Obesity Reviews最新文献

We systematically assessed evidence of overweight and obesity prevalence, and possible determinants, in people who experience incarceration globally. We searched Embase, Medline, and Cochrane databases. Overweight and obesity proportions were pooled into a meta-analysis and compared with national prevalences. Seventy-one studies met the inclusion criteria; 38 were included in the meta-analysis. Studies in high-income countries reported higher proportions of overweight and obesity (73.3%, 95% CI 73.1, 73.5) than upper-middle-income countries (66.1%, 95% CI 64.1, 67.7) and lower-middle-income countries (52.8%, 95% CI 47.1, 58.1). The prevalence of overweight and obesity in female incarcerated individuals was higher than that in the general population (RD 11.7%, 95% CI 9.1, 14.3), especially in low and middle-income countries (RD 35.1%, 95% CI 29.4, 40.7). The prevalence of overweight and obesity in male incarcerated individuals was lower than that in the general population in all income categories (RD -10.8%, 95% CI -13.2, -8.4). Incarcerated individuals in low and lower-middle-income countries were less likely to achieve sufficient energy intake, fruit/vegetable intake, and sufficient physical activity, compared with high- and upper-middle-income countries. The prevalence of overweight and obesity in incarcerated populations differed between developed and developing countries. Future research should focus on female incarcerated individuals, especially in lower-middle-income countries.

Obesity is a preventable global health epidemic that has serious health consequences. Health literacy has been identified as an underlying and modifiable factor in the development and maintenance of obesity. Adequate levels of health literacy have been shown to significantly impact on weight loss, weight loss maintenance, and associated health outcomes.

Objective: The aim of the current study was to systematically review extant literature to evaluate the way in which health literacy is measured for individuals with obesity and to identify the key areas of health literacy that are commonly assessed.

Method: This systematic scoping review was conducted over five databases and yielded 12 papers (N_participants = 15,393) that represented our search strategy and inclusion and exclusion criteria.

Results: The review highlighted there are currently multiple measures that exist that assess independent or dual domains of health literacy; however, there were no studies that specifically utilized a measure that holistically assessed the three maintaining and modifiable domains of health literacy of obesity (psychological knowledge, nutritional knowledge, and knowledge about physical activity).

Conclusion: Given the dearth of targeted health literacy measures for obesity, our findings highlighted a critical need to develop a distinct measure of health literacy for obesity to guide policy, research, education, and intervention.

Monosodium glutamate (MSG) has become one of the most widely used food additives in the global food supply. Although it has been classified for decades as a food ingredient that is generally recognized as safe, concerns about the health impacts of chronic MSG use, especially its potential effect on weight, are still ongoing. This comprehensive review summarizes the available human and animal evidence, highlighting potential mechanisms linking MSG use to weight gain or obesity, and discusses challenges and future research directions. Because of MSG intake worldwide as well as hidden MSG in food labeling, there is a pressing need for a mechanistic understanding of the health impacts of MSG use especially on weight. To generate robust scientific evidence and to clarify public concerns, rigorous mechanistic studies and randomized controlled clinical trials are warranted.

Weight stigma presents a significant challenge for women throughout the preconception, pregnancy, and postpartum (PPP) periods, manifesting in multiple areas of life, including interpersonal relationships, healthcare settings, and broader social contexts. This systematic review investigates weight stigma in women across their reproductive years, examining its impact, and exploring the socioecological factors that contribute to its persistence. We searched Medline, PsycINFO, Embase, Maternity and Infant Care (MIDIRS), and Global Health for peer-reviewed articles published since 2010. Of the 3486 records identified, 38 were included in a narrative synthesis. Inductive thematic analysis was used to explore women's personal experiences of weight stigma. We then applied a socioecological lens to examine the interrelationships between individual, interpersonal, organizational, and societal factors contributing to weight stigma. Five overarching themes were identified: (1) the impact of weight stigma on PPP women; (2) weight stigma experiences across the socioecological contexts; (3) coping strategies; (4) women's voices as a call to action; and (5) interrelationships of weight stigma contexts. Our findings provide critical insights into the multifaceted nature of weight stigma, highlighting the need for future research, and the development of practical strategies that prioritize women's perspectives, and challenge harmful societal norms for positive change.

Stevia is an intense, calorie-free sweetener that is frequently used to reduce energy intake; however, studies examining its effects on appetite and energy intake have produced mixed results, indicating that a definitive consensus has not yet been reached. This systematic review and meta-analysis aimed to determine the impact of stevia on appetite and energy intake in adults. The PROSPERO registration number for this research is CRD42023414411. The databases PubMed (MEDLINE), Scopus, Web of Science, and Google Scholar were systematically searched. In addition, the reference lists of extracted articles and pertinent reviews were examined. Two evaluators performed screening, quality assessment, and data extraction independently. Furthermore, the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach was employed to systematically assess the certainty level of the evidence presented in our study. Eleven clinical trials with a total of 428 participants were included. We found no significant changes in any appetite scores following stevia consumption (very low to moderate certainty of the evidence). Moreover, subgroup analyses demonstrated the scores of desires to eat increased significantly in the oral intake of stevia and not enteral intake subgroup (WMD: 0.45; 95% CI: 0.009, 0.89; P = 0.046). In addition, the number of studies reporting energy intake was limited, preventing a meta-analysis of this variable. In conclusion, stevia consumption has no significant effect on appetite scores in adults but it seems that more long-term clinical trials are needed to obtain more accurate results. PRACTITIONER POINT: Stevia, as a non-nutritive sweetener, has no significant effect on appetite scores in adults.

The food system significantly affects the environment through land use, emissions from livestock, deforestation, and food waste. Diet sustainability considers the environmental effects of food production, distribution, and consumption. Animal products emit more greenhouse gases than plant-based foods, prompting a shift towards plant-focused diets for reduced emissions. Sustainable diets, like the EAT-Lancet model, prioritize plant-based foods, adjusting for regional eating habits. These diets aim to be both environmentally friendly and conducive to human health, addressing concerns like obesity and chronic diseases. Obesity is a major global health challenge, and its complex relationship with food production and consumption patterns calls for sustainable solutions to reduce pressure on ecosystems and promote healthier lifestyles. Tackling obesity requires holistic strategies that address not only individual health but also the broader environmental impacts of food systems. A systematic review examined the link between plant-based diets and obesity focusing on studies assessing Body Mass Index (BMI) and body fat assessment. Despite limited research, evidence suggests that adherence to a plant-based diet, particularly a healthy one, is associated with lower obesity rates. More longitudinal and intervention studies are necessary for a stronger consensus on the matter.

Retail food environments play a pivotal role in influencing dietary behaviors, and therefore have huge potential as settings for promoting good nutrition and preventing obesity. Conducting research in retail settings can be challenging due to the varied motivations of the parties involved and the complex nature of retail environments. To improve the quality and consistency of research in this field, we have identified 16 thematic topics aimed at guiding researchers and public health practitioners on how to conduct healthy food retail research. A summary for each topic, encompassing existing methodologies, best practice examples, and knowledge gaps, was developed based on available literature and the collective experience and expertise of 32 multidisciplinary researchers from a high-income perspective engaged in healthy food retail research in a diverse range of retail settings. A summary checklist describing key considerations at each stage of conducting healthy food retail research was also developed.

Introduction: Immunotherapy is a crucial treatment for type 1 diabetes (T1D), yet analyses focusing on research priorities and trends in this field are limited. Therefore, this study employs bibliometric methods to systematically explore the current research status of immunotherapy for T1D.

Methods: Based on the Web of Science Core Collection Database, 1573 articles and review articles related to immunotherapy for T1D published from 2004 to 2023 were screened for bibliometric analysis. VOSviewer, CiteSpace, and R software were applied to comprehensively analyze the number of publications, journals, countries, authors, institutions, keywords, and references.

Results: In the past two decades, the global annual publication rate has seen a significant increase of 238.24%. Almost 40% of all publications have appeared in the last 5 years, accounting for over 50% of total citations. Journals such as Diabetes, Journal of Autoimmunity and Frontiers in Immunology have exerted substantial influence. Collaboration across nations has been notably strong, with the United States leading the way. The University of Florida is the most productive institution. Terms like "nivolumab," "ipilimumab," "pembrolizumab," and "immune checkpoint inhibitor(s)" gain considerable traction. The majority of research has clustered around themes such as immunomodulation, autoimmune diseases, immune checkpoint inhibitors, mesenchymal stem cells, and cell therapy. Precision medicine, immune checkpoint inhibitors, and nanotechnology are trending focal points in contemporary research.

Conclusion: The outcomes of the study are instrumental in enabling scholars to comprehend the evolving trajectory of immunotherapeutic approaches for T1D and facilitate the swift recognition of emerging research pathways.

Introduction: Currently, trials are investigating the efficacy of nutrient-stimulated hormone-based therapies (NuSHs) in promoting weight loss in people living with overweight and obesity. However, the extent to which nutritional and functional outcomes are evaluated remains uncertain. Thus, we conducted a systematic mapping to assess the presence of nutritional and functional outcomes in randomized controlled trials (RCTs) investigating NuSHs.

Methods: We conducted a systematic mapping search on the Cochrane Central Register of Controlled Trials (CENTRAL), which includes ClinicalTrials.gov and the International Clinical Trials Registry Platform for interventional trials of NuSHs registered from inception to December 31, 2023. We excluded non- and quasi-randomized trials, phase I trials, trials that did not include body weight as a primary or secondary outcome, trials with an intervention duration of less than 6 months, and trials that did not specify a body mass index threshold in their eligibility criteria. Outcomes included: dietary intake, eating behavior, body composition, physical performance, muscle strength, bone health, and levels of vitamins, trace elements, albumin, prealbumin, and hemoglobin.

Results: The search identified 2284 trials, of which 417 were included in the analysis. The proportion of RCTs that included nutritional assessment other than body weight increased over time. Approximately, 20.4% reported measurements of body composition, 17.3% reported measurements of albumin/prealbumin/hemoglobin, and 17% reported assessment of dietary intake and eating behavior. Evaluations of bone health, physical performance, muscle strength, and measurements of vitamins/trace elements were reported in less than 5% of the total trials each.

Conclusion: The present review has shown the sparse reporting of nutritional and functional outcomes in RCTs evaluating the impact of NuSHs.

Developments in basic stem cell biology have paved the way for technology translation in human medicine. An exciting prospective use of stem cells is the ex vivo generation of hepatic and pancreatic endocrine cells for biomedical applications. This includes creating novel models 'in a dish' and developing therapeutic strategies for complex diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and diabetes. In this review, we explore recent advances in the generation of stem cell-derived hepatocyte-like cells and insulin-producing β-like cells. We cover the different differentiation strategies, new discoveries, and the caveats that still exist regarding their routine use. Finally, we discuss the challenges and limitations of stem cell-derived therapies as a clinical strategy to manage metabolic diseases in humans.