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A Comparative Study on the Effect of Omega-3 Fatty Acids on Lactation Omega-3脂肪酸对泌乳影响的比较研究
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-22 DOI: 10.1002/mnfr.70393
İrem Mutlu Durğut, Hayrunnisa Yeşil Sarsmaz, Seren Gülşen Gürgen

This study aimed to investigate the effects of maternal supplementation with fish oil, flaxseed oil, and walnut oil rich in omega-3 fatty acids during lactation on mammary tissue structure and milk quality. Rats were randomly assigned to negative control, control, fish oil, walnut oil, and flaxseed oil groups. The supplements were administered by oral gavage from parturition (Day 0) to the end of lactation (Day 21). Mammary tissues were evaluated immunohistochemically, and blood samples were analyzed biochemically. The docosahexaenoic acid (DHA) level in the fish oil group was significantly higher than in other groups (p < 0.05). Fatty Acid Desaturase-2 (FADS2) levels also differed significantly between the negative control and all other groups (p < 0.05), while no significant change was observed in the walnut oil group (p > 0.05). Immunostaining intensities for insulin-like growth factor 1 (IGF-1), transforming growth factor beta 1 (TGF-β1), and vascular endothelial growth factor (VEGF) varied significantly among all groups (p < 0.05). These findings suggest that maternal fish oil supplementation during lactation more effectively enhances milk quality and mammary tissue function than flaxseed or walnut oil, indicating its potential as a dietary strategy to improve milk composition and support offspring nutrition.

Trial Registration: Registered on the Clinical Trial Registry (www.clinicaltrials.gov; Clinical Trials identifier: NCT06111378 (26/10/2023)

本研究旨在探讨哺乳期母体补充富含omega-3脂肪酸的鱼油、亚麻籽油和核桃油对乳腺组织结构和乳质的影响。将大鼠随机分为阴性对照组、对照组、鱼油组、核桃油组和亚麻籽油组。从分娩(第0天)到哺乳结束(第21天),通过灌胃给予这些补充剂。对乳腺组织进行免疫组织化学评价,并对血液样本进行生化分析。鱼油组二十二碳六烯酸(DHA)水平显著高于其他各组(p < 0.05)。脂肪酸去饱和酶-2 (FADS2)水平在阴性对照组和其他各组之间也有显著差异(p < 0.05),而核桃油组无显著变化(p < 0.05)。各组间胰岛素样生长因子1 (IGF-1)、转化生长因子β1 (TGF-β1)、血管内皮生长因子(VEGF)免疫染色强度差异有统计学意义(p < 0.05)。这些研究结果表明,在哺乳期补充鱼油比亚麻籽油或核桃油更有效地提高了乳质和乳腺组织功能,表明鱼油有可能作为改善乳成分和支持后代营养的饮食策略。
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引用次数: 0
Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR-29a-5p/P53 Signaling in the Tumor Microenvironment 靶向衰老:天麻颗粒通过调节肿瘤微环境中miR-29a-5p/P53信号抑制结直肠癌进展
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-22 DOI: 10.1002/mnfr.70338
Xiaojuan Tang, Yuan Ren, Yongmin Li, Yuan Lv, Liang Zhao, Yongheng He

Chemotherapy-induced senescence-associated tumor microenvironment (S-TME) facilitates colorectal cancer (CRC) progression. This study elucidates the mechanism by which Tianma granule (TMG), a traditional Chinese medicine formula, remodels the S-TME and inhibits CRC, specifically investigating the role of the miR-29a-5p/P53 axis. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) identified 18 bioactive components in TMG, and network pharmacology highlighted P53 as a core target. Functional assays, including Cell Counting Kit-8 (CCK-8), β-galactosidase staining, flow cytometry, wound-healing, and Transwell migration tests, were conducted using doxorubicin (DOX)–induced senescent human umbilical vein endothelial cells (HUVECs) and CRC lines. TMG suppressed CRC cell proliferation, motility, and invasiveness while promoting apoptosis. TMG reduced P53/cyclin-dependent kinase inhibitor 1A (P21) and senescence-associated secretory phenotype (SASP) factors (IL-6, IL-8, CCL20), while upregulating miR-29a-5p in senescent HUVECs. miR-29a-5p inhibition enhanced senescence and increased P53/P21/SASP, whereas P53 silencing lowered P21 and decreased miR-29a-5p, indicating mutual regulation. In azoxymethane/dextran sulfate sodium (AOM/DSS)-CRC mice, TMG reduced tumor burden and improved survival, accompanied by lower P53/P21 and restored miR-29a-5p in tissues. TMG remodels the chemotherapy-induced S-TME and suppresses CRC progression by modulating the miR-29a-5p/P53 axis, enhancing apoptosis in senescent cells, and counteracting S-TME-mediated tumor growth and metastasis. This highlights TMG's therapeutic potential.

化疗诱导的衰老相关肿瘤微环境(S-TME)促进结直肠癌(CRC)的进展。本研究阐明了中药复方天麻颗粒(TMG)重塑S-TME并抑制CRC的机制,具体探讨了miR-29a-5p/P53轴的作用。液相色谱-串联质谱(LC-MS /MS)鉴定出TMG中18种生物活性成分,网络药理学强调P53为核心靶点。使用阿霉素(DOX)诱导的衰老人脐静脉内皮细胞(HUVECs)和结直肠癌细胞系进行功能检测,包括细胞计数试剂盒-8 (CCK-8)、β-半乳糖苷酶染色、流式细胞术、伤口愈合和Transwell迁移试验。TMG抑制结直肠癌细胞增殖、运动和侵袭性,同时促进细胞凋亡。TMG降低了P53/细胞周期蛋白依赖性激酶抑制剂1A (P21)和衰老相关分泌表型(SASP)因子(IL-6、IL-8、CCL20),同时上调了衰老huvec中miR-29a-5p。抑制miR-29a-5p促进衰老,增加P53/P21/SASP,而P53沉默降低P21,降低miR-29a-5p,表明相互调节。在偶氮甲烷/葡聚糖硫酸钠(AOM/DSS)-CRC小鼠中,TMG降低肿瘤负荷,提高生存率,同时降低P53/P21水平,恢复组织中miR-29a-5p水平。TMG通过调节miR-29a-5p/P53轴,增强衰老细胞凋亡,抑制S-TME介导的肿瘤生长和转移,重塑化疗诱导的S-TME,抑制CRC进展。这凸显了TMG的治疗潜力。
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引用次数: 0
Discovery of the Underlying Mechanism of Ginger Juice Processed Ziziphi Spinosae Semen for Its Sedative-Hypnotic Effect on Insomnia Mice via Regulation of HPA Axis and cAMP/PKA Signaling Pathway 通过调节HPA轴和cAMP/PKA信号通路发现姜汁处理的酸枣子对失眠小鼠镇静催眠作用的潜在机制
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-21 DOI: 10.1002/mnfr.70327
Lintong Xie, Xia Zhang, Fangfang Xue, Yifei Gao, Jizhen Guo, Hui Zhu, Xiao Liu

Based on Traditional Chinese Medicine (TCM) theory, the efficacy and mechanism of Ginger juice processed Ziziphi Spinosae Semen (GJPZSS) for treating insomnia, particularly stress-related types, were investigated to provide empirical evidence. An insomnia model was induced in mice by DL-4-chlorophenylalanine (PCPA) and chronic tail clamping. The sedative effect was evaluated by behavioral tests. Serum components from GJPZSS were analyzed by UHPLC-Q-TOF-MS/MS, and 64 potential targets were identified. The cAMP signaling pathway was enriched as the core pathway by Kyoto Encyclopedia of genes and genomes (KEGG) analysis and was validated by molecular docking. GJPZSS was demonstrated to prolong sleep time, reduce immobility time, increase 5-hydroxytryptamine (5-HT) and gamma-aminobutyric acid (GABA) levels, decrease hypothalamic-pituitary-adrenal (HPA) axis levels, and suppress neuronal death. The reduction of the cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the brain was also significantly inhibited. It was concluded that the sleep-improving effect of GJPZSS was mediated through the regulation of the HPA axis and the cAMP/PKA/CREB/BDNF signaling pathway.

本文以中医理论为基础,研究生姜汁处理的酸枣子(GJPZSS)治疗失眠,特别是应激相关性失眠的疗效和机制,为其提供经验证据。采用dl -4-氯苯丙氨酸(PCPA)和慢性夹尾诱导小鼠失眠模型。通过行为试验评价镇静效果。采用UHPLC-Q-TOF-MS/MS对GJPZSS血清成分进行分析,鉴定出64个潜在靶点。通过京都基因与基因组百科全书(KEGG)分析,cAMP信号通路被富集为核心通路,并通过分子对接得到验证。GJPZSS可延长睡眠时间,减少静止时间,增加5-羟色胺(5-HT)和γ -氨基丁酸(GABA)水平,降低下丘脑-垂体-肾上腺(HPA)轴水平,抑制神经元死亡。脑内环磷酸腺苷(cAMP)、蛋白激酶A (PKA)、cAMP反应元件结合蛋白(CREB)和脑源性神经营养因子(BDNF)的减少也被显著抑制。综上所述,GJPZSS的睡眠改善作用是通过调节HPA轴和cAMP/PKA/CREB/BDNF信号通路介导的。
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引用次数: 0
The Effects of Biofortified Cowpeas on Iron, Glucose, and Lipid Metabolism in Rats Fed a High-Fat/High-Sugar Diet 生物强化豇豆对高脂/高糖饮食大鼠铁、葡萄糖和脂质代谢的影响
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-21 DOI: 10.1002/mnfr.70392
Ana Paula Ribeiro Gaspar, Cíntia Tomaz Sant' Ana, Mariana Grancieri, Ana Paula Carvalho de Moura Cruz, Leone Soromenho Viana, Eduardo Lorencetti Fornazier, Marisa da Silva Corrêa, Henrique Jordem Venial, Jankerle Neves Boeloni, Neuza Maria Brunoro Costa

Iron deficiency anemia may affect carbohydrates and lipid metabolism. This study aimed to evaluate the iron bioavailability from biofortified cowpeas in the context of a high-fat/high-sugar diet and its relationship with carbohydrate and lipid metabolism. Forty-eight Wistar rats were induced to anemia for 21 days, and during the repletion phase (35 days), the animals received diets containing 12 ppm of iron from ferrous sulfate or biofortified (BRS Aracê and BRS Tumucumaque) and a conventional (BRS Pajeú) cowpeas. The biofortified cowpea Aracê showed a hemoglobin gain similar to ferrous sulfate, improved crypt size in the colon, lowered insulin levels and area under the curve in the glucose tolerance test compared to ferrous sulfate (p < 0.05). Hepcidin levels were similar between the groups. The biofortified cowpeas increased the production of short-chain fatty acids compared to ferrous sulfate (p < 0.05). Both biofortified and conventional cowpeas increased HDL-c concentrations, reduced the total cholesterol/HDL-c ratio, and decreased fecal triglyceride excretion (p < 0.05). The biofortification process favors beneficial metabolic changes in the iron, glucose, and lipid metabolism.

缺铁性贫血可能影响碳水化合物和脂质代谢。本研究旨在评估高脂/高糖饮食背景下生物强化豇豆铁的生物利用度及其与碳水化合物和脂质代谢的关系。48只Wistar大鼠被诱导贫血21天,在饱食期(35天),这些动物被喂食含有12 ppm硫酸亚铁或生物强化铁(BRS Aracê和BRS Tumucumaque)和传统豇豆(BRS Pajeú)的饲料。与硫酸亚铁相比,生物强化豇豆Aracê的血红蛋白增加与硫酸亚铁相似,结肠隐窝大小增加,胰岛素水平降低,葡萄糖耐量试验曲线下面积降低(p < 0.05)。两组间Hepcidin水平相似。与硫酸亚铁相比,生物强化豇豆提高了短链脂肪酸的产量(p < 0.05)。生物强化豇豆和常规豇豆均能提高HDL-c浓度,降低总胆固醇/HDL-c比值,减少粪便甘油三酯排泄(p < 0.05)。生物强化过程有利于铁、葡萄糖和脂质代谢的有益代谢变化。
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引用次数: 0
Gut Microbiota Composition in Adolescents From Mexico City, Associations With Nutritional and Socioeconomic Factors: Results From a Pilot Study 墨西哥城青少年肠道菌群组成与营养和社会经济因素的关系:一项初步研究的结果
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-21 DOI: 10.1002/mnfr.70386
Armando Navarro, Gerardo E. Rodea, Aldo Hugo de la Cruz-Montoya, Clara Estela Díaz-Velásquez, Felipe Vaca-Paniagua, Armando Navarro-Cid del Prado, Laura L. Tirado-Gómez, Ariel Vilchis-Reyes, Guadalupe García de la Torre, Verónica Cruz-Licea, Carlos Eslava-Campos, Hugo G. Castelán-Sánchez

The gut microbiota is a key determinant of metabolic health in adolescence, a critical period for the onset of obesity. Understanding its associations with body mass index (BMI), diet, and socioeconomic status (SES) helps identify early determinants of metabolic risk. We analyzed stool samples from 95 Mexican adolescents (11–15 years) using 16S rRNA V3–V4 sequencing. The main phyla were Bacteroidetes, Firmicutes, and Proteobacteria, with. At the genus level Azobacteroides Candidatus, Parabacteroides, Bacteroides, and Prevotella being the most abundant. Overweight and obese adolescents showed lower diversity and more Bacteroidetes, while normal-weight peers had more Firmicutes and beneficial taxa. Lactobacillus was enriched in normal-weight individuals, while Parabacteroides and Prevotella were more abundant in adolescents with low SES. A diet high in sugar-sweetened beverages and low in whole grains was associated with a predominance of Bacteroides and lower diversity. Low SES was also associated with potential pathogens, including Escherichia and Salmonella, and gastrointestinal symptoms. In particular, Vibrio and Salmonella were inversely associated with cholesterol and triglycerides, while Clostridiodes was positively correlated with triglycerides. Diet and SES influenced the adolescent gut microbiome, by shaping diversity, potentially pathogenic taxa, and their associations with metabolic health indicators.

肠道微生物群是青春期代谢健康的关键决定因素,而青春期是肥胖症发病的关键时期。了解其与身体质量指数(BMI)、饮食和社会经济地位(SES)的关系有助于确定代谢风险的早期决定因素。我们使用16S rRNA V3-V4测序分析了95名墨西哥青少年(11-15岁)的粪便样本。主要门为拟杆菌门、厚壁菌门和变形菌门。在属水平上,拟Azobacteroides Candidatus, Parabacteroides, Bacteroides和Prevotella是最丰富的。超重和肥胖的青少年显示出较低的多样性和更多的拟杆菌门,而正常体重的同龄人有更多的厚壁菌门和有益的分类群。乳酸菌在正常体重人群中富集,而副杆菌和普雷沃氏菌在社会经济地位低的青少年中富集。高含糖饮料和低全谷物的饮食与拟杆菌的优势和较低的多样性有关。低SES还与潜在病原体(包括埃希氏菌和沙门氏菌)和胃肠道症状有关。特别是弧菌和沙门氏菌与胆固醇和甘油三酯呈负相关,而梭菌与甘油三酯呈正相关。饮食和SES通过塑造多样性、潜在致病性分类群及其与代谢健康指标的关联,影响了青少年肠道微生物群。
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引用次数: 0
Docosahexaenoic Acid Consumption Early in Life Improves Immune Dysfunction in High-Fat Diet-Fed Wistar Rats in a Sex-Specific Manner 生命早期摄入二十二碳六烯酸以性别特异性方式改善高脂肪饮食喂养的Wistar大鼠的免疫功能障碍。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-21 DOI: 10.1002/mnfr.70391
Ren Wang, Susan Goruk, Catherine B. Chan, Catherine J. Field

To investigate whether early-life docosahexaenoic acid (DHA) consumption mitigated the effects of a high-fat diet (HFD) on body composition, endocrine hormones, immune function, inflammatory biomarkers, and identify sex differences.

Wistar rats were fed (PND 0–70) diets differing only in fat composition: control low-fat (10% fat, 0% arachidonic acid [ARA], 0% DHA), control high-fat (HF, 20% fat, 0% ARA, 0% DHA), or DHA HF (20% fat, 1% ARA, 2% DHA) (n = 16/group, males/females = 8/8). Plasma hormones (ELISA), inflammatory biomarkers (electrochemiluminescence), splenocytes phenotype (immunofluorescence), and ex vivo cytokine production (ELISA) after mitogen stimulation were measured. HFD did not alter body weight/composition or inflammatory profile but increased plasma glucagon-like peptide 1 (GLP-1, males, p = 0.02). In the spleen, HFD lowered transforming growth factor-beta (TGF-β) and increased interleukin (IL)-10 (females) and IL-2 production (p < 0.03). It also lowered % of regulatory T cells (Treg), B cells (males), conventional type 1dendritic cells (cDC1), and MHC-II and CD86 expression (males) (p < 0.03). DHA mitigated HFD-related changes in plasma GLP-1 (males) andTGF-β, IL-10 (females), and IL-2 production (p ≤ 0.03) and increased % of B cells (males), cDC1, MHC-II, and CD86 expression (males) (p < 0.03).

DHA mitigated HFD-induced impaired Treg response and compromised adaptive immunity and antigen-presenting function in a sex-specific manner.

研究早期摄入二十二碳六烯酸(DHA)是否会减轻高脂肪饮食(HFD)对身体成分、内分泌激素、免疫功能、炎症生物标志物的影响,并确定性别差异。Wistar大鼠饲喂(PND 0 ~ 70)仅脂肪组成不同的饲粮:对照低脂(10%脂肪、0%花生四烯酸[ARA]、0% DHA)、对照高脂(HF、20%脂肪、0% ARA、0% DHA)或DHA HF(20%脂肪、1% ARA、2% DHA) (n = 16/组,公/母= 8/8)。测定丝裂原刺激后的血浆激素(ELISA)、炎症生物标志物(电化学发光)、脾细胞表型(免疫荧光)和体外细胞因子产生(ELISA)。HFD没有改变体重/组成或炎症特征,但增加了血浆胰高血糖素样肽1 (GLP-1,男性,p = 0.02)。在脾脏中,HFD降低了转化生长因子-β (TGF-β),增加了白细胞介素(IL)-10(雌性)和IL-2的产生(p
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引用次数: 0
The Effect of Dietary Fiber Compositions on the Therapeutic Outcome of Combined Radio- and Immunotherapy in a Preclinical Cancer Model 膳食纤维成分对临床前癌症模型放射和免疫联合治疗结果的影响
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-20 DOI: 10.1002/mnfr.70370
Annemarie J. F. Westheim, Ludwig J. Dubois, Elia Prades-Sagarra, Jiyang Chan, Alexander M. A. van der Wiel, Natasja G. Lieuwes, Rianne Biemans, Ying Cong, Tom Houben, Dennis M. Meesters, Ala Yaromina, Miriam van Dijk, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, John Penders, Ronit Shiri-Sverdlov, Jan Theys

Several studies demonstrated curative responses of combined radio-immunotherapy, although not standard-of-care for most cancers. Increased fiber intake has been associated with improved radiotherapy and immunotherapy outcomes, but fiber compositions’ impact remains unclear. This study aimed to explore whether dietary fiber composition influences the therapeutic outcome of combined radio-immunotherapy in a preclinical cancer model. A syngeneic mouse model of colon cancer (CT26) (female BALB/cOla Hsd) was used. Mice were randomized into three groups (n = 12) of iso-caloric diets with different fiber compositions. Five instances of local radiotherapy on tumors, combined with injections of anti-PD-L1, were administered over 5 and 10 days. Diets’ impact was assessed on progression-free survival, SCFA levels in fecal and cecal samples, gut microbiome composition, and immunological profile. Progression-free survival was different between compositions, as well as their gut microbiota community structure, at all measured time-points. Therapeutic outcome (cure) was negatively associated with the relative abundance of Bacteroides and positively with Atopobiaceae Family. There was no association with SCFA levels. Cured mice displayed smaller spleens containing increased proportions of CD8+ T-cells and decreased proportions of myeloid-derived suppressor cells. Our data suggest that fiber composition may influence therapeutic outcome of combined radio-immunotherapy treatment in vivo.

几项研究证明了放射免疫联合治疗的疗效,尽管它不是大多数癌症的标准治疗方法。纤维摄入量的增加与放疗和免疫治疗效果的改善有关,但纤维成分的影响尚不清楚。本研究旨在探讨膳食纤维成分是否会影响临床前癌症模型放射免疫联合治疗的疗效。采用同基因结肠癌小鼠(CT26)(雌性BALB/cOla Hsd)模型。将小鼠随机分为三组(n = 12),分别饲喂不同纤维成分的等热量膳食。5例肿瘤局部放疗联合注射抗pd - l1,疗程分别为5天和10天。研究评估了饮食对无进展生存期、粪便和盲肠样本中SCFA水平、肠道微生物组组成和免疫学特征的影响。在所有测量的时间点,不同的组合物以及他们的肠道微生物群群落结构之间的无进展生存是不同的。治疗结果(治愈)与拟杆菌科的相对丰度呈负相关,与托氏杆菌科呈正相关。与SCFA水平无关。治愈小鼠脾脏变小,CD8+ t细胞比例增加,髓源性抑制细胞比例减少。我们的数据表明纤维成分可能会影响体内放射-免疫联合治疗的治疗结果。
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引用次数: 0
Pyridoxal 5′-Phosphate Suppresses Growth of Pancreatic Adenocarcinoma Cells In Vitro via Regulation of Oncogenic RAS 吡哆醛5′-磷酸通过调控致癌RAS抑制胰腺腺癌细胞的生长
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-20 DOI: 10.1002/mnfr.70333
Jack Feehan, Barry Kitchen, Sarah Fraser, Nicholas Tripodi, Narges Dargahi, Vasso Apostolopoulos

Pancreatic cancer treatment typically involves surgery, chemotherapy, and radiotherapy. However, recent studies are investigating alternative therapeutic strategies, including targeted therapies, immunotherapy, and the adjunctive use of compounds like vitamin B6. PLP functions as a cofactor in over 100 enzymatic reactions crucial for amino acid metabolism, neurotransmitter production, and heme synthesis. Previous studies demonstrated PLP's anti-cancer properties in human lymphoma cells, demonstrating its anti-proliferative and anti-migratory effects, as well as its influence on cytokine levels and checkpoint marker expression. Herein, we further investigated PLP's anti-cancer effects on human pancreatic cancer cells, showing a reduction in cell growth, disruption of the mitochondrial membranes, increased superoxide production, and the induction of apoptosis. In addition, PLP treatment in BxPC3 cells affects transcripts related to key pathways like E2F, G2M Checkpoint, mTOR, and KRAS, enhancing functional protein networks that may improve anti-cancer effects. In PANC1 cells, PLP reduces KRAS-related transcripts and increases those involved in Tumor Necrosis Factor signaling and the unfolded protein response, suggesting a regulatory role that may enhance cellular stress responses. Overall, the findings from this study indicate that PLP may pave the way for more effective therapeutic adjunctive options in the management of pancreatic cancer.

胰腺癌的治疗通常包括手术、化疗和放疗。然而,最近的研究正在研究替代治疗策略,包括靶向治疗、免疫治疗和维生素B6等化合物的辅助使用。PLP在100多种酶促反应中发挥辅助因子的作用,这些酶促反应对氨基酸代谢、神经递质产生和血红素合成至关重要。既往研究证实PLP在人淋巴瘤细胞中具有抗癌特性,具有抗增殖和抗迁移作用,以及对细胞因子水平和检查点标志物表达的影响。在此,我们进一步研究了PLP对人类胰腺癌细胞的抗癌作用,显示了细胞生长减少,线粒体膜破坏,超氧化物产生增加,诱导细胞凋亡。此外,PLP在BxPC3细胞中的治疗影响了与E2F、G2M检查点、mTOR和KRAS等关键通路相关的转录本,增强了可能提高抗癌作用的功能性蛋白网络。在PANC1细胞中,PLP减少kras相关转录本,增加参与肿瘤坏死因子信号和未折叠蛋白反应的转录本,表明其调节作用可能增强细胞应激反应。总的来说,本研究的结果表明,PLP可能为胰腺癌管理中更有效的治疗辅助选择铺平道路。
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引用次数: 0
Issue Information: Mol. Nutr. Food Res. 2'26 发布信息:Mol. Nutr。Food Res. 2'26
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-20 DOI: 10.1002/mnfr.70396
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引用次数: 0
Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health—A Narrative Review 婴儿肠道编程:母亲和早期生命营养如何塑造婴儿微生物群和长期健康-叙述性综述。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-19 DOI: 10.1002/mnfr.70385
Fanette Fontaine, Sondra Turjeman, Meriam Haib, Maria Carmen Collado, Karel Callens, Omry Koren

Childhood malnutrition, including undernutrition, obesity, and micronutrient deficiencies, remains a major global health burden. Emerging evidence points to the gut microbiome as a critical mediator linking maternal, prenatal, and early-life nutrition to long-term offspring health outcomes. From conception and through the first years of life, maternal diet, metabolic state, and environmental exposures shape offspring microbial colonization and maturation. Breastfeeding and consumption of fiber-rich and fermented foods (maternal and post-weaning) support beneficial microbiota, while high-fat, high-sugar diets, xenobiotics, and artificial additives may promote dysbiosis. The composition and diversity of the infant microbiome influence immune, metabolic, and neurodevelopmental processes and may also contribute to the intergenerational transmission of malnutrition. While commercial formulas increasingly include “biotics” to mimic human milk, exclusive breastfeeding remains the gold standard. Complementary feeding practices, including timing and diet quality, are known to modulate microbial maturation. Diet-based interventions in pregnancy show promise in improving microbiome function and preventing disease in offspring. Because the microbiome is highly plastic in the first years of life, this window offers unique opportunities for preventive strategies targeting maternal and child nutrition. Integrating microbiome science into public health and dietary guidelines could enhance current approaches to breaking the cycle of malnutrition and promoting lifelong health.

儿童营养不良,包括营养不足、肥胖和微量营养素缺乏,仍然是全球主要的健康负担。新出现的证据表明,肠道微生物群是将母体、产前和早期营养与后代长期健康结果联系起来的关键中介。从受孕到生命的最初几年,母亲的饮食、代谢状态和环境暴露都会影响后代微生物的定植和成熟。母乳喂养和食用富含纤维和发酵的食物(产妇和断奶后)支持有益微生物群,而高脂肪、高糖饮食、异种抗生素和人工添加剂可能会促进生态失调。婴儿微生物组的组成和多样性影响免疫、代谢和神经发育过程,也可能导致营养不良的代际传递。虽然商业配方奶越来越多地加入模仿母乳的“生物”,但纯母乳喂养仍然是黄金标准。已知辅食做法,包括时间和饮食质量,可以调节微生物的成熟。以饮食为基础的妊娠干预在改善微生物组功能和预防后代疾病方面显示出希望。由于微生物组在生命的最初几年具有高度可塑性,这一窗口期为针对孕产妇和儿童营养的预防战略提供了独特的机会。将微生物组科学纳入公共卫生和饮食指南可以加强目前打破营养不良循环和促进终身健康的方法。
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Molecular Nutrition & Food Research
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