The neighborhood populace of El Bayad city addresses the current study to realize medicinal plants utilized in natural medication customary and the effect of these plants in human pathogenic microbes and parasites treatment. Our results got made it conceivable to distinguish 64 restorative species having a place with 37 plant families. The fundamental family is the Lamiaceae.The entire plants and the leaves are the most utilized part, and most cures are ready as maceration and decoctions. These homegrown cures are controlled orally, particularly as natural tea. Of the relative multitude of sicknesses treated, gastrointestinal issues, for example, torment and ulcers in the stomach and throat brought about by growths are the most moved for inner therapy, and the most well-known illnesses for therapy outside it is skin illnesses, for example, psoriasis, skin aggravations, and scalp issues brought about by organisms and microbes.
El Bayad市的社区居民提出了目前的研究，以了解天然药物习惯中使用的药用植物以及这些植物在人类病原微生物和寄生虫治疗中的作用。结果表明，在37个植物科中，有64种恢复物种可以被区分出来。最基本的科是Lamiaceae。整个植物和叶子是利用最多的部分，大多数治疗方法是浸泡和煎煮。这些本土的治疗方法是口服控制的，特别是作为天然茶。在治疗的相对众多的疾病中，胃肠道疾病，例如，由生长引起的胃和喉咙的折磨和溃疡是最适合内部治疗的，而最著名的外部治疗疾病是皮肤疾病，例如，牛皮癣，皮肤恶化，以及由生物体和微生物引起的头皮问题。
{"title":"Ethnobotanical Study of Antifungal Medicinal plant in the region of El Bayadh (Algeria)","authors":"Mustapha Mahmoud Dif, Omar Alami, Amel Haderia Benchohra, Naima Allali","doi":"10.52711/0975-4377.2023.00014","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00014","url":null,"abstract":"The neighborhood populace of El Bayad city addresses the current study to realize medicinal plants utilized in natural medication customary and the effect of these plants in human pathogenic microbes and parasites treatment. Our results got made it conceivable to distinguish 64 restorative species having a place with 37 plant families. The fundamental family is the Lamiaceae.The entire plants and the leaves are the most utilized part, and most cures are ready as maceration and decoctions. These homegrown cures are controlled orally, particularly as natural tea. Of the relative multitude of sicknesses treated, gastrointestinal issues, for example, torment and ulcers in the stomach and throat brought about by growths are the most moved for inner therapy, and the most well-known illnesses for therapy outside it is skin illnesses, for example, psoriasis, skin aggravations, and scalp issues brought about by organisms and microbes.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-18DOI: 10.52711/0975-4377.2023.00023
Mukul Rajgure, Pallavi Wadaskar, Komal Nirale
Gels formed in situ have quickly emerged as one of the most widely used and easily accessible methods. These systems have a number of advantages, including simple production, ease of use, enhanced adherence, and patient comfort by limiting the amount of times drugs need to be administered due to its one-of-a-kind characteristics, which include a sol-to-gel transition. The precursor is subjected to hydrolysis as well as polymerization or condensation in the ‘sol-gel' process, which ultimately results in the production of a colloidal suspension or solution. In spite of the fact that these in situ gelling systems can be administered in solution form, the gelation process takes place at the achievement site. Recent years have seen the development of in situ gelling systems for liposomes, microspheres, nanoemulsions, nanospheres, and other similar structures by a few researchers. This review primarily concentrated on the introduction, followed by a discussion of the benefits, drawbacks, different types of polymers, and desirable qualities for the preparation of in situ gels.
{"title":"A Review on the many different types of Polymers that are Utilized in the Production of in Situ Gels","authors":"Mukul Rajgure, Pallavi Wadaskar, Komal Nirale","doi":"10.52711/0975-4377.2023.00023","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00023","url":null,"abstract":"Gels formed in situ have quickly emerged as one of the most widely used and easily accessible methods. These systems have a number of advantages, including simple production, ease of use, enhanced adherence, and patient comfort by limiting the amount of times drugs need to be administered due to its one-of-a-kind characteristics, which include a sol-to-gel transition. The precursor is subjected to hydrolysis as well as polymerization or condensation in the ‘sol-gel' process, which ultimately results in the production of a colloidal suspension or solution. In spite of the fact that these in situ gelling systems can be administered in solution form, the gelation process takes place at the achievement site. Recent years have seen the development of in situ gelling systems for liposomes, microspheres, nanoemulsions, nanospheres, and other similar structures by a few researchers. This review primarily concentrated on the introduction, followed by a discussion of the benefits, drawbacks, different types of polymers, and desirable qualities for the preparation of in situ gels.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72764534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-18DOI: 10.52711/0975-4377.2023.00020
Mayur S. Mahajan, K. Bobe, B. Chavan
Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that belongs to the coronavirus family. The first case was reported in December 2019, and the disease has become a pandemic. Impaired immune regulation is one of the factors that play a role in its pathogenesis and results in poor outcomes of COVID-19 patients. There have been many studies with drug candidates used as antivirals or immunomodulators. However, the results of these investigations showed that the drug candidates were not significantly effective against the disease. Meanwhile, people believe that consuming herbal immunomodulators can prevent or even cure COVID-19. Unfortunately, specific preclinical and clinical trials to evaluate the effects of herbal immunoregulators have not been conducted. Certain natural compounds might be effective for the treatment of COVID-19 based on general concepts from previous experiments. This review discusses some herbal agents extracted from various plants, including Curcuma longa, Cinchona, Ashwagandh aand Lianhuaqingwen, which are considered for the treatment of COVID-19. In addition, we discuss the pros and cons of utilising herbal medicine during the COVID-19 pandemic, draw some conclusions, and make recommendations at the end of the session.
{"title":"Traditional Ayurvedic Formulation in the Management of COVID-19","authors":"Mayur S. Mahajan, K. Bobe, B. Chavan","doi":"10.52711/0975-4377.2023.00020","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00020","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that belongs to the coronavirus family. The first case was reported in December 2019, and the disease has become a pandemic. Impaired immune regulation is one of the factors that play a role in its pathogenesis and results in poor outcomes of COVID-19 patients. There have been many studies with drug candidates used as antivirals or immunomodulators. However, the results of these investigations showed that the drug candidates were not significantly effective against the disease. Meanwhile, people believe that consuming herbal immunomodulators can prevent or even cure COVID-19. Unfortunately, specific preclinical and clinical trials to evaluate the effects of herbal immunoregulators have not been conducted. Certain natural compounds might be effective for the treatment of COVID-19 based on general concepts from previous experiments. This review discusses some herbal agents extracted from various plants, including Curcuma longa, Cinchona, Ashwagandh aand Lianhuaqingwen, which are considered for the treatment of COVID-19. In addition, we discuss the pros and cons of utilising herbal medicine during the COVID-19 pandemic, draw some conclusions, and make recommendations at the end of the session.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83056901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00001
M. Swamy, Samyuktha Metta, A. A. Kumar, C. J. Mohan Reddy, G. Dharani, K. Ramya
Multiple Mixes have been proposed to have multitudinous uses including their use for improvement of bioavailability or as a dragged medicine delivery system. But the essential insecurity of this system needs to be overcome before they find implicit operation in medicinals. Multiple mixes are frequently stabilized using a combination of hydrophilic and hydrophobic surfactants. The rate of these surfactants is important in achieving stable multiple mixes. The purpose of the study was to prepare a stable multiple conflation containing a skin anti-aging agent and using paraffin oil emulsion. Vitamin C, was incorporated into the inner waterless phase of water- in- oil emulsion- in- water (w/ o/ w) multiple conflation at a attention of 1. Multiple conflation was prepared by two step system. Stability studies were performed at different accelerated conditions, i.e. 8°C (in refrigerator), 25°C (in roaster), 40°C(in roaster), and 40°C at 75 RH (in stability cabin) for 28 days to prognosticate the stability of phrasings. The ideal of this study was to prepare multiple conflation of Ascorbic acid by two step emulsification using different non-ionic surfactants, Tweens and Agar, and estimate for stability, chance medicine ruse. The study concluded that stable multiple conflation with high ruse effectiveness can be prepared by two step emulsification system using agar- agar primary emulsifier and Tween 80 as secondary emulsifier. F2 formulation is the best formulation than the F1 and F3 formulations based on phase separation and other tests.
{"title":"Formulation and Characterization of a multiple Emulsion containing Vitamin - C","authors":"M. Swamy, Samyuktha Metta, A. A. Kumar, C. J. Mohan Reddy, G. Dharani, K. Ramya","doi":"10.52711/0975-4377.2023.00001","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00001","url":null,"abstract":"Multiple Mixes have been proposed to have multitudinous uses including their use for improvement of bioavailability or as a dragged medicine delivery system. But the essential insecurity of this system needs to be overcome before they find implicit operation in medicinals. Multiple mixes are frequently stabilized using a combination of hydrophilic and hydrophobic surfactants. The rate of these surfactants is important in achieving stable multiple mixes. The purpose of the study was to prepare a stable multiple conflation containing a skin anti-aging agent and using paraffin oil emulsion. Vitamin C, was incorporated into the inner waterless phase of water- in- oil emulsion- in- water (w/ o/ w) multiple conflation at a attention of 1. Multiple conflation was prepared by two step system. Stability studies were performed at different accelerated conditions, i.e. 8°C (in refrigerator), 25°C (in roaster), 40°C(in roaster), and 40°C at 75 RH (in stability cabin) for 28 days to prognosticate the stability of phrasings. The ideal of this study was to prepare multiple conflation of Ascorbic acid by two step emulsification using different non-ionic surfactants, Tweens and Agar, and estimate for stability, chance medicine ruse. The study concluded that stable multiple conflation with high ruse effectiveness can be prepared by two step emulsification system using agar- agar primary emulsifier and Tween 80 as secondary emulsifier. F2 formulation is the best formulation than the F1 and F3 formulations based on phase separation and other tests.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74193087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00006
Y. Sirisha, Kurni Sai Kumar, R. Sri. S
The aim of the present study was to develop Stavudine extended release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Sodium CMC and HPMC 15cps were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 99.12% in 12 hours. It contains the Sodium CMC as polymer. It followed Kars Mayer peppas release kinetics mechanism.
{"title":"Formulation Development and In vitro Characterisation of Stavudine Extended Release Matrix Tablets","authors":"Y. Sirisha, Kurni Sai Kumar, R. Sri. S","doi":"10.52711/0975-4377.2023.00006","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00006","url":null,"abstract":"The aim of the present study was to develop Stavudine extended release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Sodium CMC and HPMC 15cps were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 99.12% in 12 hours. It contains the Sodium CMC as polymer. It followed Kars Mayer peppas release kinetics mechanism.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77249733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00004
Dethliya Madhuri, Jain Neetesh Kumar
Context: Although several formulation strategies have been developed for the treatment of psoriasis, there is an unmet need for optimization of its therapy. Objective: The objective was to develop a nanogel composed of Acitretin (ACT) loaded nanostructured lipid carrier (ACT-NLC) and to evaluate its potential in imiquimod-induced psoriasis model to ameliorate symptoms of psoriasis. Materials and methods: The developed control (CNGs) nanogels, acitretin loaded nanogels (ActCNGs) were characterized by UV and FTIR. Results and discussion: The systems were found to be spherical in shape with a size range of 98±10, and 138±8 nm having zeta potential values of +28±3 and +27±3 mV for CNGs and ActCNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin in psoriasis.
{"title":"Formulation and Evaluation of Nanogel used for the Treatment of Psorasis","authors":"Dethliya Madhuri, Jain Neetesh Kumar","doi":"10.52711/0975-4377.2023.00004","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00004","url":null,"abstract":"Context: Although several formulation strategies have been developed for the treatment of psoriasis, there is an unmet need for optimization of its therapy. Objective: The objective was to develop a nanogel composed of Acitretin (ACT) loaded nanostructured lipid carrier (ACT-NLC) and to evaluate its potential in imiquimod-induced psoriasis model to ameliorate symptoms of psoriasis. Materials and methods: The developed control (CNGs) nanogels, acitretin loaded nanogels (ActCNGs) were characterized by UV and FTIR. Results and discussion: The systems were found to be spherical in shape with a size range of 98±10, and 138±8 nm having zeta potential values of +28±3 and +27±3 mV for CNGs and ActCNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin in psoriasis.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78610941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00005
Shiva Srikrishna, Kasula Sadhana, R. Sri. S
In the present research work, we have designed a pulsatile formulation of Bosentan to treat High blood pressure as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration of polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical and In-vitro drug release studies. FTIR studies revealed that there was not any chemical reaction between pure drug Bosentan and polymers. The pre and post-compressional parameters of tablets were also found to be within limits. Our optimized formulation F-6 releases Bosentan after a lag time of 2 hours and 98.01 % up to 12 hours. Formulations were stable for at least 3 months under standard long-term and accelerated storage conditions.
{"title":"Formulation and Evaluation of Bosentan Pulsatile Drug Delivery System by using Press Coated Technique","authors":"Shiva Srikrishna, Kasula Sadhana, R. Sri. S","doi":"10.52711/0975-4377.2023.00005","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00005","url":null,"abstract":"In the present research work, we have designed a pulsatile formulation of Bosentan to treat High blood pressure as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration of polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical and In-vitro drug release studies. FTIR studies revealed that there was not any chemical reaction between pure drug Bosentan and polymers. The pre and post-compressional parameters of tablets were also found to be within limits. Our optimized formulation F-6 releases Bosentan after a lag time of 2 hours and 98.01 % up to 12 hours. Formulations were stable for at least 3 months under standard long-term and accelerated storage conditions.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73937204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00010
D. Singh, Manoj Kumar Mishra
From the past three decades there are huge changes and developments in formulation technology. Innovations in drug delivery systems are not only associated with the development of novel dosage forms but also with the development of new formulations using existing drugs for the treatment. These innovations in delivery of drug have many advantages like better patient compliance, maintenance of steady state concentration of drug for the prolong period, reducing dosing frequency, drug targeting to desired site of action and low side effects. TDDS are designed for delivery of drugs across the skin and it provides both controlled and continuous administration drug. It terminates the pulsed entry of drug in systemic circulation due to which side effects are observed. This transdermal route of drug delivery has more benefits and convenience than oral route and enhances the safety and efficacy of drug; it is patient friendly and painless device that provides regulated, uniform administration and the continuous supply of drug to targeted site for treatment of various diseases.
{"title":"A Recent Advance on Transdermal Drug Delivery System","authors":"D. Singh, Manoj Kumar Mishra","doi":"10.52711/0975-4377.2023.00010","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00010","url":null,"abstract":"From the past three decades there are huge changes and developments in formulation technology. Innovations in drug delivery systems are not only associated with the development of novel dosage forms but also with the development of new formulations using existing drugs for the treatment. These innovations in delivery of drug have many advantages like better patient compliance, maintenance of steady state concentration of drug for the prolong period, reducing dosing frequency, drug targeting to desired site of action and low side effects. TDDS are designed for delivery of drugs across the skin and it provides both controlled and continuous administration drug. It terminates the pulsed entry of drug in systemic circulation due to which side effects are observed. This transdermal route of drug delivery has more benefits and convenience than oral route and enhances the safety and efficacy of drug; it is patient friendly and painless device that provides regulated, uniform administration and the continuous supply of drug to targeted site for treatment of various diseases.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82291266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00002
T. Vijayalaxmi, Vunjali Laxman Sai, R. Sri. S
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Cytarabine and Daunorubicin, in its pure form as well as in pharmaceutical dosage form. Chromatography was carried out on an Altima C18 (4.6mm x 150mm, 5µm) column using a mixture of ACN, Methanol and Phosphate buffer pH-4.6 (10:25:65 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 265nm. The retention time of the Cytarabine and Daunorubicin was 2.088, 6.068±0.02 min respectively. The method produces linear responses in the concentration range of 10-50mg/ml of Cytarabine and 20-100mg/ml of Daunorubicin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
{"title":"HPLC Analytical Method Development and Validation for Estimation of Cytarabine and Daunorubicin in API and Pharmaceutical Formulation","authors":"T. Vijayalaxmi, Vunjali Laxman Sai, R. Sri. S","doi":"10.52711/0975-4377.2023.00002","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00002","url":null,"abstract":"A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Cytarabine and Daunorubicin, in its pure form as well as in pharmaceutical dosage form. Chromatography was carried out on an Altima C18 (4.6mm x 150mm, 5µm) column using a mixture of ACN, Methanol and Phosphate buffer pH-4.6 (10:25:65 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 265nm. The retention time of the Cytarabine and Daunorubicin was 2.088, 6.068±0.02 min respectively. The method produces linear responses in the concentration range of 10-50mg/ml of Cytarabine and 20-100mg/ml of Daunorubicin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91410455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.52711/0975-4377.2023.00011
Pradip Landge, J. Lavande, Avinash Swami, Vishweshwar M. Dharashive
The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. One novel approach in this area is Gastro Retentive Drug Delivery System (GRDDSs). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the, factors controlling gastric retention, advantages, Disadvantages and applications of gastroretentive drug delivery systems, Commonly used drug in formulation of GRDDS,Gastroretentive products available in the market, types of GRDDS.
{"title":"A Review on Gastroretentive Drug Delivery System","authors":"Pradip Landge, J. Lavande, Avinash Swami, Vishweshwar M. Dharashive","doi":"10.52711/0975-4377.2023.00011","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00011","url":null,"abstract":"The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. One novel approach in this area is Gastro Retentive Drug Delivery System (GRDDSs). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the, factors controlling gastric retention, advantages, Disadvantages and applications of gastroretentive drug delivery systems, Commonly used drug in formulation of GRDDS,Gastroretentive products available in the market, types of GRDDS.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77742524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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