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Oxidative Balance Score, Genetic Predictors of the Gut Microbiome, and the Risk of Metabolic-Associated Fatty Liver Disease: A Cohort Study 氧化平衡评分、肠道微生物组的遗传预测因子和代谢性脂肪性肝病的风险:一项队列研究
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70372
Xiang Ji, Yawen Wang, Liuxin Li, Honghao Yang, Zheng Ma, Chenying Wang, Yuhong Zhao, Yang Ding, Yang Xia

The oxidative balance score (OBS) integrates dietary and lifestyle factors to reflect oxidative stress. OBS has been associated with metabolic dysfunction–associated steatotic liver disease (MASLD), but the modifying roles of genetic predisposition and gut microbiota remain unclear. This study evaluated the prospective association between OBS and MASLD and potential modification by genetic and microbial factors. We analyzed 182 601 UK Biobank participants free of MASLD at baseline. OBS was calculated from 16 dietary and 4 lifestyle components. Incident MASLD cases were identified from hospital and death records. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). During a median 10.5 years of follow-up, 1500 participants developed MASLD. Compared with the lowest OBS quartile, adjusted HRs (95% CIs) were 0.82 (0.71–0.94), 0.71 (0.61–0.83), and 0.68 (0.58–0.81) for the second, third, and fourth quartiles (p-trend < 0.001). MASLD genetic risk score (GRS) and microbial GRSs for Ruminococcus torques and Sutterella were associated with MASLD risk but did not modify the OBS–MASLD association (all p-interaction > 0.05). Higher OBS was associated with lower MASLD risk, independent of genetic and microbial GRSs. These findings provide prospective association evidence that may inform future intervention studies.

氧化平衡评分(OBS)综合饮食和生活方式因素来反映氧化应激。OBS与代谢功能障碍相关的脂肪变性肝病(MASLD)有关,但遗传易感性和肠道微生物群的调节作用尚不清楚。本研究评估了OBS和MASLD之间的潜在关联以及遗传和微生物因素对其进行修饰的可能性。我们分析了182 601名在基线时没有MASLD的UK Biobank参与者。OBS由16种饮食和4种生活方式组成。从医院和死亡记录中确定突发MASLD病例。Cox比例风险模型估计了风险比(hr)和95%置信区间(ci)。在平均10.5年的随访期间,1500名参与者发展为MASLD。与最低的OBS四分位数相比,第二、第三和第四四分位数的校正hr (95% ci)分别为0.82(0.71-0.94)、0.71(0.61-0.83)和0.68 (0.58-0.81)(p趋势0.05)。较高的OBS与较低的MASLD风险相关,与遗传和微生物GRSs无关。这些发现提供了前瞻性关联证据,可能为未来的干预研究提供信息。
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引用次数: 0
Association of Fish Consumption, Dietary Omega-3 Polyunsaturated Fatty Acids With Phenotypic Age Acceleration in Adults After Considering Blood Cadmium Levels 考虑血镉水平后,鱼类消费、膳食Omega-3多不饱和脂肪酸与成人表型年龄加速的关系
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70364
Xiaoya Sun, Jingyi Ren, Zhenao Zhang, Huanting Pei, Chongyue Zhang, Ziyi Wang, Siqi Zhu, Rui Wen, Xiaolong Zhang, Yuxia Ma

Fish is rich in nutrients; however, concerns persist regarding its potential role in delaying aging due to the possible accumulation of cadmium. This study aimed to assess the association between fish consumption, dietary ω-3 polyunsaturated fatty acids (PUFAs), and Phenotypic Age Acceleration (PhenoAgeAccel) in the presence of cadmium exposure. The study used data from National Health and Nutrition Examination Survey (NHANES) 2011-2018. Multiple linear regression, restricted cubic splines (RCS), and subgroup analysis were used to assess potential associations. Mediation analysis further examined whether blood cadmium levels mediated the association between fish consumption and PhenoAgeAccel. Results showed that higher fish consumption and ω-3 PUFAs intake were significantly associated with lower PhenoAgeAccel. This association persisted even in the presence of cadmium exposure. Furthermore, the association between fish consumption or ω-3 PUFAs and PhenoAgeAccel was more pronounced in people with low cadmium exposure levels. RCS analysis revealed a non-linear relationship between fish consumption and dietary ω-3 PUFAs and PhenoAgeAccel. Blood cadmium levels partially mediated the association between fish consumption and PhenoAgeAccel. Our results support dietary recommendations to consume fish to slow biological aging. Even in the presence of cadmium exposure, fish consumption was negatively associated with PhenoAgeAccel.

鱼营养丰富;然而,由于镉的可能积累,人们一直担心它在延缓衰老方面的潜在作用。本研究旨在评估镉暴露下鱼类摄取量、膳食ω-3多不饱和脂肪酸(PUFAs)和表型年龄加速(PhenoAgeAccel)之间的关系。该研究使用了2011-2018年国家健康与营养检查调查(NHANES)的数据。使用多元线性回归、受限三次样条(RCS)和亚组分析来评估潜在的关联。中介分析进一步研究了血镉水平是否介导了鱼类消费与PhenoAgeAccel之间的关联。结果表明,较高的鱼类摄取量和ω-3 PUFAs摄取量与较低的PhenoAgeAccel显著相关。即使在镉暴露的情况下,这种关联仍然存在。此外,食用鱼类或ω-3 PUFAs与PhenoAgeAccel之间的关联在镉暴露水平较低的人群中更为明显。RCS分析显示,鱼类食用量与膳食ω-3 PUFAs和PhenoAgeAccel呈非线性关系。血镉水平部分介导了鱼类消费与表型加速之间的关系。我们的研究结果支持食用鱼类以减缓生物衰老的饮食建议。即使在存在镉暴露的情况下,鱼类消费与表型加速呈负相关。
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引用次数: 0
Two′-Fucosyllactose, a Human Milk Oligosaccharide, Promotes Intestinal Remodeling and Enhances Nutrient and Functional Component Absorption 2 '-聚焦乳糖,一种人乳低聚糖,促进肠道重塑,提高营养和功能成分的吸收。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70376
Sho Nishikawa, Hidetoshi Yamada, Yuto Funasaki, Wakana Jike, Mai Taromaru, Satomi Ozaki, Izuki Tarushima, Ryoto Tanaka, Sayuki Nishimaki, Miyu Sato, Hanami Goto, Masaya Kato, Masayoshi Okuzawa, Raimu Miyasaka

2-Fucosyllactose (2′FL) is an abundant human milk oligosaccharide and is recognized for its diverse biological benefits. The aim of this study was to investigate the effects of 2′FL supplementation on small intestinal remodeling and the associated enhancement of nutrient absorption capabilities. Mice were orally supplemented with 2′FL daily for 20 d. This supplementation significantly increased the length of the small intestine and the density of villi, with no adverse effects on intestinal barrier function. Mice treated with 2′FL exhibited an enhanced absorption of triglycerides containing docosahexaenoic acid in lipid tolerance tests. Additionally, the absorption of CL316,243 and curcumin was significantly increased in the co-administration groups. This was accompanied by elevated uncoupling protein 1 levels in inguinal adipose tissue. Our study showed that 2′FL enhances nutrient and functional compound absorption by promoting intestinal remodeling. This highlights the novel role of 2′FL—a non-nutritive compound—in supporting intestinal health. Our findings suggest potential applications of 2′FL in growth promotion, lifestyle-related disease prevention, and frailty reduction, thereby advancing research on the nutritional functions of food-derived compounds.

2'-焦酰基乳糖(2' fl)是一种丰富的人乳低聚糖,因其多种生物学益处而被公认。本研究的目的是研究补充2'FL对小肠重塑和营养吸收能力的影响。小鼠每天口服2'FL,持续20 d。这种补充显著增加了小肠长度和绒毛密度,对肠道屏障功能无不良影响。在脂质耐量试验中,用2'FL处理的小鼠对含有二十二碳六烯酸的甘油三酯的吸收增强。此外,共给药组对CL316,243和姜黄素的吸收显著增加。这伴随着腹股沟脂肪组织中解偶联蛋白1水平的升高。我们的研究表明,2'FL通过促进肠道重塑来促进营养和功能性化合物的吸收。这突出了2' fl -一种非营养性化合物-支持肠道健康的新作用。我们的发现提示了2'FL在促进生长、预防生活方式相关疾病和减少虚弱方面的潜在应用,从而推动了对食物衍生化合物营养功能的研究。
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引用次数: 0
Gramineae Wheat Germ Extract Ameliorates Methylglyoxal-Induced Neurobehavioral Deficits Through Modulation of the Gut Microbiota and Tryptophan Metabolism 小麦胚芽提取物通过调节肠道微生物群和色氨酸代谢改善甲基乙二醛诱导的神经行为缺陷。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70383
Po-Lin Tsai, Yao-Tsung Yeh, Tsui-Jung Yu, Yu-Kuo Chen, Chorng-An Liao, Min-Hsi Chiu, Hui-Yun Tsai

Emerging evidence highlights the pivotal role of the gut–brain axis (GBA) in the pathogenesis of neurodegenerative diseases, with gut microbiota and tryptophan-derived metabolites acting as key modulators. In this study, we investigated the neuroprotective potential of wheat germ extract (WGE) in a methylglyoxal (MG)-induced neurodegenerative mouse model. Male C57BL/6J mice were randomly assigned into four groups: Control (C), Methylglyoxal (MG, 1% MG in drinking water), GABA (1% MG + 200 mg/kg/day GABA), or WGE (1% MG + 200 mg/kg/day WGE). WGE significantly improved spatial learning, alleviated anxiety-like behaviors, and reduced hippocampal damage and Tau hyperphosphorylation. Moreover, WGE reshaped gut microbiota composition by decreasing the abundance of pathogenic taxa, including Helicobacter hepaticus, Eubacterium plexicaudatum, Lachnospiraceae bacterium TWA4 sp000875945, Ventrisoma, and Oribacterium, while restoring the levels of the beneficial TANB77 bacterium CAG-793 sp000433915. WGE also replenished neuroprotective tryptophan metabolites, particularly indole-3-propionic acid (IPA) and indole-3-lactic acid (ILA), and modulated host functional pathways related to cell motility and epithelial signaling associated with Helicobacter pylori infection. These findings demonstrate that WGE may exert neuroprotective effects by modulating gut microbiota composition and tryptophan metabolism, providing novel insights into GBA-targeted strategies for the prevention of neurodegenerative disorders.

新出现的证据强调了肠脑轴(GBA)在神经退行性疾病发病机制中的关键作用,肠道微生物群和色氨酸衍生代谢物起着关键的调节作用。在这项研究中,我们研究了小麦胚芽提取物(WGE)在甲基乙二醛(MG)诱导的神经退行性小鼠模型中的神经保护作用。雄性C57BL/6J小鼠随机分为4组:对照组(C)、甲基乙二醛(MG,饮用水中1% MG)、GABA (1% MG + 200 MG /kg/day GABA)、WGE (1% MG + 200 MG /kg/day WGE)。WGE显著改善了空间学习,减轻了焦虑样行为,减轻了海马损伤和Tau过度磷酸化。此外,WGE重塑了肠道微生物群的组成,降低了致病分类群的丰度,包括肝幽门螺杆菌、丛状真杆菌、毛螺杆菌科细菌TWA4 sp000875945、Ventrisoma和Oribacterium,同时恢复了有益细菌TANB77 CAG-793 sp000433915的水平。WGE还补充了神经保护性色氨酸代谢物,特别是吲哚-3-丙酸(IPA)和吲哚-3-乳酸(ILA),并调节了与幽门螺杆菌感染相关的细胞运动和上皮信号传导相关的宿主功能途径。这些发现表明,WGE可能通过调节肠道微生物群组成和色氨酸代谢来发挥神经保护作用,为以gba为目标的预防神经退行性疾病的策略提供了新的见解。
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引用次数: 0
Dietary Flavonoid, Gut Microbiota, and Intestinal Diseases: A Review With Bibliometric Trends and Research Insights 膳食类黄酮、肠道微生物群和肠道疾病:文献计量学趋势和研究见解综述。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70368
Mohd Tauseef Khan, Sneha Mohanty, Sunita Devi, Sapna Sharma, Prabhanshu Tripathi

Flavonoids are one of the bioactive compounds among polyphenols that are found in fruits and vegetables. The flavonoids mostly get metabolized in the alimentary canal, and their interaction with the gut microbiome becomes inevitable. The gut microbiota continuously interacts with dietary flavonoids and catabolizes them into more minor metabolites directly associated with the host health. The gut microbiota is resilient and highly dependent on environmental entities, such as xenobiotics, antibiotics, and diet patterns. Any abrupt alterations in these exogenous entities cause gut dysbiosis, resulting in different abnormalities and disorders. The flavonoids alter the proportion of Firmicutes to Bacteroidetes in the gut, and those bacteria play a decisive role in the host physiology. This review draws attention to how flavonoids ameliorate gut dysbiosis and inflammation. Additionally, the biomarkers and cell signaling before and after the onset of gut dysbiosis have been discussed. Ultimately, we emphasize how flavonoid-mediated gut microbiome ameliorates intestinal-related metabolic conditions such as obesity, Crohn's disease (CD), and intestinal ulcerative colitis (IUC). In the future, further studies on the clinical level and model-based studies will warrant the use of flavonoids as better therapeutics and understanding of host health correlated with the microbiome.

类黄酮是水果和蔬菜中发现的多酚类化合物中的一种生物活性化合物。黄酮类化合物大多在消化道代谢,它们与肠道微生物群的相互作用是不可避免的。肠道菌群不断与膳食类黄酮相互作用,并将其分解为与宿主健康直接相关的更小的代谢物。肠道菌群具有弹性,高度依赖于环境实体,如外源抗生素、抗生素和饮食模式。这些外源性实体的任何突变都会引起肠道生态失调,导致不同的异常和失调。黄酮类化合物改变肠道中厚壁菌门和拟杆菌门的比例,这些细菌在宿主生理上起着决定性的作用。这篇综述引起了人们对黄酮类化合物如何改善肠道生态失调和炎症的关注。此外,我们还讨论了肠道生态失调发生前后的生物标志物和细胞信号。最后,我们强调黄酮类介导的肠道微生物群如何改善肠道相关代谢状况,如肥胖、克罗恩病(CD)和肠溃疡性结肠炎(IUC)。在未来,进一步的临床水平研究和基于模型的研究将保证黄酮类化合物作为更好的治疗药物和理解与微生物组相关的宿主健康。
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引用次数: 0
Cow's Milk Positively Impacts Bone Formation by Regulating the Osteocalcin Pathway Compared to Transgenic and Non-Transgenic Soy-Based Beverages in BALB/c Mice 与转基因和非转基因大豆饮料相比,牛奶通过调节骨钙素途径积极影响BALB/c小鼠的骨形成。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70369
Eduarda Pires Costa, Mariáurea Matias Sarandy, Amanda Alves Lozi, Maria Tatiana Soares Martins, Patricia da Silva Mattosinhos, Manoela Maciel dos Santos Dias, Sergio Luis P. Matta, Romulo Dias Novaes, Reggiani Vilela Gonçalves

Bone health is influenced by nutrition, with milk being one of the main dietary sources of calcium. However, many people are reducing their milk intake in favor of plant-based alternatives. This study compares the effects of cow's milk and soy-based beverage supplementation on femur morphofunctional parameters in BALB/c mice. The animals were randomized into four groups treated for 42 days with distilled water (G1), non-transgenic soy drink (G1), transgenic soy drink (G1), and cow's milk (G1). After euthanasia, femurs were collected for morphological and biomechanical analyses. G3 animals exhibited reduced phosphorus levels, cortical and trabecular thickness, diaphyseal diameter, type I collagen content, and increased porosity in the cortical bone. Conversely, G4 animals showed greater trabecular density (+20%), bone area (+20%), and trabecular width (+150%), as well as lower volume density of the medullary canal and trabecular separation. These animals also exhibited increased osteocalcin immunostaining, magnesium, phosphorus, and calcium levels; reduced diaphyseal porosity; and increased bone weight, suggesting that cow's milk positively impacts bone formation by stimulating osteocalcin production (+5%), especially compared to transgenic soy-based beverages. Therefore, our findings indicate that cow's milk may offer a safer alternative to soy-based beverages for promoting bone health.

骨骼健康受到营养的影响,牛奶是钙的主要膳食来源之一。然而,许多人正在减少牛奶的摄入量,转而选择植物性替代品。本研究比较了补充牛奶和大豆饮料对BALB/c小鼠股骨形态功能参数的影响。随机分为4组,分别饲喂蒸馏水(G1)、非转基因豆饮料(G1)、转基因豆饮料(G1)、牛奶(G1),试验期42 d。安乐死后,收集股骨进行形态学和生物力学分析。G3动物的磷水平、皮质和小梁厚度、骨干直径、I型胶原含量降低,皮质骨孔隙度增加。相反,G4动物的小梁密度(+20%)、骨面积(+20%)和小梁宽度(+150%)更高,髓管体积密度和小梁分离更低。这些动物也表现出骨钙素免疫染色、镁、磷和钙水平升高;干骺端孔隙度降低;并且增加了骨骼重量,这表明牛奶通过刺激骨钙素的产生(+5%)对骨骼形成有积极的影响,特别是与转基因大豆饮料相比。因此,我们的研究结果表明,在促进骨骼健康方面,牛奶可能比大豆饮料更安全。
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引用次数: 0
Partial Replacement of Maltodextrin With Galactose in Post-Weaning Diets of Mice Alters Body Composition and Energy Metabolism in Early-Life and Programs Hepatic Igf1 Expression in Later-Life 断奶后用半乳糖部分替代麦芽糖糊精可以改变小鼠早期的身体组成和能量代谢,并影响晚年肝脏Igf1的表达。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70361
Peixin Sun, Maryam Rakhshandehroo, Melissa Bekkenkamp-Grovenstein, Lidewij Schipper, Jaap Keijer, Evert M. van Schothorst

Galactose, a component of lactose, has nutritional programming power in mice. Lactose-free formulae contain maltodextrin, but no galactose. Here, partly replacing maltodextrin with galactose in the post-weaning diet was investigated for its metabolic and nutritional programming effects. Female and male mice were fed 39 energy% (en%) maltodextrin and 8 en% glucose (CON), or 31 en% maltodextrin with 16 en% galactose (GAL), or 15 en% maltodextrin and 16 en% galactose plus 16 en% glucose (lactose-mimic, LM) from postnatal week (PW) 3 to PW6. Body weight, fat mass, lean mass, energy expenditure (EE), and respiratory exchange ratio (RER) were lower at PW6 in female GAL and LM mice (p < 0.05). After receiving 9 weeks of the same obesogenic high-fat diet, the expression of hepatic insulin-like growth factor 1 (Igf1) appeared lower in both galactose-fed groups in females (p < 0.05). Partly replacing maltodextrin with galactose or galactose plus glucose in a post-weaning diet in mice resulted in significantly lower body weight, fat and lean mass, EE, and RER in early-life, and had no obvious nutritional programming effects except on liver Igf1 mRNA in females in later-life. The implications of this programming effect remain to be investigated further.

半乳糖是乳糖的一种成分,在小鼠体内具有营养编程能力。无乳糖配方含有麦芽糊精,但不含半乳糖。本研究对断奶后饲粮中用半乳糖部分替代麦芽糖糊精的代谢和营养规划效果进行了研究。从出生后第3至第6周,雌性和雄性小鼠分别饲喂能量为39% (en%)的麦芽糊精和8%的葡萄糖(CON),或31%的麦芽糊精加16%的半乳糖(GAL),或15%的麦芽糊精和16%的半乳糖加16%的葡萄糖(LM)。雌性GAL和LM小鼠的体重、脂肪质量、瘦质量、能量消耗(EE)和呼吸交换率(RER)在PW6时均较低(p < 0.05)。饲喂相同致肥性高脂饲料9周后,半乳糖饲喂两组雌性小鼠肝脏胰岛素样生长因子1 (Igf1)表达均降低(p < 0.05)。断奶后用半乳糖或半乳糖加葡萄糖部分替代麦芽糖糊精,可以显著降低小鼠早期体重、脂肪和瘦肉质量、EE和RER,除了对雌性小鼠晚年肝脏Igf1 mRNA的影响外,没有明显的营养编程效应。这种编程效应的影响还有待进一步研究。
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引用次数: 0
Anti-Inflammatory Properties of Ripe and Unripe Papaya Pectin in a Neonatal Human Stem Cell-Derived Ileum Model 成熟和未成熟木瓜果胶在新生儿干细胞衍生回肠模型中的抗炎特性。
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70379
Janaina Lombello Santos Donadio, João Paulo Fabi, Helena M. Crowley, Marcelo B. Sztein, Rosângela Salerno-Gonçalves

Pectin, a dietary fiber found in fruits and vegetables, has recognized anti-inflammatory properties. While papaya is rich in pectin, the impact of different ripening stages on its anti-inflammatory effects within the human neonatal gastrointestinal tract remains unexplored. Ripe and unripe papaya contain structurally distinct pectins, potentially leading to differing anti-inflammatory effects. Herein, ripe and unripe papaya pectins were tested in an in vitro model of human neonatal intestinal mucosa, in the presence or absence of commensal Escherichia coli (E. coli) as a surrogate for early intestinal colonizers. Papaya pectin enhanced cell viability regardless of ripening stage or the presence of E. coli. Both pectins reduced the IL-6 production in cultures exposed to E. coli, but only unripe pectin decreased IL-8 levels. Additionally, treatment with either pectin downregulated genes related to tight junctions and innate immune signaling (e.g., claudin-3, catenin-1, catenin-3, SUGT1, TRAF6, and NLRP3) in the presence of E. coli. Dimensionality reduction analyses further suggest that pectin induced distinct transcriptional profiles depending on the presence of bacteria. These results demonstrate that papaya pectin modulates epithelial barrier in a manner dependent on ripening stage and microbial context, providing novel insights into its functional and stage-specific anti-inflammatory activity.

果胶是一种在水果和蔬菜中发现的膳食纤维,具有公认的抗炎特性。虽然木瓜富含果胶,但不同的成熟阶段对其在人类新生儿胃肠道内的抗炎作用的影响仍未被探索。成熟和未成熟的木瓜含有结构不同的果胶,可能导致不同的抗炎作用。在此,成熟和未成熟的木瓜果胶在人类新生儿肠粘膜的体外模型中进行了测试,在存在或不存在共生大肠杆菌(E. coli)的情况下作为早期肠道定植菌的替代物。木瓜果胶提高细胞活力,无论成熟阶段或大肠杆菌的存在。两种果胶都降低了大肠杆菌培养物中IL-6的产生,但只有未成熟的果胶降低了IL-8的水平。此外,在大肠杆菌存在的情况下,果胶可以下调与紧密连接和先天免疫信号相关的基因(例如,claudin-3、catenin-1、catenin-3、SUGT1、TRAF6和NLRP3)。降维分析进一步表明,果胶诱导不同的转录谱取决于细菌的存在。这些结果表明,木瓜果胶以一种依赖于成熟阶段和微生物环境的方式调节上皮屏障,为其功能和阶段特异性抗炎活性提供了新的见解。
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引用次数: 0
Rice Starch–Purple Red Rice Bran Anthocyanins Complex Improves Glucose–Lipid Homeostasis and Restores Gut Microbiota in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice 米淀粉-紫红米糠花青素复合物改善高脂肪饮食/链脲佐菌素诱导的2型糖尿病小鼠的葡萄糖-脂质稳态和恢复肠道微生物群
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70384
Weidong Zhang, Mingyue Shen, Jieqiong Lin, Ting Chen, Shiru Mo, Qiang Yu, Yi Chen, Jianhua Xie

Purple red rice bran, a nutrient-rich byproduct of rice processing, contains abundant anthocyanins that distinguish it from ordinary bran and may offer metabolic benefits, while previous in vitro work has revealed that anthocyanins can form V-shaped inclusion complexes with rice starch (S-A), thereby enhancing resistant starch content and stimulating the growth of beneficial gut bacteria. However, the in vivo effects remain unclear. Therefore, using a high-fat diet/streptozotocin-induced T2DM mouse model to assess the metabolic impact of S-A, the results showed that dietary supplementation with S-A regulated glucose-lipid homeostasis, significantly reducing serum total cholesterol (5.98 ± 1.02→3.21 ± 1.07 mmol/L) and low-density lipoprotein cholesterol (3.25 ± 0.67→1.15 ± 0.74 mmol/L), with histopathological analysis revealing alleviated hepatic steatosis, renal fibrosis, and adipocyte hypertrophy; moreover, S-A reshaped the gut microbiota by enriching beneficial taxa, suppressing pathogens, and elevating short-chain fatty acids, while predictive functional analysis indicated restoration of microbial pathways involved in energy and amino acid metabolism. Overall, S-A exerts multifaceted regulation of lipid-glucose metabolism and gut microbiota, mitigating metabolic dysfunction in diabetic mice, and these findings underscore its potential as a novel functional dietary intervention while promoting the value-added utilization of purple red rice bran in managing metabolic disorders.

紫红米糠是一种营养丰富的大米加工副产品,含有丰富的花青素,与普通米糠不同,可能具有代谢益处,而先前的体外研究表明,花青素可以与大米淀粉(S-A)形成v形包合物,从而提高抗性淀粉含量,刺激有益肠道细菌的生长。然而,体内效应尚不清楚。因此,采用高脂饮食/链脲霉素诱导的T2DM小鼠模型来评估S-A的代谢影响,结果表明,膳食中添加S-A可调节糖脂稳态,显著降低血清总胆固醇(5.98±1.02→3.21±1.07 mmol/L)和低密度脂蛋白胆固醇(3.25±0.67→1.15±0.74 mmol/L),组织病理学分析显示肝脏脂肪变性、肾脏纤维化和脂肪细胞肥大得到缓解;此外,S-A通过丰富有益类群、抑制病原体和提高短链脂肪酸来重塑肠道微生物群,而预测功能分析表明,S-A可以恢复参与能量和氨基酸代谢的微生物途径。综上所述,S-A对糖脂代谢和肠道微生物群具有多层调控作用,可减轻糖尿病小鼠的代谢功能障碍,这些发现强调了S-A作为一种新型功能性饮食干预的潜力,同时促进了紫红米糠在代谢紊乱治疗中的增值利用。
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引用次数: 0
Association Between the Dutch Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND-NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study 一项探索性研究:荷兰-地中海饮食方法停止高血压干预神经退行性延迟(MIND-NL)饮食依从性与认知能力下降风险老年人系统性色氨酸代谢物之间的关系
IF 4.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-16 DOI: 10.1002/mnfr.70377
Sonja Beers, Lisette C. P. G. M. de Groot, Mark R. van Loenen, Lianne B. Remie, Mechteld Grootte Bromhaar, Andrea Anesi, Urska Vrhovsek, Joukje M. Oosterman, Esther Aarts, Mara P. H. van Trijp, Yannick Vermeiren

Tryptophan (TRP) metabolism is emerging as a focus of investigation in Alzheimer's disease research. In addition, diet might impact TRP's metabolic fate. The aim of this study was to explore the association between adherence to the Dutch Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND-NL) diet and systemic TRP metabolite levels and their related ratios in older adults at risk of cognitive decline. Data of the HELI multidomain lifestyle intervention study (n = 82) were used. Dietary intake data (FFQ) and fasted plasma levels were collected at baseline and 26 weeks follow-up. Bivariate Latent Change Score Models (LCSMs) were applied to assess both level-level and change-change associations, adjusted for lifestyle factors. Changes in MIND-NL diet adherence were significantly inversely associated with changes in the kynurenine:large neutral amino acids ratio (path coefficient −0.457, SE:0.206, p = 0.03) and kynurenine:tryptophan ratio (path coefficient −0.558 SE:0.235, p = 0.02). In addition, MIND-NL diet adherence was associated with lower levels of the neurotoxic metabolite quinolinic acid (path coefficient −0.186, SE:0.0700, p = 0.008), but within the crude model only. Our findings suggest that greater adherence to the MIND-NL diet may contribute to decreased activation of the kynurenine pathway.

色氨酸(TRP)代谢是阿尔茨海默病研究的热点。此外,饮食可能会影响TRP的代谢命运。本研究的目的是探讨荷兰地中海饮食方法停止高血压(DASH)干预神经退行性延迟(MIND-NL)饮食与系统性TRP代谢物水平及其相关比率在认知能力下降风险的老年人中的关系。采用HELI多领域生活方式干预研究(n = 82)的数据。在基线和26周随访时收集饮食摄入数据(FFQ)和空腹血浆水平。采用双变量潜在变化评分模型(lcsm)评估水平-水平和变化-变化相关性,并根据生活方式因素进行调整。MIND-NL饮食依从性的变化与犬尿氨酸:大中性氨基酸比值(通径系数-0.457,SE:0.206, p = 0.03)和犬尿氨酸:色氨酸比值(通径系数-0.558 SE:0.235, p = 0.02)的变化呈显著负相关。此外,MIND-NL饮食依从性与较低水平的神经毒性代谢物喹啉酸相关(通道系数-0.186,SE:0.0700, p = 0.008),但仅在粗模型内。我们的研究结果表明,坚持MIND-NL饮食可能有助于减少犬尿氨酸途径的激活。
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Molecular Nutrition & Food Research
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