Prostaglandins & other lipid mediators最新文献_第2页

Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-28 DOI: 10.1016/j.prostaglandins.2024.106936

R Sundaram , K Muthu

Hyperlipidemia is a well-known risk factor for atherosclerosis and subsequent atherosclerotic cardiovascular diseases that are associated with high morbidity and mortality in obese and diabetic patients worldwide. The current study looked on rosmarinic acid's cadioprotective effects in rats fed a high-fat diet as there was no study on this aspect. The rats were given a high-fat diet comprising of 84.3 % conventional laboratory rat chow, 5 % lard, 10 % egg yolk powder, 0.2 % cholesterol, and 0.5 % bile salt to produce hypercholesterolemia. Over a span of eight weeks. The plasma lipid profile, cardiac marker enzymes, membrane bound ATPases, lysosomal enzymes, CRP, fibrinogen, proinflammatory cytokines (IL-1β, IL-6,TNF-α, NF-κB),anti-inflammatory cytokine(IL-10) lipid peroxidation markers, enzymatic and non-enzymatic antioxidant enzymes activity were examined. The thoracic aorta's histopathology was also analyzed. It was discovered that the rats fed a high-fat diet had hypercholesterolemia and showed aberrant values in the aforementioned parameters. However, rats given rosmarinic acid (100 mg/kg b.w.) had these anomalies reversed to near-normal levels. The biochemical investigation was corroborated by enhanced histological examination of the thoracic aorta in rats suffering from hypercholestolemia. The effects of rosmarinic acid on a number of measures were similar to those of the prescription medication simvastatin. These findings revealed that rosmarinic acid is an important component in the cardiovascular system's defence against a high-fat diet induced hypercholesterolemia

{"title":"Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats","authors":"R Sundaram , K Muthu","doi":"10.1016/j.prostaglandins.2024.106936","DOIUrl":"10.1016/j.prostaglandins.2024.106936","url":null,"abstract":"<div><div>Hyperlipidemia is a well-known risk factor for atherosclerosis and subsequent atherosclerotic cardiovascular diseases that are associated with high morbidity and mortality in obese and diabetic patients worldwide. The current study looked on rosmarinic acid's cadioprotective effects in rats fed a high-fat diet as there was no study on this aspect. The rats were given a high-fat diet comprising of 84.3 % conventional laboratory rat chow, 5 % lard, 10 % egg yolk powder, 0.2 % cholesterol, and 0.5 % bile salt to produce hypercholesterolemia. Over a span of eight weeks. The plasma lipid profile, cardiac marker enzymes, membrane bound ATPases, lysosomal enzymes, CRP, fibrinogen, proinflammatory cytokines (IL-1β, IL-6,TNF-α, NF-κB),anti-inflammatory cytokine(IL-10) lipid peroxidation markers, enzymatic and non-enzymatic antioxidant enzymes activity were examined. The thoracic aorta's histopathology was also analyzed. It was discovered that the rats fed a high-fat diet had hypercholesterolemia and showed aberrant values in the aforementioned parameters. However, rats given rosmarinic acid (100 mg/kg b.w.) had these anomalies reversed to near-normal levels. The biochemical investigation was corroborated by enhanced histological examination of the thoracic aorta in rats suffering from hypercholestolemia. The effects of rosmarinic acid on a number of measures were similar to those of the prescription medication simvastatin. These findings revealed that rosmarinic acid is an important component in the cardiovascular system's defence against a high-fat diet induced hypercholesterolemia</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106936"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cigarette smoke-induced attenuation of the prostaglandin transporter SLCO2A1 expression through aryl hydrocarbon receptor.

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-26 DOI: 10.1016/j.prostaglandins.2024.106935

Melody N Shumba, Yoshinobu Nakamura, Takeo Nakanishi

SLCO2A1 is a prostaglandin transporter and contributes to regulating local concentration of an inflammatory mediator, PGE₂. Since we previously found that cigarette smoke extracts (CSE) reduced Slco2a1 mRNA expression in rat alveolar epithelial cells, the current study aimed to investigate the effect of CSE on human SLCO2A1 mRNA expression across cell lines from organs that are susceptible to tobacco smoking-induced inflammation. 5'-Flanking regions of SLCO2A1 up to 3673 bp upstream of the transcription start site (+1) was sub-cloned into a luciferase (LUC) expression vector, and promoter activity was evaluated by a reporter assay. CSE significantly reduced SLCO2A1 mRNA expression and LUC activity driven by the construct of -3673/+4 in colon epithelial LoVo and Caco-2 and lung mucoepidermoid NCI-H292 cells, but not in liver epithelial-like HepG2 cells. Long-term exposure of LoVo cells to CSE completely suppressed SLCO2A1 protein expression. The CSE-mediated effect on LUC activity was restored by an AHR antagonist PD98059 and a known AHR ligand β-naphthoflavone significantly reduced SLCO2A1 mRNA expression in cells. Concomitantly, the CSE-mediated negative regulation of SLCO2A1 was abolished in cells transfected with the construct of -3673/+4 with mutated xenobiotic response element. Furthermore, PD98059 and an AHR inhibitor perillaldehyde diminished the negative effect of CSE on SLCO2A1 mRNA expression in Lovo, NCI-H292 and Caco-2 cells. These results demonstrate that CSE negatively modulates SLCO2A1 transcription through AHR activation, providing a toxicological implication of tobacco smoke-induced inflammation.

{"title":"Cigarette smoke-induced attenuation of the prostaglandin transporter SLCO2A1 expression through aryl hydrocarbon receptor.","authors":"Melody N Shumba, Yoshinobu Nakamura, Takeo Nakanishi","doi":"10.1016/j.prostaglandins.2024.106935","DOIUrl":"10.1016/j.prostaglandins.2024.106935","url":null,"abstract":"<p><p>SLCO2A1 is a prostaglandin transporter and contributes to regulating local concentration of an inflammatory mediator, PGE<sub>2</sub>. Since we previously found that cigarette smoke extracts (CSE) reduced Slco2a1 mRNA expression in rat alveolar epithelial cells, the current study aimed to investigate the effect of CSE on human SLCO2A1 mRNA expression across cell lines from organs that are susceptible to tobacco smoking-induced inflammation. 5'-Flanking regions of SLCO2A1 up to 3673 bp upstream of the transcription start site (+1) was sub-cloned into a luciferase (LUC) expression vector, and promoter activity was evaluated by a reporter assay. CSE significantly reduced SLCO2A1 mRNA expression and LUC activity driven by the construct of -3673/+4 in colon epithelial LoVo and Caco-2 and lung mucoepidermoid NCI-H292 cells, but not in liver epithelial-like HepG2 cells. Long-term exposure of LoVo cells to CSE completely suppressed SLCO2A1 protein expression. The CSE-mediated effect on LUC activity was restored by an AHR antagonist PD98059 and a known AHR ligand β-naphthoflavone significantly reduced SLCO2A1 mRNA expression in cells. Concomitantly, the CSE-mediated negative regulation of SLCO2A1 was abolished in cells transfected with the construct of -3673/+4 with mutated xenobiotic response element. Furthermore, PD98059 and an AHR inhibitor perillaldehyde diminished the negative effect of CSE on SLCO2A1 mRNA expression in Lovo, NCI-H292 and Caco-2 cells. These results demonstrate that CSE negatively modulates SLCO2A1 transcription through AHR activation, providing a toxicological implication of tobacco smoke-induced inflammation.</p>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":" ","pages":"106935"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials. 醋酸甲羟孕酮对绝经后妇女脂蛋白和脂蛋白（a）浓度的影响：随机对照试验的荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-13 DOI: 10.1016/j.prostaglandins.2024.106919

Qiujin Cheng, Xiao Yan, Kousalya Prabahar, Zhu Ye

Background and aim: In view of the favorable effect of hormone replacement therapy (HRT) on the lipid profile in postmenopausal women, and the discrepancies that exist on the effect of medroxyprogesterone acetate (MPA) on lipoprotein concentrations and cardiovascular disease (CVD) risk, we conducted this meta-analysis of randomized controlled trials (RCT) to assess the efficacy of MPA on apolipoprotein and lipoprotein(a) concentrations in healthy postmenopausal women.

Methods: A systematic search was conducted across multiple databases, including for English-language papers published up to September 2023 comparing the effect of MPA on ApoA-I, Apo-AII, and Lp(a) levels with those of a control group. A meta-analysis was conducted using a random-effects model, reporting the results as the weighted mean difference (WMD) with a 95 % confidence interval (CI).

Results: The current meta-analysis included 11 publications. the comprehensive findings indicated a noteworthy reduction in ApoA-I (WMD:-8.70 mg/dL,95 %CI: -12.80, -4.59,P<0.001), a significant increase in Lp(a) concentrations (WMD: 1.36 mg/dL, 95 % CI: 0.10, 2.63, P=0.033), and a non-significant increase in ApoB concentrations (WMD: 0.57 mg/dL, 95 %CI: -1.25, 2.40, P=0.539) after the administration of MPA in postmenopausal women. In addition, a significant reduction in ApoB levels was identified in studies with a mean participant BMI ≥25 kg/m2 (WMD: -4.94 mg/dL, 95 %CI: -5.71 to -4.18,P< 0.001) and a greater impact on ApoA-1 and Lp(a) levels was observed in trials with doses of 5 mg/day compared with 2.5 mg/day.

Conclusion: MPA administration resulted in a significant increase in Lp(a) and decrease in ApoA-I levels and a non-significant increase in ApoB levels in healthy postmenopausal women.

背景和目的：鉴于激素替代疗法（HRT）对绝经后妇女血脂状况的有利影响，以及醋酸甲羟孕酮（MPA）对脂蛋白浓度和心血管疾病（CVD）风险影响的差异，我们对随机对照试验（RCT）进行了荟萃分析，以评估MPA对健康绝经后妇女载脂蛋白和脂蛋白（a）浓度的疗效：在多个数据库中进行了系统检索，包括检索截至2023年9月发表的、比较MPA对载脂蛋白A-I、载脂蛋白A-II和脂蛋白（a）水平的影响与对照组的影响的英文论文。采用随机效应模型进行荟萃分析，以加权平均差（WMD）和95%置信区间（CI）的形式报告结果：综合研究结果表明载脂蛋白 A-I 显著下降（WMD：-8.70 毫克/分升，95%CI：-12.80，-4.59）：服用 MPA 会导致健康绝经后妇女的脂蛋白（a）显著增加，载脂蛋白 A-I 水平下降，载脂蛋白 B 水平增加不明显。

{"title":"The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials.","authors":"Qiujin Cheng, Xiao Yan, Kousalya Prabahar, Zhu Ye","doi":"10.1016/j.prostaglandins.2024.106919","DOIUrl":"10.1016/j.prostaglandins.2024.106919","url":null,"abstract":"<p><strong>Background and aim: </strong>In view of the favorable effect of hormone replacement therapy (HRT) on the lipid profile in postmenopausal women, and the discrepancies that exist on the effect of medroxyprogesterone acetate (MPA) on lipoprotein concentrations and cardiovascular disease (CVD) risk, we conducted this meta-analysis of randomized controlled trials (RCT) to assess the efficacy of MPA on apolipoprotein and lipoprotein(a) concentrations in healthy postmenopausal women.</p><p><strong>Methods: </strong>A systematic search was conducted across multiple databases, including for English-language papers published up to September 2023 comparing the effect of MPA on ApoA-I, Apo-AII, and Lp(a) levels with those of a control group. A meta-analysis was conducted using a random-effects model, reporting the results as the weighted mean difference (WMD) with a 95 % confidence interval (CI).</p><p><strong>Results: </strong>The current meta-analysis included 11 publications. the comprehensive findings indicated a noteworthy reduction in ApoA-I (WMD:-8.70 mg/dL,95 %CI: -12.80, -4.59,P<0.001), a significant increase in Lp(a) concentrations (WMD: 1.36 mg/dL, 95 % CI: 0.10, 2.63, P=0.033), and a non-significant increase in ApoB concentrations (WMD: 0.57 mg/dL, 95 %CI: -1.25, 2.40, P=0.539) after the administration of MPA in postmenopausal women. In addition, a significant reduction in ApoB levels was identified in studies with a mean participant BMI ≥25 kg/m2 (WMD: -4.94 mg/dL, 95 %CI: -5.71 to -4.18,P< 0.001) and a greater impact on ApoA-1 and Lp(a) levels was observed in trials with doses of 5 mg/day compared with 2.5 mg/day.</p><p><strong>Conclusion: </strong>MPA administration resulted in a significant increase in Lp(a) and decrease in ApoA-I levels and a non-significant increase in ApoB levels in healthy postmenopausal women.</p>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":" ","pages":"106919"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis 补充葡萄糖甘露聚糖是否会对成人血清脂质状况产生有利影响？系统回顾和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-09 DOI: 10.1016/j.prostaglandins.2024.106934

Zhu Haijun , Zhang Ke , Zhang Dawei , Amir Reza Haedi , Elika Poorasadollah , Cheng Cheng

Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: −2.26; 95 % CI: −2.98, −1.55, p <0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: −2.57; 95 % CI: −3.41, −1.74; p<0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: −0.33; 95 % CI: −0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: −0.16; 95 % CI: −0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.

考虑到血脂异常对心血管疾病甚至慢性疾病的影响，以及葡甘聚糖对血脂异常的有益作用，本研究旨在深入研究葡甘聚糖如何影响血脂谱参数。本研究使用标准关键词，在 Scopus、PubMed、Embase、Web of Science 数据库和 Google Scholar 等数据库中检索了从开始到 2024 年 12 月的所有研究。研究发现，葡甘聚糖能显著降低总胆固醇（TC）（SMD：-2.26；95% CI：-2.98，-1.55，p

{"title":"Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis","authors":"Zhu Haijun , Zhang Ke , Zhang Dawei , Amir Reza Haedi , Elika Poorasadollah , Cheng Cheng","doi":"10.1016/j.prostaglandins.2024.106934","DOIUrl":"10.1016/j.prostaglandins.2024.106934","url":null,"abstract":"<div><div>Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: −2.26; 95 % CI: −2.98, −1.55, p <0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: −2.57; 95 % CI: −3.41, −1.74; p<0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: −0.33; 95 % CI: −0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: −0.16; 95 % CI: −0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106934"},"PeriodicalIF":2.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age "维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响"。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-08 DOI: 10.1016/j.prostaglandins.2024.106920

Juanjuan Zhu , Bingbing Wang , Sanaz Asemani , Shiwei Bao , Niannian Tian

Objective

The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children’s serum calcium, alkaline Phosphatase, and bone Age.

Methods

The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.

Results

Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P<0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.

Conclusion

The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.

研究目的研究旨在探讨维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响方法：研究分析了 159 名接受体检的学龄儿童的临床数据。根据儿童血清中 25- 羟基维生素 D3 的水平，将其分为 25-(OH)D3 缺乏组和非 25-(OH)D3 缺乏组。两组儿童的体重指数（BMI）、总胆固醇（TC）、总胆固醇（TG）、血糖（FBG）、糖化血红蛋白（HbA1c）、钙（Ca）、谷丙转氨酶（ALP）和骨龄差异进行了比较：结果：与缺乏 25-(OH)D3 的人相比，缺乏 25-(OH)D3 的人的 BMI、TC、TG 和 ALP 水平较高，而 Ca 和骨龄水平较低。这些差异具有统计学意义（PC结论：学龄儿童缺乏 25-(OH)D3 与肥胖有关，并影响骨骼生长。监测维生素 D 水平对临床医师至关重要。

{"title":"The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age","authors":"Juanjuan Zhu , Bingbing Wang , Sanaz Asemani , Shiwei Bao , Niannian Tian","doi":"10.1016/j.prostaglandins.2024.106920","DOIUrl":"10.1016/j.prostaglandins.2024.106920","url":null,"abstract":"<div><h3>Objective</h3><div>The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children’s serum calcium, alkaline Phosphatase, and bone Age.</div></div><div><h3>Methods</h3><div>The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.</div></div><div><h3>Results</h3><div>Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P<0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.</div></div><div><h3>Conclusion</h3><div>The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106920"},"PeriodicalIF":2.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of meal replacements formula on lipid profiles: A systematic review and meta-analysis of randomized controlled trials. 代餐配方对血脂曲线的影响：随机对照试验的系统回顾和元分析》。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-04 DOI: 10.1016/j.prostaglandins.2024.106921

Yu Qiao, Xue Xiao, Huijie Yu, Junying Zhang, Mohammad Hassan Sohouli, Somaye Fatahi, Nathalia Sernizon Guimarães

Background: Although some evidence shows the beneficial effects of meal replacements (MRs) on dyslipidaemias, it is not completely clear. Therefore, we investigate the possible effects of total and partial MRs on lipid profiles.

Methods: For this systematic review and meta-analysis, we searched MEDLINE, Web of Science, SCOPUS, and Embase. We included randomized controlled trials (RCTs) that evaluated the effect of MRs on lipid profiles. A random-effects meta-analysis model was used to combine studies and calculate weighted mean difference and 95 % confidence intervals (95 % CI). Subgroup analysis was realized using intervention type, duration and average participant age.

Results: Fifty-one studies were included. The pooled findings showed that total and partial MRs significantly reduced triglycerides (TG) (WMD: -12.20 mg/dl, 95 % CI -17.46 to -6.93) and increased high-density lipoprotein (HDL) (WMD: 1.06 mg/dl, 95 % CI 0.35-1.77) compared to controls. However, total cholesterol (TC) (WMD: -1.40 mg/dl, 95 % CI: -3.90-1.10) and low-density lipoprotein (LDL) (WMD: -0.85 mg/dl, 95 % CI: -3.05-1.35) were not significant. In addition, the subgroup analysis shows a greater effect on TG reduction and HDL increase in the type of intervention with total MRs compared to partial MRs and during the intervention >24 weeks compared to ≤24 weeks.

Conclusions: MRs lead to significant improvements in TG and HDL levels. These results may help strengthen programs for dyslipidaemias prevention/management.

背景：尽管有证据表明代餐（MR）对血脂异常有好处，但并不完全清楚。因此，我们研究了全部代餐和部分代餐对血脂状况可能产生的影响：为了进行系统回顾和荟萃分析，我们检索了 MEDLINE、Web of Science、SCOPUS 和 Embase。我们纳入了评估 MR 对血脂状况影响的随机对照试验 (RCT)。我们采用随机效应荟萃分析模型来合并研究，并计算加权平均差和 95% 置信区间 (95%CI)。利用干预类型、持续时间和参与者平均年龄进行了分组分析：结果：共纳入 51 项研究。汇总结果显示，与对照组相比，总胆固醇和部分胆固醇干预能显著降低甘油三酯（TG）（WMD：-12.20mg/dl，95% CI -17.46至-6.93），增加高密度脂蛋白（HDL）（WMD：1.06mg/dl，95% CI 0.35至1.77）。然而，总胆固醇（TC）（WMD：-1.40 毫克/分升，95% CI：-3.90 至 1.10）和低密度脂蛋白（LDL）（WMD：-0.85 毫克/分升，95% CI：-3.05 至 1.35）的增加并不显著。此外，亚组分析显示，与部分MRs相比，全部MRs干预类型对降低总胆固醇和增加高密度脂蛋白的效果更大；与≤24周的干预相比，>24周的干预对降低总胆固醇和增加高密度脂蛋白的效果更大：结论：MRs 可显著改善总胆固醇和高密度脂蛋白水平。这些结果可能有助于加强血脂异常预防/管理计划。

{"title":"Effect of meal replacements formula on lipid profiles: A systematic review and meta-analysis of randomized controlled trials.","authors":"Yu Qiao, Xue Xiao, Huijie Yu, Junying Zhang, Mohammad Hassan Sohouli, Somaye Fatahi, Nathalia Sernizon Guimarães","doi":"10.1016/j.prostaglandins.2024.106921","DOIUrl":"10.1016/j.prostaglandins.2024.106921","url":null,"abstract":"<p><strong>Background: </strong>Although some evidence shows the beneficial effects of meal replacements (MRs) on dyslipidaemias, it is not completely clear. Therefore, we investigate the possible effects of total and partial MRs on lipid profiles.</p><p><strong>Methods: </strong>For this systematic review and meta-analysis, we searched MEDLINE, Web of Science, SCOPUS, and Embase. We included randomized controlled trials (RCTs) that evaluated the effect of MRs on lipid profiles. A random-effects meta-analysis model was used to combine studies and calculate weighted mean difference and 95 % confidence intervals (95 % CI). Subgroup analysis was realized using intervention type, duration and average participant age.</p><p><strong>Results: </strong>Fifty-one studies were included. The pooled findings showed that total and partial MRs significantly reduced triglycerides (TG) (WMD: -12.20 mg/dl, 95 % CI -17.46 to -6.93) and increased high-density lipoprotein (HDL) (WMD: 1.06 mg/dl, 95 % CI 0.35-1.77) compared to controls. However, total cholesterol (TC) (WMD: -1.40 mg/dl, 95 % CI: -3.90-1.10) and low-density lipoprotein (LDL) (WMD: -0.85 mg/dl, 95 % CI: -3.05-1.35) were not significant. In addition, the subgroup analysis shows a greater effect on TG reduction and HDL increase in the type of intervention with total MRs compared to partial MRs and during the intervention >24 weeks compared to ≤24 weeks.</p><p><strong>Conclusions: </strong>MRs lead to significant improvements in TG and HDL levels. These results may help strengthen programs for dyslipidaemias prevention/management.</p>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":" ","pages":"106921"},"PeriodicalIF":2.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials 补充蜂胶对炎症生物标志物的影响：随机对照临床试验的荟萃分析和系统回顾

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-28 DOI: 10.1016/j.prostaglandins.2024.106915

LUO Zhong-yong , Deng ZHi-qing , Xia Li-qiong , Elika Poorasadollah , Shabnam Shirvani

Recent interventional investigations suggest the beneficial impact of propolis supplementation on inflammatory biomarkers; however, the results have not been summarized in a comprehensive meta-analysis. We conducted this meta-analysis to summarize all available data and provide clear evidence for whether propolis supplementation affects inflammatory biomarkers. This systematic review with meta-analysis was performed by searching databases (PubMed/Medline, Web of Science, Scopus, and Embase) until February 2024. It included randomized clinical trials (RCTs) assessing the effects of propolis supplementation on inflammatory biomarkers in adults. This review included 20 RCTs with a total of 1139 participants. The propolis supplementation significantly reduced IL-6 (WMD = −2.48; 95 % CI: −4.62, −0.34; P = 0.023) and TNF-α (WMD = −0.86; 95 % CI: −1.45, −0.26; P = 0.005) compared with control groups. Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: −0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks. These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology. Due to the limited number of studies, clinical diversity, and other limitations, it is necessary to conduct more high-quality studies to provide more precise and comprehensive recommendations.

最近的干预性研究表明，补充蜂胶对炎症生物标志物有有益影响；然而，这些结果尚未在一项全面的荟萃分析中得到总结。我们进行了这项荟萃分析，以总结所有可用数据，为蜂胶补充剂是否影响炎症生物标志物提供明确证据。本系统综述和荟萃分析是通过检索数据库（PubMed/Medline、Web of Science、Scopus 和 Embase）进行的，检索期截至 2024 年 2 月。研究纳入了评估蜂胶补充剂对成人炎症生物标志物影响的随机临床试验（RCT）。该综述包括20项随机临床试验，共有1139人参与。与对照组相比，补充蜂胶可明显降低IL-6（WMD = -2.48；95 % CI：-4.62，-0.34；P = 0.023）和TNF-α（WMD = -0.86；95 % CI：-1.45，-0.26；P = 0.005）。虽然 CRP 浓度没有降低（WMD = 0.01；95 % CI：-0.03，0.05；P = 0.646），但补充时间≥ 10 周的 CRP 水平显著降低。这些结果表明，蜂胶对TNF-α和IL-6水平具有有益的影响，可作为一种有效的辅助疗法，用于治疗炎症是病因中关键因素的疾病。由于研究数量有限、临床多样性和其他局限性，有必要开展更多高质量的研究，以提供更准确、更全面的建议。

{"title":"The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials","authors":"LUO Zhong-yong , Deng ZHi-qing , Xia Li-qiong , Elika Poorasadollah , Shabnam Shirvani","doi":"10.1016/j.prostaglandins.2024.106915","DOIUrl":"10.1016/j.prostaglandins.2024.106915","url":null,"abstract":"<div><div>Recent interventional investigations suggest the beneficial impact of propolis supplementation on inflammatory biomarkers; however, the results have not been summarized in a comprehensive meta-analysis. We conducted this meta-analysis to summarize all available data and provide clear evidence for whether propolis supplementation affects inflammatory biomarkers. This systematic review with meta-analysis was performed by searching databases (PubMed/Medline, Web of Science, Scopus, and Embase) until February 2024. It included randomized clinical trials (RCTs) assessing the effects of propolis supplementation on inflammatory biomarkers in adults. This review included 20 RCTs with a total of 1139 participants. The propolis supplementation significantly reduced IL-6 (WMD = −2.48; 95 % CI: −4.62, −0.34; P = 0.023) and TNF-α (WMD = −0.86; 95 % CI: −1.45, −0.26; P = 0.005) compared with control groups. Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: −0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks. These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology. Due to the limited number of studies, clinical diversity, and other limitations, it is necessary to conduct more high-quality studies to provide more precise and comprehensive recommendations.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106915"},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between dietary inflammatory index with risk rheumatoid arthritis: A case-control study 膳食炎症指数与类风湿性关节炎之间的关系：一项病例对照研究。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106916

Zhejianyi Gao , Farhad Alishahi , Amirabbas Faridpour , Saeed Nezamoleslami , Shokufeh Nezamoleslami , Reza Ghiasvand , Ariyo Movahedi , Nitin Shivappa , James R. Hébert , Mahsa Jalalinejad , Asal Ataie-Jafari

Diet represents an important set of potential risk factors for rheumatoid arthritis (RA), a known inflammatory condition. This case-control study examined the association between the inflammatory potential of diet, as determined by the dietary inflammatory index (DII®), and RA risk in an Iranian population. The present Case–control study was conducted on 100 RA patients and 200 age- and sex-matched controls in Isfahan, Iran. The presence of RA was determined by expert Rheumatologist assessment based on the American College of Rheumatology definitions. A 168-item food frequency questionnaire was used to collect dietary intake from which DII scores were computed. Odds ratios (OR) and 95 % confidence intervals (CI) for the association between the DII, expressed in tertiles, and RA risk were estimated by two multivariable logistic regression models, one crude model and one in which we controlled for important potential confounders. In the crude model, individuals in the top DII tertile (most pro-inflammatory diet) had more than triple the risk of RA compared to those in the lowest tertile (OR_tertile3vs1= 3.57; 95 % CI, 1.95–6.53; p< 0.001). The association was essentially unchanged after controlling for potential confounders (OR _tertile3vs1 = 3.83; 95 % CI, 1.66–8.81; p<0.001). We found that a pro-inflammatory diet is associated with increased risk of RA. Higher volume studies are needed to confirm the results.

饮食是类风湿性关节炎（RA）的一组重要潜在风险因素，RA 是一种已知的炎症性疾病。这项病例对照研究考察了伊朗人群中饮食炎症指数（DII®）所确定的饮食炎症潜能与类风湿关节炎风险之间的关联。本病例对照研究的对象是伊朗伊斯法罕的 100 名 RA 患者和 200 名年龄和性别匹配的对照组。根据美国风湿病学会的定义，由风湿病专家进行评估，确定是否患有风湿性关节炎。研究人员使用了一份包含 168 个项目的食物频率问卷来收集饮食摄入量，并据此计算出 DII 分数。通过两个多变量逻辑回归模型（一个粗略模型和一个控制了重要潜在混杂因素的模型）估算了DII（以三等分表示）与RA风险之间的相关性的比率（OR）和95%置信区间（CI）。在粗略模型中，DII最高三分位数（最亲炎饮食）的人与最低三分位数的人相比，罹患RA的风险高出三倍多（ORtertile3vs1= 3.57；95% CI，1.95-6.53；p< 0.001）。在控制了潜在的混杂因素后，这种关联基本保持不变（OR tertile3vs1 = 3.83; 95% CI, 1.66-8.81; p

{"title":"The association between dietary inflammatory index with risk rheumatoid arthritis: A case-control study","authors":"Zhejianyi Gao , Farhad Alishahi , Amirabbas Faridpour , Saeed Nezamoleslami , Shokufeh Nezamoleslami , Reza Ghiasvand , Ariyo Movahedi , Nitin Shivappa , James R. Hébert , Mahsa Jalalinejad , Asal Ataie-Jafari","doi":"10.1016/j.prostaglandins.2024.106916","DOIUrl":"10.1016/j.prostaglandins.2024.106916","url":null,"abstract":"<div><div>Diet represents an important set of potential risk factors for rheumatoid arthritis (RA), a known inflammatory condition. This case-control study examined the association between the inflammatory potential of diet, as determined by the dietary inflammatory index (DII®), and RA risk in an Iranian population. The present Case–control study was conducted on 100 RA patients and 200 age- and sex-matched controls in Isfahan, Iran. The presence of RA was determined by expert Rheumatologist assessment based on the American College of Rheumatology definitions. A 168-item food frequency questionnaire was used to collect dietary intake from which DII scores were computed. Odds ratios (OR) and 95 % confidence intervals (CI) for the association between the DII, expressed in tertiles, and RA risk were estimated by two multivariable logistic regression models, one crude model and one in which we controlled for important potential confounders. In the crude model, individuals in the top DII tertile (most pro-inflammatory diet) had more than triple the risk of RA compared to those in the lowest tertile (OR<sub>tertile3vs1</sub>= 3.57; 95 % CI, 1.95–6.53; p<strong><</strong> 0.001<strong>)</strong>. The association was essentially unchanged after controlling for potential confounders (OR <sub>tertile3vs1</sub> = 3.83; 95 % CI, 1.66–8.81; p<strong><</strong>0.001<strong>)</strong>. We found that a pro<strong>-</strong>inflammatory diet is associated with increased risk of RA. Higher volume studies are needed to confirm the results.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106916"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation 选择性 mTORC2 抑制通过 IKKα/IκB-α/NF-κB 激活对 Zymosan 引起的低血压和全身炎症的保护作用。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106918

Zainab Sabrie , Meryem Temiz-Resitoglu , Taskin Kalkan , Banu Kilic , Bahar Tunctan , Kafait U. Malik , Seyhan Sahan-Firat

Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1) signaling pathway exerts potent anti-inflammatory activity, little is known about mTORC2’s contribution to non-septic shock. Thus, our research aims to investigate mTORC2's contribution and associated changes of IκB kinase (IKKα)/inhibitor κB (IκB-α)/nuclear factor-ĸB (NF-κB) pathway on Zymosan (ZYM)-induced non-septic rat model using the novel mTORC2 selective inhibitor JR-AB2–011. Rats were given saline (4 ml/kg), dimethylsulfoxide (DMSO) (4 ml/kg), ZYM (500 mg/kg), and (or) JR-AB2–011 (1 mg/kg). Mean arterial pressure (MAP) and heart rate (HR) of rats were recorded. JR-AB2–011 reversed both ZYM-induced reduction in MAP and increase in HR. Protein expression and/or phosphorylation of rictor, protein kinase B (Akt), IκB-α, IKKα, NF-κB p65, inducible nitric oxide synthase (iNOS), nitrotyrosine, cyclooxygenase 2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, besides prostaglandin (PG) E₂ levels were measured. The enhanced expression of the proteins mentioned above has been inhibited by JR-AB2–011. These data suggest mTORC2’s promising role in ZYM-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB pathway.

非败血症性休克是一种导致多器官功能障碍的严重疾病。尽管针对哺乳动物雷帕霉素靶标复合体 1（mTORC1）信号通路可发挥强效抗炎活性，但人们对 mTORC2 在非失血性休克中的作用知之甚少。因此，我们的研究旨在利用新型 mTORC2 选择性抑制剂 JR-AB2-011，研究 mTORC2 对齐莫散（ZYM）诱导的非败血症大鼠模型的贡献以及 IκB 激酶（IKKα）/抑制因子κB（IκB-α）/核因子ĸB（NF-κB）通路的相关变化。给大鼠注射生理盐水（4 毫升/千克）、二甲基亚砜（DMSO）（4 毫升/千克）、ZYM（500 毫克/千克）和（或）JR-AB2-011（1 毫克/千克）。记录大鼠的平均动脉压（MAP）和心率（HR）。JR-AB2-011 逆转了 ZYM 诱导的 MAP 降低和 HR 升高。对 rictor、蛋白激酶 B (Akt)、IκB-α、IKKα、NF-κB p65、诱导型一氧化氮合酶 (iNOS)、硝基酪氨酸、环氧化酶 2 (COX-2)、肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-1β 以及前列腺素 (PG) E2 水平的蛋白表达和/或磷酸化进行了测定。JR-AB2-011 可抑制上述蛋白的表达。这些数据表明，mTORC2 在通过 IKKα/IκB-α/NF-κB 通路介导的 ZYM 诱导的低血压和全身性炎症中发挥着重要作用。

{"title":"Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation","authors":"Zainab Sabrie , Meryem Temiz-Resitoglu , Taskin Kalkan , Banu Kilic , Bahar Tunctan , Kafait U. Malik , Seyhan Sahan-Firat","doi":"10.1016/j.prostaglandins.2024.106918","DOIUrl":"10.1016/j.prostaglandins.2024.106918","url":null,"abstract":"<div><div>Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1) signaling pathway exerts potent anti-inflammatory activity, little is known about mTORC2’s contribution to non-septic shock. Thus, our research aims to investigate mTORC2's contribution and associated changes of IκB kinase (IKKα)/inhibitor κB (IκB-α)/nuclear factor-ĸB (NF-κB) pathway on Zymosan (ZYM)-induced non-septic rat model using the novel mTORC2 selective inhibitor JR-AB2–011. Rats were given saline (4 ml/kg), dimethylsulfoxide (DMSO) (4 ml/kg), ZYM (500 mg/kg), and (or) JR-AB2–011 (1 mg/kg). Mean arterial pressure (MAP) and heart rate (HR) of rats were recorded. JR-AB2–011 reversed both ZYM-induced reduction in MAP and increase in HR. Protein expression and/or phosphorylation of rictor, protein kinase B (Akt), IκB-α, IKKα, NF-κB p65, inducible nitric oxide synthase (iNOS), nitrotyrosine, cyclooxygenase 2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, besides prostaglandin (PG) E<sub>2</sub> levels were measured. The enhanced expression of the proteins mentioned above has been inhibited by JR-AB2–011. These data suggest mTORC2’s promising role in ZYM-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB pathway.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106918"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials 马齿苋对 2 型糖尿病患者 C 反应蛋白、血脂状况和血糖控制的影响：对随机对照试验进行 GRADE 评估的系统综述和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-23 DOI: 10.1016/j.prostaglandins.2024.106917

Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang

Although numerous trials have demonstrated the benefits of purslane on patients with type 2 diabetes mellitus (T2DM), the results of some studies reject such effect. We elucidated the influence of purslane on c-reactive protein (CRP), lipid profile, and glycemic control in patients with T2DM. We conducted a systematic search on Web of Sciences, Scopus, the Cochrane Library, PubMed, and Embase, to identify studies published from their inception to February 10, 2024. The random effect model was used to calculate the combined effect, the weighted mean differences (WMDs) and its 95 % confidence interval (CI). Purslane supplementation significantly reduced fasting blood glucose (FBG) levels (WMD: −15.01; 95 % CI: −25.31, −4.71, p= 0.004), total cholesterol (TC) (WMD: −17.75; 95 % CI: −26.06, −9.45; p< 0.001), triglyceride (TG) (WMD: −21.30; 95 % CI: −32.59, −10.00; p< 0.001), low-density lipoprotein cholesterol (LDL-C) (WMD: −6.10; 95 % CI: −9.52, −2.68; p< 0.001), and CRP levels (WMD: −1.44; 95 % CI: −2.25, −0.63; p< 0.001), and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 6.17; 95 % CI: 2.53, 9.80; p< 0.001). Also, purslane did not significant effect on serum levels of insulin, hemoglobin A1C (HbA1c), and homeostatic model Assessment for insulin resistance (HOMA-IR). The results of our study showed that purslane supplementation improved FBG, and lipid profile levels, but did not affect HOMA-IR, insulin, and HbA1c levels. However, high-quality trials are needed to approve our results.

尽管许多试验证明马齿苋对2型糖尿病（T2DM）患者有益，但一些研究结果却否定了这种作用。我们阐明了马齿苋对 T2DM 患者的 c 反应蛋白（CRP）、血脂状况和血糖控制的影响。我们在 Web of Sciences、Scopus、Cochrane Library、PubMed 和 Embase 上进行了系统检索，以确定从开始到 2024 年 2 月 10 日发表的研究。研究采用随机效应模型计算综合效应、加权平均差（WMD）及其95%置信区间（CI）。补充马齿苋可明显降低空腹血糖 (FBG) 水平（WMD：-15.01；95% CI：-25.31，-4.71，p= 0.004）、总胆固醇 (TC)（WMD：-17.75；95% CI：-26.06，-9.45；p< 0.001）、甘油三酯 (TG)（WMD：-21.30；95% CI：-32.59，-10.00；p< 0.001）、低密度脂蛋白胆固醇（LDL-C）（WMD：-6.10；95% CI：-9.52，-2.68；p< 0.001）和 CRP 水平（WMD：-1.44；95% CI：-2.25，-0.63；p< 0.001），并增加了高密度脂蛋白胆固醇（HDL-C）（WMD：6.17；95% CI：2.53，9.80；p< 0.001）。此外，马齿苋对血清中的胰岛素水平、血红蛋白A1C（HbA1c）和胰岛素抵抗的稳态模型评估（HOMA-IR）没有显著影响。我们的研究结果表明，补充马齿苋可改善血糖和血脂水平，但不会影响 HOMA-IR、胰岛素和 HbA1c 水平。然而，我们的研究结果还需要高质量的试验来验证。

{"title":"The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials","authors":"Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang","doi":"10.1016/j.prostaglandins.2024.106917","DOIUrl":"10.1016/j.prostaglandins.2024.106917","url":null,"abstract":"<div><div>Although numerous trials have demonstrated the benefits of purslane on patients with type 2 diabetes mellitus (T2DM), the results of some studies reject such effect. We elucidated the influence of purslane on c-reactive protein (CRP), lipid profile, and glycemic control in patients with T2DM. We conducted a systematic search on Web of Sciences, Scopus, the Cochrane Library, PubMed, and Embase, to identify studies published from their inception to February 10, 2024. The random effect model was used to calculate the combined effect, the weighted mean differences (WMDs) and its 95 % confidence interval (CI). Purslane supplementation significantly reduced fasting blood glucose (FBG) levels (WMD: −15.01; 95 % CI: −25.31, −4.71, p= 0.004), total cholesterol (TC) (WMD: −17.75; 95 % CI: −26.06, −9.45; p< 0.001), triglyceride (TG) (WMD: −21.30; 95 % CI: −32.59, −10.00; p< 0.001), low-density lipoprotein cholesterol (LDL-C) (WMD: −6.10; 95 % CI: −9.52, −2.68; p< 0.001), and CRP levels (WMD: −1.44; 95 % CI: −2.25, −0.63; p< 0.001), and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 6.17; 95 % CI: 2.53, 9.80; p< 0.001). Also, purslane did not significant effect on serum levels of insulin, hemoglobin A1C (HbA1c), and homeostatic model Assessment for insulin resistance (HOMA-IR). The results of our study showed that purslane supplementation improved FBG, and lipid profile levels, but did not affect HOMA-IR, insulin, and HbA1c levels. However, high-quality trials are needed to approve our results.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106917"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0