South African Journal of Botany最新文献

{"title":"Protocorm-like bodies (PLBs) in monocotyledonous plants: A comprehensive review of a specialized pathway for plant propagation","authors":"Sadaruddin Chachar,&nbsp;Nazir Ahmed,&nbsp;Xiu Hu","doi":"10.1016/j.sajb.2025.04.027","DOIUrl":"10.1016/j.sajb.2025.04.027","url":null,"abstract":"<div><div>Protocorm-Like Bodies (PLBs) have emerged as promising tools for the regeneration of monocotyledonous plants, offering valuable applications in agriculture, horticulture, and conservation. Mimicking early plant embryo development, PLBs provide an efficient method for clonal propagation, enabling the large-scale production of monocots, including economically important crops and endangered species. This review examines the key methodologies for PLB induction, emphasizing the importance of explant selection, culture medium composition, and environmental factors. It explores the potential of PLBs in plant breeding, genetic engineering, and conservation of genetic diversity, highlighting their ability to produce genetically uniform plants for ex situ conservation efforts. Despite these advantages, challenges, such as somaclonal variation and genotype-dependent responses, limit broader commercial applications. This review discusses strategies to mitigate these issues, including optimizing growth regulators and utilizing molecular markers for early detection of genetic variation. Despite the promising advantages of PLBs, this review identifies the need for further research to overcome existing challenges, particularly in minimizing genetic variability and optimizing protocols for diverse monocot species. This review also identifies the need for continuous research on the molecular and epigenetic mechanisms underlying PLB development to refine tissue culture techniques, minimize variability, and improve regeneration efficiency. Integrating PLB propagation with cutting-edge biotechnological advancements promises to advance plant science and support sustainable agriculture and the preservation of global biodiversity.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 141-161"},"PeriodicalIF":2.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethno pharmacological evidence and exploration of the phytochemical profile by GC-MS of bioactive compounds extracted from Sterculia setigera","authors":"Dramane Paré ,&nbsp;Jotham Yhi-pênê N'do ,&nbsp;Nikodème Vonogo Kabré ,&nbsp;Mahamadi Nikiema ,&nbsp;Emmanuel Zongo ,&nbsp;Roland Nâg-Tiero Méda ,&nbsp;Adama Hilou","doi":"10.1016/j.sajb.2025.03.039","DOIUrl":"10.1016/j.sajb.2025.03.039","url":null,"abstract":"<div><div><em>Sterculia setigera</em> is a plant used in traditional medicine to fight respiratory diseases. In phytotherapeutic care, optimization of bioactive compound extraction is a necessity for greater efficacy. This study aimed to determine an optimal procedure for obtaining bioactive compounds through fractionation of the extracts, with tests to assess their anti-microbial and anti-oxidant potential. Extraction factors included solvent systems (distilled water, ethanol, hexane, dichloromethane, ethyl acetate) and methods (decoction, maceration). The two most active extracts, after evaluation of antioxidant activity and antimicrobial activity, were then subjected to gas chromatography-mass spectrometry (GC-MS) analysis to obtain a phytochemical profile. Extraction by ethanolic maceration gave the highest yield of polyphenol compounds (97.20± 0.26 mg gallic acid equivalent per gram extract). Also for the antioxidant test, ethanolic macerate showed the best activity across the three methods used. The ethanolic extract and ethyl acetate fraction showed a strong inhibitory effect against bacteria with better activity coefficients obtained on <em>Micrococcus luteus</em> (0.188 cm²/µl and 0.132 cm²/µl). The GC-MS phytochemical profile revealed the presence of biomolecules, the main ones of which are Junipene, propylformic acid, n-hexadecanoic acid and 1-octyne. These results demonstrate the richness of <em>S. setigera</em> trunk bark in bioactive compounds.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 117-133"},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional uses and pharmacological activities of Tetracera alnifolia wild","authors":"A.K. Camara ,&nbsp;E.S. Baldé ,&nbsp;M.S.T. Diallo ,&nbsp;M.K. Camara ,&nbsp;T.V. Bah ,&nbsp;M. Condé ,&nbsp;A. Soumah ,&nbsp;K. Kamano ,&nbsp;I. Tietjen ,&nbsp;A.M. Baldé","doi":"10.1016/j.sajb.2025.04.014","DOIUrl":"10.1016/j.sajb.2025.04.014","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div>Tetracera alnifolia Wild, is well used in traditional Guinean medicine for the treatment of infectious skin diseases. The present aim was to contribute to the valorization of Tetracera alnifolia leaves, focused on ethnomedical, biological and phytochemical investigations.</div></div><div><h3>Materials and methods</h3><div>We conducted an ethnomedical survey across several markets of the city of Conakry to identify 39 healers. Chloroform, methanol, dichloromethane, and aqueous extracts were tested for activities against protozoa, bacteria, fungi, HIV, and SARS-CoV-2.</div></div><div><h3>Results</h3><div>The traditional healers indicated that T. alnifolia is used in the treatment of &gt;15 pathologies including Fassa (marasmus/malnutrition), Soukhou kouyé (white discharge in women), and Tèmou bankhi (sexual weakness in men). Leaves were the most used part. The modes of preparation included decoction and powder. Data from biological activities identicatied good activities of the methanolic extract against Leishmania infantum (MIC = 8.11 μg / ml) and a moderate activity on Trypanosoma brucei (MIC = 28.15 μg / ml) and Staphylococcus aureus (MIC = 29.91 μg / ml), while dichloromethane extracts acted on live SARS-CoV-2 replication with up to 53.4 % inhibition at 50 μg/mL.</div></div><div><h3>Conclusion</h3><div>These results explain at least in part the traditional use of T. alnifolia.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 134-140"},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropharmacological mechanisms and psychotherapeutic effects of essential oils: A systematic review","authors":"Gopalsamy Rajiv Gandhi ,&nbsp;Govindasamy Hariharan ,&nbsp;Singamoorthy Amalraj ,&nbsp;Varghese Edwin Hillary ,&nbsp;Hannah Caroline Santos Araujo ,&nbsp;Monalisa Martins Montalvão ,&nbsp;Lysandro Pinto Borges ,&nbsp;Ricardo Queiroz Gurgel","doi":"10.1016/j.sajb.2025.04.013","DOIUrl":"10.1016/j.sajb.2025.04.013","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Anxiety is characterized by excessive worry, fear, or uneasiness which can interfere with daily activities and relationships. Neurotransmitters like gamma-aminobutyric acid (GABA), serotonin, and dopamine affect mood, neurological functions, behaviour, cognition, and overall mental health. Imbalances in these neurotransmitters are linked to mental health disorders like depression and anxiety. In recent years, there has been an increase in the use of essential oils (EOs) in the management of the symptoms associated with anxiety and depression due to their perceived therapeutic advantages. This systematic review aimed to examine the psychotherapeutic effects and neuropharmacological mechanisms of EOs and their chemical constituents in animal studies related to various mental health conditions. A search of the literature was undertaken using the online databases PubMed, Embase, Scopus, and Web of Science, focusing on articles published until December 2023. The keywords used included \"psychotherapeutic,\" \"animal model,\" \"neuropharmacology,\" \"essential oil,\" \"plant species,\" \"anxiety,\" and \"depression\". Manual searches were also conducted online and in Google Scholar. A total of 31 research studies that met the objectives of the study were found. The results of the studies showed that EOs demonstrated significant psychotherapeutic benefits, such as anxiolytic and antidepressant effects, in animal models, mediated by modulating neurotransmitters and signalling pathways linked to mood, emotion, and anxiety regulation. Studies examined the effects of EOs extracted from plants, including &lt;em&gt;Lavandula angustifolia&lt;/em&gt; Moench (Lamiaceae), &lt;em&gt;Citrus aurantium&lt;/em&gt; L. (Rutaceae), &lt;em&gt;Curcuma caesia&lt;/em&gt; Roxb. (Zingiberaceae); &lt;em&gt;Melissa officinalis&lt;/em&gt; L. (Lamiaceae); &lt;em&gt;Piper nigrum&lt;/em&gt; L. (Piperaceae), &lt;em&gt;Citrus reticulata&lt;/em&gt; Blanco. (Rutaceae); &lt;em&gt;Curcuma caesia&lt;/em&gt; Roxb. (Zingiberaceae); &lt;em&gt;Cymbopogon citratus&lt;/em&gt; (DC.) Stapf (Poaceae), &lt;em&gt;Cinnamomum cassia&lt;/em&gt; Presl. (Lauraceae), &lt;em&gt;Melissa officinalis&lt;/em&gt; L. (Lamiaceae); &lt;em&gt;Eugenia caryophyllata&lt;/em&gt; Thunb. (Myrtaceae) and &lt;em&gt;Citrus bergamia&lt;/em&gt; L. (Rutaceae), which are considered as food flavouring plants. EOs predominantly modulate pro-inflammatory cytokines such as interleukin (IL)-6, IL-1β, tumor necrosis factor alpha (TNF-α), and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signalling pathways to regulate anxiety and depressive symptoms. They possess anti-inflammatory and antioxidant properties, reducing the inflammation and oxidative stress associated with anxiety and depression, while also increasing GABA signalling gene expression. This systematic review found that animal studies provide evidence for the psychotherapeutic effects of EOs, suggesting their potential as a safer alternative to conventional medications for anxiety and depression. However, further research is needed to validate these findings and determine optimal dosage and administration","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 90-104"},"PeriodicalIF":2.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the biophysical and molecular mechanisms underlying enhanced growth in Brassica juncea L. under lead-induced hormesis","authors":"Shalini Dhiman ,&nbsp;Ram Naresh ,&nbsp;Rajesh Kumar Singh ,&nbsp;Shiv Shanker Pandey ,&nbsp;Renu Bhardwaj ,&nbsp;Abdulaziz Abdullah Alsahli ,&nbsp;Parvaiz Ahmad","doi":"10.1016/j.sajb.2025.04.007","DOIUrl":"10.1016/j.sajb.2025.04.007","url":null,"abstract":"<div><div>Constant mining, industrial production of Lead (Pb)-based herbicides, pesticides, and batteries contributed to elevated levels of Pb in the soil. The adverse effects of high Pb doses on plants are extensively documented, however, research demonstrating any beneficial effects of low to moderate Pb levels on plants is limited, even though these effects probability are common in nature. This present study aims to examine the hormetic effects of Pb doses causing eustress enhancement in morphological, physiological, biochemical, and molecular parameters of 10 days old <em>Brassica juncea</em> L. seedlings. Our finding revealed that hormetic 18 µM and 36 µM Pb²⁺ doses, significantly increased germination percentage, root-shoot length, and fresh-dry weight of seedlings. Similar hormetic doses result in a significant increase in photosynthetic pigments, antioxidants, and chlorophyll fluorescence parameters while decreasing the pheophytin, reactive oxygen species (ROS), and malondialdehyde (MDA) content in seedlings. These hormetic Pb doses treated seedlings also enhanced maximum gene expression of growth and photosynthesis-related genes such as Chlorophyll synthase (<em>Chls</em>), Plastid terminal oxidase (<em>PTOX</em>), Photosystem II protein D1 (<em>psbA</em>), Phytoene Synthase (<em>PSY</em>), Violaxanthin de-epoxidase (<em>VD</em>), Chalcone synthase (<em>CHL</em>), and Phenylalanine ammonia-lyase (<em>PAL</em>). Also, these hormetic Pb²⁺ doses regulate the expression of genes involved in reducing oxidative stress such as Respiratory burst oxidase homolog (<em>RBOH</em>), Chlorophyllase 1 (<em>Chlase</em>), Ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit (<em>rbcs</em>), Mitogen-activated protein kinases 2, 4, and 6 (<em>MAPK2, MAPK4, MAPK6</em>). The hormetic response of seedlings to Pb²⁺ suggests a potential adaptive underlying mechanism that could increase plant growth and yield in Pb-contaminated environments. This research improves our understanding of plant-metal interactions, provides insights into changes in plant biophysiology under mild Pb-contaminated soils and strategies for crop enhancement programs.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 105-116"},"PeriodicalIF":2.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic characterization and expression analysis of the cysteine-rich Polycomb-like Protein gene family of Populus trichocarpa","authors":"Raphael Dzinyela ,&nbsp;Teja Manda ,&nbsp;Delight Hwarari ,&nbsp;Liming Yang ,&nbsp;Ali Movahedi","doi":"10.1016/j.sajb.2025.04.002","DOIUrl":"10.1016/j.sajb.2025.04.002","url":null,"abstract":"<div><div>The <em>Cysteine-rich Polycomb-like Protein (CPP)</em> gene family has emerged as a significant regulator, playing crucial roles in elucidating molecular pathways that mitigate the deleterious effects of abiotic and biotic stresses. Notwithstanding its importance, comprehensive studies focusing on the <em>CPP</em> gene family in <em>P. trichocarpa</em>, particularly under different abiotic stress responses, remain largely unexplored. In this study, the 29 <em>CPP</em> genes were identified and characterized during a genomic screening of <em>P. trichocarpa</em>. We systematically analyzed the features of their sequences, their chromosomal locations, and the 3D structures of their encoded proteins. Gene ontology and promoter region analyses revealed that the <em>CPP</em> gene family are involved in plant growth and development, phytohormone, and stress responses in <em>P. trichocarpa</em>. The interspecies evolutionary relationships, phylogenetic and protein interaction network analyses suggested that the functions of <em>PtCPP</em> genes are evolutionarily conserved in <em>A. thaliana</em>, L. <em>chinese, O. sativa</em>, and <em>P. trichocarpa</em>. Also, the expression patterns indicated that the <em>PtCPP</em> genes regulate salt, heat, cold, drought and ozone stress responses in <em>P. trichocarpa</em>. Thus, our findings will improve the understanding of the molecular mechanisms associated with stress responses in <em>P. trichocarpa</em> and provide valuable insights into the potential applications of <em>CPP</em> genes in enhancing stress resilience and sustainability in forestry and agriculture.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 67-82"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Arctium lappa organic extracts: green synthesis of silver nanoparticles and antioxidant activity","authors":"Cindy Vanessa Restrepo Burgos ,&nbsp;Sofia Mendoza ,&nbsp;Eunice Ríos Vásquez ,&nbsp;Cristian C. Villa","doi":"10.1016/j.sajb.2025.03.067","DOIUrl":"10.1016/j.sajb.2025.03.067","url":null,"abstract":"<div><div>This study investigates the phytochemical composition and antioxidant potential of <em>Arctium lappa</em> organic extracts, as well as their application in the green synthesis of silver nanoparticles (AgNPs). <em>Arctium lappa</em> leaves and flowers were extracted using various solvents, with methanol yielding the highest phenolic content, confirmed through FTIR and UV-vis analysis. The flower extracts demonstrated significant antioxidant activity, as shown by their higher inhibition in the DPPH assay compared to the methanolic leaf extract. Additionally, the extracts were used in the green synthesis of AgNPs, with solvent selection influencing the size and characteristics of the nanoparticles. This study highlights the potential of Arctium lappa as a source of bioactive compounds for both antioxidant applications and sustainable nanomaterial production. Furthermore, the combined application of UV-vis, dynamic light scattering (DLS) analysis and the analytical model highlights the significant influence of both solvent selection on the resultant size of the synthesized AgNPs.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 83-89"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants from the Annonaceous family acting on the Central Nervous System: A comprehensive review to identify potential species","authors":"R.L.S.A. Luz,&nbsp;Alexsandro Branco,&nbsp;M.B. Botura","doi":"10.1016/j.sajb.2025.03.057","DOIUrl":"10.1016/j.sajb.2025.03.057","url":null,"abstract":"<div><div>Neurological diseases are a challenge to public health due to their lethal and disabling capacity. This group of illnesses includes stroke, epilepsy, dementia and various neurodegenerative diseases. The review focuses on plants from the Annonaceous family and their respective phytocompounds with activities on the Central Nervous System (CNS). The methodology applied in this study was to carry out a detailed literature review using the following web-based databases: Google Scholar, PubMed and Science Direct. Findings revealed 118 researches correlating the Annonaceous plants with action on CNS. Studies were found with more than ten genera of the Annonaceous family. In studies, neurotoxic activities were related to acetogenins, especially anonacin, and alkaloids. Anticonvulsant, anesthetic and anticholinesterase activities have also been described in different species and with compounds extracted from different parts of plants (root, fruit, leaf, stem). Knowledge of these activities adds to the exploration of the pharmacological potential of this family.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"180 ","pages":"Pages 870-893"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mechanisms by which oleanic and maslinic acids from Cola lateritia K. Schum (Sterculiaceae) twigs inhibit prostate cancer cell growth","authors":"Michael Hermann Kengne Kamdem ,&nbsp;Timothy Grein ,&nbsp;Kevine Kamga Silihe ,&nbsp;Sebastian Maxeiner ,&nbsp;Jochen Rutz ,&nbsp;Edwin Mpho Mmutlane ,&nbsp;Dieudonné Njamen ,&nbsp;Derek Tantoh Ndinteh ,&nbsp;Stéphane Zingue ,&nbsp;Roman A Blaheta","doi":"10.1016/j.sajb.2025.03.064","DOIUrl":"10.1016/j.sajb.2025.03.064","url":null,"abstract":"<div><div>Prostate cancer (PC) therapy is fraught with various limitations, underscoring the urgency for new therapeutic approaches. <em>Cola lateritia</em> K. Schum is a medicinal plant traditionally used against prostate ailments. This finding aimed to assess <em>Cola lateritia</em> isolates’ cytotoxic potential and investigate their potential underlying mechanisms. Through column chromatography, the <em>C. lateritia</em> twigs dichloromethane-methanol extract of was fractionated, yielding eleven known compounds. The later were subsequently tested in cell growth, cell proliferation and/or cell migration/invasion. Among these, compounds (<strong>3</strong>) and (<strong>4</strong>) exhibited substantial, concentration-driven inhibition of cell growth [DU145 (CC₅₀ of 25 and 22 µg/ml), PC3 (CC₅₀ of 22 and 21 µg/ml), and LNCaP (CC₅₀ of 17 and 18 µg/ml), respectively], cell proliferation (DU145 cells), and the formation of cell clones (DU145 cells). These compounds also induced an increased proportion of apoptotic cells at 2.5 and 10 µg/ml in DU145 (∼25%) and LNCaP (∼35%) cells, as well as an increment in the G0/G1 phase arrested cells versus control. Both compounds (<strong>3</strong>) and (<strong>4</strong>) demonstrated an anti-migratory effect, decreased collagen and fibronectin cell adhesion. Compound (<strong>3</strong>) down-regulated proteins such as cdk1, cdk2, pcdk2, cyclin A, Bcl-2, and vimentin, while concurrently up-regulating p19, p27, p53, Bax, caspase-3, and E-cad proteins. Additionally, it elevated β-1 and β-4 integrins at 2.5 and 10 µg/ml concentrations. The anticancer potential of <em>Cola lateritia</em> is attributed to oleanic acid (<strong>3</strong>) and maslinic acid (<strong>4</strong>), which exhibit the potential to impede cell growth by initiating the intrinsic apoptosis pathway and exert an anti-migratory impact.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 52-66"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization and cytotoxicity effects of Hyptis suaveolens collected in Nigeria","authors":"Olatunji G. Azeez ,&nbsp;Taofik A. Adedosu ,&nbsp;Ahmed A. Hussein ,&nbsp;Akeem Arinkoola ,&nbsp;Jelili A. Badmus ,&nbsp;Idowu J. Sagbo ,&nbsp;Keenau Pearce ,&nbsp;Mongi Benjeddou ,&nbsp;Masande Yalo ,&nbsp;Masixole Makhaba","doi":"10.1016/j.sajb.2025.04.010","DOIUrl":"10.1016/j.sajb.2025.04.010","url":null,"abstract":"<div><div><em>Hyptis suaveleons</em> (L.) Poit. belongs to the <em>Laminaceae</em> family. This weed, native to tropical America, has become widespread in tropical regions worldwide. In folk medicine, plant extracts are used in the treatment of wounds, peptic ulcers, respiratory tract infections, and skin diseases among others. Thus, the importance of assessing the toxicity of plants for any human use cannot be overstated. This study analyzed the phytochemical properties of the Nigerian <em>H. suaveleons</em> population and assessed its cytotoxicity. Six bioactive compounds were isolated from the acetone extract of the <em>H. suaveolens</em> plant using silica gel column chromatography, one of which is new from natural sources. The isolated compounds were identified as 14-<em>O</em>-acetyl suaveolol (<strong>C1</strong>), suaveolol (<strong>C2</strong>), suaveolic acid (<strong>C3</strong>), dehydroabietinol (<strong>C4</strong>), maniladiol (<strong>C5</strong>), and β-sitosterol (<strong>C6</strong>) based on 1D and 2D NMR spectroscopic data. The MTT assay was used to assess the cytotoxicity effects of these metabolites on HepG2, KMST-6, and HaCaT cells. Among them, <strong>C1</strong> significantly reduced HepG2, KMST-6, and HaCaT cell viability with IC₅₀ values of 35.97, 43.48, and 65.10 µg/ml, respectively. The study suggests <strong>C1</strong> has promising anticancer properties, possibly due to the acetyl group on C-14, while <strong>C2</strong>, suaveolol, lacks this group, and did not yield any inhibitory activities. However, further research is needed to understand its mechanisms.</div></div>","PeriodicalId":21919,"journal":{"name":"South African Journal of Botany","volume":"181 ","pages":"Pages 47-51"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}