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Optimization of Secure Workstation for manipulation of 35S-labelled molecules: a case of in vitro cell metabolic labelling 操作35s标记分子的安全工作站的优化:体外细胞代谢标记的一个案例
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-04-25 DOI: 10.1051/radiopro/2023015
M. Audry, M. Coureuil, A. Hinzpeter, P. Frot, O. Saltiel, M. Kadri, M-L Gaab, A-S Armand, N. Servel
Pulse-chase or cell metabolic experiments involving 35S labelled molecules are deemed to be volatile. Neither the suppliers nor the literature propose any solutions to limit contamination. The aim of this study is to fill in this gap. Here, we expose the usual procedures, which consist in working with the available equipment. As this procedure leads to internal and external contaminations of the operators, we tested a more secure workstation with collective protection equipment that we validated as limiting contaminations for workers. This study proposes a method to use 35S labelled molecules in a more secure way, which could be applied in any laboratory.
涉及35S标记分子的脉冲追踪或细胞代谢实验被认为是挥发性的。供应商和文献都没有提出任何限制污染的解决方案。本研究的目的就是填补这一空白。在这里,我们暴露了通常的程序,包括使用可用的设备。由于该程序会导致操作人员的内部和外部污染,我们测试了一个更安全的工作站,配备了集体保护设备,我们验证了该设备可以限制工人的污染。本研究提出了一种以更安全的方式使用35S标记分子的方法,可应用于任何实验室。
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引用次数: 0
An analysis of the desire to make radiation measurements and to dialogue with experts among the residents of Tomioka town, Fukushima Prefecture: about the implementation of the co-expertise process 对福岛县富冈镇居民进行辐射测量和与专家对话的愿望的分析:关于共同专业知识进程的实施
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-04-01 DOI: 10.1051/radiopro/2022035
W. Thu Zar, H. Matsunaga, X. Xiao, J. Lochard, M. Orita, N. Takamura
The article presents a contribution concerning the desire to make radiation measurements and to dialogue with experts among the residents of Tomioka town close to the Fukushima Daiichi Nuclear Power Plant in Japan at the time of the lifting of the relocation order in 2017. Relying on data from a questionnaire conducted at the same time with approximately 8000 residents aged 20 years or older who lived in Tomioka before the accident, a logistic regression analysis was performed to identify retrospectively the factors having driven these desires. The results shed some light on the motivation of affected people to engage in the co-expertise process implemented in Tomioka by experts from Nagasaki University and local authorities. In essence there are two significant results: (i) the people who have the desire to make radiation measurements are those who are reluctant to eat foods produced in the town and who already had an experience of radiation measurement, (ii) the people who have the desire to dialogue with experts about radiation exposure and health effects are above 60 years old and are reluctant to eat foods produced in the town and to drink tap water. In both cases people can imagine living in Tomioka now and in the future. Perspectives regarding future research are envisaged.
本文介绍了在2017年解除搬迁令时,日本福岛第一核电站附近富冈镇居民进行辐射测量和与专家对话的愿望。根据同时对事故发生前居住在富冈市的约8000名20岁或以上居民进行的问卷调查的数据,进行了逻辑回归分析,以回顾性地确定驱动这些愿望的因素。调查结果在一定程度上揭示了受影响民众参与由长崎大学和地方当局的专家在富冈实施的共同专业知识进程的动机。从本质上讲,有两个重要的结果:(i)希望进行辐射测量的人是那些不愿食用该镇生产的食品和已经有辐射测量经验的人;(ii)希望与专家就辐射照射和健康影响进行对话的人年龄在60岁以上,不愿食用该镇生产的食品和饮用自来水。在这两种情况下,人们都可以想象现在和未来生活在富冈。展望了未来研究的前景。
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引用次数: 1
Establishment of exposure levels for computed tomography examinations based on clinical indication, patient gender and size and the use of contrast in Lebanon. 在黎巴嫩,根据临床指征、病人性别和体型以及造影剂的使用确定计算机断层扫描检查的暴露水平。
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-03-31 DOI: 10.1051/radiopro/2023013
M. Rizk, Mrs. Hakme
This study aims to establish exposure levels for computed tomography (CT) examinations performed on adult patients based on clinical indication (CI), patient gender and size and the use of contrast in Lebanon. The volume CT dose index (CTDIvol), size-specific dose estimate (SSDE) and dose length product (DLP) were collected between January 2010 and December 2021 from 14 Lebanese hospitals. The data were collected from at least 20 patients for 15 common groups of CIs in the head, thorax, abdomen (AB), abdomen-pelvis (ABP) and thorax-abdomen-pelvis (TABP) regions. The exposure levels were calculated for each group of CIs, patient gender and size and depending on the use of contrast as the third quartile of the CT scanners’ median values of CTDIvol, SSDE and DLP. The exposure levels in term of CTDIvol (DLP) were 65, 15, 9, 9 and 12 mGy (1105, 483, 522, 440 and 610 mGy.cm), respectively, for Head/Hemorrhage, ABP/Appendicitis, AB/Abdominal pain, Thorax/Covid-19 and TABP/Trauma. Median DLP values for male, large size patients and those administered with contrast were significantly higher (p<0.05) than those from female, medium size patients and those without contrast media, respectively, for all the groups of CIs in the thorax, AB, ABP and TABP regions. The established exposure levels were higher than those from the literature pointing up the need for a dose optimization strategy to protect the patient from the harmful effects of radiation.
本研究旨在根据黎巴嫩的临床指征(CI)、患者性别和体型以及造影剂的使用,确定对成年患者进行计算机断层扫描(CT)检查的暴露水平。2010年1月至2021年12月期间,从黎巴嫩14家医院收集了体积CT剂量指数(CTDIvol)、大小特异性剂量估计值(SSDE)和剂量长度乘积(DLP)。数据收集自至少20例患者,包括头、胸、腹(AB)、腹-盆(ABP)和胸腹-盆(TABP)区域15组常见的CIs。根据CT扫描仪CTDIvol、SSDE和DLP中位数的第三个四分位数使用造影剂,计算每组ci、患者性别和体型的暴露水平。头部/出血、ABP/阑尾炎、AB/腹痛、胸腔/Covid-19和TABP/创伤的CTDIvol (DLP)暴露水平分别为65、15、9、9和12 mGy(1105、483、522、440和610 mGy.cm)。在胸部、AB、ABP和TABP区域的所有ci组中,男性、大尺寸患者和使用造影剂的患者的中位DLP值分别显著高于女性、中尺寸患者和未使用造影剂的患者(p<0.05)。已确定的照射水平高于文献中的水平,这表明需要制定剂量优化策略,以保护患者免受辐射的有害影响。
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引用次数: 0
Proposal of a quantitative approach integrating radioactive and chemical risks 提出综合放射性和化学风险的定量方法
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-03-15 DOI: 10.1051/radiopro/2023012
L. Vaillant, M. Maître, E. Lafranque, T. Schneider, V. Wasselin
A number of situations lead to risks associated with both radionuclides and chemicals exposures: management of contaminated sites, NORM industries, management of indoor air quality, occupational risks, etc. Risk assessment and risk management associated with chemical and radioactive substances are based on different approaches and risk metrics, making it possibly hard to compare those risks and to manage risks in a commensurate way. This article presents a method to express health risk using a common metric, the DALY (Disability-Adjusted Life Year), which is used among others by WHO to guide public health policies. The proposed approach, allowing for comparison, hierarchy and aggregation of risks associated with exposure to ionizing radiations and chemical substances, can support communication and dialog between stakeholders on complex situations.
一些情况导致与放射性核素和化学品接触有关的风险:受污染场地的管理、规范工业、室内空气质量管理、职业风险等。与化学和放射性物质有关的风险评估和风险管理基于不同的方法和风险指标,因此可能难以比较这些风险并以相称的方式管理风险。本文提出了一种使用残疾调整生命年(DALY)这一常用指标来表达健康风险的方法,该指标除其他外被世卫组织用于指导公共卫生政策。拟议的方法允许对电离辐射和化学物质暴露相关的风险进行比较、分层和汇总,可以支持利益攸关方之间就复杂情况进行沟通和对话。
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引用次数: 2
Assessment of entrance skin dose for adult patients undergoing diagnostic X-ray Examinations in the Souss Massa Region of Morocco 评估摩洛哥苏马萨地区接受诊断性x射线检查的成年患者的入口皮肤剂量
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-03-09 DOI: 10.1051/radiopro/2023011
M. El Fahssi, S. Semghouli, B. Amaoui, L. Jroundi, M. ÇAOUI
The objective of this study is to evaluate entrance skin doses, and to establish the diagnostic reference levels for the most common x-ray examinations in adult patients in the Souss Massa region of Morocco. Data from 720 adult patients in four radiology departments in the Souss Massa region were collected. The data concerned the following examinations: Thorax posterior anterior (PA), unprepared abdominal x-ray, pelvis, hip, cervical spine anterior-posterior (AP) and lateral (Lat), lumbar spine anterior-posterior (AP) and lateral (Lat). The following parameters were reported for each examination: Age, weight, patient thickness, voltage (kV), electrical charge (mAs), and the skin source distance. The Entrance Skin Dose (ESD) and the Diagnostic Reference Levels (DRL) are calculated for each X-ray examination. DRLs in terms of ESD for the same x-ray examination differ widely from one hospital to another. They ranged from 3 to 14 mGy for the unprepared abdominal x-ray, from 2.6 to 9.4 mGy for the pelvis, from 3.1 to 17 mGy for the hip, from 1 to 49.2 mGy for the cervical spine Lat, from 2 to 32.6 mGy for the lumbar spine AP, and from 18.1 to 50 mGy for the lumbar spine Lat. The variation of doses received by patients in the four hospitals calls into question radiological procedures and practices and calls for a standardization of guidelines for each radiological examination.
本研究的目的是评估入口皮肤剂量,并为摩洛哥Souss Massa地区成年患者最常见的x射线检查建立诊断参考水平。收集了苏马萨地区四个放射科720名成年患者的数据。数据涉及以下检查:胸后前位(PA),未准备腹部x线片,骨盆,髋关节,颈椎前后位(AP)和侧位(Lat),腰椎前后位(AP)和侧位(Lat)。每次检查报告以下参数:年龄、体重、患者厚度、电压(kV)、电荷(mAs)和皮肤源距离。每次x光检查均计算皮肤入口剂量(ESD)和诊断参考水平(DRL)。在同一x线检查中,不同医院在ESD方面的drl差异很大。未准备腹部x线检查为3至14 mGy,骨盆为2.6至9.4 mGy,髋关节为3.1至17 mGy,颈椎Lat检查为1至49.2 mGy,腰椎AP检查为2至32.6 mGy,腰椎Lat检查为18.1至50 mGy。这四家医院的病人所接受剂量的变化使人们对放射治疗程序和做法提出质疑,并要求对每次放射检查的指导方针进行标准化。
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引用次数: 1
Mathematical Formula to Calculate the Attenuation Coefficients for Any Complex Sample: Experimental Study 计算任何复杂样品衰减系数的数学公式:实验研究
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-02-28 DOI: 10.1051/radiopro/2023010
M. M. Gouda, M. Abbas, Ali O. Ismail, A. El-Khatib
This work introduces a mathematical formula to calculate the attenuation coefficient of a cylindrical sample placed on the top of a well-shaped gamma-ray detector. The formula depends on calculations of the average path length of the photon through a sample and the effective solid angle. The obtained results using the introduced formula are compared with the NIST XCOM database and also compared with the experimental work using two different-sized detectors and sources located in two different positions. A remarkable agreement between both was observed, which proves the validity of this formula.
本文介绍了一个计算放置在形状良好的伽玛射线探测器顶部的圆柱形样品衰减系数的数学公式。该公式依赖于光子通过样品的平均路径长度和有效立体角的计算。利用引入的公式得到的结果与NIST XCOM数据库进行了比较,并与两个不同尺寸的探测器和两个不同位置的源的实验结果进行了比较。两者之间有显著的一致性,证明了公式的有效性。
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引用次数: 0
Effect of new radioprotective equipment on decreasing radiation of participants in percutaneous coronary interventional procedure 新型放射防护设备对经皮冠状动脉介入手术参与者降低辐射的影响
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-02-28 DOI: 10.1051/radiopro/2023009
F. Liu, Raja, Z. You, J. Wang, W. Li, Y. Wu, W. Suthakorn, L. Liao
Background: The hazard of ionizing radiation to medical staff in Percutaneous Coronary Interventional procedure (PCI) is the largest among all interventional procedures and increasing, this phenomenon has received the attention of researchers in various countries. Radiation protective shielding equipment is an accepted effective measure, but protective performance is associated with poor applicability for diverse interventional procedures. The aim of this study attempted to develop new radioprotective shielding equipment for PCI and measure its effectiveness and applicability. Methods: This study established a radioprotective cabin for PCI and used fluoroscopy and cine modes of DSA machine to compare the effectiveness between the experimental group (radioprotective cabin) and control group (current normal radioprotection). A 231 radiation intensity data collected, dots were set around the standardized patient, 210 points were distributed on the vertical plane around the therapy bed, and 21 points were evenly distributed in the patient's thyroid, head, and gonadal area. Results: Based on cine modes, there were statistically significant differences between the 2 groups of the radiation intensities in the left plane, right plane, foot plane, head and face area, and the gonads area (Z=-6.645, -5.615, -6.204, -2.647, -2.882, P<0.05). Based on fluoroscopy modes, there were statistically significant differences between 2 groups of the radiation intensities in the left plane, right plane, foot plane, and gonads area (Z=-6.060, -5.083, -5.203, -2.887, P<0.05) Conclusion: The radioprotective cabin can effectively reduce the radiation intensity in the routine standing area and radiation-sensitive areas of the patient without affecting the operation, which can be strongly promoted in PCI procedure.
背景:经皮冠状动脉介入手术(PCI)中电离辐射对医务人员的危害是所有介入手术中最大的,且危害越来越大,这一现象已受到各国研究者的重视。辐射防护屏蔽设备是一种公认的有效措施,但其防护性能与各种介入程序适用性差有关。本研究的目的是尝试开发一种新型的PCI放射防护屏蔽设备,并测量其有效性和适用性。方法:本研究建立PCI放射防护舱,采用DSA机透视和cine模式,比较实验组(放射防护舱)与对照组(当前正常放射防护)的有效性。收集231个辐射强度数据,在标准化患者周围设置点,210个点分布在治疗床周围的垂直线上,21个点均匀分布在患者的甲状腺、头部和性腺区。结果:基于影像模式,两组患者左、右、足、头面、性腺区域辐射强度比较,差异均有统计学意义(Z=-6.645, -5.615, -6.204, -2.647, -2.882, P<0.05)。基于透视模式,两组患者左、右、足、性腺区域的辐射强度差异有统计学意义(Z=-6.060, -5.083, -5.203, -2.887, P<0.05)结论:放射防护舱可在不影响手术的情况下有效降低患者常规站立区及辐射敏感区辐射强度,在PCI手术中可得到大力推广。
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引用次数: 0
Dose assessment assisted by short-ranged computer simulation in a radioactive release event 在放射性释放事件中用短期计算机模拟辅助的剂量评估
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-02-28 DOI: 10.1051/radiopro/2023008
E. Ramos De Andrade
This study describes the computational modeling of the atmospheric dispersion of radionuclides resulting from a hypothetical nuclear accident involving an off-site release of the inventory of a Small Modular Reactor (SMR). The inventory released was simulated with the aid of the SCALE software, considering 2 years of continuous operation. The radionuclide Cs-137 was selected due to its abilities to cause environmental damage. A simulation of the atmospheric dispersion of the radionuclide was performed using the codes HotSpot (analytical) and ANSYS (numerical). The distribution of concentrations and consequent equivalent total effective doses (TEDE) were estimated as a function of the distance from the point of release and the local atmospheric stability conditions. In the study, a hybrid computer simulation refers to the simultaneous application of the analytical and numerical models of the nuclear event. The results from the simulated conditions agree with the environmental Cs-137 concentration values, regardless of whether those values are from a numerical or analytical model. However, there is a disagreement about the location and distribution of these concentrations. It was also verified that the average percentage error of the results obtained in the two simulations was around 5%, considering the evaluation between 400 and 1,500 m from the origin of the dispersion. For smaller distances in relation to the release point, the analytical and numerical models produce solutions that, although divergent, were shown to be complementary. The relevance of this investigation shows the importance of the convergence of isolated computing platforms in order to support decision-making.
本研究描述了一个假想的核事故所导致的放射性核素大气扩散的计算模型,该事故涉及小型模块化反应堆(SMR)库存的场外释放。考虑到连续经营2年,利用SCALE软件对库存释放情况进行模拟。选择放射性核素Cs-137是因为它有破坏环境的能力。利用HotSpot(解析)和ANSYS(数值)软件对放射性核素在大气中的扩散进行了模拟。浓度分布和相应的等效总有效剂量(TEDE)作为离释放点的距离和当地大气稳定性条件的函数进行了估计。在本研究中,混合计算机模拟是指同时应用核事件的解析模型和数值模型。模拟条件下的结果与环境Cs-137浓度值一致,无论这些值是来自数值还是解析模型。然而,对这些浓度的位置和分布存在分歧。考虑到距离色散原点400 ~ 1500 m的评估,验证了两次模拟结果的平均百分比误差在5%左右。对于相对于释放点的较小距离,分析模型和数值模型产生的解虽然不同,但证明是互补的。这项调查的相关性表明,为了支持决策,孤立的计算平台的融合非常重要。
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引用次数: 0
Radioprotection adopte le modèle « Subscribe-to-Open » de publication en open access Radioprotection采用“订阅-开放”模式开放获取
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-02-06 DOI: 10.1051/radiopro/2023007
Michel Bourguignon, Jean-Marc Bertho
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引用次数: 0
Chaleureux remerciements à nos relecteurs 衷心感谢我们的审稿人
IF 1.1 4区 医学 Q2 Energy Pub Date : 2023-01-23 DOI: 10.1051/radiopro/2023006
Jean-Marc Bertho
{"title":"Chaleureux remerciements à nos relecteurs","authors":"Jean-Marc Bertho","doi":"10.1051/radiopro/2023006","DOIUrl":"https://doi.org/10.1051/radiopro/2023006","url":null,"abstract":"","PeriodicalId":21009,"journal":{"name":"Radioprotection","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76187934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Radioprotection
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