Immunotherapy has revolutionized cancer treatment by leveraging the body's immune system to fight against cancer cells. This article provides an overview of immunotherapy, focusing on its different modalities, mechanisms of action, clinical applications, and the management of immune-related adverse events. Immune checkpoint inhibitors, such as PD-1 and CTLA-4 inhibitors, are prominent modalities that enhance the immune response by blocking regulatory proteins. Additionally, CAR-T therapy genetically modifies a patient's T cells to target specific proteins on cancer cells, leading to precise cancer cell elimination. Immunotherapy has demonstrated remarkable success in certain malignancies and offers new hope for patients battling cancer.
{"title":"Immunotherapy in Cancer Treatment: Harnessing the Power of the Immune System","authors":"Alok Kumar, Kanchan Singh, Kartik Kumar, Sachin Kumar, Arjun Singh, Alpesh Tripath, Lakshya Tiwari","doi":"10.52711/0975-4377.2024.00017","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00017","url":null,"abstract":"Immunotherapy has revolutionized cancer treatment by leveraging the body's immune system to fight against cancer cells. This article provides an overview of immunotherapy, focusing on its different modalities, mechanisms of action, clinical applications, and the management of immune-related adverse events. Immune checkpoint inhibitors, such as PD-1 and CTLA-4 inhibitors, are prominent modalities that enhance the immune response by blocking regulatory proteins. Additionally, CAR-T therapy genetically modifies a patient's T cells to target specific proteins on cancer cells, leading to precise cancer cell elimination. Immunotherapy has demonstrated remarkable success in certain malignancies and offers new hope for patients battling cancer.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00005
Rupali Rathod, Manoj Bari, Shaikh Samir
In the present research work, to formulation and evaluation of capsule-in-capsule technology for biphasic delivery of Glipizide. The advantages of fast releasing liquid-filled-capsules and slow release beads-filled-capsules were combined to meet the optimized requirements of our biphasic drug delivery system. Glipizide slow releasing beads were prepared by ionotrophic gelation method by using natural polymers like Sodium alginate, Pectin and were filled into a smaller capsule. Glipizide fast releasing liquid dispersion was prepared by using either Castor oil carriers and further prepared a glipizide emulsion. This fast releasing liquid and slow releasing beads-filled-capsule was further inserted into a bigger capsule body and Seal the capsule by hydro alcoholic solution. The various formulation batches were subjected to physicochemical studies, entrapment efficiency, drug content, in vitro drug release and stability studies. Interaction studies reveal that there was no interaction between drug and polymers employed in this study. The optimized capsule-in-a-capsule formulation released 22.65±0.74% of drug at the end of 30 min and 95.04±0.88% of drug at the end of 12h. The drug release profile of Glipizide capsule-in-a-capsule formulation fits well with Pepas model followed by zero order, first order and Korsemeyer-peppa’s model. Korsmeyer-Peppas model analysis indicated that the drug release followed non-Fickian transport mechanism. The stability results indicate that the various parameters of our optimized formulation are not affected on storage at 45°C/75%RH up to 4 months. Target of capsule-in-capsule drug delivery loading dose reaches therapeutic drug level in blood plasma for quicker onset of action and Maintenance dose which maintain an effective therapeutic level for prolong period. The prepared Glipizide biphasic cap-in-cap will be used for treatment of Diabetes.
{"title":"Formulation and Evaluation of Capsule-in-Capsule Technology for Biphasic delivery of Glipizide","authors":"Rupali Rathod, Manoj Bari, Shaikh Samir","doi":"10.52711/0975-4377.2024.00005","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00005","url":null,"abstract":"In the present research work, to formulation and evaluation of capsule-in-capsule technology for biphasic delivery of Glipizide. The advantages of fast releasing liquid-filled-capsules and slow release beads-filled-capsules were combined to meet the optimized requirements of our biphasic drug delivery system. Glipizide slow releasing beads were prepared by ionotrophic gelation method by using natural polymers like Sodium alginate, Pectin and were filled into a smaller capsule. Glipizide fast releasing liquid dispersion was prepared by using either Castor oil carriers and further prepared a glipizide emulsion. This fast releasing liquid and slow releasing beads-filled-capsule was further inserted into a bigger capsule body and Seal the capsule by hydro alcoholic solution. The various formulation batches were subjected to physicochemical studies, entrapment efficiency, drug content, in vitro drug release and stability studies. Interaction studies reveal that there was no interaction between drug and polymers employed in this study. The optimized capsule-in-a-capsule formulation released 22.65±0.74% of drug at the end of 30 min and 95.04±0.88% of drug at the end of 12h. The drug release profile of Glipizide capsule-in-a-capsule formulation fits well with Pepas model followed by zero order, first order and Korsemeyer-peppa’s model. Korsmeyer-Peppas model analysis indicated that the drug release followed non-Fickian transport mechanism. The stability results indicate that the various parameters of our optimized formulation are not affected on storage at 45°C/75%RH up to 4 months. Target of capsule-in-capsule drug delivery loading dose reaches therapeutic drug level in blood plasma for quicker onset of action and Maintenance dose which maintain an effective therapeutic level for prolong period. The prepared Glipizide biphasic cap-in-cap will be used for treatment of Diabetes.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00007
Pradnya D. Lahamge, Yashpal M. More, Pallavi P. Ahire, Vinay R. Kothawade
The category of gastroretentive drug delivery systems (GRDDS) includes floating drug delivery systems (FDDS). These dose formulations are intended to extend the duration of the stomach's residence period by a sustained release technique. Drugs which are harder to dissolve in high pH environments have improved bioavailability and solubility when incorporated into GRDDS. Reduced intestinal absorption of solid dose forms can be accomplished by the flotation mechanism. The novel fusion of bilayer and floating mechanism is demonstrated by the bilayer floating drug delivery device. It demonstrates the effective creation of a controlled release formulation. Bilayer floating tablets offer a sustained release layer formulation in addition to an immediate release. A attempt was made to explain the mechanism of FDDS, or floating bilayer, in the review. In order to accomplish regulated administration of various medications with predetermined release profiles, bi-layer tablets were developed. The pharmaceutical industry has been more interested in creating bilayer tablets over the past ten years as a way to improve patient compliance and convenience by combining two or more API in a single dose form.
{"title":"A Comprehensive Review on Floating Drug Delivery System","authors":"Pradnya D. Lahamge, Yashpal M. More, Pallavi P. Ahire, Vinay R. Kothawade","doi":"10.52711/0975-4377.2024.00007","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00007","url":null,"abstract":"The category of gastroretentive drug delivery systems (GRDDS) includes floating drug delivery systems (FDDS). These dose formulations are intended to extend the duration of the stomach's residence period by a sustained release technique. Drugs which are harder to dissolve in high pH environments have improved bioavailability and solubility when incorporated into GRDDS. Reduced intestinal absorption of solid dose forms can be accomplished by the flotation mechanism. The novel fusion of bilayer and floating mechanism is demonstrated by the bilayer floating drug delivery device. It demonstrates the effective creation of a controlled release formulation. Bilayer floating tablets offer a sustained release layer formulation in addition to an immediate release. A attempt was made to explain the mechanism of FDDS, or floating bilayer, in the review. In order to accomplish regulated administration of various medications with predetermined release profiles, bi-layer tablets were developed. The pharmaceutical industry has been more interested in creating bilayer tablets over the past ten years as a way to improve patient compliance and convenience by combining two or more API in a single dose form.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00015
Muskan Rathor, Anshika Garg
Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.
{"title":"Gastroretentive drug delivery system: An Overview","authors":"Muskan Rathor, Anshika Garg","doi":"10.52711/0975-4377.2024.00015","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00015","url":null,"abstract":"Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00016
Navdeep Singh, S. Sweta, Shammy Jindal
Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to tackle such issues. Fast dissolving films were invented for the patients who have swallowing issues with conventional/traditional oral solid dosage forms. They also have a quick onset of effect, taking only a few seconds, because the drug is absorbed directly from the injection site to the systemic circulation, avoiding first-pass metabolism. In the preparation of films, polymers, surfactants, flavoring agents, coloring agents, sweetening agents, saliva stimulating agents, drug, and plasticizer are used. The drug incorporated in ODF should have pleasing taste, low molecular weight, high stability, and high aqueous solubility. Solvent and semisolid casting, hot melt extrusion, and rolling techniques are routinely used to prepare ODFs. Thickness, loss on drying, tensile strength, and elongation percentage are commonly assessed for evaluating ODFs, as well as their resistance to tearing, weight variation, folding endurance, pH, swelling property, transparency, disintegration, dissolution rate, and stability. The purpose of this review article is to provide a quick overview of ODF delivery systems.
{"title":"A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s","authors":"Navdeep Singh, S. Sweta, Shammy Jindal","doi":"10.52711/0975-4377.2024.00016","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00016","url":null,"abstract":"Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to tackle such issues. Fast dissolving films were invented for the patients who have swallowing issues with conventional/traditional oral solid dosage forms. They also have a quick onset of effect, taking only a few seconds, because the drug is absorbed directly from the injection site to the systemic circulation, avoiding first-pass metabolism. In the preparation of films, polymers, surfactants, flavoring agents, coloring agents, sweetening agents, saliva stimulating agents, drug, and plasticizer are used. The drug incorporated in ODF should have pleasing taste, low molecular weight, high stability, and high aqueous solubility. Solvent and semisolid casting, hot melt extrusion, and rolling techniques are routinely used to prepare ODFs. Thickness, loss on drying, tensile strength, and elongation percentage are commonly assessed for evaluating ODFs, as well as their resistance to tearing, weight variation, folding endurance, pH, swelling property, transparency, disintegration, dissolution rate, and stability. The purpose of this review article is to provide a quick overview of ODF delivery systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00013
Nikhil Rathore, Abhishek Taiger, Suruchi Prasad
Allergies, is a bunch of medical circumstances caused by the hypersensitivity of the immune system to typically harmless substances in the environment. Allergy can be a type of hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms of allergy include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Antihistaminics are very useful candidates to treat allergy. The dose of antihistaminics can be reduced by local administration of anti-histaminics at the site of allergy. Skin allergy is basically related to dermal site of the skin it replicates to other organ near or in contact with skin. Administration of chlorpheniramine directly to the shin as topical drug delivery system will help to reduce the skin allergies.
{"title":"A Review on Effective Treatment of Chronic Skin Allergy using Chlorpheniramine","authors":"Nikhil Rathore, Abhishek Taiger, Suruchi Prasad","doi":"10.52711/0975-4377.2024.00013","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00013","url":null,"abstract":"Allergies, is a bunch of medical circumstances caused by the hypersensitivity of the immune system to typically harmless substances in the environment. Allergy can be a type of hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms of allergy include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Antihistaminics are very useful candidates to treat allergy. The dose of antihistaminics can be reduced by local administration of anti-histaminics at the site of allergy. Skin allergy is basically related to dermal site of the skin it replicates to other organ near or in contact with skin. Administration of chlorpheniramine directly to the shin as topical drug delivery system will help to reduce the skin allergies.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00004
D. Sunitha, M. Sudhakar, G. Abhigna, G. Deevena, J. Deekshitha, J. Swapna, J. Shreya
Dentifrices are the products which are used for oral hygiene such as freshness of mouth and to avoid tooth decay. The oral hygiene can be maintained throughout the day by using various dentifrices prepared by herbal and synthetic ingredients. In present study the toothpaste was prepared by using various herbal ingredients which possess antibacterial, antiseptic and cooling properties.
{"title":"Formulation and Evaluation of Herbal Toothpaste","authors":"D. Sunitha, M. Sudhakar, G. Abhigna, G. Deevena, J. Deekshitha, J. Swapna, J. Shreya","doi":"10.52711/0975-4377.2024.00004","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00004","url":null,"abstract":"Dentifrices are the products which are used for oral hygiene such as freshness of mouth and to avoid tooth decay. The oral hygiene can be maintained throughout the day by using various dentifrices prepared by herbal and synthetic ingredients. In present study the toothpaste was prepared by using various herbal ingredients which possess antibacterial, antiseptic and cooling properties.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00008
Vinay R. Kothawade, Yashpal M. More, Pradnya D. Lahamge, Pallavi P. Ahire
When the high cardiac output exerts pressure on the arterial wall as blood flow increases, hypertension, or high blood pressure, occurs. Bi-layer tablets consists with one layer of the drug prepared for immediate release or a second layer intended for sustained release, these can be used as an sustained release method or as a second dose. A bi-layered tablet is used to break away two chemicals that are incompatible, release both drugs continually in combination, or create a sustained release tablet with an initial dose that is released immediately and a maintenance dose that is granted as with time. Bilayer tablets can be used for sustained release tablets, where the first layer is immediate release as the initial dose and the second layer is delayed release. It can also be used for the sequential release of two drugs combination or at separate two incompatible items.
{"title":"Recent Advances on Bilayer Tablet","authors":"Vinay R. Kothawade, Yashpal M. More, Pradnya D. Lahamge, Pallavi P. Ahire","doi":"10.52711/0975-4377.2024.00008","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00008","url":null,"abstract":"When the high cardiac output exerts pressure on the arterial wall as blood flow increases, hypertension, or high blood pressure, occurs. Bi-layer tablets consists with one layer of the drug prepared for immediate release or a second layer intended for sustained release, these can be used as an sustained release method or as a second dose. A bi-layered tablet is used to break away two chemicals that are incompatible, release both drugs continually in combination, or create a sustained release tablet with an initial dose that is released immediately and a maintenance dose that is granted as with time. Bilayer tablets can be used for sustained release tablets, where the first layer is immediate release as the initial dose and the second layer is delayed release. It can also be used for the sequential release of two drugs combination or at separate two incompatible items.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present work was the preparation and optimization of mouth-dissolving tablets (MDTs) of Ivabradine hydrochloride by using natural super disintegrants. The tablets were prepared using microcrystalline cellulose as diluent and aspartame as a sweetening agent along with Natural super disintegrants. The natural super disintegrants used in this study were Guar Gum and Banana powder. By using natural superdisintegrants we had saved the environment and protected our bodies from the harmful effect of synthetic superdisintegrants. The tablet was prepared by the direct compression method. The 6mm of punch was used and the tablet weight is 110 mg. The tablets were evaluated for weight variation, hardness, friability, wetting time, disintegration time (DT), and dissolution study. Different concentration of superdisintegrants was used in this formulation as 6%, 8%, and 10%. The three batches of guar gum and 3 batches of banana powder were prepared i.e., a Total of six batches were prepared. From the results obtained, it can be concluded that the tablet formulation prepared with 10% banana powder i.e., 10 mg showed fast and higher drug release (98.66%) during in vitro dissolution study. Also, the hardness, friability, dissolution rate, and assay of prepared tablets (batch F6) were found to be acceptable according to standard limits. The result was the F6 batch was optimized batch from all the batches.
{"title":"Preparation and Optimization of Ivabradine Hydrochloride Mouth-Dissolving Tablet","authors":"Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain","doi":"10.52711/0975-4377.2023.00040","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00040","url":null,"abstract":"The aim of the present work was the preparation and optimization of mouth-dissolving tablets (MDTs) of Ivabradine hydrochloride by using natural super disintegrants. The tablets were prepared using microcrystalline cellulose as diluent and aspartame as a sweetening agent along with Natural super disintegrants. The natural super disintegrants used in this study were Guar Gum and Banana powder. By using natural superdisintegrants we had saved the environment and protected our bodies from the harmful effect of synthetic superdisintegrants. The tablet was prepared by the direct compression method. The 6mm of punch was used and the tablet weight is 110 mg. The tablets were evaluated for weight variation, hardness, friability, wetting time, disintegration time (DT), and dissolution study. Different concentration of superdisintegrants was used in this formulation as 6%, 8%, and 10%. The three batches of guar gum and 3 batches of banana powder were prepared i.e., a Total of six batches were prepared. From the results obtained, it can be concluded that the tablet formulation prepared with 10% banana powder i.e., 10 mg showed fast and higher drug release (98.66%) during in vitro dissolution study. Also, the hardness, friability, dissolution rate, and assay of prepared tablets (batch F6) were found to be acceptable according to standard limits. The result was the F6 batch was optimized batch from all the batches.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.52711/0975-4377.2023.00046
Pratik B. Dandare, Puja. N. Gayke, Ankush B. Thorat, Aniket. R. Pawar, Sandip P. Narale, Prathamesh M. Bhadane, Priynka. M. Salve, B. M. Narwate
Hair plays a very important role in the personality of humans and for their cure by using lots of cosmetic products. Herbal formulations always have activity and comparatively lesser or no side effects with synthetic. Hair formulation of Embica officinalis (Fruits), Bacopa monnieri (Leaves), Trigonella foenum graecum (Seeds), Murraya koenigii (Leaf), Hibiscus rosasinensis (Flowers) in different concentrations in the form of herbal oil were studied for their hair growth activity, refractive index, acid value, saponification value.. Admirable results of hair growth were seen in formulation prepared by different methods of oils preparation technique.
{"title":"Nourishing Hair Oil","authors":"Pratik B. Dandare, Puja. N. Gayke, Ankush B. Thorat, Aniket. R. Pawar, Sandip P. Narale, Prathamesh M. Bhadane, Priynka. M. Salve, B. M. Narwate","doi":"10.52711/0975-4377.2023.00046","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00046","url":null,"abstract":"Hair plays a very important role in the personality of humans and for their cure by using lots of cosmetic products. Herbal formulations always have activity and comparatively lesser or no side effects with synthetic. Hair formulation of Embica officinalis (Fruits), Bacopa monnieri (Leaves), Trigonella foenum graecum (Seeds), Murraya koenigii (Leaf), Hibiscus rosasinensis (Flowers) in different concentrations in the form of herbal oil were studied for their hair growth activity, refractive index, acid value, saponification value.. Admirable results of hair growth were seen in formulation prepared by different methods of oils preparation technique.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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