Schizophrenia Research最新文献_第5页

Muscarinic deficits - part of a cholinergic-dopaminergic- glutamatergic imbalance in schizophrenia? 肌卡因缺陷--精神分裂症中胆碱能-多巴胺能-谷氨酸能失衡的一部分？

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.11.001

Matcheri S. Keshavan , Pegah Seif , Rajiv Tandon

引用次数: 0

Problematic gambling and psychotic-like experiences: Findings from Japan 问题赌博和类似精神病的经历：日本的研究结果。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.11.003

Andrew Stickley , Aya Shirama , Risa Yamada , Tomiki Sumiyoshi

Background

Comparatively little is known about the association between problematic gambling and psychotic-like experiences (PLEs). This study examined the association among adults in the Japanese general population and whether this association differs between men and women.

Methods

Data were analyzed from 3701 individuals that were obtained in an online survey. Information on problematic gambling was assessed with the Japanese short version of the South Oaks Gambling Screen Revised (SOGS-R), while PLEs were measured with the PRIME Screen-Revised (PS-R). Logistic regression was used to examine associations.

Results

In an analysis adjusted for sociodemographic, self-rated health and mental health variables, problematic gambling was associated with significantly higher odds for PLEs (OR: 1.64, 95%CI: 1.07–2.50). When the analysis was stratified by sex, problematic gambling was significantly associated with PLEs in women (OR: 2.80, 95%CI: 1.33–5.89) but not men (OR: 1.32, 95%CI: 0.78–2.22) in the fully adjusted model. No effect modification by sex was found.

Conclusion

Problematic gambling is associated with higher odds for PLEs among adults in Japan. More research is now needed to determine which factors are associated with the co-occurrence of problematic gambling and PLEs and whether this comorbidity is associated with a higher risk for negative gambling-related and other outcomes.

背景：人们对问题赌博与精神病样经历（PLEs）之间的关系知之甚少。本研究调查了日本普通人群中成年人的相关性，以及这种相关性在男性和女性之间是否存在差异：方法：分析了通过在线调查获得的 3701 人的数据。有关问题赌博的信息通过南橡树赌博筛查修订版（South Oaks Gambling Screen Revised，SOGS-R）日语简版进行评估，而 PLEs 则通过 PRIME 筛查修订版（PRIME Screen-Revised，PS-R）进行测量。采用逻辑回归法研究两者之间的关联：在对社会人口学、自评健康和心理健康变量进行调整后的分析中，问题赌博与 PLEs 的几率明显较高相关（OR：1.64，95%CI：1.07-2.50）。当按性别进行分层分析时，在完全调整模型中，女性（OR：2.80，95%CI：1.33-5.89）而男性（OR：1.32，95%CI：0.78-2.22）的问题性赌博与 PLEs 显著相关。结论：问题性赌博与较高的患病几率有关：结论：问题赌博与日本成年人患 PLE 的几率较高有关。现在需要进行更多的研究，以确定哪些因素与问题性赌博和 PLEs 同时发生有关，以及这种并发症是否与赌博相关的负面结果和其他结果的更高风险有关。

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引用次数: 0

Orientation-dependent contextual modulation of contrast in schizophrenia 精神分裂症患者对比度的方向依赖性情境调节

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-09 DOI: 10.1016/j.schres.2024.10.021

Victor J. Pokorny , Scott R. Sponheim , Cheryl A. Olman

Introduction

Schizophrenia is associated with weakened contextual modulation of visual contrast perception, which is generally predicted by population average neural firing rates in primary visual cortex (V1). We use high field fMRI and a novel task to assess V1-instrinsic and V1-extrinsic mechanisms of atypical contextual modulation in schizophrenia.

Methods

We examined the BOLD responses of individuals with schizophrenia (SCZ = 34), bipolar disorder (BP = 25), unaffected first-degree relatives of SCZ (SREL = 20), unaffected first-degree relatives of BP (BPREL = 13) and healthy controls (CON = 23). Participants were presented with near- and far-surrounds oriented at 20° and 70° relative to center gratings.

Results

We observed orientation-dependent modulation of V1 BOLD activation to near-surrounds across groups. In particular, the SCZ and CON groups showed significant orientation-dependent contextual modulation (Cohen's d_z SCZ = 0.56; CON = 0.63). Surprisingly, the direction of the modulation was opposite of predicted: greater BOLD activation for the condition that was expected to produce suppression.

Conclusions

Our results differ from previous reports: we observed successful orientation-dependent modulation of V1 activation in SCZ. Furthermore, our results suggest that spatial attention and figure-ground modulation may play an important role in determining the direction and magnitude of orientation-dependent modulation.

简介精神分裂症与视觉对比感知的情境调节减弱有关，这通常是由初级视觉皮层（V1）的群体平均神经发射率预测的。我们使用高场fMRI和一项新任务来评估精神分裂症患者非典型语境调制的V1内在和V1外在机制：我们研究了精神分裂症患者（SCZ = 34）、双相情感障碍患者（BP = 25）、SCZ 患者未受影响的一级亲属（SREL = 20）、BP 患者未受影响的一级亲属（BPREL = 13）和健康对照组（CON = 23）的 BOLD 反应。研究人员向参与者展示了相对于中心光栅20°和70°的近圆和远圆：结果：我们观察到各组V1 BOLD激活对近圆环的定向调节。特别是，SCZ组和CON组显示出显著的方位依赖性情境调节（Cohen's dz SCZ = 0.56; CON = 0.63）。令人惊讶的是，调制的方向与预测相反：在预期会产生抑制的条件下，BOLD激活更强：我们的研究结果与之前的报告不同：我们观察到，在 SCZ 中，V1 激活成功地受到了方向依赖性调节。此外，我们的研究结果表明，空间注意力和图形-地面调制可能在决定方位依赖性调制的方向和幅度方面起着重要作用。

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引用次数: 0

Self-disturbance in schizophrenia: Updating the research and bridging the gaps 精神分裂症的自我干扰：更新研究，缩小差距。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-08 DOI: 10.1016/j.schres.2024.10.017

Amy M. Jimenez, Michael F. Green

引用次数: 0

The theoretical sensitivity of virtual assessment of catatonia 紧张症虚拟评估的理论敏感性。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-08 DOI: 10.1016/j.schres.2024.10.020

James Luccarelli , Joshua Ryan Smith , Stephan Heckers , Gregory Fricchione , Jo Ellen Wilson

引用次数: 0

Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients 血浆 NGAL（而非 IFN-γ）可预测药物治疗无效的中国汉族精神分裂症患者的早期治疗反应。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-07 DOI: 10.1016/j.schres.2024.10.025

Xiaoxiao Sun , Meijuan Li , Yuying Qiu , Qiao Su, Jiayue Wang, Fuyou Bi, Jie Li

Background

Early prediction of treatment efficacy can assist psychiatrists in optimizing personalized treatment strategies for drug-naïve schizophrenia patients. This study aimed to explore the predictive value of plasma concentrations of Interferon-γ (IFN-γ) and Neutrophil gelatinase-associated lipocalin (NGAL) in early treatment responses.

Methods

We conducted a longitudinal study involving 125 drug-naïve schizophrenia patients and 75 healthy controls. Plasma samples were collected and analyzed at baseline and after 8 weeks of treatment. Based on treatment outcomes, patients were classified as Responders (R, n = 84) or Non-responders (NR, n = 41).

Results

At baseline, schizophrenia patients showed significantly lower IFN-γ and NGAL concentrations compared to healthy controls. NGAL levels were notably lower in the NR group compared to the R group. After treatment, both IFN-γ and NGAL concentrations increased in all patients, with a marked rise in IFN-γ levels. NGAL concentration negatively correlated with the positive factor at baseline, adjusting for confounders such as age, BMI, smoking, and duration of untreated illness. Logistic regression analysis identified lower baseline NGAL concentrations as a predictor of poor early treatment response.

Conclusion

Pre-treatment plasma NGAL concentrations may serve as a potential biomarker for predicting early treatment response in drug-naïve Chinese Han schizophrenia patients. These findings highlight NGAL as a possible target for future therapeutic development in schizophrenia.

背景：早期预测疗效有助于精神科医生优化对药物治疗无效的精神分裂症患者的个性化治疗策略。本研究旨在探讨干扰素-γ（IFN-γ）和中性粒细胞明胶酶相关脂质体（NGAL）的血浆浓度在早期治疗反应中的预测价值：我们进行了一项纵向研究，涉及 125 名药物治疗前精神分裂症患者和 75 名健康对照者。在基线期和治疗 8 周后收集血浆样本并进行分析。根据治疗结果，患者被分为应答者（R，n = 84）或无应答者（NR，n = 41）：基线时，精神分裂症患者的 IFN-γ 和 NGAL 浓度明显低于健康对照组。NR 组的 NGAL 水平明显低于 R 组。治疗后，所有患者的IFN-γ和NGAL浓度都有所增加，其中IFN-γ浓度明显升高。在对年龄、体重指数、吸烟和未治疗病程等混杂因素进行调整后，NGAL浓度与基线阳性因子呈负相关。逻辑回归分析表明，较低的基线NGAL浓度可预测较差的早期治疗反应：结论：治疗前血浆NGAL浓度可作为一种潜在的生物标志物，用于预测药物治疗无效的中国汉族精神分裂症患者的早期治疗反应。结论：治疗前血浆NGAL浓度可作为潜在的生物标志物，用于预测药物治疗无效的中国汉族精神分裂症患者的早期治疗反应。这些发现强调了NGAL可能是未来精神分裂症治疗开发的一个靶点。

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引用次数: 0

Sex versus gender associations with depressive symptom trajectories over 24 months in first-episode schizophrenia spectrum disorders 首次发病的精神分裂症谱系障碍患者在 24 个月内的抑郁症状轨迹与性别的关系。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-07 DOI: 10.1016/j.schres.2024.10.022

H.K. Luckhoff , E.C. del Re , R. Smit , S. Kilian , L. Phahladira , R. Emsley , L. Asmal

Background

Females with schizophrenia often experience more severe and persistent depressive symptoms than males, in particular during the acute phase of the illness. In contrast to sex (a biological distinction), little is known about the associations between gender (a societal construct) and depression in schizophrenia.

Aim

We examined the associations of sex versus gender with visit-wise changes in depressive symptoms over 24 months in patients with first-episode schizophrenia spectrum disorders (FES) (n = 77) compared to matched healthy controls (n = 64).

Methods

The Bem Sex Role Inventory was used to measure feminine gender role endorsement. The Calgary Depression Scale for Schizophrenia was used to measure depressive symptoms at baseline, weeks 2, 4, and 6, and months 3, 6, 9, 12, 15, 18, 21, and 24. We used mixed models for continuous repeated measures to examine the moderating effects of childhood trauma, premorbid adjustment, age of psychosis onset, and cannabis use on the associations of sex and gender with depressive symptoms.

Results

Higher feminine gender role endorsement, independent of biological sex, was associated with more severe baseline depression and worse initial treatment trajectories. Childhood trauma exposure was also associated with worse depression outcomes, and mediated the association between gender and pre-treatment depression severities.

Conclusions

Gender, but not sex, was associated with depressive symptom trajectories in FES. The consideration of both sex and gender offered a more nuanced insight into depressive symptoms compared to biological sex alone.

背景：女性精神分裂症患者的抑郁症状往往比男性患者更严重、更持久，尤其是在疾病的急性期。目的：我们研究了首次发作精神分裂症谱系障碍（FES）患者（n = 77）与相匹配的健康对照组（n = 64）在24个月内就诊时抑郁症状变化的性别关联：方法：使用贝姆性别角色量表来测量女性性别角色认同。卡尔加里精神分裂症抑郁量表用于测量基线、第 2 周、第 4 周和第 6 周以及第 3 个月、第 6 个月、第 9 个月、第 12 个月、第 15 个月、第 18 个月、第 21 个月和第 24 个月的抑郁症状。我们使用连续重复测量的混合模型来研究童年创伤、病前适应、精神病发病年龄和大麻使用对性别与抑郁症状关联的调节作用：结果：与生理性别无关，女性性别角色认可度越高，基线抑郁越严重，初始治疗效果越差。童年时期遭受的创伤也与抑郁症的恶化有关，并在性别与治疗前抑郁症严重程度之间起中介作用：结论：性别与 FES 的抑郁症状轨迹有关，但与性别无关。与仅考虑生理性别相比，同时考虑性别和生理性别能更细致地了解抑郁症状。

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引用次数: 0

Meta-analysis of the factor structure of the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS) 消极症状评估量表（SANS）和积极症状评估量表（SAPS）因子结构的元分析。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-07 DOI: 10.1016/j.schres.2024.10.027

Federico Dazzi , Alan Shafer

Introduction

The SAPS and SANS was designed to measure two broad factors, but the majority of factor analyses conducted have found substantially more dimensions. To investigate their structure a meta-analysis was conducted of SAPS and SANS factor analysis.

Method

A total of 42 articles reporting 55 factor analyses were retrieved from database searches (PubMed, PsychINFO) supplemented by searches of references. Reproduced correlations were calculated from retrieved factor analyses and 3 separate meta-analyses were conducted.

Results

The meta-analysis of the SAPS SANS global ratings (k = 34; n = 5219) yielded a 3-factor solution including Positive Symptoms (Hallucinations and Delusions), Negative Symptoms (Affective Flattening, Alogia, Avolition/Apathy, Anhedonia/Asociality and Attentional Impairment), and Disorganization (Positive Formal Thought Disorder and Bizarre Behavior). The item analysis of the SAPS SANS combined (k = 11; n = 3146) found 4 factors, with the Negative Symptoms splitting into Affective Flattening/Alogia and Avolition/Asociality as main difference. The SANS only item analysis (k = 10; n = 2073) identified 3 factors, Affective Flattening, Avolition/Asociality, and Alogia/Inattentiveness. Importantly, our data suggests that the items Inappropriate Affect and Poverty of Content of Speech should be moved from Negative Symptoms to the Disorganization factor. Attentional Impairment shows the highest loading on Negative Symptoms but its inclusion under this dimension is conceptually unclear and it may be better considered as a non-specific domain.

Conclusions

The three factor structure of Positive Symptoms, Negative Symptoms and Disorganization accounted for most of the data. The SAPS SANS global scales are generally valid, but suggestions for a conservative revision of SAPS SANS structure, including supplementary subscales, are presented.

介绍：SAPS 和 SANS 的设计目的是测量两个广泛的因子，但所进行的大多数因子分析都发现了更多的维度。为了研究它们的结构，我们对 SAPS 和 SANS 因子分析进行了元分析：方法：通过数据库搜索（PubMed、PsychINFO）和参考文献搜索，共检索到 42 篇报道 55 项因子分析的文章。从检索到的因子分析中计算出再现相关性，并分别进行了 3 次元分析：对 SAPS SANS 整体评分的荟萃分析（k = 34；n = 5219）得出了一个 3 因子解决方案，包括阳性症状（幻觉和妄想）、阴性症状（情感平淡、嗜睡、逃避/情感淡漠、失乐症/社交障碍和注意力障碍）和组织混乱（阳性形式思维障碍和怪异行为）。SAPS SANS 合并项目分析（k=11；n=3146）发现了 4 个因子，其中消极症状分为情感平淡/自闭和逃避/社交，这是主要差异。仅对 SANS 进行的项目分析（k = 10；n = 2073）发现了 3 个因子，即情感扁平化、逃避/社交性和焦虑/注意力不集中。重要的是，我们的数据表明，"不恰当情感 "和 "言语内容贫乏 "这两个项目应从 "消极症状 "移至 "组织混乱 "因子。注意力障碍在消极症状中的负荷最高，但将其纳入这一维度在概念上并不清晰，最好将其视为一个非特异性领域：积极症状、消极症状和组织混乱的三因子结构涵盖了大部分数据。SAPS SANS总体量表总体有效，但建议对SAPS SANS结构进行保守修订，包括补充子量表。

{"title":"Meta-analysis of the factor structure of the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS)","authors":"Federico Dazzi , Alan Shafer","doi":"10.1016/j.schres.2024.10.027","DOIUrl":"10.1016/j.schres.2024.10.027","url":null,"abstract":"<div><h3>Introduction</h3><div>The SAPS and SANS was designed to measure two broad factors, but the majority of factor analyses conducted have found substantially more dimensions. To investigate their structure a meta-analysis was conducted of SAPS and SANS factor analysis.</div></div><div><h3>Method</h3><div>A total of 42 articles reporting 55 factor analyses were retrieved from database searches (PubMed, PsychINFO) supplemented by searches of references. Reproduced correlations were calculated from retrieved factor analyses and 3 separate meta-analyses were conducted.</div></div><div><h3>Results</h3><div>The meta-analysis of the SAPS SANS global ratings (k = 34; <em>n</em> = 5219) yielded a 3-factor solution including Positive Symptoms (Hallucinations and Delusions), Negative Symptoms (Affective Flattening, Alogia, Avolition/Apathy, Anhedonia/Asociality and Attentional Impairment), and Disorganization (Positive Formal Thought Disorder and Bizarre Behavior). The item analysis of the SAPS SANS combined (k = 11; <em>n</em> = 3146) found 4 factors, with the Negative Symptoms splitting into Affective Flattening/Alogia and Avolition/Asociality as main difference. The SANS only item analysis (k = 10; <em>n</em> = 2073) identified 3 factors, Affective Flattening, Avolition/Asociality, and Alogia/Inattentiveness. Importantly, our data suggests that the items Inappropriate Affect and Poverty of Content of Speech should be moved from Negative Symptoms to the Disorganization factor. Attentional Impairment shows the highest loading on Negative Symptoms but its inclusion under this dimension is conceptually unclear and it may be better considered as a non-specific domain.</div></div><div><h3>Conclusions</h3><div>The three factor structure of Positive Symptoms, Negative Symptoms and Disorganization accounted for most of the data. The SAPS SANS global scales are generally valid, but suggestions for a conservative revision of SAPS SANS structure, including supplementary subscales, are presented.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 464-472"},"PeriodicalIF":3.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives 早期精神病和一级亲属的睡眠振荡及其与依赖睡眠的记忆巩固的关系。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-07 DOI: 10.1016/j.schres.2024.10.026

Dan Denis , Bengi Baran , Dimitrios Mylonas , Courtney Spitzer , Nicolas Raymond , Christine Talbot , Erin Kohnke , Olivia Larson , Robert Stickgold , Matcheri Keshavan , Dara S. Manoach

Sleep spindles mediate sleep-dependent memory consolidation, particularly when coupled to neocortical slow oscillations (SOs). Schizophrenia is characterized by a deficit in sleep spindles that correlates with reduced overnight memory consolidation. Here, we examined sleep spindle activity, SO-spindle coupling, and both motor procedural and verbal declarative memory consolidation in early course, minimally medicated psychosis patients and non-psychotic first-degree relatives. Using a four-night experimental procedure, we observed significant deficits in spindle density and amplitude in patients relative to controls that were driven by individuals with schizophrenia. Schizophrenia patients also showed reduced sleep-dependent consolidation of motor procedural memory, which correlated with lower spindle density. Contrary to expectations, there were no group differences in the consolidation of declarative memory on a word pairs task. Nor did the relatives of patients differ in spindle activity or memory consolidation compared with controls, however increased consistency in the timing of SO-spindle coupling were seen in both patients and relatives. Our results extend prior work by demonstrating correlated deficits in sleep spindles and sleep-dependent motor procedural memory consolidation in early course, minimally medicated patients with schizophrenia, but not in first-degree relatives. This is consistent with other work in suggesting that impaired sleep-dependent memory consolidation has some specificity for schizophrenia and is a core feature rather than reflecting the effects of medication or chronicity.

睡眠棘介导依赖睡眠的记忆巩固，尤其是与新皮质慢振荡（SOs）结合时。精神分裂症的特征是睡眠纺锤体的缺失，而睡眠纺锤体的缺失与隔夜记忆巩固的减少有关。在这里，我们研究了病程早期、用药最少的精神病患者和非精神病患者一级亲属的睡眠主轴活动、SO-主轴耦合以及运动程序性记忆和言语陈述性记忆的巩固。通过四晚的实验过程，我们观察到相对于对照组，精神分裂症患者的纺锤体密度和振幅明显不足。精神分裂症患者还表现出依赖睡眠的运动程序记忆巩固能力下降，这与纺锤体密度较低有关。与预期相反的是，在单词配对任务中，陈述性记忆的巩固并无群体差异。与对照组相比，患者亲属在纺锤体活动或记忆巩固方面也没有差异，但在患者和亲属中，SO-纺锤体耦合的时间一致性都有所提高。我们的研究结果扩展了之前的研究，证明了早期精神分裂症患者在睡眠纺锤体和依赖睡眠的运动程序记忆巩固方面存在相关缺陷，而一级亲属中却没有这种缺陷。这与其他研究结果一致，表明依赖睡眠的记忆巩固功能受损对精神分裂症有一定的特异性，是精神分裂症的核心特征，而不是反映药物或慢性病的影响。

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引用次数: 0

Validation of the Amharic version of Cognitive Assessment Interview (CAI-A) in people with schizophrenia in Ethiopia 在埃塞俄比亚精神分裂症患者中验证阿姆哈拉语版认知评估访谈（CAI-A）

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-06 DOI: 10.1016/j.schres.2024.10.019

Yohannes Gebreegziabhere , Kassahun Habatmu , Matteo Cella , Atalay Alem

Assessing cognition with interview-based measures could be a low-resource alternative to traditional cognitive tests. We previously adapted the Cognitive Assessment Interview (CAI) into Amharic (CAI-A) for use with people with schizophrenia (PWS) in Ethiopia. This study examined the convergent and structural validity of the CAI-A in a group of 350 PWS sub-sampled from the Neuropsychiatric Genetics of African Populations – Psychosis (NeuroGAP-Psychosis) study, who fulfilled the inclusion criteria. Data were analyzed using confirmatory factor analysis (CFA), Spearman's correlation coefficient (ρ), multiple regression, and Item Response Theory (IRT). A one-factor solution best fits the items in the tool (factor loadings between 0.58 and 0.79), suggesting structural validity. The total score of the CAI-A moderately correlated with functioning (ρ = 0.44, p < 0.001) and symptom dimensions (ρ between 0.38 and 0.46, p < 0.001), suggesting convergent validity. Multiple regression showed that age (β = −0.06, 95 % CI (−0.12, 0.00), p = 0.044), the duration of illness (β = 0.08, 95 % CI (0.01, 0.14), p = 0.033), and medication side effects (β = 0.35, 95 % CI (0.21, 0.50), p < 0.001) were positively and significantly associated with the CAI-A total score. The IRT analysis suggested that the tool best functions among participants with moderate to severe impairment (difficulty coefficient between 0.05 and 2.73). We found that the CAI-A is a valid tool for use in Ethiopia. The moderate correlation with symptom and functional measures suggested that self-reported cognitive symptoms parallel other symptom dimensions and functional disability. The CAI-A can be used in clinical practice and research activities in PWS in Ethiopia when subjective assessment of cognition is desired.

以访谈为基础的认知评估方法可以在资源匮乏的情况下替代传统的认知测试。我们曾将认知评估访谈（CAI）改编成阿姆哈拉语（CAI-A），用于埃塞俄比亚的精神分裂症患者（PWS）。本研究从 "非洲人群神经精神遗传学--精神病（NeuroGAP-Psychosis）"研究中抽取了 350 名符合纳入标准的精神分裂症患者，对 CAI-A 的收敛性和结构有效性进行了研究。数据分析采用了确证因子分析（CFA）、斯皮尔曼相关系数（ρ）、多元回归和项目反应理论（IRT）。单因素解最适合工具中的项目（因素负荷在 0.58 和 0.79 之间），表明结构有效。CAI-A 的总分与功能（ρ = 0.44，p <0.001）和症状维度（ρ 在 0.38 和 0.46 之间，p <0.001）呈中度相关，表明具有收敛有效性。多元回归显示，年龄（β = -0.06，95 % CI (-0.12, 0.00)，p = 0.044）、病程（β = 0.08，95 % CI (0.01, 0.14)，p = 0.033）和药物副作用（β = 0.35，95 % CI (0.21, 0.50)，p <0.001）与 CAI-A 总分呈显著正相关。IRT 分析表明，该工具在患有中度至重度障碍的参与者中功能最佳（难度系数介于 0.05 和 2.73 之间）。我们发现，CAI-A 是一种适用于埃塞俄比亚的有效工具。与症状和功能测量的适度相关性表明，自我报告的认知症状与其他症状维度和功能障碍平行。当需要对认知能力进行主观评估时，CAI-A 可用于埃塞俄比亚 PWS 的临床实践和研究活动。

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引用次数: 0