Pediatric Obesity最新文献_第3页

Impact of a Home-Based Obesity Prevention Intervention on Children's and Parents' BMI: Findings From the Guelph Family Health Study Randomised Controlled Trial 基于家庭的肥胖预防干预对儿童和父母BMI的影响：来自圭尔夫家庭健康研究随机对照试验的发现

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-10-22 DOI: 10.1111/ijpo.70062

Raphaëlle Jacob, Andrea C. Buchholz, Gerarda Darlington, Alison M. Duncan, Lori Ann Vallis, Jean-Philippe Chaput, Angela Annis, Madeline Nixon, Jennifer D. Irwin, Don Morrow, David W. L. Ma, Jess Haines

Background

To prevent the development of obesity and related comorbidities, interventions must begin early in life. This study aimed to assess the impact of a home-based obesity prevention intervention on children's and parents' body mass index (BMI).

Methods

The Guelph Family Health Study is a randomised controlled trial of a 6-month obesity prevention intervention aimed at establishing healthful household routines regarding family meals, children's screen time, physical activity and sleep among 285 families with preschool-aged children. The control group received 6 emails on child health behaviours. The analytic sample included 376 children (3.6 ± 1.3 years old, 20.2% at risk for overweight, 8.2% with overweight/obesity) and 481 parents (58.2% with overweight/obesity).

Results

Compared to controls, the intervention had no significant impact on children's or parents' BMI at post-intervention and 1 year after the intervention. Children in both the intervention and control groups had a non-significant decrease in BMI from baseline to post-intervention [intervention; −0.23 kg/m² (95% CI, −0.46, 0.002); control; −0.17 kg/m² (95% CI, −0.40, 0.06)] and from baseline to 1-year follow-up [intervention, −0.29 kg/m² (95% CI, −0.67, 0.08); control, −0.06 kg/m² (95% CI, −0.42, 0.30)].

Conclusions

Compared to controls, this home-based obesity prevention intervention had no significant impact on children's or parents' BMI immediately after the intervention or after 1 year of follow-up, indicating that the intervention had no additional effect compared to the control group on children's or parents' BMI over time. Future data collection phases will allow for the examination of the intervention effect on BMI as children age.

Trial Registration

This study is registered at clinicaltrial.gov identifier: NCT02939261

背景：为了预防肥胖和相关合并症的发展，干预措施必须在生命早期开始。本研究旨在评估以家庭为基础的肥胖预防干预对儿童和父母体重指数（BMI）的影响。方法：圭尔夫家庭健康研究是一项为期6个月的肥胖预防干预的随机对照试验，目的是在285个有学龄前儿童的家庭中建立健康的家庭常规，包括家庭膳食、儿童屏幕时间、身体活动和睡眠。对照组收到6封关于儿童健康行为的电子邮件。分析样本包括376名儿童（3.6±1.3岁，20.2%有超重危险，8.2%有超重/肥胖）和481名家长（58.2%有超重/肥胖）。结果：与对照组相比，干预对干预后及干预后1年儿童及家长的BMI均无显著影响。干预组和对照组儿童的BMI从基线到干预后均无显著下降[干预；-0.23 kg/m2 (95% CI, -0.46, 0.002)；控制;-0.17 kg/m2 (95% CI, -0.40, 0.06)]，从基线到1年随访[干预]，-0.29 kg/m2 (95% CI, -0.67, 0.08)；对照组为-0.06 kg/m2 （95% CI, -0.42, 0.30）。结论：与对照组相比，这种以家庭为基础的肥胖预防干预在干预后立即或随访1年后对儿童或父母的BMI没有显著影响，这表明与对照组相比，干预对儿童或父母的BMI没有额外的影响。未来的数据收集阶段将允许检查干预对儿童年龄BMI的影响。试验注册：本研究在clinicaltrial.gov注册，识别码：NCT02939261。

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引用次数: 0

Role of Sleep Duration and Timing on Paediatric BMI Across Childhood and Adolescence: Do Both Matter? 睡眠时间和睡眠时间对儿童和青少年BMI的影响：两者都重要吗？

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-10-21 DOI: 10.1111/ijpo.70064

Yundan Zhang, Joyce M. Lee, Karen E. Peterson, Jonathan A. Mitchell, Erica C. Jansen

Background

Adequate sleep duration is a prevention factor for paediatric obesity, but the role of timing is still unclear.

Objectives

To investigate associations of sleep duration and timing with BMI in a large paediatric database.

Methods

Medical chart and survey data were collected from 29 409 children aged 2–18 years who attended well-child visits between Jan 2019 and Dec 2023 (repeated-measures cross-sectional design). Logistic and linear mixed effects regression models accounting for repeated measures estimated odds of overweight/obesity and continuous BMI-for-age CDC-based percentiles for each additional/later hour of sleep duration, midpoint (median of bedtime and wake time), and bedtime, adjusted for potential confounders and stratified by age groups.

Results

Among young children (2–5 years), shorter sleep duration but not sleep timing was related to higher odds of overweight/obesity (21% higher odds with 95% CI: 3% to 36%). In mid-childhood (6–12 years), shorter sleep duration and later midpoint were associated with higher odds of overweight/obesity (18%, 95% CI = 9%, 26%; 32%, 95% CI = 17%, 49%). Among adolescents (13–18 years), each hour of later sleep midpoint equated to 12% higher odds of living with overweight/obesity (95% CI: 1% to 23%). Linear models were similar.

Conclusions

Shorter sleep duration at younger ages and later sleep timing in adolescence were associated with higher BMI.

背景：充足的睡眠时间是预防儿童肥胖的一个因素，但时间的作用尚不清楚。目的：在一个大型儿科数据库中调查睡眠时间和睡眠时间与BMI的关系。方法：收集2019年1月至2023年12月就诊的29 409名2-18岁儿童的病历和调查数据（重复测量横断面设计）。考虑重复测量的Logistic和线性混合效应回归模型估计了超重/肥胖的几率和基于疾病预防控制中心的连续bmi年龄百分位数，每增加/晚睡一小时，中点（就寝时间和清醒时间的中位数）和就寝时间，调整了潜在的混杂因素并按年龄组分层。结果：在幼儿（2-5岁）中，较短的睡眠时间而非睡眠时间与较高的超重/肥胖几率相关（高21%的几率，95% CI: 3%至36%）。在儿童中期（6-12岁），较短的睡眠时间和较晚的睡眠时间与较高的超重/肥胖几率相关（18%,95% CI = 9%, 26%; 32%, 95% CI = 17%, 49%）。在青少年（13-18岁）中，睡眠中点每晚一个小时，超重/肥胖的几率就会增加12%（95%置信区间：1%至23%）。线性模型相似。结论：年轻时较短的睡眠时间和青春期较晚的睡眠时间与较高的BMI有关。

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引用次数: 0

First 1000 Days Strategies to Prevent Childhood Obesity: A Narrative Review and Recommendations From the EndObesity Consortium 预防儿童肥胖的前1000天策略：来自肥胖联盟的叙述回顾和建议。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-10-17 DOI: 10.1111/ijpo.70060

Mireille C. Schipper, Anna Manshanden, Kaat Philippe, Natàlia Ferré, Veronica Luque, Marion Lecorguillé, Adrien M. Aubert, Kathrin Guerlich, Camille Le Gal, Shweta Feher, Ester Parada-Ricart, Joaquin Escribano, Veit Grote, Berthold Koletzko, Teresa Primavesi-Poggio, Katharina Reiss, Jaap C. Seidell, Sandrine Lioret, Catherine M. Phillips, Barbara Heude, Romy Gaillard

Childhood obesity remains a major global public health challenge, leading to significant short- and long-term adverse health outcomes and imposing substantial societal costs. Recognising the critical importance of early intervention, the Horizon2020 EU-funded JPI Consortium EndObesity has prioritised the first 1000 days of life, from preconception to 2 years of age, as a key window for obesity prevention strategies. This narrative review synthesises findings from the EndObesity Consortium, summarising evidence from large multi-cohort studies on the influence of family-based health behaviours in the first 1000 days on offspring obesity risk, the potential of childhood obesity prediction models in the first 1000 days, and strategies to enhance prenatal and postnatal interventions to prevent childhood obesity development. Finally, we present recommendations for research, practice, and policy to address the complex, multifaceted challenges of childhood obesity prevention in the first 1000 days.

儿童肥胖仍然是一项重大的全球公共卫生挑战，导致严重的短期和长期不良健康后果，并造成巨大的社会成本。意识到早期干预的重要性，欧盟资助的Horizon2020 JPI Consortium endobesobesity将生命的前1000天（从孕前到两岁）作为预防肥胖策略的关键窗口。这篇叙述性综述综合了来自肥胖联盟的研究结果，总结了来自大型多队列研究的证据，这些研究涉及前1000天家庭健康行为对后代肥胖风险的影响，前1000天儿童肥胖预测模型的潜力，以及加强产前和产后干预以预防儿童肥胖发展的策略。最后，我们提出了研究、实践和政策方面的建议，以解决儿童肥胖预防在头1000天面临的复杂、多方面的挑战。

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引用次数: 0

Relative Fat Mass as an Estimator of Abdominal Adiposity in Youth Across the BMI Spectrum from Normal Weight to Obesity 相对脂肪量作为从正常体重到肥胖的BMI谱中青少年腹部肥胖的估计。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-10-15 DOI: 10.1111/ijpo.70059

Wonhee Cho, Joon Young Kim, Silva Arslanian

Background

Relative fat mass (RFM) has been used to estimate whole-body fat percentage (%BF). However, whether RFM can mirror abdominal adiposity is unknown.

Objective

In youth, we examined if RFM reflects abdominal adiposity, if there are age/race/sex differences in the relationships between RFM and abdominal adiposity, and if our present-youth-cohort-derived RFM (RFM-Y) improves the prediction of %BF and abdominal adiposity.

Methods

In 358 youth (aged 10–19 years; 168 black/198 white) with normal weight and overweight/obesity (without secondary or syndromic obesity), visceral (VAT), subcutaneous (SAT) and total abdominal adipose tissue (TAT) were assessed by MRI/CT and %BF with DXA. RFM was calculated for ages 10–14 years as [74 − (22 × height/waist circumference [WC]) + (5 × sex)] and 15–19 years as [64 − (20 × height/WC) + (12 × sex)]; sex = 0 for boys, 1 for girls. To develop and validate RFM-Y, linear regression, concordance correlation coefficient, Bland–Altman plots and intraclass correlation coefficient were conducted.

Results

RFM associated with VAT, SAT and TAT (r = 0.66, 0.79, 0.79, respectively; all p < 0.001). The slope was significantly greater in (a) younger versus older youth for VAT, SAT and TAT; (b) whites versus blacks for VAT; and (c) girls versus boys for SAT and TAT. RFM-Y versus traditional RFM showed improved predictive ability for %BF (R ² = 0.83 vs. 0.77) and abdominal adiposity (R ² ranging from 0.51 to 0.80 vs. 0.37 to 0.63).

Conclusions

RFM reflects abdominal adiposity besides %BF and could be used in longitudinal/interventional youth trials, obviating the need for expensive imaging to assess changes in total and abdominal adiposity.

背景：相对脂肪量（RFM）已被用来估计全身脂肪百分比（%BF）。然而，RFM是否能反映腹部肥胖尚不清楚。目的：在年轻人中，我们研究了RFM是否反映了腹部肥胖，RFM和腹部肥胖之间的关系是否存在年龄/种族/性别差异，以及我们现在的青年队列衍生的RFM （RFM- y）是否改善了BF %和腹部肥胖的预测。方法：对358例体重正常、超重/肥胖（无继发性或综合征性肥胖）的青年（10-19岁；黑人168例/白人198例），采用MRI/CT和%BF结合DXA对内脏（VAT）、皮下（SAT）和腹部总脂肪组织（TAT）进行评估。10-14岁的RFM为[74 - (22 ×身高/腰围[WC]) + （5 ×性别）]，15-19岁的RFM为[64 - （20 ×身高/腰围）+ （12 ×性别）]；性别=男孩0，女孩1。采用线性回归、一致性相关系数、Bland-Altman图和类内相关系数等方法对RFM-Y进行开发和验证。结果：RFM与VAT、SAT和TAT （r分别为0.66、0.79、0.79；p均为0.83 vs. 0.77）和腹部肥胖相关（R2为0.51 ~ 0.80 vs. 0.37 ~ 0.63）。结论：RFM除反映BF %外还反映腹部脂肪，可用于纵向/介入性青年试验，无需昂贵的成像来评估总脂肪和腹部脂肪的变化。

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引用次数: 0

Priority Populations in Early Childhood Obesity Prevention Interventions: A Scoping Review 儿童早期肥胖预防干预的重点人群：范围综述。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-10-15 DOI: 10.1111/ijpo.70058

Talia Palacios, Kylie E. Hunter, Brittany J. Johnson, Sol Libesman, Nipun Shrestha, H. Shonna Yin, Jonathan G. Williams, Anna Lene Seidler

Background

Childhood obesity disproportionately affects priority populations, including racial and ethnic minority groups and those with lower socio-economic backgrounds. These groups often encounter barriers to accessing public health services and may benefit from targeted interventions.

Objective

This scoping review aimed to identify the characteristics of populations involved in interventions to prevent early childhood obesity and to understand whether and how existing interventions targeted and reached priority populations.

Methods

Databases and trial registries were systematically searched until 4 October 2024, for planned, ongoing, and completed randomised controlled trials evaluating parent-focussed, behavioural interventions for childhood obesity prevention, starting within the first year of life. Two reviewers independently extracted data using a customised tool.

Results

Of the 11 960 articles identified, 82 trials were eligible. Most trials (87%) were conducted (or planned) in high-income countries, 11% in upper middle-income countries, and 2% in lower middle-income countries. Priority populations included parent–child dyads from specific ethnic or racial groups facing psychological, social, and/or economic disadvantages. Among the completed trials, 54% targeted priority populations, yet only 33% exclusively enrolled participants from these groups. Additionally, less than a quarter of the trials involved priority populations in the design of interventions (17%) and developed tailored interventions for these groups (21%).

Conclusions

Current interventions do not sufficiently target, reach and engage priority populations. To achieve health equity in early childhood obesity prevention, it is essential to include underserved and at-risk populations in research and intervention design.

背景：儿童肥胖不成比例地影响重点人群，包括种族和少数民族群体以及社会经济背景较低的人群。这些群体在获得公共卫生服务方面经常遇到障碍，并可能受益于有针对性的干预措施。目的：本综述旨在确定参与预防早期儿童肥胖干预措施的人群特征，并了解现有干预措施是否以及如何针对并达到重点人群。方法：系统检索数据库和试验注册库，直至2024年10月4日，以评估以父母为中心的儿童肥胖预防行为干预的随机对照试验，从生命的第一年开始，评估正在进行和完成的随机对照试验。两名审稿人使用定制的工具独立提取数据。结果：在11960篇文献中，有82项试验符合条件。大多数试验（87%）在高收入国家进行（或计划进行），11%在中高收入国家，2%在中低收入国家。重点人群包括来自面临心理、社会和/或经济劣势的特定族裔或种族群体的亲子二人组。在已完成的试验中，54%针对的是优先人群，但只有33%的试验只招募了这些人群的参与者。此外，不到四分之一的试验在干预措施设计中涉及优先人群（17%），并为这些群体制定了量身定制的干预措施（21%）。结论：目前的干预措施没有充分瞄准、覆盖和吸引重点人群。为了在儿童早期肥胖预防方面实现健康公平，必须在研究和干预设计中纳入服务不足和高危人群。

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引用次数: 0

Unveiling the Association Between Emotional Eating and Psychosocial Health in Spanish Adolescents: The EHDLA Study 揭示西班牙青少年情绪化饮食与心理社会健康之间的关系：EHDLA研究。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-09-15 DOI: 10.1111/ijpo.70056

Lina América Sánchez-Charcopa, Caroline Brand, Camila Felin Fochesatto, Rodrigo Yáñez-Sepúlveda, Hector Gutiérrez-Espinoza, Jorge Olivares-Arancibia, Josefa María Panisello Royo, Brendon Stubbs, Lee Smith, José Francisco López-Gil

Emotional eating has been associated with several adverse health outcomes, yet research examining its relationship with psychosocial health among adolescents remains limited. The objective of the study was to investigate the association between emotional eating and psychosocial health in Spanish adolescents. Cross-sectional data were collected from 633 participants (56.9% female) aged 12–17 years from all three secondary schools in the Valle de Ricote (Spain), as part of the Eating Healthy and Daily Life Activities (EHDLA) study. Emotional eating was assessed using the Emotional Eating Scale Adapted for Use in Children and Adolescents (EES-C), while psychosocial health was measured using the Strengths and Difficulties Questionnaire (SDQ). To explore the relationship between emotional eating and psychosocial health, generalised linear models (GLMs) were applied. Results revealed significant associations between higher levels of overall emotional eating (unstandardized beta coefficient [B] = 0.04, 95% confidence interval [CI] 0.02–0.07, p = 0.001) and elevated SDQ scores. Specifically, these associations were evident in response to anger (B = 0.16, 95% CI 0.07–0.25, p = 0.001), anxiety (B = 0.13, 95% CI 0.05–0.21, p = 0.001), restlessness (B = 0.17, 95% CI 0.06–0.29, p = 0.004), and helplessness (B = 0.25, 95% CI 0.06–0.45, p = 0.011). These findings suggest that adolescents who engage in emotional eating may experience greater psychosocial challenges. This study underscores the importance of considering adolescent dietary habits as a crucial aspect in psychosocial health.

情绪性进食与几种不良健康结果有关，但对其与青少年心理社会健康关系的研究仍然有限。本研究的目的是调查西班牙青少年情绪化饮食与心理社会健康之间的关系。作为“健康饮食和日常生活活动”（EHDLA）研究的一部分，从西班牙利科特山谷（Valle de Ricote）所有三所中学的633名12-17岁的参与者（56.9%为女性）中收集了横断面数据。使用儿童和青少年情绪饮食量表（EES-C）评估情绪饮食，而使用优势和困难问卷（SDQ）测量心理社会健康。为了探讨情绪性饮食与心理社会健康之间的关系，应用了广义线性模型（GLMs）。结果显示，较高水平的整体情绪化饮食（非标准化β系数[B] = 0.04, 95%可信区间[CI] 0.02-0.07, p = 0.001）与较高的SDQ评分之间存在显著关联。具体来说，这些关联在愤怒（B = 0.16, 95% CI 0.07-0.25, p = 0.001）、焦虑（B = 0.13, 95% CI 0.05-0.21, p = 0.001）、不安（B = 0.17, 95% CI 0.06-0.29, p = 0.004）和无助（B = 0.25, 95% CI 0.06-0.45, p = 0.011）的反应中很明显。这些发现表明，情绪化进食的青少年可能会遇到更大的心理挑战。这项研究强调了将青少年饮食习惯作为心理社会健康的一个关键方面的重要性。

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引用次数: 0

Prevalence of Overweight/Obesity Among Under-Five Children in Lower Middle-Income Countries and Assessment of the Reported Associated Factors: A Systematic Review and Meta-Analysis 中低收入国家五岁以下儿童超重/肥胖患病率及相关因素评估：系统回顾和荟萃分析

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-09-14 DOI: 10.1111/ijpo.70055

Rounik Talukdar, Sombuddha Biswas, Anusha Seelamantula, Shubhajit Pahari, Debanjan Ghosh, Hari Krishna Raju Sagiraju

<div> <section> <h3> Background</h3> <p>Overweight/obesity among children under five is a growing global concern, especially in low- and middle-income countries (LMICs), yet consolidated evidence of this burden remains limited, which is crucial to target interventions. This review synthesises data from community-based studies to estimate the overall and individual pooled prevalences of overweight/obesity in this population and explores the factors associated.</p> </section> <section> <h3> Methodology</h3> <p>PubMed, Scopus and EMBASE were searched and screened for eligible studies published between April 2014 and 2024 individually by two researchers. Quality assessment of the eligible studies was conducted using the Joanna Briggs Institute (JBI) tool. Data regarding the prevalence of overweight, obesity and their associated factors, including maternal education, area of residence, maternal body weight, household incomes and breastfeeding practices, as reported in these included studies, were extracted. A random-effect model was used for the meta-analysis, and heterogeneity was evaluated using <i>I</i> <sup>2</sup> statistics. Sources of heterogeneity were explored through subgroup analyses comparing effect sizes across categories of geographic regions, overweight/obesity measurement guidelines, sample sizes and publication years. Meta-regression assessed the relationship between these variables and the pooled estimates.</p> </section> <section> <h3> Results</h3> <p>Of the 13 734 studies screened, 21 were eligible for inclusion. The pooled prevalence of overweight/obesity among the under-five children in LMICs was 8.57% (95% confidence interval (CI) 5.24–12.63, <i>I</i> <sup>2</sup> 100% at <i>p</i> value < 0.01) with significant heterogeneity. Overnutrition prevalence increased from 7.43% during the 5 years of 2014–2018 to 9.12% during 2019–2023. The pooled prevalence of overweight/obesity varied significantly across geography, with the highest prevalence in the African region (17%) and the lowest in the Southeast Asian region (3.41%). Across the four studies that reported maternal education, children of mothers with secondary school education or higher had increased odds of having overweight/obesity [Odds Ratio (OR) (95% CI): 1.51 (1.21–1.88)]. Prevalence estimates also differed significantly by gender, with 6.89% for under-five boys and 4.75% for girls [OR (95% CI): 1.48 (1.08–2.04)]. Although individual studies reported significant associations with other factors such as area of residence, maternal body weight, income status and breastfeeding practices, a meta-analysis could not be performed due to heterogeneity.</p> </section> <section>

背景：五岁以下儿童超重/肥胖是一个日益受到全球关注的问题，特别是在低收入和中等收入国家，但关于这一负担的综合证据仍然有限，这对有针对性的干预措施至关重要。本综述综合了来自社区研究的数据，以估计该人群中超重/肥胖的总体和个人汇总患病率，并探讨了相关因素。方法：检索PubMed， Scopus和EMBASE，筛选2014年4月至2024年4月期间由两位研究人员分别发表的符合条件的研究。使用乔安娜布里格斯研究所（JBI）工具对合格研究进行质量评估。提取了这些纳入研究中报告的有关超重、肥胖患病率及其相关因素的数据，包括产妇教育程度、居住地区、产妇体重、家庭收入和母乳喂养做法。meta分析采用随机效应模型，采用I2统计量评估异质性。通过亚组分析，比较不同地理区域、超重/肥胖测量指南、样本量和出版年份的效应量，探讨异质性的来源。meta回归评估了这些变量与汇总估计值之间的关系。结果：在筛选的13734项研究中，21项符合纳入条件。中低收入国家5岁以下儿童超重/肥胖的总患病率为8.57%（95%可信区间（CI） 5.24-12.63， p值为I2 100%）。结论：中低收入国家儿童营养过剩的趋势令人担忧，总体患病率接近少数高收入国家报告的估计值。地理差异、性别差异以及与孕产妇教育的关联都强调需要制定针对特定区域的政策，重点是社区参与和对日益严重的营养过剩问题的认识。

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引用次数: 0

Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood 暴露于金属混合物和儿童肥胖：在妊娠期和儿童晚期之间的高易感性时期的检查。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-09-14 DOI: 10.1111/ijpo.70057

Janice M. Y. Hu, Michael M. Borghese, Mandy Fisher, Joseph M. Braun, Katherine M. Morrison, Mark R. Palmert, Linda Booij, Constadina Panagiotopoulos, Jillian Ashley-Martin

Introduction

Childhood obesity is a public health concern. Studies have investigated the effects of metal mixtures on childhood obesity but none have identified periods of heightened susceptibility of exposure. We identified the periods by investigating the association of metal mixture, measured at four time points, with adiposity.

Materials and Methods

Using data from the Maternal-Infant Research on Environmental Chemicals Research Platform, we included 234 child–parent pairs. We measured whole blood metal concentrations during the first and third trimesters, early and late childhood. Outcomes were late childhood body mass index z-score (zBMI), body fat percentage (%BF) and waist circumference z-score (zWC). We used treed distributed lag mixture models (TDLMM) to investigate associations between metal mixture and adiposity. We also investigated associations using linear regression and conducted sex-specific analysis.

Results

Among females, arsenic was positively associated with zBMI and zWC. Regression results show that each doubling in third trimester arsenic concentrations was associated with 0.16 (95% CI: 0.02, 0.31) and 0.13 (95% CI: 0.01, 0.25) increase in zBMI and zWC, respectively. TDLMM results were similar but attenuated. We also observed negative associations between third trimester cadmium and zWC, null associations between other metals and adiposity and among males and no metal interactions.

Conclusion

Third trimester is a period of heightened susceptibility to obesogenic effects of arsenic exposure in females.

儿童肥胖是一个公共卫生问题。研究调查了金属混合物对儿童肥胖的影响，但没有一项研究确定了易受接触的时期。我们通过调查在四个时间点测量的金属混合物与肥胖的关系来确定这些时期。材料与方法：使用环境化学品研究平台母婴研究数据，纳入234对亲子对。我们测量了孕早期和孕晚期、儿童早期和晚期全血金属浓度。结果为儿童晚期体重指数z-score （zBMI）、体脂率（%BF）和腰围z-score （zWC）。我们使用树分布滞后混合模型（TDLMM）来研究金属混合物与肥胖之间的关系。我们还使用线性回归研究了相关性，并进行了性别分析。结果：在女性中，砷与zBMI和zWC呈正相关。回归结果显示，妊娠晚期砷浓度每增加一倍，zBMI和zWC分别增加0.16 （95% CI: 0.02, 0.31）和0.13 （95% CI: 0.01, 0.25）。TDLMM结果相似，但有所减弱。我们还观察到妊娠晚期镉和zWC之间的负相关，其他金属与肥胖和男性之间的零关联，没有金属相互作用。结论：妊娠晚期是女性砷暴露致肥易感性增高的时期。

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引用次数: 0

The Risk of Intra-Familial Stigmatisation in Family-Based Treatment of Childhood Obesity. A Position Statement of the European Childhood Obesity Group 以家庭为基础的儿童肥胖治疗中的家族内歧视风险。欧洲儿童肥胖小组的立场声明。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-09-08 DOI: 10.1111/ijpo.70054

D. Hoeeg, D. Grabowski, G. Torbahn, T. Handjieva-Darlenska, E. Luszczki, E. Vlachopapadopoulou, A. Vania, D. Thivel, D. Weghuber, C. Braet

Intra-familial weight stigma is a subtle yet impactful dynamic that may influence the outcomes of family-based interventions aimed at treating childhood obesity. While much attention has been paid to societal and peer-related weight stigma, less focus has been placed on how stigma manifests within families. This position statement highlights the importance of recognising that such stigma can unintentionally arise in the home. Drawing on recent qualitative research, we outline the social mechanisms that contribute to intra-familial weight stigma and provide key recommendations for addressing it. We emphasise the need to attend to family dynamics, support parents in changing their own habits, and involve siblings and extended family members to ensure a truly family-focused and person-centred intervention. Ultimately, preventing intra-familial weight stigma and fostering a supportive family environment are essential steps toward improving both psychological and physical health outcomes in the treatment of childhood obesity.

家族内体重耻辱感是一种微妙但有影响力的动态，可能会影响以家庭为基础的儿童肥胖治疗干预措施的结果。虽然人们对社会和与同龄人相关的体重耻辱给予了很多关注，但对耻辱如何在家庭中表现出来的关注却很少。这一立场声明强调了认识到这种耻辱可能在家庭中无意中产生的重要性。根据最近的定性研究，我们概述了导致家族内体重耻辱感的社会机制，并提供了解决这一问题的关键建议。我们强调需要关注家庭动态，支持父母改变自己的习惯，并让兄弟姐妹和大家庭成员参与进来，以确保真正以家庭为中心和以人为本的干预。最终，预防家族内的体重耻辱感和培养支持性的家庭环境是改善儿童肥胖治疗中心理和身体健康结果的关键步骤。

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引用次数: 0

Leukocyte telomere length and birth characteristics associated with obesity in infancy in a predominantly Latinx cohort. 在一个以拉丁裔为主的队列中，白细胞端粒长度和出生特征与婴儿肥胖有关。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI: 10.1111/ijpo.70034

Abigail Duque, Jue Lin, Laura Jeliffe-Pawlowski, Kim Coleman-Phox, Larry Rand, Janet M Wojcicki

Background: Previous studies suggest that in utero exposures may impact future weight gain trajectories in infancy. Leukocyte telomere length (LTL) collected at birth may be an additional variable to test in models for childhood obesity as adult studies suggest that LTL may be predictive of metabolic disease.

Methods: Using a primarily Latinx mother-child longitudinal cohort design, we assessed the relationship between newborn LTL measured via quantitative PCR and obesity at 12 months (WFA ≥ 95th percentile). Secondary outcomes included weight-for-age (WFA) Z scores at 12 months and covariates included birth anthropometrics and maternal prenatal health. Logistic and linear regression models were used to assess independent predictors for infant obesity and WFA Z scores.

Results: We followed 302 children until 12 months including 65.89% with Latinx ethnicity and 4.97% had obesity at 12 months. Independent predictors of obesity at 12 months included higher birthweight Z scores (OR 2.24, 1.16, 5.05) and WFA Z scores at 6 months (OR 1.56, 1.19, 2.05). Longer LTL at birth and higher Apgar scores at 5 min were protective (OR 0.04, 95%CI 0.002, 0.79 and OR 0.30, 95%CI 0.13-0.72, respectively). LTL at birth was negatively associated with WFA Z scores at 12 months of age in multivariable models (Coeff = -0.58, 95%CI -1.05, -0.12).

Conclusions: LTL at birth may be a marker, in addition to birthweight, that can be used to assess an infant's risk for subsequent obesity. Future studies are needed to better assess and determine possible maternal exposures associated with shorter newborn LTL.

背景：先前的研究表明，子宫内暴露可能会影响婴儿时期体重增加的轨迹。出生时收集的白细胞端粒长度（LTL）可能是儿童肥胖模型中测试的另一个变量，因为成人研究表明LTL可能预测代谢性疾病。方法：采用主要为拉丁裔的母婴纵向队列设计，我们评估了通过定量PCR测量的新生儿LTL与12个月时肥胖（WFA≥95百分位）之间的关系。次要结局包括12个月时的年龄体重（WFA） Z评分，协变量包括出生人体测量和产妇产前健康。采用Logistic和线性回归模型评估婴儿肥胖和WFA Z评分的独立预测因子。结果：我们随访了302名儿童至12个月，其中65.89%为拉丁裔，4.97%为12个月时肥胖。12个月时肥胖的独立预测因子包括较高的出生体重Z评分（OR 2.24, 1.16, 5.05）和6个月时的WFA Z评分（OR 1.56, 1.19, 2.05）。出生时较长的LTL和5分钟时较高的Apgar评分具有保护作用（分别为OR 0.04, 95%CI 0.002, 0.79和OR 0.30, 95%CI 0.13-0.72）。在多变量模型中，出生时的LTL与12月龄时的WFA Z评分呈负相关（Coeff = -0.58, 95%CI -1.05, -0.12）。结论：除了出生体重外，出生时的LTL可能是一个可用于评估婴儿随后肥胖风险的标志。未来的研究需要更好地评估和确定可能与较短新生儿LTL相关的母亲暴露。

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引用次数: 0