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Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping 青少年行为干预与饮食失调结果的组成部分:干预制图的系统回顾
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70074
Natalie B. Lister, Rabia Khalid, Isabelle R. Jardine, Samantha Pryde, Hannah Melville, Anna L. Seidler, Kylie E. Hunter, Amy L. Ahern, Louise A. Baur, Caroline Braet, Sarah P. Garnett, Andrew J. Hill, Sarah Maguire, Dasha Nicholls, Susan J. Paxton, Milan K. Piya, Amanda Sainsbury, Katharine Steinbeck, Denise E. Wilfley, Kelly Cooper, Genevieve Dammery, Alicia M. Grunseit, Faith Anne N. Heeren, Rebecca A. Jones, Theodore K. Kyle, Fiona Quigley, Molly Robbins, Jacqlyn Yourell, Melanie K. Bean, Maxine P. Bonham, Kerri N. Boutelle, Michelle I. Cardel, Katherine E. Darling, Aimee L. Dordevic, Dawn M. Eichen, Leonard H. Epstein, Andrea B. Goldschmidt, Elissa Jelalian, Mara Cristina Lofrano-Prado, Tiffany Naets, Wagner L. Prado, Hanna F. Skjåkødegård, Yngvild Sørebø Danielsen, Richard I. Stein, Marian Tanofsky-Kraff, Annelies Van Eyck, Alaina P. Vidmar, Jack A. Yanovski, Brittany J. Johnson, Hiba Jebeile, the EDIT Collaboration

Objective

To understand delivery features and intervention strategies of adolescent weight management interventions which may influence eating disorder risk.

Methods

Systematic searches in four databases and two trial registries to identify randomised controlled trials in adolescents with overweight/obesity measuring eating disorder risk pre- and post-intervention. Delivery features and intervention strategies were coded from published descriptions using a project-specific codebook, validated by trial investigators and narratively synthesised.

Results

Of 11 860 records screened, 23 trials, with 54 intervention arms, were included in the analysis. Most interventions focused on weight loss and maintenance (54%) and were informed by a cognitive behavioural framework (43%). Interventions commonly targeted an individual with a support person (70%). Median intervention duration was 26 weeks, with weekly (35%) or staged (e.g., weekly, then monthly) visit (41%) frequency. Interventions had a mean (SD) of 30 (16.1) intervention strategies. Most included healthy eating education (89%), physical activity education (89%) and problem-solving barriers to dietary change (80%). Few included mental health strategies (17%). Interventions included ‘dietary prescription’ (65%), and 78% promoted ‘healthful/helpful eating behaviours’.

Conclusion

Weight management interventions are complex and vary in delivery approach and strategies used to change behaviors. Characterising interventions is a critical first step to understanding how weight management interventions' influence eating disorder risk.

目的了解影响青少年饮食失调风险的体重管理干预措施的实施特点及干预策略。方法系统检索4个数据库和2个试验注册中心,确定超重/肥胖青少年干预前后测量饮食失调风险的随机对照试验。交付特征和干预策略使用项目特定代码本从发表的描述中编码,由试验调查员验证并叙述合成。结果在筛选的11,860份记录中,有23项试验,54个干预组被纳入分析。大多数干预措施侧重于减肥和维持体重(54%),并通过认知行为框架(43%)提供信息。干预措施通常针对有支持人员的个人(70%)。中位干预持续时间为26周,每周(35%)或分阶段(例如,每周,然后每月)访问频率(41%)。干预措施的平均(SD)为30(16.1)个干预策略。大多数包括健康饮食教育(89%)、体育活动教育(89%)和解决饮食改变障碍(80%)。很少包括心理健康战略(17%)。干预措施包括“饮食处方”(65%),78%的干预措施促进“健康/有益的饮食行为”。结论体重管理干预是复杂的,在实施方式和改变行为的策略上存在差异。描述干预措施是理解体重管理干预措施如何影响饮食失调风险的关键第一步。
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引用次数: 0
Beyond Gestational Diabetes: Maternal and Offspring Health and Lifestyle 3 Years Postnatally in a Secondary Analysis of the UPBEAT Trial Cohort 妊娠期糖尿病后:母亲和后代的健康和出生后3年的生活方式在乐观试验队列的二次分析
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70076
Claire Singleton, Danqi Zhuang, Kimberley Kavanagh, Kathyrn V. Dalrymple, Angela C. Flynn, Lucilla Poston, Claire L. Meek, Sara L. White

Background

Gestational diabetes (GDM) is associated with increased future obesity risk in affected mothers and children.

Objective

We assessed if dietary behaviours learnt during a GDM pregnancy positively impact maternal and child health 3 years postpartum.

Method

In a secondary analysis, we included women with obesity recruited to the UPBEAT randomised controlled trial with 3-year follow-up postnatally (n = 441). Maternal and offspring anthropometry and dietary data were recorded antenatally and at follow-up. Data were assessed using linear/logistic regression, adjusting for confounders.

Results

Women with GDM (22%) had higher BMI (median 35.6 vs. 34.2 kg/m2; p = 0.049) and energy intake (1738.2 vs. 1551.6 kcal/day; p = 0.005) at ~16 weeks' gestation compared to unaffected women, but lower gestational weight gain (4.5 kg vs. 6.6 kg; p < 0.001). However, at 3 years postpartum BMI was similar between groups (35.8 vs. 35.2 kg/m2; p > 0.5). GDM-exposed infants had a higher birthweight (55.4 vs. 45.9th centile; p = 0.008) than unexposed infants and at 3 years of age were more likely to be overweight/obese (International Obesity Task Force, IOTF, standards; OR 2.32; 95% CI 1.38, 3.91) but with similar skinfold thicknesses and dietary patterns.

Conclusion

Women with GDM demonstrated reduced gestational weight gain, and despite a higher BMI than women without GDM in early pregnancy, this difference was not evident at 3 years postpartum. However, while maternal and offspring dietary behaviours were comparable between groups, exposed offspring were at increased risk of overweight/obesity at 3 years of age.

妊娠期糖尿病(GDM)与受影响的母亲和儿童未来肥胖风险增加有关。目的评估妊娠期GDM患者饮食行为对产后3年母婴健康的积极影响。方法在二次分析中,我们将肥胖妇女纳入了乐观随机对照试验,产后随访3年(n = 441)。在产前和随访时记录母体和后代的人体测量和饮食数据。使用线性/逻辑回归评估数据,调整混杂因素。结果:妊娠16周时,GDM患者(22%)的BMI(中位数35.6 vs 34.2 kg/m2, p = 0.049)和能量摄入(1738.2 vs 1551.6 kcal/day, p = 0.005)高于未受影响的女性,但妊娠体重增加较低(4.5 kg vs 6.6 kg, p < 0.001)。然而,在产后3年,两组之间的BMI相似(35.8 vs. 35.2 kg/m2; p > 0.5)。gdm暴露的婴儿比未暴露的婴儿出生体重更高(55.4比45.9,p = 0.008),并且在3岁时更容易超重/肥胖(国际肥胖工作组,IOTF,标准;OR 2.32; 95% CI 1.38, 3.91),但皮肤折叠厚度和饮食模式相似。结论GDM妇女妊娠期体重增加减少,尽管妊娠早期BMI高于非GDM妇女,但产后3年差异不明显。然而,虽然两组之间的母亲和后代的饮食行为是相似的,但暴露的后代在3岁时超重/肥胖的风险增加。
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引用次数: 0
Inflammatory Dietary Pattern Associated With Metabolic Biomarkers, Blood Pressure and Anthropometric Indicators in Brazilian Adolescents 炎症性饮食模式与巴西青少年代谢生物标志物、血压和人体测量指标相关
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70079
Luana S. Blaudt, Taís de S. Lopes, Amanda de M. Souza, Geisa Gabriela B. Rodrigues, Iuna A. Alves, Rosangela A. Pereira

Background

Diet may influence the subclinical inflammatory responses related to metabolic disorders.

Objective

To identify a dietary pattern associated with inflammatory biomarkers and to evaluate its association with metabolic, clinical and anthropometric indicators in Brazilian adolescents.

Methods

Data from Brazilian adolescents aged 12–17 years participating in the Study of Cardiovascular Risk in Adolescents (ERICA, 2013–2014) were analysed. Dietary intake was assessed using a 24-h dietary recall. A dietary pattern was derived using the Partial Least Squares regression in a subset (n = 3703) with C-reactive protein and adiponectin as intermediate variables and retaining food groups with factor loadings ≥ |0.15|. Associations between the pro-inflammatory dietary pattern and anthropometric indicators and metabolic biomarkers were examined in a subsample of adolescents (n = 36 956) using crude and adjusted multiple linear regression models.

Results

The pro-inflammatory dietary pattern was characterised by positive loadings for soft drinks, cakes, cheese, fats, pasta, snacks, sweets and bread, and with negative loadings for rice, milk-based dishes, poultry, fish and beans. The mean inflammatory dietary pattern score was 0.05 overall, and higher for girls (0.08) than boys (0.03). Significant associations (p < 0.05) were found between the pro-inflammatory dietary pattern and increased BMI (β = 0.07 kg/m2), fasting blood glucose (β = 0.20 mg/dL) and HOMA-IR (β = 0.03), after adjusting for sex, age, school type, diet report quality and daily energy intake.

Conclusions

Among Brazilian adolescents, a pro-inflammatory dietary pattern was associated with higher body weight, fasting glucose and insulin resistance.

饮食可能影响与代谢紊乱相关的亚临床炎症反应。目的确定与炎症生物标志物相关的饮食模式,并评估其与巴西青少年代谢、临床和人体测量指标的关系。方法对参与青少年心血管风险研究(ERICA, 2013-2014)的12-17岁巴西青少年的数据进行分析。采用24小时饮食回忆法评估膳食摄入量。以c反应蛋白和脂联素为中间变量,保留因子负荷≥| - 0.15|的食物组,采用偏最小二乘回归法对一个子集(n = 3703)进行饮食模式推导。在青少年亚样本(n = 36956)中,使用粗糙和调整后的多元线性回归模型检验了促炎饮食模式与人体测量指标和代谢生物标志物之间的关系。结果:促炎饮食模式的特点是软饮料、蛋糕、奶酪、脂肪、面食、零食、糖果和面包的积极负荷,而大米、牛奶类菜肴、家禽、鱼和豆类的消极负荷。炎性饮食模式平均评分为0.05,女孩(0.08)高于男孩(0.03)。在调整性别、年龄、学校类型、饮食报告质量和每日能量摄入后,促炎饮食模式与BMI (β = 0.07 kg/m2)、空腹血糖(β = 0.20 mg/dL)和HOMA-IR (β = 0.03)升高存在显著相关(p < 0.05)。结论:在巴西青少年中,促炎饮食模式与较高的体重、空腹血糖和胰岛素抵抗有关。
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引用次数: 0
The Appetitive Responses to a Meal Are Not Affected by Its Carbohydrate Content in Adolescents With Obesity: A Pilot Study 肥胖青少年对一餐的食欲反应不受其碳水化合物含量的影响:一项初步研究。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70077
Ghamdi Zainab, Moore Halim, Siroux Julie, Beraud Duane, Shaea Alkahtani, Abdullah F. Alghannam, Pereira Bruno, Masurier Julie, Finlayson Graham, Julian Valérie, Isacco Laurie, Thivel David

Background

Low-carbohydrate (CHO) or ketogenic diets have been proposed as alternative interventions to caloric restriction to address the childhood obesity epidemic. However, empirical support for this dietary strategy has remained inconclusive in youth. The objective was to test the hypothesis that consumption of a meal lower in the proportion of CHO relative to fat acutely elicits greater satiety, and lower preference for sweet and high-fat foods and energy intake at the subsequent meal in adolescents with obesity.

Methods

In a randomised crossover trial, 15 adolescents with obesity (7 females; 13.2 ± 1.8 years) consumed 3 isocaloric lunch meals on 3 different occasions: (i) moderate (52%), (ii) low (24%) or (iii) very low (7%) in CHO with commensurately adjusted fat content and matched for protein. Adolescents rated their appetite sensations at regular intervals throughout each test day (visual analogue scales). Food reward was recorded before and after the lunch meal, and prior to an ad libitum dinner (French version of the Leeds Food Preference Questionnaire [LFPQ-fr]), from which energy and macronutrient intake was quantified.

Results

No significant differences in energy or macronutrient intake at dinner or daily appetite sensations were found between conditions. Similarly, the proportions of CHO and fat had no effect on liking or wanting for high-fat or sweet foods. Rather, choice frequency for sweet foods appeared to increase after consumption of each meal (p = 0.048).

Conclusion

In the context of isocaloric meals, lowering the CHO content with a commensurate increase in fat, does not significantly alter satiety, food reward or subsequent energy intake during a test meal in adolescents with obesity.

背景:低碳水化合物(CHO)或生酮饮食已被提出作为热量限制的替代干预措施,以解决儿童肥胖的流行。然而,这种饮食策略的经验支持在年轻人中仍然没有定论。研究的目的是验证这样一种假设,即在肥胖的青少年中,CHO相对于脂肪的比例较低的一餐会强烈地引起更大的饱腹感,并降低对甜食和高脂肪食物的偏好和随后一餐的能量摄入。方法:在一项随机交叉试验中,15名肥胖青少年(7名女性,13.2±1.8岁)在3种不同的场合食用3顿等热量午餐:(i)中等(52%),(ii)低(24%)或(iii)非常低(7%)的CHO,相应调整脂肪含量并匹配蛋白质。青少年在每个测试日定期评估他们的食欲感觉(视觉模拟量表)。在午餐前后和随意晚餐之前记录食物奖励(法国版利兹食物偏好问卷[LFPQ-fr]),从中量化能量和大量营养素的摄入。结果:在两种情况下,晚餐时的能量或常量营养素摄入量或日常食欲感觉没有显着差异。同样,CHO和脂肪的比例对喜欢或不喜欢高脂肪或甜食没有影响。相反,每顿饭吃完后,选择甜食的频率似乎增加了(p = 0.048)。结论:在等热量膳食的情况下,降低CHO含量并相应增加脂肪,不会显著改变肥胖青少年在测试餐期间的饱腹感、食物奖励或随后的能量摄入。
{"title":"The Appetitive Responses to a Meal Are Not Affected by Its Carbohydrate Content in Adolescents With Obesity: A Pilot Study","authors":"Ghamdi Zainab,&nbsp;Moore Halim,&nbsp;Siroux Julie,&nbsp;Beraud Duane,&nbsp;Shaea Alkahtani,&nbsp;Abdullah F. Alghannam,&nbsp;Pereira Bruno,&nbsp;Masurier Julie,&nbsp;Finlayson Graham,&nbsp;Julian Valérie,&nbsp;Isacco Laurie,&nbsp;Thivel David","doi":"10.1111/ijpo.70077","DOIUrl":"10.1111/ijpo.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Low-carbohydrate (CHO) or ketogenic diets have been proposed as alternative interventions to caloric restriction to address the childhood obesity epidemic. However, empirical support for this dietary strategy has remained inconclusive in youth. The objective was to test the hypothesis that consumption of a meal lower in the proportion of CHO relative to fat acutely elicits greater satiety, and lower preference for sweet and high-fat foods and energy intake at the subsequent meal in adolescents with obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a randomised crossover trial, 15 adolescents with obesity (7 females; 13.2 ± 1.8 years) consumed 3 isocaloric lunch meals on 3 different occasions: (i) moderate (52%), (ii) low (24%) or (iii) very low (7%) in CHO with commensurately adjusted fat content and matched for protein. Adolescents rated their appetite sensations at regular intervals throughout each test day (visual analogue scales). Food reward was recorded before and after the lunch meal, and prior to an ad libitum dinner (French version of the Leeds Food Preference Questionnaire [LFPQ-fr]), from which energy and macronutrient intake was quantified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences in energy or macronutrient intake at dinner or daily appetite sensations were found between conditions. Similarly, the proportions of CHO and fat had no effect on liking or wanting for high-fat or sweet foods. Rather, choice frequency for sweet foods appeared to increase after consumption of each meal (<i>p</i> = 0.048).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the context of isocaloric meals, lowering the CHO content with a commensurate increase in fat, does not significantly alter satiety, food reward or subsequent energy intake during a test meal in adolescents with obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BMI Percentile Cutoffs for Overweight and Obesity Are Set Too High in Terms of Adiposity and Metabolic Markers for Asian Children and Adolescents 就亚洲儿童和青少年的肥胖和代谢指标而言,超重和肥胖的BMI百分位数临界值设定得过高
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70075
Suk-Jin Hong, Xinlian Zhang, Phillipp Hartmann

Objectives

Asian adults develop metabolic complications at lower body mass indices (BMIs) compared with other ethnic groups, leading to lower BMI cutoffs for overweight and obesity. However, it remains unclear whether such adjustments are warranted in Asian children and adolescents. We aimed to determine whether lower BMI percentile cutoffs should be considered for overweight and obesity among Asian children and adolescents in the United States.

Methods

We analysed nationally representative data from U.S. children and adolescents from NHANES, 2012–2020. Metabolic parameters—including truncal fat percentage, glycemic markers, lipid profiles and liver disease markers—were compared between Asian and non-Asian participants within the 85–95th percentile and ≥ 95th percentile ranges. Metabolic parameter-based matching analyses identified corresponding BMI percentiles between groups.

Results

Asian children had more pronounced metabolic abnormalities than non-Asians in the overweight and obesity groups. After matching for metabolic parameters, Asians had the same levels of metabolic dysfunction at lower BMI percentiles than non-Asians, with averaged differences of approximately 3–9 BMI percentiles across various BMI percentile ranges.

Conclusions

Asian children and adolescents experience elevated metabolic risks at currently defined BMI percentiles. Lower BMI cutoffs targeting the 80th percentile for overweight and 90th percentile for obesity may improve early detection of metabolic risks in the Asian paediatric population.

与其他种族相比,亚洲成年人在较低的身体质量指数(BMI)下发生代谢并发症,导致超重和肥胖的BMI临界值较低。然而,目前尚不清楚这种调整是否适用于亚洲儿童和青少年。我们的目的是确定在美国的亚洲儿童和青少年中是否应该考虑较低的BMI百分位数临界值来治疗超重和肥胖。方法分析2012-2020年NHANES中具有全国代表性的美国儿童和青少年数据。在85 - 95百分位和≥95百分位范围内比较亚洲和非亚洲参与者的代谢参数,包括躯干脂肪百分比、血糖标志物、脂质谱和肝脏疾病标志物。基于代谢参数的匹配分析确定了组间相应的BMI百分位数。结果在超重和肥胖组中,亚洲儿童比非亚洲儿童有更明显的代谢异常。在对代谢参数进行匹配后,亚洲人在较低BMI百分位数与非亚洲人的代谢功能障碍水平相同,在不同BMI百分位数范围内的平均差异约为3-9个BMI百分位数。结论:根据目前定义的BMI百分位数,亚洲儿童和青少年的代谢风险较高。较低的BMI临界值,针对超重的第80百分位和肥胖的第90百分位,可以改善亚洲儿科人群代谢风险的早期检测。
{"title":"BMI Percentile Cutoffs for Overweight and Obesity Are Set Too High in Terms of Adiposity and Metabolic Markers for Asian Children and Adolescents","authors":"Suk-Jin Hong,&nbsp;Xinlian Zhang,&nbsp;Phillipp Hartmann","doi":"10.1111/ijpo.70075","DOIUrl":"https://doi.org/10.1111/ijpo.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Asian adults develop metabolic complications at lower body mass indices (BMIs) compared with other ethnic groups, leading to lower BMI cutoffs for overweight and obesity. However, it remains unclear whether such adjustments are warranted in Asian children and adolescents. We aimed to determine whether lower BMI percentile cutoffs should be considered for overweight and obesity among Asian children and adolescents in the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analysed nationally representative data from U.S. children and adolescents from NHANES, 2012–2020. Metabolic parameters—including truncal fat percentage, glycemic markers, lipid profiles and liver disease markers—were compared between Asian and non-Asian participants within the 85–95th percentile and ≥ 95th percentile ranges. Metabolic parameter-based matching analyses identified corresponding BMI percentiles between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Asian children had more pronounced metabolic abnormalities than non-Asians in the overweight and obesity groups. After matching for metabolic parameters, Asians had the same levels of metabolic dysfunction at lower BMI percentiles than non-Asians, with averaged differences of approximately 3–9 BMI percentiles across various BMI percentile ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Asian children and adolescents experience elevated metabolic risks at currently defined BMI percentiles. Lower BMI cutoffs targeting the 80th percentile for overweight and 90th percentile for obesity may improve early detection of metabolic risks in the Asian paediatric population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central Adiposity, Rather Than in Utero Exposure to Maternal Obesity or Gestational Diabetes, Predicts Metabolic Syndrome Risk in Children Aged 4–10 Years 中枢性肥胖,而不是子宫内暴露于母体肥胖或妊娠期糖尿病,预测4-10岁儿童代谢综合征风险
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-12-10 DOI: 10.1111/ijpo.70066
Daniel O. Mensah, Alysha B. Everett, Amelia E. Fouts, Gretchen L. Hoelscher, Samantha L. Martin, Jessica S. Bahorski, Priscilla H. Mensah, Makenzie L. Callahan, W. Timothy Garvey, Paula C. Chandler-Laney

Background

Children born to mothers with obesity or gestational diabetes mellitus (GDM) face elevated risks of central adiposity and adverse cardiometabolic outcomes, including metabolic syndrome (MetS) and systemic inflammation. However, it remains unclear whether these risks are primarily driven by current adiposity or by in utero exposure. This study investigated associations between waist circumference (WC), waist-to-height ratio (WHtR), and continuous MetS (cMetS) scores in children, and evaluated whether in utero exposure to maternal obesity or GDM moderated these relationships. Associations between cMetS and cardiometabolic biomarkers were also examined.

Methods

Children were grouped by maternal early-pregnancy weight status and GDM diagnosis: (1) normal weight without GDM, (2) overweight/obesity without GDM, and (3) overweight/obesity with GDM. WC was classified as < 85th or ≥ 85th percentile; WHtR as < 0.5 or ≥ 0.5. cMetS scores were computed with and without the WC component. Group differences and associations were assessed using ANCOVA and correlation analyses.

Results

WC and WHtR were strong predictors of cMetS, independent of in utero exposure group. Children with WC ≥ 85th percentile or WHtR ≥ 0.5 had significantly higher cMetS scores (p < 0.0001), even when WC was excluded from the cMetS calculation. cMetS was inversely correlated with adiponectin and positively correlated with leptin, the leptin-to-adiponectin ratio, HOMA-IR, CRP, and IL-6 (all p < 0.01).

Conclusions

Central adiposity—indexed by WC or WHtR—rather than in utero exposure, is the primary driver of cardiometabolic risk. Associations between cMetS and cardiometabolic biomarkers underscore insulin resistance and adipose tissue dysfunction as key mechanisms underlying MetS in children.

背景:肥胖或妊娠期糖尿病(GDM)母亲所生的孩子面临中枢性肥胖和不良心脏代谢结局(包括代谢综合征(MetS)和全身性炎症)的风险升高。然而,目前尚不清楚这些风险主要是由目前的肥胖还是由子宫内暴露引起的。本研究调查了儿童腰围(WC)、腰高比(WHtR)和连续代谢当量(cMetS)评分之间的关系,并评估子宫内暴露于母亲肥胖或GDM是否会调节这些关系。cmet与心脏代谢生物标志物之间的关联也被检查。方法:根据产妇妊娠早期体重状况和GDM诊断对儿童进行分组:(1)体重正常,无GDM;(2)超重/肥胖,无GDM;(3)超重/肥胖,伴GDM。结果:WC和WHtR是cMetS的强预测因子,独立于子宫暴露组。WC≥85百分位或WHtR≥0.5的儿童cMetS评分显著较高(p)。结论:以WC或WHtR为指标的中心性肥胖是心脏代谢风险的主要驱动因素,而不是子宫暴露。cMetS与心脏代谢生物标志物之间的关联强调了胰岛素抵抗和脂肪组织功能障碍是儿童MetS的关键机制。
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引用次数: 0
MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes 2型糖尿病青年胃垂直套管切除术后心脏脂肪、腹部脂肪和心功能的MRI分析。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-11-17 DOI: 10.1111/ijpo.70068
Tyler J. Dobbs, Linnea Gutierrez, Houchun Harry Hu, Kendall S. Hunter, Brian Fonseca, Lorna Browne, David Winter, Melanie G. Cree, Laura Pyle, Jonathan L. Hills-Dunlap, Jane E. B. Reusch, Megan M. Kelsey, Thomas H. Inge, Petter Bjornstad, Kristen J. Nadeau

Background

Adolescents with youth-onset type 2 diabetes (YO-T2D) have an increased risk for cardiometabolic complications. The impact of vertical sleeve gastrectomy (VSG) on fat distribution and cardiac morphology/function in YO-T2D is unknown.

Objectives

To evaluate changes in body composition, abdominal and cardiac fat depots, and cardiometabolic health in adolescents with YO-T2D undergoing VSG.

Methods

Anthropometrics, labs and imaging were used to assess participants pre-surgery and 3–12 months post-surgery. MRI quantified pericardial (PAT), epicardial (EAT), subcutaneous (SAT) and visceral adipose tissue (VAT), hepatic fat fraction (HFF) and cardiac morphology/function. Mixed-effects models assessed longitudinal changes.

Results

By 12 months, weight decreased from 134.3 ± 5.1 to 103.3 ± 5.2 kg, VAT 1943 ± 148 to 1248 ± 150 cm3, HFF 23.2% ± 2.3% to 5.3% ± 2.3% and PAT and EAT by 27% and 33% (all p < 0.01). Homeostatic model assessment of insulin resistance (HOMA-IR) improved (7.8 ± 1.2 to 1.7 ± 1.2 [p < 0.01]). BMI, SAT, resting heart rate (RHR), left ventricular (LV) mass and cardiac output (CO) also decreased (all p < 0.05). VAT decreases correlated with decreases in HFF (r = 0.70, p = 0.01), HOMA-IR (r = 0.60, p = 0.04) and CO (r = 0.70, p = 0.03). HFF decreases correlated with decreases in BMI (r = 0.70, p = 0.03), HOMA-IR (r = 0.90, p < 0.001), RHR (r = 0.90, p = 0.002), CO (r = 0.80, p = 0.007) and LV mass (r = 0.70, p = 0.02).

Conclusions

VSG reduces ectopic and regional fat and improves associated insulin sensitivity and cardiac health in adolescents with YO-T2D.

背景:青少年2型糖尿病(YO-T2D)发生心脏代谢并发症的风险增加。垂直袖胃切除术(VSG)对YO-T2D患者脂肪分布和心脏形态/功能的影响尚不清楚。目的:评价青少年YO-T2D患者行VSG后身体组成、腹部和心脏脂肪库以及心脏代谢健康的变化。方法:术前和术后3-12个月采用人体测量学、实验室和影像学方法对参与者进行评估。MRI量化心包(PAT)、心外膜(EAT)、皮下(SAT)和内脏脂肪组织(VAT)、肝脏脂肪分数(HFF)和心脏形态/功能。混合效应模型评估了纵向变化。结果:12个月后,青少年YO-T2D患者体重从134.3±5.1降至103.3±5.2 kg, VAT从1943±148降至1248±150 cm3, HFF从23.2%±2.3%降至5.3%±2.3%,PAT和EAT分别下降27%和33%(均为p)。结论:VSG减少异位和局部脂肪,改善相关胰岛素敏感性和心脏健康。
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引用次数: 0
Risk Factors for Development of Type 2 and Prediabetes in Children During the COVID-19 Pandemic COVID-19大流行期间儿童2型糖尿病和前驱糖尿病发展的危险因素
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-11-14 DOI: 10.1111/ijpo.70070
Jeralyn B. Jacobs, Haihong Hu, Seohyun Kim, Yi-shin Sheu, R. Clayton Bishop, Karen Chesbrough, Nancy S. Weinfield

Background

During the COVID-19 pandemic, there was a rise in the incidence of type 2 diabetes (T2D) and prediabetes in children and teenagers. We investigated whether new risk factors for diabetes in children emerged during the pandemic period.

Methods

Using health records of a large, integrated health system, we evaluated the incidence of new-onset T2D and prediabetes in patients aged 0–19 years from 2020 to 2023. We utilised descriptive statistics, chi-square and multivariable logistic regressions to predict the risk of T2D and prediabetes.

Results

Compared to children with normal weight, children with obesity (p < 0.0001) and those overweight (p < 0.0001) were more likely to develop prediabetes, and children with obesity were more likely to develop T2D (p < 0.0001). Children aged 12–19 were more likely to develop prediabetes (p < 0.0001) and T2D (p < 0.0001) compared to younger children. Publicly insured children were more likely to develop T2D (p = 0.003). Black and Asian children were at higher risk than White individuals of developing both prediabetes (p < 0.0001) and T2D (p = 0.019 and p = 0.02, respectively). COVID-19 infection was not a meaningful risk factor for prediabetes or T2D.

Conclusion

Risk factors for prediabetes and T2D in children remained the same during the pandemic as prior: adolescents, overweight/obese patients, publicly insured individuals and non-White individuals.

背景:在2019冠状病毒病大流行期间,儿童和青少年中2型糖尿病(T2D)和前驱糖尿病的发病率有所上升。我们调查了在大流行期间是否出现了儿童糖尿病的新危险因素。方法:利用大型综合卫生系统的健康记录,评估2020 - 2023年0-19岁患者新发T2D和前驱糖尿病的发病率。我们使用描述性统计、卡方和多变量logistic回归来预测T2D和前驱糖尿病的风险。结论:大流行期间儿童糖尿病前期和T2D的危险因素与之前相同:青少年、超重/肥胖患者、公共保险个体和非白人个体。
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引用次数: 0
Childhood Obesity and Age-Related Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Evidence 儿童肥胖和年龄相关疾病:孟德尔随机化证据的系统回顾和荟萃分析。
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-11-14 DOI: 10.1111/ijpo.70071
Haoxue Zhu, Xinghao Yi, Mengyu He, Siyi Wu, Ming Li, Shan Gao

Background

Childhood obesity poses a global health threat, with emerging evidence suggesting distinct adipocyte senescence patterns compared to adult-onset obesity. We systematically explored whether childhood obesity may be causally associated with age-related diseases through a meta-analysis of Mendelian randomization (MR) evidence.

Methods

We screened six databases (MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library and CNKI) and identified 45 MR articles examining paediatric adiposity and major age-related diseases. For each disease, we performed a meta-analysis using results from published MR studies and conducted de novo analyses based on genetic data from UK Biobank (n = 453 169), FinnGen (n > 200 000) and other large consortiums.

Results

The meta-analysis examined 44 diseases across 9 systems, revealing suggestive associations between genetically determined childhood obesity and increased risk of 16 age-related diseases, including hypertension, atrial fibrillation, coronary artery disease, stroke and myocardial infarction; colorectal, endometrial and pancreatic cancers; nonalcoholic fatty liver disease, type 2 diabetes, diabetic nephropathy; multiple sclerosis and gout; Alzheimer's disease; depression and asthma. Three of these associations were marginal (p = 0.03–0.05). Paradoxical inverse associations emerged for breast cancer and ulcerative colitis.

Conclusion

The findings from this meta-analysis underscore associations between childhood adiposity and multisystem age-related pathologies, underscoring the imperative for early obesity prevention.

背景:儿童肥胖是一个全球性的健康威胁,新出现的证据表明,与成人发病的肥胖相比,儿童肥胖的脂肪细胞衰老模式不同。通过对孟德尔随机化(MR)证据的荟萃分析,我们系统地探讨了儿童肥胖是否与年龄相关疾病有因果关系。方法:我们筛选了6个数据库(MEDLINE、PubMed、EMBASE、Web of Science、Cochrane Library和CNKI),筛选了45篇探讨儿童肥胖和主要年龄相关疾病的MR文章。对于每种疾病,我们使用已发表的MR研究结果进行了荟萃分析,并基于来自UK Biobank (n = 453169)、FinnGen (n = 20000)和其他大型财团的遗传数据进行了从头分析。结果:荟萃分析检查了9个系统的44种疾病,揭示了遗传决定的儿童肥胖与16种年龄相关疾病风险增加之间的暗示关联,包括高血压、心房颤动、冠状动脉疾病、中风和心肌梗死;结直肠癌、子宫内膜癌和胰腺癌;非酒精性脂肪肝、2型糖尿病、糖尿病肾病;多发性硬化症和痛风;阿尔茨海默病;抑郁症和哮喘。其中三个相关性为边缘相关性(p = 0.03-0.05)。在乳腺癌和溃疡性结肠炎中出现了矛盾的负相关。结论:这项荟萃分析的发现强调了儿童肥胖与多系统年龄相关病理之间的联系,强调了早期预防肥胖的必要性。
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引用次数: 0
The Association Between Schoolwork Pressure and Overweight/Obesity in Swedish Schoolchildren Across Different Socioeconomic Groups 瑞典不同社会经济群体学童学业压力与超重/肥胖的关系
IF 2.7 3区 医学 Q1 PEDIATRICS Pub Date : 2025-11-12 DOI: 10.1111/ijpo.70067
Cassandra Comey, Kenisha Russell Jonsson, Maria Corell

Background

In Sweden, schoolwork pressure and adolescent overweight/obesity prevalence have increased in recent decades. This study investigates the relationship between schoolwork pressure and weight status, considering the moderating role of socioeconomic background.

Methods

We analysed pooled cross-sectional data from 12 154 adolescents in the nationally representative Swedish Health Behaviour in School-aged Children surveys (2013/14, 2017/18, 2021/22). Logistic regression models examined the association between schoolwork pressure and self-reported overweight/obesity status (standardised by IOTF cut-offs) across socioeconomic backgrounds assessed by the Family Affluence Scale (FAS) and perceived family wealth (PFW). We calculated population attributable fractions to quantify schoolwork pressure's contribution to overweight/obesity.

Results

37% of students reported high schoolwork pressure, and 14% had overweight or obesity. High schoolwork pressure was associated with increased odds of overweight/obesity (OR 1.17, 95% CI 1.03–1.32). Adolescents experiencing high pressure from low socioeconomic backgrounds FAS (OR 2.10, 95% CI 1.60–2.76) or PFW (OR 1.82, 95% CI 1.22–2.71) had the highest odds of overweight/obesity. Approximately 5% of overweight/obesity cases were attributable to high schoolwork pressure.

Conclusions

High schoolwork pressure increases the likelihood of adolescent overweight/obesity, particularly for disadvantaged socioeconomic groups. Implementing policies to reduce academic stress and providing targeted support are essential for promoting healthier outcomes.

背景:在瑞典,近几十年来,学业压力和青少年超重/肥胖患病率有所增加。本研究探讨学业压力与体重状况的关系,并考虑社会经济背景的调节作用。方法:我们分析了全国代表性瑞典学龄儿童健康行为调查(2013/14、2017/18、2021/22)中12154名青少年的汇总横截面数据。逻辑回归模型检验了家庭富裕量表(FAS)和感知家庭财富(PFW)评估的社会经济背景下,学业压力与自我报告的超重/肥胖状况(由IOTF截止值标准化)之间的关系。我们计算了人口归因分数来量化学业压力对超重/肥胖的贡献。结果:37%的学生报告了高中学业压力,14%的学生超重或肥胖。高中学业压力与超重/肥胖的几率增加相关(OR 1.17, 95% CI 1.03-1.32)。来自低社会经济背景(FAS) (OR 2.10, 95% CI 1.60-2.76)或PFW (OR 1.82, 95% CI 1.22-2.71)的高压力青少年超重/肥胖的几率最高。大约5%的超重/肥胖病例可归因于高中学业压力。结论:高中学业压力增加了青少年超重/肥胖的可能性,特别是对社会经济弱势群体。实施减轻学业压力的政策和提供有针对性的支持对于促进更健康的结果至关重要。
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引用次数: 0
期刊
Pediatric Obesity
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