Schizophrenia Research最新文献_第4页

16p11.2 duplication syndrome-associated psychosis: An illustrative case and review of the literature 16p11.2 重复综合征相关性精神病：一个典型病例和文献综述。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.006

Mark Ainsley Colijn

引用次数: 0

Autism-spectrum quotient mediates the relationship between clinical symptoms and quality of life in schizophrenia 自闭症谱系商在精神分裂症患者临床症状与生活质量之间的关系中起中介作用。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.007

Miki Ishizuka , Sadao Otsuka , Jun Miyata , Yujiro Yoshihara , Manabu Kubota , Toshiya Murai

Background

Social dysfunctions can affect the quality of life (QOL) of patients with schizophrenia. The autism-spectrum quotient (AQ) is a widely used measure of innate autistic traits. However, in patients with schizophrenia, the score may represent the severity of autism-like social dysfunctions as a consequence of symptoms. We tested the hypothesis that AQ would mediate the relationship between clinical symptoms and QOL in patients with schizophrenia, based on the assumption that the AQ measures autism-like social dysfunctions rather than autistic traits in this population.

Methods

We analyzed data from 108 outpatients with schizophrenia. The relationships among the scores on the Positive and Negative Syndrome Scale (PANSS), the Schizophrenia Quality of Life Scale (SQLS), and the AQ were examined using structural equation modeling (SEM).

Results

Path analyses of the total scale scores revealed partial mediation, but not full mediation or independent effects. However, both the AQ and PANSS scores could be mediators. SEM including the three domain scores of PANSS, the two factors of the AQ, and the three subscale scores of the SQLS showed a good fit of the AQ mediation model, but not the symptom mediation model, supporting our hypothesis. In this final model, the relationship between negative symptoms and QOL was mediated by autism-like social dysfunctions, whereas positive symptoms directly affected QOL.

Conclusions

Our findings advance our understanding of what the AQ measures when applied to patients with schizophrenia and suggest that autism-like social dysfunctions are important treatment targets for improving QOL in this population.

背景：社交功能障碍会影响精神分裂症患者的生活质量。自闭症谱系商（autism-spectrum quotient， AQ）是一种被广泛使用的衡量先天性自闭症特征的方法。然而，在精神分裂症患者中，分数可能代表了自闭症样社交功能障碍的严重程度。我们测试了精神分裂症患者临床症状和生活质量之间关系的假设，该假设是基于精神分裂症患者的精神分裂症样社会功能障碍而不是自闭症特征的假设。方法：对108例精神分裂症门诊患者的资料进行分析。采用结构方程模型（SEM）分析精神分裂症患者正、负症候量表（PANSS）、生活质量量表（SQLS）和精神分裂症患者心理素质之间的关系。结果：总量表得分的通径分析显示部分中介作用，但没有完全中介作用或独立效应。然而，AQ和PANSS分数都可能是中介。SEM包括PANSS的三个域分数、AQ的两个因子和SQLS的三个子量表分数，对AQ的中介模型拟合较好，但对症状的中介模型不拟合，支持我们的假设。在最后一个模型中，阴性症状与生活质量之间的关系是由自闭症样社交功能障碍介导的，而阳性症状直接影响生活质量。结论：我们的研究结果促进了我们对应用于精神分裂症患者的AQ测量的理解，并表明自闭症样社交功能障碍是改善这一人群生活质量的重要治疗目标。

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引用次数: 0

Autistic trait severity in early schizophrenia: Role in subjective quality of life and social functioning 早期精神分裂症的自闭症特征严重程度：在主观生活质量和社会功能中的作用。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.003

Ayumu Wada , Risa Yamada , Yuji Yamada , Chika Sumiyoshi , Ryota Hashimoto , Junya Matsumoto , Akiko Kikuchi , Ryotaro Kubota , Makoto Matsui , Kana Nakachi , Chinatsu Fujimaki , Leona Adachi , Andrew Stickley , Naoki Yoshimura , Tomiki Sumiyoshi

Background

Cognitive impairment is a cardinal feature in patients with schizophrenia and leads to poor social functioning. Recently, the treatment of schizophrenia has evolved to include the goal of improving quality of life (QoL). However, most of the factors influencing subjective QoL are unknown. Autistic traits have been shown to co-occur with various psychiatric conditions including schizophrenia. Hence, the present study aimed to investigate whether cognitive function and autistic trait severity are associated with social functioning and subjective QoL in patients with early schizophrenia.

Methods

Data were analyzed from 183 outpatients diagnosed with early schizophrenia in Tokyo, Japan. Information was obtained on neurocognition with the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Autistic trait severity was assessed using the Autism Spectrum Quotient (AQ), while social functioning was measured with the Specific Levels of Functioning Scale Japanese version. Information was obtained on subjective QoL with the Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version. Multiple regression analysis was used to examined associations.

Results

In an analysis adjusted for demographic characteristics (age, sex and education), both autistic trait severity (β = -0.56, p < 0.01) and neurocognitive function (β = 4.37, p < 0.01) were significantly associated with social function. On the other hand, only autistic trait severity made a significant contribution to the prediction of subjective QoL (β = -1.79, p < 0.01).

Conclusions

The results of this study suggest that efforts to detect and treat cognitive impairment and comorbid autistic trait in early schizophrenia may be important for improving social functioning and subjective QoL in this population. In particular intervention that targets autistic trait severity seems to be key to achieving personal recovery in patients with schizophrenia.

背景：认知障碍是精神分裂症患者的主要特征，导致社会功能低下。最近，精神分裂症的治疗已经发展到包括提高生活质量（QoL）的目标。然而，大多数影响主观生活质量的因素是未知的。自闭症特征已被证明与包括精神分裂症在内的各种精神疾病共同发生。因此，本研究旨在探讨认知功能和自闭症特征严重程度是否与早期精神分裂症患者的社会功能和主观生活质量相关。方法：对日本东京183例早期精神分裂症门诊患者的资料进行分析。通过日文版《精神分裂症患者认知能力简要评估》获得神经认知方面的信息。自闭症特征的严重程度是用自闭症谱系商（AQ）来评估的，而社会功能是用日本版的特定功能水平量表来衡量的。获得抗精神病药物治疗后主观生活质量与主观幸福感的关系。采用多元回归分析检验相关性。结果：在人口统计学特征（年龄、性别和教育程度）调整后的分析中，自闭症特征严重程度（β = -0.56, p < 0.01）和神经认知功能（β = 4.37, p < 0.01）与社会功能显著相关。另一方面，只有自闭症特质严重程度对主观生活质量的预测有显著贡献（β = -1.79, p < 0.01）。结论：本研究结果表明，努力检测和治疗早期精神分裂症患者的认知障碍和共病自闭症特征可能对改善这一人群的社会功能和主观生活质量很重要。特别是针对自闭症特征严重程度的干预似乎是实现精神分裂症患者个人康复的关键。

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引用次数: 0

Highlights January

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/S0920-9964(25)00014-3

引用次数: 0

Disentangling the topological symptom structure of schizophrenia: A network analysis 解析精神分裂症的拓扑症状结构：网络分析。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.002

Jingjing Li , Lijuan Pang , Fang Liu , Zhe Lu , Yu Zhang , Yongfeng Yang , Xue Li , Qiushi Hu , Keju Su , Yishao Chen , Yan Zhang , Fangfang Zhao , Xueqin Song , Gangrui Hei

Background and hypothesis

The Positive and Negative Syndrome Scale (PANSS), comprehensively assesses schizophrenia severity. While network analyses of schizophrenic symptoms have yielded inconsistent results, components of disorganized thought consistently rank high in centrality. The present study aims to explore the centrality of disorganized thought across patient subgroups and its potential as a treatment target. We hypothesize that disorganized thought will emerge as a central feature in the symptom network across different patient populations.

Study design

We conducted a network psychometric analysis on data from 1435 schizophrenia patients, stratified into four groups based on family history and sex. Local and global network properties, including centrality, clustering coefficient, degree, density, and community detection, were investigated. Network comparisons were performed across groups, and results were validated using an independent dataset.

Study results

Disorganized thought emerged as the most central factor in Marder 5-factor model, maintaining stability across family history and sex differences. While family history did not significantly impact symptom structures (Females: M = 0.2, P = 0.4; S = 0.4, P = 0.7; Males: M = 0.2, P = 0.7; S = 0.1, P = 0.9), significant differences were observed between male and female symptom structures (Positive family history: M = 0.3, P < 0.05; Negative family history: M = 0.3, P < 0.01). The centrality and high stability of disorganized thought were further confirmed in the validation dataset.

Conclusions

The consistent centrality of disorganized thought across different patient subgroups suggests its potential as a key treatment target for schizophrenia.

背景与假设：Positive and Negative Syndrome Scale （PANSS）是一种综合评估精神分裂症严重程度的量表。虽然对精神分裂症症状的网络分析得出了不一致的结果，但无序思维的组成部分始终在中心性方面排名很高。本研究旨在探讨无组织思维在患者亚组中的中心地位及其作为治疗目标的潜力。我们假设，在不同的患者群体中，无组织思维将作为症状网络的中心特征出现。研究设计：我们对1435名精神分裂症患者的数据进行了网络心理测量分析，根据家族史和性别将其分为四组。研究了局部和全局网络特性，包括中心性、聚类系数、程度、密度和社区检测。跨组进行网络比较，并使用独立数据集验证结果。研究结果：无序思维成为Marder五因素模型的最核心因素，在家族史和性别差异中保持稳定。而家族史对症状结构无显著影响(女性：M = 0.2, P = 0.4；S = 0.4, p = 0.7；男性：M = 0.2, P = 0.7；S = 0.1, P = 0.9)，男性和女性症状结构存在显著差异（阳性家族史：M = 0.3， P）。结论：在不同患者亚组中，无序思维的中心性一致，表明其可能是精神分裂症的关键治疗靶点。

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引用次数: 0

Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood 母亲精神分裂症与儿童时期严重哮喘恶化风险之间的关系

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.11.008

J.G. Pouget , E. Cohen , J.G. Ray , A.S. Wilton , H.K. Brown , N.R. Saunders , C.L. Dennis , A.C. Holloway , K.M. Morrison , G.E. Hanley , T.F. Oberlander , A. Bérard , K. Tu , L.C. Barker , S.N. Vigod

Background and hypothesis

While maternal schizophrenia is linked to chronic childhood medical conditions, little is known about the risk of acute asthma exacerbations among children whose mothers have schizophrenia. This population-based study used health data for all of Ontario, Canada to evaluate whether having a mother with schizophrenia was associated with increased risk of asthma exacerbations.

Study design

The study cohort included 385,989 children diagnosed with asthma from age 2 years onward, followed from the time of their asthma diagnosis up to a maximum of age 19 years. Children whose biological mother was diagnosed with schizophrenia prior to the child's asthma diagnosis (n = 1407) were compared children whose mother was not (n = 384,582). Study outcomes were asthma-related hospitalization, and separately, asthma-related emergency department (ED) visit, each up to a maximum child age of 19 years. First exacerbations were evaluated using Cox proportional hazards models, and recurrent exacerbations by Andersen-Gill regression, adjusted for covariates.

Study results

First hospitalization for an asthma exacerbation occurred in 76 (6.9 per 1000 person-years) vs. 19,679 (5.4 per 1000 person-years) children with and without maternal schizophrenia (adjusted hazard ratio [aHR] 1.21, 95 % CI 0.97–1.51). For first asthma-related ED exacerbations, the rates were 25.1 vs. 20.7 per 100 person-years (aHR 1.06, 95 % CI 0.93–1.21). The adjusted rate ratio (aRR) for recurrent hospitalizations for asthma exacerbations was 1.27 (95 % CI 0.98–1.66), and 1.11 (95 % CI 0.94–1.31) for recurrent asthma-related ED exacerbations.

Conclusions

This study did not observe meaningful differences in acute care utilization for asthma exacerbations among children whose biological mothers had schizophrenia.

背景和假设：虽然母亲精神分裂症与儿童慢性疾病有关，但对母亲患有精神分裂症的儿童急性哮喘发作的风险知之甚少。这项基于人群的研究使用了加拿大安大略省所有地区的健康数据，以评估患有精神分裂症的母亲是否与哮喘发作风险增加有关。研究设计：研究队列包括385,989名从2岁起被诊断为哮喘的儿童，从他们的哮喘诊断时间到最多19岁。将生母在哮喘诊断前被诊断为精神分裂症的儿童（n = 1407）与生母未被诊断为精神分裂症的儿童（n = 384,582）进行比较。研究结果是哮喘相关的住院治疗，以及单独的哮喘相关急诊科（ED）就诊，每次最多可达19岁的儿童。采用Cox比例风险模型评估首次加重，采用经协变量调整后的Andersen-Gill回归评估复发加重。研究结果：有和没有母亲精神分裂症的儿童中，有76人（每1000人年6.9人）首次因哮喘发作住院，有19679人（每1000人年5.4人）（校正风险比[aHR] 1.21, 95% CI 0.97-1.51）。首次哮喘相关ED加重的发生率为25.1比20.7 / 100人年（aHR 1.06, 95% CI 0.93-1.21）。哮喘加重复发住院的调整率比（aRR）为1.27 (95% CI 0.98-1.66)，哮喘相关ED加重复发住院的调整率比为1.11 （95% CI 0.94-1.31）。结论：本研究未观察到生母患有精神分裂症的儿童对哮喘加重的急性护理利用有意义的差异。

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引用次数: 0

Does shame mediate the influence of trauma on psychosis? A systematic review and meta-analytic structural equation modelling approach 羞耻感是否介导了创伤对精神病的影响？系统回顾和元分析结构方程建模方法。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.008

Kimberley Davies , Julia M. Lappin , Nancy Briggs , Sophie Isobel , Zachary Steel

Background

Meta-analytic evidence has linked shame separately to both potentially traumatic events (PTEs) and psychosis, but the influence of shame on the relationship between PTEs and psychosis has not yet been examined. This study used meta-analytic structural equation modelling (MASEM) to examine whether shame plays a mediatory role between PTEs and experiences of psychosis.

Methods

A nested search was conducted within a previous systematic review on psychosis and shame to identify articles that contained a measure of PTEs. Included studies reported a quantitative association between psychosis and shame, and additionally a quantitative relationship between either i) PTEs and psychosis; or ii) PTEs and shame.

Findings

Of the 40 articles initially included, 14 met criteria and 13 were included in the analyses. Overall, shame partially mediated the relationship between PTE's and psychosis, observed through a significant indirect effect (β = 0.15, 95 % CI: 0.11–0.19) and a reduction in the direct path that remained significant (β = 0.13, 95 % CI: 0.06–0.20). Indirect paths through shame between childhood PTEs and psychosis (β = 0.07, 95 % CI: 0.03–0.11), and between lifespan PTEs and psychosis (β = 0.09, 95 % CI: 0.03–0.11), were both small but significant. Both direct paths remained significant, suggesting that shame acts a partial mediator for both types of PTE.

Conclusions

Shame is one path through which potentially traumatic events may influence the experience of psychosis and should be considered alongside other affective types in future modelling of psychosis. Qualitative research may aid further understanding of the mechanisms by which shame operates in this relationship.

背景：荟萃分析证据已将羞耻感分别与潜在创伤性事件（pte）和精神病联系起来，但羞耻感对pte和精神病之间关系的影响尚未得到检验。本研究采用元分析结构方程模型（MASEM）来检验羞耻是否在pte与精神病经历之间起中介作用。方法：在先前关于精神病和羞耻感的系统综述中进行嵌套搜索，以确定包含pte测量的文章。纳入的研究报告了精神病和羞耻感之间的定量关联，以及i) pte和精神病之间的定量关系；或ii) pte和耻辱。结果：在最初纳入的40篇文章中，14篇符合标准，13篇纳入分析。总的来说，羞耻感部分介导了PTE和精神病之间的关系，通过显著的间接效应（β = 0.15, 95% CI: 0.11-0.19）和直接途径的减少（β = 0.13, 95% CI: 0.06-0.20）观察到。童年pte与精神病之间（β = 0.07, 95% CI: 0.03-0.11），以及终身pte与精神病之间（β = 0.09, 95% CI: 0.03-0.11）的间接途径虽小，但均具有显著性。结论：羞耻是潜在的创伤性事件可能影响精神病经历的一条途径，在未来的精神病建模中，羞耻应该与其他情感类型一起考虑。定性研究可能有助于进一步理解羞耻感在这种关系中起作用的机制。

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引用次数: 0

The long-lasting impact of high-intensity training via collaborative care in patients with schizophrenia: A 5-year follow-up study 精神分裂症患者协同护理高强度训练的长期影响：一项5年随访研究。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.012

Mathias Forsberg Brobakken , Mona Nygård , Ismail Cüneyt Güzey , Gunnar Morken , Eivind Wang

Although exercise is medicine for outpatients with schizophrenia, it is unclear if one-year adherence-supported exercise leads to a “tipping point”, at which the exercise becomes a routine manifested as life-long training in the patient group.

Methods

Forty-eight outpatients (28 men/20 women: 35 ± 11 (mean ± SD) years) with schizophrenia (ICD-10: F20–29) were randomised to: 1) collaborative care group (TG), performing aerobic interval (AIT; 4 × 4-min treadmill walking/running at ∼90 % peak heart rate) and leg press maximal strength training (MST; 4 × 4 repetitions at ∼90 % maximal strength [1RM]) 2d·wk.⁻¹ for 1-year, supported by transportation and training supervision; or 2) control group (CG). Peak oxygen uptake (V̇O_2peak) and walking work efficiency were measured directly along with scaled 1RM/power, anthropometry, blood pressure, and blood samples at inclusion, 1-year, and 5-years post-intervention.

Results

The TG increased V̇O_2peak (11 %, p < .01), scaled 1RM (40 %, p < .001), and power (26 %, p < .001) compared to CG after 1-year. At follow-up, no intergroup differences in these factors were observed (all p > .05). Both groups improved walking work efficiency (TG: 11 %; CG: 18 %; both p < .05) after 1-year (no intergroup difference, p > .05), but not at follow-up (both p > .05). At follow-up, HDL (high-density lipoprotein)-cholesterol (−15 %, p < .01) and glucose (26 %, p < .01) decreased/increased(respectively) more in the TG than CG. No other intergroup differences were observed in anthropometry or blood samples.

Conclusion

1-year adherence-supported high-intensity training improves V̇O_2peak, 1RM, and power in outpatients with schizophrenia. However, the improvements in these factors key to longevity are not maintained after 5 years. These findings highlight the importance of long-lasting cost-efficient adherence support, ultimately affecting the population's prognosis.

虽然运动是精神分裂症门诊患者的良药，但尚不清楚一年的坚持支持运动是否会导致“临界点”，即运动成为患者群体的日常表现为终身训练。方法：48例精神分裂症（ICD-10: F20-29）门诊患者（男28例/女20例：35±11（平均±SD）岁）随机分为：1)协同护理组（TG），进行有氧间歇(AIT；4 × 4分钟跑步机步行/跑步在约90%的峰值心率)和腿压最大力量训练(MST；4 × 4次重复，约90%最大力量[1RM]) 2d·周。-1人1年，交通、培训监督支持；2)对照组（CG）。直接测量峰值摄氧量（vo2峰值）和步行工作效率，同时测量纳入研究时、干预后1年和5年的1RM/功率、人体测量、血压和血液样本。结果：TG使vo_2峰值升高（11%,p . 0.05）。两组均提高了步行工作效率(TG: 11%；Cg: 18%；均p < 0.05)，但随访时没有（p < 0.05）。随访时，HDL（高密度脂蛋白）-胆固醇（- 15%,p）。结论：1年坚持支持的高强度训练可改善门诊精神分裂症患者的V / o2峰值、1RM和功率。然而，这些对长寿至关重要的因素的改善并不能在5年后保持下去。这些发现强调了长期经济有效的依从性支持的重要性，最终影响了人群的预后。

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引用次数: 0

Insight and suicidality in first-episode psychosis: The mediating role of depression 首发精神病患者的洞察力与自杀：抑郁的中介作用。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.013

Sümeyra N. Tayfur , Zhiqian Song , Fangyong Li , Hadar Hazan , Toni Gibbs-Dean , Deepa Purushothaman , Sneha Karmani , Javier Ponce Terashima , Cenk Tek , Vinod H. Srihari

Understanding the relationship between insight, depression, and suicidality in first-episode psychosis (FEP) is crucial for improving clinical outcomes and preventing suicide during early treatment stages. This longitudinal cohort study examined 264 participants enrolled in coordinated specialty care (CSC) services for FEP to investigate how insight and depression at admission impact suicidality at 6 and 12 months, assess the mediating role of depression at admission between insight and suicidality, and evaluate the persistence of depression over time. Regression analyses assessed the relationships among these variables, while mediation analyses explored the mediating effect of depression at admission. Significant predictors of suicidality at 6 months were insight (OR 0.71, 95 % CI: 0.53–0.94), depression (OR 5.40, 95 % CI: 2.45–12.61), and previous suicide attempts (OR 2.91, 95 % CI: 1.21–7.00). At 12 months, insight (OR 0.70, 95 % CI: 0.52–0.92) and depression (OR 2.82, 95 % CI: 1.26–6.50) remained significant. Depression at admission mediated 27.32 % of the effect of insight on suicidality at 6 months and 19.76 % at 12 months. Despite a general decrease in depression, a subset of participants remained persistently depressed. The study highlights the significant mediating role of depression at admission in the relationship between insight and suicidality, identifying it as the strongest predictor of suicidality. Early detection and treatment of depression in FEP should be prioritized, and further research should focus on targeted interventions within CSC.

了解首发精神病（FEP）的洞察力、抑郁和自杀之间的关系对于改善临床结果和在早期治疗阶段预防自杀至关重要。本纵向队列研究调查了264名参加FEP协调专科护理（CSC）服务的参与者，以调查入院时的洞察力和抑郁如何影响6个月和12个月的自杀行为，评估入院时抑郁在洞察力和自杀行为之间的中介作用，并评估抑郁随时间的持续性。回归分析评估了这些变量之间的关系，而中介分析探讨了入院时抑郁的中介作用。6个月时自杀的显著预测因子为洞察力（OR 0.71, 95% CI: 0.53-0.94）、抑郁（OR 5.40, 95% CI: 2.45-12.61）和既往自杀企图（OR 2.91, 95% CI: 1.21-7.00）。在12个月时，洞察力（OR 0.70, 95% CI: 0.52-0.92）和抑郁（OR 2.82, 95% CI: 1.26-6.50）仍然显著。入院时抑郁介导了洞察力对6个月和12个月自杀率的影响，分别占27.32%和19.76%。尽管抑郁症总体上有所减少，但仍有一部分参与者持续抑郁。该研究强调了入院时抑郁在洞察力与自杀行为之间的关系中的重要中介作用，确定其为自杀行为的最强预测因子。应优先考虑FEP患者抑郁症的早期发现和治疗，并进一步研究CSC内的针对性干预措施。

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引用次数: 0

Schizotypal dimensions by migrant status in the general population: An exploratory study 一般人群中移民身份的分裂型维度：一项探索性研究。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2025-01-01 DOI: 10.1016/j.schres.2024.12.014

Franck Schürhoff , Baptiste Pignon , Mohamed Lajnef , Grégoire Baudin , Jean-Romain Richard , Hélène Charreire , Andrea Tortelli , Andrei Szöke

Migrant status and ethnic minority background have been associated with increased risk for psychosis. However, it remains unclear if such association exists with subclinical forms of psychosis. In two general population samples, totaling 460 subjects, we investigated whether migrant status and/or ethnicity predict self-reported positive, negative and/or disorganized dimensions of psychosis (as measured by the SPQ-B). In comparison to the reference population, we observed higher scores in the negative dimension among both first and second-generation migrants as well as in some ethnic minority groups (particularly North Africa and French overseas). Our findings highlight the need to understand the mechanisms underlying this association between negative schizotypal traits and migrant/ethnic minority status. The fact that migration/ethnicity are associated with both psychotic disorders and subclinical manifestations of psychosis also support the psychosis continuum theory. The higher rates of negative schizotypal traits in these populations underscores the necessity for tailored policies and interventions to enhance mental health and prevent the transition to psychosis in these subgroups.

移民身份和少数民族背景与精神病风险增加有关。然而，尚不清楚这种关联是否存在于亚临床形式的精神病。在两个普通人群样本中，总共460名受试者，我们调查了移民身份和/或种族是否能预测自我报告的精神病阳性、阴性和/或紊乱维度（由SPQ-B测量）。与参考人群相比，我们观察到第一代和第二代移民以及一些少数民族群体（特别是北非和海外法国人）在消极方面的得分更高。我们的研究结果强调了理解消极分裂型特征与移民/少数民族身份之间联系的机制的必要性。移民/种族与精神病和精神病的亚临床表现相关的事实也支持精神病连续体理论。在这些人群中，负性分裂型特征的比例较高，这强调了有必要制定有针对性的政策和干预措施，以增强这些亚群体的心理健康，并防止过渡到精神病。

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