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Geographic and ethnic inequalities in total and central obesity, and physical fitness among preschool children: Insights from the PREFIT project 学龄前儿童总体肥胖和中心肥胖以及身体健康的地理和种族不平等:来自PREFIT项目的见解。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-13 DOI: 10.1111/ijpo.70021
Cristina Cadenas-Sanchez, Jorge R. Fernández-Santos, Mairena Sánchez-López, Natalia García-Corada, Diego Moliner-Urdiales, Nuria Romero-Parra, Manuel A. Rodriguez Perez, Pere Palou, Cecilia Dorado-García, German Vicente-Rodríguez, Francisco B. Ortega, David Jiménez-Pavón

Background and objectives

Obesity and physical fitness are known to be influenced by various geographic factors and ethnicity in children. However, there is limited evidence on the level to which these factors can influence very early in life, at preschool age. This study aimed to describe and compare total and central obesity and physical fitness according to geographic factors and ethnicity in preschoolers.

Methods

This cross-sectional study included 3179 preschoolers (4.6 ± 0.9y, 52.8% boys). Geographic factors (location and type of area: rural/urban) were assessed based on the school setting, while ethnicity was determined through parental self-report. Total and central obesity and physical fitness (cardiorespiratory fitness, muscular strength, speed-agility, balance) were assessed using the PREFIT battery.

Results

Preschoolers from southern regions of Spain presented higher total obesity along with lower performance in cardiorespiratory fitness and lower-limb muscular strength compared to their northern peers (p ≤ 0.017). However, they demonstrated greater levels of upper-limb muscular strength and balance (p < 0.001). Preschoolers from rural areas of Spain showed higher central obesity but better fitness performance compared to those from urban areas (p ≤ 0.004). White and African preschoolers showed lower levels of total and central obesity than Latin preschoolers (p ≤ 0.003) and performed better in upper-limb muscular strength and speed–agility compared to Asian or Latin preschoolers (p ≤ 0.037).

Conclusion

This study highlights significant physical health inequalities among preschoolers based on geographical factors and ethnic backgrounds. These findings underscore the need for targeted public health strategies to address socioeconomic and environmental determinants of early-life health disparities.

背景和目的:儿童的肥胖和身体健康受到各种地理因素和种族的影响。然而,关于这些因素在生命早期,即学龄前影响程度的证据有限。本研究旨在根据地理因素和种族描述和比较学龄前儿童的总体和中心肥胖和身体健康。方法:对3179名学龄前儿童(4.6±0.9岁,男孩占52.8%)进行横断面研究。地理因素(位置和区域类型:农村/城市)根据学校环境进行评估,而种族则通过父母自我报告确定。使用PREFIT电池评估总肥胖和中心性肥胖以及身体健康(心肺健康、肌肉力量、速度敏捷性、平衡)。结果:与北部地区相比,西班牙南部地区的学龄前儿童总体肥胖程度较高,心肺健康和下肢肌肉力量表现较差(p≤0.017)。然而,他们表现出更高水平的上肢肌肉力量和平衡(p结论:这项研究强调了基于地理因素和种族背景的学龄前儿童之间显著的身体健康不平等。这些发现强调需要制定有针对性的公共卫生战略,以解决造成生命早期健康差异的社会经济和环境决定因素。
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引用次数: 0
Adverse childhood experiences and appetitive traits in adolescence: A prospective cohort study 不良童年经历与青春期食欲特征:一项前瞻性队列研究。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-08 DOI: 10.1111/ijpo.70022
Alexandra Costa, Sílvia Fraga, Marion M. Hetherington, Andreia Oliveira

Objective

To explore the association between adverse childhood experiences (ACEs) and appetitive traits in adolescence.

Methods

Participants were 4118 children from the Generation XXI cohort. ACEs were assessed at age 10 with a self-administered questionnaire covering 15 different experiences and analysed by exposure categories (0, 1–3, 4–5 and ≥6) and dimensions identified through component analysis. Appetitive traits at age 13 were measured with the Children's Eating Behaviour Questionnaire, completed by parents. Multivariable linear regression analysis, adjusted for sociodemographic factors, was used.

Results

Ninety-six percent reported at least one ACE, with 26% reporting ≥6. Those who reported at least one ACE had higher scores on food approach traits, indicative of an avid appetite. A dose–response relationship was observed between the number of ACEs and Food Responsiveness, Emotional Overeating and Desire to Drink. Participants with ≥6 ACEs scored higher on Enjoyment of Food (β̂= 0.19, 95% confidence interval [CI] [0.06, 0.31]) and Emotional Undereating (β̂= 0.13, 95% CI [0.01, 0.25]), and lower on Slowness in Eating (β̂ = −0.19, 95%CI [−0.32, −0.06]). Analysis by ACEs dimensions revealed more consistent associations with food approach traits.

Conclusion

Greater ACE exposure was associated with appetitive traits that increase obesity risk, suggesting that these traits may contribute to explaining the association between ACEs and obesity.

目的:探讨不良童年经历与青少年食欲特征的关系。方法:研究对象为来自21代队列的4118名儿童。在10岁时通过一份涵盖15种不同经历的自填问卷对ace进行评估,并根据暴露类别(0、1-3、4-5和≥6)和成分分析确定的维度进行分析。13岁时的食欲特征由父母填写的儿童饮食行为问卷进行测量。采用多变量线性回归分析,调整社会人口因素。结果:96%的患者报告至少一次ACE, 26%的患者报告至少一次ACE% reporting ≥6. Those who reported at least one ACE had higher scores on food approach traits, indicative of an avid appetite. A dose-response relationship was observed between the number of ACEs and Food Responsiveness, Emotional Overeating and Desire to Drink. Participants with ≥6 ACEs scored higher on Enjoyment of Food ( β ̂ $$ hat{beta } $$ = 0.19, 95% confidence interval [CI] [0.06, 0.31]) and Emotional Undereating ( β ̂ $$ hat{beta} $$ = 0.13, 95% CI [0.01, 0.25]), and lower on Slowness in Eating ( β ̂ $$ hat{beta} $$  = -0.19, 95%CI [-0.32, -0.06]). Analysis by ACEs dimensions revealed more consistent associations with food approach traits.Conclusion: Greater ACE exposure was associated with appetitive traits that increase obesity risk, suggesting that these traits may contribute to explaining the association between ACEs and obesity.
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引用次数: 0
Associations between healthy eating index and anthropometric outcomes in multiethnic elementary-aged children 多民族小学年龄儿童健康饮食指数与人体测量结果之间的关系
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-08 DOI: 10.1111/ijpo.70018
Amanda M. Jústiz, Matthew J. Landry, Jaimie N. Davis

Introduction

High adiposity in children can predict cardiometabolic risk in adulthood. This study investigated if changes in dietary quality, measured by the Healthy Eating Index (HEI), are associated with changes in anthropometric measurements in children.

Methods

This secondary analysis used data from TX Sprouts, a cluster randomized controlled trial that investigated the effects of a 1-year school nutrition program on child diet and obesity. 24-hour dietary recalls were used to measure HEI-2020 at baseline and post-intervention. Anthropometric outcomes were BMI, waist circumference, and body fat percentage via bioelectrical impedance. Linear regression models assessed associations between changes in HEI-2020 total and component scores and anthropometrics.

Results

Participants (n = 424) were 53% male, 56% Hispanic, and the average age was 9.3 years. A 10-point increase in total HEI-2020 score was associated with a 0.4% (95% CI: 0.1%–0.6%) decrease in body fat percentage. Increases in whole grain and decreases in refined grain component scores were associated with decreases in body fat percentage. Changes in total or component scores were not associated with changes in BMI, BMI-Z, or waist circumference.

Conclusion

This study found associations between increased diet quality and decreased body fat percentage in a primarily low-income, multi-ethnic population of children.

儿童的高肥胖可以预测成年后的心脏代谢风险。本研究调查了以健康饮食指数(HEI)衡量的饮食质量的变化是否与儿童人体测量值的变化有关。方法:这项二次分析使用了来自TX芽菜的数据,这是一项随机对照试验,调查了1年学校营养计划对儿童饮食和肥胖的影响。24小时饮食回顾用于测量基线和干预后的HEI-2020。人体测量结果是通过生物电阻抗测量BMI、腰围和体脂率。线性回归模型评估了HEI-2020总分和分值变化与人体测量学之间的关系。结果:参与者(n = 424) 53%为男性,56%为西班牙裔,平均年龄为9.3岁。HEI-2020总分每增加10分,体脂率就会下降0.4% (95% CI: 0.1%-0.6%)。全谷物含量的增加和精制谷物含量的减少与体脂率的降低有关。总得分或成分得分的变化与BMI、BMI- z或腰围的变化无关。结论:本研究发现,在低收入、多种族的儿童中,饮食质量的提高与体脂率的降低存在关联。
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引用次数: 0
The correlation of apolipoprotein B and apolipoprotein A1 with metabolic dysfunction-associated steatotic liver disease in children and adolescents with obesity 载脂蛋白B和载脂蛋白A1与肥胖儿童和青少年代谢功能障碍相关的脂肪变性肝病的相关性
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-06 DOI: 10.1111/ijpo.70017
Xiao-Yan Shi, Ya-Kun Liu, Yan Chen, Zhi-Ying Jiang, Meng-Xuan Ye, Jian Wang

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prevalent liver condition in children and teenagers with obesity. Unfortunately, there is no standardized treatment.

Objective

To examine the connection between apolipoprotein B (apoB), apolipoprotein A1 (apoA1), and the apoB/apoA1 ratio with the occurrence of MASLD in this population.

Methods

A retrospective study was made on children and adolescents with obesity in a children's hospital between the period 2020 and 2022. Anthropometric data, ultrasound results, and blood biochemistry were analysed to assess the connection between apoB, apoA1, and the presence of MASLD.

Results

Of the 916 participants included, 313 were diagnosed with MASLD. The level of serum apoB reflected a substantial dose–response correlation with the odds of having MASLD. When apoB levels exceeded the 50th percentile, the risk increased significantly, and at the 95th percentile, the odds were 4.83 times higher than at the 50th percentile (95% CI: 2.02–11.56). The ratio of apoB/apoA1 at the 95th percentile was connected to a 2.41-fold higher prevalence compared to the 50th percentile (95% CI: 1.33–4.37). No significant correlation was found between the levels of apoA1 and MASLD prevalence.

Conclusion

Elevated levels of apoB and the apoB/apoA1 ratio have been strongly connected to increased MASLD prevalence in children and adolescents with obesity; hence, signifying their potential usefulness as biomarkers for early detection and intervention.

背景:代谢功能障碍相关的脂肪变性肝病(MASLD)已成为儿童和青少年肥胖的一种普遍肝脏疾病。不幸的是,没有标准化的治疗方法。目的:探讨载脂蛋白B (apoB)、载脂蛋白A1 (apoA1)及载脂蛋白/载脂蛋白A1比值与该人群MASLD发生的关系。方法:对某儿童医院2020 ~ 2022年收治的肥胖儿童和青少年进行回顾性研究。对人体测量数据、超声结果和血液生化进行分析,以评估载脂蛋白ob、载脂蛋白a1与MASLD存在之间的联系。结果:在纳入的916名参与者中,313名被诊断为MASLD。血清载脂蛋白水平反映了与MASLD发生率的剂量-反应相关性。当载脂蛋白ob水平超过第50百分位时,风险显著增加,在第95百分位时,风险是第50百分位的4.83倍(95% CI: 2.02-11.56)。与第50百分位相比,第95百分位的apoB/apoA1比值与2.41倍的患病率相关(95% CI: 1.33-4.37)。apoA1水平与MASLD患病率之间未发现显著相关性。结论:apoB和apoB/apoA1比值的升高与肥胖儿童和青少年MASLD患病率的增加密切相关;因此,表明它们作为早期检测和干预的生物标志物的潜在用途。
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引用次数: 0
Investigating the association between parental educational status and offspring obesity risk using the Japan Environment and Children's Study 利用日本环境与儿童研究调查父母受教育程度与子女肥胖风险之间的关系。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-06 DOI: 10.1111/ijpo.70019
Masahiro Noda, Satomi Yoshida, Tetsuya Tsuchida, Masato Takeuchi, Chihiro Kawakami, Koji Kawakami, Shuichi Ito, The Japan Environment and Children's Study Group

Background

Previous studies have demonstrated an inverse relationship between socioeconomic status and childhood obesity in affluent nations, with parental education as a key factor. However, the meaning of socioeconomic indicators may vary by race and country, and research on this topic in Asian countries is limited.

Objectives

We investigated the association between parents' educational status and childhood obesity in Japan.

Methods

We utilized data from Japan's birth cohort, recruiting participants from 2011 to 2014, and included 49 564 children. Parental educational status was categorized into four groups: both parents with lower education (LM-LF), mothers with higher education and fathers with lower education (HM-LF), mothers with lower education and fathers with higher education (LM-HF), and both parents with higher education (HM-HF). Multivariable logistic regression analyzed the association between parental education and overweight/obesity among 4-year-old children.

Results

Of the participants, 17.9%, 16.9%, 16.2% and 15.4% were overweight/obese; and 5.5%, 4.6%, 4.4% and 3.8% were obese in LM-LF, HM-LF, LM-HF and HM-HF groups, respectively. When the reference group was defined as children born to parents with HM-HF, the adjusted odds ratios for overweight/obesity in LM-LF, HM-LF and LM-HF were 1.13 (95% confidence intervals [CI]: 1.06–1.21), 1.08 (95% CI: 1.01–1.15) and 1.03 (95% CI: 0.95–1.12); and those for obesity were 1.34 (95% CI: 1.20–1.50), 1.16 (95% CI: 1.04–1.31) and 1.11 (95% CI: 0.96–1.28), respectively.

Conclusions

Lower educational status in both parents was associated with overweight/obesity among 4-year-old children in Japan. Public policies might target parents with lower education to prevent childhood obesity.

背景:以往的研究表明,在富裕国家,社会经济地位与儿童肥胖呈反比关系,父母教育是一个关键因素。然而,社会经济指标的含义可能因种族和国家而异,亚洲国家对这一主题的研究有限。目的:调查日本父母受教育程度与儿童肥胖的关系。方法:我们利用日本出生队列的数据,从2011年到2014年招募参与者,包括49564名儿童。父母受教育程度分为父母双方受教育程度较低(LM-LF)、母亲受教育程度较高且父亲受教育程度较低(HM-LF)、母亲受教育程度较低且父亲受教育程度较高(LM-HF)和父母双方受教育程度较高(HM-HF) 4组。多变量logistic回归分析了父母教育与4岁儿童超重/肥胖的关系。结果:17.9%、16.9%、16.2%和15.4%的参与者超重/肥胖;LM-LF组、HM-LF组、LM-HF组和HM-HF组肥胖率分别为5.5%、4.6%、4.4%和3.8%。当参照组定义为父母患有hf的儿童时,LM-LF、HM-LF和LM-HF的超重/肥胖校正优势比分别为1.13(95%可信区间[CI]: 1.06-1.21)、1.08 (95% CI: 1.01-1.15)和1.03 (95% CI: 0.95-1.12);肥胖的死亡率分别为1.34 (95% CI: 1.20-1.50)、1.16 (95% CI: 1.04-1.31)和1.11 (95% CI: 0.96-1.28)。结论:父母双方教育程度较低与日本4岁儿童超重/肥胖有关。公共政策可能会针对受教育程度较低的父母来预防儿童肥胖。
{"title":"Investigating the association between parental educational status and offspring obesity risk using the Japan Environment and Children's Study","authors":"Masahiro Noda,&nbsp;Satomi Yoshida,&nbsp;Tetsuya Tsuchida,&nbsp;Masato Takeuchi,&nbsp;Chihiro Kawakami,&nbsp;Koji Kawakami,&nbsp;Shuichi Ito,&nbsp;The Japan Environment and Children's Study Group","doi":"10.1111/ijpo.70019","DOIUrl":"10.1111/ijpo.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous studies have demonstrated an inverse relationship between socioeconomic status and childhood obesity in affluent nations, with parental education as a key factor. However, the meaning of socioeconomic indicators may vary by race and country, and research on this topic in Asian countries is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We investigated the association between parents' educational status and childhood obesity in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We utilized data from Japan's birth cohort, recruiting participants from 2011 to 2014, and included 49 564 children. Parental educational status was categorized into four groups: both parents with lower education (LM-LF), mothers with higher education and fathers with lower education (HM-LF), mothers with lower education and fathers with higher education (LM-HF), and both parents with higher education (HM-HF). Multivariable logistic regression analyzed the association between parental education and overweight/obesity among 4-year-old children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the participants, 17.9%, 16.9%, 16.2% and 15.4% were overweight/obese; and 5.5%, 4.6%, 4.4% and 3.8% were obese in LM-LF, HM-LF, LM-HF and HM-HF groups, respectively. When the reference group was defined as children born to parents with HM-HF, the adjusted odds ratios for overweight/obesity in LM-LF, HM-LF and LM-HF were 1.13 (95% confidence intervals [CI]: 1.06–1.21), 1.08 (95% CI: 1.01–1.15) and 1.03 (95% CI: 0.95–1.12); and those for obesity were 1.34 (95% CI: 1.20–1.50), 1.16 (95% CI: 1.04–1.31) and 1.11 (95% CI: 0.96–1.28), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Lower educational status in both parents was associated with overweight/obesity among 4-year-old children in Japan. Public policies might target parents with lower education to prevent childhood obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity ObMetrics:一个闪亮的应用程序,以协助代谢综合征评估在儿童肥胖。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-05-05 DOI: 10.1111/ijpo.70016
Álvaro Torres-Martos, Francisco Requena, Guadalupe López-Rodríguez, Jhazmin Hernández-Cabrera, Marcos Galván, Elizabeth Solís-Pérez, Susana Romo-Tello, José Luis Jasso-Medrano, Jenny Vilchis-Gil, Miguel Klünder-Klünder, Gloria Martínez-Andrade, María Elena Acosta Enríquez, Juan Carlos Aristizabal, Alberto Ramírez-Mena, Nikos Stratakis, Mireia Bustos-Aibar, Ángel Gil, Mercedes Gil-Campos, Gloria Bueno, Rosaura Leis, Jesús Alcalá-Fdez, Concepción María Aguilera, Augusto Anguita-Ruiz

Objective

To introduce ObMetrics, a free and user-friendly Shiny app that simplifies the calculation, data analysis, and interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies of paediatric populations. We illustrate its usefulness using ethnically different populations in a comparative study of prevalence across cohorts and definitions.

Methods

We conducted a case study using data from two ethnically diverse paediatric populations: a Hispanic-American cohort (N = 1759) and a Hispanic-European cohort (N = 2411). Using ObMetrics, we computed MetS classifications (Cook, Zimmet, Ahrens) and component-specific z-scores for each participant to compare prevalences.

Results

The analysis revealed significant heterogeneity in MetS prevalence across different definitions and cohorts. According to Cook, Zimmet, and Ahrens's definitions, MetS prevalence in children with obesity was 25%, 12%, and 48%, respectively, in the Hispanic-European cohort, and 38%, 27%, and 66% in the Hispanic-American cohort. Calculating component-specific z-scores in each cohort also highlighted ethnic-specific differences in lipid metabolism and blood pressure. By automating these complex calculations, ObMetrics considerably reduced analysis time and minimised the potential for errors.

Conclusion

ObMetrics proved to be a powerful tool for paediatric research, generating detailed reports on the prevalence of MetS and its components based on various definitions and reference standards. Our case study further provides valuable insights into the challenges of characterising metabolic health in paediatric populations. Future efforts should focus on developing unified consensus guidelines for paediatric MetS. Meanwhile, ObMetrics enables earlier identification and targeted intervention for high-risk children and adolescents.

目的:介绍一款免费且用户友好的Shiny应用程序ObMetrics,该应用程序可以根据儿科人群流行病学研究中的多种定义简化代谢综合征(MetS)结果的计算、数据分析和解释。我们使用不同种族的人群在跨队列和定义的患病率比较研究中说明了它的有用性。方法:我们使用来自两个不同种族的儿科人群的数据进行了一项病例研究:西班牙裔美国人队列(N = 1759)和西班牙裔欧洲人队列(N = 2411)。使用ObMetrics,我们计算met分类(Cook, Zimmet, Ahrens)和每个参与者特定组件的z分数来比较患病率。结果:分析显示MetS在不同定义和队列中的患病率存在显著的异质性。根据Cook、Zimmet和Ahrens的定义,肥胖儿童的met患病率在西班牙裔欧洲人群中分别为25%、12%和48%,在西班牙裔美国人群中分别为38%、27%和66%。在每个队列中计算组件特异性z分数也突出了脂质代谢和血压的种族特异性差异。通过自动化这些复杂的计算,ObMetrics大大减少了分析时间,并最大限度地减少了错误的可能性。结论:ObMetrics被证明是儿科研究的有力工具,根据各种定义和参考标准,生成关于MetS及其组成部分的详细报告。我们的案例研究进一步为描述儿科人群代谢健康的挑战提供了有价值的见解。未来的努力应侧重于制定统一共识的儿科MetS指南。同时,ObMetrics能够对高危儿童和青少年进行早期识别和有针对性的干预。
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引用次数: 0
Associations of adiponectin concentrations from birth until late adolescence with insulin resistance 从出生到青春期晚期脂联素浓度与胰岛素抵抗的关系。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-04-23 DOI: 10.1111/ijpo.70015
Yeran Lee, Soren Harnois-Leblanc, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert

Introduction

We investigated associations of adiponectin concentrations from birth to adolescence with insulin resistance in late adolescence using data from Project Viva prospective birth cohort (Eastern Massachusetts, 1999-2002).

Methods

We conducted multivariable linear regression models between adiponectin (internal z-scores) at birth, early childhood, mid-childhood, early and late adolescence and insulin resistance in late adolescence with the homeostasis model for insulin resistance (HOMA-IR).

Results

In 468 children (52% female, 59% Non–Hispanic White), we observed inverse associations of adiponectin z-scores in mid–childhood (–0.16, 95% CI: –0.33, 0.01), early adolescence (–0.19, 95% CI: –0.37, –0.01) and late adolescence (–0.40, 95% CI: –0.57, –0.23) with HOMA-IR in late adolescence; these associations were attenuated after accounting for BMI z-score. When stratified by sex, we observed these associations in males, while estimates were more modest in females.

Conclusion

Overall, starting in mid-childhood, lower adiponectin concentrations were linked with higher insulin resistance in late adolescence, with associations apparent mostly in males.

前言:我们研究了从出生到青春期脂联素浓度与青春期后期胰岛素抵抗的关系,使用的数据来自Viva项目前瞻性出生队列(马萨诸塞州东部,1999-2002)。方法:采用胰岛素抵抗稳态模型(HOMA-IR)对出生时、幼儿期、幼儿期中期、青春期早期和晚期的脂联素(内部z分数)与青春期晚期的胰岛素抵抗进行多变量线性回归模型。结果:在468名儿童(52%为女性,59%为非西班牙裔白人)中,我们观察到青春期中期(-0.16,95% CI: -0.33, 0.01)、青春期早期(-0.19,95% CI: -0.37, -0.01)和青春期晚期(-0.40,95% CI: -0.57, -0.23)的脂联素z-评分与青春期晚期HOMA-IR呈负相关;在计入BMI z-score后,这些关联减弱。当按性别分层时,我们在男性中观察到这些关联,而在女性中估计更为温和。结论:总的来说,从童年中期开始,较低的脂联素浓度与青春期后期较高的胰岛素抵抗有关,这种联系在男性中最为明显。
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引用次数: 0
Cross-sectional associations between Mediterranean diet and body composition in preschool children. CORAL study 地中海饮食与学龄前儿童身体成分的横断面关联。珊瑚的研究。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-04-21 DOI: 10.1111/ijpo.70014
Alicia Larruy-García, María L Miguel-Berges, Isabel Rueda-De Torre, Belén Pastor-Villaescusa, Rosaura Leis, Nancy Babio, Santiago Navas-Carretero, Dolores Corella, Alejandra Pérez, Mercedes Gil-Campos, Rosaura Picáns-Leis, Jesús Garcia-Gavilán, Paloma Flores-Barrante, J. Alfredo Martínez, Francisco Jesús Llorente-Cantarero, Rocío Vázquez-Cobela, Indira Paz-Graniel, Alelí M. Ayala-Marín, José Manuel Jurado-Castro, María José de la Torre-Aguilar, Irina Gheorghita, Luis A. Moreno, Pilar De Miguel-Etayo, the CORAL Study group

Background

Overweight and obesity in children are rising globally, and the Mediterranean diet may help reduce obesity and related diseases.

Objective

To assess the association between adherence to the Mediterranean diet and body composition in Spanish preschool children.

Methods

This study included 1218 children aged 3–6 years from the CORALS cohort. Mediterranean diet adherence was evaluated using the validated MED4CHILD and COME-Kids F&B-FQ questionnaires. Body composition measurements included weight, height, waist circumference, BMI, Fat Mass (FM), Fat-Free Mass Index (FFMI), and Waist-to-Height ratio (WtHR). Multivariate regression and ANCOVA were used to examine associations, adjusting for factors like age, physical activity, and energy intake. We also performed a Cohen's d analysis to assess effect size.

Results

Adherence to the Mediterranean diet was associated with more favourable body composition in children. Specifically, both the MED4CHILD score and the COME-Kids-derived score showed significant associations with BMI, FFMI, and Waist-to-Height ratio, showing differences by sex. Children who adhered to the Mediterranean diet exhibited lower BMI and higher fat-free mass, and a more favourable waist-to-height ratio. Additionally, although some measures showed weaker associations, all analyses highlighted a trend towards improved body composition with higher adherence. Cohen's d analysis showed small to moderate effect sizes.

Conclusion

Adherence to the Mediterranean diet was significantly linked to favorable body composition indices in Spanish children, highlighting the importance of promoting healthy dietary patterns to prevent overweight and obesity.

背景:儿童超重和肥胖在全球范围内呈上升趋势,地中海饮食可能有助于减少肥胖和相关疾病。目的:评估西班牙学龄前儿童坚持地中海饮食与身体成分之间的关系。方法:本研究包括1218名年龄在3-6岁的儿童。采用经验证的MED4CHILD和COME-Kids F&B-FQ问卷评估地中海饮食依从性。身体组成测量包括体重、身高、腰围、BMI、脂肪质量(FM)、无脂质量指数(FFMI)和腰高比(WtHR)。多变量回归和ANCOVA用于检验相关性,调整了年龄、身体活动和能量摄入等因素。我们还进行了科恩分析来评估效应大小。结果:坚持地中海饮食与儿童更有利的身体组成有关。具体而言,MED4CHILD评分和come - kids衍生评分均与BMI、FFMI和腰高比存在显著相关性,且存在性别差异。坚持地中海饮食的儿童表现出较低的身体质量指数和较高的无脂质量,以及更有利的腰高比。此外,尽管一些测量显示相关性较弱,但所有分析都强调了改善身体成分和提高依从性的趋势。科恩的分析显示了小到中等的效应。结论:坚持地中海饮食与西班牙儿童良好的身体成分指数显著相关,强调了促进健康饮食模式以预防超重和肥胖的重要性。
{"title":"Cross-sectional associations between Mediterranean diet and body composition in preschool children. CORAL study","authors":"Alicia Larruy-García,&nbsp;María L Miguel-Berges,&nbsp;Isabel Rueda-De Torre,&nbsp;Belén Pastor-Villaescusa,&nbsp;Rosaura Leis,&nbsp;Nancy Babio,&nbsp;Santiago Navas-Carretero,&nbsp;Dolores Corella,&nbsp;Alejandra Pérez,&nbsp;Mercedes Gil-Campos,&nbsp;Rosaura Picáns-Leis,&nbsp;Jesús Garcia-Gavilán,&nbsp;Paloma Flores-Barrante,&nbsp;J. Alfredo Martínez,&nbsp;Francisco Jesús Llorente-Cantarero,&nbsp;Rocío Vázquez-Cobela,&nbsp;Indira Paz-Graniel,&nbsp;Alelí M. Ayala-Marín,&nbsp;José Manuel Jurado-Castro,&nbsp;María José de la Torre-Aguilar,&nbsp;Irina Gheorghita,&nbsp;Luis A. Moreno,&nbsp;Pilar De Miguel-Etayo,&nbsp;the CORAL Study group","doi":"10.1111/ijpo.70014","DOIUrl":"10.1111/ijpo.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Overweight and obesity in children are rising globally, and the Mediterranean diet may help reduce obesity and related diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the association between adherence to the Mediterranean diet and body composition in Spanish preschool children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 1218 children aged 3–6 years from the CORALS cohort. Mediterranean diet adherence was evaluated using the validated MED4CHILD and COME-Kids F&amp;B-FQ questionnaires. Body composition measurements included weight, height, waist circumference, BMI, Fat Mass (FM), Fat-Free Mass Index (FFMI), and Waist-to-Height ratio (WtHR). Multivariate regression and ANCOVA were used to examine associations, adjusting for factors like age, physical activity, and energy intake. We also performed a Cohen's d analysis to assess effect size.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Adherence to the Mediterranean diet was associated with more favourable body composition in children. Specifically, both the MED4CHILD score and the COME-Kids-derived score showed significant associations with BMI, FFMI, and Waist-to-Height ratio, showing differences by sex. Children who adhered to the Mediterranean diet exhibited lower BMI and higher fat-free mass, and a more favourable waist-to-height ratio. Additionally, although some measures showed weaker associations, all analyses highlighted a trend towards improved body composition with higher adherence. Cohen's d analysis showed small to moderate effect sizes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adherence to the Mediterranean diet was significantly linked to favorable body composition indices in Spanish children, highlighting the importance of promoting healthy dietary patterns to prevent overweight and obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between chrononutrition and cardiometabolic risk in prepubertal children with and without excess weight 有无超重的青春期前儿童的时间营养与心脏代谢风险之间的关系。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-03-26 DOI: 10.1111/ijpo.70013
Beatriz Louise Costa Themistocles, Fernanda Mussi Gazolla Jannuzzi, Alexandra Maria Monteiro Grisolia, Elisabeth Machado, Isabel Rey Madeira, Eliete Bouskela, Paulo Farinatti, Cecilia Lacroix de Oliveira, Paulo Ferrez Collett-Solberg

Background

Chrononutrition may affect childhood cardiometabolic health. Understanding this relationship may be crucial for managing paediatric obesity.

Objective

To investigate the relationship between chrononutrition and cardiometabolic risk factors in prepubertal children.

Methods

This cross-sectional study included 93 participants (50 males, 5–12 years), categorized as healthy weight (HW, n = 34), overweight (OV, n = 10), obese (OB, n = 23) and severe obesity (SOB, n = 26). 24-h dietary recalls assessed participants' caloric and energy substrate intake, analysed for the morning (until 11 am), afternoon (11 am to 6 pm), night (after 6:01 pm), and total daily intake. Cardiometabolic risk was evaluated through fasting glycemia, insulinemia, HOMA-IR, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides (TG), and ultrasound analysis of abdominal fat (AF) and carotid intima-media thickness (CIMT).

Results

OB and SOB subjects had significantly higher (p < 0.001) insulinemia, HOMA-IR, TG, and AF, compared to HW subjects. SOB subjects showed significantly higher (p < 0.05) total daily protein intake than HW subjects. Considering the total sample, morning carbohydrate intake was inversely associated (p < 0.05; r = −0.21) with TC. Afternoon total calories (r = −0.33), carbohydrate (r = −0.35), and lipid (r = −0.23) intake were inversely associated (p < 0.05) with insulinemia. Higher lipid intake was linked to lower HDL-cholesterol (r = −0.22), while protein intake was linked to higher BMI Z-Score (r = 0.25) and glycemia (r = 0.23). Nighttime protein intake was positively correlated (p < 0.05) with BMI Z-Score (r = 0.24), insulinemia (r = 0.24), HOMA-IR (r = 0.27), TG (r = 0.25), AF (r = 0.25), and CIMT (r = 0.27).

Conclusion

Higher morning and afternoon carbohydrate intake, increased afternoon caloric and lipid intake, and lower afternoon and night protein intake in prepubescents were associated with a better health profile, including improvements in cardiometabolic risk factors.

背景:时间营养可能影响儿童心脏代谢健康。了解这种关系可能对控制儿童肥胖至关重要。目的:探讨青春期前儿童时间营养与心脏代谢危险因素的关系。方法:本横断面研究纳入93名参与者(50名男性,5-12岁),分为健康体重(HW, n = 34)、超重(OV, n = 10)、肥胖(OB, n = 23)和严重肥胖(SOB, n = 26)。24小时饮食回顾评估了参与者的热量和能量底物摄入量,分析了早上(直到上午11点)、下午(上午11点至下午6点)、晚上(下午6点01分之后)和每天的总摄入量。通过空腹血糖、胰岛素血症、HOMA-IR、总胆固醇(TC)、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯(TG)、腹部脂肪(AF)和颈动脉内膜-中膜厚度(CIMT)的超声分析来评估心脏代谢风险。结论:青春期前儿童上午和下午碳水化合物摄入量增加,下午热量和脂质摄入量增加,下午和晚上蛋白质摄入量减少与较好的健康状况相关,包括心脏代谢危险因素的改善。
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引用次数: 0
Meal timing, nutritional status and diet quality in a group of Spanish children 一组西班牙儿童的进餐时间、营养状况和饮食质量。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-03-18 DOI: 10.1111/ijpo.70006
María Dolores Salas-González, Viviana Loria-Kohen, Aránzazu Aparicio, Laura M. Bermejo, Esther Cuadrado-Soto, Liliana Guadalupe González-Rodríguez, María del Carmen Lozano-Estevan, África Peral-Suárez, Adrián Cervera-Muñoz, Rosa M. Ortega, Ana M. López-Sobaler

Introduction

Some studies suggest that meal timing is involved in obesity and metabolic health. However, little is known about children, so the aim was to assess whether meal timing patterns affect nutritional status and diet quality in children.

Methods

A cross-sectional study was conducted on 880 children (8–13 years). Participants were classified according to the median timing of their first meal, last meal and the length of their eating window (12 h). Adjusted linear regression was used to evaluate associations between first meal timing, last meal timing or eating window and anthropometric, biochemical and dietary variables.

Results

A later last meal was associated with lower scores on the Healthy Eating Index (HEI-2020), Mediterranean Diet Score (MDS) and DASH diet [β (95% CI): −1.139 (−2.258; −0.021), −0.207 (−0.408; −0.007) and − 0.582 (−1.072; −0.092), respectively]. A longer eating window was associated with higher glucose levels, LDL-c, and the ratio LDL-c/HDL-c [β (95% CI): 3.204 (1.876; 4.532), 4.725 (1.109; 8.342), and 0.090 (0.014; 0.166), respectively].

Conclusion

Later meal timing and a prolonged eating window were linked to poorer diet quality and unfavourable metabolic markers. It may be relevant to consider meal timing as a preventive health strategy in the development of future dietary guidelines.

一些研究表明,进餐时间与肥胖和代谢健康有关。然而,对儿童知之甚少,所以目的是评估用餐时间模式是否会影响儿童的营养状况和饮食质量。方法:对880例8 ~ 13岁儿童进行横断面研究。参与者根据他们第一餐、最后一餐的中位数时间和进食窗口的长度(12小时)进行分类。采用调整后的线性回归来评估第一餐时间、最后一餐时间或进食窗口与人体测量、生化和饮食变量之间的关系。结果:最后一餐时间较晚与健康饮食指数(HEI-2020)、地中海饮食评分(MDS)和DASH饮食得分较低相关[β (95% CI): -1.139 (-2.258;-0.021), -0.207 (-0.408;-0.007)和- 0.582 (-1.072;-0.092),分别)。较长的进食窗口期与较高的葡萄糖水平、LDL-c和LDL-c/HDL-c比值相关[β (95% CI): 3.204 (1.876;4.532), 4.725 (1.109;8.342), 0.090 (0.014;0.166),分别)。结论:较晚的用餐时间和较长的进食时间与较差的饮食质量和不利的代谢指标有关。在制定未来的膳食指南时,考虑将进餐时间作为一种预防性健康策略可能是相关的。
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引用次数: 0
期刊
Pediatric Obesity
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