Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1628208
Monika, G. Rani, Naveen Kumar, R. Ahlawat
Advanced corrosion protection methods include covering stainless steel surfaces with conductive polymer-based coatings. Polypyrrole and polypyrrole composites of tungstate of different concentrations were deposited on stainless steel-304 using cyclic voltammetry and their elemental analysis was verified by EDX analysis. EIS and potentiodynamic polarization analysis show that the corrosion protection efficiency (CPE) of polypyrrole composites is higher than polypyrrole coating. The reduction in corrosion rate due to the inhibitory action of tungstate through the physical barrier and anodic protection mechanism was validated by greater Rct and lower Icorr values of polypyrrole composites. In the composites, with increasing the concentration of tungstate in polypyrrole from 5% to 15%, CPE also increases, as polypyrrole composites are more able to shift the corrosion potential of stainless steels towards the passive zone and form a new nonporous passive oxide film on the surface. With a 15% concentration coating, the highest CPE of 93% and the lowest corrosion rate of 130 mmpy were obtained, indicating that the entire stainless steel active surface area is completely absorbed and that no active sites exit for adsorption at this concentration. The synthesized polypyrrole composites with a 15% concentration offer excellent corrosion protection prospects.
{"title":"EVALUATION OF CORROSION PROTECTION CAPACITY OF DOPED PPY FILM FOR STAINLESS STEEL IN AN ACIDIC MEDIUM","authors":"Monika, G. Rani, Naveen Kumar, R. Ahlawat","doi":"10.31788/rjc.2023.1628208","DOIUrl":"https://doi.org/10.31788/rjc.2023.1628208","url":null,"abstract":"Advanced corrosion protection methods include covering stainless steel surfaces with conductive polymer-based coatings. Polypyrrole and polypyrrole composites of tungstate of different concentrations were deposited on stainless steel-304 using cyclic voltammetry and their elemental analysis was verified by EDX analysis. EIS and potentiodynamic polarization analysis show that the corrosion protection efficiency (CPE) of polypyrrole composites is higher than polypyrrole coating. The reduction in corrosion rate due to the inhibitory action of tungstate through the physical barrier and anodic protection mechanism was validated by greater Rct and lower Icorr values of polypyrrole composites. In the composites, with increasing the concentration of tungstate in polypyrrole from 5% to 15%, CPE also increases, as polypyrrole composites are more able to shift the corrosion potential of stainless steels towards the passive zone and form a new nonporous passive oxide film on the surface. With a 15% concentration coating, the highest CPE of 93% and the lowest corrosion rate of 130 mmpy were obtained, indicating that the entire stainless steel active surface area is completely absorbed and that no active sites exit for adsorption at this concentration. The synthesized polypyrrole composites with a 15% concentration offer excellent corrosion protection prospects.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1628362
K. Jayanthi, M. Sivaraju
Corrosion is a significant issue with metallic materials, notably in steel due to its extensive use in a variety of industries. Benzoxazine polymers have been used to produce anti-corrosive compounds that have a remarkable ability to limit corrosion. In the same ink line, we have explored a new approach with a very hydrophobic benzoxazine monomer which is co-polymerized with urethane, and its characterization was studied with IR, UV, and NMR techniques. The corrosion resistance of the same is investigated using Tafel polarization and EIS experiment methodologies. The DFT and MEP studies explain the reactivity towards the anti-corrosive properties of the monomer.
{"title":"SYNTHESIS AND CHARACTERIZATION OF BENZOXAZINE: URETHANE COPOLYMER FROM VANILLIN WITH ADAMANTANE SIDE CHAIN AND ITS ANTICORROSIVE COATING ON MILD STEEL","authors":"K. Jayanthi, M. Sivaraju","doi":"10.31788/rjc.2023.1628362","DOIUrl":"https://doi.org/10.31788/rjc.2023.1628362","url":null,"abstract":"Corrosion is a significant issue with metallic materials, notably in steel due to its extensive use in a variety of industries. Benzoxazine polymers have been used to produce anti-corrosive compounds that have a remarkable ability to limit corrosion. In the same ink line, we have explored a new approach with a very hydrophobic benzoxazine monomer which is co-polymerized with urethane, and its characterization was studied with IR, UV, and NMR techniques. The corrosion resistance of the same is investigated using Tafel polarization and EIS experiment methodologies. The DFT and MEP studies explain the reactivity towards the anti-corrosive properties of the monomer.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1638352
K. Sangeetha, K. K. Aravindakshan
This article reports on the 3-formylchromone N(4)-substituted thiosemicarbazone’s coordination behavior towards transition metal ions. CHNS analysis, magnetic moment, thermal analysis, IR, UV, NMR, and EPR spectroscopy were used to characterize the compounds. Moreover, DFT, insilico ADME, and docking studies of the ligand were done. Based on the spectral results, copper, cobalt, and nickel complexes had square planar geometry. Conversely, the manganese complex has octahedral geometry. The Gaussian 09 program is utilized for DFT studies. The GLIDE program was used for docking calculations. As receptor molecules, histone deacetylase, ribonucleotide reductase, and DNA methyltransferase were chosen. The SwissADME tool was used to evaluate the pharmacokinetics of the ligand. Based on Lipinski's rules, the estimation of insilico ADMET discovered that ligands procure significant drug-likeness characteristics. Its ability to block histone deacetylase 8 (PDB ID 1T69) protein is shown by docking calculations, and its proper action can be further confirmed in wet lab tests.
本文报道了3-甲酰基色素N(4)-取代硫代氨基脲对过渡金属离子的配位行为。利用CHNS分析、磁矩分析、热分析、IR、UV、NMR和EPR光谱对化合物进行了表征。此外，还对该配体进行了DFT、硅基ADME和对接研究。根据光谱结果，铜、钴和镍配合物具有方形平面几何形状。相反，锰配合物具有八面体的几何形状。利用高斯09程序进行DFT研究。GLIDE程序用于对接计算。受体分子选择组蛋白去乙酰化酶、核糖核苷酸还原酶和DNA甲基转移酶。使用SwissADME工具评估配体的药代动力学。基于Lipinski的规则，对insilico ADMET的估计发现配体具有显著的药物相似性特征。对接计算显示其阻断组蛋白去乙酰化酶8 (PDB ID 1T69)蛋白的能力，其适当的作用可在湿实验室试验中进一步证实。
{"title":"COORDINATION BEHAVIOUR AND COMPUTATIONAL STUDIES OF 3-FORMYL CHROMONE N(4)-METHYL-N(4)- PHENYLTHIOSEMICARBAZONE AND ITS TRANSITION METAL COMPLEXES","authors":"K. Sangeetha, K. K. Aravindakshan","doi":"10.31788/rjc.2023.1638352","DOIUrl":"https://doi.org/10.31788/rjc.2023.1638352","url":null,"abstract":"This article reports on the 3-formylchromone N(4)-substituted thiosemicarbazone’s coordination behavior towards transition metal ions. CHNS analysis, magnetic moment, thermal analysis, IR, UV, NMR, and EPR spectroscopy were used to characterize the compounds. Moreover, DFT, insilico ADME, and docking studies of the ligand were done. Based on the spectral results, copper, cobalt, and nickel complexes had square planar geometry. Conversely, the manganese complex has octahedral geometry. The Gaussian 09 program is utilized for DFT studies. The GLIDE program was used for docking calculations. As receptor molecules, histone deacetylase, ribonucleotide reductase, and DNA methyltransferase were chosen. The SwissADME tool was used to evaluate the pharmacokinetics of the ligand. Based on Lipinski's rules, the estimation of insilico ADMET discovered that ligands procure significant drug-likeness characteristics. Its ability to block histone deacetylase 8 (PDB ID 1T69) protein is shown by docking calculations, and its proper action can be further confirmed in wet lab tests.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69412575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1617061
H. Sutanto, I. Alkian, Ulfa Hasanah, E. Hidayanto, I. Marhaendrajaya, Priyono
Waste dyes are a major source of water pollution, which is a critical environmental issue. The purpose of this study is to synthesize double-layer ZnO: Fe 5-20% thin films and investigate the degradation of rhodamine B in these films. The creation of the ZnO phase with the wurtzite hexagonal structure may be seen in the thin film X-ray diffraction pattern. Only marginally lessened energy bandgap (3.11-3.09 eV), optical transmission spectra, and lattice strain was seen after Fe was added to ZnO thin films. With increasing Fe concentration, it was found that the hydrophilicity and photocatalytic characteristics of ZnO thin films considerably decreased, as shown by the contact angle going from 51.4 to 70.71 and the decomposition efficiency going from 61.46% to 50.35%. The double-layer ZnO layer's optical characteristics diminish as the Fe concentration rises.
{"title":"PHOTOCATALYTIC DEGRADATION OF RHODAMINE B UNDER UV USING DOUBLE-LAYER ZnO: Fe THIN FILM","authors":"H. Sutanto, I. Alkian, Ulfa Hasanah, E. Hidayanto, I. Marhaendrajaya, Priyono","doi":"10.31788/rjc.2023.1617061","DOIUrl":"https://doi.org/10.31788/rjc.2023.1617061","url":null,"abstract":"Waste dyes are a major source of water pollution, which is a critical environmental issue. The purpose of this study is to synthesize double-layer ZnO: Fe 5-20% thin films and investigate the degradation of rhodamine B in these films. The creation of the ZnO phase with the wurtzite hexagonal structure may be seen in the thin film X-ray diffraction pattern. Only marginally lessened energy bandgap (3.11-3.09 eV), optical transmission spectra, and lattice strain was seen after Fe was added to ZnO thin films. With increasing Fe concentration, it was found that the hydrophilicity and photocatalytic characteristics of ZnO thin films considerably decreased, as shown by the contact angle going from 51.4 to 70.71 and the decomposition efficiency going from 61.46% to 50.35%. The double-layer ZnO layer's optical characteristics diminish as the Fe concentration rises.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69409791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618113
Suharni P. Sinaga, R. Situmorang, N. Singarimbun, W. Lestari, K. Gurning
Nangka (Artocarpus heterophyllus Lam.) has various nutritional contents and abundant bioactive compounds. Potential bioactive compounds including phenolic and flavonoid categorized as antioxidants. This study aimed to determine the levels of phenolics and flavonoids and to test their potential activity as antioxidants from the ethanol extract of nangka leaves. The extraction process used ethanol by maceration method, colorimetric determination of phenolic, flavonoid, and tannins content, and determination of antioxidant activity by 2,2-dipicryl -1-hydrazil (DPPH) method using UV-Vis spectrophotometry. Determination of phenolic content was measured at a maximum wavelength of 765 nm with gallic acid as the standard, flavonoid content was measured at a maximum wavelength of 431 nm with quercetin as standard, tannins content was measured at a maximum wavelength of 745 nm with tannic acid as standard and the determination of antioxidant activity at a maximum wavelength of 517 nm with positive control of vitamin C. The results showed that the ethanolic extract of nangka leaves has phenolic content with a total phenolic content of 27.654±0.054 mg GAE/g d.w ethanolic, flavonoid content of 2.978 ±0.192 mg QE/g d.w ethanolic, tannins content 0.46 ± 0.017 mg TAE/g d.w ethanolic extract and antioxidant activity (IC50) 25.561±0.055 ppm which categorized as a very strong antioxidant
{"title":"DETERMINATION OF TOTAL PHYTOCHEMICAL COMPOUNDS FROM ETHANOL EXTRACT NANGKA (Artocarpus heterophyllus Lam.) LEAVES AND ANTIOXIDANT ACTIVITY FROM NORTH SUMATERA, INDONESIA","authors":"Suharni P. Sinaga, R. Situmorang, N. Singarimbun, W. Lestari, K. Gurning","doi":"10.31788/rjc.2023.1618113","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618113","url":null,"abstract":"Nangka (Artocarpus heterophyllus Lam.) has various nutritional contents and abundant bioactive compounds. Potential bioactive compounds including phenolic and flavonoid categorized as antioxidants. This study aimed to determine the levels of phenolics and flavonoids and to test their potential activity as antioxidants from the ethanol extract of nangka leaves. The extraction process used ethanol by maceration method, colorimetric determination of phenolic, flavonoid, and tannins content, and determination of antioxidant activity by 2,2-dipicryl -1-hydrazil (DPPH) method using UV-Vis spectrophotometry. Determination of phenolic content was measured at a maximum wavelength of 765 nm with gallic acid as the standard, flavonoid content was measured at a maximum wavelength of 431 nm with quercetin as standard, tannins content was measured at a maximum wavelength of 745 nm with tannic acid as standard and the determination of antioxidant activity at a maximum wavelength of 517 nm with positive control of vitamin C. The results showed that the ethanolic extract of nangka leaves has phenolic content with a total phenolic content of 27.654±0.054 mg GAE/g d.w ethanolic, flavonoid content of 2.978 ±0.192 mg QE/g d.w ethanolic, tannins content 0.46 ± 0.017 mg TAE/g d.w ethanolic extract and antioxidant activity (IC50) 25.561±0.055 ppm which categorized as a very strong antioxidant","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618078
J. Tarigan, D. Barus, G. Brahmana, D. A. Hulu, W.S. Sembiring, S. Perangin-angin, E. K. Sitepu
In the present research, a microwave-intensified esterification reaction of myristic acid and palmitic acid with isopropyl alcohol (IPA) to produce an emollient ester using Amberlyst46 as a catalyst was studied. The effect of the ratio of molar fatty acid to alcohol, catalyst weight, reaction time, and microwave power on isopropyl myristate (IPM) and isopropyl palmitate (IPP) conversion and yield were investigated systematically. The results showed that catalyst weight and microwave power significantly affect the conversion and yield of IPM and IPP, respectively. The maximum conversion and yield of IPM were achieved under microwave irradiation power of 100% and catalyst weight of 15 wt.% while only 50% microwave power was required to achieve maximum conversion and yield of IPP using 18 wt.% of catalyst weight. These findings show that microwave-facilitated esterification reaction is a promising alternative method to produce emollient ester as the maximum conversion could achieve in a short reaction time.
{"title":"MICROWAVE FACILITATED THE SYNTHESIS OF ISOPROPYL MYRISTATE AND PALMITATE USING HETEROGENEOUS CATALYST","authors":"J. Tarigan, D. Barus, G. Brahmana, D. A. Hulu, W.S. Sembiring, S. Perangin-angin, E. K. Sitepu","doi":"10.31788/rjc.2023.1618078","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618078","url":null,"abstract":"In the present research, a microwave-intensified esterification reaction of myristic acid and palmitic acid with isopropyl alcohol (IPA) to produce an emollient ester using Amberlyst46 as a catalyst was studied. The effect of the ratio of molar fatty acid to alcohol, catalyst weight, reaction time, and microwave power on isopropyl myristate (IPM) and isopropyl palmitate (IPP) conversion and yield were investigated systematically. The results showed that catalyst weight and microwave power significantly affect the conversion and yield of IPM and IPP, respectively. The maximum conversion and yield of IPM were achieved under microwave irradiation power of 100% and catalyst weight of 15 wt.% while only 50% microwave power was required to achieve maximum conversion and yield of IPP using 18 wt.% of catalyst weight. These findings show that microwave-facilitated esterification reaction is a promising alternative method to produce emollient ester as the maximum conversion could achieve in a short reaction time.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618170
Pandurang Choudhari, P. V. Raut
At 32°C, the apparent molal volume (v), apparent molal compressibility (k), relative association (RA), and solvation number (Sn) of substituted 2-oxo-2-H-chromene-3-carbohydrazide derivatives in 60% DMF-water were measured. The data is used to determine the interaction that is taking place in the solution. The ultrasonic technique is used to determine the interaction of a solute and a solvent. The variation of factors in binary mixtures with different concentrations indicates a significant interaction between solute and solvent molecules, associative molecular interaction, and ion-solvent interaction.
在32℃下，测定了取代的2-氧-2- h -铬-3-碳腙衍生物在60% dmf水中的表观摩尔体积(v)、表观摩尔压缩性(k)、相对结合度(RA)和溶剂化数(Sn)。数据用于确定解决方案中发生的交互。超声波技术用于测定溶质和溶剂的相互作用。不同浓度二元混合物中各因子的变化表明溶质分子与溶剂分子之间存在显著的相互作用、缔合分子相互作用和离子-溶剂相互作用。
{"title":"STUDY OF MOLECULAR INTERACTIONS OF SUBSTITUTED 2-OXO-2-H-CHROMENE-3-CARBOHYDRAZIDE DERIVATIVES IN BINARY SOLVENTS USING ULTRASONIC INTERFEROMETER","authors":"Pandurang Choudhari, P. V. Raut","doi":"10.31788/rjc.2023.1618170","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618170","url":null,"abstract":"At 32°C, the apparent molal volume (v), apparent molal compressibility (k), relative association (RA), and solvation number (Sn) of substituted 2-oxo-2-H-chromene-3-carbohydrazide derivatives in 60% DMF-water were measured. The data is used to determine the interaction that is taking place in the solution. The ultrasonic technique is used to determine the interaction of a solute and a solvent. The variation of factors in binary mixtures with different concentrations indicates a significant interaction between solute and solvent molecules, associative molecular interaction, and ion-solvent interaction.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1628154
Palla Sai Lakshmi, P. Shankaraiah
A novel analog of substituted-(E)-2-benzylidene-N-(3-(3-oxo-2,3-dihydro-4H-benzo[b] [1,4] oxazin-4-yl)propyl) hydrazine-1-carbothioamides (9a-j) appeared to be assess being anti-proliferative activity in vitro environment some of the newly derived derivatives have shown sufficiently great to modest suppression in the number of cells in cancer among GrowthInhibition50 was (0.180-4.20 µM). Compounds 9a, 9b, 9d, 9g, 9i, and 9j showed promising acts contrarily 4 human being tumor cell lines. Out of 9a and 9g displayed heartening cancer act in opposition to IMR-32 (Human being neuroblastoma cells) at 0.23 M and MIAPACA(human pancreatic carcinoma cells) at 0.18 M respectively. Notably, compound 9g showed significant activity at 0.18 M against the MIAPACA cell line respectively.
{"title":"IN VITRO ANTI-PROLIFERATIVE ACTIVITY OF NOVEL ANALOGUES OF(E)-2-BENZYLIDENE-N-(3-(3-OXO-2,3- DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)PROPYL) HYDRAZINE-1-CARBOTHIOAMIDE","authors":"Palla Sai Lakshmi, P. Shankaraiah","doi":"10.31788/rjc.2023.1628154","DOIUrl":"https://doi.org/10.31788/rjc.2023.1628154","url":null,"abstract":"A novel analog of substituted-(E)-2-benzylidene-N-(3-(3-oxo-2,3-dihydro-4H-benzo[b] [1,4] oxazin-4-yl)propyl) hydrazine-1-carbothioamides (9a-j) appeared to be assess being anti-proliferative activity in vitro environment some of the newly derived derivatives have shown sufficiently great to modest suppression in the number of cells in cancer among GrowthInhibition50 was (0.180-4.20 µM). Compounds 9a, 9b, 9d, 9g, 9i, and 9j showed promising acts contrarily 4 human being tumor cell lines. Out of 9a and 9g displayed heartening cancer act in opposition to IMR-32 (Human being neuroblastoma cells) at 0.23 M and MIAPACA(human pancreatic carcinoma cells) at 0.18 M respectively. Notably, compound 9g showed significant activity at 0.18 M against the MIAPACA cell line respectively.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1628212
J. Panchal, B. Dhaduk, J. Dhalani
Remogliflozin and Vildagliptin are the latest drug combination in order to treat type 2 diabetes. The present work describes a comparative study of 2nd-ordered derivative UV and isocratic stability indicating RP-HPLC methods for simultaneous determination of Remogliflozin and Vildagliptin in the drug and its formulation. The HPLC method was established with a C18 column and the mobile phase with Buffer (pH-6.50): Acetonitrile: Methanol ratio of 55:44:1, at 1.2 ml/min flow and wavelength of 210 nm. The UV spectrophotometric method works on spectrophotometry with 2nd order derivative spectra(2D) using a zero-line cross method. The absorbance determination was performed at 246.0 nm for REM and at 219 .6 nm for VIL. The methods were validated for Linearity, Precision, Recovery, Robustness, and Forced degradation as per ICH-Q2(R1). The linear range was established in the range of 4-80 ppm for REM and 2-40 ppm for VIL for the UV method and 2-200 ppm for REM and 1-100 ppm for VIL for the HPLC method with regression coefficient ≥0.990. The accuracy was 99.37% & 99.62% for UV and 100.98 & 100.65 for the HPLC method for REM and VIL respectively. The proposed methods have been effectively used for the quantification of REM and VIL in API mixture and formulation dosage forms. Both methods are economical, fast, simple, and accurate which can be easily adopted for laboratory use.
{"title":"STABILITY INDICATING ISOCRATIC RP-HPLC AND SECOND DERIVATIVE UV SPECTROSCOPIC METHODS FOR SIMULTANEOUS DETERMINATION OF REMOGLIFLOZIN ETABONATE AND VILDAGLIPTIN HYDROCHLORIDE","authors":"J. Panchal, B. Dhaduk, J. Dhalani","doi":"10.31788/rjc.2023.1628212","DOIUrl":"https://doi.org/10.31788/rjc.2023.1628212","url":null,"abstract":"Remogliflozin and Vildagliptin are the latest drug combination in order to treat type 2 diabetes. The present work describes a comparative study of 2nd-ordered derivative UV and isocratic stability indicating RP-HPLC methods for simultaneous determination of Remogliflozin and Vildagliptin in the drug and its formulation. The HPLC method was established with a C18 column and the mobile phase with Buffer (pH-6.50): Acetonitrile: Methanol ratio of 55:44:1, at 1.2 ml/min flow and wavelength of 210 nm. The UV spectrophotometric method works on spectrophotometry with 2nd order derivative spectra(2D) using a zero-line cross method. The absorbance determination was performed at 246.0 nm for REM and at 219 .6 nm for VIL. The methods were validated for Linearity, Precision, Recovery, Robustness, and Forced degradation as per ICH-Q2(R1). The linear range was established in the range of 4-80 ppm for REM and 2-40 ppm for VIL for the UV method and 2-200 ppm for REM and 1-100 ppm for VIL for the HPLC method with regression coefficient ≥0.990. The accuracy was 99.37% & 99.62% for UV and 100.98 & 100.65 for the HPLC method for REM and VIL respectively. The proposed methods have been effectively used for the quantification of REM and VIL in API mixture and formulation dosage forms. Both methods are economical, fast, simple, and accurate which can be easily adopted for laboratory use.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1638301
S. Wulandari, U. Alizar, U.K. Nizar, I. M. Isa, A.B. Norlaili, Yulkifli, Ramli, L. Tan
The development of conductive polyaniline (PANI) membrane doped with copper(II) oxide (CuO) by means of the photopolymerization method has been successfully carried out. The photocurable PANI polymeric material was synthesized by mixing 0.011 g of aniline monomer with 0.016 g of ethylene glycol dimethacrylate (EGDMA) crosslinker, 0.021 g of dimethoxy phenylacetophenone (DMPP) photoinitiator and 0.026 g of CuO dopant. The electrical conductivity analysis showed that the as-synthesized CuO-doped PANI (PANI/CuO) film possessed an optimum electrical conductivity value of 39.81×10 -3 S cm -1 at the dopant loading of 0.011 g CuO. Chemical elucidation by using Fourier-transform infrared spectroscopy (FTIR) revealed that the PANI/CuO conducting material with several main functional groups e.g., N-H, C-H, C-N, C=C, C=N, C-O and C=O chemical bonds were identified. Meanwhile, optical characterization of the resulting PANI/CuO membrane by using UV–vis diffuse reflectance spectrophotometer (DR/UV-vis) showed that PANI underwent electron transition π-π* (C=C) at a wavelength of 324 nm, and band gap values of 2.35 eV, 1.33 eV, 1.39 eV, 1.42 eV, 1.42 eV, and 1.50 eV for PANI, PANI/CuO 0.011 g, PANI/CuO 0.016 g, PANI/CuO 0.021 g, PANI/CuO 0.026 g, and CuO, respectively.
采用光聚合法制备了掺杂氧化铜的导电聚苯胺(PANI)膜。以0.011 g苯胺单体、0.016 g乙二醇二甲基丙烯酸酯(EGDMA)交联剂、0.021 g二甲氧基苯乙酮(DMPP)光引发剂和0.026 g氧化铜掺杂剂为原料，合成了可光固化的聚苯胺聚合物材料。电导率分析表明，当掺杂量为0.011 g CuO时，合成的掺CuO聚苯胺(PANI/CuO)薄膜的电导率最佳值为39.81×10 -3 S cm -1。利用傅里叶红外光谱(FTIR)对其进行化学解析，鉴定出具有N- h、C- h、C-N、C=C、C=N、C-O和C=O等主要官能团的PANI/CuO导电材料。同时，利用UV-vis漫反射分光光度计(DR/UV-vis)对制备的PANI/CuO薄膜进行了光学表征，结果表明PANI在324 nm波长处发生了π-π* (C=C)跃迁，PANI、PANI/CuO 0.011 g、PANI/CuO 0.016 g、PANI/CuO 0.021 g、PANI/CuO 0.026 g和CuO的能带值分别为2.35 eV、1.33 eV、1.39 eV、1.42 eV、1.42 eV和1.50 eV。
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