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Evaluation of metabolic control and chronic complications in a cohort of patients admitted to Braila County Emergency Hospital 巴西拉县急诊医院一组患者代谢控制和慢性并发症的评估
Pub Date : 2023-03-24 DOI: 10.37897/rmj.2023.1.2
Cristiana Voineag, G. Radulian, Bianca Demetra Postolache, Nicolae Popescu
In Romanian specialized literature, there is no national/regional registry that highlights the number of people with diabetes as well as the micro and macrovascular complications that affect the quality of life and lead to high economic costs. In this sense, the purpose of this study was to create a database to highlight essential variables according to demographic aspects, anthropometric indicators, glycosylated hemoglobin, chronic complications secondary to diabetes in order to define a profile of the diabetic patient and in the implementation of a early management algorithm in Braila County Hospital.
在罗马尼亚的专业文献中,没有一个国家/地区的登记,强调糖尿病患者的数量以及影响生活质量和导致高经济成本的微血管和大血管并发症。从这个意义上说,本研究的目的是创建一个数据库,根据人口统计学方面、人体测量指标、糖化血红蛋白、糖尿病继发慢性并发症来突出重要变量,以确定糖尿病患者的概况,并在Braila县医院实施早期管理算法。
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引用次数: 0
Bone marrow metastasis of breast cancer and chronic lymphocytic leukemia: A coincidence 乳腺癌和慢性淋巴细胞白血病的骨髓转移:巧合
Pub Date : 2023-03-24 DOI: 10.37897/rmj.2023.1.5
R. Cahyanur, A. Kosasih, L. Widjaja, Marini Stephanie, A. Harahap, Harits Adi Putra
Objectives. We present an extremely rare case of breast cancer with metastasis to the bone marrow, which was also simultaneously diagnosed with chronic lymphocytic leukemia (CLL). Case Presentation. A 56-year-old female with a history of routine blood transfusions presented with chronic fatigue and recurrent right upper quadrant abdominal pain due to cholecystitis. Additionally, nodules were palpable in both breasts, which were subsequently detected as suspicious calcified lesions on ultrasound. Leukocytosis and bi-cytopenia were found. Cholecystectomy was performed and biopsies from some tissues were conducted. Gall bladder and subcutaneous tissue from the umbilical area showed neoplastic cells suggestive of breast carcinoma. Bone marrow biopsy showed CLL and non-hematopoietic cells identical to the previously detected neoplastic cells. Immunohistochemistry revealed that the breast carcinoma was ER-positive, PR-positive, and HER2negative. Outcome. After a thorough investigation, the bone marrow depression was proven to result from a metastatic bone marrow lesion from breast cancer diagnosed concurrently with CLL. Conclusions. This circumstance obliged clinicians to be more considerate of the diagnostic approach and treatment of patients with neoplasm presenting with cytopenia. It is to avoid underdiagnosis and ensure that every pathology in the bone marrow is investigated and managed accordingly.
目标。我们报告一例极为罕见的乳腺癌骨髓转移病例,同时被诊断为慢性淋巴细胞白血病(CLL)。案例演示。56岁女性,有常规输血史,因胆囊炎引起慢性疲劳和反复右上腹部疼痛。此外,双乳均可触及结节,随后超声检查为可疑钙化灶。发现白细胞增多和双细胞减少。行胆囊切除术及部分组织活检。胆囊和脐区皮下组织显示提示乳腺癌的肿瘤细胞。骨髓活检显示CLL和非造血细胞与先前检测到的肿瘤细胞相同。免疫组化显示乳腺癌为er阳性、pr阳性、her2阴性。结果。经过彻底的调查,骨髓抑制被证明是由于乳腺癌的转移性骨髓病变,同时诊断为慢性淋巴细胞白血病。结论。这种情况迫使临床医生对以细胞减少为表现的肿瘤患者的诊断方法和治疗更加体贴。这是为了避免诊断不足,并确保每一个病理在骨髓调查和相应的管理。
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引用次数: 0
Burns of the head and neck – from physiological to psychological impact 头颈部烧伤——从生理到心理的影响
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.5
M. Tiglis, Ș. Popescu, T. Neagu, I. Lascar
Burn injuries have a long-term negative impact on patients, families, and healthcare systems, and prevention remains the primary goal. Head and neck lesions have a reported prevalence between 6-65.6%, sometimes even 95.1%. There are various risk factors and predictors of facial burns, like younger age, male sex, flame or flash burns, and work-related injuries. Surgical and non-surgical management is chosen depending on the burn type and extension, and the patients’ previous health status. Tangential necrosectomy is the gold standard of third-degree burn care. In the last years, enzymatic debridement showed promising results. Long-term complications, from altered sensibility, and face motor dysfunction, to hypertrophic scarring and mutilating aspects, frequently lead to depression, post-traumatic stress disorders, and social exclusion. To improve patients’ quality of life, various programs targeting reconstructive surgeries with cosmetic purposes, social skill training, and cognitive behavioural therapies should be implemented.
烧伤对患者、家庭和医疗保健系统都有长期的负面影响,预防仍然是首要目标。据报道,头颈部病变的患病率为6-65.6%,有时甚至为95.1%。面部烧伤有多种危险因素和预测因素,如年龄小、男性、火焰或闪光烧伤以及与工作有关的伤害。根据烧伤的类型和范围,以及患者以往的健康状况,选择手术和非手术治疗。切向坏死切除术是三度烧伤护理的黄金标准。在过去的几年里,酶清创显示出令人鼓舞的结果。长期并发症,从敏感性改变和面部运动功能障碍,到肥厚性疤痕和致残方面,经常导致抑郁症、创伤后应激障碍和社会排斥。为了提高患者的生活质量,应实施以美容为目的的重建手术、社交技能训练和认知行为治疗为目标的各种项目。
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引用次数: 0
The significance of preoperative thrombocytosis in ovarian cancer patients 卵巢癌患者术前血小板增多的意义
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.7
I. Bălescu, Nicoale Bacalbasa, I. Brezean, C. Stoica, C. Tomescu, Cristina Martac, Andrei Voichitoiu, B. Gaspar
The presence of an increased number of platelets has been demonstrated to be significantly associated with the presence of different types of malignancies, especially when it comes to gynecological cancers and seems to be associated with a poorer prognosis. This fact has been widely studied in order to better understand the physiopathology of the phenomenon, the impact on the overall outcomes and to validate new therapeutic lines for such cases. The aim of the current paper is to review the most important studies conducted on this issue.
血小板数量的增加已被证明与不同类型恶性肿瘤的存在显著相关,特别是当涉及到妇科癌症时,似乎与较差的预后有关。这一事实已被广泛研究,以便更好地了解该现象的生理病理,对总体结果的影响,并验证此类病例的新治疗方法。本文的目的是回顾在这个问题上进行的最重要的研究。
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引用次数: 0
Transient neonatal myasthenia gravis: case report 新生儿短暂性重症肌无力1例
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.3
Diana Iulia Vasilescu, A. Dan, Vlad Dima, M. Cirstoiu
Transient neonatal myasthenia gravis (TNMG) is a distinct type of myasthenia gravis (MG), a temporary autoimmune condition due to the mother’s antibodies crossing over the placenta and affecting the baby. Studies suggest that 10 to 15% of infants born to mothers suffering from MG will develop TNMG. Undoubtedly, if not diagnosed and treated in time, TNMG can be a serious condition, even life-threatening. Almost 80% of newborns will present symptoms in the first 24 hours of life that will last up to 4 weeks and a complete recovery is expected by 2 months of age. Only 10% of the affected infants may still be symptomatic at 4 months.
新生儿短暂性重症肌无力(TNMG)是一种不同类型的重症肌无力(MG),是由于母亲的抗体越过胎盘而影响婴儿的一种暂时性自身免疫性疾病。研究表明,患有MG的母亲所生的婴儿中有10%至15%会患上TNMG。毫无疑问,如果不及时诊断和治疗,TNMG可能会成为严重的疾病,甚至危及生命。几乎80%的新生儿将在出生后24小时内出现症状,这种症状将持续4周,预计到2个月大时将完全康复。只有10%的受影响婴儿在4个月时仍有症状。
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引用次数: 0
Bromelain-based enzymatic debridement in hand burns – an easier way to manage a difficult patient: case report 以菠萝蛋白酶为基础的手烧伤酶清创——一种处理难治性病人的简便方法:病例报告
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.4
T. Neagu, Eliza Bordeanu-Diaconescu, M. Tiglis, I. Peride, I. Lascar
Introduction. Bromelain-based enzymatic debridement may be considered the standard in patients with upper extremity burns management, regarding the low risk of bleeding, wound infections, reduction of surgical timing, and the decreased risk of compartment syndrome development. Case presentation. We present the case of hand and face burns in a patient presenting deep venous thrombosis of the lower limb extended to the level of the vena cava, and bilateral pulmonary embolism. The enzymatic debridement reduced periprocedural bleeding and allowed a faster recovery and therefore the resumption of oral anticoagulation and antiplatelet medication in a patient with important cardiac, arterial, and renal comorbidities. Conclusion. Bromelain-based enzymatic debridement use is recommended in patients presenting upper limb deep burns, especially in anatomically challenging areas, like hand fingers, and especially in those with a previous medical history that predisposes them to periprocedural bleeding and increased risk of poor healing.
介绍。基于菠萝蛋白酶的酶清创可以被认为是上肢烧伤患者治疗的标准方法,因为出血、伤口感染的风险低,减少了手术时间,降低了筋膜室综合征发生的风险。案例演示。我们提出的情况下,手和脸烧伤的病人呈现下肢深静脉血栓形成延伸到腔静脉的水平,和双侧肺栓塞。酶清创减少术中出血,使恢复更快,因此对有重要心脏、动脉和肾脏合并症的患者恢复口服抗凝和抗血小板药物治疗。结论。建议对上肢深度烧伤的患者使用菠萝蛋白酶酶清创,特别是在解剖上具有挑战性的部位,如手指,特别是那些既往病史易导致术中出血和愈合不良风险增加的患者。
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引用次数: 0
Sleep apnea in patients with primary chronic headache 原发性慢性头痛患者的睡眠呼吸暂停
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.8
Alirio Rodrigo Bastidas Goyes, Sayuris Henríquez Ortiz, Edward J. Acero Mondragon, Estefanía Collazos Bahamon, B. Mantilla, Eduardo Tuta Quintero, G.A. Hincapie Diaz, Elías Quintero Muñoz, David Acosta Hernández, Camila Martínez Ayala
Introduction. Sleep apnea syndrome (SAS) can accompany patients with chronic primary headache (CPH), being a frequent cause of persistence of symptoms in these patients, however, the data studying this disorder in patients with CPH are still limited. Objective. To determine the frequency of SAS in patients with CPH. Methods. A retrospective cohort was analyzed in patients with a diagnosis of CPH in a third level hospital. CPH was diagnosed according to the criteria of the International Headache Society and SAS with a polysomnographic record with an apnea-hypopnea index (AHI) >5/h, the frequency of SAS was determined among the total number of patients with AHI >5/h over the total number of patients undergoing polysomnography. Results. A total of 114 subjects were included, where the SAS in CPH was 83.3%, of which 56.8% were men and 60% older than 50 years; 89% of the population had a body mass index (BMI) greater than 27 kg/m2. Fatigue and sleepiness during the day were the most frequent symptoms, reported in 89.5% of the population with SAS compared to 47.4% of the population without a diagnosis of SAS. Conclusion. Sleep apnea is a frequent condition in patients with CPH undergoing polysomnography, mainly overweight men over 50 years of age. The main associated symptoms are fatigue and sleepiness.
介绍。睡眠呼吸暂停综合征(SAS)可伴随慢性原发性头痛(CPH)患者,是慢性原发性头痛患者症状持续的常见原因,然而,研究该疾病在CPH患者中的数据仍然有限。目标。目的:测定CPH患者发生SAS的频率。方法。对某三甲医院诊断为CPH的患者进行回顾性队列分析。CPH的诊断依据国际头痛学会和SAS的标准,并有多导睡眠图记录,呼吸暂停低通气指数(AHI) >5/h,以AHI >5/h的患者总数除以接受多导睡眠图检查的患者总数来确定SAS的发生频率。结果。共纳入114名受试者,其中CPH的SAS为83.3%,其中男性56.8%,年龄大于50岁的占60%;89%的人口体重指数(BMI)大于27 kg/m2。白天疲劳和困倦是最常见的症状,在89.5%的SAS患者中报告,而在未诊断为SAS的人群中,这一比例为47.4%。结论。睡眠呼吸暂停是接受多导睡眠检查的CPH患者的常见病,主要是50岁以上的超重男性。主要的相关症状是疲劳和困倦。
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引用次数: 0
Phenotypic characteristics and clinical outcome in hospitalized patients with COVID-19 and diabetes 新冠肺炎合并糖尿病住院患者的表型特征及临床转归
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.6
K. Poposki, M. Bosilkovski, K. Grozdanovski, Z. Sopova, Arlinda Osmani, D. Jakimovski, D. Georgievska, T. Milenković
Objectives. The aim is to describe the phenotypic, biological and clinical characteristics of hospitalized patients with COVID-19 and diabetes, and the association with the clinical outcome of the patients. Material and methods. This single-center, retrospective study was conducted on 200 patients. The primary endpoint was death observed within day 7, 14 and beyond day 14 of hospitalization, and secondary objective was to compare the survival group with non-survival group. The variables that demonstrated significant association with primary endpoint were subject to multivariate binary logistic regression analysis. Outcomes. The estimated prevalence was 17.87% of the total COVID-19 hospitalizations during this period (n=1119). The majority of the patients were with diabetes mellitus type 2 with a median age of 67 years and BMI of 27.8 kg/m2. On admission, 156 patients (78%) presented with severe/critical illness. A total of 93 patients (46.5%) met the primary endpoint, with most deaths occurring within day 7 of hospital stay. Non-survival group showed significantly higher levels of leucocytes count, more pronounced lymphopenia, higher CRP, LDH and D-dimer levels. Multivariate analysis identified four independent risk factors associated with death: age OR 1.05 (CI 95% 1.01-1.09), severity of disease at admission OR 0.22 (CI 95, 0.07-0.65), COVID-19 vaccination status OR 3.07 (CI 95%, 1.36-6.91) and LDH levels OR 1.00 (CI 95%,1.002-1.008). Conclusions. Diabetic patients admitted to hospital for COVID-19 infection tend to have high mortality rate. Severity of disease at admission, advanced age, not completed vaccination and increased LDH levels are independent risk factors for lethal outcome, irrespective of diabetes status.
目标。目的是描述COVID-19合并糖尿病住院患者的表型、生物学和临床特征,以及与患者临床转归的关系。材料和方法。本研究为单中心回顾性研究,共纳入200例患者。主要终点是住院第7天、第14天和第14天以后观察到的死亡,次要目的是比较生存组和非生存组。对与主要终点有显著相关性的变量进行多元二元logistic回归分析。结果。在此期间,估计患病率占COVID-19住院总人数的17.87% (n=1119)。患者以2型糖尿病为主,中位年龄67岁,BMI为27.8 kg/m2。入院时,156名患者(78%)出现严重/危重疾病。共有93名患者(46.5%)达到了主要终点,大多数死亡发生在住院第7天内。未存活组白细胞计数明显升高,淋巴细胞减少更明显,CRP、LDH和d -二聚体水平升高。多因素分析确定了4个与死亡相关的独立危险因素:年龄OR 1.05 (CI 95% 1.01-1.09)、入院时疾病严重程度OR 0.22 (CI 95, 0.07-0.65)、COVID-19疫苗接种状况OR 3.07 (CI 95%, 1.36-6.91)和LDH水平OR 1.00 (CI 95%,1.002-1.008)。结论。因COVID-19感染住院的糖尿病患者死亡率高。入院时疾病严重程度、高龄、未完成疫苗接种和LDH水平升高是致死性结局的独立危险因素,与糖尿病状态无关。
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引用次数: 0
The role of spinal ultrasound in the diagnosis of spinal dysraphism – correlation with MRI examination 脊柱超声在脊柱畸形诊断中的作用——与MRI检查的相关性
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.1
A. Toma, M. Iriciuc, Vlad Dima, R. Bohîlțea, A. Bivoleanu
The paper presents the clinical, ultrasound and MRI appearances in the case of the closed spinal dysraphisms with a cutaneous/ subcutaneous mass: lypomyelomeningocele, posterior meningocele and cervical meningocele. There is mentioned first the classification of these defects, then, for each type, a case example is presented, showing the clinical aspect of the lesion, the ultrasound features and the correlation of ultrasound with MRI images. The examples show a good correlation between ultrasound and MRI, entitling the ultrasound exam to be the first line of exploration in the case of this category of patients.
本文介绍了闭合性脊柱发育异常伴皮肤/皮下肿块的临床、超声和MRI表现:脊髓脊膜脊膜膨出、后脑膜膨出和颈脑膜膨出。首先提到这些缺陷的分类,然后,针对每种类型,给出一个案例,显示病变的临床方面,超声特征以及超声与MRI图像的相关性。这些例子显示了超声和MRI之间良好的相关性,使超声检查成为这类患者的第一道探索线。
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引用次数: 0
Managing intrauterine growth restriction 处理宫内生长限制
Pub Date : 2022-12-31 DOI: 10.37897/rmj.2022.4.2
M. Plotogea, C. Mehedințu, V. Varlas, Francesca Frîncu, R. Mateescu, A. Edu, Vlad Dima, C. Andreescu, A. Petca, Denisa-Andreea Dorneanu
The fetal growth normally depends on sufficient delivery of oxygen and nutrients mainly via the placenta. Inadequate fetal nutrition may result in poor development and adaptation that permanently alter the fetus' metabolism and physiology. Intrauterine Growth Restriction is defined as a deviation on the fetal growth pattern. An estimated fetal weight (EFW) that is below the 10th percentile for gestational age is commonly used to describe fetal growth restriction. Usually obtained sonographically, there is evidence that ultrasound imaging of the uterine artery, middle cerebral artery, and fetal umbilical artery during the late third-trimester (approximately 35-37 weeks) significantly improves the detection and diagnosis of IUGR. In obstetrics, an increased risk of perinatal mortality and morbidity is associated with the diagnosis of IUGR.
胎儿的生长正常依赖于主要通过胎盘提供足够的氧气和营养。胎儿营养不足可能导致发育不良和适应不良,从而永久性地改变胎儿的代谢和生理。宫内生长受限被定义为胎儿生长模式的偏离。估计胎儿体重(EFW)低于胎龄的第10个百分位数通常用于描述胎儿生长受限。有证据表明,妊娠晚期(约35-37周)子宫动脉、大脑中动脉和胎儿脐动脉的超声成像可显著提高IUGR的发现和诊断。在产科,围产期死亡和发病风险的增加与IUGR的诊断有关。
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引用次数: 0
期刊
Romanian Medical Journal
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