Tyler J. Dobbs, Linnea Gutierrez, Houchun Harry Hu, Kendall S. Hunter, Brian Fonseca, Lorna Browne, David Winter, Melanie G. Cree, Laura Pyle, Jonathan L. Hills-Dunlap, Jane E. B. Reusch, Megan M. Kelsey, Thomas H. Inge, Petter Bjornstad, Kristen J. Nadeau
Background
Adolescents with youth-onset type 2 diabetes (YO-T2D) have an increased risk for cardiometabolic complications. The impact of vertical sleeve gastrectomy (VSG) on fat distribution and cardiac morphology/function in YO-T2D is unknown.
Objectives
To evaluate changes in body composition, abdominal and cardiac fat depots, and cardiometabolic health in adolescents with YO-T2D undergoing VSG.
Methods
Anthropometrics, labs and imaging were used to assess participants pre-surgery and 3–12 months post-surgery. MRI quantified pericardial (PAT), epicardial (EAT), subcutaneous (SAT) and visceral adipose tissue (VAT), hepatic fat fraction (HFF) and cardiac morphology/function. Mixed-effects models assessed longitudinal changes.
Results
By 12 months, weight decreased from 134.3 ± 5.1 to 103.3 ± 5.2 kg, VAT 1943 ± 148 to 1248 ± 150 cm3, HFF 23.2% ± 2.3% to 5.3% ± 2.3% and PAT and EAT by 27% and 33% (all p < 0.01). Homeostatic model assessment of insulin resistance (HOMA-IR) improved (7.8 ± 1.2 to 1.7 ± 1.2 [p < 0.01]). BMI, SAT, resting heart rate (RHR), left ventricular (LV) mass and cardiac output (CO) also decreased (all p < 0.05). VAT decreases correlated with decreases in HFF (r = 0.70, p = 0.01), HOMA-IR (r = 0.60, p = 0.04) and CO (r = 0.70, p = 0.03). HFF decreases correlated with decreases in BMI (r = 0.70, p = 0.03), HOMA-IR (r = 0.90, p < 0.001), RHR (r = 0.90, p = 0.002), CO (r = 0.80, p = 0.007) and LV mass (r = 0.70, p = 0.02).
Conclusions
VSG reduces ectopic and regional fat and improves associated insulin sensitivity and cardiac health in adolescents with YO-T2D.
{"title":"MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes","authors":"Tyler J. Dobbs, Linnea Gutierrez, Houchun Harry Hu, Kendall S. Hunter, Brian Fonseca, Lorna Browne, David Winter, Melanie G. Cree, Laura Pyle, Jonathan L. Hills-Dunlap, Jane E. B. Reusch, Megan M. Kelsey, Thomas H. Inge, Petter Bjornstad, Kristen J. Nadeau","doi":"10.1111/ijpo.70068","DOIUrl":"10.1111/ijpo.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adolescents with youth-onset type 2 diabetes (YO-T2D) have an increased risk for cardiometabolic complications. The impact of vertical sleeve gastrectomy (VSG) on fat distribution and cardiac morphology/function in YO-T2D is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate changes in body composition, abdominal and cardiac fat depots, and cardiometabolic health in adolescents with YO-T2D undergoing VSG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Anthropometrics, labs and imaging were used to assess participants pre-surgery and 3–12 months post-surgery. MRI quantified pericardial (PAT), epicardial (EAT), subcutaneous (SAT) and visceral adipose tissue (VAT), hepatic fat fraction (HFF) and cardiac morphology/function. Mixed-effects models assessed longitudinal changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>By 12 months, weight decreased from 134.3 ± 5.1 to 103.3 ± 5.2 kg, VAT 1943 ± 148 to 1248 ± 150 cm<sup>3</sup>, HFF 23.2% ± 2.3% to 5.3% ± 2.3% and PAT and EAT by 27% and 33% (all <i>p</i> < 0.01). Homeostatic model assessment of insulin resistance (HOMA-IR) improved (7.8 ± 1.2 to 1.7 ± 1.2 [<i>p</i> < 0.01]). BMI, SAT, resting heart rate (RHR), left ventricular (LV) mass and cardiac output (CO) also decreased (all <i>p</i> < 0.05). VAT decreases correlated with decreases in HFF (<i>r</i> = 0.70, <i>p</i> = 0.01), HOMA-IR (<i>r</i> = 0.60, <i>p</i> = 0.04) and CO (<i>r</i> = 0.70, <i>p</i> = 0.03). HFF decreases correlated with decreases in BMI (<i>r</i> = 0.70, <i>p</i> = 0.03), HOMA-IR (<i>r</i> = 0.90, <i>p</i> < 0.001), RHR (<i>r</i> = 0.90, <i>p</i> = 0.002), CO (<i>r</i> = 0.80, <i>p</i> = 0.007) and LV mass (<i>r</i> = 0.70, <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>VSG reduces ectopic and regional fat and improves associated insulin sensitivity and cardiac health in adolescents with YO-T2D.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeralyn B. Jacobs, Haihong Hu, Seohyun Kim, Yi-shin Sheu, R. Clayton Bishop, Karen Chesbrough, Nancy S. Weinfield
Background
During the COVID-19 pandemic, there was a rise in the incidence of type 2 diabetes (T2D) and prediabetes in children and teenagers. We investigated whether new risk factors for diabetes in children emerged during the pandemic period.
Methods
Using health records of a large, integrated health system, we evaluated the incidence of new-onset T2D and prediabetes in patients aged 0–19 years from 2020 to 2023. We utilised descriptive statistics, chi-square and multivariable logistic regressions to predict the risk of T2D and prediabetes.
Results
Compared to children with normal weight, children with obesity (p < 0.0001) and those overweight (p < 0.0001) were more likely to develop prediabetes, and children with obesity were more likely to develop T2D (p < 0.0001). Children aged 12–19 were more likely to develop prediabetes (p < 0.0001) and T2D (p < 0.0001) compared to younger children. Publicly insured children were more likely to develop T2D (p = 0.003). Black and Asian children were at higher risk than White individuals of developing both prediabetes (p < 0.0001) and T2D (p = 0.019 and p = 0.02, respectively). COVID-19 infection was not a meaningful risk factor for prediabetes or T2D.
Conclusion
Risk factors for prediabetes and T2D in children remained the same during the pandemic as prior: adolescents, overweight/obese patients, publicly insured individuals and non-White individuals.
{"title":"Risk Factors for Development of Type 2 and Prediabetes in Children During the COVID-19 Pandemic","authors":"Jeralyn B. Jacobs, Haihong Hu, Seohyun Kim, Yi-shin Sheu, R. Clayton Bishop, Karen Chesbrough, Nancy S. Weinfield","doi":"10.1111/ijpo.70070","DOIUrl":"10.1111/ijpo.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>During the COVID-19 pandemic, there was a rise in the incidence of type 2 diabetes (T2D) and prediabetes in children and teenagers. We investigated whether new risk factors for diabetes in children emerged during the pandemic period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using health records of a large, integrated health system, we evaluated the incidence of new-onset T2D and prediabetes in patients aged 0–19 years from 2020 to 2023. We utilised descriptive statistics, chi-square and multivariable logistic regressions to predict the risk of T2D and prediabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to children with normal weight, children with obesity (<i>p</i> < 0.0001) and those overweight (<i>p</i> < 0.0001) were more likely to develop prediabetes, and children with obesity were more likely to develop T2D (<i>p</i> < 0.0001). Children aged 12–19 were more likely to develop prediabetes (<i>p</i> < 0.0001) and T2D (<i>p</i> < 0.0001) compared to younger children. Publicly insured children were more likely to develop T2D (<i>p</i> = 0.003). Black and Asian children were at higher risk than White individuals of developing both prediabetes (<i>p</i> < 0.0001) and T2D (<i>p</i> = 0.019 and <i>p</i> = 0.02, respectively). COVID-19 infection was not a meaningful risk factor for prediabetes or T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Risk factors for prediabetes and T2D in children remained the same during the pandemic as prior: adolescents, overweight/obese patients, publicly insured individuals and non-White individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Childhood obesity poses a global health threat, with emerging evidence suggesting distinct adipocyte senescence patterns compared to adult-onset obesity. We systematically explored whether childhood obesity may be causally associated with age-related diseases through a meta-analysis of Mendelian randomization (MR) evidence.
Methods
We screened six databases (MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library and CNKI) and identified 45 MR articles examining paediatric adiposity and major age-related diseases. For each disease, we performed a meta-analysis using results from published MR studies and conducted de novo analyses based on genetic data from UK Biobank (n = 453 169), FinnGen (n > 200 000) and other large consortiums.
Results
The meta-analysis examined 44 diseases across 9 systems, revealing suggestive associations between genetically determined childhood obesity and increased risk of 16 age-related diseases, including hypertension, atrial fibrillation, coronary artery disease, stroke and myocardial infarction; colorectal, endometrial and pancreatic cancers; nonalcoholic fatty liver disease, type 2 diabetes, diabetic nephropathy; multiple sclerosis and gout; Alzheimer's disease; depression and asthma. Three of these associations were marginal (p = 0.03–0.05). Paradoxical inverse associations emerged for breast cancer and ulcerative colitis.
Conclusion
The findings from this meta-analysis underscore associations between childhood adiposity and multisystem age-related pathologies, underscoring the imperative for early obesity prevention.
{"title":"Childhood Obesity and Age-Related Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Evidence","authors":"Haoxue Zhu, Xinghao Yi, Mengyu He, Siyi Wu, Ming Li, Shan Gao","doi":"10.1111/ijpo.70071","DOIUrl":"10.1111/ijpo.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Childhood obesity poses a global health threat, with emerging evidence suggesting distinct adipocyte senescence patterns compared to adult-onset obesity. We systematically explored whether childhood obesity may be causally associated with age-related diseases through a meta-analysis of Mendelian randomization (MR) evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We screened six databases (MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library and CNKI) and identified 45 MR articles examining paediatric adiposity and major age-related diseases. For each disease, we performed a meta-analysis using results from published MR studies and conducted de novo analyses based on genetic data from UK Biobank (<i>n</i> = 453 169), FinnGen (<i>n</i> > 200 000) and other large consortiums.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The meta-analysis examined 44 diseases across 9 systems, revealing suggestive associations between genetically determined childhood obesity and increased risk of 16 age-related diseases, including hypertension, atrial fibrillation, coronary artery disease, stroke and myocardial infarction; colorectal, endometrial and pancreatic cancers; nonalcoholic fatty liver disease, type 2 diabetes, diabetic nephropathy; multiple sclerosis and gout; Alzheimer's disease; depression and asthma. Three of these associations were marginal (<i>p</i> = 0.03–0.05). Paradoxical inverse associations emerged for breast cancer and ulcerative colitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings from this meta-analysis underscore associations between childhood adiposity and multisystem age-related pathologies, underscoring the imperative for early obesity prevention.</p>\u0000 \u0000 <div>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cassandra Comey, Kenisha Russell Jonsson, Maria Corell
Background
In Sweden, schoolwork pressure and adolescent overweight/obesity prevalence have increased in recent decades. This study investigates the relationship between schoolwork pressure and weight status, considering the moderating role of socioeconomic background.
Methods
We analysed pooled cross-sectional data from 12 154 adolescents in the nationally representative Swedish Health Behaviour in School-aged Children surveys (2013/14, 2017/18, 2021/22). Logistic regression models examined the association between schoolwork pressure and self-reported overweight/obesity status (standardised by IOTF cut-offs) across socioeconomic backgrounds assessed by the Family Affluence Scale (FAS) and perceived family wealth (PFW). We calculated population attributable fractions to quantify schoolwork pressure's contribution to overweight/obesity.
Results
37% of students reported high schoolwork pressure, and 14% had overweight or obesity. High schoolwork pressure was associated with increased odds of overweight/obesity (OR 1.17, 95% CI 1.03–1.32). Adolescents experiencing high pressure from low socioeconomic backgrounds FAS (OR 2.10, 95% CI 1.60–2.76) or PFW (OR 1.82, 95% CI 1.22–2.71) had the highest odds of overweight/obesity. Approximately 5% of overweight/obesity cases were attributable to high schoolwork pressure.
Conclusions
High schoolwork pressure increases the likelihood of adolescent overweight/obesity, particularly for disadvantaged socioeconomic groups. Implementing policies to reduce academic stress and providing targeted support are essential for promoting healthier outcomes.
背景：在瑞典，近几十年来，学业压力和青少年超重/肥胖患病率有所增加。本研究探讨学业压力与体重状况的关系，并考虑社会经济背景的调节作用。方法：我们分析了全国代表性瑞典学龄儿童健康行为调查（2013/14、2017/18、2021/22）中12154名青少年的汇总横截面数据。逻辑回归模型检验了家庭富裕量表（FAS）和感知家庭财富（PFW）评估的社会经济背景下，学业压力与自我报告的超重/肥胖状况（由IOTF截止值标准化）之间的关系。我们计算了人口归因分数来量化学业压力对超重/肥胖的贡献。结果：37%的学生报告了高中学业压力，14%的学生超重或肥胖。高中学业压力与超重/肥胖的几率增加相关（OR 1.17, 95% CI 1.03-1.32）。来自低社会经济背景（FAS） （OR 2.10, 95% CI 1.60-2.76）或PFW （OR 1.82, 95% CI 1.22-2.71）的高压力青少年超重/肥胖的几率最高。大约5%的超重/肥胖病例可归因于高中学业压力。结论：高中学业压力增加了青少年超重/肥胖的可能性，特别是对社会经济弱势群体。实施减轻学业压力的政策和提供有针对性的支持对于促进更健康的结果至关重要。
{"title":"The Association Between Schoolwork Pressure and Overweight/Obesity in Swedish Schoolchildren Across Different Socioeconomic Groups","authors":"Cassandra Comey, Kenisha Russell Jonsson, Maria Corell","doi":"10.1111/ijpo.70067","DOIUrl":"10.1111/ijpo.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In Sweden, schoolwork pressure and adolescent overweight/obesity prevalence have increased in recent decades. This study investigates the relationship between schoolwork pressure and weight status, considering the moderating role of socioeconomic background.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analysed pooled cross-sectional data from 12 154 adolescents in the nationally representative Swedish Health Behaviour in School-aged Children surveys (2013/14, 2017/18, 2021/22). Logistic regression models examined the association between schoolwork pressure and self-reported overweight/obesity status (standardised by IOTF cut-offs) across socioeconomic backgrounds assessed by the Family Affluence Scale (FAS) and perceived family wealth (PFW). We calculated population attributable fractions to quantify schoolwork pressure's contribution to overweight/obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>37% of students reported high schoolwork pressure, and 14% had overweight or obesity. High schoolwork pressure was associated with increased odds of overweight/obesity (OR 1.17, 95% CI 1.03–1.32). Adolescents experiencing high pressure from low socioeconomic backgrounds FAS (OR 2.10, 95% CI 1.60–2.76) or PFW (OR 1.82, 95% CI 1.22–2.71) had the highest odds of overweight/obesity. Approximately 5% of overweight/obesity cases were attributable to high schoolwork pressure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>High schoolwork pressure increases the likelihood of adolescent overweight/obesity, particularly for disadvantaged socioeconomic groups. Implementing policies to reduce academic stress and providing targeted support are essential for promoting healthier outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The longitudinal trajectory of body mass index (BMI) and brain structure development during peri-adolescence is not clearly defined in offspring prenatally exposed to gestational diabetes mellitus (GDM) versus unexposed offspring.
Methods
Participants between age 9 and 10 years (N = 9583) were included from the Adolescent Brain and Cognitive Development (ABCD) Study and followed yearly through 4-year follow-up. GDM and puberty status were self-reported. BMI was calculated yearly, and MRI assessed brain structure biennially. Mixed-effects models analysed trajectories of BMI and brain structural measures between groups controlling for sociodemographic covariates, and linear spline was defined with a knot at the onset of puberty.
Results
There was an interaction of exposure by age in change in BMI [β (95% CI) = 0.032 (0.008, 0.056), p = 0.009] and mean cortical thickness [β (95% CI) = −0.038 (−0.071, −0.004), p = 0.027]. The former was driven by greater pre-pubertal increases in BMI [β (95% CI) = 0.051 (0.002, 0.100), p = 0.043], whereas the latter was driven by faster post-pubertal declines in cortical thickness among GDM-exposed offspring [β (95% CI) = −0.051 (−0.095, −0.007), p = 0.046].
Conclusion
Prenatal GDM exposure is associated with greater pre-pubertal increases in BMI and faster post-pubertal cortical thinning in youth aged between 9 and 15.
{"title":"Prenatal Exposure to Gestational Diabetes Mellitus Is Associated With Greater Pre-Pubertal BMI Growth and Faster Post-Pubertal Cortical Thinning During Peri-Adolescence","authors":"Eustace Hsu, Trevor A. Pickering, Shan Luo","doi":"10.1111/ijpo.70069","DOIUrl":"10.1111/ijpo.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The longitudinal trajectory of body mass index (BMI) and brain structure development during peri-adolescence is not clearly defined in offspring prenatally exposed to gestational diabetes mellitus (GDM) versus unexposed offspring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants between age 9 and 10 years (<i>N</i> = 9583) were included from the Adolescent Brain and Cognitive Development (ABCD) Study and followed yearly through 4-year follow-up. GDM and puberty status were self-reported. BMI was calculated yearly, and MRI assessed brain structure biennially. Mixed-effects models analysed trajectories of BMI and brain structural measures between groups controlling for sociodemographic covariates, and linear spline was defined with a knot at the onset of puberty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was an interaction of exposure by age in change in BMI [β (95% CI) = 0.032 (0.008, 0.056), <i>p</i> = 0.009] and mean cortical thickness [β (95% CI) = −0.038 (−0.071, −0.004), <i>p</i> = 0.027]. The former was driven by greater pre-pubertal increases in BMI [β (95% CI) = 0.051 (0.002, 0.100), <i>p</i> = 0.043], whereas the latter was driven by faster post-pubertal declines in cortical thickness among GDM-exposed offspring [β (95% CI) = −0.051 (−0.095, −0.007), <i>p</i> = 0.046].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Prenatal GDM exposure is associated with greater pre-pubertal increases in BMI and faster post-pubertal cortical thinning in youth aged between 9 and 15.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Euisun Pyo, Regine Haardörfer, Liliana Aguayo, Miriam Vos, Mary Beth Weber, Jean A. Welsh
U.S. acculturation is associated with poor diet quality and obesity. This study examined the association of acculturation with added sugars among Mexican American adolescents, and whether added sugars mediate the association between acculturation and overweight/obesity. Data from NHANES 2009–2018 included 1317 Mexican American adolescents aged 12–19 years. Acculturation was measured by language spoken at home (English vs. Spanish) and birthplace of child and caregiver (United States vs. Mexico). Added sugars intake was assessed by 24-h dietary recall and categorised as ‘high’ (≥ 10% total energy intake) versus ‘low’ (< 10%). Multivariable logistic regressions tested associations between acculturation and added sugars, and path analysis evaluated the mediation of added sugars between acculturation and overweight/obesity (≥ 85th BMI percentile). Greater acculturation, indicated by primarily speaking English at home (OR: 1.6; 95% CI: 1.0, 2.5), caregiver being U.S.-born (2.2; 1.1, 4.2), both child and caregiver U.S.-born (2.8; 1.2, 6.5), or both U.S.-born + English at home (2.9; 1.1, 7.5), was associated with higher odds of high added sugars intake. Added sugars did not mediate the effect of acculturation on obesity/overweight status. These findings suggest that while higher acculturation is associated with excess added sugars intake, future research is needed to clarify how acculturation influences obesity risk.
{"title":"Associations of Acculturation With Added Sugars Intake and Weight Status Among Mexican American Adolescents in the United States, NHANES, 2009–2018","authors":"Euisun Pyo, Regine Haardörfer, Liliana Aguayo, Miriam Vos, Mary Beth Weber, Jean A. Welsh","doi":"10.1111/ijpo.70063","DOIUrl":"10.1111/ijpo.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>U.S. acculturation is associated with poor diet quality and obesity. This study examined the association of acculturation with added sugars among Mexican American adolescents, and whether added sugars mediate the association between acculturation and overweight/obesity. Data from NHANES 2009–2018 included 1317 Mexican American adolescents aged 12–19 years. Acculturation was measured by language spoken at home (English vs. Spanish) and birthplace of child and caregiver (United States vs. Mexico). Added sugars intake was assessed by 24-h dietary recall and categorised as ‘high’ (≥ 10% total energy intake) versus ‘low’ (< 10%). Multivariable logistic regressions tested associations between acculturation and added sugars, and path analysis evaluated the mediation of added sugars between acculturation and overweight/obesity (≥ 85th BMI percentile). Greater acculturation, indicated by primarily speaking English at home (OR: 1.6; 95% CI: 1.0, 2.5), caregiver being U.S.-born (2.2; 1.1, 4.2), both child and caregiver U.S.-born (2.8; 1.2, 6.5), or both U.S.-born + English at home (2.9; 1.1, 7.5), was associated with higher odds of high added sugars intake. Added sugars did not mediate the effect of acculturation on obesity/overweight status. These findings suggest that while higher acculturation is associated with excess added sugars intake, future research is needed to clarify how acculturation influences obesity risk.</p>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanie A. Dratva, Zoe L. Lanman, Amanda Bischoff-Grethe, Dawn M. Eichen, David R. Strong, Christina E. Wierenga, Kerri N. Boutelle
<div> <section> <h3> Background</h3> <p>Children with overweight or obesity (OW/OB), relative to healthy weight (HW), have lower cognitive performance and hippocampal volumes. Whether this extends to children with HW at familial risk for future OW/OB is unknown.</p> </section> <section> <h3> Objectives</h3> <p>To compare memory performance and hippocampal subfield volumes between HW children at high risk (HR) and low risk (LR) for OW/OB.</p> </section> <section> <h3> Methods</h3> <p>HW children (<i>n</i> = 95, aged 8–11), classified as HR (<i>n</i> = 43, both parents with OW/OB) or LR (<i>n</i> = 52, both parents with HW), underwent structural magnetic resonance imaging and memory testing (Verbal List Learning Test-Food-Child Version (VLLT-Food-C) and Child Memory Scale subtests: word pairs, dot locations). Linear models tested group differences in memory scores, hippocampal and subfield (CA1, CA3, dentate gyrus (DG), subiculum) volumes.</p> </section> <section> <h3> Results</h3> <p>Groups did not differ on demographics except body mass index (HR > LR, <i>p</i> = 0.003), despite all children being HW. LR children performed better on VLLT-Food-C short- (<span></span><math> <semantics> <mrow> <mi>β</mi> </mrow> <annotation>$$ beta $$</annotation> </semantics></math> = 0.34, <i>p</i> < 0.01) and long-delay cued recall (<span></span><math> <semantics> <mrow> <mi>β</mi> </mrow> <annotation>$$ beta $$</annotation> </semantics></math> = 0.21, <i>p</i> = 0.04) and word pairs delayed recall (<span></span><math> <semantics> <mrow> <mi>β</mi> </mrow> <annotation>$$ beta $$</annotation> </semantics></math> = 0.21, <i>p</i> = 0.04). Children with HR had smaller bilateral whole hippocampus, CA1, DG and right CA3 volumes (<i>p</i>s < 0.05); only the right DG remained significant (<span></span><math> <semantics> <mrow> <mi>β</mi> </mrow> <annotation>$$ beta $$</annotation> </semantics></math> = 0.15, <i>p</i> = 0.04) after intracranial volume adjustment.</p> </section> <section> <h3> Conclusions</h3> <p>Memory and hippocampal volume differences may reflect underlying familial
背景：与健康体重（HW）相比，超重或肥胖儿童（OW/OB）的认知能力和海马体积较低。这是否适用于有家族性OW/OB风险的HW患儿尚不清楚。目的：比较OW/OB高风险（HR）和低风险（LR） HW儿童的记忆表现和海马亚区体积。方法：HW儿童（n = 95，年龄8-11岁），分为HR组（n = 43，父母双方均患有OW/OB）和LR组（n = 52，父母双方均患有HW），采用结构磁共振成像和记忆测试（言语表学习测试-食物-儿童版（VLLT-Food-C）和儿童记忆量表子测试：单词对、点位置）。线性模型测试各组在记忆评分、海马和子区（CA1、CA3、齿状回（DG）、丘下）体积方面的差异。结果：各组在人口统计学上没有差异，除了身体质量指数（HR > LR, p = 0.003），尽管所有儿童都是高体重。LR儿童在VLLT-Food-C短记忆（β $$ beta $$ = 0.34, p β $$ beta $$ = 0.21, p = 0.04）和单词对延迟回忆（β $$ beta $$ = 0.21, p = 0.04）上表现较好。颅内容积调整后，HR患儿双侧海马全区、CA1、DG、右侧CA3体积减小（ps β $$ beta $$ = 0.15, p = 0.04）。结论：记忆和海马体积的差异可能反映了HW儿童OW/OB的潜在家族风险。
{"title":"Memory Performance and Hippocampal Volumes in Healthy Weight Children at High- and Low-Familial Risk for Obesity","authors":"Melanie A. Dratva, Zoe L. Lanman, Amanda Bischoff-Grethe, Dawn M. Eichen, David R. Strong, Christina E. Wierenga, Kerri N. Boutelle","doi":"10.1111/ijpo.70061","DOIUrl":"10.1111/ijpo.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Children with overweight or obesity (OW/OB), relative to healthy weight (HW), have lower cognitive performance and hippocampal volumes. Whether this extends to children with HW at familial risk for future OW/OB is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare memory performance and hippocampal subfield volumes between HW children at high risk (HR) and low risk (LR) for OW/OB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>HW children (<i>n</i> = 95, aged 8–11), classified as HR (<i>n</i> = 43, both parents with OW/OB) or LR (<i>n</i> = 52, both parents with HW), underwent structural magnetic resonance imaging and memory testing (Verbal List Learning Test-Food-Child Version (VLLT-Food-C) and Child Memory Scale subtests: word pairs, dot locations). Linear models tested group differences in memory scores, hippocampal and subfield (CA1, CA3, dentate gyrus (DG), subiculum) volumes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Groups did not differ on demographics except body mass index (HR > LR, <i>p</i> = 0.003), despite all children being HW. LR children performed better on VLLT-Food-C short- (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>β</mi>\u0000 </mrow>\u0000 <annotation>$$ beta $$</annotation>\u0000 </semantics></math> = 0.34, <i>p</i> < 0.01) and long-delay cued recall (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>β</mi>\u0000 </mrow>\u0000 <annotation>$$ beta $$</annotation>\u0000 </semantics></math> = 0.21, <i>p</i> = 0.04) and word pairs delayed recall (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>β</mi>\u0000 </mrow>\u0000 <annotation>$$ beta $$</annotation>\u0000 </semantics></math> = 0.21, <i>p</i> = 0.04). Children with HR had smaller bilateral whole hippocampus, CA1, DG and right CA3 volumes (<i>p</i>s < 0.05); only the right DG remained significant (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>β</mi>\u0000 </mrow>\u0000 <annotation>$$ beta $$</annotation>\u0000 </semantics></math> = 0.15, <i>p</i> = 0.04) after intracranial volume adjustment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Memory and hippocampal volume differences may reflect underlying familial","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brooke E. Wagner, Annika B. Kruse, Sarah C. Armstrong, Asheley C. Skinner, Karen A. Scherr
Background
The 2023 Clinical Practice Guideline for pediatric obesity recommends immediate, intensive treatment, including behavioral therapy, medications, and surgery when indicated. Understanding parental agreement with the guideline is critical for successful implementation.
Objective
To evaluate parental awareness of and agreement with the guideline.
Methods
Parents (n = 150; 62.9% female; 75.5% White; Mage = 37.6 ± 7.4 years) completed an online survey assessing guideline awareness and agreement. K-means cluster analysis identified parent subgroups based on agreement patterns. Linear regression examined predictors of agreement (e.g., parent age, BMI). Inductive content analysis explored underlying perspectives.
Results
Few parents (5.3%) were aware of the guideline before the survey. Cluster analysis identified three subgroups: Guideline Skeptics (34%; broadly disagreed), Selective Supporters (28%; mostly agreed but opposed medications and surgery), and Guideline Supporters (38%; broadly agreed). Higher parental BMI predicted lower agreement (β = −0.20, p = 0.018). Qualitative findings added nuance to parents' preference for lifestyle changes, highlighted concerns about mental health and eating disorders, and emphasized parental responsibility in the development and treatment of obesity.
Conclusions
Parental agreement with the guideline varies widely. While most support behavioral treatment, many express concerns about medications and surgery, and a subset of “Guideline Skeptics” reject core principles such as the use of BMI. Tailored implementation strategies are needed to address these diverse views.
背景：2023儿科肥胖临床实践指南建议立即进行强化治疗，包括行为治疗、药物治疗和必要时的手术治疗。理解家长同意指导方针是成功实施的关键。目的：评价家长对该指南的认知度和认同程度。方法：150名家长（女性62.9%，白人75.5%，年龄37.6±7.4岁）完成在线问卷调查，评估家长对指南的认知和认同。K-means聚类分析根据一致性模式确定父子组。线性回归检验了一致性的预测因子（如父母年龄、体重指数）。归纳性内容分析探究了潜在的观点。结果：调查前很少有家长知晓该指南（5.3%）。聚类分析确定了三个亚组：指南怀疑论者（34%；广泛不同意），选择性支持者（28%；大部分同意但反对药物和手术）和指南支持者（38%；广泛同意）。父母BMI越高，一致性越低（β = -0.20, p = 0.018）。定性研究发现，父母对改变生活方式的偏好有细微差别，强调了对心理健康和饮食失调的关注，并强调了父母在肥胖发展和治疗中的责任。结论：家长对指南的认同差异很大。虽然大多数人支持行为治疗，但许多人表达了对药物和手术的担忧，还有一部分“指南怀疑论者”拒绝使用BMI等核心原则。需要量身定制的实施战略来处理这些不同的观点。
{"title":"Parent Perspectives on the 2023 Clinical Practice Guideline for Pediatric Obesity: A Mixed-Methods Study of Acceptance and Concerns","authors":"Brooke E. Wagner, Annika B. Kruse, Sarah C. Armstrong, Asheley C. Skinner, Karen A. Scherr","doi":"10.1111/ijpo.70065","DOIUrl":"10.1111/ijpo.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The 2023 Clinical Practice Guideline for pediatric obesity recommends immediate, intensive treatment, including behavioral therapy, medications, and surgery when indicated. Understanding parental agreement with the guideline is critical for successful implementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate parental awareness of and agreement with the guideline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Parents (<i>n</i> = 150; 62.9% female; 75.5% White; <i>M</i><sub>age</sub> = 37.6 ± 7.4 years) completed an online survey assessing guideline awareness and agreement. K-means cluster analysis identified parent subgroups based on agreement patterns. Linear regression examined predictors of agreement (e.g., parent age, BMI). Inductive content analysis explored underlying perspectives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Few parents (5.3%) were aware of the guideline before the survey. Cluster analysis identified three subgroups: Guideline Skeptics (34%; broadly disagreed), Selective Supporters (28%; mostly agreed but opposed medications and surgery), and Guideline Supporters (38%; broadly agreed). Higher parental BMI predicted lower agreement (<i>β</i> = −0.20, <i>p</i> = 0.018). Qualitative findings added nuance to parents' preference for lifestyle changes, highlighted concerns about mental health and eating disorders, and emphasized parental responsibility in the development and treatment of obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Parental agreement with the guideline varies widely. While most support behavioral treatment, many express concerns about medications and surgery, and a subset of “Guideline Skeptics” reject core principles such as the use of BMI. Tailored implementation strategies are needed to address these diverse views.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebecca Puhl, Sandra Hassink, Julia Lischka, Gabriel Torbahn, Susanne Ring-Dimitriou, Caroline Braet, Elpis Vlachopapadopoulou, Teodora Handjieva-Darlenska, Andrea Vania, Edyta Łuszczki, Dénes Attila Molnár, David Thivel, Daniel Weghuber, Paulina Nowicka
Parental communication plays a critical role in weight-related health of children and adolescents and requires a balanced, thoughtful and supportive approach. The European Childhood Obesity Group (ECOG) convened a panel of experts to discuss the topic of parental communication in the prevention and treatment of child and adolescent obesity, as summarised in this statement. Parental concern about weight is evident, but the lack of parental knowledge about obesity, the impact of weight bias and stigma on their children and adolescents' health behaviours, and the influences of culture, media, and advertising all make communication challenging and problematic for many families. Parents need support and skill building in order to provide a communication environment that is healthy and accepting. Healthcare professionals can model healthy communication styles by focusing on health, building family strengths and supports, asking youth about what words they prefer using to discuss their weight, and acknowledging the multifactorial causes of obesity that reside in the socioecological environment. While parental communication offers a powerful platform for promoting healthy behaviours in youth, it must be handled with care to avoid the harms of stigmatisation and oversimplification of obesity as a reflection of individual lifestyle choices. With appropriate tools, knowledge, skills, and support, parents can be better equipped to engage in supportive dialogue that empowers their children and promotes their health and wellbeing.
{"title":"Parental Communication in the Prevention and Treatment of Child and Adolescent Obesity: A Position Statement of the European Childhood Obesity Group","authors":"Rebecca Puhl, Sandra Hassink, Julia Lischka, Gabriel Torbahn, Susanne Ring-Dimitriou, Caroline Braet, Elpis Vlachopapadopoulou, Teodora Handjieva-Darlenska, Andrea Vania, Edyta Łuszczki, Dénes Attila Molnár, David Thivel, Daniel Weghuber, Paulina Nowicka","doi":"10.1111/ijpo.70052","DOIUrl":"10.1111/ijpo.70052","url":null,"abstract":"<div>\u0000 \u0000 <p>Parental communication plays a critical role in weight-related health of children and adolescents and requires a balanced, thoughtful and supportive approach. The European Childhood Obesity Group (ECOG) convened a panel of experts to discuss the topic of parental communication in the prevention and treatment of child and adolescent obesity, as summarised in this statement. Parental concern about weight is evident, but the lack of parental knowledge about obesity, the impact of weight bias and stigma on their children and adolescents' health behaviours, and the influences of culture, media, and advertising all make communication challenging and problematic for many families. Parents need support and skill building in order to provide a communication environment that is healthy and accepting. Healthcare professionals can model healthy communication styles by focusing on health, building family strengths and supports, asking youth about what words they prefer using to discuss their weight, and acknowledging the multifactorial causes of obesity that reside in the socioecological environment. While parental communication offers a powerful platform for promoting healthy behaviours in youth, it must be handled with care to avoid the harms of stigmatisation and oversimplification of obesity as a reflection of individual lifestyle choices. With appropriate tools, knowledge, skills, and support, parents can be better equipped to engage in supportive dialogue that empowers their children and promotes their health and wellbeing.</p>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raphaëlle Jacob, Andrea C. Buchholz, Gerarda Darlington, Alison M. Duncan, Lori Ann Vallis, Jean-Philippe Chaput, Angela Annis, Madeline Nixon, Jennifer D. Irwin, Don Morrow, David W. L. Ma, Jess Haines
Background
To prevent the development of obesity and related comorbidities, interventions must begin early in life. This study aimed to assess the impact of a home-based obesity prevention intervention on children's and parents' body mass index (BMI).
Methods
The Guelph Family Health Study is a randomised controlled trial of a 6-month obesity prevention intervention aimed at establishing healthful household routines regarding family meals, children's screen time, physical activity and sleep among 285 families with preschool-aged children. The control group received 6 emails on child health behaviours. The analytic sample included 376 children (3.6 ± 1.3 years old, 20.2% at risk for overweight, 8.2% with overweight/obesity) and 481 parents (58.2% with overweight/obesity).
Results
Compared to controls, the intervention had no significant impact on children's or parents' BMI at post-intervention and 1 year after the intervention. Children in both the intervention and control groups had a non-significant decrease in BMI from baseline to post-intervention [intervention; −0.23 kg/m2 (95% CI, −0.46, 0.002); control; −0.17 kg/m2 (95% CI, −0.40, 0.06)] and from baseline to 1-year follow-up [intervention, −0.29 kg/m2 (95% CI, −0.67, 0.08); control, −0.06 kg/m2 (95% CI, −0.42, 0.30)].
Conclusions
Compared to controls, this home-based obesity prevention intervention had no significant impact on children's or parents' BMI immediately after the intervention or after 1 year of follow-up, indicating that the intervention had no additional effect compared to the control group on children's or parents' BMI over time. Future data collection phases will allow for the examination of the intervention effect on BMI as children age.
Trial Registration
This study is registered at clinicaltrial.gov identifier: NCT02939261
{"title":"Impact of a Home-Based Obesity Prevention Intervention on Children's and Parents' BMI: Findings From the Guelph Family Health Study Randomised Controlled Trial","authors":"Raphaëlle Jacob, Andrea C. Buchholz, Gerarda Darlington, Alison M. Duncan, Lori Ann Vallis, Jean-Philippe Chaput, Angela Annis, Madeline Nixon, Jennifer D. Irwin, Don Morrow, David W. L. Ma, Jess Haines","doi":"10.1111/ijpo.70062","DOIUrl":"10.1111/ijpo.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To prevent the development of obesity and related comorbidities, interventions must begin early in life. This study aimed to assess the impact of a home-based obesity prevention intervention on children's and parents' body mass index (BMI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Guelph Family Health Study is a randomised controlled trial of a 6-month obesity prevention intervention aimed at establishing healthful household routines regarding family meals, children's screen time, physical activity and sleep among 285 families with preschool-aged children. The control group received 6 emails on child health behaviours. The analytic sample included 376 children (3.6 ± 1.3 years old, 20.2% at risk for overweight, 8.2% with overweight/obesity) and 481 parents (58.2% with overweight/obesity).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to controls, the intervention had no significant impact on children's or parents' BMI at post-intervention and 1 year after the intervention. Children in both the intervention and control groups had a non-significant decrease in BMI from baseline to post-intervention [intervention; −0.23 kg/m<sup>2</sup> (95% CI, −0.46, 0.002); control; −0.17 kg/m<sup>2</sup> (95% CI, −0.40, 0.06)] and from baseline to 1-year follow-up [intervention, −0.29 kg/m<sup>2</sup> (95% CI, −0.67, 0.08); control, −0.06 kg/m<sup>2</sup> (95% CI, −0.42, 0.30)].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared to controls, this home-based obesity prevention intervention had no significant impact on children's or parents' BMI immediately after the intervention or after 1 year of follow-up, indicating that the intervention had no additional effect compared to the control group on children's or parents' BMI over time. Future data collection phases will allow for the examination of the intervention effect on BMI as children age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study is registered at clinicaltrial.gov identifier: NCT02939261</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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