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Does hair cortisol concentration reflect saliva cortisol levels and/or the regulatory biology of the HPA axis that shapes them in healthy humans?
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107321
G Liberzon , S.L. Clark , J.L. Abelson
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引用次数: 0
Presentation 1: Childhood adversity and adult depressive symptoms: body mass index and interleukin-6 as sequential mediators in a structural equation modeling meta-analysis
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107299
A. Zagaria , V Fiori , M. Vacca , C. Lombardo , C.M. Pariante , A. Ballesio
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引用次数: 0
The healing power of love: The oxytocin-sociostasis hypothesis
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107288
C.S. Carter
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引用次数: 0
Prediction of adolescent depression from demographic, clinical, and survey data from ALSPAC using machine learning
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107293
C.E. Hostinar , A. Yoo, F. Li, J. Youn, J. Guan, A. E. Guyer, I. Tagkopoulos
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引用次数: 0
History of sexual abuse predicts distinct diurnal cortisol slopes in incarcerated girls and boys
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107328
C. Lavassani , M. Johnson , P. Ruttle , A. Dismukes , O. Miočević , E. Shirtcliff
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引用次数: 0
The impact of objective and subjective socioeconomic status on prenatal sleep: cross-cultural findings from birth cohorts in the us and turkey
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107350
S. Muftareviç , Ö. Aran , M. Nevarez-Brewster , B.L. Hankin , E.P. Davis , E.A. Duman
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引用次数: 0
The role of extracellular vesicle miR-16-5p in mediating long-term effects of childhood trauma
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107352
Yangyang He , Karin Wuertz-Kozak , Sanne Houtenbos , Pia-Maria Wippert
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引用次数: 0
Allostatic load as a valuable biomarker in physical activity and nutrition research
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107313
A.I. Turner , E. Hart , R.V. K. Siew , S.J. Lupien , C. Margerison , C.G. Russell , S.J. Torres , L.C. Main , M. Teychenne
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引用次数: 0
Share-the-load vs bring-your-own-judge: The effects of friends on social evaluative stress in early adolescence 分担负担vs自带评判:朋友对青少年早期社会评价压力的影响。
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107254
Clarissa R. Filetti, Nikola C. Tsakonas, Bonny Donzella, Kathleen M. Thomas, Megan R. Gunnar

Objective

Parental attachment figures effectively buffer their children’s cortisol responses to a socially evaluative stressor, the Trier Social Stress Test (TSST), by providing instrumental and emotional support during the preparation period. The effectiveness of parents as stress buffers wanes in adolescence as youth increase their reliance on peers for support. Yet, in a previous study, when peers played the same supportive role as parents, the cortisol response to the TSST was amplified. Here we asked if the role the friend plays matters. We hypothesized that the support of a friend would reduce the cortisol response to the TSST if they were also undergoing the stressor; while friend support would increase the cortisol response if they were only there for support and were not also undergoing the stressor.

Method

235 youth ages 11.2–15.1 years were tested in the TSST-OL, an on-line version of the TSST task. Saliva samples were obtained for cortisol determination at multiple timepoints. In this pre-registered study, youth were randomly assigned, stratified by age, sex assigned at birth and pubertal status (early/later), to one of the following conditions: 1) Alone, 2) Unfamiliar Peer – Both Tested, 3) Friend as Supporter, 4) Friend – Both Tested.

Results

Area under the curve from intercept (AUCi) for the initial reactivity phase was significantly different by group, matching our pre-registered prediction that friend support would reduce reactivity if both friends were undergoing the stressor, but increase it if the friend providing support did not also undergo the stressor. Recovery did not differ by condition.

Conclusions

The effect of friends as stress buffers varies by the role the friend plays. In the case of the TSST, a social evaluative stressor, support from a friend buffers cortisol reactivity if the friend is also experiencing the stressor; but increases cortisol reactivity if they are just there as a support. Simply being with a supportive friend does not shield the adolescent from reacting with a neuroendocrine stress response to the stress of social evaluation.
目的:父母依恋人物通过在准备阶段提供工具和情感支持,有效缓冲孩子对社会评价性压力源Trier社会压力测试(TSST)的皮质醇反应。随着青少年越来越依赖同伴的支持,父母作为压力缓冲的有效性在青春期减弱。然而,在之前的一项研究中,当同伴扮演与父母相同的支持角色时,皮质醇对TSST的反应被放大了。这里我们问的是朋友扮演的角色是否重要。我们假设朋友的支持会降低他们对TSST的皮质醇反应,如果他们也经历了压力源;而朋友的支持会增加皮质醇的反应,如果他们只是在那里寻求支持,而不是经历压力源。方法:对235名年龄在11.2 ~ 15.1岁的青少年进行在线TSST- ol测试。在多个时间点获得唾液样本用于皮质醇测定。在这项预先登记的研究中,青少年被随机分配,按年龄、出生时的性别和青春期状态(早/晚)分层,到以下条件之一:1)孤独,2)不熟悉的同伴-都测试,3)朋友作为支持者,4)朋友-都测试。结果:初始反应阶段的截距曲线下面积(AUCi)组间差异显著,符合我们的预登记预测,即如果朋友双方都经历了压力源,朋友的支持会降低反应性,但如果提供支持的朋友没有经历压力源,则会增加反应性。恢复情况没有因条件而异。结论:朋友作为压力缓冲的作用因其所扮演的角色而异。在TSST(一种社会评价性压力源)的情况下,如果朋友也在经历压力源,来自朋友的支持会缓冲皮质醇反应;但如果它们只是作为支持,就会增加皮质醇的反应。仅仅和一个支持他们的朋友在一起并不能保护青少年免受神经内分泌压力对社会评价压力的反应。
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引用次数: 0
HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents 母乳喂养与奶瓶喂养父母的 HPA 轴失调以及产后抑郁和焦虑症状。
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107253
Katharine E. Bruce , Kathryn Wouk , Karen M. Grewen , Brenda Pearson , Samantha Meltzer-Brody , Alison M. Stuebe , Anna E. Bauer

Objective

Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in the pathogenesis of perinatal mood disorders. Further, HPA axis response is known to be blunted during breastfeeding. We hypothesized that 1) postpartum depression/anxiety symptoms would be associated with HPA axis dysregulation, indexed by loss of expected adrenocorticotropic hormone (ACTH)-cortisol coupling, and 2) this association would vary by method of infant feeding.

Methods

Participants (N=222) intending to breastfeed were recruited in their 3rd trimester of pregnancy. During a lab visit at 2 months postpartum, depression and anxiety symptoms were assessed (Beck Depression Inventory score ≥14 and/or Speilberger State-Trait Anxiety Inventory score ≥40). Participants then breast or bottle-fed their infants as they would at home. After a 10-minute rest, participants completed the Trier Social Stress Test (TSST), a standardized stressor involving speech and math tasks. Blood ACTH and cortisol were measured 10 minutes after feeding, during each task, and at 10, 20, and 30 minutes of recovery. Multilevel models evaluated whether coupling of ACTH at time j with cortisol at time j+1 differed between those with and without depression/anxiety symptoms, and whether differences varied by feeding method.

Results

Of 205 participants who completed the TSST, 44 had depression/anxiety symptoms at 2-months postpartum. Depression/anxiety symptoms were associated with reduced ACTH-cortisol coupling (adjusted beta: −0.03; p-value: 0.03). Among those who breastfed, those with depression/anxiety showed greater blunting of ACTH-cortisol coupling than those without (adjusted beta: −0.04; p-value: 0.02), while those who bottle-fed had similar coupling patterns regardless of depression/anxiety symptoms (adjusted beta: −0.01; p-value: 0.87).

Conclusion

HPA axis response was blunted in those with postpartum depression/anxiety symptoms, and blunting varied by method of infant feeding. Findings support HPA axis dysregulation in perinatal mood and anxiety disorders. Future research should explore how method of infant feeding influences the relationship between perinatal mood disorders and HPA axis dysregulation. Elucidating the mechanistic pathways underlying perinatal mood disorders can aid in the development of better diagnostic and treatment strategies.
目的:下丘脑-垂体-肾上腺(HPA)轴失调与围产期情绪障碍的发病机制有关。此外,众所周知,母乳喂养期间 HPA 轴的反应会减弱。我们假设:1)产后抑郁/焦虑症状将与 HPA 轴失调有关,以预期促肾上腺皮质激素(ACTH)-皮质醇耦合的丧失为指标;2)这种关联将因婴儿喂养方式而异:方法:在怀孕三个月时招募打算母乳喂养的参与者(N=222)。在产后 2 个月的实验室访问期间,对抑郁和焦虑症状进行了评估(贝克抑郁量表得分≥14 和/或斯皮尔伯格状态-特质焦虑量表得分≥40)。然后,参与者像在家里一样用母乳或奶瓶喂养婴儿。休息10分钟后,参与者完成特里尔社会压力测试(TSST),这是一项标准化压力测试,包括语言和数学任务。在喂奶后 10 分钟、完成每项任务期间以及恢复后 10 分钟、20 分钟和 30 分钟分别测量了血液中的促肾上腺皮质激素和皮质醇。多层次模型评估了有抑郁/焦虑症状和无抑郁/焦虑症状的人在第j个时间的促肾上腺皮质激素与第j+1个时间的皮质醇的耦合是否存在差异,以及差异是否因喂食方法而异:在完成 TSST 的 205 名参与者中,有 44 人在产后 2 个月出现抑郁/焦虑症状。抑郁/焦虑症状与促肾上腺皮质激素-皮质醇耦合降低有关(调整后的β值:-0.03;P值:0.03)。在母乳喂养者中,有抑郁/焦虑症状者比无抑郁/焦虑症状者表现出更大的促肾上腺皮质激素-皮质醇耦合钝化(调整后的贝塔值:-0.04;P值:0.02),而奶瓶喂养者无论是否有抑郁/焦虑症状,其耦合模式相似(调整后的贝塔值:-0.01;P值:0.87):结论:产后抑郁/焦虑症状患者的 HPA 轴反应迟钝,且迟钝程度因婴儿喂养方式而异。研究结果支持围产期情绪和焦虑障碍中的 HPA 轴失调。未来的研究应探讨婴儿喂养方式如何影响围产期情绪障碍与 HPA 轴调节失调之间的关系。阐明围产期情绪障碍的机制途径有助于制定更好的诊断和治疗策略。
{"title":"HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents","authors":"Katharine E. Bruce ,&nbsp;Kathryn Wouk ,&nbsp;Karen M. Grewen ,&nbsp;Brenda Pearson ,&nbsp;Samantha Meltzer-Brody ,&nbsp;Alison M. Stuebe ,&nbsp;Anna E. Bauer","doi":"10.1016/j.psyneuen.2024.107253","DOIUrl":"10.1016/j.psyneuen.2024.107253","url":null,"abstract":"<div><h3>Objective</h3><div>Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in the pathogenesis of perinatal mood disorders. Further, HPA axis response is known to be blunted during breastfeeding. We hypothesized that 1) postpartum depression/anxiety symptoms would be associated with HPA axis dysregulation, indexed by loss of expected adrenocorticotropic hormone (ACTH)-cortisol coupling, and 2) this association would vary by method of infant feeding.</div></div><div><h3>Methods</h3><div>Participants (N=222) intending to breastfeed were recruited in their 3rd trimester of pregnancy. During a lab visit at 2 months postpartum, depression and anxiety symptoms were assessed (Beck Depression Inventory score ≥14 and/or Speilberger State-Trait Anxiety Inventory score ≥40). Participants then breast or bottle-fed their infants as they would at home. After a 10-minute rest, participants completed the Trier Social Stress Test (TSST), a standardized stressor involving speech and math tasks. Blood ACTH and cortisol were measured 10 minutes after feeding, during each task, and at 10, 20, and 30 minutes of recovery. Multilevel models evaluated whether coupling of ACTH at time j with cortisol at time j+1 differed between those with and without depression/anxiety symptoms, and whether differences varied by feeding method.</div></div><div><h3>Results</h3><div>Of 205 participants who completed the TSST, 44 had depression/anxiety symptoms at 2-months postpartum. Depression/anxiety symptoms were associated with reduced ACTH-cortisol coupling (adjusted beta: −0.03; p-value: 0.03). Among those who breastfed, those with depression/anxiety showed greater blunting of ACTH-cortisol coupling than those without (adjusted beta: −0.04; p-value: 0.02), while those who bottle-fed had similar coupling patterns regardless of depression/anxiety symptoms (adjusted beta: −0.01; p-value: 0.87).</div></div><div><h3>Conclusion</h3><div>HPA axis response was blunted in those with postpartum depression/anxiety symptoms, and blunting varied by method of infant feeding. Findings support HPA axis dysregulation in perinatal mood and anxiety disorders. Future research should explore how method of infant feeding influences the relationship between perinatal mood disorders and HPA axis dysregulation. Elucidating the mechanistic pathways underlying perinatal mood disorders can aid in the development of better diagnostic and treatment strategies.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107253"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Psychoneuroendocrinology
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