Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00029
Sanajy S. Patel, Gayatri C. Patel, Chirag S. Patel
The aim of the present study was to formulate stable silver sulfadiazine (SSD) liposomal gel suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD liposomes were formulated using thin film hydration technique. A 23 factorial design was utilized to study the effect of the molar ratio of lipid: cholesterol (X1), drug concentration (X2) and hydration volume on Encapsulation efficiency (EE%) and vesicle size. Selected batch of liposome was incorporated in to PVPK-30 and HPMCK4M gel base to prepare the liposomal gel formulation, which was evaluated for in-vitro release and in-vivo study. It was evident from the derived polynomial equations and constructed contour plot, an increase in the level of X1 and a decrease in the X2 lead to an increase in EE% and increase in vesicle size. Each of the prepared liposomal gel formulation significantly improved (P<0.05) cumulative amount of drug release owing to the influence of the gel matrix. Among the liposomal gel formulation, L6 (prepared at high level of X1 and low level of X2) showed best release may be due to efficient hydration of the film and more total amount of drug entrapped. In-vivo studies revealed that a liposomal gel containing 0.5% SSD was more effective in wound healing compared to marketed cream.
{"title":"Development of Liposomal Encapsulated Silver Sulfadiazine Gel for Burn Therapy","authors":"Sanajy S. Patel, Gayatri C. Patel, Chirag S. Patel","doi":"10.52711/0975-4377.2023.00029","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00029","url":null,"abstract":"The aim of the present study was to formulate stable silver sulfadiazine (SSD) liposomal gel suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD liposomes were formulated using thin film hydration technique. A 23 factorial design was utilized to study the effect of the molar ratio of lipid: cholesterol (X1), drug concentration (X2) and hydration volume on Encapsulation efficiency (EE%) and vesicle size. Selected batch of liposome was incorporated in to PVPK-30 and HPMCK4M gel base to prepare the liposomal gel formulation, which was evaluated for in-vitro release and in-vivo study. It was evident from the derived polynomial equations and constructed contour plot, an increase in the level of X1 and a decrease in the X2 lead to an increase in EE% and increase in vesicle size. Each of the prepared liposomal gel formulation significantly improved (P<0.05) cumulative amount of drug release owing to the influence of the gel matrix. Among the liposomal gel formulation, L6 (prepared at high level of X1 and low level of X2) showed best release may be due to efficient hydration of the film and more total amount of drug entrapped. In-vivo studies revealed that a liposomal gel containing 0.5% SSD was more effective in wound healing compared to marketed cream.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present study was to evaluate the effects of Tridax procumbens extract on calcium oxalate and calcium phosphate by in vitro methods. The leaves of Tridax procumbens were sequentially extracted by using hot maceration method, with solvent such as ethanol, water and hydroalcoholic solution in various concentrations. The obtained extract was subjected for phytochemical screening and the test for alkaloid, flavonoid, saponin, phenol, triterpenoid saponin. For the in vitro study, experimentally calcium phosphate and calcium oxalate stones were prepared and compared with standard drug. Cystone used as a standard drug. Tridax procumbens is rich in phytochemicals such as alkaloids, saponin, glycoside, kamferol, and flavonoids and has a substantial capacity to dissolve calcium phosphate and calcium oxalate. These flavonoids inhibit calcium Phosphate and calcium oxalate deposits from forming in the renal tubules. The leaf extract contains anti-urolithiasis therapy and preventative capabilities and lowers the size of stones. In addition to diuretic and antiurolithic, antidiabetic, anticancer, anti-ulcer, anti-microbial, and wound healing activities, Tridax procumbens flower extract includes phenolic chemicals, tannin, and titerpenes. The main goal of the study is to find out how the Tridax procumbens herb, especially its leaves, can prevent and treat health problems like renal stones, which are becoming more common in younger people because they don't exercise and eat poorly. The ability of the extract to get small particles out of the kidney and out of the urinary tract reduces the chance that they will get stuck in the urinary tract and form stones.
{"title":"In-vitro Assessment of Antiurolithiatic activity of Tridax procumbens Flower Extracts","authors":"Wajid Ahmad, Rihan Jawed, Yashdeep Thakur, Reena Thakur","doi":"10.52711/0975-4377.2023.00026","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00026","url":null,"abstract":"The aim of the present study was to evaluate the effects of Tridax procumbens extract on calcium oxalate and calcium phosphate by in vitro methods. The leaves of Tridax procumbens were sequentially extracted by using hot maceration method, with solvent such as ethanol, water and hydroalcoholic solution in various concentrations. The obtained extract was subjected for phytochemical screening and the test for alkaloid, flavonoid, saponin, phenol, triterpenoid saponin. For the in vitro study, experimentally calcium phosphate and calcium oxalate stones were prepared and compared with standard drug. Cystone used as a standard drug. Tridax procumbens is rich in phytochemicals such as alkaloids, saponin, glycoside, kamferol, and flavonoids and has a substantial capacity to dissolve calcium phosphate and calcium oxalate. These flavonoids inhibit calcium Phosphate and calcium oxalate deposits from forming in the renal tubules. The leaf extract contains anti-urolithiasis therapy and preventative capabilities and lowers the size of stones. In addition to diuretic and antiurolithic, antidiabetic, anticancer, anti-ulcer, anti-microbial, and wound healing activities, Tridax procumbens flower extract includes phenolic chemicals, tannin, and titerpenes. The main goal of the study is to find out how the Tridax procumbens herb, especially its leaves, can prevent and treat health problems like renal stones, which are becoming more common in younger people because they don't exercise and eat poorly. The ability of the extract to get small particles out of the kidney and out of the urinary tract reduces the chance that they will get stuck in the urinary tract and form stones.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00030
S. Janet Beula, T. Ramamohan Reddy, R. Suthakaran, M. Viswaja
A simple and selective LC method is described for the determination of Lafutidine in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer (KH2PO4) pH4.0: Acetonitrile (30:70v/v/v), with detection of 299nm. Linearity was observed in the range 60-140µg/ml for Lafutidine (r2 =0.999) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. From the above experimental results and parameters it was concluded that, this newly developed method for the simultaneous estimation of Lafutidine was found to be simple, precise, accurate and high resolution and shorter retention time makes this method more acceptable and cost effective and it can be effectively applied for routine analysis in research institutions, quality control department in meant in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies.
{"title":"RP-HPLC Method Development and Validation for the Estimation of Lafutidine using Bulk and Pharmaceutical Dosage Forms","authors":"S. Janet Beula, T. Ramamohan Reddy, R. Suthakaran, M. Viswaja","doi":"10.52711/0975-4377.2023.00030","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00030","url":null,"abstract":"A simple and selective LC method is described for the determination of Lafutidine in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer (KH2PO4) pH4.0: Acetonitrile (30:70v/v/v), with detection of 299nm. Linearity was observed in the range 60-140µg/ml for Lafutidine (r2 =0.999) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. From the above experimental results and parameters it was concluded that, this newly developed method for the simultaneous estimation of Lafutidine was found to be simple, precise, accurate and high resolution and shorter retention time makes this method more acceptable and cost effective and it can be effectively applied for routine analysis in research institutions, quality control department in meant in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00034
Arjun Singh
Recent studies shown that the data of clinical, experimental and epidemiological studies indicates that dietary phytoestrogens, flavonoids and polyphenolic compounds have shown most potent activities for prevention in CVDs. The major class of compounds found in phytoestrogen. These phytoestrogens are sub-classified into coumestans, prenylflavonoids and isoflavones. These class having the most active class in estrogenic effects, polyphenols (also known as polyhydroxyphenols includes tannic acid, ellagitannin. These studies also indicate that dietary supplements and food nutrients have profound cardioprotective effects in the primary as well as secondary coronary heart disease and hence they are considered as cardiovascular friendly natural products. The mechanism of cardioprotection produced by dietary nutritional supplements such as phytoestrogens (soy and soy protein), flavonoids (citrus fruits, pulses, red wine, tea and cocoa), olive oil, omega-3 fatty acids (fish oil and fish-based products), lycopene (tomato and tomato-based products), resveratrol (grapes and red wine), coffee, and soy in the prevention and treatment of cardiovascular disorders have been discussed in the following review (in parenthesis) with the emphasis of epidemiological and clinical studies. Based on the intriguing results of various studies, prophylactic and therapeutic potential of cardiovascular friendly natural products have been suggested.
{"title":"An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism","authors":"Arjun Singh","doi":"10.52711/0975-4377.2023.00034","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00034","url":null,"abstract":"Recent studies shown that the data of clinical, experimental and epidemiological studies indicates that dietary phytoestrogens, flavonoids and polyphenolic compounds have shown most potent activities for prevention in CVDs. The major class of compounds found in phytoestrogen. These phytoestrogens are sub-classified into coumestans, prenylflavonoids and isoflavones. These class having the most active class in estrogenic effects, polyphenols (also known as polyhydroxyphenols includes tannic acid, ellagitannin. These studies also indicate that dietary supplements and food nutrients have profound cardioprotective effects in the primary as well as secondary coronary heart disease and hence they are considered as cardiovascular friendly natural products. The mechanism of cardioprotection produced by dietary nutritional supplements such as phytoestrogens (soy and soy protein), flavonoids (citrus fruits, pulses, red wine, tea and cocoa), olive oil, omega-3 fatty acids (fish oil and fish-based products), lycopene (tomato and tomato-based products), resveratrol (grapes and red wine), coffee, and soy in the prevention and treatment of cardiovascular disorders have been discussed in the following review (in parenthesis) with the emphasis of epidemiological and clinical studies. Based on the intriguing results of various studies, prophylactic and therapeutic potential of cardiovascular friendly natural products have been suggested.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00033
Harshitha V., Vivek D., Jaipal S.
Microencapsulation is the process of encasing, coating, or surrounding a very small droplet of particle, such as a solid, liquid, or even a gas, with a polymeric particle. In comparison to other parenteral controlled release dosage forms, such as macro-sized implants, microparticles offer a number of important benefits as drug delivery systems, including I an efficient protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the ability to precisely control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration, and (iv) desired, pre-programmed drug release. There are various methods to chemically encapsulate the substance, including the coacervation approach, the polymeric-polymeric incompatibility method, and the physical method, which include the centrifugal extrusion process, pan coating, spray drying, and the air suspension method. Core material, which is the required substance to be coated, and coating material are the most crucial materials utilised in microencapsulation (which is capable of forming film). Because it applies to the pharmaceutical, agricultural, food, and construction industries. Due to its precise action and minimal adverse effects, it is a better drug delivery technique than conventional drug delivery systems.
{"title":"A Cutting-Edge Method for Regulated Drug Delivery - Microencapsulation","authors":"Harshitha V., Vivek D., Jaipal S.","doi":"10.52711/0975-4377.2023.00033","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00033","url":null,"abstract":"Microencapsulation is the process of encasing, coating, or surrounding a very small droplet of particle, such as a solid, liquid, or even a gas, with a polymeric particle. In comparison to other parenteral controlled release dosage forms, such as macro-sized implants, microparticles offer a number of important benefits as drug delivery systems, including I an efficient protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the ability to precisely control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration, and (iv) desired, pre-programmed drug release. There are various methods to chemically encapsulate the substance, including the coacervation approach, the polymeric-polymeric incompatibility method, and the physical method, which include the centrifugal extrusion process, pan coating, spray drying, and the air suspension method. Core material, which is the required substance to be coated, and coating material are the most crucial materials utilised in microencapsulation (which is capable of forming film). Because it applies to the pharmaceutical, agricultural, food, and construction industries. Due to its precise action and minimal adverse effects, it is a better drug delivery technique than conventional drug delivery systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solid lipid nanoparticles (SLNs) are introduced as an efficient carrier method for correcting dynamic medicine and water-soluble medication. Fexofenadine HCl is a long-acting selective histamine (H1) receptor antagonist with anti-inflammatory properties of the second generation. Allergic rhinitis, angioedema, and chronic urticaria are treated with fexofenadine HCl. Solid lipid nanoparticles were prepared by hot homogenization method using a solid lipid of and different polymers. A solid lipid nanoparticle created by drug and polymer poloxamer 188 in ratio showed highest entrapment efficiency as well as drug release of the medication from the solid lipid nanoparticle formulation. The prepared nanoparticles were used to formulate the nanogel using Carbopol 934. The nano-drug delivery system developed by the hot homogenization method has demonstrated their suitability for a topical route for the treatment of skin allergy. Thus, the studies revealed that the developed system has a great appeal for the convenient treatment of dermatological allergy that may overcome in improving the limitations of the existing drug delivery system. Fexofenadine HCl is a white colored powder. It is practically insoluble in water and soluble in methanol. The melting point was found to be 194.1-195.2. The FTIR spectra of Fexofenadine HCl and the mixture of drug and excipients used in the formulation of nanoparticles reveal that there was no significant interaction between the drug and polymer and other excipients used in the formulation. The optimized batches (F2) showed highest entrapment efficiency. It was observed that as there is increase in concentration of surfactant increases the entrapment efficiency. The optimized solid lipid nanoparticle formulation showed maximum drug release within 6 hr. This showed that the increase in the concentration of surfactant there was increase in drug release from the SLN.
{"title":"Preparation and Optimization of Fexofenadine HCl Solid lipid Nanoparticles","authors":"Ashwini Gunjote, Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain","doi":"10.52711/0975-4377.2023.00025","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00025","url":null,"abstract":"Solid lipid nanoparticles (SLNs) are introduced as an efficient carrier method for correcting dynamic medicine and water-soluble medication. Fexofenadine HCl is a long-acting selective histamine (H1) receptor antagonist with anti-inflammatory properties of the second generation. Allergic rhinitis, angioedema, and chronic urticaria are treated with fexofenadine HCl. Solid lipid nanoparticles were prepared by hot homogenization method using a solid lipid of and different polymers. A solid lipid nanoparticle created by drug and polymer poloxamer 188 in ratio showed highest entrapment efficiency as well as drug release of the medication from the solid lipid nanoparticle formulation. The prepared nanoparticles were used to formulate the nanogel using Carbopol 934. The nano-drug delivery system developed by the hot homogenization method has demonstrated their suitability for a topical route for the treatment of skin allergy. Thus, the studies revealed that the developed system has a great appeal for the convenient treatment of dermatological allergy that may overcome in improving the limitations of the existing drug delivery system. Fexofenadine HCl is a white colored powder. It is practically insoluble in water and soluble in methanol. The melting point was found to be 194.1-195.2. The FTIR spectra of Fexofenadine HCl and the mixture of drug and excipients used in the formulation of nanoparticles reveal that there was no significant interaction between the drug and polymer and other excipients used in the formulation. The optimized batches (F2) showed highest entrapment efficiency. It was observed that as there is increase in concentration of surfactant increases the entrapment efficiency. The optimized solid lipid nanoparticle formulation showed maximum drug release within 6 hr. This showed that the increase in the concentration of surfactant there was increase in drug release from the SLN.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The solubility and dissolution rate of Atorvastatin, a drug used for the treatment of hyperlipidaemia. Atorvastatin is a selective competitive inhibitor of HMG Co-A reductase. However its absolute bioavailability is 5%. To increase the solubility of drug solid dispersion was prepared. Solid dispersion preliminary solubility analysis was carried out for the selection of the carrier and solid dispersion was prepared with Hydroxy Propyl Methyl Cellulose (HPMC) and Methyl Cellulose (MC). These solid dispersions were analyzed for the solubility and in-vitro dissolution profile solid dispersion of drug with polymer has shown enhanced solubility with improved dissolution rate. Further FTIR, X-Ray studies were carried out. Solid dispersion prepared with polymer in 1:5 ratios shows the presence of amorphous form confirmed by the characterization study. The present investigations showed that solubility of Atorvastatin Sodium was markedly increased by its solid dispersion using PVP K30 as carrier. The formulation SDF8 containing (1:8) shows highest dissolution rate. Hence the solid dispersion a way is useful technique in providing fastest onset of action of Atorvastatin Sodium as well as enhanced dissolution rate. The study also shows that dissolution rate of pravastatin can be enhanced to considerable extent by solid dispersion technique with Polymer.
{"title":"Design and Formulation for Enhancement of Solubility and Dissolution Rate of Atorvastatin using Solid Dispersion","authors":"Abhishek Kumar Yadav, Naveen Gupta, Neeraj Sharma, Dharmendra S. Rajput, Ankita Shukla","doi":"10.52711/0975-4377.2023.00035","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00035","url":null,"abstract":"The solubility and dissolution rate of Atorvastatin, a drug used for the treatment of hyperlipidaemia. Atorvastatin is a selective competitive inhibitor of HMG Co-A reductase. However its absolute bioavailability is 5%. To increase the solubility of drug solid dispersion was prepared. Solid dispersion preliminary solubility analysis was carried out for the selection of the carrier and solid dispersion was prepared with Hydroxy Propyl Methyl Cellulose (HPMC) and Methyl Cellulose (MC). These solid dispersions were analyzed for the solubility and in-vitro dissolution profile solid dispersion of drug with polymer has shown enhanced solubility with improved dissolution rate. Further FTIR, X-Ray studies were carried out. Solid dispersion prepared with polymer in 1:5 ratios shows the presence of amorphous form confirmed by the characterization study. The present investigations showed that solubility of Atorvastatin Sodium was markedly increased by its solid dispersion using PVP K30 as carrier. The formulation SDF8 containing (1:8) shows highest dissolution rate. Hence the solid dispersion a way is useful technique in providing fastest onset of action of Atorvastatin Sodium as well as enhanced dissolution rate. The study also shows that dissolution rate of pravastatin can be enhanced to considerable extent by solid dispersion technique with Polymer.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00031
Vinutha B. V., Sheeba F. R.
Hydrogels are three-dimensional cross-linked networks of polymer chains that can absorb and hold lots of water in the interstitial spaces between chains. Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involves much expense and time. The efficacy of drugs is affected by several factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH-sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pKavalues on the ionization, consequent swelling, and targeted drug release are also highlighted.
{"title":"pH Sensitive Hydrogel: A Review","authors":"Vinutha B. V., Sheeba F. R.","doi":"10.52711/0975-4377.2023.00031","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00031","url":null,"abstract":"Hydrogels are three-dimensional cross-linked networks of polymer chains that can absorb and hold lots of water in the interstitial spaces between chains. Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involves much expense and time. The efficacy of drugs is affected by several factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH-sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pKavalues on the ionization, consequent swelling, and targeted drug release are also highlighted.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.52711/0975-4377.2023.00032
Prajakta P. Shinde, Suvarna J. Shelke, Sneha K. Sonawane, Pratiksha R. Pawar
Nowdays, variety of food available in the market, which have serious health, environmental and social influence. Their consumption is not good for health. Due to all these things, people are fighting with many diseases like diabetes, obesity, cancer, osteoporosis and other allergic health related issues. For these purpose Nutraceuticals are the immunity booster that help to prevent disease and maintain normal body function, mostly COVID -19 disease the Nutraceuticals have developed as potential compounds to attenuate the COVID-19 complications. In particular, these food additives improve a person's immunity and augment the overall COVID treatment. Due to their greater cost and widespread use in nearly every home, these chemicals have been employed extensively. Simple access. Various drugs Nutraceutical interactions have also been elaborated with various examples in this review. This review summarizes the classification of Nutraceuticls like traditional, nontraditional etc.
{"title":"A Review on Nutraceuticals and its Classification","authors":"Prajakta P. Shinde, Suvarna J. Shelke, Sneha K. Sonawane, Pratiksha R. Pawar","doi":"10.52711/0975-4377.2023.00032","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00032","url":null,"abstract":"Nowdays, variety of food available in the market, which have serious health, environmental and social influence. Their consumption is not good for health. Due to all these things, people are fighting with many diseases like diabetes, obesity, cancer, osteoporosis and other allergic health related issues. For these purpose Nutraceuticals are the immunity booster that help to prevent disease and maintain normal body function, mostly COVID -19 disease the Nutraceuticals have developed as potential compounds to attenuate the COVID-19 complications. In particular, these food additives improve a person's immunity and augment the overall COVID treatment. Due to their greater cost and widespread use in nearly every home, these chemicals have been employed extensively. Simple access. Various drugs Nutraceutical interactions have also been elaborated with various examples in this review. This review summarizes the classification of Nutraceuticls like traditional, nontraditional etc.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aceclofenac is an oxyacetic and non-steroidal anti-inflammatory drug which has a half-life of 4 h. Aceclofenac is used to reduce fever, inflammation of rheumatoid arthritis, traumatic pain etc. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of aceclofenac microsphere is carried out to achieve sustained release of the drug after administration. The objective of this study was to find out the role of natural gum (Guar gum) for the preparation of microspheres. So, the amounts of natural gum were increased in various formulation at a successive rate. Aceclofenac microsphere is microencapsulated with guar gum and sodium alginate by Ionotropic gelation technique. There are various formulations of microspheres are developed. The prepared microspheres were spherical in shape, white in color and free flowing. Formulated microspheres were characterized for particle size, entrapment efficiency and in vitro drug release study. The aceclofenac microsphere showed particle size ranging from 330±10µm to 210±11µm 86.5% drug entrapment efficiency. The in vitro drug release is carried out up to 9 h in pH 6.8 phosphate buffer solution. F5 formulation showed maximum drug release of about 95.40% after 9 hour.
{"title":"Preparation and Evaluation of Aceclofenac microsphere containing Natural gum","authors":"Mahua Bera, Suman Pattanayak, Lakshmi Kanta Kanthal, Lagnajit Mahapatra, Ayan Pani, Souranava Jana, Sonaram Pal, Suprabhat Das, Aniruddha Maity, Debjit Maity","doi":"10.52711/0975-4377.2023.00027","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00027","url":null,"abstract":"Aceclofenac is an oxyacetic and non-steroidal anti-inflammatory drug which has a half-life of 4 h. Aceclofenac is used to reduce fever, inflammation of rheumatoid arthritis, traumatic pain etc. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of aceclofenac microsphere is carried out to achieve sustained release of the drug after administration. The objective of this study was to find out the role of natural gum (Guar gum) for the preparation of microspheres. So, the amounts of natural gum were increased in various formulation at a successive rate. Aceclofenac microsphere is microencapsulated with guar gum and sodium alginate by Ionotropic gelation technique. There are various formulations of microspheres are developed. The prepared microspheres were spherical in shape, white in color and free flowing. Formulated microspheres were characterized for particle size, entrapment efficiency and in vitro drug release study. The aceclofenac microsphere showed particle size ranging from 330±10µm to 210±11µm 86.5% drug entrapment efficiency. The in vitro drug release is carried out up to 9 h in pH 6.8 phosphate buffer solution. F5 formulation showed maximum drug release of about 95.40% after 9 hour.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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