Prostaglandins & other lipid mediators最新文献_第3页

Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials 陈年大蒜提取物对高血压患者血压的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-20 DOI: 10.1016/j.prostaglandins.2024.106914

Mohamed J. Saadh , Muthena Kariem , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Shirin Hasaanzadeh

Background

There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients.

Methods

We searched English web databases including, PubMed, Scopus, Embase, Web of Science until August 2024. Random-effects meta-analysis was used to pool weighted mean differences (WMD) and 95 % CI for the outcomes.

Results

Overall, nine RCTs with584 participants met inclusion criteria. AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: −4.03; %95CI: −6.87, −1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: −1.44; 95 % CI= −2.87, −0.02; P = 0.052; I²: 36.8 %; P: 0.105). Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.

Conclusion

The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day. To confirm these results, well-designed future trials will be needed.

背景：关于陈年大蒜提取物（AGE）对血压的影响，现有文献尚未达成共识。本系统综述和荟萃分析旨在综合现有随机临床试验（RCTs）中关于补充 AGE 对高血压患者血压影响的数据：我们检索了截至 2024 年 8 月的英文网络数据库，包括 PubMed、Scopus、Embase 和 Web of Science。采用随机效应荟萃分析法汇集结果的加权平均差（WMD）和 95% CI：共有9项研究符合纳入标准，584人参与研究。补充 AGE 茶可降低收缩压（SBP）（WMD：-4.03；95%CI：-6.87，-1.20；I2：57.1%）和舒张压（DBP）（WMD：-1.44；95%CI=-2.87，-0.02；P=0.052；I2：36.8%；P：0.105）。此外，亚组分析表明，高血压患者补充较高剂量的 AGE 可显著降低 DBP 和 SBP：本研究结果表明，AGE补充剂可能有益于改善高血压患者的血压，但只有在剂量超过1200毫克/天时才能观察到明显效果。要证实这些结果，还需要今后进行精心设计的试验。

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引用次数: 0

Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis 维生素 D 补充剂对多囊卵巢综合征患者血脂和荷尔蒙功能的影响：总括性系统综述和荟萃分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-10-09 DOI: 10.1016/j.prostaglandins.2024.106913

Tong Yin , Weixiong Lin , Kangwen Ming , Hnag Lv , Yinxin Wang , LI Yuanchao , Hao Zhen , Junyun Yuan , Hassan Asadi

Vitamin D has the potential to therapeutically affect the lipid profile and endocrine parameters of polycystic ovary syndrome (PCOS) patients. However, results from prior studies have been inconsistent. Therefore, we conducted an umbrella meta-analysis of randomized controlled trials (RCTs) to better understand the effectiveness of vitamin D in treating PCOS. We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and Scopus, from their inception to January 2, 2024. Random-effects models were used to perform the umbrella meta-analysis. The analysis included 15 meta-analyses of RCTs. Vitamin D demonstrated a significant reduction in TG levels (SMD = -0.23; 95 % CI: −0.42, −0.04, p = 0.02, and WMD = −8.76, 95 % CI: −11.81, −5.72; p <0.001), TC (SMD = −0.47, 95 % CI: −0.80, −0.13; p = 0.007, and WMD = −8.89, 95 % CI: −13.18, −4.59; p < 0.001), LDL-c (SMD = −0.24, 95 % CI: −0.38, −0.10; p = 0.001, and WMD = −3.83, 95 % CI: −6.49, −1.16; p = 0.005), TT (SMD = −0.15, 95 % CI: −0.29 to −0.01; p = 0.02), and DHEA (WMD: −28.03; 95 % CI: −56.9 to −0.36; p = 0.04). However, no significant effect on HDL-c, insulin, and BMI. The present meta-analysis revealed that vitamin D supplementation might significantly affect TG, TC, LDL-c, DHEA, and TT while it is not effective in improving BMI, HDL-c, and insulin. Vitamin D showed noteworthy effects in preventing lipid profile and enhancing hormonal function in patients with PCOS.

维生素 D 有可能对多囊卵巢综合症（PCOS）患者的血脂状况和内分泌参数产生治疗性影响。然而，之前的研究结果并不一致。因此，我们对随机对照试验（RCTs）进行了总括荟萃分析，以更好地了解维生素 D 治疗多囊卵巢综合征的效果。我们在多个数据库（包括 Embase、PubMed、Web of Science、Cochrane CENTRAL 和 Scopus）中进行了电子检索，检索时间从开始到 2024 年 1 月 2 日。采用随机效应模型进行总体荟萃分析。分析包括 15 项研究性临床试验的荟萃分析。维生素 D 能显著降低 TG 水平（SMD = -0.23；95% CI：-0.42，-0.04，p = 0.02；WMD = -8.76，95% CI：-11.81，-5.72；p = 0.05）。

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引用次数: 0

Therapeutic potential of monoterpene molecules acts against 7KCh-mediated oxidative stress and neuroinflammatory amyloidogenic signalling pathways 单萜分子对 7KCh 介导的氧化应激和神经炎症性淀粉样蛋白生成信号通路具有治疗潜力。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-28 DOI: 10.1016/j.prostaglandins.2024.106910

Mahalakshmi Krishnan , Manikandan Kumaresan , Sangeetha Ravi , Livya Catherene Martin , Parimalanandhini Duraisamy , Beulaja Manikandan , Arumugam Munusamy , Manikandan Ramar

Alzheimer’s disease (AD) is a degenerative disorder characterised by amyloid-beta aggregates activated by the accumulation of lipid molecules and their derivatives, especially 7-ketocholesterol (7KCh), an oxidised lipid that plays a great part in the progression of AD. The current therapeutics need bio-potential molecules and their biomedical application preventing 7KCh-induced cytotoxicity. In this study, bornyl acetate (BA) and menthol (ME), the natural monoterpenes were investigated for their neuroprotective effects against 7KCh-induced SH-SY5Y cells and their effects were compared to the standard drug galantamine (GA). 7KCh-induced changes like lipid accumulation, amyloid generation, free radical generation, acetylcholinesterase levels, calcium accumulation and mitochondrial membrane integrity were analysed in SH-SY5Y cells with or without BA and ME treatment. Furthermore, various mediators involved in the amyloidogenic, inflammatory and apoptotic pathways were studied. In our results, the cells induced with 7KCh upon co-treatment with BA and ME significantly reduced lipid accumulation and amyloid generation through toll-like receptor (TLR) 4 suppression and enhanced ATP binding cassette (ABCA) 1-mediated clearance. Co-treatment with BA and ME concurrently regulated oxidative stress, acetylcholinesterase activity, mitochondrial membrane potential and intracellular calcification altered by 7KCh-induced SH-SY5Y cells. Moreover, 7KCh-induced cells showed elevated mRNA levels of misfolded protein markers and apoptotic mediators which were significantly downregulated by BA and ME co-treatment. In addition, the protein expression of amyloidogenic, proinflammatory as well as pro-apoptotic markers was decreased by BA and ME co-treatment in 7KCh-induced cells. Overall, BA and ME mediated inhibition of amyloidogenic activation and cell survival against 7KCh-induced inflammation, thereby preventing the onset and progression of AD in comparison to GA.

阿尔茨海默病（AD）是一种退行性疾病，其特征是脂质分子及其衍生物，特别是氧化脂质 7-酮胆固醇（7KCh）的积聚激活了淀粉样蛋白-β 聚集，在阿尔茨海默病的发展过程中起着重要作用。目前的疗法需要一种具有生物潜力的分子及其生物医学应用，以防止 7KCh 引起的细胞毒性。在这项研究中，研究了天然单萜类化合物醋酸硼酯（BA）和薄荷醇（ME）对 7KCh 诱导的 SH-SY5Y 细胞的神经保护作用，并将它们的作用与标准药物加兰他敏（GA）进行了比较。研究分析了经 BA 和 ME 处理或未经 BA 和 ME 处理的 SH-SY5Y 细胞中 7KCh 诱导的变化，如脂质积累、淀粉样蛋白生成、自由基生成、乙酰胆碱酯酶水平、钙积累和线粒体膜完整性。此外，还研究了参与淀粉样蛋白生成、炎症和细胞凋亡途径的各种介质。我们的研究结果表明，用7KCh诱导的细胞经BA和ME联合处理后，通过抑制类毒素受体（TLR）4和提高ATP结合盒（ABCA）1介导的清除率，显著减少了脂质积累和淀粉样蛋白的生成。BA和ME同时处理可调节氧化应激、乙酰胆碱酯酶活性、线粒体膜电位和7KCh诱导的SH-SY5Y细胞所改变的细胞内钙化。此外，7KCh 处理的细胞显示错误折叠蛋白标记物和凋亡介质的 mRNA 水平升高，而 BA 和 ME 联合处理的细胞则显著降低了这些标记物和介质的 mRNA 水平。此外，BA 和 ME 联合处理 7KCh 诱导的细胞后，淀粉样蛋白、促炎症和促凋亡标志物的蛋白表达也有所下降。总之，BA 和 ME 可抑制淀粉样蛋白的活化，并使细胞存活，从而对抗 7KCh 诱导的炎症。此外，与GA相比，BA和ME在预防AD的发生和发展方面可能具有更好的效果。

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引用次数: 0

The effect of raloxifene supplementation on blood pressure and Apo-lipoproteins in postmenopausal women: A systematic review and meta-analysis 补充雷洛昔芬对绝经后妇女血压和载脂蛋白的影响：系统回顾与元分析》。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-27 DOI: 10.1016/j.prostaglandins.2024.106912

Nooshin Noshadi , Atefeh Bonyadian , Salehe Zarian , Fatemeh Kazemi , Melika Darzi , Farzaneh Akhavan Tabib , Mahdieh Abbasalizad-Farhangi , Beitullah Alipour , Sarehnaz Aghili

Introduction

Several studies indicated the ameliorating effects of raloxifene supplementation on apolipoproteins and blood pressure, although others have conflicting findings. Therefore, the present study was conducted in order to accurately and definitively understands the effect of raloxifene on apolipoprotein AI (Apo-AI), apolipoprotein B (APoB), lipoprotein (a) (Lp (a)), systolic blood pressure (SBP) and diastolic blood pressure (DBP) in postmenopausal women.

Methods

A systematic literature search was conducted using scientific databases including PubMed, Scopus, Embase, and Web of Science and the Cochrane Library, through May 2024. The quality of studies was assessed using Cochrane tool. Random-effects meta-analysis was used to pool standardized mean differences (SMD) and 95 % CI for the outcomes.

Results

Twenty trials, with interventions ranging from 6 to 144 weeks and 2825 participants, were included. Raloxifene supplementation demonstrated significant reductions in ApoB (SMD: −0.92; 95 % CI: −1.49 to −0.35; P = 0.001), and Lp (a) (SMD: −0.25; 95 % CI: −0.39 to −0.11; P < 0.001) while increasing Apo-AI levels (SMD: 0.29; 95 % CI: 0.22–0.36; P < 0.001). Conversely, no significant effects were observed on SBP (WMD: −0.49 mmHg; 95 % CI: −3.01–2.04; P = 0.706), and DBP (WMD: −0.81 mmHg; 95 % CI: −4.04–2.41; P = 0.621). Moreover, subgroup analysis indicated that raloxifene significantly decreased DBP in studies with intervention durations of >12 weeks.

Conclusions

This meta-analysis has shown that raloxifene supplementation may have beneficial effects on apolipoproteins in postmenopausal women. Future studies are needed to investigate the effect of raloxifene on health status in in postmenopausal women.

介绍：多项研究表明，补充雷洛昔芬可改善脂蛋白和血压，但其他研究结果却相互矛盾。因此，本研究旨在准确、明确地了解雷洛昔芬对绝经后妇女的载脂蛋白 AI（Apo-AI）、载脂蛋白 B（APoB）、脂蛋白（a）（Lp（a））、收缩压（SBP）和舒张压（DBP）的影响：利用科学数据库（包括 PubMed、Scopus、Embase、Web of Science 和 Cochrane 图书馆）进行了系统性文献检索，检索期至 2024 年 5 月。研究质量采用 Cochrane 工具进行评估。随机效应荟萃分析用于汇集结果的标准化均值差异（SMD）和 95% CI：共纳入了 20 项试验，干预时间从 6 周到 144 周不等，共有 2825 名参与者。雷洛昔芬补充剂可显著降低载脂蛋白B（SMD：-0.92；95% CI：-1.49至-0.35；P = 0.001）和脂蛋白（a）（SMD：-0.25；95% CI：-0.39至-0.11；P <0.001），同时提高载脂蛋白AI水平（SMD：0.29；95% CI：0.22至0.36；P <0.001）。相反，对 SBP（WMD：-0.49mmHg；95% CI：-3.01 至 2.04；P = 0.706）和 DBP（WMD：-0.81mmHg；95% CI：-4.04 至 2.41；P = 0.621）未观察到明显影响。此外，亚组分析表明，在干预时间超过12周的研究中，雷洛昔芬能显著降低DBP：这项荟萃分析表明，补充雷洛昔芬可对绝经后妇女的脂蛋白产生有益影响。今后还需要开展研究，探讨雷洛昔芬对绝经后妇女健康状况的影响。

{"title":"The effect of raloxifene supplementation on blood pressure and Apo-lipoproteins in postmenopausal women: A systematic review and meta-analysis","authors":"Nooshin Noshadi , Atefeh Bonyadian , Salehe Zarian , Fatemeh Kazemi , Melika Darzi , Farzaneh Akhavan Tabib , Mahdieh Abbasalizad-Farhangi , Beitullah Alipour , Sarehnaz Aghili","doi":"10.1016/j.prostaglandins.2024.106912","DOIUrl":"10.1016/j.prostaglandins.2024.106912","url":null,"abstract":"<div><h3>Introduction</h3><div>Several studies indicated the ameliorating effects of raloxifene supplementation on apolipoproteins and blood pressure, although others have conflicting findings. Therefore, the present study was conducted in order to accurately and definitively understands the effect of raloxifene on apolipoprotein AI (Apo-AI), apolipoprotein B (APoB), lipoprotein (a) (Lp (a)), systolic blood pressure (SBP) and diastolic blood pressure (DBP) in postmenopausal women.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using scientific databases including PubMed, Scopus, Embase, and Web of Science and the Cochrane Library, through May 2024. The quality of studies was assessed using Cochrane tool. Random-effects meta-analysis was used to pool standardized mean differences (SMD) and 95 % CI for the outcomes.</div></div><div><h3>Results</h3><div>Twenty trials, with interventions ranging from 6 to 144 weeks and 2825 participants, were included. Raloxifene supplementation demonstrated significant reductions in ApoB (SMD: −0.92; 95 % CI: −1.49 to −0.35; P = 0.001), and Lp (a) (SMD: −0.25; 95 % CI: −0.39 to −0.11; P < 0.001) while increasing Apo-AI levels (SMD: 0.29; 95 % CI: 0.22–0.36; P < 0.001). Conversely, no significant effects were observed on SBP (WMD: −0.49 mmHg; 95 % CI: −3.01–2.04; P = 0.706), and DBP (WMD: −0.81 mmHg; 95 % CI: −4.04–2.41; P = 0.621). Moreover, subgroup analysis indicated that raloxifene significantly decreased DBP in studies with intervention durations of >12 weeks.</div></div><div><h3>Conclusions</h3><div>This meta-analysis has shown that raloxifene supplementation may have beneficial effects on apolipoproteins in postmenopausal women. Future studies are needed to investigate the effect of raloxifene on health status in in postmenopausal women.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106912"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential benefit of Lactobacillus acidophilus supplementation to rats fed with a high-fat diet on serum lipid profile, kidney amyloid protein and tumor necrosis factor-alpha level 高脂饮食大鼠补充嗜酸乳杆菌对血清脂质、肾淀粉样蛋白和肿瘤坏死因子-α水平的潜在益处

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-23 DOI: 10.1016/j.prostaglandins.2024.106911

Pınar Kar , Gülay Çiftci , Alper Çiftci

Aim

It was aimed to determine the potential effect of Lactobacillus acidophilus supplementation on rats exposed to an experimental high-fat diet on serum lipid profile and kidney total beta amyloid protein (TBAP) and Tumor Necrosis Factor-alpha (TNF-α) levels.

Methods

24 male Sprague-Dawley rats were used in the study to establish 4 groups. Standard rat food (SD) was provided to Group 1 as the control; Group 2 was fed a high-fat diet (HFD); Group 3 consumed SD and received L. acidophilus probiotics; Group 4 was fed HFD and received L. acidophilus probiotics. Body weights were determined weekly during the 12-week trial period. At the end of the experiment, TBP and TNF-α levels in the serum and kidney tissue of the rats were measured by ELISA method. Serum total cholesterol (TC), triglyceride (TG), HDL, LDL, urea and creatinine levels and paraoxanase, amylase and lipase activities were determined by spectrophotometric method on the analyzer device.

Results

When the control (Group 1) group and Group 2 were compared at the end of the experiment, it was found that Group 2 had gained the most weight and that both the blood and kidney tissue levels of TNF-α and TBAP, as well as the quantities of TG, TK, LDL, and urea, were significantly greater (P<0.05). Serum HDL, PON and amylase levels were found to be significantly low (P>0.05). TG, TK, LDL, urea, and the levels of TNF-α and TBAP in serum and renal tissue were shown to be lower in the groups who received L. acidophilus probiotics (Groups 3, 4) when compared to Group 2 (P>0.05). It was observed that HDL, PON and amylase levels increased and approached the control group (P<0.05).

Conclusion

The study's findings showed that probiotic supplementation improved blood levels of TG, TC, HDL, LDL, urea, PON, and amylase as well as serum and kidney tissue levels of TNF-α and TBAP in obese rats fed a high-fat diet.

目的：本研究旨在确定补充嗜酸乳杆菌对暴露于实验性高脂饮食的大鼠血清脂质概况、肾脏总β淀粉样蛋白（TBAP）和肿瘤坏死因子-α（TNF-α）水平的潜在影响。第 1 组以标准大鼠食物（SD）作为对照；第 2 组喂食高脂肪食物（HFD）；第 3 组喂食标准大鼠食物并摄入嗜酸乳杆菌益生菌；第 4 组喂食高脂肪食物并摄入嗜酸乳杆菌益生菌。在为期 12 周的试验期间，每周测定一次体重。实验结束时，采用 ELISA 方法测定大鼠血清和肾组织中的 TBP 和 TNF-α 水平。血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、尿素和肌酐水平，以及副氧杂环戊烷酶、淀粉酶和脂肪酶活性均通过分析仪上的分光光度法进行测定：实验结束后，对比对照组（第1组）和第2组，发现第2组体重增加最多，血液和肾组织中TNF-α和TBAP的含量以及TG、TK、LDL和尿素的含量均显著增加（P0.05）。与第 2 组相比，服用嗜酸乳杆菌益生菌组（第 3、4 组）的 TG、TK、LDL、尿素以及血清和肾组织中 TNF-α 和 TBAP 的含量均较低（P>0.05）。据观察，HDL、PON 和淀粉酶水平有所上升，并接近对照组（PC结论：研究结果表明，补充益生菌可改善以高脂肪饮食喂养的肥胖大鼠血液中的 TG、TC、HDL、LDL、尿素、PON 和淀粉酶水平，以及血清和肾组织中的 TNF-α 和 TBAP 水平。

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引用次数: 0

From tradition to science: Possible mechanisms of ghee in supporting bone and joint health 从传统到科学：酥油支持骨骼和关节健康的可能机制。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-21 DOI: 10.1016/j.prostaglandins.2024.106902

Maryam Falahatzadeh , Kianoosh Najafi , Kaveh Bashti

Ghee, a traditional form of clarified butter, has been used for centuries in Ayurvedic medicine for its numerous health benefits. Recent scientific studies have begun to elucidate the molecular mechanisms by which ghee may support bone and joint health. This review explores the bioactive components of ghee, including short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), and fat-soluble vitamins (A, D, E, K2), and their potential therapeutic effects on bone density, joint lubrication, and inflammation. SCFAs in ghee can potentially improve joint lubrication and reduce inflammation. MCFAs and conjugated linoleic acid (CLA) exhibit anti-inflammatory properties, modulating cytokine production and oxidative stress pathways. Vitamins D and K2 in ghee can play potentially crucial roles in calcium metabolism and bone mineralization, while vitamin A supports immune regulation and cartilage health. This review integrates traditional knowledge with contemporary scientific research, highlighting the potential of ghee as a complementary therapy for conditions such as osteoporosis and arthritis. By understanding the molecular mechanisms involved, future studies can focus on this field to shed a light on different effects of ghee on bone and joint health.

酥油是一种传统形式的澄清黄油，几个世纪以来一直被阿育吠陀医学用于治疗各种健康问题。最近的科学研究已开始阐明酥油支持骨骼和关节健康的分子机制。本综述探讨了酥油中的生物活性成分，包括短链脂肪酸（SCFA）、中链脂肪酸（MCFA）和脂溶性维生素（A、D、E、K2），以及它们对骨密度、关节润滑和炎症的潜在治疗作用。酥油中的 SCFA 有可能改善关节润滑和减轻炎症。MCFAs和共轭亚油酸（CLA）具有抗炎特性，可调节细胞因子的产生和氧化应激途径。酥油中的维生素 D 和 K2 可在钙代谢和骨矿化中发挥潜在的关键作用，而维生素 A 则有助于免疫调节和软骨健康。这篇综述将传统知识与当代科学研究相结合，强调了酥油作为骨质疏松症和关节炎等疾病的辅助疗法的潜力。通过了解其中涉及的分子机制，未来的研究可以聚焦这一领域，揭示酥油对骨骼和关节健康的不同影响。

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引用次数: 0

The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials 奇异籽对糖尿病、血压、血脂和肥胖指标的影响：对 14 项随机对照试验的系统回顾和元回归分析。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-19 DOI: 10.1016/j.prostaglandins.2024.106907

Hawal Lateef Fateh , Dyari H. Ahmed , Maryam Sharifi Najafabadi , Jalal Moludi

This comprehensive systematic review and meta-analysis sought to investigate the impact of chia seed supplementation on obesity indicators and metabolic factors. Through a thorough search of relevant studies up to April 2024, 14 clinical trials involving 835 participants were included in the analysis. The findings revealed a notable decrease in triglyceride levels across both higher and lower doses of chia seeds, with weighted mean differences (WMD) of −8.69 mg/dL and −13.11 mg/dL, respectively. Additionally, a statistically significant reduction in LDL-C levels was observed solely in the higher dosage group, showing a WMD of −4.77 mg/dL. Moreover, although the decrease in systolic blood pressure (-2.78 mmHg) compared to the control group was statistically significant, it was only observed with the higher dosage. These results suggest that chia supplementation may offer beneficial effects on dyslipidemia, hypertension, and body weight, potentially mitigating the risk of cardiovascular disease.

这项全面的系统综述和荟萃分析旨在研究补充奇异籽对肥胖指标和代谢因素的影响。通过对截至 2024 年 4 月的相关研究进行全面搜索，14 项涉及 835 名参与者的临床试验被纳入分析范围。研究结果显示，较高和较低剂量的奇异籽都能显著降低甘油三酯水平，加权平均差（WMD）分别为-8.69毫克/分升和-13.11毫克/分升。此外，只有高剂量组的低密度脂蛋白胆固醇（LDL-C）水平出现了统计学意义上的显著降低，加权平均差（WMD）为-4.77毫克/分升。此外，虽然与对照组相比，收缩压的降低（-2.78mmHg）具有统计学意义，但这只在高剂量组中观察到。这些结果表明，补充奇异果可能会对血脂异常、高血压和体重产生有益的影响，从而有可能降低心血管疾病的风险。

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引用次数: 0

Yanghe Decoction promotes ferroptosis through PPARγ-dependent autophagy to inhibit the malignant progression of triple-negative breast cancer 洋河煎剂通过PPARγ依赖性自噬促进铁变态反应，抑制三阴性乳腺癌的恶性进展

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-14 DOI: 10.1016/j.prostaglandins.2024.106909

YangZi Cheng, GuiPing Yu, Chen Du, ZhaoHui Chen, XuFeng Liu

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Yanghe Decoction (YHD) has been used in the treatment of breast cancer for many years. We aimed to explore the effects of YHD on the malignant phenotypes of MDA-MB-231 cells and the potential mechanism related to PPARγ, autophagy and ferroptosis. The serum of rat containing different concentrations of YHD were collected to culture MDA-MB-231 cells. Cell viability and proliferation were assessed by the CCK-8 assay and EDU staining. Wound healing- and transwell assays were used to detect the capacities of MDA-MB-231 cell migration and invasion. Additionally, the levels of lipid peroxidation, Fe²⁺ and the expression of ferroptosis-related proteins were evaluated. The expression of PPARγ and autophagy-related proteins was assessed using immunofluorescence staining or western blot assay. Then, the PPARγ inhibitor (GW9662), autophagy inhibitor (3-MA) and autophagy inducer (rapamycin; Rap) were used to further study the potential mechanism of YHD on TNBC. Results indicated that contained-YHD serum significantly decreased the viability, proliferation, migration and invasion of TNBC cells. Moreover, YHD promoted lipid peroxidation level, elevated Fe²⁺ content and downregulated GPX4, SLC7A11 and SLC3A2 expression. Besides, autophagy was induced and PPARγ was upregulated by YHD in MDA-MB-231 cells. Furthermore, GW9662 alleviated the impacts of YHD on autophagy of MDA-MB-231 cells. Rap reversed the effects of GW9662 on lipid peroxidation, ferroptosis, proliferation, migration and invasion of MDA-MB-231 cells. 3-MA had the similar effects to GW9662. Collectively, YHD suppressed the malignant progression of MDA-MB-231 cells by inducing ferroptosis through PPARγ-dependent autophagy.

三阴性乳腺癌（TNBC）是乳腺癌的一种异质性亚型，具有高度侵袭性，预后较差。多年来，洋河煎剂一直被用于治疗乳腺癌。我们的目的是探讨洋河提取物对MDA-MB-231细胞恶性表型的影响，以及与PPARγ、自噬和铁变态相关的潜在机制。采集含有不同浓度YHD的大鼠血清培养MDA-MB-231细胞。细胞活力和增殖通过 CCK-8 检测法和 EDU 染色法进行评估。伤口愈合和透孔试验用于检测 MDA-MB-231 细胞的迁移和侵袭能力。此外，还评估了脂质过氧化、Fe2+ 和铁变态反应相关蛋白的表达水平。PPARγ 和自噬相关蛋白的表达采用免疫荧光染色法或 Western 印迹法进行评估。然后，使用 PPARγ 抑制剂（GW9662）、自噬抑制剂（3-MA）和自噬诱导剂（雷帕霉素；Rap）进一步研究 YHD 对 TNBC 的潜在作用机制。结果表明，含YHD血清可显著降低TNBC细胞的活力、增殖、迁移和侵袭。此外，YHD还能促进脂质过氧化水平，升高Fe2+含量，下调GPX4、SLC7A11和SLC3A2的表达。此外，YHD 还诱导了 MDA-MB-231 细胞的自噬，并上调了 PPARγ。此外，GW9662 可减轻 YHD 对 MDA-MB-231 细胞自噬的影响。Rap 逆转了 GW9662 对 MDA-MB-231 细胞脂质过氧化、铁变态反应、增殖、迁移和侵袭的影响。3-MA 的作用与 GW9662 相似。总之，YHD 通过 PPARγ 依赖性自噬诱导铁变态反应，从而抑制了 MDA-MB-231 细胞的恶性发展。

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引用次数: 0

The effects of selenium supplementation on lipid profile in adults: A systematic review and meta-analysis of randomized controlled trials 补硒对成人血脂的影响：随机对照试验的系统回顾和元分析》。

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-12 DOI: 10.1016/j.prostaglandins.2024.106901

Mohamed J. Saadh , Abdulrahman Qais Khaleel , Muna S. Merza , Halijah Hassan , Balvir S. Tomar , Manmeet Singh , Ambati Vijay Kumar , Shirin Hasaanzadeh

Introduction

Dyslipidemia with a considerable progression rate is a primary risk factor for CVDs if left untreated. Dietary interventions have explored the health influences of selenium on lipid profiles in adults, yet the findings remain contentious. This study seeks to determine if selenium supplementation can positively modify the lipid profile (total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL), and high-density lipoprotein cholesterol (HDL-C) in adults.

Methods

Using predefined keywords, we searched online databases, including Scopus, PubMed, Web of Science Core Collection, and Google Scholar, for relevant studies published from inception through July 2024. A random-effects meta-analysis was then employed to pool the weighted mean differences (WMD) and 95 % CI for outcomes assessed by a minimum of three studies.

Results

Initially 1205 studies were obtained out of which 25 RCTs were decided to be included for further analyses. Selenium supplementation reduced VLDL (WMD: −1.53; 95 % CI: −2.86, −0.20), but did not change TG (WMD: 1.12; 95 % CI: −4.51, 6.74), TC (WMD: −2.25; 95 % CI: −6.80, 2.29), LDL-C (WMD: 1.60; 95 % CI: −4.26, 7.46), and HDL-C levels (WMD: 0.98; 95 % CI: - 0.02, 1.98).

Conclusion

Our study showed significantly reduced VLDL but limited effects were observed in other lipid indexes. More extensive RCTs are required globally to achieve a holistic comprehension of the connection between selenium and lipid profile.

引言血脂异常如果不及时治疗，其恶化速度相当快，是心血管疾病的主要风险因素。膳食干预措施探讨了硒对成人血脂状况的健康影响，但研究结果仍存在争议。本研究旨在确定补硒是否能积极改变成年人的血脂状况（总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL）和高密度脂蛋白胆固醇（HDL-C））。方法使用预定义的关键词，我们搜索了在线数据库，包括 Scopus、PubMed、Web of Science Core Collection 和 Google Scholar，以查找从开始到 2024 年 7 月期间发表的相关研究。然后采用随机效应荟萃分析法对至少三项研究评估的结果的加权平均差（WMD）和 95% CI 进行汇总。补硒可降低 VLDL（WMD：-1.53；95% CI：-2.86，-0.20），但不会改变 TG（WMD：1.12；95% CI：-4.51，6.74）、TC（WMD：-2.25；95% CI：-6.80，2.29）、LDL-C（WMD：1.结论我们的研究显示 VLDL 显著降低，但对其他血脂指标的影响有限。要全面了解硒与血脂之间的关系，还需要在全球范围内开展更广泛的 RCT 研究。

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引用次数: 0

Protective role of TRPM7 knockdown in ulcerative colitis via blocking NLRP3 inflammasome-mediated pyroptosis 敲除 TRPM7 通过阻断 NLRP3 炎症体介导的脓毒症对溃疡性结肠炎的保护作用

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators

Pub Date : 2024-09-12 DOI: 10.1016/j.prostaglandins.2024.106904

Jinzhen Peng , Shuai Tang , Lifang Huang , Ye Fang

Transient receptor potential melastatin 7 (TRPM7) has been emerged as a potent drug target for immunomodulation with ion conductance and kinase activities. The research is projected to characterize the influences of TRPM7 on the course of ulcerative colitis (UC) and dissect the latent response mechanisms. The in vivo murine model and in vitro cell model of UC were both stimulated by DSS. RT-qPCR and western blotting tested the abundance of TRPM7. Colonic damage was estimated by Hematoxylin-eosin staining, calculation of colon length, measurement of DAI and MPO assay kit. CCK-8 method and TUNEL staining severally ascertained cell activity and apoptosis. ELISA method assayed the inflammatory levels and relevant assay kits determined oxidative stress levels. FITC-dextran flux, immunohistochemistry, TEER as well as western blotting evaluated intestinal barrier function. Immunofluorescence staining and western blotting appraised NLR family pyrin domain containing 3 (NLRP3)-dependent pyroptosis. Depleted TRPM7 retarded inflammation, oxidative damage as well as intestinal barrier damage both in vitro and in vivo. TRPM7 reduction repressed the pyroptosis mediated by NLRP3 inflammasome. NLRP3 agonist nigericin partly abolished the protection elicited by TRPM7 silencing against inflammation, oxidative damage as well as intestinal barrier damage in vitro. Collectively, TRPM7 deletion might possess the therapeutic potential in UC, the working mechanism of which might involve the inactivation of NLRP3-dependent pyroptosis.

瞬时受体电位美司他丁 7（TRPM7）具有离子传导和激酶活性，是一种有效的免疫调节药物靶标。该研究旨在阐明TRPM7对溃疡性结肠炎（UC）病程的影响，并剖析其潜伏反应机制。体内小鼠模型和体外 UC 细胞模型均受到 DSS 的刺激。RT-qPCR和Western印迹检测了TRPM7的丰度。通过血红素-伊红染色、结肠长度计算、DAI测量和MPO检测试剂盒评估结肠损伤。CCK-8 法和 TUNEL 染色法可确定细胞的活性和凋亡情况。ELISA 法检测炎症水平，相关检测试剂盒检测氧化应激水平。FITC-右旋糖酐通量、免疫组织化学、TEER 和 Western 印迹法评估了肠道屏障功能。免疫荧光染色和 Western 印迹分析评估了 NLR 家族含吡咯啉结构域 3（NLRP3）依赖性热变态反应。减少TRPM7可延缓体外和体内的炎症、氧化损伤以及肠屏障损伤。减少TRPM7可抑制NLRP3炎性体介导的裂解。NLRP3激动剂尼格列汀在一定程度上取消了TRPM7沉默对体外炎症、氧化损伤和肠屏障损伤的保护作用。总之，TRPM7 基因缺失可能具有治疗 UC 的潜力，其工作机制可能涉及 NLRP3 依赖性热变态反应的失活。

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引用次数: 0