Prostaglandins & other lipid mediators最新文献_第3页

Exploring the Unique Role of Specialized Pro-Resolving Mediators in Cancer Therapeutics. 探索特殊促溶解介质在癌症治疗中的独特作用。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-12-23 DOI: 10.1016/j.prostaglandins.2024.106944

Katherine M Quinlivan, Isabella V Howard, Franciska Southan, Rachel L Bayer, Kimberly L Torres, Charles N Serhan, Dipak Panigrahy

Unresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and metastasis in various cancer types. In contrast to blocking inflammation, stimulation of resolution of inflammation is an entirely novel approach to "resolve" inflammation. Resolution of inflammation mechanisms in cancer includes clearance of tumor debris, counter-regulation of pro-inflammatory eicosanoids and cytokines, and suppression of leukocyte infiltration. Conventional cytotoxic chemotherapy, radiation, anti-angiogenic therapy, and immune checkpoint inhibitors directly or indirectly can lead to the generation of pro-tumorigenic cellular debris. Over the past two decades, a potential paradigm shift has emerged in the inflammation field with the discovery of specialized pro-resolving mediators (SPMs), including resolvins, lipoxins, maresins, and protectins. SPMs are structurally distinct families of mediators grouped together by their pro-resolving "debris-clearing" functions. "Pro-resolving" therapies are in clinical development for various inflammation-driven diseases, including cancer. SPMs, as novel cancer therapeutics, have tremendous potential to enhance current cancer therapy. The mechanisms of SPMs as anti-cancer therapeutics are under active investigation by various laboratories worldwide. Here, we explore the current appreciation of the SPMs as innovative potential treatments designed to harness the unique anti-cancer activity of SPMs.

未解决的慢性炎症是癌症的一个标志，在各种癌症类型中促进肿瘤生长和转移。与阻断炎症相比，刺激炎症消退是一种全新的“解决”炎症的方法。癌症炎症机制的解决包括清除肿瘤碎片，抗炎性类二十烷和细胞因子的调控，以及抑制白细胞浸润。传统的细胞毒性化疗、放疗、抗血管生成治疗和免疫检查点抑制剂可直接或间接导致促肿瘤细胞碎片的产生。在过去的二十年里，随着专门的促溶解介质（SPMs）的发现，炎症领域出现了潜在的范式转变，这些介质包括溶解蛋白、脂毒素、脂毒素和保护蛋白。spm是结构上不同的调解剂家族，根据其支持解决的“清理碎片”功能组合在一起。针对包括癌症在内的各种炎症性疾病，“促缓解”疗法正处于临床开发阶段。SPMs作为一种新型的癌症治疗药物，在加强当前癌症治疗方面具有巨大的潜力。SPMs作为抗癌药物的作用机制正受到世界各国实验室的积极研究。在这里，我们探讨了目前对SPMs作为创新潜在治疗方法的评价，旨在利用SPMs独特的抗癌活性。

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引用次数: 0

Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats 迷迭香酸可减轻高脂饮食致高胆固醇血症大鼠心脏异常

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-28 DOI: 10.1016/j.prostaglandins.2024.106936

R Sundaram , K Muthu

Hyperlipidemia is a well-known risk factor for atherosclerosis and subsequent atherosclerotic cardiovascular diseases that are associated with high morbidity and mortality in obese and diabetic patients worldwide. The current study looked on rosmarinic acid's cadioprotective effects in rats fed a high-fat diet as there was no study on this aspect. The rats were given a high-fat diet comprising of 84.3 % conventional laboratory rat chow, 5 % lard, 10 % egg yolk powder, 0.2 % cholesterol, and 0.5 % bile salt to produce hypercholesterolemia. Over a span of eight weeks. The plasma lipid profile, cardiac marker enzymes, membrane bound ATPases, lysosomal enzymes, CRP, fibrinogen, proinflammatory cytokines (IL-1β, IL-6,TNF-α, NF-κB),anti-inflammatory cytokine(IL-10) lipid peroxidation markers, enzymatic and non-enzymatic antioxidant enzymes activity were examined. The thoracic aorta's histopathology was also analyzed. It was discovered that the rats fed a high-fat diet had hypercholesterolemia and showed aberrant values in the aforementioned parameters. However, rats given rosmarinic acid (100 mg/kg b.w.) had these anomalies reversed to near-normal levels. The biochemical investigation was corroborated by enhanced histological examination of the thoracic aorta in rats suffering from hypercholestolemia. The effects of rosmarinic acid on a number of measures were similar to those of the prescription medication simvastatin. These findings revealed that rosmarinic acid is an important component in the cardiovascular system's defence against a high-fat diet induced hypercholesterolemia

高脂血症是动脉粥样硬化和随后的动脉粥样硬化性心血管疾病的一个众所周知的危险因素，与世界范围内肥胖和糖尿病患者的高发病率和死亡率有关。目前的研究着眼于迷迭香酸对高脂肪饮食大鼠的心脏保护作用，因为没有这方面的研究。给大鼠喂食高脂肪饮食，其中包括84.3 %常规实验室大鼠饲料，5 %猪油，10 %蛋黄粉，0.2 %胆固醇和0.5 %胆汁盐，以产生高胆固醇血症。在八周的时间里。检测血脂谱、心脏标志物酶、膜结合atp酶、溶酶体酶、CRP、纤维蛋白原、促炎细胞因子（IL-1β、IL-6、TNF-α、NF-κB）、抗炎细胞因子（IL-10）脂质过氧化标志物、酶和非酶抗氧化酶活性。同时对胸主动脉组织病理学进行分析。研究发现，喂食高脂肪食物的大鼠出现高胆固醇血症，上述参数值出现异常。然而，给大鼠迷迭香酸（100 mg/kg b.w.）后，这些异常恢复到接近正常水平。高胆固醇血症大鼠的胸主动脉强化组织学检查证实了生化调查。迷迭香酸对多项指标的影响与处方药物辛伐他汀相似。这些发现表明迷迭香酸是心血管系统防御高脂肪饮食引起的高胆固醇血症的重要成分

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引用次数: 0

Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis 补充葡萄糖甘露聚糖是否会对成人血清脂质状况产生有利影响？系统回顾和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-09 DOI: 10.1016/j.prostaglandins.2024.106934

Zhu Haijun , Zhang Ke , Zhang Dawei , Amir Reza Haedi , Elika Poorasadollah , Cheng Cheng

Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: −2.26; 95 % CI: −2.98, −1.55, p <0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: −2.57; 95 % CI: −3.41, −1.74; p<0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: −0.33; 95 % CI: −0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: −0.16; 95 % CI: −0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.

考虑到血脂异常对心血管疾病甚至慢性疾病的影响，以及葡甘聚糖对血脂异常的有益作用，本研究旨在深入研究葡甘聚糖如何影响血脂谱参数。本研究使用标准关键词，在 Scopus、PubMed、Embase、Web of Science 数据库和 Google Scholar 等数据库中检索了从开始到 2024 年 12 月的所有研究。研究发现，葡甘聚糖能显著降低总胆固醇（TC）（SMD：-2.26；95% CI：-2.98，-1.55，p

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引用次数: 0

The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age "维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响"。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-11-08 DOI: 10.1016/j.prostaglandins.2024.106920

Juanjuan Zhu , Bingbing Wang , Sanaz Asemani , Shiwei Bao , Niannian Tian

Objective

The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children’s serum calcium, alkaline Phosphatase, and bone Age.

Methods

The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.

Results

Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P<0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.

Conclusion

The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.

研究目的研究旨在探讨维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响方法：研究分析了 159 名接受体检的学龄儿童的临床数据。根据儿童血清中 25- 羟基维生素 D3 的水平，将其分为 25-(OH)D3 缺乏组和非 25-(OH)D3 缺乏组。两组儿童的体重指数（BMI）、总胆固醇（TC）、总胆固醇（TG）、血糖（FBG）、糖化血红蛋白（HbA1c）、钙（Ca）、谷丙转氨酶（ALP）和骨龄差异进行了比较：结果：与缺乏 25-(OH)D3 的人相比，缺乏 25-(OH)D3 的人的 BMI、TC、TG 和 ALP 水平较高，而 Ca 和骨龄水平较低。这些差异具有统计学意义（PC结论：学龄儿童缺乏 25-(OH)D3 与肥胖有关，并影响骨骼生长。监测维生素 D 水平对临床医师至关重要。

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引用次数: 0

The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials 补充蜂胶对炎症生物标志物的影响：随机对照临床试验的荟萃分析和系统回顾

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-28 DOI: 10.1016/j.prostaglandins.2024.106915

LUO Zhong-yong , Deng ZHi-qing , Xia Li-qiong , Elika Poorasadollah , Shabnam Shirvani

Recent interventional investigations suggest the beneficial impact of propolis supplementation on inflammatory biomarkers; however, the results have not been summarized in a comprehensive meta-analysis. We conducted this meta-analysis to summarize all available data and provide clear evidence for whether propolis supplementation affects inflammatory biomarkers. This systematic review with meta-analysis was performed by searching databases (PubMed/Medline, Web of Science, Scopus, and Embase) until February 2024. It included randomized clinical trials (RCTs) assessing the effects of propolis supplementation on inflammatory biomarkers in adults. This review included 20 RCTs with a total of 1139 participants. The propolis supplementation significantly reduced IL-6 (WMD = −2.48; 95 % CI: −4.62, −0.34; P = 0.023) and TNF-α (WMD = −0.86; 95 % CI: −1.45, −0.26; P = 0.005) compared with control groups. Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: −0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks. These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology. Due to the limited number of studies, clinical diversity, and other limitations, it is necessary to conduct more high-quality studies to provide more precise and comprehensive recommendations.

最近的干预性研究表明，补充蜂胶对炎症生物标志物有有益影响；然而，这些结果尚未在一项全面的荟萃分析中得到总结。我们进行了这项荟萃分析，以总结所有可用数据，为蜂胶补充剂是否影响炎症生物标志物提供明确证据。本系统综述和荟萃分析是通过检索数据库（PubMed/Medline、Web of Science、Scopus 和 Embase）进行的，检索期截至 2024 年 2 月。研究纳入了评估蜂胶补充剂对成人炎症生物标志物影响的随机临床试验（RCT）。该综述包括20项随机临床试验，共有1139人参与。与对照组相比，补充蜂胶可明显降低IL-6（WMD = -2.48；95 % CI：-4.62，-0.34；P = 0.023）和TNF-α（WMD = -0.86；95 % CI：-1.45，-0.26；P = 0.005）。虽然 CRP 浓度没有降低（WMD = 0.01；95 % CI：-0.03，0.05；P = 0.646），但补充时间≥ 10 周的 CRP 水平显著降低。这些结果表明，蜂胶对TNF-α和IL-6水平具有有益的影响，可作为一种有效的辅助疗法，用于治疗炎症是病因中关键因素的疾病。由于研究数量有限、临床多样性和其他局限性，有必要开展更多高质量的研究，以提供更准确、更全面的建议。

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引用次数: 0

The association between dietary inflammatory index with risk rheumatoid arthritis: A case-control study 膳食炎症指数与类风湿性关节炎之间的关系：一项病例对照研究。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106916

Zhejianyi Gao , Farhad Alishahi , Amirabbas Faridpour , Saeed Nezamoleslami , Shokufeh Nezamoleslami , Reza Ghiasvand , Ariyo Movahedi , Nitin Shivappa , James R. Hébert , Mahsa Jalalinejad , Asal Ataie-Jafari

Diet represents an important set of potential risk factors for rheumatoid arthritis (RA), a known inflammatory condition. This case-control study examined the association between the inflammatory potential of diet, as determined by the dietary inflammatory index (DII®), and RA risk in an Iranian population. The present Case–control study was conducted on 100 RA patients and 200 age- and sex-matched controls in Isfahan, Iran. The presence of RA was determined by expert Rheumatologist assessment based on the American College of Rheumatology definitions. A 168-item food frequency questionnaire was used to collect dietary intake from which DII scores were computed. Odds ratios (OR) and 95 % confidence intervals (CI) for the association between the DII, expressed in tertiles, and RA risk were estimated by two multivariable logistic regression models, one crude model and one in which we controlled for important potential confounders. In the crude model, individuals in the top DII tertile (most pro-inflammatory diet) had more than triple the risk of RA compared to those in the lowest tertile (OR_tertile3vs1= 3.57; 95 % CI, 1.95–6.53; p< 0.001). The association was essentially unchanged after controlling for potential confounders (OR _tertile3vs1 = 3.83; 95 % CI, 1.66–8.81; p<0.001). We found that a pro-inflammatory diet is associated with increased risk of RA. Higher volume studies are needed to confirm the results.

饮食是类风湿性关节炎（RA）的一组重要潜在风险因素，RA 是一种已知的炎症性疾病。这项病例对照研究考察了伊朗人群中饮食炎症指数（DII®）所确定的饮食炎症潜能与类风湿关节炎风险之间的关联。本病例对照研究的对象是伊朗伊斯法罕的 100 名 RA 患者和 200 名年龄和性别匹配的对照组。根据美国风湿病学会的定义，由风湿病专家进行评估，确定是否患有风湿性关节炎。研究人员使用了一份包含 168 个项目的食物频率问卷来收集饮食摄入量，并据此计算出 DII 分数。通过两个多变量逻辑回归模型（一个粗略模型和一个控制了重要潜在混杂因素的模型）估算了DII（以三等分表示）与RA风险之间的相关性的比率（OR）和95%置信区间（CI）。在粗略模型中，DII最高三分位数（最亲炎饮食）的人与最低三分位数的人相比，罹患RA的风险高出三倍多（ORtertile3vs1= 3.57；95% CI，1.95-6.53；p< 0.001）。在控制了潜在的混杂因素后，这种关联基本保持不变（OR tertile3vs1 = 3.83; 95% CI, 1.66-8.81; p

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引用次数: 0

Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation 选择性 mTORC2 抑制通过 IKKα/IκB-α/NF-κB 激活对 Zymosan 引起的低血压和全身炎症的保护作用。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106918

Zainab Sabrie , Meryem Temiz-Resitoglu , Taskin Kalkan , Banu Kilic , Bahar Tunctan , Kafait U. Malik , Seyhan Sahan-Firat

Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1) signaling pathway exerts potent anti-inflammatory activity, little is known about mTORC2’s contribution to non-septic shock. Thus, our research aims to investigate mTORC2's contribution and associated changes of IκB kinase (IKKα)/inhibitor κB (IκB-α)/nuclear factor-ĸB (NF-κB) pathway on Zymosan (ZYM)-induced non-septic rat model using the novel mTORC2 selective inhibitor JR-AB2–011. Rats were given saline (4 ml/kg), dimethylsulfoxide (DMSO) (4 ml/kg), ZYM (500 mg/kg), and (or) JR-AB2–011 (1 mg/kg). Mean arterial pressure (MAP) and heart rate (HR) of rats were recorded. JR-AB2–011 reversed both ZYM-induced reduction in MAP and increase in HR. Protein expression and/or phosphorylation of rictor, protein kinase B (Akt), IκB-α, IKKα, NF-κB p65, inducible nitric oxide synthase (iNOS), nitrotyrosine, cyclooxygenase 2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, besides prostaglandin (PG) E₂ levels were measured. The enhanced expression of the proteins mentioned above has been inhibited by JR-AB2–011. These data suggest mTORC2’s promising role in ZYM-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB pathway.

非败血症性休克是一种导致多器官功能障碍的严重疾病。尽管针对哺乳动物雷帕霉素靶标复合体 1（mTORC1）信号通路可发挥强效抗炎活性，但人们对 mTORC2 在非失血性休克中的作用知之甚少。因此，我们的研究旨在利用新型 mTORC2 选择性抑制剂 JR-AB2-011，研究 mTORC2 对齐莫散（ZYM）诱导的非败血症大鼠模型的贡献以及 IκB 激酶（IKKα）/抑制因子κB（IκB-α）/核因子ĸB（NF-κB）通路的相关变化。给大鼠注射生理盐水（4 毫升/千克）、二甲基亚砜（DMSO）（4 毫升/千克）、ZYM（500 毫克/千克）和（或）JR-AB2-011（1 毫克/千克）。记录大鼠的平均动脉压（MAP）和心率（HR）。JR-AB2-011 逆转了 ZYM 诱导的 MAP 降低和 HR 升高。对 rictor、蛋白激酶 B (Akt)、IκB-α、IKKα、NF-κB p65、诱导型一氧化氮合酶 (iNOS)、硝基酪氨酸、环氧化酶 2 (COX-2)、肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-1β 以及前列腺素 (PG) E2 水平的蛋白表达和/或磷酸化进行了测定。JR-AB2-011 可抑制上述蛋白的表达。这些数据表明，mTORC2 在通过 IKKα/IκB-α/NF-κB 通路介导的 ZYM 诱导的低血压和全身性炎症中发挥着重要作用。

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引用次数: 0

The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials 马齿苋对 2 型糖尿病患者 C 反应蛋白、血脂状况和血糖控制的影响：对随机对照试验进行 GRADE 评估的系统综述和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-23 DOI: 10.1016/j.prostaglandins.2024.106917

Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang

Although numerous trials have demonstrated the benefits of purslane on patients with type 2 diabetes mellitus (T2DM), the results of some studies reject such effect. We elucidated the influence of purslane on c-reactive protein (CRP), lipid profile, and glycemic control in patients with T2DM. We conducted a systematic search on Web of Sciences, Scopus, the Cochrane Library, PubMed, and Embase, to identify studies published from their inception to February 10, 2024. The random effect model was used to calculate the combined effect, the weighted mean differences (WMDs) and its 95 % confidence interval (CI). Purslane supplementation significantly reduced fasting blood glucose (FBG) levels (WMD: −15.01; 95 % CI: −25.31, −4.71, p= 0.004), total cholesterol (TC) (WMD: −17.75; 95 % CI: −26.06, −9.45; p< 0.001), triglyceride (TG) (WMD: −21.30; 95 % CI: −32.59, −10.00; p< 0.001), low-density lipoprotein cholesterol (LDL-C) (WMD: −6.10; 95 % CI: −9.52, −2.68; p< 0.001), and CRP levels (WMD: −1.44; 95 % CI: −2.25, −0.63; p< 0.001), and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 6.17; 95 % CI: 2.53, 9.80; p< 0.001). Also, purslane did not significant effect on serum levels of insulin, hemoglobin A1C (HbA1c), and homeostatic model Assessment for insulin resistance (HOMA-IR). The results of our study showed that purslane supplementation improved FBG, and lipid profile levels, but did not affect HOMA-IR, insulin, and HbA1c levels. However, high-quality trials are needed to approve our results.

尽管许多试验证明马齿苋对2型糖尿病（T2DM）患者有益，但一些研究结果却否定了这种作用。我们阐明了马齿苋对 T2DM 患者的 c 反应蛋白（CRP）、血脂状况和血糖控制的影响。我们在 Web of Sciences、Scopus、Cochrane Library、PubMed 和 Embase 上进行了系统检索，以确定从开始到 2024 年 2 月 10 日发表的研究。研究采用随机效应模型计算综合效应、加权平均差（WMD）及其95%置信区间（CI）。补充马齿苋可明显降低空腹血糖 (FBG) 水平（WMD：-15.01；95% CI：-25.31，-4.71，p= 0.004）、总胆固醇 (TC)（WMD：-17.75；95% CI：-26.06，-9.45；p< 0.001）、甘油三酯 (TG)（WMD：-21.30；95% CI：-32.59，-10.00；p< 0.001）、低密度脂蛋白胆固醇（LDL-C）（WMD：-6.10；95% CI：-9.52，-2.68；p< 0.001）和 CRP 水平（WMD：-1.44；95% CI：-2.25，-0.63；p< 0.001），并增加了高密度脂蛋白胆固醇（HDL-C）（WMD：6.17；95% CI：2.53，9.80；p< 0.001）。此外，马齿苋对血清中的胰岛素水平、血红蛋白A1C（HbA1c）和胰岛素抵抗的稳态模型评估（HOMA-IR）没有显著影响。我们的研究结果表明，补充马齿苋可改善血糖和血脂水平，但不会影响 HOMA-IR、胰岛素和 HbA1c 水平。然而，我们的研究结果还需要高质量的试验来验证。

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引用次数: 0

Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials 陈年大蒜提取物对高血压患者血压的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-20 DOI: 10.1016/j.prostaglandins.2024.106914

Mohamed J. Saadh , Muthena Kariem , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Shirin Hasaanzadeh

Background

There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients.

Methods

We searched English web databases including, PubMed, Scopus, Embase, Web of Science until August 2024. Random-effects meta-analysis was used to pool weighted mean differences (WMD) and 95 % CI for the outcomes.

Results

Overall, nine RCTs with584 participants met inclusion criteria. AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: −4.03; %95CI: −6.87, −1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: −1.44; 95 % CI= −2.87, −0.02; P = 0.052; I²: 36.8 %; P: 0.105). Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.

Conclusion

The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day. To confirm these results, well-designed future trials will be needed.

背景：关于陈年大蒜提取物（AGE）对血压的影响，现有文献尚未达成共识。本系统综述和荟萃分析旨在综合现有随机临床试验（RCTs）中关于补充 AGE 对高血压患者血压影响的数据：我们检索了截至 2024 年 8 月的英文网络数据库，包括 PubMed、Scopus、Embase 和 Web of Science。采用随机效应荟萃分析法汇集结果的加权平均差（WMD）和 95% CI：共有9项研究符合纳入标准，584人参与研究。补充 AGE 茶可降低收缩压（SBP）（WMD：-4.03；95%CI：-6.87，-1.20；I2：57.1%）和舒张压（DBP）（WMD：-1.44；95%CI=-2.87，-0.02；P=0.052；I2：36.8%；P：0.105）。此外，亚组分析表明，高血压患者补充较高剂量的 AGE 可显著降低 DBP 和 SBP：本研究结果表明，AGE补充剂可能有益于改善高血压患者的血压，但只有在剂量超过1200毫克/天时才能观察到明显效果。要证实这些结果，还需要今后进行精心设计的试验。

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引用次数: 0

Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis 维生素 D 补充剂对多囊卵巢综合征患者血脂和荷尔蒙功能的影响：总括性系统综述和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-09 DOI: 10.1016/j.prostaglandins.2024.106913

Tong Yin , Weixiong Lin , Kangwen Ming , Hnag Lv , Yinxin Wang , LI Yuanchao , Hao Zhen , Junyun Yuan , Hassan Asadi

Vitamin D has the potential to therapeutically affect the lipid profile and endocrine parameters of polycystic ovary syndrome (PCOS) patients. However, results from prior studies have been inconsistent. Therefore, we conducted an umbrella meta-analysis of randomized controlled trials (RCTs) to better understand the effectiveness of vitamin D in treating PCOS. We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and Scopus, from their inception to January 2, 2024. Random-effects models were used to perform the umbrella meta-analysis. The analysis included 15 meta-analyses of RCTs. Vitamin D demonstrated a significant reduction in TG levels (SMD = -0.23; 95 % CI: −0.42, −0.04, p = 0.02, and WMD = −8.76, 95 % CI: −11.81, −5.72; p <0.001), TC (SMD = −0.47, 95 % CI: −0.80, −0.13; p = 0.007, and WMD = −8.89, 95 % CI: −13.18, −4.59; p < 0.001), LDL-c (SMD = −0.24, 95 % CI: −0.38, −0.10; p = 0.001, and WMD = −3.83, 95 % CI: −6.49, −1.16; p = 0.005), TT (SMD = −0.15, 95 % CI: −0.29 to −0.01; p = 0.02), and DHEA (WMD: −28.03; 95 % CI: −56.9 to −0.36; p = 0.04). However, no significant effect on HDL-c, insulin, and BMI. The present meta-analysis revealed that vitamin D supplementation might significantly affect TG, TC, LDL-c, DHEA, and TT while it is not effective in improving BMI, HDL-c, and insulin. Vitamin D showed noteworthy effects in preventing lipid profile and enhancing hormonal function in patients with PCOS.

维生素 D 有可能对多囊卵巢综合症（PCOS）患者的血脂状况和内分泌参数产生治疗性影响。然而，之前的研究结果并不一致。因此，我们对随机对照试验（RCTs）进行了总括荟萃分析，以更好地了解维生素 D 治疗多囊卵巢综合征的效果。我们在多个数据库（包括 Embase、PubMed、Web of Science、Cochrane CENTRAL 和 Scopus）中进行了电子检索，检索时间从开始到 2024 年 1 月 2 日。采用随机效应模型进行总体荟萃分析。分析包括 15 项研究性临床试验的荟萃分析。维生素 D 能显著降低 TG 水平（SMD = -0.23；95% CI：-0.42，-0.04，p = 0.02；WMD = -8.76，95% CI：-11.81，-5.72；p = 0.05）。

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