Respiratory investigation最新文献

英文中文

The risk of recurrence in pathological stage II-IIIA non-small cell lung cancer without lymph node metastasis 病理II-IIIA期无淋巴结转移的非小细胞肺癌复发风险分析

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1016/j.resinv.2025.101349

Ryusuke Sumiya , Takeshi Matsunaga , Yukio Watanabe , Hisashi Tomita , Takuo Hayashi , Mariko Fukui , Aritoshi Hattori , Kazuya Takamochi , Kenji Suzuki

Background

According to LACE analysis, patients diagnosed with p-Stage II-III non-small cell lung cancer (NSCLC) are usually indicated for adjuvant chemotherapy, including platinum doublets. We aimed to identify the risk of recurrence in NSCLC patients without lymph node metastasis.

Methods

Between 2009 and 2018, 187 patients underwent lung resection of one or more lobes and mediastinal lymph node dissection for p-Stage II-IIIA NSCLC. Among them, 112 were included after excluding those with a history of lung cancer, perioperative chemotherapy. Staging was based on 8th Edition of IASLC staging system. Multivariate analysis was performed to identify important prognostic factors for oncologic outcomes.

Results

Among the evaluated patients, 84 were male, and with a median age of 67 years. Seventy-one (51.4 %) patients were diagnosed with adenocarcinoma. The cancer stages were stage IIA in 34 patients, stage IIB in 57 patients, and stage IIIA in 21 patients. Multivariate analysis of disease-free survival revealed that vascular invasion (HR, 2.481; 95 %CI, 1.411–4.362, P < 0.01) and pathological T factor (HR, 1.819; 95 %CI, 1.226–2.699, P < 0.01) were the independent risk factors. Gray's test for equality of cumulative incidence functions revealed that the five-year cumulative incidence of recurrence was particularly high in patients with vascular invasion compared to that in patients without vascular invasion (21.5 % vs. 37.5 %, P = 0.03).

Conclusions

Vascular invasion is a significant predictor of lung cancer recurrence in patients with p-Stage II-IIIA NSCLC without lymph node metastasis. The patients without vascular invasion in this cohort had a favorable prognosis, with a 5-year recurrence rate of 21.5 %.

根据LACE分析，诊断为p期II-III期非小细胞肺癌（NSCLC）的患者通常需要辅助化疗，包括铂双药。我们的目的是确定无淋巴结转移的非小细胞肺癌患者的复发风险。方法2009年至2018年间，187例p期II-IIIA期NSCLC患者接受了单叶或多叶肺切除术和纵隔淋巴结清扫术。其中剔除肺癌、围手术期化疗史的纳入112例。分期依据第8版IASLC分期体系。进行多变量分析以确定影响肿瘤预后的重要预后因素。结果84例男性，中位年龄67岁。71例（51.4%）患者被诊断为腺癌。癌症分期为IIA期34例，IIB期57例，IIIA期21例。多因素无病生存分析显示，血管侵犯（HR, 2.481; 95% CI, 1.411 ~ 4.362, P < 0.01）和病理性T因子（HR, 1.819; 95% CI, 1.226 ~ 2.699, P < 0.01）是独立危险因素。累积发生率函数的格雷检验显示，血管侵犯患者的5年累积复发率比无血管侵犯患者特别高（21.5%比37.5%,P = 0.03）。结论血管侵犯是无淋巴结转移的p期II-IIIA期非小细胞肺癌复发的重要预测因子。该队列中无血管侵犯的患者预后良好，5年复发率为21.5%。

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引用次数: 0

Successful tracheostomy tube removal following airway clearance using intrapulmonary percussive ventilation treatment after bilateral lung transplantation in a patient with idiopathic pleuroparenchymal fibroelastosis 特发性胸膜实质纤维弹性增生患者双侧肺移植术后使用肺内冲击通气清除气道后气管造口成功拔管一例

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-11-25 DOI: 10.1016/j.resinv.2025.101336

Satoshi Hamada , Tomohiko Yamaguchi , Yohei Oshima , Yoshihiro Nishino , Satona Tanaka , Daisuke Nakajima , Toyohiro Hirai

Sputum management is a critical and potentially lethal issue in patients following lung transplantation. Here, we describe a patient with idiopathic pleuroparenchymal fibroelastosis who underwent tracheotomy after deceased donor bilateral lung transplantation, in whom we were unable to remove the tracheostomy tube due to difficulty in sputum evacuation. The tube was successfully removed following the subsequent initiation of intrapulmonary percussive ventilation (IPV) treatment combined with pulmonary rehabilitation. IPV has been widely used for several decades for treating pulmonary conditions, including chronic obstructive pulmonary disease, cystic fibrosis, and bronchiectasis. However, it should also be considered for airway clearance after lung transplantation.

痰液管理是肺移植术后患者的一个关键和潜在的致命问题。在这里，我们描述了一个特发性胸膜实质纤维弹性增生患者，他在死亡的双侧供体肺移植后接受了气管切开术，由于痰液难以排出，我们无法取出气管切开术管。在随后开始肺内冲击通气（IPV）治疗并结合肺部康复后，成功拔出了管子。几十年来，IPV被广泛用于治疗肺部疾病，包括慢性阻塞性肺疾病、囊性纤维化和支气管扩张。然而，肺移植后气道清除也应考虑。

引用次数: 0

Impact of pneumothorax on clinical course of patients with amyotrophic lateral sclerosis on long-term ventilation 气胸对肌萎缩侧索硬化症长期通气患者临床病程的影响

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1016/j.resinv.2025.11.008

Nobuhiro Okagaki , Tomomasa Tsuboi , Yuichi Chihara , Kensuke Sumi , Hiroki Takeuchi , Kenji Yamamoto , Takashi Hajiro , Atsuo Sato

Background

Numerous clinical studies have shown that long-term positive pressure ventilation (PPV) improves quality of life and prognosis in patients with amyotrophic lateral sclerosis (ALS). Pneumothorax is an important complication of PPV; however, few studies investigated pneumothorax in patients with ALS on long-term PPV.

Methods

This retrospective longitudinal cohort study included 85 patients with ALS treated from 2013 to 2024. We collected information from medical records on ALS and pneumothorax treatment, blood laboratory data, radiology data, equipment data, and mortality. Subsequently, we compared clinical parameters and prognosis between the pneumothorax and non-pneumothorax groups.

Results

Of the 85 patients, 61 underwent long-term PPV. Nine patients developed pneumothorax following the initiation of long-term PPV. In contrast, 24 patients without long-term PPV did not experience pneumothorax. Among patients who received tracheostomy PPV as a maximum respiratory management, the pneumothorax group tended to have a poorer prognosis from ALS onset than the non-pneumothorax group. Moreover, the pneumothorax group had higher inspiratory positive airway pressure and support pressure of ventilator settings than the non-pneumothorax group. Among the nine pneumothorax cases, there were no deaths directly related to the complication, two patients who developed pneumothorax during non-invasive PPV transitioned to tracheostomy PPV as a result of the complication.

Conclusions

Pneumothorax should be recognized as a serious complication that can occur in patients with ALS on PPV. Higher inspiratory positive airway pressure and support pressure settings on long-term PPV may be significant risk factors for pneumothorax.

大量临床研究表明，长期正压通气（PPV）可改善肌萎缩侧索硬化症（ALS）患者的生活质量和预后。气胸是PPV的重要并发症；然而，很少有研究调查长期PPV对ALS患者气胸的影响。方法回顾性纵向队列研究纳入2013 - 2024年接受治疗的85例ALS患者。我们收集了有关ALS和气胸治疗的医疗记录、血液实验室数据、放射学数据、设备数据和死亡率的信息。随后，我们比较了气胸组和非气胸组的临床参数和预后。结果85例患者中，61例接受了长期PPV治疗。9例患者在开始长期PPV治疗后发生气胸。相比之下，没有长期PPV的24例患者没有发生气胸。在接受气管切开术PPV作为最大呼吸管理的患者中，气胸组在ALS发病后的预后往往比非气胸组差。气胸组吸气气道正压和呼吸机支持压力均高于非气胸组。在9例气胸病例中，没有与并发症直接相关的死亡，2例在无创PPV期间发生气胸的患者由于并发症而过渡到气管造口PPV。结论肺气胸是肌萎缩侧索硬化症患者在PPV治疗过程中可能发生的严重并发症。长期PPV患者较高的吸气气道正压和支持压力设置可能是气胸的重要危险因素。

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引用次数: 0

Effect of large-volume intrapleural saline lavage for empyema: a single-center, prospective cohort study 大容量胸腔内盐水灌洗治疗脓胸的效果：一项单中心前瞻性队列研究。

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1016/j.resinv.2025.101354

Masanori Kawataki , Akihiro Ito , Hiromasa Tachibana , Yosuke Nakanishi , Shotaro Ide , Akitsugu Furumoto , Hiroshi Mukae , Tadashi Ishida

Background

Intrapleural fibrinolytic therapy has emerged as a preferred treatment for empyema, helping to reduce the need for surgery and shorten hospital stays. However, fibrinolytic drugs may not be available in some regions due to distribution challenges. In such situations, intrapleural saline lavage can serve as an effective alternative treatment option. Evidence supporting the use of intrapleural saline lavage remains limited, primarily because previous studies have used low lavage volumes.

Methods

We aimed to compare hospital stays, 30-day mortality rates, rates of referral to surgery, length of drainage, and adverse events between two groups of empyema patients: one receiving pleural lavage with urokinase administration; and the other receiving pleural lavage using 500 mL of saline. This was a single-center, prospective cohort study that analyzed patients contracting empyema with positive culture of pleural fluids admitted to our hospital between March 2021 and March 2023.

Results

The 33 patients comprised 18 in the urokinase group and 15 in the saline group. No significant differences were seen in 30-day mortality rate (p = 0.08) or referral for surgery (p = 0.618). Although the overall duration of hospital stay appeared comparable between the groups, competing risk analysis accounting for death as a competing event demonstrated a significant difference in time to discharge (p = 0.023), with a longer hospital stay observed in the saline group. Non-inferiority analysis showed significant differences between groups in additional drainage tubes.

Conclusions

No significant difference in surgical referrals or mortality was evident between intrapleural saline lavage and urokinase therapy. However, saline lavage in acute empyema may be less effective and result in longer hospital stays, even with larger volumes.

Trial registration

This study was performed using data from a prospective epidemiological study for patients with pneumonia (UMIN000004353).

背景：胸膜内溶栓治疗已成为治疗脓胸的首选方法，有助于减少手术需求并缩短住院时间。然而，由于分销方面的挑战，一些地区可能无法获得纤溶药物。在这种情况下，胸腔内盐水灌洗可作为一种有效的替代治疗选择。支持使用胸腔内盐水灌洗的证据仍然有限，主要是因为以前的研究使用了低灌洗量。方法：我们的目的是比较两组脓胸患者的住院时间、30天死亡率、转诊手术率、引流时间和不良事件：一组接受胸膜灌洗并给予尿激酶；另一组接受500ml生理盐水胸腔灌洗。这是一项单中心、前瞻性队列研究，分析了2021年3月至2023年3月期间在我院住院的胸膜液培养阳性的脓胸患者。结果：尿激酶组18例，生理盐水组15例。30天死亡率（p = 0.08）和转诊手术（p = 0.618）无显著差异。虽然两组之间的总住院时间似乎具有可比性，但将死亡作为竞争事件考虑在内的竞争风险分析显示，在出院时间上存在显著差异（p = 0.023），生理盐水组的住院时间更长。非劣效性分析显示两组间增加引流管数量有显著差异。结论：胸膜内盐水灌洗与尿激酶治疗在手术转诊和死亡率方面无明显差异。然而，急性脓胸的生理盐水灌洗可能效果较差，甚至导致更长的住院时间，即使是更大的容量。试验注册：本研究使用来自肺炎患者前瞻性流行病学研究（UMIN000004353）的数据进行。

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引用次数: 0

High-intensity inspiratory muscle training and diaphragm thickness in severe COPD: a prospective pilot study 重度COPD患者的高强度吸气肌训练和膈肌厚度：一项前瞻性先导研究

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1016/j.resinv.2025.101348

Daisuke Minamishima , Yuko Asato , Kazuhiro Tsuji , Rin Anamizu , Nami Hasegawa , Daisuke Shiihara

High-intensity inspiratory muscle training (IMT) has been reported to increase diaphragm thickness in healthy adults, but evidence in severe chronic obstructive pulmonary disease (COPD) remains scarce. This prospective pilot study evaluated the effects of high-intensity IMT on diaphragm thickness and functional outcomes in nine patients with severe COPD who had completed standard respiratory rehabilitation. Participants performed 30 breaths per day at 60 % of maximum inspiratory pressure for 12 weeks. Diaphragm thickness at maximum inspiration increased from 4.7 to 5.6 mm, maximum inspiratory pressure from 57.1 to 68.1 cmH₂O, 6-min walk distance from 318 to 366 m, and COPD Assessment Test scores from 19 to 12, both exceeding the minimal clinically important difference thresholds (all p < 0.01). These findings suggest that high-intensity IMT may be a feasible and beneficial adjunct for improving inspiratory function and symptoms in patients with severe COPD.

据报道，高强度的吸气肌训练（IMT）可以增加健康成人的横膈膜厚度，但在严重慢性阻塞性肺疾病（COPD）中的证据仍然很少。这项前瞻性试点研究评估了高强度IMT对9例重度COPD患者膈膜厚度和功能结局的影响，这些患者已完成标准呼吸康复。参与者每天以最大吸气压力的60%进行30次呼吸，持续12周。最大吸气时膈膜厚度从4.7增加到5.6 mm，最大吸气压力从57.1增加到68.1 cmH2O， 6分钟步行距离从318增加到366 m， COPD评估测试分数从19增加到12，均超过最小临床重要差异阈值（均p <； 0.01）。这些发现表明，高强度IMT可能是一种可行且有益的辅助手段，可改善严重COPD患者的吸气功能和症状。

引用次数: 0

BRAF V600E-mutant squamous cell carcinoma of the lung in patients with a history of papillary thyroid carcinoma: A three-case series 有甲状腺乳头状癌病史的患者的BRAF v600e突变型肺鳞状细胞癌：三例系列

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.resinv.2025.101344

Naozumi Hashimoto , Ryoma Moriya , Ken Akao , Hisashi Kako , Yasuhiro Goto , Tomohide Souma , Yuko Oya , Yuka Kondo , Tetsuya Tsukamoto , Sumito Isogai , Masashi Kondo , Kazuyoshi Imaizumi

There is limited data on BRAF V600E-mutant squamous cell carcinoma (SCC). We report three cases of SCC of the lung with a history of resected papillary thyroid carcinoma (PTC), showing p40 positivity, TTF-1 negativity, and PAX8 expression. While treated as lung SCC, metastatic thyroid carcinoma was unconfirmed due to absence of PTC recurrence, clinicopathologic features consistent with primary lung origin, and unavailable archival PTC pathology. BRAF inhibitors yielded only transient responses, and outcomes were poor. These cases underscore the diagnostic and therapeutic value of multigene testing in SCC, highlighting the need to integrate detailed clinical history into precision oncology strategies.

关于BRAF v600e突变型鳞状细胞癌（SCC）的数据有限。我们报告3例肺SCC伴有切除的甲状腺乳头状癌（PTC）病史，显示p40阳性，TTF-1阴性，PAX8表达。在作为肺SCC治疗时，转移性甲状腺癌由于PTC未复发，临床病理特征与原发性肺起源一致，以及没有PTC病理档案而未得到证实。BRAF抑制剂只能产生短暂的反应，而且结果很差。这些病例强调了多基因检测在SCC中的诊断和治疗价值，强调了将详细的临床病史整合到精确的肿瘤学策略中的必要性。

引用次数: 0

Bronchoscopic lung insufflation for post-transplant lobar atelectasis: Efficacy and a rare complication of cerebral gas embolism 支气管镜下肺充气治疗移植后肺大叶不张：疗效和脑气栓塞的罕见并发症

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1016/j.resinv.2025.101339

Yojiro Yutaka , Akira Matsumoto , Ichiro Sakanoue , Hidenao Kayawake , Satona Tanaka , Daisuke Nakajima , Hiroshi Date

Bronchoscopic lung insufflation (BLI) allows re-expansion of collapsed lung lobes after transplantation. Among 254 transplant cases at our center, two patients underwent BLI for lobar atelectasis. Case 1 had recurrent right middle-lobe collapse after initial recovery, and BLI under conscious sedation led to durable re-expansion without complications. Case 2 underwent BLI for right upper-lobe atelectasis but developed transient neurological deficits due to presumed cerebral gas embolism, despite initial re-expansion. Full recovery was achieved with supportive care. These cases highlight BLI as an effective treatment for post-transplant atelectasis, although rare but serious complications require careful monitoring.

支气管镜肺充气（BLI）允许移植后塌陷的肺叶重新扩张。在我们中心的254例移植病例中，有2例患者因肺叶不张而行BLI。病例1在初次恢复后复发右中叶塌陷，清醒镇静下的BLI导致持续的再扩张，无并发症。病例2因右上肺叶不张接受了BLI治疗，尽管最初再次扩张，但由于假定的脑气栓塞而出现了一过性神经功能障碍。在支持性护理下完全康复。这些病例强调BLI是移植后肺不张的有效治疗方法，虽然罕见但严重的并发症需要仔细监测。

引用次数: 0

High diagnostic yield and treatment impact of bronchoscopy in elderly lung cancer patients (≥ 80 years): A single-center retrospective study 老年肺癌患者（≥80岁）支气管镜检查的高诊断率和治疗效果：一项单中心回顾性研究

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.resinv.2025.101335

Shingo Maeda , Takuma Ina , Atsuhiko Ota , Masaaki Matsunaga , Tomoya Horiguchi , Aki Ikeda , Ryoma Moriya , Takaya Sato , Chiaki Sawada , Yuko Oya , Shotaro Okachi , Yasuhiro Goto , Sumito Isogai , Naozumi Hashimoto , Masashi Kondo , Kazuyoshi Imaizumi

Background

Although bronchoscopic biopsy serves as a cornerstone for diagnosing lung cancer in elderly patients, whether this procedure leads to clinically relevant outcomes is still unclear. This study aimed to clarify the clinical significance of diagnostic bronchoscopy in lung cancer patients aged ≥80 years.

Methods

We retrospectively analyzed 803 patients diagnosed with lung cancer who underwent bronchoscopy at our hospital from April 2015 to March 2019. Those aged ≥80 years and <80 years were classified as the elderly group (n = 154) and young group (n = 649), respectively.

Results

The diagnostic yield of bronchoscopy in the elderly and young groups was 92.9 % and 83.5 %, respectively; complication rates were 9.6 % and 7.2 %. Approximately 89 % of the patients in the elderly group received specific lung cancer treatment. The 5-year survival rates for elderly and young patients who underwent surgery were 74.5 % and 78.2 %, respectively. In the elderly group, 11 % of the patients chose best supportive care (BSC) only, compared with 2 % in the young group. Notably, patients with non-diagnostic bronchoscopic results selected BSC more frequently in the elderly versus young groups (30.4 % versus 0 %, respectively).

Conclusions

Bronchoscopy in elderly patients with lung cancer demonstrated a high diagnostic yield and an acceptable safety profile, enabling specific treatments in the majority of cases. These findings support the clinical usefulness of bronchoscopy in guiding treatment decisions for elderly patients. However, non-diagnostic results were associated with a higher likelihood of BCS, highlighting the importance of achieving a definitive diagnosis in this population.

背景：尽管支气管镜活检是诊断老年患者肺癌的基础，但该手术是否会导致临床相关的结果尚不清楚。本研究旨在阐明≥80岁肺癌患者诊断性支气管镜检查的临床意义。方法：回顾性分析2015年4月至2019年3月在我院行支气管镜检查的803例肺癌患者。≥80岁及结果：老年组支气管镜诊断率为92.9%，青年组为83.5%；并发症发生率分别为9.6%和7.2%。大约89%的老年组患者接受了特定的肺癌治疗。老年和年轻患者手术后的5年生存率分别为74.5%和78.2%。在老年组中，11%的患者只选择了最佳支持治疗（BSC），而在年轻组中，这一比例为2%。值得注意的是，非诊断性支气管镜检查结果的患者在老年人中比年轻人更频繁地选择BSC（分别为30.4%和0%）。结论：支气管镜检查在老年肺癌患者中具有较高的诊断率和可接受的安全性，可在大多数病例中进行特异性治疗。这些发现支持支气管镜检查在指导老年患者治疗决策中的临床应用。然而，非诊断性结果与BCS的可能性较高相关，强调了在该人群中获得明确诊断的重要性。

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引用次数: 0

Impact of bendopnea on indicators of pulmonary hypertension, health-related quality of life, and pulmonary function in patients with chronic obstructive pulmonary disease 弯曲通气对慢性阻塞性肺疾病患者肺动脉高压、健康相关生活质量和肺功能指标的影响

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1016/j.resinv.2025.101346

Toshitaka Shomura , Yosuke Wada , Norihiko Goto , Yusuke Suzuki , Yoshiaki Kitaguchi , Atsuhito Ushiki , Taku Osawa , Masanori Yasuo , Masayuki Hanaoka

Background

Bendopnea is a recognized symptom in patients with systolic heart failure; however, its clinical relevance in those with chronic obstructive pulmonary disease (COPD) has not been fully elucidated. This study aimed to evaluate the potential impact of bendopnea on the coexistence of comorbid pulmonary hypertension (PH), various metrics of health-related quality of life (HRQoL), chest CT findings, and respiratory function in a cohort of patients with COPD.

Methods

This retrospective study analyzed the medical records of 133 patients with COPD at Shinshu University Hospital (Matsumoto, Japan). Bendopnea was defined as a positive response to a bendopnea-related question based on the corresponding item in the St. George's Respiratory Questionnaire (SGRQ). Pulmonary artery and descending aorta diameters were measured on CT scans. To assess emphysema severity, the percentage of low-attenuation volume (LAV%) was calculated from the same CT scans using specialized image analysis software. Respiratory impedance was evaluated using oscillometry. Indicators of PH, emphysema severity, HRQoL, and pulmonary function were compared between patients who reported bendopnea and those who did not.

Results

Compared to those without bendopnea, patients with the symptom had a significantly higher pulmonary artery-to-descending aorta diameter ratio and LAV%, as well as markedly poorer HRQoL. Regarding oscillometry parameters, reactance at 5 Hz (X5) was significantly decreased in the bendopnea group, while elevated resonant frequency (Fres) and area under the low-frequency reactance curve (ALX) values were also observed.

Conclusions

Bendopnea may serve as a clinical indicator of a more advanced disease state in COPD.

背景：腹底通气是收缩期心力衰竭患者公认的症状；然而，其在慢性阻塞性肺疾病（COPD）患者中的临床意义尚未完全阐明。本研究旨在评估benendopnea对COPD患者共病肺动脉高压（PH）共存、各种健康相关生活质量指标（HRQoL）、胸部CT表现和呼吸功能的潜在影响。方法：本回顾性研究分析了日本松本信州大学医院133例COPD患者的病历。弯曲呼吸被定义为对基于圣乔治呼吸问卷（SGRQ）中相应项目的弯曲呼吸相关问题的积极回应。在CT上测量肺动脉和降主动脉的直径。为了评估肺气肿的严重程度，使用专门的图像分析软件计算相同CT扫描的低衰减体积百分比（LAV%）。用振荡法测定呼吸阻抗。比较报告弯曲通气的患者和没有报告弯曲通气的患者的PH、肺气肿严重程度、HRQoL和肺功能指标。结果：有此症状的患者肺动脉降主动脉径比和LAV%明显高于无此症状的患者，HRQoL明显低于无此症状的患者。在振荡参数方面，benendopnea组5 Hz电抗（X5）明显降低，同时共振频率（Fres）和低频电抗曲线下面积（ALX）值也有所升高。结论：弯曲通气可作为慢性阻塞性肺病更晚期疾病状态的临床指标。

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引用次数: 0

Corrigendum to “Factors associated with pulmonary function decline in patients with rheumatoid arthritis-associated interstitial lung disease” [Respir. Investig. Volume 63, Issue 5, Pages 857–865] 《类风湿关节炎相关间质性肺病患者肺功能下降相关因素》的勘误。Investig。第63卷，第5期，857-865页]。

IF 2 Q2 RESPIRATORY SYSTEM

Respiratory investigation

Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1016/j.resinv.2025.101345

Takako Kawaguchi , Masahiro Tahara , Kei Yamasaki , Natsumi Tani , Yurie Kanda-Satoh , Takatoshi Aoki , Yoshiya Tanaka , Kazuhiro Yatera

引用次数: 0

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