South African Journal of Botany最新文献

{"title":"Exploring Tephrosin: A review of its potential in cancer therapy and multifaceted anticancer mechanisms","authors":"Mohamed S. Anwer,&nbsp;Wael M. El-Sayed","doi":"10.1016/j.sajb.2024.12.014","DOIUrl":"10.1016/j.sajb.2024.12.014","url":null,"abstract":"<div><div>Cancer statistics highlight diverse susceptibilities, necessitating tailored global research and interventions. Conventional cancer treatments like chemotherapy and radiotherapy lack specificity, causing severe side effects. Novel targeted therapies exert cytostatic effects by modulating cell cycle regulators, disrupting microtubules, or inducing apoptosis. Tephrosin, a rotenoid isoflavonoid found in the family Fabaceae, exhibits promising anticancer properties against various cancer types. This review aimed to comprehensively summarize tephrosin's anticancer activity, explore its mode of action and safety profile, and address gaps in the literature regarding its pharmacokinetics and pharmacodynamics. Tephrosin exerted anticancer activities against skin, cervical, breast, ovarian, pancreatic, colorectal, lung, and leukemia. Tephrosin acts through various pathways including inhibiting NF-κB signaling, inhibiting autophagy, inducing different types of apoptosis, inhibiting elongation factor-2 kinase, reducing the phosphorylation of growth factors, blocking downstream signaling pathways such as PI3K/Akt and Ras/MAPK, p38/MAPK, and STAT3, arresting the cell cycle at the G2/M phase, inducing DNA damage and oxidative stress in cancer cells, and suppression of enzymes involved in extracellular matrix degradation and metastasis. This review revealed the lack of antioxidant, pharmacodynamics, and pharmacokinetics studies on this promising isoflavonoid. Tephrosin's multifaceted mechanisms make it a compelling candidate for further investigation in cancer therapy.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 320-328"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Tamarindus indica L. in diabetes: A systematic review of current evidence","authors":"Intan Nurashikin Mohd Adnan,&nbsp;Jaime Jacqueline Jayapalan,&nbsp;Sarni Mat Junit,&nbsp;Azlina Abdul Aziz","doi":"10.1016/j.sajb.2024.12.019","DOIUrl":"10.1016/j.sajb.2024.12.019","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a major non-communicable disease that impacts populations globally, resulting in over 6 million deaths in 2021 alone. Patients with DM often experience chronic hyperglycemia, which can lead to complications such as cardiovascular disease, neuropathy, and nephropathy. Recent research emphasizes the potential role of natural products in managing hyperglycemia and mitigating its associated complications. One notable natural product, <em>Tamarindus indica</em> L., has been scientifically shown to have hypoglycemic properties, making it a promising complementary therapy for managing diabetes.</div></div><div><h3>Scope and approach</h3><div>This systematic review aims to update the effects of <em>T. indica</em> on DM. Articles were searched from Cochrane, PubMed, Science Direct, Scopus, and Web of Science up to July 2024. Thirty-one articles comprising in vitro and in vivo studies on the hypoglycemic effects of <em>T. indica</em> were included in this review. Two reviewers performed the literature search, screening and assessment of the articles. The quality of the animal studies was evaluated using SYRCLE's risk of bias tool.</div></div><div><h3>Key findings and conclusions</h3><div>The seeds, fruits, leaves, and other aerial parts of <em>T. indica</em> showed hypoglycemic effects. The extent of these effects is influenced by factors such as the method of plant extraction, dosage, treatment duration, and the diabetic model used. Protection from oxidative stress, inhibition of pro-inflammatory cytokines, inhibition of α-amylase and α-glucosidase, and regulation of insulin secretion, as well as glucose, glycogen, and lipid metabolism, were the likely mechanisms that contributed to the hypoglycemic effects. In-depth studies on the hypoglycemic mechanisms of <em>T. indica</em> extracts especially at the molecular level could increase our understanding of its therapeutic use and ensure safety for patient use.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 542-554"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colocasia esculenta (L.) Schott (Araceae; taro): global invasion history and prognosis for South Africa","authors":"Emily J. McCulloch-Jones ,&nbsp;Bokamoso K. Lemme ,&nbsp;Laura Fernandez Winzer ,&nbsp;David M. Richardson ,&nbsp;John R.U. Wilson","doi":"10.1016/j.sajb.2024.11.037","DOIUrl":"10.1016/j.sajb.2024.11.037","url":null,"abstract":"<div><div><em>Colocasia esculenta</em> (taro), native to tropical Southeast Asia, is an emergent aquatic plant with a wide global distribution. Valued for its agricultural, horticultural, medicinal, and cultural uses, it also has become invasive in some places, spreading unaided along slow-flowing water courses through corm division. <em>Colocasia esculenta</em> was introduced to South Africa at least a century ago (∼ 1918), but widespread invasions are recent, raising concerns that the species could become a harmful invader in the country. This study reviews the history of introduction, invasions, and impacts of <em>C. esculenta</em> around the world; maps its current and potential distribution in South Africa; and, based on a risk analysis, develops recommendations for its management and regulation. <em>Colocasia esculenta</em> has been introduced to at least 180 territories (countries or island states), with records of invasion from 21 of these (9 island and 12 mainland territories). The negative environmental impacts were scored as ‘Moderate’ with the formation of dense mats leading to declines in local native populations; and socioeconomic impacts scored as ‘Minor’ as it has irritant properties if not properly handled and prepared. In South Africa, <em>C. esculenta</em> is found in six provinces but most extensively in the Western Cape and KwaZulu-Natal. Based on a species distribution model, <em>C. esculenta</em> could substantially expand its range in areas where it is already established. <em>Colocasia esculenta</em> was classified as ‘high risk’ for South Africa, with high socio-economic benefits, and as such is identified as a potential conflict generating species. We recommend it is regulated as category 2 (permits are required to carry out any restricted activity) under the South African regulations and suggest exemptions on subsistence farming but prohibitions on all farming in riparian zones. Further investigation is needed for potential management options, including biological control. Recommendations should be reviewed after determining whether some of the subspecific entities present in the country pose a low risk, as then further exemptions or prohibitions might be appropriate.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 665-673"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do structural and functional traits modulation determine the ecological fate of castor bean (Ricinus communis L.) under variable pedospheric and atmospheric conditions?","authors":"Ummar Iqbal,&nbsp;Muhammad Faisal Gul,&nbsp;Muhammad Usama Aslam,&nbsp;Fahad Ur Rehman,&nbsp;Umar Farooq","doi":"10.1016/j.sajb.2024.11.029","DOIUrl":"10.1016/j.sajb.2024.11.029","url":null,"abstract":"<div><div><em>Ricinus communis</em> (Euphorbiaceae) is a highly valuable industrial crop, providing essential materials such as rubber, oil, and seed cake, which are used in textiles, plastics, varnishes, and electrical insulation. Beyond its economic importance, understanding the structural and functional adaptations of <em>R. communis</em> in its natural environment is crucial for comprehending its ecological dynamics and broader environmental impact. This research not only links its industrial significance to its ecological role but also contributes to its sustainable cultivation and management. To gain deeper insights into these adaptations, a study was conducted on fifteen natural populations of <em>R. communis</em>, collected from diverse and challenging habitats (i.e., open barren fields, agricultural lands, water channels and roadsides) in Punjab, Pakistan. The aim of this study is to uncover how <em>R. communis</em> adapts to a wide range of climatic and soil conditions, providing a comprehensive understanding of its resilience strategies. Results showed that open and barren land populations exhibited superior above-ground growth and biomass accumulation, along with remarkable physiological adaptations, including elevated levels of beneficial ions, osmolytes (soluble proteins, proline, and glycine betaine), and antioxidants (superoxide dismutase, catalase, and peroxidase). Additionally, these populations displayed anatomical characteristics such as an enlarged root cellular area, intensive sclerification, a thicker endodermis in roots, thicker collenchyma and epidermal layers, larger cortical and phloem regions in the stems, and thicker leaves with larger stomata. Agricultural field populations displayed elevated levels of photosynthetic pigments and improved root structures, with wider metaxylem vessels that enhance water and nutrient uptake. Populations growing along water channels exhibited significant adaptations, such as larger leaves, increased below-ground biomass, and enlarged cortical cells and vascular bundles in all organs. It is concluded that <em>R. communis</em> has evolved adaptive mechanisms at both the structural and functional levels to ensure survival under diverse climatic and pedospheric conditions. Understanding the specific adaptations and mechanisms employed by <em>R. communis</em> under different stresses is crucial for crop management and the development of breeding programs aimed at enhancing its resilience and productivity.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 68-87"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular core responses to multiple abiotic stresses in barley (Hordeum vulgare L.): Insights from global transcriptome analysis","authors":"Bahman Panahi","doi":"10.1016/j.sajb.2024.11.039","DOIUrl":"10.1016/j.sajb.2024.11.039","url":null,"abstract":"<div><div>Environmental stresses significantly affect crop yields and threaten global food security, underscoring the need for developing stress-tolerant crop varieties. This study addresses the gap in understanding stress-responsive mechanisms by analyzing 372 RNA-seq profiles from 14 barley studies on various abiotic stresses. Data quality was assessed and trimmed reads were aligned to the MorexV3 genome and quantified with HT-seq. Differential gene expression was determined, after batch effects correction. Core differentially expressed genes (DEGs) were identified through Fisher's method p-value combination method. Then, identified core genes were subjected to functional enrichment analysis via GO, KEGG, and PPI networks. Furthermore, Hub genes of constructed network were detected based on topological algorithms. Validation of core DEGs were further performed through χ2 goodness of fit test. Meta analysis identified the 360 core DEGs response to multiple abiotic stress. Functional enrichment analysis showed that these genes mostly enrich in phytohormones, calcium signaling, and secondary metabolism, starch and sucrose metabolism, and glutathione metabolism. Results of this study also showed that the upregulation of glucose-6-phosphate isomerase and sucrose synthase 4 underscores their importance in maintaining energy and osmotic balance of barley during multiple abiotic stress condition. Moreover, our survey showed that the ABC cation transporters, especially ABCC4 and ABCD1 are crucial for ion homeostasis of barley during multiple abiotic stress condition. Finally, network analysis of the identified core-DEGs highlighted the functional importance of SUS4 (Sucrose synthase 4), HSP70-4 (Heat shock protein 70 kDa 4), GLN2 (Glutamine synthetase), GAPC2 (Glyceraldehyde-3-phosphate dehydrogenase), ALDH7B4 (Aldehyde dehydrogenase family 7 member B4), and APX3 (L-ascorbate peroxidase 3) under multiple abiotic stress. Overall, this study provides a comprehensive understanding of the molecular responses to abiotic stress in barley and highlights key pathways and genes that contribute to stress adaptation and resilience.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 237-250"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fire ecology and management in South Africa: A history of research achievements and future challenges","authors":"Brian W. van Wilgen","doi":"10.1016/j.sajb.2025.01.004","DOIUrl":"10.1016/j.sajb.2025.01.004","url":null,"abstract":"&lt;div&gt;&lt;div&gt;This paper provides a review of the history of fire research over the past century, the current understanding fire ecology and management, and gaps in knowledge in South Africa. Fire regimes (i.e. the combination of frequency, season and intensity of fire) have been quantified for the main fire-prone vegetation types (fynbos, grassland and savanna) in the eastern and southern parts of the country. Early ecologists regarded fires as harmful, but a growing realization that fires were inevitable and potentially necessary led to the establishment of long-term experiments in fynbos and montane grassland (by the Department of Forestry) and savannas (in the Kruger National Park) in the 1940s and 1950s. Formal collaborative research programs were initiated in the 1970s, including the CSIR's National Programme for Ecosystem Research and the Scientific Committee on Problems of the Environment's (SCOPE) project to synthesize knowledge on the ecological effects of fire. These and other initiatives improved understanding substantially. It is now known that fynbos vegetation is dependent of fires at intervals of 10 – 20 years in the dry summer season, while grasslands are resilient under shorter fire return periods (2 – 3 years) in the dry winter. Savanna fire ecology tends to be more complex as multiple factors (rainfall, soil fertility, herbivory and fire that vary over space and time) interact to determine the relative proportions of grass and trees. Forest vegetation is not fire-prone, but fire strongly influences the distribution of forests in the landscape. Managers of protected areas, rangelands and water catchments use fire to achieve ecological goals, including maximizing rangeland productivity, reversing woody encroachment, reducing tree mortality, and controlling invasive alien species or disease vectors (mainly ticks). Some ecological goals aim to achieve “natural” or heterogenous fire patterns, assuming that these will conserve biodiversity. Social goals include the prevention of destructive wildfires and protection of infrastructure, the reduction of greenhouse gas emissions, and the protection of harvestable resources. Management has in some cases been adaptive, and targets have been altered as understanding grew, and as practical experience coupled with periodic reflection helped to set more realistic goals. Research findings have altered approaches to management in several instances or confirmed that current practices were appropriate. There are however limits to what management can practically achieve. Spatial heterogeneity and seasonal distribution of fires are more easily manipulated at a landscape scale than fire return intervals, especially in more arid areas. Several challenges remain. Climate change may increase the incidence of high fire danger weather, although these projections are more severe for the fire-free parts of the country. Effective implementation of prescribed burning programs necessitates trade-offs between safe","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 699-712"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new species of Ruschieae from north-western South Africa and south-western Namibia","authors":"Cornelia Klak ,&nbsp;Pieter C. Van Wyk ,&nbsp;Pavel Hanáček ,&nbsp;Peter V. Bruyns","doi":"10.1016/j.sajb.2024.12.013","DOIUrl":"10.1016/j.sajb.2024.12.013","url":null,"abstract":"<div><div>Here we describe two new species of the Ruschieae from the arid Gariep region of north-western South Africa and south-western Namibia. <em>Ruschia gariepensis</em> Klak &amp; P.C. van Wyk forms large spreading, floriferous shrubs and is easily distinguished from similar-looking species in <em>Ruschia</em> subg. <em>Tumidulae</em> (Haw.) Dehn by its 5- to 7-locular fruits on the same plant. <em>Mitrophyllum minutum</em> Klak &amp; P.C. van Wyk, from the Richtersveld of South Africa belongs to <em>Mitrophyllum</em> subg. <em>Mitrophyllum</em> and differs from all other <em>Mitrophyllum</em> by its dwarf habit and small flowers.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 392-396"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and anti-breast cancer activities, GC–MS profiling, molecular docking and pharmacokinetic studies of nutritious white kidney beans","authors":"Pallavi B Jadhav,&nbsp;Hemlata J Bhosale,&nbsp;Shailesh V Mamdapure,&nbsp;Sunil B Jadhav","doi":"10.1016/j.sajb.2024.11.033","DOIUrl":"10.1016/j.sajb.2024.11.033","url":null,"abstract":"<div><div>White kidney beans (<em>Phaseolus vulgaris</em> L.), a type of common bean, are very noteworthy due to their distinct biological activity and great nutritional value. This study aimed to assess the effectiveness of bean extracts in eliminating bacterial uropathogens, finding the active components of beans, and the potential of their chloroform extract to combat the protein Er-α found in breast cancer cells. Bean extracts with acetone, chloroform, and ethyl acetate showed higher antibacterial action than other extracts against <em>Pseudomonas aeruginosa</em> (MIC, 64 µg/ml), while methanol and acetone extracts were more effective against <em>Klebsiella pneumoniae</em> (MIC, 8 µg/ml), and methanol extract was more inhibitory to <em>Escherichia coli</em> (MIC, 16 µg/ml). The chloroform extract was found to be cytotoxic in MCF-7 cells, with a CC₅₀ value of 3.849 µg/ml based on the MTT experiment. The GC–MS analysis of chloroform extract revealed 17 compounds, with lupeol, 8-pentadecanol, and 2-butoxyethyl oleate being key elements. Molecular docking investigations show that lupeol has a binding affinity of −10.5 Kcal/mol and a stronger interaction with Er-α than 8-pentadecanol and 2-butoxyethyl oleate. The <em>in silico</em> pharmacokinetic and toxicological properties of chosen substances were evaluated using Swiss ADME and admetSAR, and lupeol was found to be satisfactory. Lupeol exhibited a higher Pa score (0.799) for breast cancer prevention than doxorubicin, 2-butoxyethyl oleate, or 8-pentadecanol. The current study indicated the antibacterial importance of methanol and chloroform extracts of <em>P. vulgaris</em> seeds as well as the importance of lupeol from chloroform extract as a potential treatment for breast cancer.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 225-236"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex situ conservation of Elaeocarpus angustifolius Blume via in vitro regeneration using DKW medium","authors":"S Leo Arockia Raj,&nbsp;P Charles,&nbsp;S Dennis,&nbsp;Antoine Lebel,&nbsp;Ravindhran. R","doi":"10.1016/j.sajb.2024.12.021","DOIUrl":"10.1016/j.sajb.2024.12.021","url":null,"abstract":"<div><div>An accurate concentration of growth hormones in the medium is essential for successful tissue culture experiments in tree species. This study evaluated the efficacy of various plant growth regulators (PGRs) in Driver-Kuniyaki-Walnut (DKW) medium for callus induction and <em>Elaeocarpus angustifolius</em> Blume plant regeneration. Leaves from three-year-old sapling were inoculated onto DKW medium supplemented with 2-4D, NAA and Kin (0.5 mg L^-1 – 4 mg L^-1) for callus initiation. The optimal concentration for initiating callus was found to be 2 mg L^-1 of 2, 4-D. The DKW medium supplemented with 2 mg L^-1 Kinetin (Kin) showed the highest shoot regeneration frequency (91%) and an average of 21.2±1.93 shoots per explant and shoot length of 3.8±0.92cm. For rooting, a 1/2-strength DKW medium supplemented with indole-3-butyric acid (IBA) (2.5 mg L^-1) had maximum rooting frequency (83%) with an average of 3.2<span><math><mo>±</mo></math></span>0.42 cm roots per explant and root length of 2.82<span><math><mo>±</mo></math></span>1.02cm. A survival rate of 98% was achieved once <em>in vitro</em> regenerated plantlets were acclimated to field conditions. Three markers such as RAPD, ISSR, and SSR were used to confirm the genetic fidelity of the plantlets. The <em>in vitro</em>-raised clones were found to be true-to-type as all bands from the <em>in vitro</em> regenerated plants were monomorphic and identical to those of the <em>in vivo</em> plants.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 510-516"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical marvels: Solanum nigrum's journey from plant to diabetes treatment","authors":"Priyanka Paul ,&nbsp;Raj Kamal ,&nbsp;Aman Rai ,&nbsp;Ankit Awasthi ,&nbsp;Rohit Bhatia","doi":"10.1016/j.sajb.2024.12.026","DOIUrl":"10.1016/j.sajb.2024.12.026","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a complex metabolic disorder characterized by high blood sugar levels. It can be potentially managed by several medicinal plants. Extracts of <em>S. nigrum</em> have demonstrated various beneficial properties, including anti-inflammatory, antioxidant, antihyperlipidemic, and liver-protective effects, and have improved glycemic control. This review discusses the therapeutic potential of <em>S. nigrum</em> for diabetes and various targeted signaling pathways of <em>S. nigrum</em> as well as biosynthesis of two phytoconstituents. Additionally, it also covers the various isolation and extraction methods and different analytical methods for the identification of isolated compounds. Furthermore, various studies reported so far for the management of DM are also discussed along with the different nanoformulations of <em>S. nigrum</em>.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"177 ","pages":"Pages 561-571"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}