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Bayesian analysis to detect change-point in two-phase Laplace model 用贝叶斯分析方法检测两相拉普拉斯模型的变点
Pub Date : 2016-09-30 DOI: 10.5897/SRE2016.6441
A. Jafari, M. Yarmohammadi, A. Rasekhi
The general form of the change-point problem is to determine the unknown location , based on an ordered sequence of observations such that, the two groups of observation and follow distinct models. In this paper the problem of changepoint detection of two-phase Laplace model is considered. Our object is to find the location of random variables where the parameters of their model are changed. The Bayesian method is used to estimate the parameters. Then by simulation studies, the implementation of proposed method will be discussed. For estimate the parameters of the model, and the procedure of the change-point detection the R2OpenBUGS Package in R is used. Finally, a few empirical applications are presented to illustrate the usefulness of the procedures.
变点问题的一般形式是根据有序的观测序列确定未知位置,这样,两组观测并遵循不同的模型。本文研究了两相拉普拉斯模型的变点检测问题。我们的目标是找到随机变量模型参数发生变化的位置。采用贝叶斯方法对参数进行估计。然后通过仿真研究,讨论该方法的实现。对于模型的参数估计和变化点检测过程,使用了R语言中的R2OpenBUGS包。最后,提出了几个实证应用来说明这些方法的有效性。
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引用次数: 4
Slow translation of Tropical Africas wealth in medicinal plants into the clinic: Current biomolecular infrastructural capacity and gaps in sub-Saharan universities 热带非洲药用植物财富向临床的缓慢转化:撒哈拉以南地区大学目前的生物分子基础设施能力和差距
Pub Date : 2016-09-15 DOI: 10.5897/SRE2016.6435
P. F. Kamba, Edson Ireeta Munanura, Bruhan Kaggwa, Stephen Lutoti, H. B. Aguma, R. O. Adome
Tropical Africa has one of the world’s largest endowments in medicinal plant diversity. However, this potential has not been translated into pure drugs of proven efficacy and safety synonymous with modern pharmaceuticals. The basis for the slow translation of Tropical Africa’s medicinal plant wealth into value-added medicines acceptable in the doctor’s clinic is not clear. In this work, we sought to understand the patterns of research on African medicinal plants in general, and the capacity of sub-Saharan universities to conduct value-building research on plant-derived medicines in particular, using an extensive online search.  A near-exponential growth in number of publications over the period 2000 to 2015 was found. However, most of the primary literature is on preliminary pharmacological assays and ethnobotany/ethnopharmacology. Only 6% of the publications are on advanced investigations such as isolation, structure elucidation and semi-synthetic optimization of natural compounds, structural studies of drug targets, ligand binding studies and cell biological assays, yet they are fundamental to progression of lead compounds into useful drugs. Assessment of the current biomolecular infrastructure in 25 sub-Saharan universities found severe shortage of essential equipment in many of them. Only 64, 68, 36 and 68% of the sampled universities have high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) equipment, respectively. East, Central and West Africa are particularly deficient in most of the key equipment, and some available are non-functional. The purchase cost of most biomolecular research equipment is between USD 30,000 and USD 500,000. Further analysis shows that the cost of establishing comprehensive biomolecular research infrastructure in at least one university per sub-Saharan nation is negligible relative to their gross domestic products (GDPs). Thus, even with the current economic resources, sub-Saharan African countries would upgrade biomolecular research capabilities in their leading universities without disrupting other economic priorities. Key words: Medicinal plants, biomolecular, Tropical Africa, nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), analog synthesis.
热带非洲拥有世界上最大的药用植物多样性资源之一。然而,这种潜力尚未转化为经证实有效和安全的纯药物,与现代药物同义。将热带非洲的药用植物财富缓慢转化为医生诊所可接受的增值药物的基础尚不清楚。在这项工作中,我们试图了解非洲药用植物的研究模式,以及撒哈拉以南地区大学通过广泛的在线搜索,特别是对植物衍生药物进行价值建设研究的能力。研究发现,2000年至2015年期间,该领域的出版物数量呈指数级增长。然而,大多数主要文献是关于初步药理学分析和民族植物学/民族药理学。只有6%的出版物是关于高级研究的,如天然化合物的分离、结构解析和半合成优化、药物靶点的结构研究、配体结合研究和细胞生物学分析,但它们是将先导化合物进展为有用药物的基础。对撒哈拉以南25所大学目前生物分子基础设施的评估发现,其中许多大学严重缺乏基本设备。只有64%、68%、36%和68%的受访大学分别拥有高效液相色谱(HPLC)、气相色谱-质谱(GC-MS)、液相色谱-质谱(LC-MS)和核磁共振(NMR)设备。东非、中非和西非在大多数关键设备方面尤其缺乏,一些现有设备无法使用。大多数生物分子研究设备的采购成本在3万至50万美元之间。进一步的分析表明,每个撒哈拉以南国家在至少一所大学建立全面的生物分子研究基础设施的成本相对于其国内生产总值(gdp)可以忽略不计。因此,即使拥有目前的经济资源,撒哈拉以南非洲国家也可以在不影响其他经济优先事项的情况下,提升其顶尖大学的生物分子研究能力。关键词:药用植物,生物分子,热带非洲,核磁共振,液相色谱-质谱,气相色谱-质谱,模拟物合成
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引用次数: 1
Analysis of the environmental effects of international outsourcing: Study of the iron casting industry 国际外包对环境的影响分析:以铸铁业为例
Pub Date : 2016-08-30 DOI: 10.5897/SRE2016.6421
M. Bahadir
The international outsourcing of intermediate products is a common practice in manufacturing. Although outsourcing labor- and resource-intensive production to developing countries is based on financial motives, the decision should also be evaluated from an environmental perspective at a global scale. In this study, the environmental effects of four supply chain scenarios are analyzed through a life-cycle assessment (LCA) of a cast iron component. The study reveals that when upstream manufacturing activities are performed in Mexico, the Global Warming Potential (GWP), Ozone Depletion Potential (ODP) and ecotoxicity levels might be comparable with those of manufacturing activities performed in the U.S. However, in China- and India-based outsourcing scenarios, the GWP, ODP and ecotoxicity levels are two to three times higher than those of U.S.-based scenarios. The main causes of the higher levels of GWP, ODP and ecotoxicity in China and India are related to differences in the amount of scrap metal usage, sources of electricity generation, transportation modes, material transport distances, and emissions control practices. Key words: Life cycle assessment (LCA), global warming, ozone depletion, ecotoxicity, international trade, metal casting.
中间产品的国际外包是制造业的普遍做法。虽然将劳动和资源密集型生产外包给发展中国家是基于经济动机,但也应该从全球范围的环境角度来评价这一决定。在本研究中,通过铸铁部件的生命周期评估(LCA),分析了四种供应链情景的环境影响。研究表明,当上游制造活动在墨西哥进行时,全球变暖潜能值(GWP)、臭氧消耗潜能值(ODP)和生态毒性水平可能与在美国进行的制造活动相当。然而,在中国和印度的外包情景中,全球变暖潜能值、臭氧消耗潜能值和生态毒性水平比在美国的情景高两到三倍。中国和印度的全球升温潜能值、臭氧耗散值和生态毒性水平较高的主要原因与废金属使用量、发电来源、运输方式、材料运输距离和排放控制措施的差异有关。关键词:生命周期评价,全球变暖,臭氧消耗,生态毒性,国际贸易,金属铸造
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引用次数: 3
Exploring the road to improving knowledge and access to female condom in Nigeria: Evidence from Edo, Delta and Lagos states 探索尼日利亚提高女性安全套知识和获取途径的道路:来自埃多州、三角洲州和拉各斯州的证据
Pub Date : 2016-08-15 DOI: 10.5897/SRE2015.6287
Jamilah Mohammed-Jantabo, Richard Olukolade, S. Adebayo
The female condom is a relatively new product that is intended to serve the dual role of protecting against unwanted pregnancy and sexually transmitted infections (STI). Very few studies have been conducted on the use of female condom in Nigeria. Therefore, information is lacking about its continued use, particularly among women at high risk of HIV and other STI. With the above consideration, the Society for Family Health conducted a quantitative and measuring access and performance (MAP) baseline survey to find out the population of women using a female condom to assess product availability and accessibility using pre-defined criteria for coverage, quality of coverage, access and equity of access in Edo, Delta and Lagos states of Nigeria. Data were entered and cleaned using SPSS 13.0. In general, the MAP study found that female condom suffers from lack of public awareness, limited patronage and stock-out; which may be due to absence of promotional efforts.   To enable a successful acceptability of female condom in the Nigerian market, a comprehensive introductory and outreach programme needs to be developed. There is a need to consider the involvement of men, use of peer educators and service providers who might impact on an individual’s motivation to use the female condom.   Key words: Female condom, Nigeria, knowledge, quantitative method, measuring access and performance (MAP) study, Edo, Delta, Lagos.
女用避孕套是一种相对较新的产品,旨在起到防止意外怀孕和性传播感染(STI)的双重作用。尼日利亚很少对女用避孕套的使用情况进行研究。因此,缺乏关于继续使用的信息,特别是在艾滋病毒和其他性传播感染高风险的妇女中。基于上述考虑,家庭健康协会进行了一项定量和衡量获取和绩效基线调查,以查明使用女用避孕套的妇女人口,并利用尼日利亚埃多州、德尔塔州和拉各斯州预先确定的覆盖范围、质量、获取和公平获取标准,评估产品的可获得性和可获得性。使用SPSS 13.0进行数据录入和清理。总体而言,MAP的研究发现,女用避孕套存在公众意识不足、赞助有限和缺货等问题;这可能是由于缺乏宣传努力。为了使尼日利亚市场能够成功地接受女用避孕套,需要制定一项全面的介绍和推广方案。有必要考虑男性的参与、同伴教育者和服务提供者的使用,因为他们可能会影响个人使用女用避孕套的动机。关键词:女用避孕套,尼日利亚,知识,定量方法,计量获取与绩效(MAP)研究,江户,三角洲,拉各斯
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引用次数: 0
Exploring the association between diabetes mellitus and hearing loss: Genetic mutation, neuropathy and microangiopathy 探讨糖尿病与听力损失的关系:基因突变、神经病变和微血管病变
Pub Date : 2016-07-30 DOI: 10.5897/SRE2016.6423
M. Akbar
Diabetes mellitus (DM) has progressively increased in global prevalence. Recent studies have found that patients with DM may suffer from hearing impairment as a chronic complication. The effect of hearing loss may impair the quality of life of patients which affects functional, social, as well as psychological aspects. Both DM and hearing loss are considered to be associated, although this correlation remains elusive. There are three theories proposed to establish the association, which are microangiopathy, neuropathy and genetic mutation in mitochondrial DNA (mtDNA). This essay will initially discuss the importance of mtDNA mutations and neuropathy, as well as microangiopathy, in developing the expression of deafness in diabetes mellitus. It will also consider the limitation of these respective theories to explain the mechanism of hearing loss in diabetes mellitus patients. Key words: Diabetes mellitus, hearing loss, mtDNA mutation, microangiopathy, neuropathy.
糖尿病(DM)在全球的患病率逐渐上升。最近的研究发现,糖尿病患者的慢性并发症可能是听力受损。听力损失的影响可能会损害患者的生活质量,影响功能,社会和心理方面。糖尿病和听力损失都被认为是相关的,尽管这种相关性仍然难以捉摸。有三种理论提出建立这种关联,即微血管病变,神经病变和线粒体DNA (mtDNA)基因突变。本文将初步讨论mtDNA突变和神经病变以及微血管病变在发展糖尿病耳聋表达中的重要性。同时也考虑了这些理论在解释糖尿病患者听力损失机制方面的局限性。关键词:糖尿病,听力损失,mtDNA突变,微血管病变,神经病变
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引用次数: 1
Modeling of compound layer growth during nitriding of pure iron 纯铁渗氮过程中复合层生长的模拟
Pub Date : 2016-07-15 DOI: 10.5897/SRE2016.6405
E. M. Hernández, J. Otero, A. Jiménez, R. D. Santiago, R. Martinez, F. Castillo, J. Oseguera
This paper presents a physical model which describes the layer growth kinetics and the nitrogen concentration profiles during gaseous or plasma nitriding of pure iron. The model is related to a one dimensional moving boundary value problem where the initial concentration profiles are assumed to be linear and a new boundary condition at the diffusion zone is proposed. The model is solved by using a classical finite difference scheme (FDM-CS) and the Heat Balance Integral Method (HBIM). Due to the proposed boundary condition at the diffusion zone, the numerical solutions can be validated through a simple physical analysis of mass transport theory in the asymptotic time limit. The results obtained are compared, and observed to be in good agreement with available experimental data and other approximate solutions reported in the literature. Key words: Advanced characterization, coatings, plasma nitriding, finite difference, heat balance.
本文提出了一个描述纯铁气体或等离子体氮化过程中氮层生长动力学和氮浓度分布的物理模型。该模型涉及一维移动边值问题,该问题假定初始浓度曲线为线性,并在扩散区提出了一个新的边界条件。该模型采用经典有限差分格式(FDM-CS)和热平衡积分法(HBIM)求解。由于所提出的扩散区边界条件,可以通过在渐近时间限制下对质量输运理论进行简单的物理分析来验证数值解。对所得结果进行了比较,并观察到与现有实验数据和文献中报道的其他近似解符合得很好。关键词:高级表征,涂层,等离子体渗氮,有限差分,热平衡。
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引用次数: 4
New methodology for microarray spot segmentation and gene expression analysis 微阵列斑点分割和基因表达分析的新方法
Pub Date : 2016-06-30 DOI: 10.5897/SRE2015.6378
A. Hudaib, H. Fakhouri, Rawan Ghnemat
DNA microarray analysis is the main core in genome mapping. Each microarray image contains millions of information about genes. Microarray analysis is considered one of the most recent and important technologies in exploring the genome. One of the key steps in microarray analysis is to extract gene information from the gene spots, these information represent gene expression levels in the microarray. This paper proposes a new methodology to improve microarray spot analysis based on spot extracted segments. It concentrates on each spot segment area independently rather than analyzing all the spots area together of the microarray image. This paper provides a formal model to enhance the intensity values obtained from gene expression levels of the microarray at any intensity expressed level. It also this paper presents the adaptive threshold techniques to be used for microarray segmentation. The experimental results show that the mean of the gene expression intensity value was 87.77.   Key words: Microarray images, microarray analysis, image segmentation, gridding, microarray addressing, spot localization, spot extraction.
DNA微阵列分析是基因组定位的核心。每个微阵列图像包含数以百万计的基因信息。微阵列分析被认为是研究基因组最新和最重要的技术之一。从基因斑点中提取基因信息是芯片分析的关键步骤之一,这些信息代表了基因在芯片中的表达水平。本文提出了一种基于斑点提取片段改进芯片斑点分析的新方法。它不是对微阵列图像的所有斑点区域进行综合分析,而是对每个斑点区域进行独立的分析。本文提供了一个形式模型来增强从基因表达水平得到的强度值在任何强度表达水平的微阵列。本文还介绍了用于微阵列分割的自适应阈值技术。实验结果表明,基因表达强度值的平均值为87.77。关键词:微阵列图像,微阵列分析,图像分割,网格划分,微阵列寻址,斑点定位,斑点提取。
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引用次数: 2
Sentiment analysis as a way of web optimization 情感分析作为网页优化的一种方式
Pub Date : 2016-04-30 DOI: 10.5897/SRE2016.6381
M. Osama, K. Ahmad, A. Dana
Web optimization is the process of optimizing the web to increase visibility or rank of websites in search engines. Furthermore, this process is also viewed from multiple perspectives, from optimizing inter-server communication that offers the best responses to users’ queries and provides targeted advertisements to users of a website. With this regard, the process of automatic classification and information extraction from users’ comments, also known as Sentiment Analysis (SA) or opinion mining, becomes vital to offer users the best online experience, based on their preferences. There are numerous algorithms available for SA. Therefore before applying any algorithm for polarity detection, pre-processing on comments is carried out. This study analyzes how we can write an algorithm for performing SA, and how different types of processing that are applied to initial data such as stemming or eliminating stop words affect the performance of this algorithm. The results show that even when a small sample is used, sentiment analysis can be done with a high accuracy (over 70%) if appropriate natural language processing algorithms are applied. Having a method for guessing sentiments could enable us, to excerpt opinions from the internet and predict online customer’s favorites, which could ascertain valuable for commercial or marketing research.
网页优化是优化网页以增加网站在搜索引擎中的可见度或排名的过程。此外,这个过程也从多个角度来看,从优化服务器间通信,为用户的查询提供最佳响应,并为网站用户提供有针对性的广告。在这方面,从用户评论中自动分类和信息提取的过程,也称为情感分析(SA)或意见挖掘,对于根据用户的偏好为用户提供最佳的在线体验变得至关重要。有许多可用于SA的算法。因此,在应用任何极性检测算法之前,都要对注释进行预处理。本研究分析了我们如何编写执行SA的算法,以及应用于初始数据的不同类型的处理(如词干提取或消除停止词)如何影响该算法的性能。结果表明,即使使用小样本,如果应用适当的自然语言处理算法,情感分析也可以以很高的准确率(超过70%)完成。拥有一种猜测情绪的方法可以使我们从互联网上摘录意见并预测在线客户的喜好,这可以确定对商业或营销研究的价值。
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引用次数: 2
Strain field determination using displacement gradient model and unified least-squares technique 利用位移梯度模型和统一最小二乘技术确定应变场
Pub Date : 2016-04-15 DOI: 10.5897/SRE2015.6377
Lin Yi-chun, Han Jen-Yu
Deformation analysis is crucial to applications in geodesy, structural engineering, and geology, of which the main goal is to detect the behaviors of a deformed body. Traditional deformation analyses rely on a limited number of observations and thus give a relatively poor description of the strain field on the entire object. In this study, a method based on the displacement gradient model and unified least-squares adjustment is proposed to improve classical deformation analysis. Corresponding quality assessment and sensitivity analysis are derived accordingly to better assess significant deformation. Furthermore, by applying nearest neighbor searching and a triangulated irregular network, the efficiency of analyzing a vast number of observations is improved. Numerical experiments based on real data suggested that the proposed approach detected behaviors of a deformed body in an effective and efficient way. Consequently, the strain field on an object can be obtained rapidly and accurately using the proposed method and a large point dataset. Key words: Deformation analysis, strain field, dispersed point data, structural health monitoring.
变形分析在大地测量学、结构工程和地质学中有着重要的应用,其主要目的是检测变形体的行为。传统的变形分析依赖于有限数量的观测,因此对整个物体的应变场的描述相对较差。本文提出了一种基于位移梯度模型和统一最小二乘平差的方法来改进经典变形分析。为更好地评价重大变形,推导了相应的质量评价和敏感性分析。此外,通过最近邻搜索和不规则三角网,提高了对大量观测数据的分析效率。基于实际数据的数值实验表明,该方法能够有效地检测变形体的行为。因此,利用该方法和大型点数据集可以快速准确地获得物体上的应变场。关键词:变形分析,应变场,分散点数据,结构健康监测。
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引用次数: 0
Characterization of rain-fed maize-based vegetable production systems in Northern Ghana 加纳北部以玉米为基础的雨养蔬菜生产系统的特征
Pub Date : 2016-03-30 DOI: 10.5897/SRE2015.6326
Y. Issaka, J. Seidu, A. Tenkouano
The study was conducted in Northern Ghana comprising of the Northern, Upper East and Upper West regions. The objective of the study was to analyse maize-based rain-fed vegetable production systems with a view to explore their potential to contribute to food and income security for rural households. A combination of qualitative and quantitative data collection methods were employed during the study. Questionnaires were employed to collect quantitative data, through semi-structured interviews on socio-cultural and economic dimensions of vegetable production including household characteristics, consumer perspectives and the economics of production and consumption of vegetables. The targeted respondents were households and consumers. Rain-fed cereal-based vegetable production is a key component of the traditional farming system in Northern Ghana and served as the main source of vegetables for rural households. The results showed that all households in the study area integrated vegetables with maize mainly for home consumption. Only a few households cultivated vegetables with the sole purpose of income.   Key words: Agriculture, rain-fed, household, vegetable, maize-based, Ghana, farming system.
这项研究是在加纳北部进行的,包括北部、上东部和上西部地区。这项研究的目的是分析以玉米为基础的雨养蔬菜生产系统,以期探索其促进农村家庭粮食和收入保障的潜力。本研究采用定性与定量相结合的数据收集方法。通过对蔬菜生产的社会文化和经济维度的半结构化访谈,包括家庭特征、消费者观点以及蔬菜生产和消费的经济学,采用问卷调查收集定量数据。调查对象是家庭和消费者。以雨养谷物为基础的蔬菜生产是加纳北部传统农业系统的关键组成部分,也是农村家庭蔬菜的主要来源。结果表明:研究区所有家庭均以蔬菜为主,玉米为主,以家庭消费为主。只有少数家庭种植蔬菜的唯一目的是赚取收入。关键词:农业,雨养,家庭,蔬菜,玉米为主,加纳,耕作制度。
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引用次数: 2
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