Lens culinaris is an annual edible legume while Brassica napus is a common oil-production crop. One of the most frequent abiotic stresses endangering agricultural food crops is drought. Drought significantly impairs crop plants’ physiology and productivity which eventually results in plant death. The present research was done to ameliorate the adverse effects of drought stress on the growth, photosynthetic pigments and water status of Brassica napus L. (GSC-7 variety) and Lens culinaris (L.) Medikus (HM-1 variety) intercropping by combined application of potassium and farm yard manure (FYM). The treatments were given as control (2 irrigations), early irrigation (irrigation only during vegetative stage), late irrigation (irrigation only during flowering stage) and stress (0 irrigation) along with different concentrations of potassium and FYM i.e. K0(control) K1(10kg/acre) and K2(20kg/acre) K1M (10kg/acre+10tonne/hectare) and K2M (20kg/acre+10tonne/hectare. At the vegetative stage (45DAS), samples were taken and analyzed for different attributes. Drought stress significantly affected the morphology and physiology of both cultivars by reducing the photosynthetic pigments, water status (relative water content [RWC] and membrane stability index [MSI]) in both cultivars compared to the control. But potassium(K) and FYM supplementation improved both cultivars' RWC, MSI, photosynthetic pigments and growth parameters. In addition, after K and FYM application under drought stress, MDA levels and electrolyte leakage were decreased. These results authenticate that potassium in combination with FYM considerably reduces the effect of drought on both cultivars of intercropping by enhancing the plants' growth, photosynthetic activities and water status.
{"title":"Amelioration of water deficit by application of potassium and FYM in Lens culinaris (L.) Medikus and Brassica napus L. under intercropping system","authors":"Shweta Punia, Meenakshi Meenakshi, Narender Singh","doi":"10.25303/281rjce980106","DOIUrl":"https://doi.org/10.25303/281rjce980106","url":null,"abstract":"Lens culinaris is an annual edible legume while Brassica napus is a common oil-production crop. One of the most frequent abiotic stresses endangering agricultural food crops is drought. Drought significantly impairs crop plants’ physiology and productivity which eventually results in plant death. The present research was done to ameliorate the adverse effects of drought stress on the growth, photosynthetic pigments and water status of Brassica napus L. (GSC-7 variety) and Lens culinaris (L.) Medikus (HM-1 variety) intercropping by combined application of potassium and farm yard manure (FYM). The treatments were given as control (2 irrigations), early irrigation (irrigation only during vegetative stage), late irrigation (irrigation only during flowering stage) and stress (0 irrigation) along with different concentrations of potassium and FYM i.e. K0(control) K1(10kg/acre) and K2(20kg/acre) K1M (10kg/acre+10tonne/hectare) and K2M (20kg/acre+10tonne/hectare. At the vegetative stage (45DAS), samples were taken and analyzed for different attributes. Drought stress significantly affected the morphology and physiology of both cultivars by reducing the photosynthetic pigments, water status (relative water content [RWC] and membrane stability index [MSI]) in both cultivars compared to the control. But potassium(K) and FYM supplementation improved both cultivars' RWC, MSI, photosynthetic pigments and growth parameters. In addition, after K and FYM application under drought stress, MDA levels and electrolyte leakage were decreased. These results authenticate that potassium in combination with FYM considerably reduces the effect of drought on both cultivars of intercropping by enhancing the plants' growth, photosynthetic activities and water status.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of novel triazole functionalized trifluoromethyl pyridine derivatives was prepared starting from pyridine 1. Compound 1 on reaction with sulphuric acid gave compound 2 which on chlorination followed by hydrazine hydrate and obtained compound 3 and 4. Compound 4 on reaction with diverse substituted aliphatic and aromatic acid chlorides produced amide derivatives 4a-h and 5a-h. All the final compounds were evaluated for anti cancer activity against four human cancer cell lines such as HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22). Promising compounds 4f and 4g were identified.
{"title":"Novel triazolo pyridine derivatives and their anti cancer activity","authors":"Swamy M. Kumara, K. Bhaskar","doi":"10.25303/281rjce21026","DOIUrl":"https://doi.org/10.25303/281rjce21026","url":null,"abstract":"A series of novel triazole functionalized trifluoromethyl pyridine derivatives was prepared starting from pyridine 1. Compound 1 on reaction with sulphuric acid gave compound 2 which on chlorination followed by hydrazine hydrate and obtained compound 3 and 4. Compound 4 on reaction with diverse substituted aliphatic and aromatic acid chlorides produced amide derivatives 4a-h and 5a-h. All the final compounds were evaluated for anti cancer activity against four human cancer cell lines such as HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22). Promising compounds 4f and 4g were identified.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present study, a series of mesoionic pyrimidinium betaines obtained by condensation of α- -aminopyridine or N, N’- disubstituted amidines with substituted malonic esters was tested for in vitro antimicrobial activity against two bacteria: Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and three fungi: Aspergillus carbonarius, Fusarium culmorus and Mucor ramannianus to assess their potential use as antimicrobial agents using a well diffusion. These betaines are bicyclics 3, 4 monocyclic 6 and fatty betaine type of amphoteric surfactant 7. The synthesized compounds were found to exhibit moderate to high antifungal against the tested fungi. On the other hand, it was observed that most of the tested compounds revealed moderate antibacterial activity against Staphylococcus aureus while fatty chain betaine type amphoteric surfactant exhibited the best antibacterial activity. Whereas all compounds were found inactive against Gram-negative Escherichia coli. Investigation of antimicrobial activity of the synthesized compounds demonstrated that the meso-ionic nature of pyrimidinium betaines, the presence of the pyrimidine ring biologically active in their structure, the long hydrocarbon chain in fatty betaine and extended delocalization of electrons probably influenced the extent of antimicrobial activity and contributed to the remarkable inhibitory activity of these compounds. Based on these results, it can be assumed that pyrimidinium betaines could be useful in the development of new antimicrobial medicines and may be potential sources of new drugs effective against various infectious diseases.
{"title":"Synthesis of Heterocyclic Mesoionic Betaines Derivatives containing a Pyrimidine Ring for screening of their Biological Activities","authors":"F. Malki, Ali Alouache, Atika Meklat","doi":"10.25303/281rjce43047","DOIUrl":"https://doi.org/10.25303/281rjce43047","url":null,"abstract":"In the present study, a series of mesoionic pyrimidinium betaines obtained by condensation of α- -aminopyridine or N, N’- disubstituted amidines with substituted malonic esters was tested for in vitro antimicrobial activity against two bacteria: Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and three fungi: Aspergillus carbonarius, Fusarium culmorus and Mucor ramannianus to assess their potential use as antimicrobial agents using a well diffusion. These betaines are bicyclics 3, 4 monocyclic 6 and fatty betaine type of amphoteric surfactant 7. The synthesized compounds were found to exhibit moderate to high antifungal against the tested fungi. On the other hand, it was observed that most of the tested compounds revealed moderate antibacterial activity against Staphylococcus aureus while fatty chain betaine type amphoteric surfactant exhibited the best antibacterial activity. Whereas all compounds were found inactive against Gram-negative Escherichia coli. Investigation of antimicrobial activity of the synthesized compounds demonstrated that the meso-ionic nature of pyrimidinium betaines, the presence of the pyrimidine ring biologically active in their structure, the long hydrocarbon chain in fatty betaine and extended delocalization of electrons probably influenced the extent of antimicrobial activity and contributed to the remarkable inhibitory activity of these compounds. Based on these results, it can be assumed that pyrimidinium betaines could be useful in the development of new antimicrobial medicines and may be potential sources of new drugs effective against various infectious diseases.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138984814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.25303/2712rjce1230137
Nidhi Khare, Smarika Lawrence, Amita Chhatri
Lead is a heavy metal which affects all the systems of human body. An easy method for removal of lead contamination was developed by using graphene oxide coated sand particle (GOSC). In this study, GOSC was prepared using sand particle and sucrose solution under controlled heating program which shows efficient adsorption behavior compared to other adsorbents. GOSC offered very fast removal of Pb+2 with small amount of GOSC (0.09g) in 100 ppm adsorbate solution. Characterization of GOSC was done by using several advanced techniques like FTIR, XRD, SEM, EDX, TEM, DSC, and Zeta Potential measurements before and after adsorption of lead ion (Pb2+). Adsorption shows superiority over other methods because it involves effective and high removal efficiency adsorption (above 90%). Various parameters like the effect of time, pH, adsorbent, dose effect, concentration and temperature were studied. Various adsorption and kinetic models were also investigated using adsorption data and results showed that removal of lead (Pb2+) ion follows Langmuir isotherm (R2 = 99%), second order kinetics (R2 = 98%) and higher intraparticle diffusion (R2= 98%). The high percentage removal of metal ions with little quantity of GOSC confirmed that GOSC is an excellent, effective and economic adsorbent.
{"title":"Pb2+ ion removal from contaminated aqueous solution by adsorption onto Graphene Oxide Sand Composite (GOSC) for efficient water purification","authors":"Nidhi Khare, Smarika Lawrence, Amita Chhatri","doi":"10.25303/2712rjce1230137","DOIUrl":"https://doi.org/10.25303/2712rjce1230137","url":null,"abstract":"Lead is a heavy metal which affects all the systems of human body. An easy method for removal of lead contamination was developed by using graphene oxide coated sand particle (GOSC). In this study, GOSC was prepared using sand particle and sucrose solution under controlled heating program which shows efficient adsorption behavior compared to other adsorbents. GOSC offered very fast removal of Pb+2 with small amount of GOSC (0.09g) in 100 ppm adsorbate solution. Characterization of GOSC was done by using several advanced techniques like FTIR, XRD, SEM, EDX, TEM, DSC, and Zeta Potential measurements before and after adsorption of lead ion (Pb2+). Adsorption shows superiority over other methods because it involves effective and high removal efficiency adsorption (above 90%). Various parameters like the effect of time, pH, adsorbent, dose effect, concentration and temperature were studied. Various adsorption and kinetic models were also investigated using adsorption data and results showed that removal of lead (Pb2+) ion follows Langmuir isotherm (R2 = 99%), second order kinetics (R2 = 98%) and higher intraparticle diffusion (R2= 98%). The high percentage removal of metal ions with little quantity of GOSC confirmed that GOSC is an excellent, effective and economic adsorbent.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
South Sulawesi has potential in the development of bioethanol from biomass because it has a plantation sector which is a mainstay sector with various types of commodities that can produce biomass. One biomass that has the potential as a raw material for bioethanol is coconut pulp. The reason for choosing coconut pulp as raw material for bioethanol production is because the cellulose rate is 36.08%; hemicellulose is 12.58%, besides that coconut is the main commodity crop in the plantation sector in South Sulawesi and its utilization will not interfere with food needs so that it will ensure smooth production of bioethanol. This study aims to produce bioethanol with coconut pulp raw materials using physical pretreatment namely autoclave. Autoclave pretreatment results are followed by fermentation using yeast for 7, 9, 11, 13 and 15 days anaerobically and adding urea and NPK as nitrogen sources during the fermentation process. The result of fermentation was then distilled to obtain bioethanol for 12-72 hours. The highest bioethanol content was obtained after 13 days of fermentation which was 6,2683%. This pretreatment uses the influence of temperature and pressure to degrade lignin in coconut pulp to optimize fermentation results. Based on mapping the amount of coconut pulp, a coconut pulp supply network model can be produced at the upstream level including supply sources, depots and bioethanol plants.
{"title":"Utilization of Coconut Pulp as Raw Material for Bioethanol Production","authors":"Sariwahyuni, Junianti Fitri, Indah Lestari Rianti","doi":"10.25303/2712rjce057063","DOIUrl":"https://doi.org/10.25303/2712rjce057063","url":null,"abstract":"South Sulawesi has potential in the development of bioethanol from biomass because it has a plantation sector which is a mainstay sector with various types of commodities that can produce biomass. One biomass that has the potential as a raw material for bioethanol is coconut pulp. The reason for choosing coconut pulp as raw material for bioethanol production is because the cellulose rate is 36.08%; hemicellulose is 12.58%, besides that coconut is the main commodity crop in the plantation sector in South Sulawesi and its utilization will not interfere with food needs so that it will ensure smooth production of bioethanol. This study aims to produce bioethanol with coconut pulp raw materials using physical pretreatment namely autoclave. Autoclave pretreatment results are followed by fermentation using yeast for 7, 9, 11, 13 and 15 days anaerobically and adding urea and NPK as nitrogen sources during the fermentation process. The result of fermentation was then distilled to obtain bioethanol for 12-72 hours. The highest bioethanol content was obtained after 13 days of fermentation which was 6,2683%. This pretreatment uses the influence of temperature and pressure to degrade lignin in coconut pulp to optimize fermentation results. Based on mapping the amount of coconut pulp, a coconut pulp supply network model can be produced at the upstream level including supply sources, depots and bioethanol plants.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present work, Bengal gram husk (BGH) of low cost, minimally pretreated and locally available abundant agricultural waste material was used as an adsorbent for removal of Hg2+ from aqueous media. The influence of several parameters like effect of pH, adsorbent dosage, initial metal concentration, contact time and presence of interfering ions were studied through batch adsorption studies. The adsorption models of Langmuir and Freundlich were used for for the calculation of isotherm constants. According to the Langmuir model, the maximum adsorption capacity of BGH for Hg (II) ions was found to be 51.85 mg/g. The presence of interfering ions like Mg, Ca, K and Na did not play a role in the removal of Hg (II) ions. The Hg (II) removal by BGH followed pseudo first order rate kinetics. The FTIR spectra and CHN analysis of BGH showed the presence of CH and CO groups on the surface of BGH, which played a significant role in removal of Hg (II). Desorption studies revealed that about 83% of the dye was desorbed at pH 2. The present work showed that the BGH can be applied to remove Hg (II) from wastewater.
在本研究中，孟加拉糙米壳（BGH）作为一种吸附剂被用于去除水介质中的 Hg2+，这种吸附剂成本低、预处理量少，而且当地有大量的农业废料。通过批量吸附研究，研究了几个参数的影响，如 pH 值、吸附剂用量、初始金属浓度、接触时间和干扰离子的存在。计算等温线常数时使用了 Langmuir 和 Freundlich 吸附模型。根据 Langmuir 模型，发现 BGH 对 Hg (II) 离子的最大吸附容量为 51.85 mg/g。Mg、Ca、K 和 Na 等干扰离子的存在对去除 Hg (II) 离子没有影响。BGH 对 Hg (II) 的去除遵循伪一阶速率动力学。BGH 的傅立叶变换红外光谱和 CHN 分析表明，BGH 表面存在 CH 和 CO 基团，它们在去除 Hg (II) 方面发挥了重要作用。解吸研究表明，在 pH 值为 2 时，约 83% 的染料被解吸。 本研究结果表明，BGH 可用于去除废水中的汞（II）。
{"title":"Removal of Mercury (II) ions from aqueous solution by adsorption on Cicer arientinum husk: Equilibrium, Kinetic and Mechanism Studies","authors":"Ahalya Naidu, Ravishankar Kanamadi, T.V. Ramachandra","doi":"10.25303/2712rjce024030","DOIUrl":"https://doi.org/10.25303/2712rjce024030","url":null,"abstract":"In the present work, Bengal gram husk (BGH) of low cost, minimally pretreated and locally available abundant agricultural waste material was used as an adsorbent for removal of Hg2+ from aqueous media. The influence of several parameters like effect of pH, adsorbent dosage, initial metal concentration, contact time and presence of interfering ions were studied through batch adsorption studies. The adsorption models of Langmuir and Freundlich were used for for the calculation of isotherm constants. According to the Langmuir model, the maximum adsorption capacity of BGH for Hg (II) ions was found to be 51.85 mg/g. The presence of interfering ions like Mg, Ca, K and Na did not play a role in the removal of Hg (II) ions. The Hg (II) removal by BGH followed pseudo first order rate kinetics. The FTIR spectra and CHN analysis of BGH showed the presence of CH and CO groups on the surface of BGH, which played a significant role in removal of Hg (II). Desorption studies revealed that about 83% of the dye was desorbed at pH 2. The present work showed that the BGH can be applied to remove Hg (II) from wastewater.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multi-component one-pot synthesis of biologically active heterocyclic compounds has been prevailing as a potential methodology to meet the therapeutic requirements of the pharmaceutical industry. On this background, a facile one-pot green synthesis of Nsubstitutedaryl- 2-(chloroquinoline)-4-thiazolidinone derivatives (4a-h) was conducted with a mixture of 2- chloroquinoline-3-carbaldehyde (1), thioglycolic acid (2) and various aromatic amines (3a-h). The reaction involved cyclo-condensation mechanism catalyzed by the synthesized CuO NPs which were obtained through hydrothermal method. These NPs were characterized by XRD, SEM-EDS, TEM and BET surface area instrumental techniques. Furthermore, the magnetic property of the CuO NPs was determined through hysteresis loop, and the specific magnetization (Ms) was obtained at 19.79 emu/g. The structural parts of the synthesized compounds were interpreted by 1H-NMR, 13C-NMR, FT-IR and Mass spectral techniques. The cytotoxic studies of the compounds were evaluated against cancer causing human cells like A431 (epidermoid carcinoma), A549 (human alveolar epithelial cell line), Colo-205 (human colon carcinoma) using Doxorubicin as the standard drug. In these studies, the compounds 4a (paramethoxyphenyl), 4b (para-hydroxyphenyl), 4d (metanitro), 4f (1, 3-dichlorophenyl), 4g (para-fluorophenyl) and 4h (3, 5-dimethylphenyl) have shown a prominent anti-cancer activity than the remaining compounds.
{"title":"Green Synthesis of N-Aryl, 2-(Chloroquinoline)-4-Thiazolidinone Derivatives using Magnetically Separable Copper Oxide Nano Particles and their Anti-Cancer Activity Studies","authors":"Vara Satish Sangula, P. Sanasi","doi":"10.25303/2712rjce012023","DOIUrl":"https://doi.org/10.25303/2712rjce012023","url":null,"abstract":"Multi-component one-pot synthesis of biologically active heterocyclic compounds has been prevailing as a potential methodology to meet the therapeutic requirements of the pharmaceutical industry. On this background, a facile one-pot green synthesis of Nsubstitutedaryl- 2-(chloroquinoline)-4-thiazolidinone derivatives (4a-h) was conducted with a mixture of 2- chloroquinoline-3-carbaldehyde (1), thioglycolic acid (2) and various aromatic amines (3a-h). The reaction involved cyclo-condensation mechanism catalyzed by the synthesized CuO NPs which were obtained through hydrothermal method. These NPs were characterized by XRD, SEM-EDS, TEM and BET surface area instrumental techniques. Furthermore, the magnetic property of the CuO NPs was determined through hysteresis loop, and the specific magnetization (Ms) was obtained at 19.79 emu/g. The structural parts of the synthesized compounds were interpreted by 1H-NMR, 13C-NMR, FT-IR and Mass spectral techniques. The cytotoxic studies of the compounds were evaluated against cancer causing human cells like A431 (epidermoid carcinoma), A549 (human alveolar epithelial cell line), Colo-205 (human colon carcinoma) using Doxorubicin as the standard drug. In these studies, the compounds 4a (paramethoxyphenyl), 4b (para-hydroxyphenyl), 4d (metanitro), 4f (1, 3-dichlorophenyl), 4g (para-fluorophenyl) and 4h (3, 5-dimethylphenyl) have shown a prominent anti-cancer activity than the remaining compounds.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.25303/2712rjce1110114
Dipti Shukla
Dicalcium magnesium disilicate (Ca2MgSi2O7) doped with cerium rare earth ions has been examined for its optical and photonic characteristics and applicability for radiation dosimetry applications. Mono-calcium aluminate that has cerium added to it, has been shown to be an excellent dosimeter with a linear response up to roughly 4 kGy of radiation exposures. Maximum TL emission is achieved at 4 mol% cerium dopant concentration. The clearly visible two peaks that were detected at 381.13K and 566.87K can be used as a high-temperature dosimetry advance. In this study, we reported the preparation technique and luminescence properties such as TL, ML, and PL of Ce3+ doped dicalcium magnesium silicate phosphors. The phosphors were prepared by the solid-state reaction method. The TL glow curves were recorded for all different concentrations of Ce- doped phosphors.
{"title":"Luminescence Properties of Ce-Doped Di-Calcium Magnesium Disilicate Ca2MgSi2O7:4 mol%Ce","authors":"Dipti Shukla","doi":"10.25303/2712rjce1110114","DOIUrl":"https://doi.org/10.25303/2712rjce1110114","url":null,"abstract":"Dicalcium magnesium disilicate (Ca2MgSi2O7) doped with cerium rare earth ions has been examined for its optical and photonic characteristics and applicability for radiation dosimetry applications. Mono-calcium aluminate that has cerium added to it, has been shown to be an excellent dosimeter with a linear response up to roughly 4 kGy of radiation exposures. Maximum TL emission is achieved at 4 mol% cerium dopant concentration. The clearly visible two peaks that were detected at 381.13K and 566.87K can be used as a high-temperature dosimetry advance. In this study, we reported the preparation technique and luminescence properties such as TL, ML, and PL of Ce3+ doped dicalcium magnesium silicate phosphors. The phosphors were prepared by the solid-state reaction method. The TL glow curves were recorded for all different concentrations of Ce- doped phosphors.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.25303/2712rjce1690179
Santosh Kumar Gandhi, B. Mandal
The current work identifies and characterises the stress degradation products of the anti-hypertensive drug sacubitril. The stability profile of sacubitril was evaluated under several stress settings including hydrolytic, oxidative, thermal and photolytic conditions in accordance with ICH recommendations. The degradation products of sacubitril were separated using reverse phase liquid chromatography and structural characterization was carried out using HRMS. The chromatographic separation was carried out by Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) using a Fortis C18 column (150 mm X 4.6 mm; 5μm particle size) with mobile phase A (consisting of 0.1% TFA in Milli-Q water) and mobile phase B (100% Acetonitrile) in gradient mode. With a sample injection volume of 10μL, the mobile phase flow rate was 0.7 mL/min. A quadrupole time-of-flight (Q-TOF) mass spectrometer was used for the LC-MS analysis. Sacubitril is relatively stable in oxidative, thermal and photolytic conditions; however, considerable degradation was observed in acid, base and neutral hydrolysis. Three degradation products were identified and the structural characterization of these impurities was performed using the HRMS data and mass fragmentation. The proposed RP-HPLC method was robust, precise and specific in determining the impurity profile of sacubitril under different stress conditions.
{"title":"Identification and Structural Characterization of Forced Degradation Impurities of Sacubitril by HRMS – Development and Validation of a Stability indicating RP-HPLC method","authors":"Santosh Kumar Gandhi, B. Mandal","doi":"10.25303/2712rjce1690179","DOIUrl":"https://doi.org/10.25303/2712rjce1690179","url":null,"abstract":"The current work identifies and characterises the stress degradation products of the anti-hypertensive drug sacubitril. The stability profile of sacubitril was evaluated under several stress settings including hydrolytic, oxidative, thermal and photolytic conditions in accordance with ICH recommendations. The degradation products of sacubitril were separated using reverse phase liquid chromatography and structural characterization was carried out using HRMS. The chromatographic separation was carried out by Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) using a Fortis C18 column (150 mm X 4.6 mm; 5μm particle size) with mobile phase A (consisting of 0.1% TFA in Milli-Q water) and mobile phase B (100% Acetonitrile) in gradient mode. With a sample injection volume of 10μL, the mobile phase flow rate was 0.7 mL/min. A quadrupole time-of-flight (Q-TOF) mass spectrometer was used for the LC-MS analysis. Sacubitril is relatively stable in oxidative, thermal and photolytic conditions; however, considerable degradation was observed in acid, base and neutral hydrolysis. Three degradation products were identified and the structural characterization of these impurities was performed using the HRMS data and mass fragmentation. The proposed RP-HPLC method was robust, precise and specific in determining the impurity profile of sacubitril under different stress conditions.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.25303/2712rjce1600168
Nishant Saxena, P. S. Chandrashekharaiah, Debanjan Sanyal, Ajit Sapre, Santanu Dasgupta
Urea is widely used in agriculture and aquaculture as a major source of nitrogenous fertilizer. Therefore, urea exists in dissolved form in the marine/freshwater ecosystem. However, if the concentration in waterbodies is higher than a threshold limit, it can be toxic to fish and prawns. Therefore, accurate measurement of urea is a must even in marine water systems. Estimation of urea from freshwater samples using colorimetric method is well established. The well-known diacetyl monoxime method is widely used for accurate estimation of urea from fresh water as well as various biological samples. The presence of various interfering ions in sea water affects the estimation and limits the adaptability of any new methods directly into sea water. The accurate and precise estimation of urea are essential to optimize the nutrient addition. In this study, the diacetyl monoxime method was considered for urea estimation in sea water (3.5% salinity) and the method was validated for specificity, linearity, robustness, ruggedness and sensitivity as per International Council for Harmonization guidelines. During this study, urea showed maximum absorbance at 524 nm wavelength in both the samples. This method was found linear up to 100 ppm of urea in fresh and sea water samples. The variations of wavelength by 5-10%, reagent volumes by 2.5-5%, sample storage, analysis did not show any significant impact on the estimation of urea from both the samples. However, the method was found more sensitive and showed the limit of detection of 0.5 ppm in fresh water and 1.5 ppm in sea water. The overall results indicate that this method is accurate and robust for sea water samples and therefore can be used for estimation of urea in sea water samples.
{"title":"Validation of Diacetyl Monoxime Method for Quantification of Urea in Sea Water","authors":"Nishant Saxena, P. S. Chandrashekharaiah, Debanjan Sanyal, Ajit Sapre, Santanu Dasgupta","doi":"10.25303/2712rjce1600168","DOIUrl":"https://doi.org/10.25303/2712rjce1600168","url":null,"abstract":"Urea is widely used in agriculture and aquaculture as a major source of nitrogenous fertilizer. Therefore, urea exists in dissolved form in the marine/freshwater ecosystem. However, if the concentration in waterbodies is higher than a threshold limit, it can be toxic to fish and prawns. Therefore, accurate measurement of urea is a must even in marine water systems. Estimation of urea from freshwater samples using colorimetric method is well established. The well-known diacetyl monoxime method is widely used for accurate estimation of urea from fresh water as well as various biological samples. The presence of various interfering ions in sea water affects the estimation and limits the adaptability of any new methods directly into sea water. The accurate and precise estimation of urea are essential to optimize the nutrient addition. In this study, the diacetyl monoxime method was considered for urea estimation in sea water (3.5% salinity) and the method was validated for specificity, linearity, robustness, ruggedness and sensitivity as per International Council for Harmonization guidelines. During this study, urea showed maximum absorbance at 524 nm wavelength in both the samples. This method was found linear up to 100 ppm of urea in fresh and sea water samples. The variations of wavelength by 5-10%, reagent volumes by 2.5-5%, sample storage, analysis did not show any significant impact on the estimation of urea from both the samples. However, the method was found more sensitive and showed the limit of detection of 0.5 ppm in fresh water and 1.5 ppm in sea water. The overall results indicate that this method is accurate and robust for sea water samples and therefore can be used for estimation of urea in sea water samples.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：