Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100326
M.A. Butt, B. Janaszek, R. Piramidowicz
Integrated optics, a key photonics technology, has major implications for telecommunications, sensing, and computing. By integrating optical elements like lasers, modulators, and detectors onto a single chip, it enhances performance while reducing the size, weight, and power of optical systems. With potential applications in 5G, data centres, quantum communication, and AI, integrated optics is crucial for future communication technologies. Its synergy with quantum information and machine learning opens innovation pathways. This review explores recent advancements in optical platforms, highlighting ongoing research and developments that are driving technological progress in this field. The analysis provides an in-depth scrutiny of recent developments, shedding light on the dynamic terrain of optical innovations and highlighting the strides made in pushing the boundaries of technology.
{"title":"Lighting the way forward: The bright future of photonic integrated circuits","authors":"M.A. Butt, B. Janaszek, R. Piramidowicz","doi":"10.1016/j.sintl.2025.100326","DOIUrl":"10.1016/j.sintl.2025.100326","url":null,"abstract":"<div><div>Integrated optics, a key photonics technology, has major implications for telecommunications, sensing, and computing. By integrating optical elements like lasers, modulators, and detectors onto a single chip, it enhances performance while reducing the size, weight, and power of optical systems. With potential applications in 5G, data centres, quantum communication, and AI, integrated optics is crucial for future communication technologies. Its synergy with quantum information and machine learning opens innovation pathways. This review explores recent advancements in optical platforms, highlighting ongoing research and developments that are driving technological progress in this field. The analysis provides an in-depth scrutiny of recent developments, shedding light on the dynamic terrain of optical innovations and highlighting the strides made in pushing the boundaries of technology.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100326"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100328
Sophia Nazir
Although numerous studies have been conducted on multiple screen-printing electrodes (SPEs), little emphasis has been placed on systematically assessing scholarly work on nanomaterial-equipped SPEs in bioanalytical research. The fabrication of state-of-the-art portable screen-printing measuring devices represents significant disease monitoring and diagnosis advancements. This review classifies screen-printing electrodes based on the nanomaterials used. It discusses cost, regulatory approvals for portable screen-printing electrodes in point-of-care diagnostics, sensitivity, specificity, size reductions, and proposed solutions. It looks into the significance of new nanomaterials and substrates in fabricating point-of-care diagnostic devices and miniaturisation techniques. The review primarily focuses on the recent downsizing advances that have resulted in a growing number of portable screen-printing electrodes for quick point-of-care diagnostics. Special attention is given to identifying different bioanalytics associated with distinct medical problems. Screen-printing biosensors potentially transform healthcare by allowing for rapid, accurate, and individualised diagnosis. These biosensors improve disease management, medical outcomes, and global diagnostic accessibility as technology advances.
{"title":"Advancing point-of-care testing with nanomaterials-based screen-printing electrodes","authors":"Sophia Nazir","doi":"10.1016/j.sintl.2025.100328","DOIUrl":"10.1016/j.sintl.2025.100328","url":null,"abstract":"<div><div>Although numerous studies have been conducted on multiple screen-printing electrodes (SPEs), little emphasis has been placed on systematically assessing scholarly work on nanomaterial-equipped SPEs in bioanalytical research. The fabrication of state-of-the-art portable screen-printing measuring devices represents significant disease monitoring and diagnosis advancements. This review classifies screen-printing electrodes based on the nanomaterials used. It discusses cost, regulatory approvals for portable screen-printing electrodes in point-of-care diagnostics, sensitivity, specificity, size reductions, and proposed solutions. It looks into the significance of new nanomaterials and substrates in fabricating point-of-care diagnostic devices and miniaturisation techniques. The review primarily focuses on the recent downsizing advances that have resulted in a growing number of portable screen-printing electrodes for quick point-of-care diagnostics. Special attention is given to identifying different bioanalytics associated with distinct medical problems. Screen-printing biosensors potentially transform healthcare by allowing for rapid, accurate, and individualised diagnosis. These biosensors improve disease management, medical outcomes, and global diagnostic accessibility as technology advances.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100335
Adilla Chairunisa , Wulan Tri Wahyuni , Irmanida BatuBara , Budi Riza Putra
In this study, a glassy carbon electrode (GCE) was modified with a composite of platinum nanoparticles (PtNPs) and multiwalled carbon nanotubes (MWCNTs) to serve as a sensing platform for the simultaneous detection of hydroquinone (HQ) and methylparaben (MP). The GCE surface was modified using a simple drop-casting technique with a PtNPs/MWCNT composite, and the composite was subsequently characterized by UV–Vis and FTIR spectroscopy, XRD, FESEM-EDS, and TEM techniques. The highest sensitivity of the developed sensor was achieved when the optimum composition of PtNPs and MWCNT was 4:6 on the surface of the GCE. This phenomenon may be attributed to the synergistic interaction between PtNPs and MWCNTs, which enhances the conductivity of the modified electrodes. The synergistic effect in relation to the catalytic activity of PtNPs and the large electroactive surface area of MWCNT results in an enhanced electrocatalytic signal for sensing purposes. Concurrently, the analytical performance of PtNPs/MWCNT/GCE was investigated using the differential pulse voltammetry (DPV) technique, which showed a linear response for HQ and MP in the ranges of 5–200 μM and 50–500 μM, respectively. Moreover, this proposed sensor demonstrated a low limit of detection and good sensitivity for the simultaneous detection of HQ (0.4 μM and 1.8136 μA μM−1 cm−2) and MP (0.8 μM and 0.7076 μA μM−1 cm−2). Furthermore, the proposed sensor exhibited excellent stability, reproducibility, and good selectivity, with recovery values ranging from 97.9 % to 101.6 % for HQ and from 98.8 % to 103.3 % for MP. Thus, this proposed sensor has been applied for the simultaneous detection of HQ and MP in cosmetic products, showing good recovery values that emphasize its potential as a promising sensing platform for detecting contaminant compounds in cosmetic products.
{"title":"A composite of platinum nanoparticles and multiwalled carbon nanotubes modified electrode for sensitive and simultaneous detection of hydroquinone and methylparaben in cosmetic products","authors":"Adilla Chairunisa , Wulan Tri Wahyuni , Irmanida BatuBara , Budi Riza Putra","doi":"10.1016/j.sintl.2025.100335","DOIUrl":"10.1016/j.sintl.2025.100335","url":null,"abstract":"<div><div>In this study, a glassy carbon electrode (GCE) was modified with a composite of platinum nanoparticles (PtNPs) and multiwalled carbon nanotubes (MWCNTs) to serve as a sensing platform for the simultaneous detection of hydroquinone (HQ) and methylparaben (MP). The GCE surface was modified using a simple drop-casting technique with a PtNPs/MWCNT composite, and the composite was subsequently characterized by UV–Vis and FTIR spectroscopy, XRD, FESEM-EDS, and TEM techniques. The highest sensitivity of the developed sensor was achieved when the optimum composition of PtNPs and MWCNT was 4:6 on the surface of the GCE. This phenomenon may be attributed to the synergistic interaction between PtNPs and MWCNTs, which enhances the conductivity of the modified electrodes. The synergistic effect in relation to the catalytic activity of PtNPs and the large electroactive surface area of MWCNT results in an enhanced electrocatalytic signal for sensing purposes. Concurrently, the analytical performance of PtNPs/MWCNT/GCE was investigated using the differential pulse voltammetry (DPV) technique, which showed a linear response for HQ and MP in the ranges of 5–200 μM and 50–500 μM, respectively. Moreover, this proposed sensor demonstrated a low limit of detection and good sensitivity for the simultaneous detection of HQ (0.4 μM and 1.8136 μA μM<sup>−1</sup> cm<sup>−2</sup>) and MP (0.8 μM and 0.7076 μA μM<sup>−1</sup> cm<sup>−2</sup>). Furthermore, the proposed sensor exhibited excellent stability, reproducibility, and good selectivity, with recovery values ranging from 97.9 % to 101.6 % for HQ and from 98.8 % to 103.3 % for MP. Thus, this proposed sensor has been applied for the simultaneous detection of HQ and MP in cosmetic products, showing good recovery values that emphasize its potential as a promising sensing platform for detecting contaminant compounds in cosmetic products.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two novel fluorescent probes (2QAD and 6QAD) for metal ion detection were designed and synthesized based on acetamidoquinoline derivatives containing dipicolylamine unit. 2QAD distinctively exhibits fluorescence enhancement with Cd2+ and Zn2+ in aqueous media at different emission wavelengths of 350 and 380 nm, respectively. The fluorescence enhancement of 2QAD involves inhibiting the PET process from the dipicolylamine group to the quinoline ring by the corresponding 1:1 complexation with each metal ion. The reversibility of complexes when adding EDTA indicates the static fluorescence-enhancing mechanism. The distinguished fluorescence responses result from amide-imidic tautomerization of 2QAD induced by the complexation with different metal ions, confirmed by 1H NMR. From the results of fluorescence titration, the LOD values for Cd2+ and Zn2+ were calculated to be 17 and 8.5 ppb, respectively, with a good linear range. Furthermore, the 2QAD probe can be employed to determine the amount of Cd2+ and Zn2+ in real water samples and can also be applied to macrophage cell RAW264.7.
{"title":"A dual sensing probe for Cd2+ and Zn2+ detection in water based on tautomerization of acetamidoquinoline containing dipicolylamine and its application in water samples and cell imaging","authors":"Waroton Paisuwan , Takuya Kodama , Tanapat Palaga , Thitiporn Pattarakankul , Mongkol Sukwattanasinitt , Nantanat Chailanggar , Mamoru Tobisu , Anawat Ajavakom","doi":"10.1016/j.sintl.2025.100336","DOIUrl":"10.1016/j.sintl.2025.100336","url":null,"abstract":"<div><div>Two novel fluorescent probes (<strong>2QAD</strong> and <strong>6QAD</strong>) for metal ion detection were designed and synthesized based on acetamidoquinoline derivatives containing dipicolylamine unit. <strong>2QAD</strong> distinctively exhibits fluorescence enhancement with Cd<sup>2+</sup> and Zn<sup>2+</sup> in aqueous media at different emission wavelengths of 350 and 380 nm, respectively. The fluorescence enhancement of <strong>2QAD</strong> involves inhibiting the PET process from the dipicolylamine group to the quinoline ring by the corresponding 1:1 complexation with each metal ion. The reversibility of complexes when adding EDTA indicates the static fluorescence-enhancing mechanism. The distinguished fluorescence responses result from amide-imidic tautomerization of <strong>2QAD</strong> induced by the complexation with different metal ions, confirmed by <sup>1</sup>H NMR. From the results of fluorescence titration, the LOD values for Cd<sup>2+</sup> and Zn<sup>2+</sup> were calculated to be 17 and 8.5 ppb, respectively, with a good linear range. Furthermore, the <strong>2QAD</strong> probe can be employed to determine the amount of Cd<sup>2+</sup> and Zn<sup>2+</sup> in real water samples and can also be applied to macrophage cell RAW264.7.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/S2666-3511(25)00040-3
{"title":"Thank you Note for Reviewers","authors":"","doi":"10.1016/S2666-3511(25)00040-3","DOIUrl":"10.1016/S2666-3511(25)00040-3","url":null,"abstract":"","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100365"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100341
Yang Tian , Lisa Kelso , Yiting Xiao , Chaitanya Pallerla , Ramesh Bist , Siavash Mahmoudi , Ziyu Liu , Haizheng Xiong , Jeyam Subbiah , Terry Howell , Dongyi Wang
Rapid and accurate detection of Escherichia coli O157:H7 is essential for ensuring public health, food safety, and environmental monitoring. Traditional detection methods are often time-consuming and require specialized laboratory infrastructure, limiting their practicality for on-site applications. In this study, we present a palm-sized, wireless piezoelectric immunosensor system designed for the swift and sensitive detection of E. coli O157:H7. The system integrates a gold-coated quartz crystal microbalance (QCM) sensor functionalized with protein A-immobilized antibodies, a polydimethylsiloxane (PDMS) microfluidic channel for efficient sample handling, and a flexible loop antenna for wireless signal transmission. Real-time data is transmitted via Bluetooth to a smartphone application, enhancing user interaction and portability. Sensitivity tests demonstrated a proportional increase in frequency shift corresponding to E. coli O157:H7 concentrations, achieving a detection limit as low as 102 CFU ml−1 in field samples. Selectivity tests confirmed minimal cross-reactivity with other bacteria, highlighting the sensor's specificity. The incorporation of immuno-nanobeads amplified the signal, enhancing the system's ability to detect low bacterial concentrations. The portable, self-powered system offers a practical solution for rapid, on-site pathogen detection, addressing critical needs in food safety and environmental monitoring. By enabling timely and accurate detection of contaminants, this technology has the potential to significantly impact public health by reducing the incidence of foodborne illnesses, safeguarding environmental resources, and enhancing overall safety and health outcomes.
{"title":"Palm-size wireless piezoelectric immune-biosensing system for rapid E. coli O157:H7 detection","authors":"Yang Tian , Lisa Kelso , Yiting Xiao , Chaitanya Pallerla , Ramesh Bist , Siavash Mahmoudi , Ziyu Liu , Haizheng Xiong , Jeyam Subbiah , Terry Howell , Dongyi Wang","doi":"10.1016/j.sintl.2025.100341","DOIUrl":"10.1016/j.sintl.2025.100341","url":null,"abstract":"<div><div>Rapid and accurate detection of <em>Escherichia coli O157:H7</em> is essential for ensuring public health, food safety, and environmental monitoring. Traditional detection methods are often time-consuming and require specialized laboratory infrastructure, limiting their practicality for on-site applications. In this study, we present a palm-sized, wireless piezoelectric immunosensor system designed for the swift and sensitive detection of <em>E. coli O157:H7</em>. The system integrates a gold-coated quartz crystal microbalance (QCM) sensor functionalized with protein A-immobilized antibodies, a polydimethylsiloxane (PDMS) microfluidic channel for efficient sample handling, and a flexible loop antenna for wireless signal transmission. Real-time data is transmitted via Bluetooth to a smartphone application, enhancing user interaction and portability. Sensitivity tests demonstrated a proportional increase in frequency shift corresponding to <em>E. coli O157:H7</em> concentrations, achieving a detection limit as low as 10<sup>2</sup> CFU ml<sup>−1</sup> in field samples. Selectivity tests confirmed minimal cross-reactivity with other bacteria, highlighting the sensor's specificity. The incorporation of immuno-nanobeads amplified the signal, enhancing the system's ability to detect low bacterial concentrations. The portable, self-powered system offers a practical solution for rapid, on-site pathogen detection, addressing critical needs in food safety and environmental monitoring. By enabling timely and accurate detection of contaminants, this technology has the potential to significantly impact public health by reducing the incidence of foodborne illnesses, safeguarding environmental resources, and enhancing overall safety and health outcomes.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100332
Fatma Ozturk Kirbay , İdris Yazgan , Dilek Odaci
D-dimer (DD) is a key marker of coagulation and fibrinolysis activation. Clinicians can make important decisions with the aid of quick analysis and quantification, ideally at the patient's bedside. Electrochemical immunosensors are effective point-of-care technologies to address these issues. Here, we describe the development of a simple electrochemical immunosensor to detect DD. The immunosensor is constructed by electrodeposition of lactose methoxide aniline silver nanoparticles (LMA-AgNPs) on a screen-printed carbon electrode (SPCE). The LMA-AgNP and SPCE/LMA-AgNP were characterized by Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS), and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of the SPCE/LMA-AgNP was examined using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). Then, Anti-D-Dimer antibody (Anti-DD) was immobilized on SPCE/LMA-AgNP. Along with the analytical characterization of the SPCE/LMA-AgNP/Anti-DD immunosensor, the linear range for DD, limit of detection (LOD), potential chemical interferences, and real sample applications were also evaluated. The antigen/antibody interaction at various DD concentrations was monitored using DPV. The SPCE/LMA-AgNP/Anti-DD shows a linear response in the DD concentration range of 0.01–1 pg/mL and a LOD of 0.2 fg/mL. In addition, the SPCE/LMA-AgNP/Anti-DD showed excellent specificity and no response to potential interfering substances, for instance urea, insulin, C-reactive protein (CRP), and serum amyloid A (SAA). Eventually, the SPCE/LMA-AgNP/Anti-DD is applied in human serum, which shows good recovery values (97.2 %). The SPCE/LMA-AgNP/Anti-DD can be fabricated cheaply and easily for bedside clinical evaluation.
d -二聚体（DD）是凝血和纤溶激活的关键标志物。临床医生可以在快速分析和量化的帮助下做出重要的决定，最好是在病人的床边。电化学免疫传感器是解决这些问题的有效护理点技术。本文描述了一种简单的用于检测DD的电化学免疫传感器的开发。该免疫传感器是通过在丝网印刷碳电极（SPCE）上电沉积乳糖甲氧基苯胺银纳米粒子（LMA-AgNPs）构建的。采用傅里叶变换红外光谱（FTIR）、高分辨率透射电子显微镜（HR-TEM）、扫描电子显微镜-能量色散x射线能谱（SEM-EDS）和x射线光电子能谱（XPS）对LMA-AgNP和SPCE/LMA-AgNP进行表征。采用电化学阻抗谱（EIS）、差分脉冲伏安法（DPV）和循环伏安法（CV）对SPCE/LMA-AgNP的电化学行为进行了表征。然后，将anti - d -二聚体抗体（Anti-DD）固定在SPCE/LMA-AgNP上。随着SPCE/LMA-AgNP/Anti-DD免疫传感器的分析表征，DD的线性范围，检测限（LOD），潜在的化学干扰和实际样品应用也进行了评估。采用DPV法监测不同DD浓度下抗原/抗体相互作用。SPCE/LMA-AgNP/Anti-DD在0.01-1 pg/mL的浓度范围内呈线性响应，LOD为0.2 fg/mL。此外，SPCE/LMA-AgNP/Anti-DD对尿素、胰岛素、c反应蛋白（CRP）、血清淀粉样蛋白A （SAA）等潜在干扰物质均无反应，具有良好的特异性。最终将SPCE/LMA-AgNP/Anti-DD应用于人血清，回收率为97.2%。SPCE/LMA-AgNP/Anti-DD制备成本低，易于临床评价。
{"title":"Development of a sugar-derived silver nanoparticle-based electrochemical immunosensor for sensitive D-dimer detection","authors":"Fatma Ozturk Kirbay , İdris Yazgan , Dilek Odaci","doi":"10.1016/j.sintl.2025.100332","DOIUrl":"10.1016/j.sintl.2025.100332","url":null,"abstract":"<div><div>D-dimer (DD) is a key marker of coagulation and fibrinolysis activation. Clinicians can make important decisions with the aid of quick analysis and quantification, ideally at the patient's bedside. Electrochemical immunosensors are effective point-of-care technologies to address these issues. Here, we describe the development of a simple electrochemical immunosensor to detect DD. The immunosensor is constructed by electrodeposition of lactose methoxide aniline silver nanoparticles (LMA-AgNPs) on a screen-printed carbon electrode (SPCE). The LMA-AgNP and SPCE/LMA-AgNP were characterized by Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS), and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of the SPCE/LMA-AgNP was examined using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). Then, Anti-D-Dimer antibody (Anti-DD) was immobilized on SPCE/LMA-AgNP. Along with the analytical characterization of the SPCE/LMA-AgNP/Anti-DD immunosensor, the linear range for DD, limit of detection (LOD), potential chemical interferences, and real sample applications were also evaluated. The antigen/antibody interaction at various DD concentrations was monitored using DPV. The SPCE/LMA-AgNP/Anti-DD shows a linear response in the DD concentration range of 0.01–1 pg/mL and a LOD of 0.2 fg/mL. In addition, the SPCE/LMA-AgNP/Anti-DD showed excellent specificity and no response to potential interfering substances, for instance urea, insulin, C-reactive protein (CRP), and serum amyloid A (SAA). Eventually, the SPCE/LMA-AgNP/Anti-DD is applied in human serum, which shows good recovery values (97.2 %). The SPCE/LMA-AgNP/Anti-DD can be fabricated cheaply and easily for bedside clinical evaluation.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100331
Neng Astri Lidiawati , Muhammad Fadlan Raihan , Angga Hermawan , Octia Floweri , Robeth Viktoria Manurung , Muhammad Iqbal , Ahmad Nuruddin , Nugraha , Brian Yuliarto , Ni Luh Wulan Septiani
An electrochemical immunosensor was developed using a modified metal-organic framework (MOF) for detecting dengue virus serotype 3 (DENV-3) NS1. CuNi-MOF frameworks with varying Cu:Ni molar ratios—1:0 (CuNi-1), 5:1 (CuNi-2), 3:1 (CuNi-3), and 1:1 (CuNi-4)—were synthesized, incorporating 10 wt% triethanolamine (TEOA) as a modulator to enhance performance. X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectra confirm the successful formation of CuNi-MOF. Morphological evolution was observed as the Ni content increased to 50 % (CuNi-4), resulting in a transformation from octahedral to bar-like particles. Among the synthesized materials, CuNi-4 exhibited the highest redox current, making it the optimal choice for electrochemical measurements targeting dengue virus (DENV) detection. Using DPV technique, it was found that linear range of DENV-3 antigen concentration is 0.001 ng mL−1 - 5 ng mL−1 with a limit of detection (LoD) of 0.1 pg mL−1. In addition, the CuNi-4 exhibited remarkable selectivity for DENV-3 over the other three dengue virus serotypes. Real sample testing using DENV-3 antigen with variation concentration of 0.001; 0.01; 0.1; 1; and 10 ng mL−1 in commercial human serum resulted in the recovery of 98 %, 94 %, 97 %, 95 %, and 98 %, respectively. The findings highlight the promise of the CuNi-4-based electrochemical immunosensor for detecting NS-1 antigens of DENV-3 with high specificity and sensitivity.
采用改良金属-有机骨架（MOF）研制了一种检测登革热病毒血清型3 (DENV-3) NS1的电化学免疫传感器。分别合成了Cu:Ni摩尔比为1:0 （Cu -1）、5:1 （Cu -2）、3:1 （Cu -3）和1:1 （Cu -4）的Cu - mof框架，并添加了10%的三乙醇胺（TEOA）作为调制剂来提高性能。x射线衍射（XRD）和傅里叶变换红外光谱（FTIR）证实了cu - mof的成功形成。当Ni含量增加到50% （cu -4）时，观察到形态进化，导致八面体颗粒转变为条状颗粒。在合成的材料中，cu -4表现出最高的氧化还原电流，使其成为针对登革热病毒（DENV）检测的电化学测量的最佳选择。DPV技术检测结果显示，DENV-3抗原浓度线性范围为0.001 ng mL−1 ~ 5 ng mL−1，检出限为0.1 pg mL−1。此外，CuNi-4对DENV-3的选择性优于其他3种登革热病毒血清型。用变异浓度为0.001的DENV-3抗原检测实样；0.01;0.1;1;10 ng mL−1的回收率分别为98%、94%、97%、95%和98%。这些发现突出了基于cu -4的电化学免疫传感器对DENV-3 NS-1抗原的高特异性和高灵敏度检测的前景。
{"title":"Effect of nickel incorporation on the physicochemical properties and performance of HKUST-1-based MOF immunosensor for DENV-3 NS1 detection","authors":"Neng Astri Lidiawati , Muhammad Fadlan Raihan , Angga Hermawan , Octia Floweri , Robeth Viktoria Manurung , Muhammad Iqbal , Ahmad Nuruddin , Nugraha , Brian Yuliarto , Ni Luh Wulan Septiani","doi":"10.1016/j.sintl.2025.100331","DOIUrl":"10.1016/j.sintl.2025.100331","url":null,"abstract":"<div><div>An electrochemical immunosensor was developed using a modified metal-organic framework (MOF) for detecting dengue virus serotype 3 (DENV-3) NS1. CuNi-MOF frameworks with varying Cu:Ni molar ratios—1:0 (CuNi-1), 5:1 (CuNi-2), 3:1 (CuNi-3), and 1:1 (CuNi-4)—were synthesized, incorporating 10 wt% triethanolamine (TEOA) as a modulator to enhance performance. X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectra confirm the successful formation of CuNi-MOF. Morphological evolution was observed as the Ni content increased to 50 % (CuNi-4), resulting in a transformation from octahedral to bar-like particles. Among the synthesized materials, CuNi-4 exhibited the highest redox current, making it the optimal choice for electrochemical measurements targeting dengue virus (DENV) detection. Using DPV technique, it was found that linear range of DENV-3 antigen concentration is 0.001 ng mL<sup>−1</sup> - 5 ng mL<sup>−1</sup> with a limit of detection (LoD) of 0.1 pg mL<sup>−1</sup>. In addition, the CuNi-4 exhibited remarkable selectivity for DENV-3 over the other three dengue virus serotypes. Real sample testing using DENV-3 antigen with variation concentration of 0.001; 0.01; 0.1; 1; and 10 ng mL<sup>−</sup><sup>1</sup> in commercial human serum resulted in the recovery of 98 %, 94 %, 97 %, 95 %, and 98 %, respectively. The findings highlight the promise of the CuNi-4-based electrochemical immunosensor for detecting NS-1 antigens of DENV-3 with high specificity and sensitivity.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100331"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100337
Artem Eliseev , Vladimir Korolev , Evgeny Anokhin , Andrei Chumakov , Alexander Vasiliev , Lev Trusov , Pavel Kazin , Andrei Eliseev
The paper reports on the application of hard magnetic nanoplatelets for direct local dynamic viscosity evaluation in liquids through their drag-hindered rotation after a magnetic field. Strontium hexaferrite, SrFe12O19 nanoplatelets with a diameter of 50 nm and a thickness of 5 nm were employed as nanoscale probes. The dynamics of nanoplatelets is investigated with AC magnetometry, small-angle X-ray scattering, and optical absorption/reflectance spectroscopy. Those reveal well-defined relation of drag force and phase lag tangent for platelets rotation under AC magnetization with the viscosity of the medium. The analytical quantitative description for magneto-optical response is provided and utilized successfully for independent viscosity evaluation of various liquids within the viscosity range of 0.5–1000 mPa∙s. The nanoscale size of the probes also enabled viscosity visualization with micrometer resolution in microchannels.
{"title":"Fast micrometer resolution magneto-optical viscosity measurements with hard magnetic nanoplatelets","authors":"Artem Eliseev , Vladimir Korolev , Evgeny Anokhin , Andrei Chumakov , Alexander Vasiliev , Lev Trusov , Pavel Kazin , Andrei Eliseev","doi":"10.1016/j.sintl.2025.100337","DOIUrl":"10.1016/j.sintl.2025.100337","url":null,"abstract":"<div><div>The paper reports on the application of hard magnetic nanoplatelets for direct local dynamic viscosity evaluation in liquids through their drag-hindered rotation after a magnetic field. Strontium hexaferrite, SrFe<sub>12</sub>O<sub>19</sub> nanoplatelets with a diameter of 50 nm and a thickness of 5 nm were employed as nanoscale probes. The dynamics of nanoplatelets is investigated with AC magnetometry, small-angle X-ray scattering, and optical absorption/reflectance spectroscopy. Those reveal well-defined relation of drag force and phase lag tangent for platelets rotation under AC magnetization with the viscosity of the medium. The analytical quantitative description for magneto-optical response is provided and utilized successfully for independent viscosity evaluation of various liquids within the viscosity range of 0.5–1000 mPa∙s. The nanoscale size of the probes also enabled viscosity visualization with micrometer resolution in microchannels.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.sintl.2025.100334
Alaa Hussein Hilal, Ahmed Hameed Reja, Mohammed J. Mohammed
In the last decade, the number of drones has been increasing and becoming cheaper relative to the damage they can cause, threatening airports, transportation, and military applications. Jamming on drones is becoming more and more significant. Handheld anti-drone jammer antennas require high-gain directivity beam patterns with narrow half-power beam widths (HPBW) while also covering multiple frequency bands that are used by drones. This work has modified the proposed multiband gain and enhanced the narrow beam utilized by the Dual Ridge Horn Antenna (DRHA) to meet the requirements of drone jamming systems. The proposed antenna can cover GPS , 2.45 GHz, and 5.8 GHz. This work presents a DRHA developed utilizing CST Studio and optimized by using genetic algorithm optimization (GA) that has been employed to improve parameters that enhance selected frequencies. One of the standout features of this design is the incorporation of a dielectric microwave lens, which significantly improved the antenna factor This lens has been inventively crafted using three dielectric constant, 2.1, 4, and 4.2 at three different diameters 11 cm, 7 cm and 4 cm as well as different thickness 0.9 cm, 1.3 cm and 1.5 cm, respectively. According to impressive simulations the reflection coefficient has been improved from dB to an incredible dB at 2.45 GHz. Regarding to the Vector Network Analyzer (VNA) outcomes the practical design improved from dB to dB which reflecting a remarkable enhancement of 43.88% after integrating the dielectric lens. The final dimensions of the fabricated antenna, including the feed section, have been defined as (3.65 ), aligning excellently with relevant works. Finally, the practical design is an agreement match with simulation results, and the measured peak gain is 7.92 dB at 1.575 GHz, 10.9 dB at 2.45 GHz and 15 dB at 5.8 GHz. The proposed antenna would be suitable for use in a portable handheld jamming system on drones.
{"title":"Modify a dual ridge horn antenna for drone jamming applications","authors":"Alaa Hussein Hilal, Ahmed Hameed Reja, Mohammed J. Mohammed","doi":"10.1016/j.sintl.2025.100334","DOIUrl":"10.1016/j.sintl.2025.100334","url":null,"abstract":"<div><div>In the last decade, the number of drones has been increasing and becoming cheaper relative to the damage they can cause, threatening airports, transportation, and military applications. Jamming on drones is becoming more and more significant. Handheld anti-drone jammer antennas require high-gain directivity beam patterns with narrow half-power beam widths (HPBW) while also covering multiple frequency bands that are used by drones. This work has modified the proposed multiband gain and enhanced the narrow beam utilized by the Dual Ridge Horn Antenna (DRHA) to meet the requirements of drone jamming systems. The proposed antenna can cover GPS <span><math><msub><mrow><mi>L</mi></mrow><mrow><mn>1</mn></mrow></msub></math></span>, 2.45 GHz, and 5.8 GHz. This work presents a DRHA developed utilizing CST Studio and optimized by using genetic algorithm optimization (GA) that has been employed to improve parameters that enhance selected frequencies. One of the standout features of this design is the incorporation of a dielectric microwave lens, which significantly improved the antenna factor This lens has been inventively crafted using three dielectric constant, <span><math><msub><mrow><mi>ɛ</mi></mrow><mrow><mi>r</mi></mrow></msub></math></span> 2.1, 4, and 4.2 at three different diameters 11 cm, 7 cm and 4 cm as well as different thickness 0.9 cm, 1.3 cm and 1.5 cm, respectively. According to impressive simulations the reflection coefficient has been improved from <span><math><mrow><mo>−</mo><mn>12</mn><mo>.</mo><mn>13</mn></mrow></math></span> dB to an incredible <span><math><mrow><mo>−</mo><mn>19</mn><mo>.</mo><mn>7</mn></mrow></math></span> dB at 2.45 GHz. Regarding to the Vector Network Analyzer (VNA) outcomes the practical design improved from <span><math><mrow><mo>−</mo><mn>8</mn><mo>.</mo><mn>25</mn></mrow></math></span> dB to <span><math><mrow><mo>−</mo><mn>18</mn><mo>.</mo><mn>8</mn></mrow></math></span> dB which reflecting a remarkable enhancement of 43.88% after integrating the dielectric lens. The final dimensions of the fabricated antenna, including the feed section, have been defined as (3.65<span><math><mi>λ</mi></math></span> <span><math><mrow><mo>×</mo><mn>2</mn><mi>λ</mi></mrow></math></span> <span><math><mrow><mo>×</mo><mn>2</mn><mi>λ</mi></mrow></math></span>), aligning excellently with relevant works. Finally, the practical design is an agreement match with simulation results, and the measured peak gain is 7.92 dB at 1.575 GHz, 10.9 dB at 2.45 GHz and 15 dB at 5.8 GHz. The proposed antenna would be suitable for use in a portable handheld jamming system on drones.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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