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Experience of Prevalence of Thyroid Carcinoma in Thyroid Swelling 甲状腺肿大中甲状腺癌发病率的经验
Pub Date : 2023-11-08 DOI: 10.36348/sjmps.2023.v09i11.003
Dr. Bashudeb Kumar Saha, Dr. I.M. Hashim, Dr. Md. Iqbal Hossen, Senior Consultant
Objective: In this study our main goal is to observe the experience of prevalence of thyroid carcinoma in thyroid swelling. Method: This retrospective study was carried out at tertiary hospital, Dhaka Bangladesh from July, 2021 to December 2022. Total 95 patients with thyroid swelling with normal thyroid hormone profile undergoing thyroidectomy were included as a sample population. Results: Among the 95 patients highest 23 (24.21%) patients age was (31-40) years. highest 55 (58%) patients were female and 40 (42%) patients were male. highest 42 (44%) patients had Only thyroid swelling and similar 42 (44%) patients had both thyroid+Lymph node enlargement. patients highest 90 (95%) patients had local metastatic and only 5 (5%) had distant metastatic. 58.95% had no complication on surgery. Conclusion: From our study we can say that, both the initial treatment and follow-up should be individualized according to prognostic indicators and any subsequent evidence of disease.
研究目的本研究的主要目的是观察甲状腺肿大中甲状腺癌的发病率。研究方法这项回顾性研究于2021年7月至2022年12月在孟加拉国达卡的三级医院进行。共有95名甲状腺肿大且甲状腺激素水平正常的患者接受了甲状腺切除术。结果最多有55名(58%)患者为女性,40名(42%)患者为男性。最多有42名(44%)患者只有甲状腺肿大,类似的42名(44%)患者同时有甲状腺+淋巴结肿大。最多有90名(95%)患者有局部转移,只有5名(5%)患者有远处转移。58.95%的患者没有手术并发症。结论从我们的研究中可以看出,无论是初始治疗还是后续治疗,都应根据预后指标和任何后续疾病证据进行个体化治疗。
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引用次数: 0
Pterygium Recurrence Prevention Utilizing Mitomycin C Washing, Case Series 利用丝裂霉素C清洗预防翼状胬肉复发,病例系列
Pub Date : 2023-11-06 DOI: 10.36348/sjmps.2023.v09i11.002
Luis Juan, Rafael Francisco, Frida Antonio, Lucia Fernado
Objective: To assess the effects of 0.20 mg of mitomycin C washing on the pterygium recurrence. Methodology: A total of 15 individuals were included in this observational retrospective analysis. They underwent pterygium surgery using 0.20 mg of mitomycin C and a graft. The postoperative care given to each group was the same. Results: There were no recurrences, with a P-value of 0.000. Conclusion: This case series indicates that just washing the bare sclera with MMC is effective against recurrence.
目的:探讨0.20 mg丝裂霉素C洗涤对翼状胬肉复发的影响。方法:本观察性回顾性分析共纳入15例个体。他们接受了翼状胬肉手术,使用0.20毫克丝裂霉素C和移植物。各组术后护理相同。结果:无复发,p值为0.000。结论:本病例提示单纯用MMC清洗裸露巩膜可有效预防复发。
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引用次数: 0
Antibacterial Activity of Mentha piperita (Peppermint) Oil against Wound Infections Caused by Carbapenem-Resistant Klebsiella in Rats 薄荷油对耐碳青霉烯克雷伯菌所致大鼠创面感染的抗菌作用
Pub Date : 2023-11-02 DOI: 10.36348/sjmps.2023.v09i11.001
Fahad Alturaiki, Babu Joseph, Fahad Mohammed Asad
Drug resistant Klebsiella pneumoniae causes nosocomial infections, pneumonia, wound sepsis and infections of newborns and intensive care patients. In many cases antibiotics are no longer very effective in patients treated for K. pneumoniae infections. Various studies have shown antimicrobial properties of essential oils and different compounds that are part of them. This study aimed to determine the antibacterial efficacy and minimum inhibitory concentration of the Mentha piperita essential oil against resistant strain of K. pneumoniae. Efficiency of peppermint oil when used with antibiotics in wound management as well as controlling K. pneumoniae infection was also investigated in this study. Well diffusion method was used to determine the antibacterial activity of peppermint oil, where its inhibitory capacity was observed along with antibiotics and compared with control. Bacterial load of K. pneumonia OXA48 resistant strain on wound in rat models was also studied and compared. Klebsiella pneumoniae OXA48 and K. pneumoniae ATCC 700603 were inhibited by effectively by 40 µl/ml of peppermint oil in well diffusion assays. In rat models the wounds were healed, and epithelization was quicker in 10% peppermint oil treated wounds. Wounds applied with a combination of peppermint oil and Imipenem were more effectively protected from infection and showed better healing as well. Peppermint oil depicted both inhibitory capacities against K. pneumonia OXA48 and promoted wound healing as well. Further studies regarding PMO and its efficacy in wound management as well as its associated molecular mechanism would provide better understanding regarding its potential.
耐药肺炎克雷伯菌引起医院感染、肺炎、伤口败血症以及新生儿和重症监护患者感染。在许多情况下,抗生素对治疗肺炎克雷伯菌感染的患者不再非常有效。各种研究表明,精油及其中不同的化合物具有抗菌特性。本研究旨在确定薄荷精油对肺炎克雷伯菌耐药菌株的抑菌效果和最低抑菌浓度。本研究还探讨了薄荷油与抗生素在伤口管理和控制肺炎克雷伯菌感染中的效果。采用孔扩散法测定薄荷油的抑菌活性,并将其与抗生素的抑菌能力进行比较。研究并比较肺炎克雷伯菌OXA48耐药菌株在大鼠创面上的细菌负荷。40µl/ml薄荷油能有效抑制肺炎克雷伯菌OXA48和肺炎克雷伯菌ATCC 700603。在大鼠模型中,10%薄荷油处理的伤口愈合,上皮形成更快。在伤口上涂抹薄荷油和亚胺培南,可以更有效地防止感染,并显示出更好的愈合。薄荷油既能抑制肺炎克雷伯菌OXA48,又能促进伤口愈合。进一步研究PMO及其在伤口治疗中的作用及其相关分子机制将有助于更好地了解其潜力。
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引用次数: 0
To Asses Maternal Morbidity and Mortality of Induced Abortion among Admitted Cases in Rajshahi Medical College Hospital, Rajshahi 评估拉杰沙希医学院医院住院病例中产妇人工流产的发病率和死亡率
Pub Date : 2023-10-31 DOI: 10.36348/sjmps.2023.v09i10.007
Marzina Khatun, Shadia Sharmin Sultana, Rehana Parven, Sharifa Begum, Mousumee Mondal
Background: Abortion is pregnancy termination before the 24th week. Unsafe induced abortions, lacking proper skills or medical standards, cause 67,000 annual deaths in developing countries, according to WHO. Ensuring access to safe and legal abortion services is critical to reducing maternal mortality and safeguarding women's health globally. Objectives: The aim of this study was to find out maternal mortality as well as morbidity related to induce abortion for termination of unwanted pregnancy in our set up. Methods: A cross-sectional study was conducted on 92 patients who admitted as cases of induced abortion in Rajshahi Medical College Hospital from March' 2014 to September 2014Those who had given informed written consent was finally enrolled in this study. Patients' details history, clinical examination investigation, and operation note was collected in a preformed data sheet. Data was presented in the form of tables and graphs. Data was presented with descriptive statistics the level of significance of 0.05 was used for this study. Results: Among 92 patients were 15(16.3%) hemorrhage, 9(9.8%) hypovolemic shock, 10(10.9%) generalized peritonitis, 34(36.9%) pelvic peritonitis5 (5.4%) perforation of uterus, 4(4.3%) cervical injury, 1(1.1%) perforation of gut, 2(2.2%) septic shock, 2(2.2%) acute renal failure, 10(10.9%) no major complication. Among 92 patient 86 (93.5%) patients were improved and discharged and 6(6.5%) patients were expired. Conclusion: Induced abortion is a common gynecological problem requiring hospital admission and treatment. It has serious short term and long-term complications affecting women's health and life.
背景:流产是指24周前终止妊娠。据世卫组织称,缺乏适当技能或医疗标准的不安全人工流产在发展中国家每年造成6.7万人死亡。确保获得安全和合法的堕胎服务对于在全球降低孕产妇死亡率和保障妇女健康至关重要。目的:本研究的目的是了解在我们的设置中,与人工流产终止意外妊娠相关的孕产妇死亡率和发病率。方法:对2014年3月至2014年9月在Rajshahi医学院附属医院住院的92例人工流产患者进行横断面研究,经知情书面同意的患者最终入选本研究。将患者的详细病史、临床检查调查和手术记录收集在预先编制的数据表中。数据以表格和图表的形式呈现。资料采用描述性统计,本研究采用显著性水平0.05。结果:92例患者中出血15例(16.3%),低血容量性休克9例(9.8%),全身性腹膜炎10例(10.9%),盆腔腹膜炎34例(36.9%),子宫穿孔5例(5.4%),宫颈损伤4例(4.3%),肠穿孔1例(1.1%),感染性休克2例(2.2%),急性肾功能衰竭2例(2.2%),无重大并发症10例(10.9%)。92例患者好转出院86例(93.5%),死亡6例(6.5%)。结论:人工流产是妇科常见病,需要住院治疗。它具有严重的短期和长期并发症,影响妇女的健康和生活。
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引用次数: 0
Pneumonia Infection Incidence with Enteral Feeding in Intensive Care Patients 重症监护患者肠内喂养后肺炎感染的发生率
Pub Date : 2023-10-29 DOI: 10.36348/sjmps.2023.v09i10.006
Mashael Alharbi, Kamal K. Alsofyani, Mohammed Alshehri, Rakan Alshareef, Osama A. Alshehri, Saad Alsaad, Nuha M. Barnawi
Background: Enteral nutrition (EN) is the administration of a nutritionally complete feed through a tube into the stomach, duodenum, or jejunum. It has been proposed that EN helps to maintain the health and integrity of the gut barrier and is connected to increased levels of immunoglobulin synthesis, which may help to boost defenses against respiratory infections. However, critically ill patients may have a poor tolerance for enteral feeding and may develop unpleasant gastrointestinal effects such as nausea and vomiting. Aim: To investigate at the incidence between enteral nutrition and the risk of pneumonia in intensive care unit patients. Methods: This is an updated review of research that were published between 2016 and 2018. To research our topic, we employed the Google Scholar, Web of Science, and PubMed databases. The keywords used in various combinations included "enteral nutrition, feeding, incidence, aspiration, pneumonia, adults, ICU." In addition, original research on the relationship between entreat feeding and the risk of pneumonia in critically ill individuals was reviewed. The inclusion criterion was full-text publications. Results: Despite obtaining 17 papers, only three research met the inclusion requirements. All of the research were conducted in the past. The study included 413 adult patients in the intensive care unit. Conclusion: In critically ill people, enteral feeding was related with a lower risk of aspiration pneumonia and overall infections. Enteral feeding was found to be safe and effective for critically ill patients, with no major problems.
背景:肠内营养(EN)是指通过一根管子将营养完全的饲料注入胃、十二指肠或空肠。有人提出,EN有助于维持肠道屏障的健康和完整性,并与免疫球蛋白合成水平的提高有关,这可能有助于增强对呼吸道感染的防御。然而,危重病人对肠内喂养的耐受性可能较差,并可能出现恶心和呕吐等不愉快的胃肠道反应。目的:探讨重症监护病人肠内营养与肺炎发生风险的关系。方法:这是对2016年至2018年发表的研究的最新综述。为了研究我们的主题,我们使用了Google Scholar、Web of Science和PubMed数据库。在各种组合中使用的关键词包括“肠内营养、喂养、发病率、误吸、肺炎、成人、ICU”。此外,对危重患者恳求性喂养与肺炎风险关系的原始研究进行了综述。纳入标准为全文出版物。结果:虽然获得了17篇论文,但只有3篇研究符合纳入要求。所有的研究都是在过去进行的。该研究包括重症监护病房的413名成年患者。结论:在危重患者中,肠内喂养与吸入性肺炎和整体感染的风险较低有关。发现肠内喂养对危重患者安全有效,无重大问题。
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引用次数: 0
In-Silico Validation of Niazinin-A Against Proinflammatory Mediator: Anti-Proliferative Potential Niazinin-A抗促炎介质的计算机验证:抗增殖潜能
Pub Date : 2023-10-25 DOI: 10.36348/sjmps.2023.v09i10.005
Shobharam Sahu, Chhaya Rathor Sahu, Divakar Kanakagiri, Jitender Kumar Malik
Background: Cancer is one of the most dreaded human diseases, that has become an ever-increasing health problem and is a prime cause of death globally. Munga, also known as Moringa oleifera Lam., is one of the most significant plants grown extensively in India. This plant, Moringa oleifera Lam, is used extensively as a dietary supplement and has valuable pharmacological properties including anti-asthmatic, anti-diabetic, hepatoprotective, anti-inflammatory, anti-cancer, antimicrobial, anti-oxidant, cardiovascular, anti-ulcer, CNS activity, anti-allergic, wound healing, analgesic, and antipyretic action. This plant has great therapeutic properties in every area. It is a good source of milk protein, vitamin A, and vitamin C. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil, and lipids are only a few examples of the several active phytoconstituents that are present. Aim: The current work sought to elucidate the molecular basis for Niazinin A antiproliferative activity against the VEGF-1 & AURKA, which functions as a proinflammatory factor in proliferation. Method: A molecular docking method was employed in the current work to look for VEGFR-1 & AURKA protein inhibitors. The binding was determined by the Auto Dock software utilising a grid-based docking method. Results: The molecular docking result revealed that Niazinin A showed encouraging docking score. The docking score found to be -7& -6.11 for VEGF-1 & AURKA kcal mol–1 respectively. Conclusion: The interaction of ligand hits to targeted site and docking score finding it can be predicted that Niazinin A found in the plants Moringa exhibited good inhibitor of VEGF-1 & AURKA protein.
背景:癌症是人类最可怕的疾病之一,它已成为一个日益严重的健康问题,是全球死亡的主要原因。芒加,又名辣木。是印度广泛种植的最重要的植物之一。这种植物辣木(Moringa oleifera Lam)被广泛用作膳食补充剂,具有抗哮喘、抗糖尿病、保护肝脏、抗炎、抗癌、抗菌、抗氧化、心血管、抗溃疡、中枢神经系统活性、抗过敏、伤口愈合、镇痛和解热等药理作用。这种植物在各个方面都有很好的治疗作用。它是牛奶蛋白、维生素a和维生素c的良好来源。生物碱、蛋白质、奎宁、皂苷、类黄酮、单宁、类固醇、糖苷、固定油和脂质只是存在的几种活性植物成分中的几个例子。目的:本研究旨在阐明Niazinin A抗VEGF-1活性的分子基础;AURKA,它在增殖过程中起到促炎因子的作用。方法:本研究采用分子对接方法寻找VEGFR-1;AURKA蛋白抑制剂。绑定由Auto Dock软件利用基于网格的对接方法确定。结果:分子对接结果显示,Niazinin A具有较高的对接分数。对接得分为-7;-6.11为VEGF-1 &分别为AURKA kcal mol-1。结论:通过配体与靶部位的相互作用和对接评分,可以预测辣木中发现的Niazinin A具有良好的VEGF-1抑制剂作用;AURKA蛋白质。
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引用次数: 0
Challenges of Health Informatics Systems in Primary Health Care 初级卫生保健卫生信息系统的挑战
Pub Date : 2023-10-13 DOI: 10.36348/sjmps.2023.v09i10.004
Amro A. Alamro, Mohammed S. Aljuma, Sami S. Alateeq, Nader M. Alharbi, Abdulaziz S. Alharbi, Rayan S. Alghufaili, Ahmed A. Alsharekh, Abdullah A. Alharbi
Health informatics systems are indispensable implements for cultivating the eminence and effectiveness of primary health care. Health informatics systems are formed of databases and figures regarding all clinical facilities. The utilization of health informatics systems helps both healthcare providers and patients in the management of disorders and disease risks and in developing well-being. However, there are a number of challenges to the application and practice of health informatics systems in the settings of primary health care. These challenges embrace; the absence of capital and money, the absence of technical skill, the absence of user recognition and approval, information quality problems, safety and confidentiality concerns, incorporation with other systems, and interoperability deficiency. Human, cultural, and financial barriers with deficiency of technical proficiency, deficiency of a relation between clinicians and patients, worries about information privacy, absence of administration guidelines, bureaucracy, lack of training, English language barrier, the degree of workload due to the time shortness during clinical settings, infrastructure concerns e.g. availability of the electricity, computers, and internet, also high turnover in IT among healthcare are also some challenges that should be addressed. These challenges can hold back the capacity of health informatics systems to comprehend their complete perspective in primary health care. To address these challenges, it is essential to provide sufficient capital and funds, offer practice and maintenance for users, overcome information quality concerns, apply safety and confidentiality procedures, incorporate health informatics systems with other systems, and endorse interoperability. By overcoming these challenges, health informatics systems can play a major role in developing the quality and efficiency of primary health care.
卫生信息系统是培养初级卫生保健卓越性和有效性不可或缺的工具。卫生信息系统由所有临床设施的数据库和数据组成。卫生信息系统的利用有助于卫生保健提供者和患者管理疾病和疾病风险,并发展福祉。然而,卫生信息系统在初级卫生保健环境中的应用和实践存在许多挑战。这些挑战包括:缺乏资金和资金、缺乏技术技能、缺乏用户认可和批准、信息质量问题、安全和保密问题、与其他系统合并以及互操作性不足。人力、文化和财务障碍,如技术熟练程度不足、临床医生和患者之间关系不足、对信息隐私的担忧、缺乏管理指南、官僚主义、缺乏培训、英语语言障碍、临床设置时间短导致的工作量程度、基础设施问题,如电力、计算机和互联网的可用性;医疗保健行业IT人员的高流动率也是一些需要解决的挑战。这些挑战会阻碍卫生信息系统全面理解初级卫生保健的能力。为应对这些挑战,必须提供足够的资本和资金,为用户提供实践和维护,克服信息质量问题,应用安全和保密程序,将卫生信息系统与其他系统结合起来,并认可互操作性。通过克服这些挑战,卫生信息系统可以在提高初级卫生保健的质量和效率方面发挥重要作用。
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引用次数: 0
A dragging Externotitis Hiding Tuberculosis of the External Ear 外耳拖拽性隐匿性外耳炎1例
Pub Date : 2023-10-06 DOI: 10.36348/sjmps.2023.v09i10.003
N. Belhaj, R. Bencheikh, M. A. Benbouzid, L. Houssayni, Essakalli Essakalli
Tuberculosis of the ear is rare; we report the case of an 86-year-old patient, followed for a dragging otitis resistant to local and general treatment whose clinical picture mimicked malignant extern otitis but during the biopsy of the polyp of the external auditory canal revived the diagnosis.
耳结核很少见;我们报告一个86岁的病人,跟随拖沓性中耳炎抵抗局部和一般治疗,其临床表现模仿恶性外耳炎,但在外耳道息肉活检期间恢复诊断。
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引用次数: 0
Scrub Typhus – An Emerging Public Health Threat in Northern India 丛林斑疹伤寒——印度北部新出现的公共卫生威胁
Pub Date : 2023-10-05 DOI: 10.36348/sjmps.2023.v09i10.002
Rahul Shil
Scrub typhus is not a recent disease. This was prominent before the era of World War II. However, the disease is primarily prevalent in the Pacific Islands and southeast Asia. The symptoms begin with fever, eschar development, and a rash. As a result, diagnosing the disease has become more complex because comparable symptoms can be observed in a variety of other conditions. Therefore, proper diagnostic tests are required to diagnose the condition. Scrub typhus infections are increasing in India every year, and several states are reporting an increase in cases. The disease mostly affects the gastrointestinal system, nervous system, renal systems, and respiratory systems; however, mortality can be minimized with early diagnosis and adequate treatment. As many people in India are unaware of the condition, raising awareness will help in the saving of many lives.
丛林斑疹伤寒不是最近才发生的疾病。这在第二次世界大战之前就很突出。然而,该病主要流行于太平洋岛屿和东南亚。症状开始是发烧、出现焦痂和皮疹。因此,诊断这种疾病变得更加复杂,因为可以在各种其他情况下观察到类似的症状。因此,需要适当的诊断测试来诊断病情。印度的丛林斑疹伤寒感染每年都在增加,几个邦报告的病例有所增加。该病主要影响胃肠道系统、神经系统、肾脏系统和呼吸系统;然而,通过早期诊断和适当治疗,死亡率可以降到最低。由于印度很多人都不知道这种情况,提高认识将有助于挽救许多生命。
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引用次数: 0
Ascertaining the Level of Psychological Effects of Delayed Menstrual Period among Female Students in Tertiary Institutions in South-South, Nigeria 尼日利亚南南高等院校女生月经延迟的心理影响程度
Pub Date : 2023-10-02 DOI: 10.36348/sjmps.2023.v09i10.001
Gbaranor, K. B, Dickson, I. C, Okocha, A. N, Mube, W. A, Ile, V. I, Kinako, S. E, Dimkpa, B. M, Oluoha, R. U, Kue, D. S, Dimkpa, C. R, Chris-Biriowu H., George, A. F, Nwogu H. C, Pepple, B. G
Menstrual period is a monthly activity that every woman who has attained the age of puberty experienced. It is a natural process and when it does not show or come, the woman in question will be worried and until the root cause of the delayed or stoppage is known and if possible, rectify the cause of the abnormally, the woman will not be happy. The aim of the study is Ascertaining the Level of Psychological Effects of Delayed Menstrual Period Among Female Students in Tertiary Institutions in South South, Nigeria. The study was a cross-sectional study and a total of 250 female students within participated in the study. A well-structured questionnaire was distributed to each participant by the research assistant after consent was granted by the participants. The study was carried out in the six States that make up South-South Geopolitical Zones and it lasted for a period of 3 months. The findings revealed that 243(97.20%) of the participants affirmed being depressed as a result of delayed menstrual period while 7(2.80%) disagreed being depressed due to delayed menstrual period. Also, 240(96.00%) of the respondents isolated themselves due to delayed menstrual period. The results shows that 238(95.20%) of the respondents were ashamed due to delayed menstrual period and 239(95.60%) were deeply thinking. The research revealed that 240(96.00%) of the participants agreed that delayed menstrual period affects their academic performance and 243(97.20%) of the respondents worried about the delayed in their menstrual period. The data were analysed using SPSS version 23 and P < 0.05 was said to be significant.
月经是每个达到青春期年龄的女性都经历过的每月一次的活动。这是一个自然的过程,当它没有出现或出现时,女性就会担心,直到知道延迟或停止的根本原因,如果可能的话,纠正异常的原因,女性才会高兴。本研究的目的是确定尼日利亚南南高等院校女学生月经延迟的心理影响程度。本研究是一项横断面研究,共有250名女学生参与了研究。在得到参与者的同意后,研究助理向每位参与者分发了一份结构良好的问卷。这项研究在构成南南地缘政治区的六个国家进行,为期3个月。结果显示,243人(97.20%)认为月经推迟导致抑郁,7人(2.80%)认为月经推迟导致抑郁。此外,240名(96.00%)受访者因月经推迟而自我隔离。结果显示,238人(95.20%)因月经推迟而感到羞愧,239人(95.60%)因月经推迟而陷入深思。研究发现,240名(96.00%)的受访者认为月经推迟会影响他们的学习成绩,243名(97.20%)的受访者担心月经推迟。数据分析采用SPSS version 23和P <0.05被认为是显著的。
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引用次数: 0
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Saudi Journal of Medical and Pharmaceutical Sciences
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