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The Era of Artificial Intelligence in Pharmaceutical Industries - A Review 制药行业的人工智能时代——综述
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00030
Praveen Tahilani, H. Swami, Gaurav Goyanar, Shivani Tiwari
As a growing sector, the Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry contributes in the drug discovery process, giving emphasis on how new technologies have improved effectiveness. As in the current scenario artificial intelligence including machine learning may be considered the future for a wide range of disciplines and industries specially the pharmaceutical industry. As we know today pharmaceutical industries producing a single approved drug cost the company millions with many years of rigorous testing prior to its approval, reducing costs and time is of high interest. The involvement of Artificial Intelligence will be useful to the pharmaceutical industry and also be of interest to anyone doing research in chemical biology, computational chemistry, medicinal chemistry and bioinformatics.
作为一个不断发展的行业,制药行业的人工智能、机器学习和数据科学时代有助于药物发现过程,强调新技术如何提高有效性。在目前的情况下,包括机器学习在内的人工智能可能被认为是广泛学科和行业的未来,特别是制药行业。正如我们今天所知,制药行业生产一种批准的药物要花费公司数百万美元,在批准之前要经过多年的严格测试,减少成本和时间是非常重要的。人工智能的参与将对制药行业非常有用,也会引起化学生物学、计算化学、药物化学和生物信息学研究人员的兴趣。
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引用次数: 1
A Quantitative Study to Assess the Level of Knowledge and Attitude on Menstrual Cup Among Adolescent Girls in Selected School, Thrissur 择校少女月经杯知识与态度的定量研究[j]
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00023
Siji. C.S., Jincy M.P, A. R., Anagha P.A, Anjaly Anil, Anju V.S, Annmary Antony, Roshni Roy, S. Selvan
A menstrual cup is a device that is inserted into the vagina during menstruation. Menstrual cups have been available for decades, but there use in India is limited because of lack of awareness and popularity of sanitary pads. Since they are reusable, they reduce solid waste and are environment friendly. The need of the hour is education, awareness, and availability of the eco-friendly practices when it comes to managing menstrual waste effectively. Once it is taken care of, it will be easy for anyone to make a green switch. Hence, the study was undertaken to assess the level of knowledge and attitude on menstrual cup among adolescent girls in selected schools. Thrissur. The objectives of the study were, to assess the level of knowledge and attitude on menstrual cup among adolescent girls and to associate the level of knowledge and attitude on menstrual cup among the samples with their selected demographic variables. The design of the study was descriptive and was conducted among 50 adolescent girls from St. Sebastian School, Nellikkunnu, Thrissur. The samples were selected by using purposive sampling technique. Data was collected by using structured knowledge questionnaire regarding menstrual cup. The result showed that 2 (4%) samples had inadequate knowledge, 43 (86%) had moderate knowledge and 5 (10%) had adequate knowledge. There was no significant association between the level of knowledge regarding menstrual cup among adolescent girls with their selected demographic variables. The study also revealed that 6 (12%) had fair attitude, 43 (86%) had good attitude, 1 (2%) had excellent attitude and none of them had poor attitude on menstrual cup. There was significant association between the attitude on menstrual cup with their selected demographic variables such as age in years, area of residence and educational status of mother. The study concluded that, majority of the adolescent girls had moderate knowledge and fair attitude on menstrual cup.
月经杯是一种在月经期间插入阴道的装置。月经杯已经有几十年的历史了,但在印度,由于缺乏对卫生巾的认识和普及,月经杯的使用有限。由于它们是可重复使用的,它们减少了固体废物,对环境友好。现在需要的是教育、意识和环保实践的可用性,以便有效地管理月经废物。一旦它被照顾好,任何人都可以很容易地进行绿色转换。因此,本研究旨在评估所选学校少女对月经杯的认知和态度。场景。本研究的目的是评估青春期女孩对月经杯的知识和态度水平,并将样本中对月经杯的知识和态度水平与其所选择的人口统计学变量联系起来。该研究的设计是描述性的,研究对象是来自Thrissur, Nellikkunnu, St. Sebastian School的50名青春期女孩。采用有目的抽样技术选择样本。采用结构化的月经杯知识问卷收集数据。结果显示,2个(4%)样本知识不充分,43个(86%)样本知识中等,5个(10%)样本知识充分。少女对月经杯的了解程度与她们所选择的人口统计学变量之间没有显著的关联。对月经杯持“一般”态度者6人(12%),持“良好”态度者43人(86%),持“极好”态度者1人(2%),均无“差”态度者。她们对月经杯的态度与她们所选择的人口统计学变量如年龄、居住地区和母亲的受教育程度有显著的相关性。研究结果表明,大部分少女对月经杯的认知适度,态度公正。
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引用次数: 1
Ayurvedic Immunomodulatory Drugs showing Pharmacological effects in Healthcare System 阿育吠陀免疫调节药物在医疗保健系统中的药理作用
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00027
A. Bhoir, S. Borade, S. Borde, G. Chaudhari, V. Sharma
Ayurvedic system of medicine display a wealth of pharmacological properties. The ayurvedic system of medicine is one of the oldest systems of medicine and includes various ethno pharmacological activities such as immunostimulation, tonic, neurostimulation, anti-ageing, antibacterial, anti-viral, anti-rheumatic, anticancer, adapt genic, etc. The present review focuses on plant profile, pharmacological activities especially immunomodulation, uses (Traditional and medicinal), side effects and marketed products, and also the survey of all people who are aware, and what they consume for boosting immunity. The whole plant as well as plant parts such as the Fruit of piperlongum are used traditionally and is a flowering vine in the family Piperaceae. Asparagus racemosus is an important medicinal plant of tropical and subtropical India of family Liliaeceae. Liquorice is the most widely used herb from the ancient medical history of Ayurveda as a medicine as well as a flavoring herb with family leguminosae Guduchi is a well-known immune-modulator herb used in the correction of auto immunity of family Menispermaeceae. Turmeric is an Indian rhizomatous herbal plant (Curcuma longa) of the ginger family zingiberaceae of well-known medical benefits. The sources of review paper were PubMed, research gate, Science Direct, kokate (BOOK). However Research has been done from ancient time and various research papers are published so awareness of these drugs and ayurvedic drugs should be done for betterment of health care system.
阿育吠陀医学系统显示了丰富的药理学特性。阿育吠陀医学体系是最古老的医学体系之一,包括各种民族药理活性,如免疫刺激、滋补、神经刺激、抗衰老、抗菌、抗病毒、抗风湿病、抗癌、适应性基因等。本综述的重点是植物概况,药理学活性,特别是免疫调节,用途(传统和药用),副作用和上市产品,以及对所有知道的人的调查,以及他们为提高免疫力而食用的东西。传统上使用的是整株植物以及植物部分,如胡椒果,它是胡椒科的一种开花藤蔓植物。总状芦笋是产于印度热带和亚热带百合科的重要药用植物。甘草是阿育吠陀古代医学史上应用最广泛的一种草药,也是豆科植物的调味草药。古杜奇是一种著名的免疫调节剂,用于纠正Menispermaeceae家族的自身免疫。姜黄是一种印度根茎草本植物(姜黄长)姜科姜科的知名医疗效益。文献来源PubMed, research gate, Science Direct, kokate (BOOK)。然而,从古代开始就进行了研究,并发表了各种研究论文,因此应该对这些药物和阿育吠陀药物进行认识,以改善医疗保健系统。
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引用次数: 0
Analysis of Skin disease techniques using Smart Phone and Digital Camera Identification of Skin Disease 基于智能手机和数码相机的皮肤病识别技术分析
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00024
Skin diseases are a serious health issue that affects a large number of individuals. In recent years, with the fast advancement of technology and the use of various data mining approaches, dermatological predictive classification has become increasingly predictive and accurate. It is more help to dermatologist to identify the disease, As a result, the development of machine learning approaches capable of efficiently. The purpose of this study is making an application of identification skin disease images by using the machines learning method, Support Vector Machine (SVM), and KNN techniques. The image processes and machine learning is performed early detection of skin diseases. The aim of this study is determined the classification of skin diseases in humans. Each skin disease has symptoms. It has five skin diseases such as Acne, Psoriasis, Wrath, Psoriasis, and Ulcer. We have collected 314 skin disease images from the government of hospital, Aurangabad with the help of mobile camera and Sony HD camera. Gaussian Filter is used for image pre-processing. The segmentation method is used for K-Means Clustering and the feature extraction method are used for feature extraction. We have used Haar feature, color feature, FCM, OS-FCM, GLCM and LBF features for classifications. Based on the result, the SVM is given 92% accuracy for haar feature, FCM and OS-FCM. and KNN classifier, K-Means are given 89% and 89% accuracy using mobile phone camera dataset. The SVM, KNN and K-Means are given 91%, 87% and 89% accuracy respectively using Sony HD camera dataset. SVM is given good result in both dataset.
皮肤病是影响许多人的严重健康问题。近年来,随着技术的快速进步和各种数据挖掘方法的使用,皮肤病学预测分类的预测性和准确性越来越高。它更有助于皮肤科医生识别疾病,因此,机器学习方法的发展能够有效地解决问题。本研究的目的是利用机器学习方法、支持向量机(SVM)和KNN技术在皮肤病图像识别中的应用。通过图像处理和机器学习进行皮肤疾病的早期检测。本研究的目的是确定人类皮肤病的分类。每种皮肤病都有症状。它有五种皮肤病,如痤疮、牛皮癣、愤怒、牛皮癣和溃疡。我们在移动相机和索尼高清相机的帮助下,从奥兰加巴德政府医院收集了314张皮肤病图像。采用高斯滤波器对图像进行预处理。k均值聚类采用分割方法,特征提取采用特征提取方法。我们使用Haar特征、颜色特征、FCM、OS-FCM、GLCM和LBF特征进行分类。在此基础上,支持向量机对haar特征、FCM和OS-FCM的准确率达到92%。使用手机相机数据集,K-Means的准确率分别为89%和89%。使用索尼高清相机数据集,SVM、KNN和K-Means的准确率分别为91%、87%和89%。支持向量机在两个数据集上都得到了很好的结果。
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引用次数: 0
New System for Identification of Propranolol Tablet (Inderal) 普萘洛尔片(Inderal)的新鉴别系统
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00028
Kamalakshi Krishnamurthy, T. Zin., K. Priyamvatha, Mahadeva Rao U.S., S. M.
Various new drugs are being introduced in the market. This proves a hectic problem for Toxicologist to identify the exact nature of the drug and its metabolites in the viscera for cases involving death due to drug poisoning. When a case is taken for drug analysis, we have to be more exhaustive in ruling out drugs. For identification of Inderal tablets, a new Thin Layer chromatography system has been developed. After systematic trials, the paper has found out a new solvent system with spray for eluting Inderal tablets.
市场上正在推出各种新药。这证明了毒理学家在涉及药物中毒死亡的病例中确定药物及其代谢物在内脏中的确切性质是一个棘手的问题。在对一个病例进行药物分析时,我们必须更加彻底地排除药物。为鉴别安非他明片剂,建立了一种新的薄层色谱系统。经过系统试验,本文找到了一种新的喷雾溶剂体系,用于印得乐片的洗脱。
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引用次数: 0
Internet Service Provider Management System 互联网服务提供商管理系统
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00025
P. Muthusamy, Pratyush Pritam, Surya Prakash Verma
The purpose of the project entitled as “Internet Service Provider Management System” is to computerize the Front Office Management of any internet service provider company to develop software which is user friendly simple, fast and cost – effective Internet Service Providers are the link between users and the World Wide Web. This position gives Internet Service Providers limitless technical manage over all of the content material on the Internet. This application is built for internet and Dth service providers to manage their clients more efficiently. The major task of this web application is to provide internet and Dth services to the customers. The system will provide the details of each and every section of the data fields. So that system can store accurate data. The data can be retrieved easily. The data are well protected for personal use and makes the data processing very fast. This software can also handle multiple buildings once at a time in range of 20 KM of its radius (for Example- School, Hospital, Police Station, Post office etc.
“互联网服务提供商管理系统”项目的目的是将任何互联网服务提供商公司的前台管理电脑化,以开发用户友好、简单、快速和经济有效的软件。互联网服务提供商是用户与万维网之间的联系。这一职位赋予互联网服务提供商对互联网上所有内容的无限技术管理权。这个应用程序是为互联网和Dth服务提供商更有效地管理他们的客户而构建的。这个web应用程序的主要任务是为客户提供互联网和数字电视服务。系统将提供数据字段的每个部分的详细信息。这样系统就能存储准确的数据。数据可以很容易地检索到。个人使用的数据得到很好的保护,数据处理速度非常快。该软件还可以在其半径20公里的范围内一次处理多个建筑物(例如-学校,医院,警察局,邮局等)。
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引用次数: 0
Green Nano-catalysts and importance of green reactions in Industry: A Review 绿色纳米催化剂及其在工业中绿色反应的重要性
Pub Date : 2022-08-05 DOI: 10.52711/2349-2988.2022.00031
Siddiqua Shaikh
A Catalysis is a strategic field of science because it involves new ways of meeting energy and sustainability challenges. In the field of green chemistry, there has been a rapid increase in the use of green Nano-catalysts as well as green conditions during the catalysis of industrially relevant reactions. With the aim to avoid the use of toxic reagent, toxic volatile organic solvents, hazardous or harsh reaction conditions as well as challenging and over time-consuming wasteful separations, greener and environmentally benign catalytic protocols have recently become most popular. For the composition of green Nano catalysts is to synthesizing the Nano catalysts by using green solvents or processing the nanocatalysts so that they are finally diffuse in green solvents. The Nano-sized particles increase the exposed surface area of the highly active component of the catalyst, thereby increasing the contact between reactants and catalyst dramatically and imitate the homogeneous catalysts, Green Nano catalysis generally refers to doing the catalytic reaction in the green solvents and preferably by the use of green nanocatalysts for these reactions. This chapter is focus on green nanocatalysts as well as industrially important green reactions.
催化是一个战略性的科学领域,因为它涉及到应对能源和可持续性挑战的新方法。在绿色化学领域,绿色纳米催化剂的使用迅速增加,工业相关反应的催化过程中也出现了绿色条件。为了避免使用有毒试剂,有毒挥发性有机溶剂,危险或恶劣的反应条件以及具有挑战性和耗时浪费的分离,绿色环保的催化方案最近变得最受欢迎。绿色纳米催化剂的组成是利用绿色溶剂合成纳米催化剂或对纳米催化剂进行加工,使其最终在绿色溶剂中扩散。纳米级颗粒增加了催化剂中高活性组分的暴露表面积,从而大大增加了反应物与催化剂之间的接触,模仿了均相催化剂。绿色纳米催化一般是指在绿色溶剂中进行催化反应,最好使用绿色纳米催化剂进行这些反应。本章的重点是绿色纳米催化剂以及工业上重要的绿色反应。
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引用次数: 0
Green Technology: A Pathway towards Future Alternative Technology 绿色技术:通往未来替代技术之路
Pub Date : 2022-05-03 DOI: 10.52711/2349-2988.2022.00020
S. Dash
Green technology develops and creates a pathway for the future’s energy generations. The objective of the research is to find out different technology suitable for energy generation by not harming the environment besides protection of natural environment. With the rise of earth’s temperature day to day, depletion of energy, global warming, it is inevitable to develop some methodology of green technology to save the life and property. Environmental protections are covered with green energy which is centre for economic, social and environmental area. The fuels produced by different sources like oil, coal and natural gases are trying to become an efficient engine for economic progress but at the same time they are harmful for the environment and also harms health that confronts with the global energy requirement. Every sector utilizing energy from agriculture to construction of house, green technology is has made its application for the sake of sustainable development without harming the environment. With the rise of industrial growth bringing development of the society that leads to problematic with the emission of green-house gases into the atmospheres making the water unfit for consumption as well as for the air used for breathing. Hence Green technology is a appropriate pathway towards future’s alternative technology.
绿色技术的发展为未来的能源一代开辟了一条道路。研究的目的是在保护自然环境的同时,找出适合于不损害环境的不同发电技术。随着地球气温的日益升高,能源的日益枯竭,全球气候变暖,发展一些绿色技术方法来拯救生命和财产是不可避免的。绿色能源覆盖着环境保护,是经济、社会和环境领域的中心。由石油、煤炭和天然气等不同来源生产的燃料正试图成为经济发展的有效引擎,但与此同时,它们对环境有害,也损害健康,与全球能源需求相冲突。从农业到房屋建筑,每一个利用能源的部门都在应用绿色技术,以实现可持续发展而不损害环境。随着工业增长的兴起,社会的发展导致温室气体排放到大气中,使水不适合消费,也不适合呼吸空气。因此,绿色技术是通向未来替代技术的合适途径。
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引用次数: 1
A Review on Adansonia digitata: An African Tree 一种非洲乔木——Adansonia digitata综述
Pub Date : 2022-05-03 DOI: 10.52711/2349-2988.2022.00021
Ganesh R Bharskar
Adansonia digitata native to Africa, also found in India belongs to Bombacaceae family. Every part of the plant should be edible. Baobab is older than 4000 years. Adansonia digitata consists of various phytochemical constituents identified from various parts which are vitamin-C, steroids, flavonoids, epicatechin, campesterol, amino acid etc. It is used in the treatment of bronchial asthma, dermatitis, sickle cell anemia, diuretic, anti-diabetic, diarrhoea, dysentery, laxative, hiccough in children, anti-oxidant, anti-inflammatory, antidote for poison, anti-trypanosome uses. The present article summarizes the review of phytochemical, pharmacological activity.
adansononia digitata原产于非洲,也发现于印度,属于Bombacaceae科。植物的每一部分都应该是可食用的。猴面包树有4000多年的历史了。Adansonia digitata由多种植物化学成分组成,包括维生素c、类固醇、黄酮类化合物、表儿茶素、油菜甾醇、氨基酸等。用于治疗支气管哮喘、皮炎、镰状细胞性贫血、利尿剂、抗糖尿病、腹泻、痢疾、通便剂、小儿呃逆、抗氧化、抗炎、解毒、抗锥虫等用途。本文综述了植物化学、药理活性方面的研究进展。
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引用次数: 2
Deeper Insights into role of Green Technology for Pollution Free Environment: An updated Review 绿色技术在无公害环境中的作用:最新综述
Pub Date : 2022-05-03 DOI: 10.52711/2349-2988.2022.00016
Abinash Satapathy, Kunal Chandrakar, S. Kaushik, T. Satapathy
India is the second largest country in the world based on the population that faces many challenges for various environmental issues such as water and air pollution etc. As per the survey by World Bank experts this issues become more exacerbated between 1947 and 1995. Within last decade India has devoted towards putting much efforts to resolve these environmental issues and improving environmental qualities. The major possible issues those contributes to various environmental issues include population growth, deforestation, establishment of industries for growth of economy, burning of fuel, degradation of agricultural lands, drainage of consumer waste into water resources such as rivers, depletion of natural resources such as water, mineral, rocks etc. Another major factor that contributes largely for environmental pollution includes solid waste pollution. As per the data available elsewhere there are more than hundred million tons of solid wastes generated by various cities in India in every year. Now-a-days it has been observed that the tourist places of India are also facing such issues. Green technology is an environment friendly technology which has developed and used to protect the environment and conserves natural resources. This technology is intended to mitigate or reverse the effects of human activity on the environment. Green technology generally uses innovative ideas and methods to create environment friendly products. Green nano-technology that uses green engineering and green chemistry is one of the emerging fields in science and technology. In the matter of environmental pollution and the disposal of waste, Green technology answers to that as well. Among all the possible areas where the creations and growth are possible that include; eco- friendly textiles, biodegradable papers and containers, green energy, green building, organic agriculture, and manufacturing of similar products and materials to support green business. Green technology covers a broad area of production and consumption technologies. The 7R’s of green technology also includes replace, reduce, reliable, repair, reuse, recycle and resources. The green technologies involve the use of environmental technologies for assessment of pollution prevention and control, remediation and restoration. A prevention technology helps to avoid the production of environmentally hazardous substances to minimize damage to the environment.
印度是世界上人口第二大的国家,面临着各种环境问题的挑战,如水和空气污染等。根据世界银行专家的调查,这个问题在1947年至1995年间变得更加严重。在过去的十年里,印度一直致力于为解决这些环境问题和改善环境质量做出巨大努力。造成各种环境问题的主要可能问题包括人口增长、森林砍伐、为经济增长而建立的工业、燃料燃烧、农业用地退化、消费废物排入河流等水资源、水、矿物、岩石等自然资源的枯竭。造成环境污染的另一个主要因素是固体废物污染。根据其他地方的数据,印度各城市每年产生的固体废物超过1亿吨。如今,人们观察到印度的旅游景点也面临着这样的问题。绿色技术是为了保护环境和节约自然资源而发展和使用的一种环境友好型技术。这项技术旨在减轻或扭转人类活动对环境的影响。绿色科技一般采用创新的理念和方法来创造对环境友好的产品。绿色纳米技术是集绿色工程和绿色化学于一体的新兴科技领域之一。在环境污染和废物处理问题上,绿色技术也能解决这个问题。在所有可能创造和成长的领域中,包括;环保纺织品、生物可降解纸和容器、绿色能源、绿色建筑、有机农业以及类似产品和材料的制造,以支持绿色商业。绿色技术涵盖了生产和消费技术的广泛领域。绿色科技的7R还包括替换(replace)、减少(reduce)、可靠(reliable)、维修(repair)、再利用(reuse)、回收(recycle)和资源(resource)。绿色技术涉及利用环境技术评价污染的预防和控制、补救和恢复。预防技术有助于避免生产对环境有害的物质,以尽量减少对环境的损害。
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引用次数: 1
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