Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00008
Snehal A Kurhe, K. Katkar, Anuja Bakkam, Simran Mokal, A. Mane, Ashish Jain
Effective ocular medication administration is still a difficulty for pharmaceutical scientists in the current drug delivery situation, despite various scientific endeavours. In the ocular drug delivery system, several topical medication applications in the form of solutions, suspensions, and ointments are used to treat eye infections. As a result of several anatomical and pathophysiological barriers present in the eye, many conventional dose forms have issues with poor ocular bioavailability due to short ocular residence times. Many recent available medications have weak solubility, which causes key challenges during formulation and exhibits poor bioavailability. The issue is significantly more complicated for medications that fall under BCS Class II. Nanotechnology is utilised to increase the solubility and bioavailability of poorly soluble medications in order to solve these issues. This review provides an insight into an overview of ocular challenges to anterior section delivery and strategies for removing these obstacles using nanocarrier technology. In addition to addressing the issues of poor solubility and bioavailability, nanosuppension also impacts the pharmacokinetics of the drug, enhancing its efficacy and safety.
{"title":"Ocular Nanosuspension a Novel Approach – Review","authors":"Snehal A Kurhe, K. Katkar, Anuja Bakkam, Simran Mokal, A. Mane, Ashish Jain","doi":"10.52711/0975-4377.2023.00008","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00008","url":null,"abstract":"Effective ocular medication administration is still a difficulty for pharmaceutical scientists in the current drug delivery situation, despite various scientific endeavours. In the ocular drug delivery system, several topical medication applications in the form of solutions, suspensions, and ointments are used to treat eye infections. As a result of several anatomical and pathophysiological barriers present in the eye, many conventional dose forms have issues with poor ocular bioavailability due to short ocular residence times. Many recent available medications have weak solubility, which causes key challenges during formulation and exhibits poor bioavailability. The issue is significantly more complicated for medications that fall under BCS Class II. Nanotechnology is utilised to increase the solubility and bioavailability of poorly soluble medications in order to solve these issues. This review provides an insight into an overview of ocular challenges to anterior section delivery and strategies for removing these obstacles using nanocarrier technology. In addition to addressing the issues of poor solubility and bioavailability, nanosuppension also impacts the pharmacokinetics of the drug, enhancing its efficacy and safety.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81507343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00009
Aladin Khalaf Alla Elhaj Eltahir, Hindustan Abdul Ahad, C. Haranath, Bake Meharajunnisa, Siriguppa Dheeraj, Badiginchala Navya Sai
The present afford is to express phytosomes as a tool for aqueous and non-aqueous drug permeation. Phytosomes are prepared by conventional dynamic plant constituents like phospholipid (PL). Phytosomes build the interest of traditionalists in homegrown concentrates, in any case, energetic standards both orally and topically. Extensive literature from reputed journals was gathered and listed various drugs so far tried in the past decade. The phytosomes are capable of being used to induce acute and chronic liver failure due to enhanced pharmacological and pharmacokinetic assets. Phytosomes have successfully entered the market and are not well known as they are in the patent lock period. The study concludes that phytosomes are promising dosage forms for the delivery of plant extracts, which consist of both polar and non-polar constituents.
{"title":"Novel Phytosomes as Drug Delivery Systems and its Past Decade Trials","authors":"Aladin Khalaf Alla Elhaj Eltahir, Hindustan Abdul Ahad, C. Haranath, Bake Meharajunnisa, Siriguppa Dheeraj, Badiginchala Navya Sai","doi":"10.52711/0975-4377.2023.00009","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00009","url":null,"abstract":"The present afford is to express phytosomes as a tool for aqueous and non-aqueous drug permeation. Phytosomes are prepared by conventional dynamic plant constituents like phospholipid (PL). Phytosomes build the interest of traditionalists in homegrown concentrates, in any case, energetic standards both orally and topically. Extensive literature from reputed journals was gathered and listed various drugs so far tried in the past decade. The phytosomes are capable of being used to induce acute and chronic liver failure due to enhanced pharmacological and pharmacokinetic assets. Phytosomes have successfully entered the market and are not well known as they are in the patent lock period. The study concludes that phytosomes are promising dosage forms for the delivery of plant extracts, which consist of both polar and non-polar constituents.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84956811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00007
K. Patel, Rajendra Chouksey
In recent years, gastro-retentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), muco-adhesive, expandable, unfold able, super porous hydrogel systems, and magnetic systems.
{"title":"A Recent Advantage on Gastroretentive Drug Delivery System: An Overview","authors":"K. Patel, Rajendra Chouksey","doi":"10.52711/0975-4377.2023.00007","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00007","url":null,"abstract":"In recent years, gastro-retentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), muco-adhesive, expandable, unfold able, super porous hydrogel systems, and magnetic systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80813760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00012
Dhananjay D. Chaudhari, Darshana M. Boarse, Paresh A. Patil, Neha R. Jaiswal
Over-the-counter (OTC) medications can help people manage their symptoms on their own. However, addiction and harm are increasingly recognized, and some OTC medications can be used. This review describes the current knowledge and understanding of OTC drug abuse. Practicing self-care and self-healing is an important part of a health care regimen System. Using over-the-counter (OTC) medications is part of the self-medication process. The popularity of OTC medications among patients may increase OTC abuse Drug. Because it is available as a prescription drug, it is often the first choice for patients and has the potential to educate and advise patients on OTCs. Drug use. The presence of a pharmacist ensures the safe and effective use of OTC drugs. Pharmacists may interact with other health professionals in managing self-care practices Patients. However, pharmacists are not usually employed in this role. This article provides A brief overview of OTC drugs with abuse potential and the impact of self-medication on OTC Drug. This review further explains the challenges faced by pharmacists in managing the use of OTC medications, given the new potential for OTC-prescription diversion. Year. In addition, the drug’s potential to improve the patient’s pharmacology Interactions are discussed. Current reviews support the positive role played by pharmacists Management of OTC drug abuse. This review contributes to the knowledge base of barriers Confronts the pharmacy to prevent the use of OTC drugs by developing appropriate intervention strategies.
{"title":"A Short Review on Misuse of Over-the-Counter Drugs","authors":"Dhananjay D. Chaudhari, Darshana M. Boarse, Paresh A. Patil, Neha R. Jaiswal","doi":"10.52711/0975-4377.2023.00012","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00012","url":null,"abstract":"Over-the-counter (OTC) medications can help people manage their symptoms on their own. However, addiction and harm are increasingly recognized, and some OTC medications can be used. This review describes the current knowledge and understanding of OTC drug abuse. Practicing self-care and self-healing is an important part of a health care regimen System. Using over-the-counter (OTC) medications is part of the self-medication process. The popularity of OTC medications among patients may increase OTC abuse Drug. Because it is available as a prescription drug, it is often the first choice for patients and has the potential to educate and advise patients on OTCs. Drug use. The presence of a pharmacist ensures the safe and effective use of OTC drugs. Pharmacists may interact with other health professionals in managing self-care practices Patients. However, pharmacists are not usually employed in this role. This article provides A brief overview of OTC drugs with abuse potential and the impact of self-medication on OTC Drug. This review further explains the challenges faced by pharmacists in managing the use of OTC medications, given the new potential for OTC-prescription diversion. Year. In addition, the drug’s potential to improve the patient’s pharmacology Interactions are discussed. Current reviews support the positive role played by pharmacists Management of OTC drug abuse. This review contributes to the knowledge base of barriers Confronts the pharmacy to prevent the use of OTC drugs by developing appropriate intervention strategies.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85188268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00003
Akhlaq Mustafa, Umar Hussain, Anas Iqbal Alvi, G. Javed, Asim Ali Khan
Unani system of medicines classifies its formulation into several classes e. g. Huboob, Sufoof, Qurs, Sufoofs, Majoon, Arq, Roughan, Kushta etc. Among the various dosage forms of Unani system of medicine Sharbat Toot Siyah is one of the renowned formulations whichis widely used for the number of ailments e.g. Pharyngeal pain and sore throat. The drug Sharbat Toot Siyah was in-house manufactured in three batches of different volumes of 500, 600 and 700ml following the SOP guidelines and underwent for the evaluation of secondary metabolite constituents Profile with Physico-chemical Standardization of this important poly-herbal formulation. The present work contributes to the development of standardization parameters of herbal drugs used in Indian system of medicine like morphological properties, viscosity, pH values, ash values, extractive values, alcohol soluble matter, specific gravity at 25ºC, refractive index, sugar quantity e. g. total sugar, reducing sugar and non-reducing sugar, qualitative and quantitative inorganic elements, phyto-constituents and thin layer chromatography. In preliminary phytochemical investigation, analysis showed the presence of organic constituent’s amino acids, tannins, phyto-sterols, flavanoids and glycosides in the extract while in the elemental analysis, calcium, magnesium, phosphorous etc. were found to be present. The study also includes quality control parameters e. g. aflatoxins, microbial load, pesticide residue and detection of heavy metals which are helpful to ensure the purity, safety and efficacy of herbal formulation. The results so obtained for the various Physico-chemical tests may be taken as standard values for future reference.
{"title":"Studies Leading to Phyto and Physico-chemical Evaluation of an important Polypharmaceutical preparation (Syrup) \"Sharbat Toot Siyah\"- A Drug of Choice","authors":"Akhlaq Mustafa, Umar Hussain, Anas Iqbal Alvi, G. Javed, Asim Ali Khan","doi":"10.52711/0975-4377.2023.00003","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00003","url":null,"abstract":"Unani system of medicines classifies its formulation into several classes e. g. Huboob, Sufoof, Qurs, Sufoofs, Majoon, Arq, Roughan, Kushta etc. Among the various dosage forms of Unani system of medicine Sharbat Toot Siyah is one of the renowned formulations whichis widely used for the number of ailments e.g. Pharyngeal pain and sore throat. The drug Sharbat Toot Siyah was in-house manufactured in three batches of different volumes of 500, 600 and 700ml following the SOP guidelines and underwent for the evaluation of secondary metabolite constituents Profile with Physico-chemical Standardization of this important poly-herbal formulation. The present work contributes to the development of standardization parameters of herbal drugs used in Indian system of medicine like morphological properties, viscosity, pH values, ash values, extractive values, alcohol soluble matter, specific gravity at 25ºC, refractive index, sugar quantity e. g. total sugar, reducing sugar and non-reducing sugar, qualitative and quantitative inorganic elements, phyto-constituents and thin layer chromatography. In preliminary phytochemical investigation, analysis showed the presence of organic constituent’s amino acids, tannins, phyto-sterols, flavanoids and glycosides in the extract while in the elemental analysis, calcium, magnesium, phosphorous etc. were found to be present. The study also includes quality control parameters e. g. aflatoxins, microbial load, pesticide residue and detection of heavy metals which are helpful to ensure the purity, safety and efficacy of herbal formulation. The results so obtained for the various Physico-chemical tests may be taken as standard values for future reference.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89962986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/2349-2988.2022.00041
Ganesh R. Bharskar, Pratik Malvade
Favipiravir is an antiviral drug that has been shown to treat a variety of life-threatening infections, including Ebola, Lassa, and the COVID-19 virus. It's a pyrazine carboxamide derivative with antiviral action that targets RNA-dependent RNA polymerase enzymes, which are required for viral genome transcription and replication. Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. The nucleoside analogue favipiravir is rapidly metabolized in host cells which disrupts viral synthesis and leads to mutagenesis The mechanism of action of the Favipiravir and Side effects like QTc prolongation or teratogenicity pose risk to extensive community application discusses in this review. In this article, we have tried to provide a comprehensive, evidence-based review of this drug about synthesis, Pharmacology, Mechanism of Action, Antiviral activity, Consequences.
{"title":"Favipiravir: An Antiviral Drug","authors":"Ganesh R. Bharskar, Pratik Malvade","doi":"10.52711/2349-2988.2022.00041","DOIUrl":"https://doi.org/10.52711/2349-2988.2022.00041","url":null,"abstract":"Favipiravir is an antiviral drug that has been shown to treat a variety of life-threatening infections, including Ebola, Lassa, and the COVID-19 virus. It's a pyrazine carboxamide derivative with antiviral action that targets RNA-dependent RNA polymerase enzymes, which are required for viral genome transcription and replication. Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. The nucleoside analogue favipiravir is rapidly metabolized in host cells which disrupts viral synthesis and leads to mutagenesis The mechanism of action of the Favipiravir and Side effects like QTc prolongation or teratogenicity pose risk to extensive community application discusses in this review. In this article, we have tried to provide a comprehensive, evidence-based review of this drug about synthesis, Pharmacology, Mechanism of Action, Antiviral activity, Consequences.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80252095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/2349-2988.2022.00042
Sejal M. Karwa, Dattaprasad N. Vikhe, Ravindra S. Jadhav
Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. A scrutiny of literature revealed some notable pharmacological activities of the plant such as antidiabetic, antiobesity, hypolipidaemic, antimicrobial, free radical scavenging and anti-inflammatory. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. Efforts have been made to prepare gudmar dried extract. These extracts were subjected for preliminary qualitative analysis, quantitative estimation of terpenoides, alkaloids and various other compounds. The present review is an attempt to highlight the phytochemical screening as well as its extraction process. Also chromatographic studies gave the presence of different compounds which can be used in creating monograph for this species.
{"title":"A Review on Phytochemical Investigation of Gymnema sylvestre Leaves","authors":"Sejal M. Karwa, Dattaprasad N. Vikhe, Ravindra S. Jadhav","doi":"10.52711/2349-2988.2022.00042","DOIUrl":"https://doi.org/10.52711/2349-2988.2022.00042","url":null,"abstract":"Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. A scrutiny of literature revealed some notable pharmacological activities of the plant such as antidiabetic, antiobesity, hypolipidaemic, antimicrobial, free radical scavenging and anti-inflammatory. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. Efforts have been made to prepare gudmar dried extract. These extracts were subjected for preliminary qualitative analysis, quantitative estimation of terpenoides, alkaloids and various other compounds. The present review is an attempt to highlight the phytochemical screening as well as its extraction process. Also chromatographic studies gave the presence of different compounds which can be used in creating monograph for this species.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73882421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00049
Bagul Mahesh B., Surawase Rajendra K.
This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.
{"title":"Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of COVID-19","authors":"Bagul Mahesh B., Surawase Rajendra K.","doi":"10.52711/0975-4377.2022.00049","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00049","url":null,"abstract":"This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80034260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00045
Patil Swati P, Pati Ashwini V, B. M. M., Barhate S. D., M. Nasir
The aim of this study was to prepare ODT of taste masked levocetrizine dihydrochloride by using ion exchange resin. Levocetrizine Dihydrochloride is bitter in taste, Kyron T-134 a weak cationic exchange resin was used to mask the bitter taste of the drug. The ODTs were prepared by using drug-resin (DRC) complex using batch process. Compression of ODTs was done by using direct compression method with the technique of addition of superdisintegrants. Central composite design (CCD) was applied as an optimization technique. FTIR and DSC studies indicated drug and excipients were compatible with each other. The prepared orodispersible tablet blend and tablets were evaluated for various pre-compression and post-compression parameters. The Batch LH3 was given as optimized batch by central composite design. This optimized batch LH3 was passed all the pre-compression and post- compression parameters. The prepared ODTS showed successfully rapid onset of action with decrease in disintegration time 26 sec and %drug released was found to be 98.26%. It was concluded that levocetrizine dihydrochloride ODTs were prepared successfully by taste masking method using Kyron T-134 ion exchange resin and croscarmellose sodium as Superdisintegrant using CCD. AS per CDER guidelines, it shows DT within 5-30 sec.
{"title":"Formulation Optimization and Evaluation of Taste Masked Oro-dispersible Tablet of Levocetrizine Dihydrochloride by Ion Exchange Resin","authors":"Patil Swati P, Pati Ashwini V, B. M. M., Barhate S. D., M. Nasir","doi":"10.52711/0975-4377.2022.00045","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00045","url":null,"abstract":"The aim of this study was to prepare ODT of taste masked levocetrizine dihydrochloride by using ion exchange resin. Levocetrizine Dihydrochloride is bitter in taste, Kyron T-134 a weak cationic exchange resin was used to mask the bitter taste of the drug. The ODTs were prepared by using drug-resin (DRC) complex using batch process. Compression of ODTs was done by using direct compression method with the technique of addition of superdisintegrants. Central composite design (CCD) was applied as an optimization technique. FTIR and DSC studies indicated drug and excipients were compatible with each other. The prepared orodispersible tablet blend and tablets were evaluated for various pre-compression and post-compression parameters. The Batch LH3 was given as optimized batch by central composite design. This optimized batch LH3 was passed all the pre-compression and post- compression parameters. The prepared ODTS showed successfully rapid onset of action with decrease in disintegration time 26 sec and %drug released was found to be 98.26%. It was concluded that levocetrizine dihydrochloride ODTs were prepared successfully by taste masking method using Kyron T-134 ion exchange resin and croscarmellose sodium as Superdisintegrant using CCD. AS per CDER guidelines, it shows DT within 5-30 sec.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88110720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00052
Supriya Vinod Pote, Kedar Bavaskar, Ashish Jain
Solubility is the process of a solid dissolving in a liquid phase, resulting in a homogeneous system. Solubility is a crucial characteristic for achieving the appropriate drug concentration in the systemic circulation and demonstrating pharmacological response. Drugs that are poorly water soluble require substantial dosages to achieve therapeutic plasma concentrations following oral administration. Low aqueous solubility is a major issue in the development of novel chemical entities' formulations. Any medicine that needs to be absorbed must be in the form of an aqueous solution at the absorption site. For liquid medicinal compositions, water is the preferred solvent. The majority of medications are weakly acidic and basic, with low water solubility. Micronization, chemical modification, pH adjustment, solid dispersion, complexation, cosolvency, micellar solubilization, hydrotropy, and other procedures are used to increase the solubility of weakly water-soluble pharmaceuticals. The goal of this review paper is to present solubilization approaches for achieving optimal absorption and increased bioavailability.
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