Schizophrenia Research最新文献_第10页

Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling 通过 CRISPR 基因组编辑和基于体外疾病模型的诱导多能干细胞，探究精神分裂症患者体内 ZMYND11 基因突变的生物学后果

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2024.01.024

Csongor Tordai , Edit Hathy , Hella Gyergyák , Katalin Vincze , Máté Baradits , Júlia Koller , Ádám Póti , Bálint Jezsó , László Homolya , Mária Judit Molnár , László Nagy , Dávid Szüts , Ágota Apáti , János M. Réthelyi

Background

Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly understood etiology, associated with both genetic and environmental factors. De novo mutations (DNMs) represent a new source of genetic variation in SCZ, however, in most cases their biological significance remains unclear. We sought to investigate molecular disease pathways connected to DNMs in SCZ by combining human induced pluripotent stem cell (hiPSC) based disease modeling and CRISPR-based genome editing.

Methods

We selected a SCZ case-parent trio with the case individual carrying a potentially disease causing 1495C > T nonsense DNM in the zinc finger MYND domain-containing protein 11 (ZMYND11), a gene implicated in biological processes relevant for SCZ. In the patient-derived hiPSC line the mutation was corrected using CRISPR, while monoallelic or biallelic frameshift mutations were introduced into a control hiPSC line. Isogenic cell lines were differentiated into hippocampal neuronal progenitor cells (NPCs) and functionally active dentate gyrus granule cells (DGGCs). Immunofluorescence microscopy and RNA sequencing were used to test for morphological and transcriptomic differences at NPC and DGCC stages. Functionality of neurons was investigated using calcium-imaging and multi-electrode array measurements.

Results

Morphology in the mutant hippocampal NPCs and neurons was preserved, however, we detected significant transcriptomic and functional alterations. RNA sequencing showed massive upregulation of neuronal differentiation genes, and downregulation of cell adhesion genes. Decreased reactivity to glutamate was demonstrated by calcium-imaging.

Conclusions

Our findings lend support to the involvement of glutamatergic dysregulation in the pathogenesis of SCZ. This approach represents a powerful model system for precision psychiatry and pharmacological research.

背景精神分裂症（SCZ）是一种严重的神经精神疾病，其病因复杂且不甚明了，与遗传和环境因素都有关系。新发突变（DNMs）是精神分裂症遗传变异的新来源，但在大多数情况下，其生物学意义仍不清楚。我们试图通过结合基于疾病建模的人类诱导多能干细胞（hiPSC）和基于CRISPR的基因组编辑，研究与SCZ中DNMs相关的分子疾病通路。方法我们选择了一个SCZ病例-父母三人组，病例个体携带锌指MYND结构域含蛋白11（ZMYND11）中可能致病的1495C >T无义DNM，该基因与SCZ相关的生物过程有牵连。在患者来源的 hiPSC 株系中，使用 CRISPR 对突变进行了校正，同时在对照 hiPSC 株系中引入了单拷贝或双拷贝移帧突变。同源细胞系被分化成海马神经元祖细胞（NPC）和功能活跃的齿状回颗粒细胞（DGGC）。免疫荧光显微镜和 RNA 测序用于检测 NPC 和 DGCC 阶段的形态学和转录组差异。结果突变体海马 NPCs 和神经元的形态保持不变，但我们检测到了显著的转录组和功能改变。RNA 测序显示神经元分化基因大量上调，细胞粘附基因下调。结论我们的研究结果支持谷氨酸能失调参与 SCZ 的发病机制。这种方法为精准精神病学和药理学研究提供了一个强大的模型系统。

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引用次数: 0

Mitochondrial dysfunction in psychiatric disorders 精神疾病中的线粒体功能障碍。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2022.08.027

Peiyan Ni , Yao Ma , Sangmi Chung

Psychiatric disorders are a heterogeneous group of mental disorders with abnormal mental or behavioral patterns, which severely distress or disable affected individuals and can have a grave socioeconomic burden. Growing evidence indicates that mitochondrial function plays an important role in developing psychiatric disorders. This review discusses the neuropsychiatric consequences of mitochondrial abnormalities in both animal models and patients. We also discuss recent studies associated with compromised mitochondrial function in various psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MD), and bipolar disorders (BD). These studies employ various approaches including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cells (iPSCs) studies. We also summarize the evidence from animal models and clinical trials to support mitochondrial function as a potential therapeutic target to treat various psychiatric disorders. This review will contribute to furthering our understanding of the metabolic etiology of various psychiatric disorders, and help guide the development of optimal therapies.

精神障碍是一组具有异常心理或行为模式的异质性精神疾病，严重困扰患者或使其丧失能力，并可能造成严重的社会经济负担。越来越多的证据表明，线粒体功能在精神疾病的发生中扮演着重要角色。本综述将讨论线粒体异常在动物模型和患者中造成的神经精神后果。我们还讨论了与精神分裂症（SCZ）、重度抑郁障碍（MD）和双相情感障碍（BD）等各种精神疾病中线粒体功能受损有关的最新研究。这些研究采用了各种方法，包括尸体研究、成像研究、遗传研究和诱导多能干细胞（iPSCs）研究。我们还总结了动物模型和临床试验的证据，以支持线粒体功能作为治疗各种精神疾病的潜在治疗靶点。这篇综述将有助于我们进一步了解各种精神疾病的代谢病因，并有助于指导开发最佳疗法。

引用次数: 0

Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview 利用基因组学和多能干细胞了解精神分裂症的最新进展：荟萃分析综述。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2022.11.001

Ashwani Choudhary, David Peles, Ritu Nayak, Liron Mizrahi, Shani Stern

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which disables the patients as well as decreases their life expectancy and quality of life. Common and rare variants studies on SCZ subjects have provided >100 genomic loci that hold importance in the context of SCZ pathophysiology. Transcriptomic studies from clinical samples have informed about the differentially expressed genes (DEGs) and non-coding RNAs in SCZ patients. Despite these advancements, no causative genes for SCZ were found and hence SCZ is difficult to recapitulate in animal models. In the last decade, induced Pluripotent Stem Cells (iPSCs)-based models have helped in understanding the neural phenotypes of SCZ by studying patient iPSC-derived 2D neuronal cultures and 3D brain organoids. Here, we have aimed to provide a simplistic overview of the current progress and advancements after synthesizing the enormous literature on SCZ genetics and SCZ iPSC-based models. Although further understanding of SCZ genetics and pathophysiological mechanisms using these technological advancements is required, the recent approaches have allowed to delineate important cellular mechanisms and biological pathways affected in SCZ.

精神分裂症（SCZ）是一种复杂的、可遗传的多基因神经精神疾病，它不仅使患者丧失能力，还降低了他们的预期寿命和生活质量。对 SCZ 患者进行的常见和罕见变异研究提供了超过 100 个基因组位点，这些位点在 SCZ 病理生理学方面具有重要意义。对临床样本进行的转录组学研究则揭示了SCZ患者的差异表达基因（DEGs）和非编码RNAs。尽管取得了这些进展，但仍未找到 SCZ 的致病基因，因此 SCZ 难以在动物模型中再现。在过去十年中，基于诱导多能干细胞（iPSCs）的模型通过研究患者iPSC衍生的二维神经元培养物和三维脑器官组织，帮助人们了解了SCZ的神经表型。在此，我们旨在综合有关 SCZ 遗传学和基于 SCZ iPSC 模型的大量文献后，对当前的进展和进步做一个简单的概述。虽然还需要利用这些技术进步进一步了解 SCZ 遗传学和病理生理学机制，但最近的研究方法已经能够描述 SCZ 重要的细胞机制和生物通路。

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引用次数: 0

Harnessing stem cell-based approaches for clinically meaningful discoveries in schizophrenia 利用基于干细胞的方法，发现对临床有意义的精神分裂症。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2024.08.006

Paulo Lizano , Rakesh Karmacharya

引用次数: 0

Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models 利用人类诱导多能干细胞模型探究精神分裂症的分子和细胞病理机制。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2022.06.028

Rebecca Sebastian , Yoonjae Song , ChangHui Pak

With recent advancements in psychiatric genomics, as a field, “stem cell-based disease modelers” were given the exciting yet daunting task of translating the extensive list of disease-associated risks into biologically and clinically relevant information in order to deliver therapeutically meaningful leads and insights. Despite their limitations, human induced pluripotent stem cell (iPSCs) based models have greatly aided our understanding of the molecular and cellular mechanisms underlying the complex etiology of brain disorders including schizophrenia (SCZ). In this review, we summarize the major findings from studies in the past decade which utilized iPSC models to investigate cell type-specific phenotypes relevant to idiopathic SCZ and disease penetrant alleles. Across cell type differences, several biological themes emerged, serving as potential neurodevelopmental mechanisms of SCZ, including oxidative stress and mitochondrial dysfunction, depletion of progenitor pools and insufficient differentiation potential of these progenitors, and structural and functional deficits of neurons and other supporting cells. Here, we discuss both the recent progress as well as challenges and improvements needed for future studies utilizing iPSCs as a model for SCZ and other neuropsychiatric disorders.

随着精神病基因组学的最新进展，作为一个领域，"基于干细胞的疾病模型 "被赋予了令人兴奋而又艰巨的任务，即把大量与疾病相关的风险转化为生物和临床相关信息，以提供有治疗意义的线索和见解。基于人类诱导多能干细胞（iPSCs）的模型尽管有其局限性，但极大地帮助了我们对包括精神分裂症（SCZ）在内的脑部疾病复杂病因的分子和细胞机制的理解。在这篇综述中，我们总结了过去十年中利用 iPSC 模型研究与特发性 SCZ 和疾病穿透性等位基因相关的细胞类型特异性表型的主要发现。在细胞类型差异方面，出现了几个生物学主题，作为SCZ潜在的神经发育机制，包括氧化应激和线粒体功能障碍、祖细胞池耗竭和这些祖细胞的分化潜能不足，以及神经元和其他支持细胞的结构和功能缺陷。在此，我们将讨论利用 iPSCs 作为 SCZ 和其他神经精神疾病模型的最新进展以及未来研究面临的挑战和需要改进的地方。

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引用次数: 0

Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review 研究精神分裂症突触功能障碍和认知的人类干细胞模型：叙述性综述。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-01 DOI: 10.1016/j.schres.2023.02.029

Stephanie Santarriaga , Kaia Gerlovin , Yasmine Layadi , Rakesh Karmacharya

Cognitive impairment is the strongest predictor of functional outcomes in schizophrenia and is hypothesized to result from synaptic dysfunction. However, targeting synaptic plasticity and cognitive deficits in patients remains a significant clinical challenge. A comprehensive understanding of synaptic plasticity and the molecular basis of learning and memory in a disease context can provide specific targets for the development of novel therapeutics targeting cognitive impairments in schizophrenia. Here, we describe the role of synaptic plasticity in cognition, summarize evidence for synaptic dysfunction in schizophrenia and demonstrate the use of patient derived induced-pluripotent stem cells for studying synaptic plasticity in vitro. Lastly, we discuss current advances and future technologies for bridging basic science research of synaptic dysfunction with clinical and translational research that can be used to predict treatment response and develop novel therapeutics.

认知障碍是精神分裂症功能性结果的最有力预测因素，据推测，认知障碍是突触功能障碍的结果。然而，针对患者的突触可塑性和认知障碍仍然是一项重大的临床挑战。全面了解疾病背景下的突触可塑性以及学习和记忆的分子基础，可以为开发针对精神分裂症认知障碍的新型疗法提供特定靶点。在此，我们描述了突触可塑性在认知中的作用，总结了精神分裂症突触功能障碍的证据，并展示了如何利用患者诱导多能干细胞在体外研究突触可塑性。最后，我们讨论了将突触功能障碍的基础科学研究与临床和转化研究连接起来的当前进展和未来技术，这些研究可用于预测治疗反应和开发新型疗法。

引用次数: 0

Does stigma leave its mark? The interplay between negative effects of perceived stigma with positive effect of self-esteem on long-term social functioning in schizophrenia 成见会留下印记吗？认知成见的负面影响与自尊对精神分裂症患者长期社会功能的正面影响之间的相互作用

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-10-31 DOI: 10.1016/j.schres.2024.10.011

Mariam P. Ali , Natalia Tiles-Sar , Claudia J.P. Simons , Dominika A. Osicka , GROUP Investigators , Tesfa Dejenie Habtewold , Lisette Van der Meer , Richard Bruggeman , Behrooz Z. Alizadeh

Background

Individuals with schizophrenia commonly experience poor social functioning (SF), influenced by stigmatization and linked to low self-esteem. The intricate role of self-esteem in this context remains insufficiently explored. This study delves into the short and long-term impact of perceived stigma on SF, investigating the mediating or moderating effects of self-esteem and momentary fluctuations in self-esteem.

Methods

Data were derived from a longitudinal cohort of individuals with schizophrenia and related disorders from the 2nd (T₁) and 3rd (T₂) waves. Perceived stigma and self-esteem were measured at T₁ with self-report questionnaires. Self-esteem at T₂ was measured with the experience sampling method. SF was measured at both time points. Multiple regression was applied to analyse the effect of perceived stigma and the role of (fluctuations in) self-esteem on SF.

Results

Perceived stigma significantly correlated with SF in the short-term (β = −4.66, SE = 1.24, p < 0.001) and long-term (β = −3.77, SE = 0.51, p < 0.001). Once we analysed samples with self-esteem (N = 157), stigma was still associated with SF (β = −2.78, SE = 1.36, p = 0.043), but not when self-esteem was controlled for (β = −2.13, SE = 1.34, p < 0.100). Self-esteem significantly mediated stigma-SF relationship in T₁ whereas in T₂ it only significantly predicted SF (β = 2.17, SE = 0.70, p = 0.002). Fluctuations in self-esteem did not show mediating/moderating effects.

Conclusion

Perceived stigma significantly predicts poor SF both concurrently and, to some extent, over the long term. Moreover, self-esteem may serve as a buffer that mitigates the negative impact of perceived stigma. Early interventions aimed at reducing stigma and enhancing self-esteem through anti-stigma initiatives are essential for improving SF.

背景精神分裂症患者通常社会功能低下（SF），这是受污名化的影响，并与自卑有关。在这种情况下，自尊的复杂作用仍未得到充分探讨。本研究深入探讨了感知到的耻辱感对社会功能的短期和长期影响，调查了自尊和自尊的瞬间波动的中介或调节作用。在 T1 阶段，通过自我报告问卷对感知到的耻辱感和自尊进行了测量。T2 阶段的自尊采用经验抽样法进行测量。SF 在两个时间点都进行了测量。结果在短期（β = -4.66，SE = 1.24，p < 0.001）和长期（β = -3.77，SE = 0.51，p < 0.001），感知到的成见与 SF 显著相关。当我们分析具有自尊的样本（N = 157）时，成见仍与 SF 相关（β = -2.78，SE = 1.36，p = 0.043），但当自尊受到控制时，成见与 SF 的相关性就不存在了（β = -2.13，SE = 1.34，p <0.100）。在 T1 中，自尊对成见与 SF 的关系有明显的中介作用，而在 T2 中，自尊仅对 SF 有明显的预测作用（β = 2.17，SE = 0.70，p = 0.002）。自尊的波动没有显示出中介/调节作用。此外，自尊可作为一种缓冲，减轻感知到的成见的负面影响。旨在通过反污名化措施减少污名化和增强自尊的早期干预对于改善自理能力至关重要。

{"title":"Does stigma leave its mark? The interplay between negative effects of perceived stigma with positive effect of self-esteem on long-term social functioning in schizophrenia","authors":"Mariam P. Ali , Natalia Tiles-Sar , Claudia J.P. Simons , Dominika A. Osicka , GROUP Investigators , Tesfa Dejenie Habtewold , Lisette Van der Meer , Richard Bruggeman , Behrooz Z. Alizadeh","doi":"10.1016/j.schres.2024.10.011","DOIUrl":"10.1016/j.schres.2024.10.011","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with schizophrenia commonly experience poor social functioning (SF), influenced by stigmatization and linked to low self-esteem. The intricate role of self-esteem in this context remains insufficiently explored. This study delves into the short and long-term impact of perceived stigma on SF, investigating the mediating or moderating effects of self-esteem and momentary fluctuations in self-esteem.</div></div><div><h3>Methods</h3><div>Data were derived from a longitudinal cohort of individuals with schizophrenia and related disorders from the 2nd (T<sub>1</sub>) and 3rd (T<sub>2</sub>) waves. Perceived stigma and self-esteem were measured at T<sub>1</sub> with self-report questionnaires. Self-esteem at T<sub>2</sub> was measured with the experience sampling method. SF was measured at both time points. Multiple regression was applied to analyse the effect of perceived stigma and the role of (fluctuations in) self-esteem on SF.</div></div><div><h3>Results</h3><div>Perceived stigma significantly correlated with SF in the short-term (β = −4.66, <em>SE</em> = 1.24, <em>p</em> < 0.001) and long-term (β = −3.77, SE = 0.51, <em>p</em> < 0.001). Once we analysed samples with self-esteem (<em>N</em> = 157), stigma was still associated with SF (β = −2.78, SE = 1.36, <em>p</em> = 0.043), but not when self-esteem was controlled for (β = −2.13, SE = 1.34, <em>p</em> < 0.100). Self-esteem significantly mediated stigma-SF relationship in T<sub>1</sub> whereas in T<sub>2</sub> it only significantly predicted SF (β = 2.17, SE = 0.70, <em>p</em> = 0.002). Fluctuations in self-esteem did not show mediating/moderating effects.</div></div><div><h3>Conclusion</h3><div>Perceived stigma significantly predicts poor SF both concurrently and, to some extent, over the long term. Moreover, self-esteem may serve as a buffer that mitigates the negative impact of perceived stigma. Early interventions aimed at reducing stigma and enhancing self-esteem through anti-stigma initiatives are essential for improving SF.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 417-426"},"PeriodicalIF":3.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality indicators for schizophrenia care: A scoping review 精神分裂症护理质量指标：范围审查

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-10-31 DOI: 10.1016/j.schres.2024.10.013

Jennifer C. Anderson , Dallas P. Seitz , David Crockford , Donald Addington , Hanji Baek , Diane L. Lorenzetti , Rebecca Barry , James M. Bolton , Valerie H. Taylor , Paul Kurdyak , Julia Kirkham

Measuring quality of care is a critical first step towards improving the healthcare contributing to persistent poor outcomes experienced by many people living with schizophrenia. This scoping review aims to identify and characterize indicators for measuring the quality of care for people living with schizophrenia. We searched 6 academic databases, 4 grey literature databases, and 23 organization websites for documents containing quality indicators developed for or applied in a population with schizophrenia-spectrum disorders. We identified 119 unique documents, yielding 390 distinct quality indicators. Most measures were process indicators (68 %; n = 267) commonly reflecting safety (30 %; n = 118) and effectiveness (35 %; n = 136) domains of quality of care. Quality indicators included measures of primarily mental healthcare (77 %; n = 299), as well as physical healthcare (23 %; n = 91). Indicators reflected aspects of care related to service delivery, pharmacotherapy, assessments, resources and policies, psychological interventions, social and other interventions. Indicator development was notable for a lack of well-described validation and selection processes. Gaps in indicator availability for comorbid substance use, reproductive health, and healthcare equity were also identified. Results reflect a growing recognition of the importance of quality measurement in this population but highlight the need for prioritization of indicators to guide future quality measurement and improvement.

衡量医疗质量是改善医疗服务的关键第一步，而医疗服务质量低下则是造成许多精神分裂症患者治疗效果持续不佳的原因之一。本范围综述旨在确定和描述衡量精神分裂症患者护理质量的指标。我们检索了 6 个学术数据库、4 个灰色文献数据库和 23 个机构网站，以查找包含为精神分裂症谱系障碍患者制定或应用的质量指标的文献。我们发现了 119 篇独特的文献，共产生了 390 个不同的质量指标。大多数指标都是过程指标（68%；n = 267），通常反映了医疗质量的安全性（30%；n = 118）和有效性（35%；n = 136）。质量指标主要包括精神医疗（77%；n = 299）和身体医疗（23%；n = 91）。指标反映了与服务提供、药物治疗、评估、资源和政策、心理干预、社会和其他干预相关的护理方面。指标制定的显著特点是缺乏完善的验证和选择过程。此外，还发现在合并药物使用、生殖健康和医疗保健公平方面的指标可用性存在差距。研究结果表明，人们日益认识到对这一人群进行质量测量的重要性，但同时也强调需要确定指标的优先次序，以指导未来的质量测量和改进工作。

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引用次数: 0

Visual remediation of contrast processing impairments in schizophrenia: A preliminary clinical trial 对精神分裂症患者对比度处理障碍的视觉补救：初步临床试验

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-10-30 DOI: 10.1016/j.schres.2024.10.010

Zachary Bergson , Anthony O. Ahmed , Jewel Bell , Pamela D. Butler , James Gordon , Aaron R. Seitz , Steven M. Silverstein , Judy L. Thompson , Vance Zemon

Schizophrenia (SZ) is associated with visual processing impairments, which are related to higher-level functional impairments. This study investigated the impact of a novel visual remediation intervention (VisR) targeting low- and mid-level visual processing impairments in SZ. We hypothesized that VisR would lead to greater improvements in contrast processing when compared to an active control condition and explored potential treatment-related changes in symptom severity. SZ participants (N = 47) were randomized into one of four groups: an active control group (cognitive training; AC); Contrast Sensitivity Training + AC (CST + AC); Contour Integration Training + AC (CIT + AC); and CST + CIT. Participants completed 20–40 training sessions. Clinical symptom severity was assessed using the Positive and Negative Syndrome Scale and contrast processing was assessed using steady-state visual evoked potentials to increasing levels of contrast of isolated-check pattern stimuli. A significant Group × Timepoint × Contrast interaction indicated superiority of CST + CIT over AC for improving contrast processing. Furthermore, a large, significant Group × Timepoint interaction indicated that CST + CIT was associated with a greater reduction in positive symptoms compared to AC. In addition, lower severity of positive symptoms at baseline was associated with a greater improvement in contrast processing over the course of treatment. This initial evaluation of VisR demonstrated that it is well tolerated and may produce greater improvements in contrast processing and positive symptoms compared to an intervention targeting only high-level cognitive functions.

精神分裂症（SZ）与视觉处理障碍有关，而视觉处理障碍又与高级功能障碍相关。本研究调查了一种新型视觉矫正干预（VisR）对精神分裂症中低级视觉处理障碍的影响。我们假设，与积极的对照组相比，VisR 将在对比度处理方面带来更大的改善，并探讨了与治疗相关的症状严重程度的潜在变化。SZ 参与者（N = 47）被随机分为四组：积极对照组（认知训练；AC）；对比敏感度训练 + AC（CST + AC）；轮廓整合训练 + AC（CIT + AC）；以及 CST + CIT。参与者完成 20-40 次训练。临床症状严重程度采用正负综合征量表进行评估，对比度处理采用稳态视觉诱发电位对对比度不断增加的孤立检查模式刺激进行评估。组别 × 时间点 × 对比度的交互作用非常明显，表明 CST + CIT 在改善对比度处理方面优于 AC。此外，"组别 × 时间点 "的交互作用也非常明显，表明与 AC 相比，CST + CIT 能更有效地减少阳性症状。此外，在治疗过程中，基线阳性症状的严重程度越低，对比度处理的改善程度就越大。对 VisR 的初步评估表明，与只针对高级认知功能的干预相比，VisR 的耐受性良好，并能在对比处理和阳性症状方面产生更大的改善。

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引用次数: 0

Mortality among older people with late-onset and non-late-onset schizophrenia: A 5-year prospective multicenter study 晚期和非晚期精神分裂症老年人的死亡率：一项为期 5 年的前瞻性多中心研究。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-10-30 DOI: 10.1016/j.schres.2024.10.014

Katayoun Rezaei , Marina Sánchez-Rico , María Sofia Garcés-González , Pierre Vandel , Jean-Pierre Schuster , Carlos Blanco , Frédéric Limosin , Nicolas Hoertel , CSA Study Group

引用次数: 0