I. Bălescu, Nicoale Bacalbasa, I. Brezean, C. Stoica, C. Tomescu, Cristina Martac, Andrei Voichitoiu, B. Gaspar
In the last decades understanding the relationship between the circulating platelets and the biological aggressivity of ovarian cancer gave the opportunity to researchers to introduce new therapeutic lines in ovarian cancer patients with promising results. Therefore, this subject has become intensively studied and surprising correlation ships have been observed. One of the most recently investigated issues regards the influence of circulating platelets on epithelial ovarian cancer refers to the platelets’ ability to induce the epithelial to mesenchymal transition. The current paper aims to discuss about this subject and about the clinical implications of the process.
{"title":"Understanding the relationship between circulating platelets and epithelial to mesenchymal transition – a step towards in discovering new epithelial ovarian cancer targeted therapies","authors":"I. Bălescu, Nicoale Bacalbasa, I. Brezean, C. Stoica, C. Tomescu, Cristina Martac, Andrei Voichitoiu, B. Gaspar","doi":"10.37897/rmj.2022.3.8","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.8","url":null,"abstract":"In the last decades understanding the relationship between the circulating platelets and the biological aggressivity of ovarian cancer gave the opportunity to researchers to introduce new therapeutic lines in ovarian cancer patients with promising results. Therefore, this subject has become intensively studied and surprising correlation ships have been observed. One of the most recently investigated issues regards the influence of circulating platelets on epithelial ovarian cancer refers to the platelets’ ability to induce the epithelial to mesenchymal transition. The current paper aims to discuss about this subject and about the clinical implications of the process.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73694747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Starting from the end of the XIXth century, a decrease in infant mortality was observed worldwide. Care of preterm infants became the domain of dedicated units inside hospitals and technology became more complex. Neonatal Intensive Care Units were created throughout the world, increasing infant survival chances regardless of age and pathology. Alongside Neonatology, better means of investigating the pregnancies were discovered. Ultrasound use during pregnancy improved the chances of identifying complex genetic syndromes, some incompatible with survival after birth. It is considered that Stéphane Tarnier (1828–1897) is the architect of Perinatology, many of his inventions had a major role in the evolution of Obstetrics and Neonatology (the Tarnier forceps, the basiotribe, intrauterine balloon for inducing the labor, gavage feeding of the preemies). But only in 1967 the term “perinatology” was mentioned for the first time in a German paper. Professor Emeritus Erich Saling is the father or perinatology. He introduced the evaluation of gas exchange for the fetus during labor and the examination of amniotic fluid during the last weeks of pregnancy. Today, Perinatology is a widely used concept, but the road to creating this concept was long and needed the work of many prominent doctors.
{"title":"Perinatology – the link between Obstetrics and Neonatology","authors":"Vlad Dima","doi":"10.37897/rmj.2022.3.7","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.7","url":null,"abstract":"Starting from the end of the XIXth century, a decrease in infant mortality was observed worldwide. Care of preterm infants became the domain of dedicated units inside hospitals and technology became more complex. Neonatal Intensive Care Units were created throughout the world, increasing infant survival chances regardless of age and pathology. Alongside Neonatology, better means of investigating the pregnancies were discovered. Ultrasound use during pregnancy improved the chances of identifying complex genetic syndromes, some incompatible with survival after birth. It is considered that Stéphane Tarnier (1828–1897) is the architect of Perinatology, many of his inventions had a major role in the evolution of Obstetrics and Neonatology (the Tarnier forceps, the basiotribe, intrauterine balloon for inducing the labor, gavage feeding of the preemies). But only in 1967 the term “perinatology” was mentioned for the first time in a German paper. Professor Emeritus Erich Saling is the father or perinatology. He introduced the evaluation of gas exchange for the fetus during labor and the examination of amniotic fluid during the last weeks of pregnancy. Today, Perinatology is a widely used concept, but the road to creating this concept was long and needed the work of many prominent doctors.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78793373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudia Andreea Palcau, Ș. Busnatu, Livia Florentina Paduraru, Alexandru Cosmin Palcău, O. Andronic, N. Paun, A. Stănescu
Psoriasis is a chronic, systemic inflammatory disease that has gained popularity among scientific research from many promising perspectives on diagnosis and treatment. Individuals with psoriasis associate numerous comorbidities and have many predisposing factors in common especially with heart disease. Based on this, researchers tried to identify the common pathogenic mechanisms, the impact of risk factors on both pathologies, the influence of one disease on the another as well as the impact of novel therapies used in psoriasis on cardiovascular system, in order to improve the prognosis and quality of life of these patients. Areas of uncertainty. Pathogenic mechanisms involved both in psoriasis and atherosclerotic disease are not fully understood, especially in relationship with actual treatment strategies and their impact on prognosis. The purpose of this descriptive review is to summarize the latest available data, to see whether current treatment strategies of psoriatic disease should take into consideration the risk of cardiovascular disease (CVD) when one drug should be chosen at the expense of another. Data sources. Literature research was performed using electronic database (PubMed, Cochrane Library and Web of Science) between January 2010 and June 2022. We used different keywords and MeSH terms to generate the most relevant results regarding psoriasis and cardiovascular disease. First, we evaluated the titles and abstracts of the articles and we excluded papers that didn’t met selection criteria.
银屑病是一种慢性全身性炎症性疾病，在科学研究中从许多有希望的诊断和治疗方面得到了广泛的关注。牛皮癣患者有许多合并症，有许多共同的诱发因素，特别是心脏病。在此基础上，研究人员试图确定银屑病的共同致病机制、危险因素对两种病理的影响、一种疾病对另一种疾病的影响以及银屑病新疗法对心血管系统的影响，以改善患者的预后和生活质量。不确定的领域。银屑病和动脉粥样硬化疾病的发病机制尚不完全清楚，特别是与实际治疗策略的关系及其对预后的影响。这篇描述性综述的目的是总结最新的可用数据，看看当前银屑病的治疗策略在选择一种药物时是否应该考虑到心血管疾病(CVD)的风险。数据源。文献研究于2010年1月至2022年6月期间使用PubMed、Cochrane Library和Web of Science等电子数据库进行。我们使用不同的关键词和MeSH术语来生成关于牛皮癣和心血管疾病的最相关的结果。首先，我们评估了文章的标题和摘要，排除了不符合选择标准的论文。
{"title":"Reducing cardiovascular burden in psoriasis patients by using specific therapies – How close are we?","authors":"Claudia Andreea Palcau, Ș. Busnatu, Livia Florentina Paduraru, Alexandru Cosmin Palcău, O. Andronic, N. Paun, A. Stănescu","doi":"10.37897/rmj.2022.3.1","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.1","url":null,"abstract":"Psoriasis is a chronic, systemic inflammatory disease that has gained popularity among scientific research from many promising perspectives on diagnosis and treatment. Individuals with psoriasis associate numerous comorbidities and have many predisposing factors in common especially with heart disease. Based on this, researchers tried to identify the common pathogenic mechanisms, the impact of risk factors on both pathologies, the influence of one disease on the another as well as the impact of novel therapies used in psoriasis on cardiovascular system, in order to improve the prognosis and quality of life of these patients. Areas of uncertainty. Pathogenic mechanisms involved both in psoriasis and atherosclerotic disease are not fully understood, especially in relationship with actual treatment strategies and their impact on prognosis. The purpose of this descriptive review is to summarize the latest available data, to see whether current treatment strategies of psoriatic disease should take into consideration the risk of cardiovascular disease (CVD) when one drug should be chosen at the expense of another. Data sources. Literature research was performed using electronic database (PubMed, Cochrane Library and Web of Science) between January 2010 and June 2022. We used different keywords and MeSH terms to generate the most relevant results regarding psoriasis and cardiovascular disease. First, we evaluated the titles and abstracts of the articles and we excluded papers that didn’t met selection criteria.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74550154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Toma, B. Gont, A. Nemeș, Vlad Dima, R. Bohîlțea, A. Bivoleanu
The incomplete ossification of the spinal processes allows the ultrasonographic evaluation of the spinal cord and the adjacent structures in neonates and small infants. The paper describes the ultrasonographic examination of the spinal structures and the normal appearance of the spinal cord, the structures within the spinal canal, and the bony and muscular adjacent structures. Sagittal and axial sections at cervical, thoracic, lumbar, and sacral levels are described. There are also mentioned findings in the M mode and Doppler examinations.
{"title":"Spinal ultrasound – Identification of the normal structures","authors":"A. Toma, B. Gont, A. Nemeș, Vlad Dima, R. Bohîlțea, A. Bivoleanu","doi":"10.37897/rmj.2022.3.3","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.3","url":null,"abstract":"The incomplete ossification of the spinal processes allows the ultrasonographic evaluation of the spinal cord and the adjacent structures in neonates and small infants. The paper describes the ultrasonographic examination of the spinal structures and the normal appearance of the spinal cord, the structures within the spinal canal, and the bony and muscular adjacent structures. Sagittal and axial sections at cervical, thoracic, lumbar, and sacral levels are described. There are also mentioned findings in the M mode and Doppler examinations.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"67 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76388622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Cărămidă, M. Dumitrache, M. Ionica, R. Sfeatcu, A. Stănescu, L. Tribuș
Objectives. The aim of this study was the assessment of the exposure to fluoride through oral homecare products as well as professional applications for a group of children from Bucharest, Romania. Materials and methods. The cross-sectional study was conducted in 2021 on a sample of 207 subjects from Bucharest, Romania, including parents with children between 1 and 12 years distributed in three age groups: 1-2 years, 3-5 years and 6-12 years. The assessment used a 10 items questionnaire, on-line and self-administered and completed by the parents most involved in child’s oral health. Results. The correct concentration of fluoride in child’s toothpaste was used as it follows 3.7% of 1-2 year-olds, 4.24% of 3-5 year-olds, 8.06% 6-12 year-olds. The age-adapted recommended quantity of toothpaste was used for 37.4% of children of 1-2 years, 61.86% of children of 3-5 years and 24.19% of children of 6-12 years. Twice-daily tooth brushing was performed by 40.74% 1-2 year-olds, 44.92% 3-5 year-olds, 62.90% 6-12 year-olds. In-office professional fluoridation was low, 88.89% of 1-2 years old children, 92.37% of 3-5 years old children and 77.42% 6-12 years old children were never exposed to such preventive procedures. Conclusions. Children from the present study had a suboptimal exposure to fluoride through oral home care products as well as to topical in-office professionally application of high concentration fluoride products.
{"title":"Exposure to fluoride through daily oral home-care and professionally procedures in the dental office for a group of Romanian children","authors":"Mariana Cărămidă, M. Dumitrache, M. Ionica, R. Sfeatcu, A. Stănescu, L. Tribuș","doi":"10.37897/rmj.2022.3.4","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.4","url":null,"abstract":"Objectives. The aim of this study was the assessment of the exposure to fluoride through oral homecare products as well as professional applications for a group of children from Bucharest, Romania. Materials and methods. The cross-sectional study was conducted in 2021 on a sample of 207 subjects from Bucharest, Romania, including parents with children between 1 and 12 years distributed in three age groups: 1-2 years, 3-5 years and 6-12 years. The assessment used a 10 items questionnaire, on-line and self-administered and completed by the parents most involved in child’s oral health. Results. The correct concentration of fluoride in child’s toothpaste was used as it follows 3.7% of 1-2 year-olds, 4.24% of 3-5 year-olds, 8.06% 6-12 year-olds. The age-adapted recommended quantity of toothpaste was used for 37.4% of children of 1-2 years, 61.86% of children of 3-5 years and 24.19% of children of 6-12 years. Twice-daily tooth brushing was performed by 40.74% 1-2 year-olds, 44.92% 3-5 year-olds, 62.90% 6-12 year-olds. In-office professional fluoridation was low, 88.89% of 1-2 years old children, 92.37% of 3-5 years old children and 77.42% 6-12 years old children were never exposed to such preventive procedures. Conclusions. Children from the present study had a suboptimal exposure to fluoride through oral home care products as well as to topical in-office professionally application of high concentration fluoride products.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84094612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective. The aim of the study was to determine effectiveness of radiofrequency denervation of facet joints in combination with periarticular administration of local anaesthetics and steroids for elimination of pain in patients with low lumbar pain and predominantly spondyloarthritis. Material and methods. 78 patients with lower lumbar pain syndrome and arcuate joints arthrosis as a leading clinical manifestation underwent radiofrequency denervation of facet joints and periarticular administration of local anaesthetic and steroid drug (main group). The control group involved 136 patients with lumbar pain and dominating spondylarthritis treated only by radiofrequency denervation of facet joints. Results. Both in the early and late periods after treatment, reliable results were obtained in treatment of chronic lower lumbar pain caused mainly by arcuate joints damage both in the main and control groups. However, there was a significant difference between the main group and the control group in the early period (in three months after treatment), in favour of the main group. In the late period (in 1 year after treatment) a reliable treatment result was obtained both in the main and control groups, but there was no difference in the treatment results between these groups. Conclusions. Periarticular administration of local anaesthetics and steroids is effective in the short term, and radiofrequency denervation of facet joints is effective in both the short and longer term.
{"title":"Treatment of spondyloarthritis (facet syndrome) by puncture techniques","authors":"MV Kvasnitskyi","doi":"10.37897/rmj.2022.3.5","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.5","url":null,"abstract":"Objective. The aim of the study was to determine effectiveness of radiofrequency denervation of facet joints in combination with periarticular administration of local anaesthetics and steroids for elimination of pain in patients with low lumbar pain and predominantly spondyloarthritis. Material and methods. 78 patients with lower lumbar pain syndrome and arcuate joints arthrosis as a leading clinical manifestation underwent radiofrequency denervation of facet joints and periarticular administration of local anaesthetic and steroid drug (main group). The control group involved 136 patients with lumbar pain and dominating spondylarthritis treated only by radiofrequency denervation of facet joints. Results. Both in the early and late periods after treatment, reliable results were obtained in treatment of chronic lower lumbar pain caused mainly by arcuate joints damage both in the main and control groups. However, there was a significant difference between the main group and the control group in the early period (in three months after treatment), in favour of the main group. In the late period (in 1 year after treatment) a reliable treatment result was obtained both in the main and control groups, but there was no difference in the treatment results between these groups. Conclusions. Periarticular administration of local anaesthetics and steroids is effective in the short term, and radiofrequency denervation of facet joints is effective in both the short and longer term.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85595664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Carpal tunnel syndrome is currently the most common peripheral nerve compression neuropathy that affects approximately 1% of the population. The incidence of CTS seems to be increasing. The diagnosis is based on clinical symptoms and electrodiagnostic studies. The purpose of this study is to analyze the effects of the endoscopic technique on patients with carpal tunnel syndrome. In addition, we want to demonstrate if this condition occurs more in men than in women. Methods. In a group of 53 patients we used the endoscopic technique for the treatment of carpal syndrome, and as a measure of its effectiveness we used the Phalen, Durken and Tinel tests. Also, for the qualitative analysis of the data, the clinical and demographic characteristics of the patients were taken into account. Results. We identified statistically significant differences between men and women regarding the occurrence of carpal syndrome, women having significantly lower results than men in the Phalen, Durken and Tinel tests (X2Phalen(2) =17.33, X2Durken(2) =15.94, X2Tinel(2) =10.76, p<0.05). There are statistically significant differences between the results of the Phalen, Durken and Tinel tests before and after surgery (WPhalen=111.24, WDurken=139.91, WTinel=102.46, p<0.05).
{"title":"Endoscopic treatment in carpal tunnel syndrome: a case study in Bucharest – Romania","authors":"Hazim Elayan, A. Oproiu, R. Jecan, I. Florescu","doi":"10.37897/rmj.2022.3.6","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.6","url":null,"abstract":"Background. Carpal tunnel syndrome is currently the most common peripheral nerve compression neuropathy that affects approximately 1% of the population. The incidence of CTS seems to be increasing. The diagnosis is based on clinical symptoms and electrodiagnostic studies. The purpose of this study is to analyze the effects of the endoscopic technique on patients with carpal tunnel syndrome. In addition, we want to demonstrate if this condition occurs more in men than in women. Methods. In a group of 53 patients we used the endoscopic technique for the treatment of carpal syndrome, and as a measure of its effectiveness we used the Phalen, Durken and Tinel tests. Also, for the qualitative analysis of the data, the clinical and demographic characteristics of the patients were taken into account. Results. We identified statistically significant differences between men and women regarding the occurrence of carpal syndrome, women having significantly lower results than men in the Phalen, Durken and Tinel tests (X2Phalen(2) =17.33, X2Durken(2) =15.94, X2Tinel(2) =10.76, p<0.05). There are statistically significant differences between the results of the Phalen, Durken and Tinel tests before and after surgery (WPhalen=111.24, WDurken=139.91, WTinel=102.46, p<0.05).","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82486664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Plotogea, C. Mehedințu, V. Varlas, C. Berceanu, R. Mateescu, A. Edu, Vlad Dima, C. Andreescu, A. Petca, G. Ionescu
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder which affects brain, spinal cord and optic nerve. During last years the perception over the disease changed dramatically, now being considered a handleable disease. The particularity of this subject is that Multiple Sclerosis is a disease which affects mostly young women, many of them not having any children at the moment of diagnosis. This article highlights the fact that women diagnosed with Multiple Sclerosis are allowed to get pregnant, and, moreover, they are encouraged to live a normal life. In most cases, disease activity freezes during pregnancy, only a small percentage of women will continue to have clinically and radiologically active disease. For those women, IFN-β and Glatiramer Acetate are the first-choice therapies that should be given. In cases when the disease is not responding to common medication, refractory to treatment forms may be successfully treated with Natalizuab, during the first and the second trimester. Breastfeeding is also encouraged, as it has a protective effect on disease progression. The main purpose of this article is to make a literature review in which to summarize the updates regarding pregnancy and postpartum management, relapses management and, also, the impact of pregnancy on Multiple Sclerosis course. The analysis was limited to articles written in English and published between August 2019 - October 2022 on PubMed, NCBI and Medical Journals.
{"title":"Pregnancy in the context of Multiple Sclerosis","authors":"M. Plotogea, C. Mehedințu, V. Varlas, C. Berceanu, R. Mateescu, A. Edu, Vlad Dima, C. Andreescu, A. Petca, G. Ionescu","doi":"10.37897/rmj.2022.3.2","DOIUrl":"https://doi.org/10.37897/rmj.2022.3.2","url":null,"abstract":"Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder which affects brain, spinal cord and optic nerve. During last years the perception over the disease changed dramatically, now being considered a handleable disease. The particularity of this subject is that Multiple Sclerosis is a disease which affects mostly young women, many of them not having any children at the moment of diagnosis. This article highlights the fact that women diagnosed with Multiple Sclerosis are allowed to get pregnant, and, moreover, they are encouraged to live a normal life. In most cases, disease activity freezes during pregnancy, only a small percentage of women will continue to have clinically and radiologically active disease. For those women, IFN-β and Glatiramer Acetate are the first-choice therapies that should be given. In cases when the disease is not responding to common medication, refractory to treatment forms may be successfully treated with Natalizuab, during the first and the second trimester. Breastfeeding is also encouraged, as it has a protective effect on disease progression. The main purpose of this article is to make a literature review in which to summarize the updates regarding pregnancy and postpartum management, relapses management and, also, the impact of pregnancy on Multiple Sclerosis course. The analysis was limited to articles written in English and published between August 2019 - October 2022 on PubMed, NCBI and Medical Journals.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective. To identify differences and similarities in trends and patterns of cardiovascular mortality in Central (Romania and Poland) and Eastern (Moldova and Ukraine) European countries before and after the political transition. Material and methods. The mortality series reconstructed according to ICD-10 since 1970 for Moldova, Ukraine and Poland and since 1980 for Romania were used. Directly standardized death rates by sex, age and detailed cardiovascular disease were computed. Results. After a long period of stagnation or rise, cardiovascular mortality started declining after 1991 in Poland, 1995 in Moldova, 1997 in Romania and 2005 in Ukraine. The progress in Romania and Poland was associated with both heart diseases and cerebrovascular diseases. In Moldova and Ukraine, the recent improvements were primarily related to cerebrovascular diseases. Compared to Central Europe, the quality of codification of heart diseases was found poor in Eastern Europe. Conclusions. The lack of effective control of mortality from heart diseases is the major public health problem in Moldova and in pre-war Ukraine. Romania and Poland follow very similar mortality patterns and trends, though with a certain time lag.
{"title":"Cardiovascular mortality in Central and Eastern Europe: differences and similarities","authors":"Olga Penina","doi":"10.37897/rmj.2022.2.2","DOIUrl":"https://doi.org/10.37897/rmj.2022.2.2","url":null,"abstract":"Objective. To identify differences and similarities in trends and patterns of cardiovascular mortality in Central (Romania and Poland) and Eastern (Moldova and Ukraine) European countries before and after the political transition. Material and methods. The mortality series reconstructed according to ICD-10 since 1970 for Moldova, Ukraine and Poland and since 1980 for Romania were used. Directly standardized death rates by sex, age and detailed cardiovascular disease were computed. Results. After a long period of stagnation or rise, cardiovascular mortality started declining after 1991 in Poland, 1995 in Moldova, 1997 in Romania and 2005 in Ukraine. The progress in Romania and Poland was associated with both heart diseases and cerebrovascular diseases. In Moldova and Ukraine, the recent improvements were primarily related to cerebrovascular diseases. Compared to Central Europe, the quality of codification of heart diseases was found poor in Eastern Europe. Conclusions. The lack of effective control of mortality from heart diseases is the major public health problem in Moldova and in pre-war Ukraine. Romania and Poland follow very similar mortality patterns and trends, though with a certain time lag.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86690260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Peşu, E. C. Zărnescu, N. Zarnescu, N. Sanda, Stejara Nicoleta Mihai, A. Salageanu, Ş. Neagu
Although most recurrences (approximately 80%) occur in the first three years after a curative resection, a recurrence of CRC can occur even ten years after the initial curative resection (dormant spread of cancer cells). Immunotherapy is an emerging therapy with high potential. The immune system plays a major role in the development of CRC. This has led to innovative new therapies, such as cancer vaccines and T-cell stimulation therapies. Cantastim belongs to the class of nonspecific immunostimulators or immunomodulators, most of which are of bacterial origin and are used as mono- or polymicrobial suspensions. Cantastim is an ethanolic extract obtained from a pathogenic strain of Pseudomonas aeruginosa serotype XV. The beneficial effect of immunotherapy with Cantastim was more pronounced for the local developmental stages (I and II) than for the later stages.
{"title":"Impact of immunotherapy with pseudomonas serotip xv etanolic extract (Cantastim) on local recurrence and survival at 3 and 5 years in operated rectal cancer","authors":"D. Peşu, E. C. Zărnescu, N. Zarnescu, N. Sanda, Stejara Nicoleta Mihai, A. Salageanu, Ş. Neagu","doi":"10.37897/rmj.2022.2.4","DOIUrl":"https://doi.org/10.37897/rmj.2022.2.4","url":null,"abstract":"Although most recurrences (approximately 80%) occur in the first three years after a curative resection, a recurrence of CRC can occur even ten years after the initial curative resection (dormant spread of cancer cells). Immunotherapy is an emerging therapy with high potential. The immune system plays a major role in the development of CRC. This has led to innovative new therapies, such as cancer vaccines and T-cell stimulation therapies. Cantastim belongs to the class of nonspecific immunostimulators or immunomodulators, most of which are of bacterial origin and are used as mono- or polymicrobial suspensions. Cantastim is an ethanolic extract obtained from a pathogenic strain of Pseudomonas aeruginosa serotype XV. The beneficial effect of immunotherapy with Cantastim was more pronounced for the local developmental stages (I and II) than for the later stages.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83364414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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