multivariable Poisson regression to estimate associations in terms of risk ratios (RRs) for and 95% confidence intervals (CIs). Multivariable RRs were additionally adjusted for a measure of psychological stress (i.e., Kessler 6 scale) and gender differences were examined by interaction terms.
Results
The risk of alcohol abuse was increased 2.6-fold in those reporting high workplace discrimination as compared to those with low levels (RR=2.60, 95% CI=1.10–6.15). Stress explained this association only marginally (i.e., RRs for high workplace discriminination were attenuated by 14.47%). Associations did not differ between women and men (i.e., p-values for all interaction terms were > 0.05)
Conclusion
Our findings suggest that workplace discrimination is an important risk factor for alcohol abuse among US workers, highlighting the need for organizational interventions to address discrimination at the workplace.
{"title":"Workplace discrimination and risk of alcohol abuse: a prospective cohort study in the United States","authors":"Adrian Loerbroks , Liwei Chen , Chunqing Lin , Kira Schmidt Stiedenroth , Jian Li","doi":"10.1016/j.psychres.2026.116983","DOIUrl":"10.1016/j.psychres.2026.116983","url":null,"abstract":"<div><h3>Objective</h3><div>Prospective studies on the link between workplace discrimination and subsequent alcohol abuse remain markedly sparse. We aimed to address this gap and to expand the current evidence base by exploring i) the potential explanatory role of psychological stress and ii) gender differences.</div></div><div><h3>Methods</h3><div>We included 1097 workers from the Midlife in the United States (MIDUS) study without alcohol abuse at baseline (2004–2006) followed up in 2013–2014. Workplace discrimination at baseline was measured using a validated 6-item instrument and categorized into three levels by tertiles. Alcohol abuse at both baseline and follow-up was assessed using a modified 4-item Michigan Alcoholism Screening Test. We applied multivariable Poisson regression to estimate associations in terms of risk ratios (RRs) for and 95% confidence intervals (CIs). Multivariable RRs were additionally adjusted for a measure of psychological stress (i.e., Kessler 6 scale) and gender differences were examined by interaction terms.</div></div><div><h3>Results</h3><div>The risk of alcohol abuse was increased 2.6-fold in those reporting high workplace discrimination as compared to those with low levels (RR=2.60, 95% CI=1.10–6.15). Stress explained this association only marginally (i.e., RRs for high workplace discriminination were attenuated by 14.47%). Associations did not differ between women and men (i.e., p-values for all interaction terms were > 0.05)</div></div><div><h3>Conclusion</h3><div>Our findings suggest that workplace discrimination is an important risk factor for alcohol abuse among US workers, highlighting the need for organizational interventions to address discrimination at the workplace.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116983"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-02-03DOI: 10.1016/j.psychres.2026.116995
Wen-Huei Siao , Tzong-Shi Wang , Liang-Chun Wang , Mao-Liang Chen , Yi-Chyan Chen
Background
Ketamine, a non-competitive NMDA receptor antagonist, induces dissociative and psychotomimetic states and is widely used as an animal model for schizophrenia. However, strain-dependent variability in ketamine sensitivity is poorly understood, especially during adolescence, a developmental period marked by heightened vulnerability to NMDA receptor hypofunction. This study would compare differences in pharmacological susceptibility to ketamine among different mouse strains.
Methods
The four mouse strains—C57BL/6 J, DBA, BALB/c, and 129S1—were acclimated during adolescence. A novel open-field test equipped with a video-tracking system was employed as the primary method to assess motor behavioral changes. Following a 30 min baseline free-running session, mice received intraperitoneal injections of ketamine at doses of 0, 25, or 50 mg/kg, and their activity was monitored for an additional 60 min.
Results
The results revealed distinct pharmacological reactions to ketamine, influenced by both dose and strain. Locomotor activity varied significantly among the four strains before and after ketamine treatment (p < 0.001), with activity levels ranked as follows: C57BL/6J > DBA = BALB/c > 129S1. Ketamine produced dose-dependent robust hyperlocomotion in C57BL/6 J mice, transient excitation in DBA mice at 25 mg/kg, and delayed excitation in BALB/c mice at 50 mg/kg. 129S1 mice showed minimal net changes across doses.
Conclusion
The study findings highlight diverse neurobehavioral characteristics among different mouse strains, demonstrating that pharmacological responses to ketamine are modulated by both dose and genetic background. These results indicate variability in ketamine sensitivity across strains, which may be relevant for understanding individual differences in behavioral responses to ketamine during adolescence.
{"title":"Biological variations in ketamine sensitivity: insights from hyperlocomotion to psychotomimetic features in genetically diverse mouse strains","authors":"Wen-Huei Siao , Tzong-Shi Wang , Liang-Chun Wang , Mao-Liang Chen , Yi-Chyan Chen","doi":"10.1016/j.psychres.2026.116995","DOIUrl":"10.1016/j.psychres.2026.116995","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine, a non-competitive NMDA receptor antagonist, induces dissociative and psychotomimetic states and is widely used as an animal model for schizophrenia. However, strain-dependent variability in ketamine sensitivity is poorly understood, especially during adolescence, a developmental period marked by heightened vulnerability to NMDA receptor hypofunction. This study would compare differences in pharmacological susceptibility to ketamine among different mouse strains.</div></div><div><h3>Methods</h3><div>The four mouse strains—C57BL/6 J, DBA, BALB/c, and 129S1—were acclimated during adolescence. A novel open-field test equipped with a video-tracking system was employed as the primary method to assess motor behavioral changes. Following a 30 min baseline free-running session, mice received intraperitoneal injections of ketamine at doses of 0, 25, or 50 mg/kg, and their activity was monitored for an additional 60 min.</div></div><div><h3>Results</h3><div>The results revealed distinct pharmacological reactions to ketamine, influenced by both dose and strain. Locomotor activity varied significantly among the four strains before and after ketamine treatment (<em>p</em> < 0.001), with activity levels ranked as follows: <strong>C57BL/6J > DBA = BALB/<em>c</em> > 129S1</strong>. Ketamine produced dose-dependent robust hyperlocomotion in C57BL/6 J mice, transient excitation in DBA mice at 25 mg/kg, and delayed excitation in BALB/c mice at 50 mg/kg. 129S1 mice showed minimal net changes across doses.</div></div><div><h3>Conclusion</h3><div>The study findings highlight diverse neurobehavioral characteristics among different mouse strains, demonstrating that pharmacological responses to ketamine are modulated by both dose and genetic background. These results indicate variability in ketamine sensitivity across strains, which may be relevant for understanding individual differences in behavioral responses to ketamine during adolescence.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116995"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-18DOI: 10.1016/j.psychres.2026.116953
Doron Amsalem , Chana T. Fisch , John C. Markowitz , Amit Lazarov , Yossi Levi-Belz , Ido Lurie , Milton L. Wainberg , Shlomo Mendlovic , Yuval Neria , Shilat Haim-Nachum
Background
Research has linked war-related stressors like traumatic loss, forced displacement, and income disruption to acute mental health symptoms. Little is known about how symptoms evolve longitudinally during prolonged conflict. Extending our 90-day studies, we tracked clinical symptoms and betrayal-based moral injury over one full year following the October 7, 2023, attack and ensuing war in Israel. We hypothesized stressor-exposed individuals would report persistent psychological distress and heightened betrayal perceptions one year later.
Methods
A four-wave longitudinal study followed 1,052 individuals aged 18–40 living in northern and southern Israel, areas heavily affected by October 7 and the ongoing war. Assessments occurred in February, March, and May 2024 and March 2025. Anxiety, depression, and Post-Traumatic Stress Disorder (PTSD) symptoms The Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Primary Care PTSD (PC-PTSD) measured. The Moral Injury Events betrayal subscale assessed betrayal-based moral injury. Linear Mixed Models examined symptom trajectories and associations with baseline war-related traumatic loss, forced displacement, and income loss.
Results
At baseline, 75 % of participants reported ≥1 probable clinical condition. Symptoms remained high after 12 months (66 %). Baseline exposure to traumatic loss, displacement, or income loss correlated with significantly higher anxiety, depression, PTSD, and betrayal scores across timepoints (F values 14.4-243.9, p<.001). Depression symptoms remained steady over time, whereas betrayal scores significantly increased.
Conclusions
This one-year longitudinal study found initial traumatic stressors predicted persistently elevated anxiety, depression, PTSD, and betrayal-based moral injury. Findings highlight the lasting psychological impact of cumulative war-related adversity and call for innovative, sustained treatment strategies that address both acute and evolving effects of prolonged conflict.
{"title":"A year into the war: Longitudinal effects of trauma, displacement, and income loss on mental health in conflict zones","authors":"Doron Amsalem , Chana T. Fisch , John C. Markowitz , Amit Lazarov , Yossi Levi-Belz , Ido Lurie , Milton L. Wainberg , Shlomo Mendlovic , Yuval Neria , Shilat Haim-Nachum","doi":"10.1016/j.psychres.2026.116953","DOIUrl":"10.1016/j.psychres.2026.116953","url":null,"abstract":"<div><h3>Background</h3><div>Research has linked war-related stressors like traumatic loss, forced displacement, and income disruption to acute mental health symptoms. Little is known about how symptoms evolve longitudinally during prolonged conflict. Extending our 90-day studies, we tracked clinical symptoms and betrayal-based moral injury over one full year following the October 7, 2023, attack and ensuing war in Israel. We hypothesized stressor-exposed individuals would report persistent psychological distress and heightened betrayal perceptions one year later.</div></div><div><h3>Methods</h3><div>A four-wave longitudinal study followed 1,052 individuals aged 18–40 living in northern and southern Israel, areas heavily affected by October 7 and the ongoing war. Assessments occurred in February, March, and May 2024 and March 2025. Anxiety, depression, and Post-Traumatic Stress Disorder (PTSD) symptoms The Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Primary Care PTSD (PC-PTSD) measured. The Moral Injury Events betrayal subscale assessed betrayal-based moral injury. Linear Mixed Models examined symptom trajectories and associations with baseline war-related traumatic loss, forced displacement, and income loss.</div></div><div><h3>Results</h3><div>At baseline, 75 % of participants reported ≥1 probable clinical condition. Symptoms remained high after 12 months (66 %). Baseline exposure to traumatic loss, displacement, or income loss correlated with significantly higher anxiety, depression, PTSD, and betrayal scores across timepoints (F values 14.4-243.9, <em>p</em><.001). Depression symptoms remained steady over time, whereas betrayal scores significantly increased.</div></div><div><h3>Conclusions</h3><div>This one-year longitudinal study found initial traumatic stressors predicted persistently elevated anxiety, depression, PTSD, and betrayal-based moral injury. Findings highlight the lasting psychological impact of cumulative war-related adversity and call for innovative, sustained treatment strategies that address both acute and evolving effects of prolonged conflict.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116953"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-15DOI: 10.1016/j.psychres.2026.116950
Jimin Lee, Yuna Oh, Sungeun You
Background
Identification of individuals at elevated risk for suicidal behavior is an important component of suicide prevention efforts. This study aimed to examine the predictive validity of the Acute Suicidal Affective Disturbance Inventory (ASADI) and to explore potential cutoff scores in relation to subsequent suicidal outcomes
Methods
We analyzed data from a community-based sample of 682 Korean adults who have experienced drastic increase in suicide intent, of whom 373 completed a one-year follow-up assessment. Using a one-year longitudinal data, receiver operating characteristics (ROC) analyses were conducted to examine cutoff scores in predicting future suicide attempts and suicidal ideation with intent. Potential cutoff scores were further evaluated by assessing their predictive performance after controlling for demographic and clinical covariates through multivariate logistic regression.
Results
Higher ASADI scores were prospectively associated with suicide attempts and suicidal ideation with intent during the follow-up period. A cutoff score of 248 demonstrated the strongest discriminative performance for suicide attempts, with individuals scoring above this threshold showing an increased likelihood of attempting suicide over one year after adjusting for covariates. Additional cutoffs of 192 and 206 were associated with suicidal ideation with intent.
Conclusion
These findings provide preliminary, empirically derived cutoff scores for the ASADI and support its prospective relevance as a measure of identifying at-risk individuals who warrant closer monitoring.
{"title":"Cutoff scores and predictive validity of the Acute Suicidal Affective Disturbance Inventory (ASADI) for future suicide attempts and suicidal ideation with intent","authors":"Jimin Lee, Yuna Oh, Sungeun You","doi":"10.1016/j.psychres.2026.116950","DOIUrl":"10.1016/j.psychres.2026.116950","url":null,"abstract":"<div><h3>Background</h3><div>Identification of individuals at elevated risk for suicidal behavior is an important component of suicide prevention efforts. This study aimed to examine the predictive validity of the Acute Suicidal Affective Disturbance Inventory (ASADI) and to explore potential cutoff scores in relation to subsequent suicidal outcomes</div></div><div><h3>Methods</h3><div>We analyzed data from a community-based sample of 682 Korean adults who have experienced drastic increase in suicide intent, of whom 373 completed a one-year follow-up assessment. Using a one-year longitudinal data, receiver operating characteristics (ROC) analyses were conducted to examine cutoff scores in predicting future suicide attempts and suicidal ideation with intent. Potential cutoff scores were further evaluated by assessing their predictive performance after controlling for demographic and clinical covariates through multivariate logistic regression.</div></div><div><h3>Results</h3><div>Higher ASADI scores were prospectively associated with suicide attempts and suicidal ideation with intent during the follow-up period. A cutoff score of 248 demonstrated the strongest discriminative performance for suicide attempts, with individuals scoring above this threshold showing an increased likelihood of attempting suicide over one year after adjusting for covariates. Additional cutoffs of 192 and 206 were associated with suicidal ideation with intent.</div></div><div><h3>Conclusion</h3><div>These findings provide preliminary, empirically derived cutoff scores for the ASADI and support its prospective relevance as a measure of identifying at-risk individuals who warrant closer monitoring.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116950"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-02-02DOI: 10.1016/j.psychres.2026.116990
Xue Yang , Yalin Zheng
Internet Gaming Disorder (IGD) is prevalent in adolescents and is treatable. Mindfulness-based therapy can benefit addictive behaviors, craving, and emotion regulation. However, evidence on its effectiveness in treating IGD is still lacking. This study aims to test its feasibility and effectiveness in adolescents with IGD. In total, 23 secondary school students finished the 4-week group-based intervention. At posttest, participants reported significantly lower levels of IGD symptoms (mean difference=1.13), craving (mean difference=0.38), and higher levels of emotion regulation (mean difference=–6.91) compared with pre-test. In general, participants rated the intervention positively. The response summary to the open-ended question indicated that participants favored the in-session mindfulness exercises. Suggestions to improve the intervention design were also provided. The current intervention is low cost and time-efficient with high completion rates and acceptability in adolescents with IGD. Future work may further adopt randomized control trial designs and explore the long-term effects of mindfulness-based interventions for IGD.
{"title":"Mindfulness-based therapy for adolescent internet gaming disorder: A feasibility and pilot study","authors":"Xue Yang , Yalin Zheng","doi":"10.1016/j.psychres.2026.116990","DOIUrl":"10.1016/j.psychres.2026.116990","url":null,"abstract":"<div><div>Internet Gaming Disorder (IGD) is prevalent in adolescents and is treatable. Mindfulness-based therapy can benefit addictive behaviors, craving, and emotion regulation. However, evidence on its effectiveness in treating IGD is still lacking. This study aims to test its feasibility and effectiveness in adolescents with IGD. In total, 23 secondary school students finished the 4-week group-based intervention. At posttest, participants reported significantly lower levels of IGD symptoms (mean difference=1.13), craving (mean difference=0.38), and higher levels of emotion regulation (mean difference=–6.91) compared with pre-test. In general, participants rated the intervention positively. The response summary to the open-ended question indicated that participants favored the in-session mindfulness exercises. Suggestions to improve the intervention design were also provided. The current intervention is low cost and time-efficient with high completion rates and acceptability in adolescents with IGD. Future work may further adopt randomized control trial designs and explore the long-term effects of mindfulness-based interventions for IGD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116990"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-19DOI: 10.1016/j.psychres.2026.116962
Jenny Rickardsson , Mark J. Taylor , Paul Lichtenstein , Henrik Larsson , Sebastian Lundström , Karin Jensen , Maria Lalouni
Individuals who self-harm are often insensitive to pain, and consequently pain sensitivity has been proposed as a barrier for self-harm. It is unclear how pain and self-harm interplay in real life settings, and to what extent genetics and environmental factors contribute to the etiology of both.
This study was registry based using classical twin design. A cohort of 16 948 Swedish twin pairs born between 1992 and 2010, was prospectively assessed for pain symptoms at ages 9 and 18, and followed up for later self-harm until 2016 and a maximum age of 24.
The relative contributions of genetic and environmental factors to each phenotype were estimated using univariate twin models. Logistic regression models assessed their association, and conditional models adjusted for familial confounding.
Genetics and non-shared environment contributed to pain and self-harm to a moderate degree at both age 9 and age 18, while the contribution of shared environment was small for both pain and self-harm at both ages. At age 18 the pain symptoms group had higher odds for later self-harm (odds ratio 1.59, 95% CI 1.06–2.41, p = .003), and pain seemed to be partially in the causal pathway as it was not explained by familial confounding. This study adds to the evidence of pain symptoms as a predictor for self-harm.
自我伤害的个体通常对疼痛不敏感，因此疼痛敏感性被认为是自我伤害的障碍。目前还不清楚疼痛和自我伤害在现实生活中是如何相互作用的，也不清楚遗传和环境因素在多大程度上影响了两者的病因。本研究采用经典双胞胎设计。对1992年至2010年间出生的16948对瑞典双胞胎进行了前瞻性评估，评估了他们在9岁和18岁时的疼痛症状，并对后来的自我伤害进行了随访，直到2016年，最大年龄为24岁。使用单变量双胞胎模型估计遗传和环境因素对每种表型的相对贡献。逻辑回归模型评估了它们之间的关联，条件模型对家族混淆进行了调整。在9岁和18岁时，遗传和非共享环境对疼痛和自残都有中等程度的影响，而共享环境对疼痛和自残的影响都很小。在18岁时，疼痛症状组后来自残的几率更高（优势比1.59,95% CI 1.06-2.41, p = 0.003），疼痛似乎是部分因果途径，因为它不能用家族混淆来解释。这项研究进一步证明，疼痛症状是自我伤害的前兆。
{"title":"Genetic and environmental factors in pain symptoms and self-harm, and their association. A twin study","authors":"Jenny Rickardsson , Mark J. Taylor , Paul Lichtenstein , Henrik Larsson , Sebastian Lundström , Karin Jensen , Maria Lalouni","doi":"10.1016/j.psychres.2026.116962","DOIUrl":"10.1016/j.psychres.2026.116962","url":null,"abstract":"<div><div>Individuals who self-harm are often insensitive to pain, and consequently pain sensitivity has been proposed as a barrier for self-harm. It is unclear how pain and self-harm interplay in real life settings, and to what extent genetics and environmental factors contribute to the etiology of both.</div><div>This study was registry based using classical twin design. A cohort of 16 948 Swedish twin pairs born between 1992 and 2010, was prospectively assessed for pain symptoms at ages 9 and 18, and followed up for later self-harm until 2016 and a maximum age of 24.</div><div>The relative contributions of genetic and environmental factors to each phenotype were estimated using univariate twin models. Logistic regression models assessed their association, and conditional models adjusted for familial confounding.</div><div>Genetics and non-shared environment contributed to pain and self-harm to a moderate degree at both age 9 and age 18, while the contribution of shared environment was small for both pain and self-harm at both ages. At age 18 the pain symptoms group had higher odds for later self-harm (odds ratio 1.59, 95% CI 1.06–2.41, <em>p</em> = .003), and pain seemed to be partially in the causal pathway as it was not explained by familial confounding. This study adds to the evidence of pain symptoms as a predictor for self-harm.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116962"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146066513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-30DOI: 10.1016/j.psychres.2026.116989
Lisha Zhang , Kun Qin , Nanfang Pan , Haoran Xu , Qiyong Gong
As a central hub of emotional processing, alterations in amygdala functional connectivity (FC) have garnered significant attention in both major depressive disorder (MDD) and bipolar disorder (BD), which holds promise in identifying differential biomarkers and highlighting their similarities. However, current findings are limited by inconsistency. To address this, we conducted a comparative and conjunction analysis using the Seed-based d Mapping (SDM) toolbox to examine amygdala FC alterations in MDD and BD patients. Our results revealed distinct amygdala FC alterations between MDD and BD were primarily identified in the left temporal pole, cingulate cortex, and left supramarginal gyrus, while shared amygdala FC abnormalities were particularly observed in the fronto-limbic regions and occipitotemporal gyrus. These findings highlight both commonalities and differences in amygdala FC alterations across MDD and BD, providing insights into the underlying pathophysiology of mood disorders and offering potential neural biomarkers for differential diagnosis, thereby aiding in the improvement of treatment strategies.
{"title":"Common and distinct patterns of aberrant amygdala functional connectivity in major depressive disorder and bipolar disorder: A voxel-wise comparative meta-analysis","authors":"Lisha Zhang , Kun Qin , Nanfang Pan , Haoran Xu , Qiyong Gong","doi":"10.1016/j.psychres.2026.116989","DOIUrl":"10.1016/j.psychres.2026.116989","url":null,"abstract":"<div><div>As a central hub of emotional processing, alterations in amygdala functional connectivity (FC) have garnered significant attention in both major depressive disorder (MDD) and bipolar disorder (BD), which holds promise in identifying differential biomarkers and highlighting their similarities. However, current findings are limited by inconsistency. To address this, we conducted a comparative and conjunction analysis using the Seed-based d Mapping (SDM) toolbox to examine amygdala FC alterations in MDD and BD patients. Our results revealed distinct amygdala FC alterations between MDD and BD were primarily identified in the left temporal pole, cingulate cortex, and left supramarginal gyrus, while shared amygdala FC abnormalities were particularly observed in the fronto-limbic regions and occipitotemporal gyrus. These findings highlight both commonalities and differences in amygdala FC alterations across MDD and BD, providing insights into the underlying pathophysiology of mood disorders and offering potential neural biomarkers for differential diagnosis, thereby aiding in the improvement of treatment strategies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116989"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-27DOI: 10.1016/j.psychres.2026.116977
Lilit Antonyan , S-M Shaheen , Christie L. Burton , William J. Gehring , Noam Soreni , Pamela Falzarano Szura , Julia Bellamy , Usha Rajan , David Rosenberg , Gregory L. Hanna , Paul D. Arnold
Here, we present the first genome-wide association study and polygenic risk score analysis of obsessive-compulsive symptoms in a sample of 661 clinically diagnosed pediatric participants diagnosed with mental illness and healthy controls. Using a psychiatric questionnaire score as a quantitative trait we conducted a large-scale genetic analysis and ran multiple post-association analyses to investigate the mediating role of obsessive-compulsive symptoms in six comorbid mental disorders. Polygenic risk scores were computed for OCS using genome-wide summary statistics from obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, anxiety disorders, depression, autism spectrum disorder, and tic disorders. Across all models, the PRS of OCS explained modest yet significant proportion of shared genetic risk across six mental disorders consistent with effect sizes typically observed in complex psychiatric traits. Furthermore, Mendelian randomization analysis suggested a potential causal pathway in which OCS mediates the genetic risk for anxiety. These findings highlight shared polygenic mechanisms between OCS and a range of neuropsychiatric conditions. We observed a potential causal pathway in which OCS mediates the genetic risk for anxiety, supporting the hypothesis that OCS may serve as a transdiagnostic mediator within the pediatric population. This study underscores the value of examining genetic risk across the symptom spectrum of mental illnesses, rather than relying solely on binary diagnostic categories.
{"title":"Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders","authors":"Lilit Antonyan , S-M Shaheen , Christie L. Burton , William J. Gehring , Noam Soreni , Pamela Falzarano Szura , Julia Bellamy , Usha Rajan , David Rosenberg , Gregory L. Hanna , Paul D. Arnold","doi":"10.1016/j.psychres.2026.116977","DOIUrl":"10.1016/j.psychres.2026.116977","url":null,"abstract":"<div><div>Here, we present the first genome-wide association study and polygenic risk score analysis of obsessive-compulsive symptoms in a sample of 661 clinically diagnosed pediatric participants diagnosed with mental illness and healthy controls. Using a psychiatric questionnaire score as a quantitative trait we conducted a large-scale genetic analysis and ran multiple post-association analyses to investigate the mediating role of obsessive-compulsive symptoms in six comorbid mental disorders. Polygenic risk scores were computed for OCS using genome-wide summary statistics from obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, anxiety disorders, depression, autism spectrum disorder, and tic disorders. Across all models, the PRS of OCS explained modest yet significant proportion of shared genetic risk across six mental disorders consistent with effect sizes typically observed in complex psychiatric traits. Furthermore, Mendelian randomization analysis suggested a potential causal pathway in which OCS mediates the genetic risk for anxiety. These findings highlight shared polygenic mechanisms between OCS and a range of neuropsychiatric conditions. We observed a potential causal pathway in which OCS mediates the genetic risk for anxiety, supporting the hypothesis that OCS may serve as a transdiagnostic mediator within the pediatric population. This study underscores the value of examining genetic risk across the symptom spectrum of mental illnesses, rather than relying solely on binary diagnostic categories.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116977"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号