Schizophrenia Research最新文献_第8页

Acceptance and Commitment Therapy-based Lifestyle Counselling Program for people with early psychosis on physical activity: A pilot randomized controlled trial 接受与承诺治疗为基础的生活方式辅导计划对早期精神病患者的身体活动：一项随机对照试验。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-28 DOI: 10.1016/j.schres.2024.11.007

Yuen Yu Chong , Wai Tong Chien , Huanyu Mou , Chi Kin Ip , Daniel Bressington

Objective

To evaluate the feasibility, acceptability and efficacy of an Acceptance and Commitment Therapy-based Lifestyle Counselling Program (ACT-LCP) on health outcomes of individuals with early psychosis.

Methods

In this assessor-blinded, parallel-group pilot randomized controlled trial, 72 early psychosis patients (mean age [SD] = 30.51 [8.02], 58.3 % female) were randomized to either the ACT-LCP group or a control group. The ACT-LCP group underwent a five-week group program focusing on ACT-based motivation for healthy lifestyles, a booster session, and two follow-up calls. The control group received standard care, one lifestyle education session, and three follow-up calls. Outcomes including physical activity, autonomous motivation, psychological flexibility, mental status, and quality of life were measured at baseline, 1-week, and 12-week post-intervention. Recruitment, retention, and adherence rates were evaluated. Focus group interviews explored participants' experiences.

Results

Generalized estimating equation models demonstrated that when compared to the Control group, the ACT-LCP group showed a sixfold likelihood of engaging in at least 150 min of moderate to vigorous physical activity per week (adjusted prevalence ratio = 6.28, 95 % CI [2.09–18.93], P ≤ 0.001) at 12-week post-intervention. Improvements at 12-week also included autonomous motivation (adjusted mean difference, aMD = 4.74; P < .001), psychological inflexibility (aMD = −7.69; P < .001), mental status (aMD = −6.83; P < .001), and quality of life (aMD = 0.46; P = .006). Recruitment was successful at 55.8 %, retention at 89 %, and adherence at 80.6 %. Engagement challenges were noted in focus groups.

Conclusions

The ACT-LCP is feasible and acceptable, demonstrating initial efficacy in individuals with early psychosis. Further research should refine the intervention and explore long-term impacts.

ClinicalTrial.gov Identifier: NCT04916496.

目的：评价基于接受与承诺治疗的生活方式咨询项目（ACT-LCP）对早期精神病患者健康结局的可行性、可接受性和有效性。方法：在本评估盲、平行组先导随机对照试验中，72例早期精神病患者（平均年龄[SD] = 30.51[8.02]， 58.3%为女性）随机分为ACT-LCP组和对照组。ACT-LCP组进行了为期五周的小组计划，重点是基于act的健康生活方式的动机，一次促进会议和两次随访电话。对照组接受标准治疗、一次生活方式教育和3次随访电话。结果包括体力活动、自主动机、心理灵活性、精神状态和生活质量在干预后基线、1周和12周进行测量。评估招募率、留任率和依从率。焦点小组访谈探讨了参与者的经历。结果：广义估计方程模型显示，与对照组相比，ACT-LCP组在干预后12周每周至少进行150分钟中等至剧烈体育活动的可能性为对照组的6倍（校正患病率= 6.28,95% CI [2.09-18.93], P≤0.001）。12周时的改善还包括自主动机(调整后平均差，aMD = 4.74；结论：ACT-LCP是可行和可接受的，对早期精神病患者有初步疗效。进一步的研究应完善干预措施并探索长期影响。临床试验：gov标识符：NCT04916496。

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引用次数: 0

Histopathological evidence of cellular alterations in the dentate gyrus is associated with aberrant RB1CC1-ATG16L1 expression in the hippocampus among older adults with chronic schizophrenia: A pilot post-mortem study 老年慢性精神分裂症患者海马中RB1CC1-ATG16L1异常表达与齿状回细胞改变相关的组织病理学证据：一项初步的死后研究。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-28 DOI: 10.1016/j.schres.2024.11.009

Andreas S. Lappas , Maria Ioannou , Nikos G. Christodoulou

Background

Recent evidence brings autophagy, and specifically the RB1CC1 gene into sharp focus as aetiologically relevant to Schizophrenia. Our understanding of whether and how these genetic signatures translate to cellular functions remains limited.

Material and methods

Post-mortem study of 10 individuals with Schizophrenia and 18 individuals without any neurological/psychiatric disorder, matched for age, sex, post-mortem-interval, pH and BRAAK score. Formalin-fixed, paraffin-embedded, 6 μm sections cut through segments of the anterior, middle and posterior left or right hippocampus were examined for histopathological differences and immunohistochemical expression of RB1CC1 and ATG16L1 proteins.

Results

Dentate gyrus (DG) granule cells area (p = 0.005) and circularity (p = 0.012) were significantly lower among Schizophrenia vs. controls. Antipsychotics were associated with lower circularity (p = 0.007). RB1CC1 and ATG16L1 immunoexpression were positively correlated (p < 0.001) and significantly lower in the CA1 (p = 0.047, p = 0.005, respectively). RB1CC1 immunoexpression was significantly higher in the DG among Schizophrenia vs. controls (p = 0.047,). The latter was more pronounced among donors treated with antipsychotics. Lower ATG16L1 CA1 immunoreactivity was correlated with lower granule cell area (p < 0.001).

Conclusions

For the first time, we present histopathological evidence of morphological alterations in the DG of the human brain in Schizophrenia. We propose that these changes indicate DG developmental arrest, which is associated with diminished RB1CC1-ATG16L1-mediated autophagy initiation in the CA1. We suggest that this is a pathological process, whereas RB1CC1-ATG16L1 upregulation in the DG, and possibly in the CA4, may represent a compensatory/restorative mechanism. Antipsychotics may upregulate RB1CC1-ATG16L1 autophagy initiation. Larger studies are required to validate these findings and explore clinical correlations.

背景：最近的证据使自噬，特别是RB1CC1基因成为精神分裂症病因学相关的焦点。我们对这些遗传特征是否以及如何转化为细胞功能的理解仍然有限。材料和方法：对10名精神分裂症患者和18名无任何神经/精神障碍的患者进行尸检研究，年龄、性别、尸检间隔、pH值和BRAAK评分相匹配。采用福尔马林固定、石蜡包埋、6 μm左右海马前、中、后段切片，检测RB1CC1和ATG16L1蛋白的组织病理学差异和免疫组化表达。结果：精神分裂症患者齿状回（DG）颗粒细胞面积（p = 0.005）和圆度（p = 0.012）明显低于对照组。抗精神病药物与循环度降低相关（p = 0.007）。RB1CC1与ATG16L1免疫表达呈正相关(p)。结论：我们首次提供了精神分裂症患者脑DG形态学改变的组织病理学证据。我们认为这些变化表明DG发育停滞，这与rb1cc1 - atg16l1介导的CA1自噬起始减少有关。我们认为这是一个病理过程，而RB1CC1-ATG16L1在DG和CA4中的上调可能代表了一种代偿/恢复机制。抗精神病药物可能上调RB1CC1-ATG16L1自噬起始。需要更大规模的研究来验证这些发现并探索临床相关性。

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引用次数: 0

The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders 创伤暴露和睡眠功能障碍对家族性精神病高危青少年日常压力的日常影响

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-24 DOI: 10.1016/j.schres.2024.10.024

Elizabeth A. Haudrich , Emily K. Burns , Tina Gupta , Gretchen L. Haas , Leslie E. Horton

Cumulative research finds that exposure to childhood trauma, sleep dysfunction, and high stress levels are prevalent in youth diagnosed with and at-risk for psychotic disorders. However, few studies have investigated the association between nightly sleep and moment-to-moment stress in youth who are at familial high-risk (FHR) for psychotic disorders with varying levels of exposure to childhood trauma. The current study examined the day-to-day associations between trauma severity, nightly sleep duration, and next-day momentary stress in 19 FHR and 19 non-psychiatric youth (ages 13–19 years, 66 % girls). Ecological Momentary Assessment was used to assess these variables across three longitudinal timepoints (baseline, 6-months, and 12-months). The FHR group reported greater trauma severity and shorter sleep duration than the non-psychiatric group. In the whole sample, trauma severity and reduced sleep duration were associated with next-day momentary stress. While group status did not moderate the association between sleep duration and next-day momentary stress, group status did moderate the positive association between trauma severity and next-day momentary stress, showing that the association was specific to the non-psychiatric group. Lastly, the effect of nightly sleep duration on next-day momentary stress was significant and negative, but only at low levels of trauma severity for the whole sample. Findings offer preliminary insights into the associations between trauma severity, sleep duration, and momentary stress. Furthermore, this design can provide a foundation for future research examining environmental and psychosocial risk factors that contribute to symptom progression and prognosis of youth who are genetically vulnerable to psychosis.

累积的研究发现，在被诊断患有精神障碍或有此风险的青少年中，普遍存在童年创伤暴露、睡眠功能障碍和高压力水平。然而，很少有研究调查了不同程度童年创伤暴露的精神病家族高危（FHR）青少年每晚睡眠与每时每刻压力之间的关联。本研究调查了 19 名家族性精神病高危青少年和 19 名非精神病青少年（13-19 岁，66% 为女孩）的创伤严重程度、夜间睡眠时间和次日瞬间压力之间的日常关联。生态瞬间评估用于评估三个纵向时间点（基线、6 个月和 12 个月）的这些变量。与非精神疾病组相比，精神创伤与健康组报告的精神创伤严重程度更高，睡眠时间更短。在整个样本中，创伤严重程度和睡眠时间缩短与第二天的瞬间压力有关。虽然组别状况并不能调节睡眠时间与次日瞬间压力之间的关系，但组别状况却能调节创伤严重程度与次日瞬间压力之间的正相关关系，这表明这种关系是非精神病组所特有的。最后，夜间睡眠时间对翌日瞬间压力的影响是显著的负向影响，但在整个样本中，只有在创伤严重程度较低时才会出现这种情况。研究结果为创伤严重程度、睡眠时间和瞬间压力之间的关联提供了初步见解。此外，这种设计还为今后研究环境和社会心理风险因素奠定了基础，这些因素会导致易受精神病遗传影响的青少年的症状发展和预后。

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引用次数: 0

Co-designing technology to improve psychological therapy for psychosis: SloMo, a blended digital therapy for fear of harm from others 共同设计改善精神病心理治疗的技术：SloMo，一种针对害怕他人伤害的混合数字疗法。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-22 DOI: 10.1016/j.schres.2024.11.004

Amy Hardy , Kathryn M. Taylor , Amy Grant , Louie Christie , Lucy Walsh , Thomas Gant , Rama Gheerawo , Anna Wojdecka , Adrian Westaway , Alexa Münch , Philippa Garety , Thomas Ward

Digital technology is positioned as a potential solution to improving access, experience, and outcomes of psychological therapies for psychosis. Digital solutions need to be fit for purpose and tailored to context to deliver real world benefits. To address this, co-production is often used, where stakeholder involvement informs intervention development. However, co-production in clinical research tends to limit involvement to refining previously identified solutions to known problems. This is not an optimal approach to innovation and risks maintaining inequities. An alternative is inclusive co-design, where the needs of a diverse range of people are collaboratively explored using ethnography, and solutions to address these iteratively developed through user testing. In healthcare, we propose an evidence-based approach to co-design (‘hybrid waterfall-agile’) is required. This is because ‘agile’ exploration of needs and solutions is necessarily constrained by clinical guidelines and regulatory requirements (the ‘waterfall’). This paper provides an overview of evidence-based co-design. We use the example of SloMo, a blended digital therapy for paranoia. We describe our transdisciplinary team collaboration and how this facilitates inclusive lived experience involvement. Our therapy development method is outlined, illustrated by reflections from lived experience team members. Iterative divergent (‘zooming out’) and convergent (‘honing in’) cycles are used to co-design therapy functionality, aesthetics, interactions, and content, supported by stakeholder engagement. We conclude by reflecting on common challenges including sustaining lived experience involvement, adherence to evidence base, regulatory compliance, funding, and project management. Recommendations for navigating these obstacles are provided, with the aim of encouraging innovation in mental healthcare for psychosis.

数字技术被定位为一种潜在的解决方案，可用于改善精神病心理治疗的可及性、体验和疗效。数字解决方案必须符合目的，并根据具体情况量身定制，才能带来实际效益。为了解决这个问题，通常会采用共同生产的方式，让利益相关者参与到干预措施的开发中来。然而，临床研究中的共同生产往往仅限于参与完善先前确定的已知问题解决方案。这并不是一种最佳的创新方法，而且有可能使不公平现象继续存在。另一种替代方法是包容性共同设计，即通过人种学合作探索不同人群的需求，并通过用户测试反复开发解决这些问题的方案。在医疗保健领域，我们提出需要一种基于证据的协同设计方法（"混合瀑布-敏捷"）。这是因为对需求和解决方案的 "敏捷 "探索必然受到临床指南和监管要求（"瀑布式"）的限制。本文概述了基于证据的共同设计。我们以治疗偏执狂的混合数字疗法 SloMo 为例。我们介绍了我们的跨学科团队合作，以及这种合作如何促进包容性的生活经验参与。我们还概述了我们的疗法开发方法，并通过生活体验团队成员的反思加以说明。在利益相关者参与的支持下，通过迭代发散（"放大"）和聚合（"缩小"）循环来共同设计疗法的功能、美学、互动和内容。最后，我们对共同面临的挑战进行了反思，这些挑战包括持续的生活经验参与、对证据基础的坚持、监管合规性、资金和项目管理。我们提出了克服这些障碍的建议，旨在鼓励针对精神病的心理保健创新。

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引用次数: 0

Network analysis of psychotic symptoms in schizophrenia 精神分裂症患者精神症状的网络分析。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.11.002

Hong Cai , Bing Shen , Jian-Xiong Long , Xiao-Lan Huang , Jia-Le Li , Zhi-Cheng Zhong , Yu-Hua Wei , Li Su

Background

Schizophrenia with a wide range of psychotic symptoms which indicate the severity of disorders, risk of relapse, frequency and duration of hospitalization, and decreases social and occupational function. In clinical practice, Positive and Negative Systems Scale always used for assessment the severity of psychotic symptoms of patients with schizophrenia. This network analysis explores the inter-relationship of psychotic symptoms of patients with based on Positive and Negative Systems Scale (PANSS).

Methods

The psychotic symptoms of the patients with schizophrenia were assessed by psychiatrist using PANSS when the first day in hospitalization. The network structure of psychotic symptoms was modelled with a graph and characterized using “Expected Influence” and “Bridge Expected Influence” as influential indices in the symptom network. Network stability was tested using a case-dropping bootstrap procedure. Network Comparison Test (NCT) was conducted to examine whether network characteristics differed on the basis of gender.

Results

A total of 799 patients with schizophrenia were included. The mean age of the included participants was 39.51(standard deviation (SD)13.93). The main finding of the study was Preoccupation, Emotional instability and Anxiety were the most influential psychotic symptoms, while Active social avoidance, Emotional instability and Preoccupation were the most bridge influential psychotic symptoms within the interpret-able level of influential in the network. Gender did not significantly affect the overall network structure.

Conclusion

This influential (Preoccupation, Emotional instability and Anxiety) and bridge influential symptoms (Active social avoidance, Emotional instability and Preoccupation) dimension could be addressed in treatment target and treatment response for the patients with schizophrenia.

背景：精神分裂症具有多种精神病性症状，这些症状表明了精神分裂症的严重程度、复发风险、住院频率和住院时间，并降低了患者的社会和职业功能。在临床实践中，阳性和阴性系统量表通常用于评估精神分裂症患者精神病性症状的严重程度。本网络分析探讨了基于阳性和阴性系统量表（PANSS）的精神分裂症患者精神症状的相互关系：方法：精神科医生在精神分裂症患者住院第一天使用 PANSS 对其精神症状进行评估。精神症状的网络结构采用图形建模，并以 "预期影响 "和 "桥接预期影响 "作为症状网络中的影响指数。网络的稳定性采用个案删除引导程序进行测试。进行了网络比较测试（NCT），以检验网络特征是否因性别而异：结果：共纳入了 799 名精神分裂症患者。参与者的平均年龄为 39.51 岁（标准差为 13.93）。研究的主要发现是 "先入为主"、"情绪不稳定 "和 "焦虑 "是最具影响力的精神症状，而 "主动社交回避"、"情绪不稳定 "和 "先入为主 "则是在可解释的网络影响力范围内最具桥梁影响力的精神症状。性别对整个网络结构没有明显影响：精神分裂症患者的治疗目标和治疗反应可以从这一影响症状（先入为主、情绪不稳定和焦虑）和桥接影响症状（主动社交回避、情绪不稳定和先入为主）维度入手。

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引用次数: 0

Free-water imaging in subcortical gray matter in schizophrenia patients with persistent auditory verbal hallucinations 持续性听觉言语幻觉精神分裂症患者皮层下灰质的自由水成像。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.10.028

Jinguang Li , Jingqi He , Honghong Ren , Zongchang Li , Xiaoqian Ma , Liu Yuan , Lijun Ouyang , Aijun Liao , Huiqing Peng , Ying He , Jinsong Tang , Xiaogang Chen

Subcortical gray matter (SGM) is increasingly linked to the pathophysiology of schizophrenia, specifically auditory verbal hallucinations (AVHs). However, few studies have been conducted on the role of extracellular free-water (FW) and white matter microstructural abnormalities in AVHs within the SGM using the free water elimination technique. We conducted a comprehensive investigation of macroscopic volume, FW, and white matter microstructure in the SGM of 60 schizophrenia patients with persistent AVHs (p-AVH), 36 patients no AVH history (n-AVH), and 43 healthy control participants (HC). No macroscopic volume abnormalities were found in the p-AVH or n-AVH groups. However, abnormalities in both FW and microstructures were detected in multiple SGM structures of individuals with schizophrenia. Importantly, unlike the n-AVH group, the p-AVH group exhibited FW and microstructure abnormalities in the bilateral caudate that correlated with AVH severity. Our findings suggest that regardless of the presence of AVHs, FW and microstructure abnormalities in the SGM are more pronounced than macroscopic volume abnormalities in patients with schizophrenia. The bilateral caudate may be a key factor in the mechanisms underlying AVHs. Additionally, normal FW and microstructure in the bilateral caudate may be a notable characteristic of n-AVH patients.

皮层下灰质（SGM）与精神分裂症（尤其是听觉言语幻觉（AVHs））的病理生理学关系日益密切。然而，关于细胞外自由水（FW）和白质微结构异常在 SGM 内幻听幻觉中的作用，很少有研究采用自由水消除技术。我们对 60 名患有持续性 AVH 的精神分裂症患者（p-AVH）、36 名无 AVH 病史的患者（n-AVH）和 43 名健康对照者（HC）的 SGM 的宏观体积、自由水和白质微结构进行了全面调查。p-AVH 组和 n-AVH 组均未发现宏观体积异常。然而，在精神分裂症患者的多个 SGM 结构中发现了 FW 和微观结构的异常。重要的是，与 n-AVH 组不同，p-AVH 组的双侧尾状体显示出与 AVH 严重程度相关的韧带和微结构异常。我们的研究结果表明，在精神分裂症患者中，无论是否存在 AVH，SGM 的幅宽和微观结构异常都比宏观体积异常更为明显。双侧尾状核可能是导致 AVHs 的关键因素。此外，双侧尾状体的正常幅宽和微观结构可能是 n-AVH 患者的一个显著特征。

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引用次数: 0

Muscarinic deficits - part of a cholinergic-dopaminergic- glutamatergic imbalance in schizophrenia? 肌卡因缺陷--精神分裂症中胆碱能-多巴胺能-谷氨酸能失衡的一部分？

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.11.001

Matcheri S. Keshavan , Pegah Seif , Rajiv Tandon

引用次数: 0

Problematic gambling and psychotic-like experiences: Findings from Japan 问题赌博和类似精神病的经历：日本的研究结果。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-19 DOI: 10.1016/j.schres.2024.11.003

Andrew Stickley , Aya Shirama , Risa Yamada , Tomiki Sumiyoshi

Background

Comparatively little is known about the association between problematic gambling and psychotic-like experiences (PLEs). This study examined the association among adults in the Japanese general population and whether this association differs between men and women.

Methods

Data were analyzed from 3701 individuals that were obtained in an online survey. Information on problematic gambling was assessed with the Japanese short version of the South Oaks Gambling Screen Revised (SOGS-R), while PLEs were measured with the PRIME Screen-Revised (PS-R). Logistic regression was used to examine associations.

Results

In an analysis adjusted for sociodemographic, self-rated health and mental health variables, problematic gambling was associated with significantly higher odds for PLEs (OR: 1.64, 95%CI: 1.07–2.50). When the analysis was stratified by sex, problematic gambling was significantly associated with PLEs in women (OR: 2.80, 95%CI: 1.33–5.89) but not men (OR: 1.32, 95%CI: 0.78–2.22) in the fully adjusted model. No effect modification by sex was found.

Conclusion

Problematic gambling is associated with higher odds for PLEs among adults in Japan. More research is now needed to determine which factors are associated with the co-occurrence of problematic gambling and PLEs and whether this comorbidity is associated with a higher risk for negative gambling-related and other outcomes.

背景：人们对问题赌博与精神病样经历（PLEs）之间的关系知之甚少。本研究调查了日本普通人群中成年人的相关性，以及这种相关性在男性和女性之间是否存在差异：方法：分析了通过在线调查获得的 3701 人的数据。有关问题赌博的信息通过南橡树赌博筛查修订版（South Oaks Gambling Screen Revised，SOGS-R）日语简版进行评估，而 PLEs 则通过 PRIME 筛查修订版（PRIME Screen-Revised，PS-R）进行测量。采用逻辑回归法研究两者之间的关联：在对社会人口学、自评健康和心理健康变量进行调整后的分析中，问题赌博与 PLEs 的几率明显较高相关（OR：1.64，95%CI：1.07-2.50）。当按性别进行分层分析时，在完全调整模型中，女性（OR：2.80，95%CI：1.33-5.89）而男性（OR：1.32，95%CI：0.78-2.22）的问题性赌博与 PLEs 显著相关。结论：问题性赌博与较高的患病几率有关：结论：问题赌博与日本成年人患 PLE 的几率较高有关。现在需要进行更多的研究，以确定哪些因素与问题性赌博和 PLEs 同时发生有关，以及这种并发症是否与赌博相关的负面结果和其他结果的更高风险有关。

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引用次数: 0

Orientation-dependent contextual modulation of contrast in schizophrenia 精神分裂症患者对比度的方向依赖性情境调节

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-09 DOI: 10.1016/j.schres.2024.10.021

Victor J. Pokorny , Scott R. Sponheim , Cheryl A. Olman

Introduction

Schizophrenia is associated with weakened contextual modulation of visual contrast perception, which is generally predicted by population average neural firing rates in primary visual cortex (V1). We use high field fMRI and a novel task to assess V1-instrinsic and V1-extrinsic mechanisms of atypical contextual modulation in schizophrenia.

Methods

We examined the BOLD responses of individuals with schizophrenia (SCZ = 34), bipolar disorder (BP = 25), unaffected first-degree relatives of SCZ (SREL = 20), unaffected first-degree relatives of BP (BPREL = 13) and healthy controls (CON = 23). Participants were presented with near- and far-surrounds oriented at 20° and 70° relative to center gratings.

Results

We observed orientation-dependent modulation of V1 BOLD activation to near-surrounds across groups. In particular, the SCZ and CON groups showed significant orientation-dependent contextual modulation (Cohen's d_z SCZ = 0.56; CON = 0.63). Surprisingly, the direction of the modulation was opposite of predicted: greater BOLD activation for the condition that was expected to produce suppression.

Conclusions

Our results differ from previous reports: we observed successful orientation-dependent modulation of V1 activation in SCZ. Furthermore, our results suggest that spatial attention and figure-ground modulation may play an important role in determining the direction and magnitude of orientation-dependent modulation.

简介精神分裂症与视觉对比感知的情境调节减弱有关，这通常是由初级视觉皮层（V1）的群体平均神经发射率预测的。我们使用高场fMRI和一项新任务来评估精神分裂症患者非典型语境调制的V1内在和V1外在机制：我们研究了精神分裂症患者（SCZ = 34）、双相情感障碍患者（BP = 25）、SCZ 患者未受影响的一级亲属（SREL = 20）、BP 患者未受影响的一级亲属（BPREL = 13）和健康对照组（CON = 23）的 BOLD 反应。研究人员向参与者展示了相对于中心光栅20°和70°的近圆和远圆：结果：我们观察到各组V1 BOLD激活对近圆环的定向调节。特别是，SCZ组和CON组显示出显著的方位依赖性情境调节（Cohen's dz SCZ = 0.56; CON = 0.63）。令人惊讶的是，调制的方向与预测相反：在预期会产生抑制的条件下，BOLD激活更强：我们的研究结果与之前的报告不同：我们观察到，在 SCZ 中，V1 激活成功地受到了方向依赖性调节。此外，我们的研究结果表明，空间注意力和图形-地面调制可能在决定方位依赖性调制的方向和幅度方面起着重要作用。

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引用次数: 0

Self-disturbance in schizophrenia: Updating the research and bridging the gaps 精神分裂症的自我干扰：更新研究，缩小差距。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research

Pub Date : 2024-11-08 DOI: 10.1016/j.schres.2024.10.017

Amy M. Jimenez, Michael F. Green

引用次数: 0