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The association between excess weight and COVID-19 outcomes: An umbrella review 超重与 COVID-19 结果之间的关联:综述。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-03 DOI: 10.1111/obr.13803
Jamie Matu, Alex Griffiths, Oliver M. Shannon, Andrew Jones, Rhiannon Day, Duncan Radley, Alison Feeley, Lisa Mabbs, Jamie Blackshaw, Naveed Sattar, Louisa Ells

This umbrella review assessed the association between excess weight and COVID-19 outcomes. MEDLINE, PsycINFO, and CINAHL were systematically searched for reviews that assessed the association between excess weight and COVID-19 outcomes. A second-order meta-analysis was conducted on the available data for intensive care unit admission, invasive mechanical ventilation administration, disease severity, hospitalization, and mortality. The quality of included reviews was assessed using the AMSTAR-2 appraisal tool. In total, 52 systematic reviews were included, 49 of which included meta-analyses. The risk of severe outcomes (OR = 1.86; 95% CI: 1.70 to 2.05), intensive care unit admission (OR = 1.58; 95% CI: 1.45 to 1.72), invasive mechanical ventilation administration (OR = 1.70; 95% CI: 1.57 to 1.83), hospitalization (OR = 1.82; 95% CI: 1.61 to 2.05), and mortality (OR = 1.35; 95% CI: 1.24 to 1.48) following COVID-19 infection was significantly higher in individuals living with excess weight compared with those with a healthy weight. There was limited evidence available in the included reviews regarding the influence of moderating factors such as ethnicity, and the majority of included reviews were of poor quality. Obesity appears to represent an important modifiable pre-infection risk factor for severe COVID-19 outcomes, including death.

本综述评估了超重与 COVID-19 结果之间的关系。系统检索了MEDLINE、PsycINFO和CINAHL中评估超重与COVID-19结果相关性的综述。根据重症监护室入院、有创机械通气管理、疾病严重程度、住院和死亡率等可用数据进行了二阶荟萃分析。采用 AMSTAR-2 评估工具对纳入的综述进行了质量评估。共纳入了 52 篇系统综述,其中 49 篇包括荟萃分析。严重后果(OR = 1.86;95% CI:1.70 至 2.05)、入住重症监护室(OR = 1.58;95% CI:1.45 至 1.72)、使用有创机械通气(OR = 1.70;95% CI:1.57 至 1.83)、住院(OR = 1.82;95% CI:1.61 至 2.05),以及 COVID-19 感染后的死亡率(OR = 1.35;95% CI:1.24 至 1.48)。在所纳入的综述中,有关种族等调节因素影响的证据有限,且大部分纳入的综述质量较差。肥胖似乎是导致严重 COVID-19 结果(包括死亡)的一个重要的可调节感染前风险因素。
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引用次数: 0
Episodic future thinking improves intertemporal choice and food choice in individuals with higher weight: A systematic review and meta-analysis 偶发性未来思维可改善体重较重者的时际选择和食物选择:系统回顾和荟萃分析。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-02 DOI: 10.1111/obr.13801
Emily Colton, Mia Connors, Justin Mahlberg, Antonio Verdejo-Garcia

Episodic future thinking (EFT) strengthens self-regulation abilities by increasing the perceived value of long-term reinforcements and reducing impulsive choice in delay discounting tasks. As such, EFT interventions have the potential to improve dietary and eating-related decision-making in individuals with obesity or binge eating symptoms, conditions associated with elevated delay discounting. Here, we meta-analyzed evidence from 12 studies that assessed whether EFT interventions improve delay discounting and real-world food choice compared to control interventions. Included studies involved 951 adults with overweight or obesity (body mass index [BMI] ≥25). There were no studies involving participants with binge eating disorder. EFT intervention pooled effects were significant, improving delay discounting with a medium effect, g = 0.55, p < 0.0001, and subsequent food choice outcomes with a small effect, g = 0.31, p < 0.01. Notably, our review is the first to analyze mechanisms of effect in this population, demonstrating that improvements were greater when temporal horizons of EFT episodes were aligned with delay discounting tasks and more distant horizons predicted far-transfer to subsequent dietary and eating-related choices. Our findings thus show that EFT is an effective intervention for individuals with higher weight at risk of adverse health consequences.

外显未来思维(EFT)能提高长期强化的感知价值,减少延迟折现任务中的冲动选择,从而增强自我调节能力。因此,EFT 干预措施有可能改善肥胖症或暴饮暴食症状患者的饮食相关决策,这些症状与延迟折现升高有关。在此,我们对来自 12 项研究的证据进行了元分析,这些研究评估了与对照干预相比,EFT 干预是否能改善延迟折现和真实世界中的食物选择。纳入的研究涉及 951 名超重或肥胖的成年人(体重指数 [BMI] ≥25)。没有研究涉及暴食症患者。EFT干预的综合效果显著,改善了延迟折现,效果中等,g = 0.55, p
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引用次数: 0
Cardiometabolic implications of adipose tissue aging 脂肪组织老化对心脏代谢的影响
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-30 DOI: 10.1111/obr.13806
Bulbul Ahmed, Melissa G. Farb, Noyan Gokce

Adipose tissue is a large endocrine organ that serves numerous physiological functions. As we age, adipose tissue remodels and can develop functional changes that alters its phenotype, potentially contributing to metabolic and cardiovascular disorders. Aging adipose tissue is characterized by regional redistribution of fat, accumulation of senescent cells, fibrosis, and decline in adipocyte differentiation capacities, which collectively impact adipose tissue function and whole body health. A notable transformation involves increased accumulation of intra-abdominal visceral adipose tissue and ectopic fat around internal organs such as the heart, blood vessels, liver, and kidneys that alter their functions. Other changes associated with aging include alterations in adipokine secretion and changes in adipocyte size and numbers. Aging adipocytes play a role in mediating chronic inflammation, metabolic dysfunction, and insulin resistance. Visceral adipose tissue, which increases in volume with aging, is in particular associated with inflammation, angiogenic dysfunction, and microvascular abnormalities, and mediators released by visceral fat may have adverse consequences systemically in multiple target organs, including the cardiovascular system. Understanding mechanisms underlying adipose tissue aging and its impact on cardiovascular health are important for developing interventions and treatments to promote healthy aging and reduce cardiometabolic disease risk.

脂肪组织是一个大型内分泌器官,具有多种生理功能。随着年龄的增长,脂肪组织会发生重塑和功能变化,从而改变其表型,可能导致代谢和心血管疾病。老化脂肪组织的特点是脂肪的区域性重新分布、衰老细胞的积累、纤维化和脂肪细胞分化能力的下降,这些都会影响脂肪组织的功能和全身健康。一个显著的变化是腹部内脏脂肪组织和内脏器官(如心脏、血管、肝脏和肾脏)周围的异位脂肪堆积增加,从而改变了它们的功能。与衰老相关的其他变化包括脂肪因子分泌的改变以及脂肪细胞大小和数量的变化。老化的脂肪细胞在慢性炎症、代谢功能障碍和胰岛素抵抗中起着介导作用。内脏脂肪组织的体积会随着衰老而增大,尤其与炎症、血管生成功能障碍和微血管异常有关,内脏脂肪释放的介质可能会对包括心血管系统在内的多个靶器官产生不利影响。了解脂肪组织老化的内在机制及其对心血管健康的影响,对于开发干预措施和治疗方法以促进健康老化和降低心血管代谢疾病风险非常重要。
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引用次数: 0
The utility of obesity polygenic risk scores from research to clinical practice: A review 肥胖多基因风险评分从研究到临床实践的效用:综述。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-29 DOI: 10.1111/obr.13810
Philip R. Jansen, Niels Vos, Jorrit van Uhm, Ilona A. Dekkers, Rieneke van der Meer, Marcel M. A. M. Mannens, Mieke M. van Haelst

Obesity represents a major public health emergency worldwide, and its etiology is shaped by a complex interplay of environmental and genetic factors. Over the last decade, polygenic risk scores (PRS) have emerged as a promising tool to quantify an individual's genetic risk of obesity. The field of PRS in obesity genetics is rapidly evolving, shedding new lights on obesity mechanisms and holding promise for contributing to personalized prevention and treatment. Challenges persist in terms of its clinical integration, including the need for further validation in large-scale prospective cohorts, ethical considerations, and implications for health disparities. In this review, we provide a comprehensive overview of PRS for studying the genetics of obesity, spanning from methodological nuances to clinical applications and challenges. We summarize the latest developments in the generation and refinement of PRS for obesity, including advances in methodologies for aggregating genome-wide association study data and improving PRS predictive accuracy, and discuss limitations that need to be overcome to fully realize its potential benefits of PRS in both medicine and public health.

肥胖症是全球重大的公共卫生问题,其病因是由环境和遗传因素的复杂相互作用造成的。在过去十年中,多基因风险评分(PRS)已成为量化个人肥胖遗传风险的一种有前途的工具。肥胖遗传学领域的多基因风险评分正在迅速发展,为肥胖症的发病机制提供了新的线索,并有望为个性化预防和治疗做出贡献。在临床整合方面仍存在挑战,包括需要在大规模前瞻性队列中进一步验证、伦理考虑以及对健康差异的影响。在这篇综述中,我们全面概述了用于研究肥胖遗传学的 PRS,从方法学的细微差别到临床应用和挑战。我们总结了肥胖症 PRS 生成和完善方面的最新进展,包括全基因组关联研究数据汇总方法的进步和 PRS 预测准确性的提高,并讨论了需要克服的局限性,以充分实现 PRS 在医学和公共卫生方面的潜在益处。
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引用次数: 0
Association of adverse childhood experiences and overweight or obesity in adolescents: A systematic review and network analysis 不良童年经历与青少年超重或肥胖的关系:系统回顾与网络分析。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-29 DOI: 10.1111/obr.13809
Renato Mikio Moriya, Carlos Eduardo Coral de Oliveira, Edna Maria Vissoci Reiche, João Luís Lima Passini, Sandra Odebrecht Vargas Nunes

This systematic review with meta-analysis assessed the effects of adverse childhood experiences (ACEs) linked to overweight or obesity in adolescents. Twenty-eight studies (cross-sectional, case–control, or cohort) were included, which described individuals with a history of ACE or adverse family experiences, such as physical, emotional, or psychological abuses; neglect; exposure to domestic violence or peer violence; and sexual abuse. Body mass index (BMI) or BMI z score was used by the study to define adolescents with overweight or obesity. Adolescents who reported childhood experiences, mainly physical, sexual, and emotional abuses, were more associated with overweight/obesity, especially those who experienced four or more ACEs. Network meta-analysis indicated that physical, sexual, and neglect were the most common ACEs associated with obesity in adolescents. Due to significant differences and imprecision among the studies, network meta-analysis was inconclusive in determining the impact of other types of ACE on outcomes. However, evidence suggests that exposure to sexual and physical abuse, as well as neglect, is associated with adolescents who are obese or overweight, as well as with the number of ACE experienced. The study presented evidence suggesting that dealing with many ACEs may be a risk factor for overweight and obesity in adolescents.

本系统综述和荟萃分析评估了与青少年超重或肥胖有关的童年不良经历(ACE)的影响。共纳入了 28 项研究(横断面、病例对照或队列),这些研究描述了有 ACE 或不良家庭经历史的个体,如身体、情感或心理虐待;忽视;遭受家庭暴力或同伴暴力;以及性虐待。研究用体重指数(BMI)或BMI z 分数来定义超重或肥胖的青少年。报告童年经历(主要是身体虐待、性虐待和情感虐待)的青少年更容易超重/肥胖,尤其是那些经历过四次或四次以上ACE的青少年。网络荟萃分析表明,身体虐待、性虐待和忽视是与青少年肥胖有关的最常见的 ACE。由于各研究之间存在显著差异且不精确,网络荟萃分析无法确定其他类型的 ACE 对结果的影响。不过,有证据表明,遭受性虐待和身体虐待以及忽视与青少年肥胖或超重有关,也与经历的 ACE 数量有关。该研究提出的证据表明,经历许多 ACE 可能是导致青少年超重和肥胖的一个风险因素。
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引用次数: 0
The promising role of Transcendental Meditation in the prevention and treatment of cardiometabolic diseases: A systematic review 超凡冥想在预防和治疗心脏代谢疾病方面的作用前景广阔:系统综述。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-28 DOI: 10.1111/obr.13800
Mahesh Kumar Khanal, Leila Karimi, Peter Saunders, Robert H. Schneider, John Salerno, Karen Livesay, Karen T. Hallam, Barbora de Courten

Psychological distress has a demonstrable impact on cardiovascular diseases (CVD) and risk factors. Transcendental Meditation (TM) has been shown to reduce stress and improve health and well-being. The current review aimed to synthesize the evidence on the effects of TM on cardiometabolic outcomes and identify gaps for future research. We searched PubMed/MEDLINE, EMBASE, SCOPUS, and Web of Science databases for relevant literature. Forty-five papers that reported studies of TM on cardiometabolic risk factors and diseases were included. Evidence shows that TM is effective in reducing blood pressure (BP). We found some evidence that TM can improve insulin resistance and may play a role in improving dyslipidemia, exercise tolerance, and myocardial blood flow, and in reducing carotid intima-media thickness and left ventricular mass. Studies show that long-term TM practice can reduce the risk of myocardial infarction, stroke, and CVD mortality. This review identified that certain studies have high participant drop-out rates, and fewer studies targeted comprehensive cardiometabolic outcomes beyond BP with longer follow-up periods. We found that most studies were conducted in specific populations, which may limit generalizability. In conclusion, TM has the potential to improve cardiometabolic health; however, research gaps highlight the need for larger phase III multicenter clinical trials with long-term follow-ups.

心理压力对心血管疾病(CVD)和风险因素有明显的影响。超觉静坐(TM)已被证明可以减轻压力,改善健康和幸福感。本综述旨在综合 TM 对心血管代谢结果影响的证据,并找出未来研究的不足之处。我们检索了 PubMed/MEDLINE、EMBASE、SCOPUS 和 Web of Science 数据库中的相关文献。共收录了 45 篇报告 TM 对心脏代谢风险因素和疾病研究的论文。有证据表明 TM 能有效降低血压(BP)。我们发现一些证据表明,TM 可以改善胰岛素抵抗,并在改善血脂异常、运动耐量和心肌血流量,以及减少颈动脉内膜厚度和左心室质量方面发挥作用。研究表明,长期练习 TM 可以降低心肌梗死、中风和心血管疾病死亡的风险。本综述发现,某些研究的参与者退出率较高,而针对血压以外的综合心血管代谢结果、随访时间较长的研究较少。我们发现,大多数研究都是在特定人群中进行的,这可能会限制研究的普遍性。总之,TM 有改善心血管代谢健康的潜力;但是,研究差距凸显了进行长期随访的大型 III 期多中心临床试验的必要性。
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引用次数: 0
Overcoming underestimation of the association of excess weight with pancreatic cancer due to prediagnostic weight loss: Umbrella review of systematic reviews, meta-analyses, and pooled-analyses 克服因诊断前体重减轻而低估超重与胰腺癌关系的问题:对系统综述、荟萃分析和汇总分析的总体回顾。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-25 DOI: 10.1111/obr.13799
Marko Mandic, Dianne Pulte, Fatemeh Safizadeh, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner

Elevated body mass index (BMI) is linked to increased pancreatic cancer (PC) risk. Cancer-associated weight loss can occur years before the malignancy is diagnosed. This might have led to underestimation of the BMI-PC association. However, it is unknown if and to what extent this issue has been considered in previous epidemiological studies. We searched two databases through February 19, 2024 for systematic reviews, meta-analyses, and pooled analyses examining the BMI-PC association. We extracted information on study design with a special focus on the article's examination of prediagnostic weight loss as a potential source of bias, as well as how included cohort studies addressed this concern. Thirteen review articles, meta-analyses, and pooled analyses were identified. Only five (four pooled analyses, one systematic review) considered prediagnostic weight loss in their analyses. Twenty-four of 32 identified cohort studies reported having excluded initial years of follow-up. However, only 13 studies reported results after such exclusions, and effect estimates generally increased with longer periods of exclusion. We conclude that the association of overweight and obesity with PC risk is likely larger than suggested by published epidemiological evidence. Future studies should pay careful attention to avoid or minimize potential bias resulting from prediagnostic weight loss.

体重指数(BMI)升高与胰腺癌(PC)风险增加有关。癌症相关的体重减轻可能发生在恶性肿瘤确诊前数年。这可能会导致低估体重指数与胰腺癌的关系。然而,以往的流行病学研究是否以及在多大程度上考虑了这一问题尚不得而知。截至 2024 年 2 月 19 日,我们在两个数据库中检索了研究 BMI-PC 关联的系统综述、荟萃分析和汇总分析。我们提取了有关研究设计的信息,重点关注文章对诊断前体重减轻这一潜在偏倚来源的研究,以及所纳入的队列研究如何解决这一问题。共确定了 13 篇综述文章、荟萃分析和汇总分析。只有五篇(四篇汇总分析,一篇系统综述)在分析中考虑了诊断前体重减轻。在 32 项已确定的队列研究中,有 24 项报告排除了最初几年的随访。然而,只有 13 项研究报告了剔除后的结果,而且效果估计值通常随着剔除时间的延长而增加。我们的结论是,超重和肥胖与 PC 风险之间的关联可能大于已发表的流行病学证据所显示的关联。今后的研究应注意避免或尽量减少诊断前体重减轻造成的潜在偏倚。
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引用次数: 0
Association between preconception body mass index and fertility in adult female: A systematic review and meta-analysis 孕前体重指数与成年女性生育能力的关系:系统回顾和荟萃分析。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-25 DOI: 10.1111/obr.13804
Jixing Zhou, Yi Zhang, Yuzhu Teng, Lianjie Dou, Huiru Chen, Fangbiao Tao, Kun Huang

Obesity potentially reduces fertility, but systematic reviews are lacking to summarize the existing literature. Therefore, we systematically summarized the association between preconception body mass index (BMI) and fertility in adult female based on existing reports. Up to September 2023, we conducted literature retrievals in different databases, including Web of Science, PubMed, Wiley, and ScienceDirect. Finally, 18 studies were included. Female with overweight/obesity (FOR = 0.85; 95% CI: 0.80, 0.90), obesity (FOR = 0.76; 95% CI: 0.69, 0.83), and overweight (FOR = 0.93; 95% CI: 0.88, 0.99) was associated with the significant time-to-pregnancy (TTP) prolongation (reduced fecundability). Interestingly, underweight was moderately associated with prolonged TTP in females (FOR = 0.95; 95% CI: 0.91, 0.99). Female overweight/obesity was associated with an increased risk of subfecundity (OR = 1.44; 95% CI: 1.20, 1.72) and infertility (OR = 1.60, 95% CI: 1.31–1.94). The findings emphasize the importance of considering appropriate preconception BMI at the population level for female fertility outcomes. In particular, prepregnancy obesity in females is strongly associated with prolonged TTP and increased risk of subfecundity. Scientific management of preconception BMI may improve fertility.

肥胖可能会降低生育能力,但缺乏系统性综述来总结现有文献。因此,我们根据现有的报道,系统地总结了孕前体重指数(BMI)与成年女性生育能力之间的关系。截至 2023 年 9 月,我们在不同的数据库中进行了文献检索,包括 Web of Science、PubMed、Wiley 和 ScienceDirect。最后,共纳入了 18 项研究。女性超重/肥胖(FOR = 0.85; 95% CI: 0.80, 0.90)、肥胖(FOR = 0.76; 95% CI: 0.69, 0.83)和超重(FOR = 0.93; 95% CI: 0.88, 0.99)与怀孕时间(TTP)显著延长(受孕率降低)有关。有趣的是,女性体重不足与受孕时间延长呈中度相关(FOR = 0.95;95% CI:0.91,0.99)。女性超重/肥胖与亚生育(OR = 1.44;95% CI:1.20,1.72)和不育(OR = 1.60,95% CI:1.31-1.94)风险增加有关。研究结果强调了在人群水平上考虑适当的孕前体重指数对女性生育结果的重要性。尤其是,女性孕前肥胖与 TTP 延长和亚育风险增加密切相关。科学管理孕前体重指数可提高生育能力。
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引用次数: 0
Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight-loss interventions 瘦素是儿童肥胖症的潜在生物标志物,也是减肥干预效果的指标。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-23 DOI: 10.1111/obr.13807
Mohammad Al Zein, Aishat Funmilayo Akomolafe, Fathima R. Mahmood, Ali Khrayzat, Amirhossein Sahebkar, Gianfranco Pintus, Firas Kobeissy, Ali H. Eid

Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. Furthermore, weight-loss programs often exhibit reduced effectiveness in adults who have a history of childhood obesity. Therefore, early intervention against childhood obesity is imperative. Presently, the primary method for diagnosing childhood obesity relies on body mass index (BMI), yet this approach has inherent limitations. Leptin, a satiety hormone produced by adipocytes, holds promise as a superior tool for predicting both childhood and subsequent adulthood obesity. In this review, we elucidate the tools employed for assessing obesity in children, delve into the biological functions of leptin, and examine the factors governing its expression. Additionally, we discuss maternal and infantile leptin levels as predictors of childhood obesity. By exploring the relationship between leptin levels and weight loss, we present leptin as a potential indicator of the effectiveness of obesity interventions.

儿童肥胖症是一个重大的公共卫生问题,给医疗保健系统带来了沉重的负担。此外,减肥计划对有儿童肥胖史的成年人的效果往往会大打折扣。因此,对儿童肥胖症进行早期干预势在必行。目前,诊断儿童肥胖症的主要方法是体重指数(BMI),但这种方法有其固有的局限性。瘦素是一种由脂肪细胞产生的饱腹感激素,有望成为预测儿童肥胖和成年后肥胖的卓越工具。在这篇综述中,我们将阐明用于评估儿童肥胖症的工具,深入探讨瘦素的生物功能,并研究影响瘦素表达的因素。此外,我们还讨论了作为儿童肥胖症预测因素的母体和婴儿瘦素水平。通过探讨瘦素水平与体重减轻之间的关系,我们将瘦素作为肥胖症干预措施有效性的潜在指标。
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引用次数: 0
Attention-deficit/hyperactivity disorder in adolescent and adult candidates for metabolic and bariatric surgery: A systematic review and meta-analysis 青少年和成人代谢与减肥手术候选者的注意力缺陷/多动症:系统回顾和荟萃分析。
IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-23 DOI: 10.1111/obr.13802
Hervé Caci, Andrea Chierici, Antonio Iannelli

Aims

Attention-deficit with hyperactivity disorder (ADHD) is associated with obesity and impacts the outcome of metabolic and bariatric surgery (MBS). This study aimed at calculating the prevalence in candidates for MBS, which is yet unclear.

Methods

We conducted a systematic review and meta-analysis, searching three databases from their respective inception to December 2022 for studies reporting the prevalence of ADHD in adolescents and adults assessed before undergoing MBS. The protocol was registered in PROSPERO (CRD42022384914). We adhered to Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines; the quality of studies was assessed with the JBI Critical Appraisal checklist. Random-effect meta-analyses were performed; confidence intervals were computed with a binomial exact method, and the pooled estimate was calculated after double arcsine transformation.

Findings

Fourteen studies (24,455 adults) and three studies (299 adolescents) were selected. The quality of studies was moderate to poor; meta-analyses were performed on subgroups according to the case definition used. The prevalence is 8.94% and 9.90% in adults, and 28.73% in adolescents.

Conclusions

ADHD is three times more frequent in adults and six times more frequent in adolescents than in the general population. Recommendations are provided to improve the quality of future studies and obtain more reliable estimates of prevalence.

目的:注意力缺陷多动障碍(ADHD)与肥胖有关,并影响代谢和减肥手术(MBS)的效果。本研究旨在计算注意力缺陷多动障碍在代谢与减肥手术(MBS)候选者中的发病率,目前这一问题尚不清楚:我们进行了一项系统性回顾和荟萃分析,在三个数据库中搜索了从各自开始到 2022 年 12 月的有关青少年和成人在接受 MBS 之前多动症患病率的研究报告。研究方案已在 PROSPERO(CRD42022384914)上注册。我们遵循《流行病学观察性研究的荟萃分析》(MOOSE)和《系统综述和荟萃分析的首选报告项目》(PRISMA)2020 指南;研究质量采用 JBI 批判性评估核对表进行评估。进行了随机效应荟萃分析;采用二项式精确法计算置信区间,并在双弧线变换后计算汇总估计值:选取了 14 项研究(24 455 名成人)和 3 项研究(299 名青少年)。研究质量为中等至较差;根据所使用的病例定义对亚组进行了荟萃分析。成人发病率为 8.94% 和 9.90%,青少年发病率为 28.73%:与普通人群相比,多动症在成年人中的发病率高出三倍,在青少年中的发病率高出六倍。结论:多动症在成年人中的发病率是普通人群的三倍,在青少年中的发病率是普通人群的六倍,建议提高未来研究的质量,获得更可靠的发病率估计值。
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引用次数: 0
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Obesity Reviews
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