Pediatric Obesity最新文献_第2页

Liver Fat Is Associated With Elevated FGF21 in Youth With Obesity but Without MASLD 肝脏脂肪与肥胖但无MASLD的青年FGF21升高有关

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-10 DOI: 10.1111/ijpo.70092

Emir Tas, Eva C. Diaz, Xiawei Ou, Elisabet Børsheim, Silva Arslanian

Background

Youth with obesity are at risk for accumulating liver fat, even below the threshold for metabolic dysfunction-associated steatotic liver disease (MASLD), defined as ≥ 5% by MRI. While prior studies suggest that sub-threshold liver fat may carry metabolic risk, the role of fibroblast growth factor-21 (FGF21)—a liver-derived hormone responsive to metabolic stress—has not been well characterised in this context.

Objectives

To examine the association between liver fat < 5% and metabolic markers in pubertal youth with obesity, with a focus on FGF21.

Methods

This secondary cross-sectional analysis included 58 pubertal adolescents with obesity (62% female; mean age 14.7 ± 1.7 years) and liver fat < 5% by MRI-proton density fat fraction (PDFF). Fasting glucose, insulin, lipids, leptin, adiponectin and FGF21 were measured. Insulin sensitivity was estimated by homeostatic model assessment of insulin resistance (HOMA-IR). Associations between PDFF and metabolic markers were analysed using Spearman correlations and multivariable regression, adjusted for age, sex, race, ethnicity and body mass index standard deviation score (BMI SDS).

Results

The median PDFF was 2.68%. PDFF correlated positively with BMI SDS, waist circumference, glucose, triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) and FGF21. In adjusted models, PDFF remained independently associated with FGF21 (Beta = 52 pg/mL per 1% increase; p = 0.02), even after log transformation. No associations were observed with HOMA-IR, leptin, or adiponectin.

Conclusions

Among pubertal youth with obesity and liver fat below the MASLD threshold, modest increases in PDFF were independently associated with higher FGF21. These findings support the potential utility of FGF21 as a biomarker of early hepatic-metabolic stress in the framework of ‘pre-MASLD’ state—similar to pre-diabetes before the development of overt steatosis.

背景：肥胖青年有肝脏脂肪积累的风险，即使低于代谢功能障碍相关脂肪变性肝病（MASLD）的阈值，MRI定义为≥5%。虽然先前的研究表明，亚阈值肝脏脂肪可能携带代谢风险，但在这种情况下，成纤维细胞生长因子-21 （FGF21）的作用尚未得到很好的表征。FGF21是一种肝脏来源的激素，对代谢应激有反应。目的：探讨肝脏脂肪与肝脏脂肪之间的关系方法：这项二次横断面分析包括58名青春期肥胖青少年（62%为女性，平均年龄14.7±1.7岁）与肝脏脂肪之间的关系结果：中位PDFF为2.68%。PDFF与BMI SDS、腰围、葡萄糖、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）和FGF21呈正相关。在调整后的模型中，即使经过对数转换，PDFF仍然与FGF21独立相关（每增加1% β = 52 pg/mL; p = 0.02）。未观察到HOMA-IR、瘦素或脂联素的相关性。结论：在肥胖和肝脏脂肪低于MASLD阈值的青春期青少年中，PDFF的适度增加与FGF21的升高独立相关。这些发现支持FGF21作为“masld前期”框架下早期肝脏代谢应激的生物标志物的潜在效用，类似于发展为显性脂肪变性前的糖尿病前期。

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引用次数: 0

Endotoxin Markers Are Elevated in Adolescents With Obesity With and Without Metabolic Dysfunction-Associated Steatotic Liver Disease 青少年肥胖伴或不伴代谢功能障碍相关脂肪变性肝病的内毒素标志物升高

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-10 DOI: 10.1111/ijpo.70093

Alison M. Boone, Alyssa M. Bartlett, Jordan A. Bays, Youngsil Kim, Zhongxin Yu, Sirish K. Palle, Jacob E. Friedman, Kevin R. Short

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in paediatric patients. Adult and murine studies have suggested a role for endotoxin from gram-negative bacteria in the development of MASLD, but there is incomplete and conflicting evidence for its role in adolescents.

Purpose

To determine if adolescents with biopsy-proven MASLD have elevated endotoxin activity and whether endotoxin markers are associated with liver histological features.

Methods

Serum endotoxin core antibodies (EndoCab IgG), lipopolysaccharide binding protein (LBP), soluble CD14 (sCD14) and C-reactive protein (CRP) were measured in adolescents with obesity and MASLD (n = 46), and control groups without MASLD with obesity (Ob, n = 28) or normal weight (NW, n = 34).

Results

Compared to the NW group, both the MASLD and Ob groups had higher EndoCab IgG (56%), LBP (33%) and CRP (11-fold), while sCD14 did not differ. LBP and CRP were positively correlated to trunk and total body fat (r = 0.45 and 0.64, respectively), and to one another (r = 0.42), all p < 0.001. None of the endotoxin markers varied between boys and girls, or with liver steatosis grade or fibrosis stage within the MASLD group.

Conclusion

Serum markers of endotoxin activity and inflammation are increased in adolescents with obesity but are not further increased in patients with mild to moderate MASLD.

背景：代谢功能障碍相关脂肪变性肝病（MASLD）是儿科患者中最常见的慢性肝病。成人和小鼠研究表明，革兰氏阴性菌内毒素在MASLD的发展中起作用，但在青少年中其作用的证据不完整且相互矛盾。目的：确定活检证实的MASLD青少年是否有升高的内毒素活性，以及内毒素标志物是否与肝脏组织学特征相关。方法：测定肥胖合并MASLD的青少年（n = 46）、无MASLD的肥胖对照组（Ob, n = 28）和体重正常对照组（NW, n = 34）血清内毒素核心抗体（EndoCab IgG）、脂多糖结合蛋白（LBP）、可溶性CD14 （sCD14）和c反应蛋白（CRP）水平。结果：与NW组相比，MASLD和Ob组均有较高的EndoCab IgG (56%)， LBP（33%）和CRP（11倍），而sCD14无差异。LBP和CRP与躯干脂肪和全身脂肪呈显著正相关（r分别为0.45和0.64），两者之间呈显著正相关（r分别为0.42），均为p。结论：青少年肥胖患者血清内毒素活性和炎症指标升高，轻中度MASLD患者血清内毒素活性和炎症指标升高不明显。

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引用次数: 0

Effects of Semaglutide on BMI and Cardiometabolic Profile in Adolescents With Variants in Monogenic Obesity-Related Genes 西马鲁肽对单基因肥胖相关基因变异青少年BMI和心脏代谢谱的影响

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-10 DOI: 10.1111/ijpo.70091

Mostafa Salama, Doha Hassan, Filippo Pinto e Vairo, Aida Lteif, Roland Hentz, Ole Olson, Siobhan Pittock, Alaa Al Nofal, Ana Creo, Seema Kumar

Objectives

To evaluate the impact of semaglutide on body mass index (BMI) and cardiometabolic markers in adolescents with obesity and genetic variants associated with monogenic or syndromic obesity.

Methods

A retrospective chart review was conducted in adolescents with severe obesity who underwent multigene panel testing and were treated with semaglutide.

Results

Twenty-seven adolescents (mean age 15 ± 1.9 years); BMI % of the 95th percentile 158 ± 29; (70% White) were treated with semaglutide for a mean of 10 ± 4.7 months. Participants were classified into three groups: (1) Dominant or Known Risk Variants (n = 7); (2) Carriers of Rare Variants in Recessive Genes (n = 10); and (3) Negative or Unmatched Genetic Findings (n = 10). All groups showed reductions in BMI, which was not different between the groups. Adolescents with dominant or known risk variants experienced a significant decrease in BMI % of the 95th percentile (−17, (IQR −26 to −10) p = 0.022) and in BMI by −9.4% ± 7% (p = 0.035). Significant improvements in median non-HDL cholesterol (−16 mg/dL), total cholesterol (−15 mg/dL), and HbA1c (−0.3%) were noted in children with dominant or known risk variants (p = 0.036).

Conclusions

Semaglutide was associated with significant reductions in BMI and cardiometabolic markers in adolescents (majority White) with dominant or known risk variants for monogenic obesity.

目的：评估西马鲁肽对肥胖青少年体重指数（BMI）和心脏代谢指标的影响，以及与单基因或综合征型肥胖相关的遗传变异。方法：对接受多基因面板检测并接受西马鲁肽治疗的严重肥胖青少年进行回顾性图表回顾。结果：青少年27例（平均年龄15±1.9岁）；BMI第95百分位% 158±29；（70%为白种人）接受西马鲁肽治疗，平均10±4.7个月。参与者被分为三组：(1)显性或已知的风险变异（n = 7）；(2)隐性基因罕见变异携带者（n = 10）；(3)阴性或不匹配的遗传结果（n = 10）。所有组的体重指数都有所下降，各组之间没有差异。具有显性或已知风险变异的青少年的BMI在第95百分位的百分比显著下降（-17,(IQR -26至-10)p = 0.022）， BMI下降-9.4%±7% （p = 0.035）。在具有显性或已知危险变异的儿童中，非高密度脂蛋白胆固醇（-16 mg/dL）、总胆固醇（-15 mg/dL）和HbA1c（-0.3%）均有显著改善（p = 0.036）。结论：Semaglutide与单基因肥胖显性或已知危险变异的青少年（多数为白人）BMI和心脏代谢指标的显著降低相关。

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引用次数: 0

Unravelling the Ties: How Attachment Styles and Emotion Regulation Fuel Emotional Eating in Youth With Obesity—A Clinical Sample Study 解开联系：依恋类型和情绪调节如何推动肥胖青年的情绪性饮食-一项临床样本研究。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-09 DOI: 10.1111/ijpo.70095

Joana Gómez-Odriozola, Jolien Braet, Ine Verbiest, Caroline Braet

Emotional eating is critical in the development and maintenance of obesity among children and adolescents. While attachment's influence on emotional eating is increasingly recognised, little is known about how emotion regulation strategies mediate this, particularly in samples with obesity. This study examined how attachment dimensions affect emotional eating through different emotion regulation strategies in youths with obesity. 772 children and adolescents (ages 7–19) with obesity participated. Key variables were measured using validated questionnaires. Mediation effects were analysed through Structural Equation Modelling, with exploratory analyses assessing the role of the emotion regulation strategies diversity index and specific emotion regulation strategies. Higher attachment anxiety and avoidance were associated with greater emotional eating, both directly and indirectly through maladaptive emotion regulation strategies. Adaptive strategies did not show mediating effects. Attachment anxiety and avoidance increased the diversity of emotion regulation strategies, which was associated with higher emotional eating. Interventions may benefit from prioritising the effectiveness of these strategies and addressing maladaptive ones. Excessive diversity of emotion regulation strategies could reflect underlying difficulties and may be associated with higher emotional eating. A deeper understanding of the interplay between attachment and emotion regulation could inform more targeted approaches for preventing and treating obesity in youth.

情绪化进食对儿童和青少年肥胖的发展和维持至关重要。虽然人们越来越认识到依恋对情绪化进食的影响，但人们对情绪调节策略如何调节这种影响知之甚少，尤其是在肥胖样本中。本研究探讨依恋维度如何通过不同的情绪调节策略影响青少年肥胖患者的情绪化进食。772名肥胖儿童和青少年（7-19岁）参与了研究。使用有效问卷测量关键变量。通过结构方程模型分析中介效应，并通过探索性分析评估情绪调节策略多样性指数和特定情绪调节策略的作用。更高的依恋焦虑和回避与更大的情绪化进食有关，直接或间接地通过适应不良的情绪调节策略。适应性策略不存在中介效应。依恋焦虑和回避增加了情绪调节策略的多样性，这与高情绪进食有关。干预措施可能受益于优先考虑这些战略的有效性并解决适应不良的战略。情绪调节策略的过度多样性可能反映了潜在的困难，并可能与更高的情绪化进食有关。更深入地了解依恋和情绪调节之间的相互作用，可以为预防和治疗青少年肥胖提供更有针对性的方法。

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引用次数: 0

Household Food Insecurity Is Associated With Higher Adiposity Over Time Among Adolescents in Louisiana 随着时间的推移，路易斯安那州青少年的家庭食品不安全与较高的肥胖有关。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-05 DOI: 10.1111/ijpo.70084

Ashley Fenton, Amanda E. Staiano, Michael Celestin, Tekeda Ferguson, Candice A. Myers, Tung-Sung Tseng, Stephanie T. Broyles

Background

Few studies have examined how household food insecurity may impact longitudinal changes in adiposity among adolescents.

Objective

We investigated the link between household food insecurity and 2-year change in adolescent adiposity, with sex as a potential moderator.

Methods

Analyses included 222 adolescents living in and around Baton Rouge, Louisiana, who participated in the TIGER Kids study (baseline: June 2016–December 2017; follow-up: January 2018–August 2019). Household food security was measured using a validated two-question parent-reported survey. Adiposity outcomes were collected using anthropometry, dual-energy X-ray absorptiometry and abdominal magnetic resonance imaging (MRI). Multivariable multilevel models assessed associations between household food security and changes in adiposity.

Results

At baseline, the participants were 12.9 ± 1.9 years, 50.5% female, 37.4% non-White or Hispanic, 31.5% had obesity, and 11.3% were food insecure. Food-insecure adolescents exhibited significantly greater increases in BMI_p95 (b = 6.0% ± 2.2%, p = 0.0082), waist circumference (b = 4.1 ± 1.7 cm, p = 0.0158), total body fat percentage (b = 3.0% ± 1.3%, p = 0.0194) and visceral adipose tissue mass (b = 0.16 ± 0.06 kg, p = 0.0163), compared to their food-secure peers. The effect of food insecurity on adiposity did not differ between boys and girls.

Conclusions

This longitudinal study highlights the deleterious influence of food insecurity on adolescent adiposity. Efforts to alleviate food insecurity may play an important role in preventing obesity in adolescents.

背景：很少有研究调查家庭粮食不安全如何影响青少年肥胖的纵向变化。目的：我们调查了家庭食品不安全与青少年肥胖2年变化之间的联系，性别是一个潜在的调节因素。方法：分析了222名居住在路易斯安那州巴吞鲁日及其周边地区的青少年，他们参加了TIGER Kids研究（基线：2016年6月- 2017年12月；随访：2018年1月- 2019年8月）。家庭粮食安全是通过一个经过验证的由家长报告的两问题调查来衡量的。通过人体测量、双能x线吸收仪和腹部磁共振成像（MRI）收集肥胖结果。多变量多水平模型评估了家庭粮食安全与肥胖变化之间的关系。结果：基线时，参与者年龄为12.9±1.9岁，50.5%为女性，37.4%为非白人或西班牙裔，31.5%为肥胖，11.3%为食物不安全。食物不安全青少年的体重指数（BMIp95）（b = 6.0%±2.2%,p = 0.0082）、腰围（b = 4.1±1.7 cm, p = 0.0158）、体脂率（b = 3.0%±1.3%,p = 0.0194）和内脏脂肪组织质量（b = 0.16±0.06 kg, p = 0.0163）均显著高于食物安全青少年。食物不安全对肥胖的影响在男孩和女孩之间没有差异。结论：这项纵向研究强调了粮食不安全对青少年肥胖的有害影响。减轻粮食不安全的努力可能在预防青少年肥胖方面发挥重要作用。

{"title":"Household Food Insecurity Is Associated With Higher Adiposity Over Time Among Adolescents in Louisiana","authors":"Ashley Fenton, Amanda E. Staiano, Michael Celestin, Tekeda Ferguson, Candice A. Myers, Tung-Sung Tseng, Stephanie T. Broyles","doi":"10.1111/ijpo.70084","DOIUrl":"10.1111/ijpo.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Few studies have examined how household food insecurity may impact longitudinal changes in adiposity among adolescents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We investigated the link between household food insecurity and 2-year change in adolescent adiposity, with sex as a potential moderator.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Analyses included 222 adolescents living in and around Baton Rouge, Louisiana, who participated in the TIGER Kids study (baseline: June 2016–December 2017; follow-up: January 2018–August 2019). Household food security was measured using a validated two-question parent-reported survey. Adiposity outcomes were collected using anthropometry, dual-energy X-ray absorptiometry and abdominal magnetic resonance imaging (MRI). Multivariable multilevel models assessed associations between household food security and changes in adiposity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At baseline, the participants were 12.9 ± 1.9 years, 50.5% female, 37.4% non-White or Hispanic, 31.5% had obesity, and 11.3% were food insecure. Food-insecure adolescents exhibited significantly greater increases in BMI<sub>p95</sub> (<i>b</i> = 6.0% ± 2.2%, <i>p</i> = 0.0082), waist circumference (<i>b</i> = 4.1 ± 1.7 cm, <i>p</i> = 0.0158), total body fat percentage (b = 3.0% ± 1.3%, <i>p</i> = 0.0194) and visceral adipose tissue mass (<i>b</i> = 0.16 ± 0.06 kg, <i>p</i> = 0.0163), compared to their food-secure peers. The effect of food insecurity on adiposity did not differ between boys and girls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This longitudinal study highlights the deleterious influence of food insecurity on adolescent adiposity. Efforts to alleviate food insecurity may play an important role in preventing obesity in adolescents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residential Neighbourhood Environments and Health Behaviours Among Children and Adolescents Initiating Obesity Management Care: Secondary Analyses of Data From the CANadian Paediatric Weight Management Registry (CANPWR) 开始肥胖管理护理的儿童和青少年的居住社区环境和健康行为：加拿大儿科体重管理登记处（CANPWR）数据的二次分析

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-04 DOI: 10.1111/ijpo.70087

Yujia Tang, Sonia Semenic, Aurélie Baillot, Mylène Riva, Geoff D. C. Ball, Stasia Hadjiyannakis, Jill Hamilton, Josephine Ho, Laurent Legault, Ian Zenlea, Katherine M. Morrison, Andraea Van Hulst

Objective

Examine associations between neighbourhood characteristics and health behaviours (physical activity, screen time, sleep duration) in boys and girls initiating obesity management care across Canada.

Methods

We analysed cross-sectional data from the CANadian Paediatric Weight management Registry (2013–2017) for 803 participants (with overweight or obesity; 5–17 years old). Questionnaire-assessed health behaviours included total physical activity (PA), organised PA outside of school, screen time, and sleep duration. Total PA was classified as high vs. low based on current recommendations, organised PA as high vs. low based on average attained levels for Canadian children, and screen time and sleep duration as meeting vs. not meeting recommendations. Neighbourhood characteristics (walkability, greenness, material and social deprivation) were computed for the first three digits of residential postal codes. Covariate-adjusted associations were examined using generalised estimating equations stratified by sex.

Results

Participants (50% boys; mean ± SD: age, 11.9 ± 3.1 years; BMI z-score, 3.28 ± 1.06) living in low (vs. high) social deprivation neighbourhoods were more likely to engage in high total PA, particularly among boys (PR = 1.32, 95% CI: 1.01, 1.73). Boys living in neighbourhoods with high (vs. low) walkability (PR = 3.56, 95% CI: 1.97, 6.44) and higher greenness (PR = 1.72, 95% CI: 1.17, 2.64) were more likely to engage in high organised PA. Girls living in neighbourhoods with very low (vs. high) material deprivation were more likely to engage in high organised PA (PR = 4.17, 95% CI: 1.52, 11.45). No associations were found for screen time or sleep duration.

Conclusions

This study adds to the evidence linking neighbourhood environments to health behaviours in children and adolescents living with obesity and who are initiating obesity management care. Specifically, less social deprivation and greater walkability and greenness were associated with higher PA among boys, while less material deprivation was linked to higher PA among girls.

目的：研究加拿大各地发起肥胖管理护理的男孩和女孩的邻里特征与健康行为（身体活动、屏幕时间、睡眠时间）之间的关系。方法：我们分析了来自加拿大儿科体重管理登记处（2013-2017）的803名参与者（超重或肥胖；5-17岁）的横断面数据。问卷评估的健康行为包括总体力活动（PA）、校外有组织的PA、屏幕时间和睡眠时间。总PA根据目前的建议分为高与低，有组织PA根据加拿大儿童的平均达到水平分为高与低，屏幕时间和睡眠时间为符合与不符合建议。根据居民邮政编码的前三位数字计算了社区特征（可步行性、绿色、物质和社会剥夺）。用按性别分层的广义估计方程检验协变量调整的关联。结果：生活在低（高）社会剥夺社区的参与者（50%为男孩；平均±SD：年龄，11.9±3.1岁；BMI z-score, 3.28±1.06）更有可能从事高总PA，尤其是男孩（PR = 1.32, 95% CI: 1.01, 1.73）。生活在可步行性高（相对于低）社区（PR = 3.56, 95% CI: 1.97, 6.44）和绿色度高（PR = 1.72, 95% CI: 1.17, 2.64）的男孩更有可能参与高组织的PA。生活在物质匮乏程度非常低（相对较高）社区的女孩更有可能参与高度组织化的PA （PR = 4.17, 95% CI: 1.52, 11.45）。屏幕时间和睡眠时间没有关联。结论：本研究为社区环境与肥胖儿童和青少年健康行为之间的联系提供了新的证据，这些儿童和青少年正在接受肥胖管理护理。具体来说，较少的社会剥夺和更大的步行性和绿化与男孩的高PA相关，而较少的物质剥夺与女孩的高PA相关。

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引用次数: 0

Associations of Maternal Prenatal Inflammation With Child Adiposity: The Healthy Start Study 母亲产前炎症与儿童肥胖的关系：健康开始研究。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-02-01 DOI: 10.1111/ijpo.70088

Makayla Moran, Kyle Salmon, Satvinder K. Dhaliwal, Dana Dabelea, Wei Perng

Introduction

While inflammation is a normal physiological process of pregnancy, exposure to excess inflammation in utero may have unfavourable consequences for the offspring's health. This analysis investigated associations of prenatal inflammation with offspring adiposity in early childhood.

Methods

Among 555 mother–offspring pairs in the Healthy Start Study, we measured three inflammation biomarkers—C-reactive protein, interleukin-6 and tumour necrosis factor-α—at ~28 gestational weeks. We internally standardised each biomarker and took its average as an indicator of overall exposure to prenatal inflammation. When offspring were 4–6 years old, we measured weight and height for body mass index (BMI) z-score calculation; waist circumference; and % fat mass (%FM) using air displacement plethysmography. In the analysis, we used linear regression to examine associations of the prenatal inflammation z-score with offspring outcomes. As an exploratory analysis, we conducted stratified analysis by maternal race/ethnicity, which is known to modify associations in maternal–child health studies.

Results

After adjusting for offspring age and sex, each increment in the prenatal inflammation z-score corresponded with 0.31 (95% CI: 0.14, 0.48) higher BMI z-score, 1.43 (0.61, 2.25) cm higher waist circumference and 1.47 (0.43, 2.51) higher %FM in offspring. Further adjustment for maternal pre-pregnancy BMI attenuated estimates to the null for BMI z-score and waist circumference, but less for %FM (0.77 [−0.39, 1.94]; p = 0.19). These associations were driven by Hispanic mother–offspring pairs.

Conclusions

Prenatal inflammation may predispose offspring to greater adiposity during early childhood. This association is partially explained by maternal BMI and driven by participants of Hispanic ethnicity.

Trial Registration

NCT #002273297

虽然炎症是妊娠的正常生理过程，但在子宫内暴露于过度炎症可能对后代的健康产生不利后果。这项分析调查了产前炎症与儿童早期后代肥胖的关系。方法：在555对健康开始研究的母-子代中，我们在妊娠~28周测量了3种炎症生物标志物- c反应蛋白、白细胞介素-6和肿瘤坏死因子-α。我们对每个生物标志物进行了内部标准化，并将其平均值作为总体暴露于产前炎症的指标。当子代4-6岁时，测量体重和身高，计算体重指数（BMI） z分数；腰围;和%脂肪量（%FM）使用空气置换体积脉搏图。在分析中，我们使用线性回归来检验产前炎症z评分与后代结局的关系。作为一项探索性分析，我们根据母亲的种族/民族进行了分层分析，这在母婴健康研究中是已知的。结果：在调整后代年龄和性别后，产前炎症z-score每增加一次，后代BMI z-score增加0.31 (95% CI: 0.14, 0.48)，腰围增加1.43 (0.61,2.25)cm， FM %增加1.47（0.43,2.51）。进一步调整孕妇孕前BMI使BMI z-score和腰围的估计值降至零值，但对%FM的估计值较低（0.77 [-0.39,1.94];p = 0.19）。这些关联是由西班牙裔母亲和子女配对驱动的。结论：产前炎症可能使后代在儿童早期更容易肥胖。这种关联部分是由母亲的BMI解释的，并受到西班牙裔参与者的推动。试验注册：NCT #002273297。

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引用次数: 0

Early Determinants of Overweight and Obesity in Children Aged Under 2 Years in Mexico 墨西哥2岁以下儿童超重和肥胖的早期决定因素

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-01-21 DOI: 10.1111/ijpo.70085

Lucía Hernández-Barrera, Belem Trejo-Valdivia, Danilo Castro-Sifuentes, Velia Margarita Cárdenas-Villarreal

Introduction

Obesity in infants is a growing problem in Mexico, affecting children's well-being and increasing long-term health risks. Evidence of the multilevel determinants during the first 1000 days is limited. This study aimed to examine the relationship between individual, maternal, household and the prevalence of overweight and obesity in children under 2 years of age.

Methods

A secondary analysis of the 2021 National Health and Nutrition Survey was conducted with a sample of 185 mother-infant binomials. To assess the combined prevalence of overweight and obesity (ow_ob) in infants, body mass index Z-scores were calculated by age and sex. By age group, multiple logistic regression models were adjusted to evaluate the association between childhood ow_ob and individual, maternal, household and place of residence variables.

Results

A combined prevalence of overweight and obesity of 29.7% was found. In infants aged 0–11 months, the highest probability of ow_ob (pr_ob = 0.87) was amongst infants of overweight mothers who worked outside the home. In infants aged 12–23 months, the highest likelihood of ow_ob (pr_ob = 0.885) was for children whose mothers had lower levels of education, were married, had a diagnosis of depression and experienced moderate or severe food insecurity.

Conclusions

This study is one of the first in Mexico to analyse multiple risk factors simultaneously at the national level, as it had a representative sample of children under 2 years old. The findings underscore the importance of early intervention and a comprehensive approach considering family and socioeconomic factors in childhood obesity prevention.

在墨西哥，婴儿肥胖是一个日益严重的问题，影响儿童的健康并增加长期健康风险。在前1000天内，多层次决定因素的证据有限。本研究旨在探讨个人、母亲、家庭与2岁以下儿童超重和肥胖患病率之间的关系。方法：对2021年全国健康与营养调查进行二次分析，样本为185名母婴。为了评估婴儿超重和肥胖（ow_ob）的联合患病率，体重指数z分数按年龄和性别计算。按年龄组调整多元logistic回归模型，评估儿童ow_ob与个体、母亲、家庭和居住地变量的相关性。结果：超重和肥胖的总患病率为29.7%。在0-11个月大的婴儿中，超重母亲外出工作的婴儿患ow_ob的概率最高（pr_ob = 0.87）。在12-23个月大的婴儿中，母亲受教育程度较低、已婚、被诊断为抑郁症、经历中度或重度食品不安全的儿童患ow_ob的可能性最高（pr_ob = 0.885）。结论：这项研究是墨西哥第一个在国家层面同时分析多种风险因素的研究之一，因为它有2岁以下儿童的代表性样本。研究结果强调了早期干预和综合考虑家庭和社会经济因素在儿童肥胖预防中的重要性。

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引用次数: 0

Socioeconomic Vulnerability and Its Associations With Dietary Patterns and Obesity Degree Among Children in Families Across Six European Countries: The Feel4Diabetes-Study 6个欧洲国家家庭儿童的社会经济脆弱性及其与饮食模式和肥胖程度的关系：感觉糖尿病研究

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-01-20 DOI: 10.1111/ijpo.70072

Lubna Mahmood, Luis A. Moreno, Peter Schwarz, Lieven Annemans, Greet Cardon, Soukaina Hilal, Imre Rurik, Violeta Iotova, Natalya Usheva, Tsvetalina Tankova, Costas Anastasiou, Yannis Manios, Esther M. Gonzalez-Gil, the Feel4Diabetes-Study Group

Introduction

Previous studies suggest that children from lower socioeconomic status may be at higher risk of unhealthy eating. This study aims to examine the cumulative socioeconomic vulnerabilities and their association with dietary patterns and obesity levels in European children.

Methods

A total of 9664 parent-child dyads (79% mothers; 50.8% girls) from six European countries participated in the study. Families provided baseline information on energy balance-related behaviours and socioeconomic factors through questionnaires. Children's dietary habits were evaluated using semi-quantitative food frequency questionnaires, and anthropometric data were collected. Vulnerabilities were quantified through a composition of variables based on household income, parental education and employment. Multivariable and logistic regression analyses were performed.

Results

The study found significant associations between socioeconomic vulnerability and children's dietary habits and body mass index. Higher vulnerability was linked to a lower probability of fruit and vegetable intake, and a higher probability of consuming red meat, and energy-dense snacks. Children with the highest vulnerability had nearly four times higher odds of overweight/obesity (OR = 3.82, 95% CI: 3.05–4.76).

Conclusions

The findings of this study indicate that European children from families with a high socioeconomic vulnerability tend to have an unhealthy dietary profile and a higher degree of obesity. Therefore, public health programs should prioritise families facing high socioeconomic vulnerabilities promoting healthy eating to prevent childhood obesity at early stages.

Trial Registration

Clinical trials registry http://clinicaltrials.gov: NCT02393872

先前的研究表明，社会经济地位较低的儿童可能有更高的不健康饮食风险。本研究旨在研究欧洲儿童的累积社会经济脆弱性及其与饮食模式和肥胖水平的关系。方法：来自欧洲6个国家共9664对亲子对（79%为母亲，50.8%为女孩）参与研究。家庭通过问卷提供了与能量平衡相关的行为和社会经济因素的基线信息。采用半定量食物频率问卷对儿童的饮食习惯进行评估，并收集人体测量数据。脆弱性通过基于家庭收入、父母教育和就业的变量组合来量化。进行了多变量和逻辑回归分析。结果：研究发现社会经济脆弱性与儿童饮食习惯和体重指数之间存在显著关联。较高的脆弱性与摄入水果和蔬菜的可能性较低，以及食用红肉和高能量零食的可能性较高有关。最脆弱的儿童超重/肥胖的几率几乎是其他儿童的四倍（OR = 3.82, 95% CI: 3.05-4.76）。结论：本研究的结果表明，来自高社会经济脆弱性家庭的欧洲儿童往往有不健康的饮食习惯和更高程度的肥胖。因此，公共卫生计划应优先考虑面临高社会经济脆弱性的家庭，促进健康饮食，以预防儿童早期肥胖。临床试验注册：http://clinicaltrials.gov: NCT02393872。

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引用次数: 0

Correction to ‘30-Day Morbidity and Mortality of Bariatric Metabolic Surgery in Adolescence During the COVID-19 Pandemic—The GENEVA Study’ 对“2019冠状病毒病大流行期间青少年减肥代谢手术30天发病率和死亡率——日内瓦研究”的更正。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity

Pub Date : 2026-01-15 DOI: 10.1111/ijpo.70086

R. Singhal, T. Wiggins, J. Super, et al., “30-Day Morbidity and Mortality of Bariatric Metabolic Surgery in Adolescence During the COVID-19 Pandemic—The GENEVA Study,” Pediatric Obesity 16, no. 12 (2021): e12832. https://doi.org/10.1111/ijpo.12832.

The first name of one of the collaborative authors was mistakenly misspelled. The correct full name of the author is ‘Ahmet Bozdag’.

We apologise for this error.

R. Singhal， T. Wiggins， J. Super，等，“2019冠状病毒病大流行期间青少年减肥代谢手术的30天发病率和死亡率-日内瓦研究”，《儿童肥胖》，第16期。12 (2021): e12832。https://doi.org/10.1111/ijpo.12832.The其中一位合作作者的名字被拼错了。作者的正确全名是“Ahmet Bozdag”。我们为这个错误道歉。

引用次数: 0